PTK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.24177829
2central nervous system myelination (GO:0022010)4.24177829
3layer formation in cerebral cortex (GO:0021819)3.70289491
4apical protein localization (GO:0045176)3.56070225
5synapsis (GO:0007129)3.53677266
6paraxial mesoderm development (GO:0048339)3.49601414
7myelination (GO:0042552)3.35278811
8ensheathment of neurons (GO:0007272)3.34039971
9axon ensheathment (GO:0008366)3.34039971
10synaptic vesicle docking involved in exocytosis (GO:0016081)3.20639611
11chromosome organization involved in meiosis (GO:0070192)3.18821304
12asymmetric protein localization (GO:0008105)3.11761089
13axonal fasciculation (GO:0007413)3.11644841
14dendrite morphogenesis (GO:0048813)3.07820119
15synaptic vesicle maturation (GO:0016188)3.07360192
16embryonic foregut morphogenesis (GO:0048617)3.06701844
17locomotory exploration behavior (GO:0035641)3.06273411
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03020581
19neuron recognition (GO:0008038)3.02336138
20regulation of dendritic spine morphogenesis (GO:0061001)2.99707207
21glutamate secretion (GO:0014047)2.97291766
22presynaptic membrane assembly (GO:0097105)2.95724530
23regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94399280
24vocalization behavior (GO:0071625)2.91116968
25male meiosis I (GO:0007141)2.89253848
26cytoskeletal anchoring at plasma membrane (GO:0007016)2.89052479
27neuron cell-cell adhesion (GO:0007158)2.85539002
28presynaptic membrane organization (GO:0097090)2.85055959
29piRNA metabolic process (GO:0034587)2.84333724
30synaptic vesicle exocytosis (GO:0016079)2.81808727
31cerebellar granule cell differentiation (GO:0021707)2.80945120
32notochord development (GO:0030903)2.80295236
33synaptonemal complex assembly (GO:0007130)2.80007413
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.78099194
35meiotic chromosome segregation (GO:0045132)2.76171353
36male meiosis (GO:0007140)2.75309989
37positive regulation of synapse maturation (GO:0090129)2.72990901
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72926141
39dendritic spine morphogenesis (GO:0060997)2.72635679
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71108296
41regulation of synaptic vesicle exocytosis (GO:2000300)2.68796106
42peripheral nervous system axon ensheathment (GO:0032292)2.67815366
43myelination in peripheral nervous system (GO:0022011)2.67815366
44protein localization to endosome (GO:0036010)2.66557234
45protein localization to synapse (GO:0035418)2.65385475
46mitotic sister chromatid cohesion (GO:0007064)2.64243419
47negative regulation of neurotransmitter secretion (GO:0046929)2.63493124
48synaptonemal complex organization (GO:0070193)2.63429538
49cell migration in hindbrain (GO:0021535)2.63396735
50* establishment of nucleus localization (GO:0040023)2.63138104
51peptidyl-tyrosine autophosphorylation (GO:0038083)2.59567722
52DNA methylation involved in gamete generation (GO:0043046)2.55303347
53negative regulation of neurotransmitter transport (GO:0051589)2.53989238
54regulation of dendritic spine development (GO:0060998)2.52565899
55cerebral cortex radially oriented cell migration (GO:0021799)2.47843874
56neurotransmitter-gated ion channel clustering (GO:0072578)2.47791890
57* ephrin receptor signaling pathway (GO:0048013)2.45978698
58hemidesmosome assembly (GO:0031581)2.45666121
59nerve growth factor signaling pathway (GO:0038180)2.43659777
60negative regulation of catenin import into nucleus (GO:0035414)2.43429294
61dendritic spine organization (GO:0097061)2.42530263
62neuromuscular junction development (GO:0007528)2.42193179
63mating behavior (GO:0007617)2.41886874
64ionotropic glutamate receptor signaling pathway (GO:0035235)2.40236362
65astrocyte development (GO:0014002)2.39361066
66glutamate receptor signaling pathway (GO:0007215)2.38451995
67L-amino acid import (GO:0043092)2.35965263
68regulation of neuronal synaptic plasticity (GO:0048168)2.34853858
69regulation of glutamate receptor signaling pathway (GO:1900449)2.34432828
70hippo signaling (GO:0035329)2.33784618
71regulation of synapse structural plasticity (GO:0051823)2.32900053
72auditory behavior (GO:0031223)2.32231719
73sister chromatid cohesion (GO:0007062)2.31965014
74synaptic transmission, glutamatergic (GO:0035249)2.31624330
75myelin maintenance (GO:0043217)2.31217779
76innervation (GO:0060384)2.30935079
77meiosis I (GO:0007127)2.30060695
78regulation of meiosis I (GO:0060631)2.28236266
79meiotic nuclear division (GO:0007126)2.27940160
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.27272312
81genitalia morphogenesis (GO:0035112)2.27022929
82neuromuscular process controlling balance (GO:0050885)2.26539188
83synapse organization (GO:0050808)2.26520581
84regulation of axon extension involved in axon guidance (GO:0048841)2.26462144
85histone H3-K9 demethylation (GO:0033169)2.25981398
86negative regulation of protein localization to cell surface (GO:2000009)2.25724857
87postsynaptic membrane organization (GO:0001941)2.25438652
88positive regulation of dendrite development (GO:1900006)2.25365477
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.24806125
90nuclear pore complex assembly (GO:0051292)2.24205595
91long-chain fatty acid biosynthetic process (GO:0042759)2.24133845
92oligodendrocyte differentiation (GO:0048709)2.23917906
93semaphorin-plexin signaling pathway (GO:0071526)2.23850524
94embryonic body morphogenesis (GO:0010172)2.22852165
95* negative regulation of axonogenesis (GO:0050771)2.22360820
96regulation of dendrite morphogenesis (GO:0048814)2.21614130
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.21576952
98axon extension (GO:0048675)2.21205381
99polarized epithelial cell differentiation (GO:0030859)2.20699699
100vesicle transport along microtubule (GO:0047496)2.19964500
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.19710714
102neuronal ion channel clustering (GO:0045161)2.19683095
103regulation of long-term neuronal synaptic plasticity (GO:0048169)2.19532737
104establishment of mitochondrion localization (GO:0051654)2.19033964
105anterior/posterior axis specification, embryo (GO:0008595)2.18527871
106organelle transport along microtubule (GO:0072384)2.18190549
107camera-type eye morphogenesis (GO:0048593)2.17473931
108DNA synthesis involved in DNA repair (GO:0000731)2.17171538
109exploration behavior (GO:0035640)2.16911024
110neuron-neuron synaptic transmission (GO:0007270)2.16500530
111negative regulation of keratinocyte proliferation (GO:0010839)2.16256913
112transmission of nerve impulse (GO:0019226)2.16150125
113negative regulation of axon extension (GO:0030517)2.14810957
114eye photoreceptor cell differentiation (GO:0001754)2.14419379
115photoreceptor cell differentiation (GO:0046530)2.14419379
116regulation of hippo signaling (GO:0035330)2.13897441
117body morphogenesis (GO:0010171)2.13689202
118positive regulation of dendritic spine development (GO:0060999)2.13545116
119regulation of centriole replication (GO:0046599)2.12436406
120renal filtration (GO:0097205)2.12320462
121positive regulation of dendrite morphogenesis (GO:0050775)2.12284510
122endocardial cushion development (GO:0003197)2.12150255
123lens fiber cell development (GO:0070307)2.12047355
124central nervous system projection neuron axonogenesis (GO:0021952)2.10726898
125regulation of excitatory postsynaptic membrane potential (GO:0060079)2.10584483
126regulation of synaptic plasticity (GO:0048167)2.10287483
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.09653618
128reciprocal meiotic recombination (GO:0007131)2.09510811
129reciprocal DNA recombination (GO:0035825)2.09510811
130membrane assembly (GO:0071709)2.09155865
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.08398343
132stress fiber assembly (GO:0043149)2.07814211
133embryonic retina morphogenesis in camera-type eye (GO:0060059)2.06173940
134negative regulation of gene silencing (GO:0060969)2.05524404
135nuclear pore organization (GO:0006999)2.04373667
136meiotic cell cycle process (GO:1903046)2.02919330
137retina vasculature morphogenesis in camera-type eye (GO:0061299)2.02357170
138artery development (GO:0060840)2.00651506
139dorsal/ventral axis specification (GO:0009950)2.00643311
140limb development (GO:0060173)1.96541963
141appendage development (GO:0048736)1.96541963
142regulation of transforming growth factor beta2 production (GO:0032909)1.96443972
143suckling behavior (GO:0001967)1.96253731
144neuron projection extension involved in neuron projection guidance (GO:1902284)1.94220766
145axon extension involved in axon guidance (GO:0048846)1.94220766
146regulation of centrosome duplication (GO:0010824)1.93631997
147regulation of DNA endoreduplication (GO:0032875)1.91751318
148negative regulation of cytosolic calcium ion concentration (GO:0051481)1.90961304
149establishment of planar polarity (GO:0001736)1.90443877
150establishment of tissue polarity (GO:0007164)1.90443877
151anatomical structure arrangement (GO:0048532)1.90161668
152sex differentiation (GO:0007548)1.89777309
153righting reflex (GO:0060013)1.89569091
154intraciliary transport (GO:0042073)1.89530249
155macroautophagy (GO:0016236)1.89477111
156limb bud formation (GO:0060174)1.88362585
157reproductive system development (GO:0061458)1.87751497
158nonmotile primary cilium assembly (GO:0035058)1.84808005
159ectoderm development (GO:0007398)1.84717898
160regulation of axon guidance (GO:1902667)1.82881105
161positive regulation of catenin import into nucleus (GO:0035413)1.82161819
162negative regulation of axon guidance (GO:1902668)1.80987832
163negative regulation of chondrocyte differentiation (GO:0032331)1.79030048
164synaptic vesicle endocytosis (GO:0048488)1.78280375
165embryonic heart tube development (GO:0035050)1.77884123
166gene silencing by RNA (GO:0031047)1.76826589
167NLS-bearing protein import into nucleus (GO:0006607)1.76306767
168regulation of protein polyubiquitination (GO:1902914)1.76096377
169vascular smooth muscle contraction (GO:0014829)1.75373929
170cerebral cortex development (GO:0021987)1.74607187
171morphogenesis of an epithelial sheet (GO:0002011)1.74583312
172biotin metabolic process (GO:0006768)1.74348056
173positive regulation of meiosis (GO:0045836)1.74073439
174negative regulation of dendrite morphogenesis (GO:0050774)1.73851644
175regulation of centrosome cycle (GO:0046605)1.73467761
176histone H3-K36 demethylation (GO:0070544)1.72867424
177regulation of gene silencing by miRNA (GO:0060964)1.72335644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.17145514
2* GBX2_23144817_ChIP-Seq_PC3_Human2.96250361
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54442702
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42986011
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37156218
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37156218
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33461310
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27999047
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.20148913
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19541652
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.15622488
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13531966
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08909774
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08652608
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04522046
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98269866
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.97132094
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96939318
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.90473264
20DROSHA_22980978_ChIP-Seq_HELA_Human1.82224475
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79387124
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78903783
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76290522
24* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73765246
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.68329887
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.68048254
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.66284207
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64181473
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63977917
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.63357804
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62702141
32* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59803118
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59513241
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59336068
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57070335
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56766301
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52422990
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50170417
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43717814
40AR_21572438_ChIP-Seq_LNCaP_Human1.43362615
41* TP53_16413492_ChIP-PET_HCT116_Human1.41827704
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41703772
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40881107
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39205235
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38599079
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.38480915
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.38339551
48RNF2_27304074_Chip-Seq_NSC_Mouse1.37628696
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.35689939
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35073725
51IGF1R_20145208_ChIP-Seq_DFB_Human1.35048529
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34504051
53AR_21909140_ChIP-Seq_LNCAP_Human1.34274458
54FUS_26573619_Chip-Seq_HEK293_Human1.32543661
55AHR_22903824_ChIP-Seq_MCF-7_Human1.32340493
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32150014
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.32131265
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31849005
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.31521300
60* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31035093
61EWS_26573619_Chip-Seq_HEK293_Human1.29504962
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29060858
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27869956
64REST_21632747_ChIP-Seq_MESCs_Mouse1.24712483
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24499466
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23529047
67SMAD4_21799915_ChIP-Seq_A2780_Human1.23457798
68STAT3_23295773_ChIP-Seq_U87_Human1.22534120
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.22474562
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22258236
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.22088723
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.21697920
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.21525599
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20173050
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19558928
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.19453611
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19032154
78* AR_25329375_ChIP-Seq_VCAP_Human1.19011350
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16448211
80* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15861506
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15167543
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13819299
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13664209
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12712893
85ZNF274_21170338_ChIP-Seq_K562_Hela1.12221780
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.12138345
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11080520
88AR_19668381_ChIP-Seq_PC3_Human1.10848792
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10452727
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08239888
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07751857
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07751857
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07673168
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06101050
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.05767954
96TP53_18474530_ChIP-ChIP_U2OS_Human1.05301117
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.04931944
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04898885
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03975860
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03232924
101P300_19829295_ChIP-Seq_ESCs_Human1.03130413
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.03083905
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02713274
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02620748
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02183524
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01910957
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01666882
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01511535
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01063274
110TAF15_26573619_Chip-Seq_HEK293_Human1.01035123
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00658926
112* TCF4_23295773_ChIP-Seq_U87_Human1.00082427
113* KDM2B_26808549_Chip-Seq_K562_Human0.99802809
114VDR_22108803_ChIP-Seq_LS180_Human0.99185728
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99165664
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.98903598
117BCAT_22108803_ChIP-Seq_LS180_Human0.98859755
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98615371
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.98366215
120FOXM1_23109430_ChIP-Seq_U2OS_Human0.97762357
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96992992
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96796324
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.95531277
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.94918854
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.94706014
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94472003
127ER_23166858_ChIP-Seq_MCF-7_Human0.93818536
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93686896
129SOX9_26525672_Chip-Seq_HEART_Mouse0.93675915
130* CJUN_26792858_Chip-Seq_BT549_Human0.92653615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.70571066
2MP0004270_analgesia2.87335197
3MP0003880_abnormal_central_pattern2.69555178
4MP0005623_abnormal_meninges_morphology2.59113493
5MP0004272_abnormal_basement_membrane2.34753463
6MP0008877_abnormal_DNA_methylation2.27225237
7MP0003635_abnormal_synaptic_transmissio2.18271292
8MP0000537_abnormal_urethra_morphology2.12853036
9MP0000566_synostosis2.10431768
10MP0000778_abnormal_nervous_system2.06179761
11MP0008438_abnormal_cutaneous_collagen1.96776954
12MP0009780_abnormal_chondrocyte_physiolo1.88750512
13MP0005171_absent_coat_pigmentation1.88463169
14MP0002063_abnormal_learning/memory/cond1.81227453
15MP0001486_abnormal_startle_reflex1.70832949
16MP0004885_abnormal_endolymph1.69033397
17MP0002064_seizures1.62212117
18MP0009745_abnormal_behavioral_response1.58787280
19MP0003329_amyloid_beta_deposits1.57995078
20MP0010030_abnormal_orbit_morphology1.57727395
21MP0001299_abnormal_eye_distance/1.57598310
22MP0000920_abnormal_myelination1.49761347
23MP0003941_abnormal_skin_development1.49352125
24MP0000579_abnormal_nail_morphology1.49157172
25MP0003950_abnormal_plasma_membrane1.46844404
26MP0000534_abnormal_ureter_morphology1.42494852
27MP0002734_abnormal_mechanical_nocicepti1.42476675
28MP0003122_maternal_imprinting1.42233532
29MP0001984_abnormal_olfaction1.39918729
30MP0003385_abnormal_body_wall1.38111703
31MP0000751_myopathy1.36227588
32MP0005409_darkened_coat_color1.35542544
33MP0003705_abnormal_hypodermis_morpholog1.35440407
34MP0002272_abnormal_nervous_system1.34702856
35MP0002572_abnormal_emotion/affect_behav1.32339960
36MP0010368_abnormal_lymphatic_system1.32031641
37MP0000955_abnormal_spinal_cord1.31571732
38MP0009250_abnormal_appendicular_skeleto1.30045764
39* MP0003937_abnormal_limbs/digits/tail_de1.27585235
40MP0002697_abnormal_eye_size1.24711725
41MP0009046_muscle_twitch1.23191697
42MP0005187_abnormal_penis_morphology1.20812496
43* MP0002084_abnormal_developmental_patter1.19574454
44MP0003632_abnormal_nervous_system1.18535908
45MP0001440_abnormal_grooming_behavior1.18419558
46MP0001177_atelectasis1.17394208
47MP0002938_white_spotting1.15784065
48MP0000569_abnormal_digit_pigmentation1.15544297
49MP0002882_abnormal_neuron_morphology1.14311246
50* MP0003634_abnormal_glial_cell1.13374033
51MP0000013_abnormal_adipose_tissue1.12591369
52MP0003755_abnormal_palate_morphology1.12413084
53MP0009384_cardiac_valve_regurgitation1.12081241
54MP0003123_paternal_imprinting1.10756790
55MP0004233_abnormal_muscle_weight1.10707009
56* MP0003861_abnormal_nervous_system1.10332189
57MP0002160_abnormal_reproductive_system1.10051238
58* MP0002152_abnormal_brain_morphology1.08358729
59MP0000733_abnormal_muscle_development1.07728856
60MP0000462_abnormal_digestive_system1.06888234
61MP0005248_abnormal_Harderian_gland1.06426234
62MP0001293_anophthalmia1.06117760
63MP0006138_congestive_heart_failure1.05571619
64MP0004145_abnormal_muscle_electrophysio1.05506850
65MP0003942_abnormal_urinary_system1.04826919
66MP0002234_abnormal_pharynx_morphology1.04302723
67MP0003121_genomic_imprinting1.03798009
68* MP0010678_abnormal_skin_adnexa1.03426765
69MP0004858_abnormal_nervous_system1.02982409
70MP0003091_abnormal_cell_migration1.02748098
71MP0002210_abnormal_sex_determination1.02536425
72MP0003283_abnormal_digestive_organ1.01866731
73* MP0002184_abnormal_innervation1.01232823
74MP0002249_abnormal_larynx_morphology1.00480220
75MP0004811_abnormal_neuron_physiology0.99429835
76MP0003690_abnormal_glial_cell0.98783183
77* MP0000383_abnormal_hair_follicle0.98441314
78MP0001968_abnormal_touch/_nociception0.97705912
79MP0003136_yellow_coat_color0.96976548
80MP0002295_abnormal_pulmonary_circulatio0.96607026
81MP0009703_decreased_birth_body0.95988026
82MP0003935_abnormal_craniofacial_develop0.95309685
83MP0001485_abnormal_pinna_reflex0.95001700
84MP0000428_abnormal_craniofacial_morphol0.93344497
85* MP0003115_abnormal_respiratory_system0.93037903
86MP0002067_abnormal_sensory_capabilities0.92950975
87MP0005503_abnormal_tendon_morphology0.92533943
88MP0004133_heterotaxia0.92129963
89MP0001879_abnormal_lymphatic_vessel0.91583608
90MP0000003_abnormal_adipose_tissue0.90840648
91MP0002653_abnormal_ependyma_morphology0.90816955
92MP0003890_abnormal_embryonic-extraembry0.90470646
93MP0000762_abnormal_tongue_morphology0.89848435
94MP0002066_abnormal_motor_capabilities/c0.89819972
95MP0001529_abnormal_vocalization0.89678209
96* MP0002085_abnormal_embryonic_tissue0.89121530
97MP0004924_abnormal_behavior0.88466490
98MP0005386_behavior/neurological_phenoty0.88466490
99MP0000631_abnormal_neuroendocrine_gland0.87729107
100MP0002909_abnormal_adrenal_gland0.87532541
101MP0001286_abnormal_eye_development0.87294139
102MP0003787_abnormal_imprinting0.87014830
103* MP0004085_abnormal_heartbeat0.85267204
104MP0002736_abnormal_nociception_after0.85028100
105MP0010352_gastrointestinal_tract_polyps0.84877236
106* MP0003119_abnormal_digestive_system0.84318595
107MP0001929_abnormal_gametogenesis0.83918928
108MP0003698_abnormal_male_reproductive0.83729000
109MP0005423_abnormal_somatic_nervous0.83536180
110MP0004134_abnormal_chest_morphology0.83359705
111MP0002089_abnormal_postnatal_growth/wei0.83356679
112MP0003631_nervous_system_phenotype0.83345463
113* MP0000647_abnormal_sebaceous_gland0.83233994
114MP0003137_abnormal_impulse_conducting0.83124269
115MP0005167_abnormal_blood-brain_barrier0.83077294
116MP0001958_emphysema0.82531547
117MP0001849_ear_inflammation0.82382491
118MP0002557_abnormal_social/conspecific_i0.82324654
119MP0003279_aneurysm0.82314058
120MP0002116_abnormal_craniofacial_bone0.82055830
121MP0010234_abnormal_vibrissa_follicle0.81861949
122MP0009053_abnormal_anal_canal0.81640230
123MP0000049_abnormal_middle_ear0.81231879
124MP0004215_abnormal_myocardial_fiber0.80921297
125MP0002233_abnormal_nose_morphology0.80730663
126* MP0000432_abnormal_head_morphology0.78804157
127MP0004084_abnormal_cardiac_muscle0.78135626
128MP0001145_abnormal_male_reproductive0.77526163
129MP0008932_abnormal_embryonic_tissue0.77515484
130MP0004742_abnormal_vestibular_system0.77262121
131MP0002108_abnormal_muscle_morphology0.77216228
132MP0005551_abnormal_eye_electrophysiolog0.76542691
133MP0002282_abnormal_trachea_morphology0.75490060
134MP0006276_abnormal_autonomic_nervous0.75181465
135MP0001943_abnormal_respiration0.74655131
136MP0003566_abnormal_cell_adhesion0.73871633
137MP0002081_perinatal_lethality0.73285053
138MP0000653_abnormal_sex_gland0.71731845
139MP0005257_abnormal_intraocular_pressure0.71369354
140MP0005253_abnormal_eye_physiology0.70464452
141* MP0000427_abnormal_hair_cycle0.70229302
142MP0009697_abnormal_copulation0.70131575
143MP0002111_abnormal_tail_morphology0.69022661

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)3.44461375
2Cerebral inclusion bodies (HP:0100314)3.42998652
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07293050
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.07293050
5Insidious onset (HP:0003587)3.00596181
6Termporal pattern (HP:0011008)3.00596181
7Shallow orbits (HP:0000586)2.79609364
8Aplasia involving bones of the upper limbs (HP:0009823)2.76297375
9Aplasia of the phalanges of the hand (HP:0009802)2.76297375
10Aplasia involving bones of the extremities (HP:0009825)2.76297375
11Abnormality of the corticospinal tract (HP:0002492)2.67677784
12Premature rupture of membranes (HP:0001788)2.56509543
13Myokymia (HP:0002411)2.50978085
14Coronal craniosynostosis (HP:0004440)2.46752575
15Focal seizures (HP:0007359)2.30804139
16Megalencephaly (HP:0001355)2.30481475
17Focal motor seizures (HP:0011153)2.30374157
18Buphthalmos (HP:0000557)2.29123276
19Sensory axonal neuropathy (HP:0003390)2.26514678
20Epileptic encephalopathy (HP:0200134)2.17716458
21Dysmetria (HP:0001310)2.10527331
22Supranuclear gaze palsy (HP:0000605)2.10487406
23Dysdiadochokinesis (HP:0002075)2.09870674
24Protrusio acetabuli (HP:0003179)2.05558365
25Action tremor (HP:0002345)2.05250698
26Abnormality of dentin (HP:0010299)2.04217802
27Ankle clonus (HP:0011448)2.03931608
28Bronchomalacia (HP:0002780)2.03064691
29Shoulder girdle muscle weakness (HP:0003547)2.02658193
30Intention tremor (HP:0002080)2.02298248
31Bell-shaped thorax (HP:0001591)1.99364394
32Occipital encephalocele (HP:0002085)1.98493025
33Atonic seizures (HP:0010819)1.97104909
34Broad metatarsal (HP:0001783)1.95716854
35Alacrima (HP:0000522)1.95275649
36Volvulus (HP:0002580)1.94145482
37Hypoplastic labia majora (HP:0000059)1.93870401
38Oligodactyly (hands) (HP:0001180)1.92784806
39Spastic gait (HP:0002064)1.92584941
40Increased nuchal translucency (HP:0010880)1.91926392
41Horizontal nystagmus (HP:0000666)1.89586631
42Aplasia/Hypoplasia of the sternum (HP:0006714)1.89417069
43Relative macrocephaly (HP:0004482)1.89226509
44Scapular winging (HP:0003691)1.86775770
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86596531
46Lower limb muscle weakness (HP:0007340)1.86247736
47Urinary urgency (HP:0000012)1.83608259
48Abnormality of the ischium (HP:0003174)1.81696489
49Bladder diverticulum (HP:0000015)1.77654623
50Short nail (HP:0001799)1.76965021
51Tubulointerstitial nephritis (HP:0001970)1.76791959
52Broad-based gait (HP:0002136)1.75756382
53Increased variability in muscle fiber diameter (HP:0003557)1.75464550
54Overgrowth (HP:0001548)1.74998078
55Esophageal atresia (HP:0002032)1.73832812
56Thickened helices (HP:0000391)1.72572358
57Missing ribs (HP:0000921)1.72313424
58Hammertoe (HP:0001765)1.71736536
59Arterial tortuosity (HP:0005116)1.71562342
60Aqueductal stenosis (HP:0002410)1.71526501
61Hypoplasia of the iris (HP:0007676)1.71108575
62Abnormality of the labia majora (HP:0012881)1.70297333
63Onion bulb formation (HP:0003383)1.70119989
64Vascular tortuosity (HP:0004948)1.69995217
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69641077
66Short 4th metacarpal (HP:0010044)1.69641077
67Hypoplastic pelvis (HP:0008839)1.69578926
68Astrocytoma (HP:0009592)1.67796344
69Abnormality of the astrocytes (HP:0100707)1.67796344
70Impaired vibration sensation in the lower limbs (HP:0002166)1.67409968
71Cutaneous syndactyly (HP:0012725)1.67208789
72Scanning speech (HP:0002168)1.65906883
73Difficulty running (HP:0009046)1.65871002
74Abnormality of the lower motor neuron (HP:0002366)1.65685121
75Genital tract atresia (HP:0001827)1.65014344
76Short hallux (HP:0010109)1.64571733
77Gait imbalance (HP:0002141)1.63748656
78Vaginal atresia (HP:0000148)1.63451640
79Preaxial hand polydactyly (HP:0001177)1.62547704
80Vertebral arch anomaly (HP:0008438)1.61606443
81Back pain (HP:0003418)1.61416728
82Hyperventilation (HP:0002883)1.61223686
83Drooling (HP:0002307)1.60660275
84Excessive salivation (HP:0003781)1.60660275
85Clumsiness (HP:0002312)1.60611536
86Abnormal auditory evoked potentials (HP:0006958)1.59791030
87Anophthalmia (HP:0000528)1.58716498
88Decreased lacrimation (HP:0000633)1.58020794
89Nephronophthisis (HP:0000090)1.57621390
90Urinary bladder sphincter dysfunction (HP:0002839)1.57570192
91Hypoplastic ischia (HP:0003175)1.57406340
92Cystic liver disease (HP:0006706)1.57160858
93Macroorchidism (HP:0000053)1.56966696
94Cerebellar dysplasia (HP:0007033)1.56763660
95Hyperextensible skin (HP:0000974)1.56762717
96Mixed hearing impairment (HP:0000410)1.56369766
97Congenital primary aphakia (HP:0007707)1.55758740
98Labial hypoplasia (HP:0000066)1.54395957
99Turricephaly (HP:0000262)1.54273052
100Abnormality of the dental root (HP:0006486)1.54131555
101Taurodontia (HP:0000679)1.54131555
102Abnormality of permanent molar morphology (HP:0011071)1.54131555
103Aplasia/Hypoplasia of the hallux (HP:0008362)1.53605601
104Rimmed vacuoles (HP:0003805)1.53176892
105Anteriorly placed anus (HP:0001545)1.52444838
106Arnold-Chiari malformation (HP:0002308)1.52421914
107Overriding aorta (HP:0002623)1.51483631
108Abnormality of the renal medulla (HP:0100957)1.51221519
109Fibular hypoplasia (HP:0003038)1.51217077
110Intellectual disability, moderate (HP:0002342)1.50278176
111Myelomeningocele (HP:0002475)1.50227495
112Hemiparesis (HP:0001269)1.50106072
113Progressive cerebellar ataxia (HP:0002073)1.49205322
114Insomnia (HP:0100785)1.49060856
115Oligodactyly (HP:0012165)1.48954678
116Humeroradial synostosis (HP:0003041)1.48457645
117Synostosis involving the elbow (HP:0003938)1.48457645
118Cerebral aneurysm (HP:0004944)1.48260429
119Papillary thyroid carcinoma (HP:0002895)1.48147343
120Absent speech (HP:0001344)1.47856018
121Ankle contracture (HP:0006466)1.47414549
122Lower limb amyotrophy (HP:0007210)1.47092006
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.47088569
124Poor coordination (HP:0002370)1.46277827
125Amblyopia (HP:0000646)1.45580766
126Broad distal phalanx of finger (HP:0009836)1.44582786
127Infantile muscular hypotonia (HP:0008947)1.44542322
128Neoplasm of the heart (HP:0100544)1.44469826
129Hyporeflexia of lower limbs (HP:0002600)1.43976441
130Cutaneous finger syndactyly (HP:0010554)1.43248188
131Gastrointestinal atresia (HP:0002589)1.43080543
132Abnormality of the labia minora (HP:0012880)1.43045513
133Abnormality of molar (HP:0011077)1.42895433
134Abnormality of molar morphology (HP:0011070)1.42895433
135High anterior hairline (HP:0009890)1.42804598
136Hypoplastic female external genitalia (HP:0012815)1.41694942
137Bifid tongue (HP:0010297)1.41379469
138Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.41112450
139Congenital glaucoma (HP:0001087)1.40943230
140Aortic dissection (HP:0002647)1.40888664
141Abnormality of the 4th metacarpal (HP:0010012)1.40735541
142Vertebral clefting (HP:0008428)1.40586099
143Spinal rigidity (HP:0003306)1.40297401
144Gaze-evoked nystagmus (HP:0000640)1.40215223
145Aplasia/Hypoplasia of the fibula (HP:0006492)1.39982171
146Muscle fiber splitting (HP:0003555)1.39911058
147Midline defect of the nose (HP:0004122)1.39852932
148Chin dimple (HP:0010751)1.39213368
149Renal hypoplasia (HP:0000089)1.38840860
150Preaxial foot polydactyly (HP:0001841)1.38360827
151Ependymoma (HP:0002888)1.37773669
152Hypopigmentation of the fundus (HP:0007894)1.37502197
153Medial flaring of the eyebrow (HP:0010747)1.37023063
154Chronic hepatic failure (HP:0100626)1.36363332
155Glioma (HP:0009733)1.35313118
156Optic nerve hypoplasia (HP:0000609)1.34735463
157Abnormality of the dental pulp (HP:0006479)1.34354180
158Non-midline cleft lip (HP:0100335)1.33227708
159Limb-girdle muscle weakness (HP:0003325)1.32903622
160Tubular atrophy (HP:0000092)1.32455458
161True hermaphroditism (HP:0010459)1.31541601
162Nephrogenic diabetes insipidus (HP:0009806)1.31399080
163Type II lissencephaly (HP:0007260)1.31296997
164Gonadotropin excess (HP:0000837)1.30954477
165Pancreatic fibrosis (HP:0100732)1.30216406
166Abnormality of the proximal phalanges of the hand (HP:0009834)1.29340241
167Intestinal atresia (HP:0011100)1.29163678
168Tracheomalacia (HP:0002779)1.28880370
169Ectopic kidney (HP:0000086)1.26929537
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.26475097
171Gastroesophageal reflux (HP:0002020)1.26239495
172Hepatoblastoma (HP:0002884)1.24704180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK392.98242995
2EPHA42.89769873
3MST1R2.42974589
4OXSR12.29098459
5PAK62.27209801
6BCR2.07417638
7DDR22.01882121
8LATS21.98482809
9MARK11.94026748
10PRKD31.93221723
11NTRK31.84251770
12LATS11.78654056
13TYRO31.74521121
14MAP3K41.73297417
15CASK1.71944455
16MAP3K91.71142529
17FGFR21.69418548
18NTRK11.64549755
19DAPK21.58120740
20FER1.58074271
21DMPK1.56516502
22PRPF4B1.54432001
23WEE11.52652162
24PNCK1.51859753
25ICK1.51293796
26TSSK61.48544496
27PAK31.44603997
28PLK21.38213022
29KSR11.37624296
30KSR21.36875308
31PDGFRA1.34168893
32MINK11.33501213
33WNK41.27450041
34NEK11.24247666
35WNK11.22986617
36CDK191.22613036
37LIMK11.19616075
38UHMK11.19379046
39ROCK21.18838084
40TTK1.17998032
41EPHB21.11957193
42CSNK1A1L1.11648687
43PBK1.10488454
44BRSK21.09574176
45* CDK51.08923221
46CDK141.08634619
47CAMK2B1.01544626
48CDK151.01437615
49CSNK1G21.00640049
50CDK181.00394573
51BMPR1B0.99710719
52STK30.99339994
53TNIK0.97930840
54MKNK20.96893139
55NTRK20.96883930
56WNK30.96650227
57CAMK1G0.95638320
58FRK0.93297657
59TTN0.93128685
60NEK60.90852554
61PKN10.90216556
62MAP3K20.87687054
63SGK4940.87658257
64SGK2230.87658257
65PLK40.86521249
66PAK20.85870380
67CDK11A0.85474678
68FGFR10.84343355
69ERBB30.84338041
70RIPK10.82440455
71CSNK1G30.82248720
72TIE10.80895517
73ERBB40.78215587
74PHKG10.77312380
75PHKG20.77312380
76* CAMK2A0.77084836
77BRD40.76105137
78BRSK10.74960459
79MAPK130.74203439
80TRIM280.73759962
81NEK20.72381845
82CAMKK10.71752684
83CAMK2D0.71166468
84YES10.71151280
85MARK20.70696894
86MKNK10.69382047
87PLK10.69229413
88SRPK10.67384701
89* PTK2B0.66582902
90CSNK1G10.65631642
91STK38L0.65166203
92PLK30.64169425
93AKT30.60772473
94STK380.60380151
95PRKCE0.60332773
96* PTK20.60019898
97STK110.58565310
98TAF10.58284103
99LMTK20.57803953
100EPHA20.57401421
101* MET0.56393159
102* ROCK10.56003290
103DYRK1A0.55861141
104PRKD10.55368919
105CSNK1D0.53735715
106CSNK1E0.53258351
107CDC42BPA0.53182625
108MST40.52732856
109ERBB20.52415213
110PDK30.52360109
111PDK40.52360109
112PRKCH0.52346683
113TRIB30.51917801
114DYRK20.51667410
115MOS0.51619337
116MAP2K10.51054667
117PRKCI0.50278714
118MAP2K40.50252978
119MAP2K70.49287119
120DAPK30.49272773
121MAPK100.48465442
122EPHB10.47727968
123ATM0.46685496
124INSRR0.46168331
125PRKCG0.45990909
126PAK40.45788895
127* PDGFRB0.45758387
128PTK60.45715556
129CAMK1D0.45340884
130NEK90.44887033
131ACVR1B0.44252429
132MAPK150.44109624
133MTOR0.43772144
134SGK10.43703001
135ILK0.43631163
136STK240.42909676
137SGK20.42841983
138PINK10.42219095

Predicted pathways (KEGG)

RankGene SetZ-score
1* Axon guidance_Homo sapiens_hsa043602.25987542
2Nicotine addiction_Homo sapiens_hsa050332.01270160
3Circadian entrainment_Homo sapiens_hsa047131.93537484
4Glutamatergic synapse_Homo sapiens_hsa047241.91554814
5Long-term potentiation_Homo sapiens_hsa047201.80444559
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75822463
7GABAergic synapse_Homo sapiens_hsa047271.73431491
8Synaptic vesicle cycle_Homo sapiens_hsa047211.72769320
9Tight junction_Homo sapiens_hsa045301.68085130
10Amphetamine addiction_Homo sapiens_hsa050311.66355585
11Morphine addiction_Homo sapiens_hsa050321.58876731
12Hippo signaling pathway_Homo sapiens_hsa043901.58110712
13Salivary secretion_Homo sapiens_hsa049701.57136720
14Dopaminergic synapse_Homo sapiens_hsa047281.56351734
15Gap junction_Homo sapiens_hsa045401.55800092
16Renin secretion_Homo sapiens_hsa049241.55165399
17Long-term depression_Homo sapiens_hsa047301.54921462
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52609313
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52247830
20ECM-receptor interaction_Homo sapiens_hsa045121.49930425
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44875543
22Oxytocin signaling pathway_Homo sapiens_hsa049211.42789422
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42459875
24Gastric acid secretion_Homo sapiens_hsa049711.40723257
25Hedgehog signaling pathway_Homo sapiens_hsa043401.40685026
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40589527
27Dorso-ventral axis formation_Homo sapiens_hsa043201.37932377
28Dilated cardiomyopathy_Homo sapiens_hsa054141.36545507
29Basal cell carcinoma_Homo sapiens_hsa052171.34857527
30Renal cell carcinoma_Homo sapiens_hsa052111.32647074
31Melanogenesis_Homo sapiens_hsa049161.29766827
32* Focal adhesion_Homo sapiens_hsa045101.29363811
33Olfactory transduction_Homo sapiens_hsa047401.27237211
34Insulin secretion_Homo sapiens_hsa049111.26156814
35Adherens junction_Homo sapiens_hsa045201.25414992
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25053431
37Cholinergic synapse_Homo sapiens_hsa047251.25047213
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.25045959
39Cocaine addiction_Homo sapiens_hsa050301.23879029
40GnRH signaling pathway_Homo sapiens_hsa049121.21077291
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20785659
42Serotonergic synapse_Homo sapiens_hsa047261.19578304
43Glioma_Homo sapiens_hsa052141.16921741
44Wnt signaling pathway_Homo sapiens_hsa043101.14838694
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14145971
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12397642
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12253990
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11380281
49* ErbB signaling pathway_Homo sapiens_hsa040121.11215759
50Selenocompound metabolism_Homo sapiens_hsa004501.10974989
51Estrogen signaling pathway_Homo sapiens_hsa049151.10924462
52Lysine degradation_Homo sapiens_hsa003101.10669810
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09958259
54cAMP signaling pathway_Homo sapiens_hsa040241.07856613
55Ether lipid metabolism_Homo sapiens_hsa005651.07166178
56Oocyte meiosis_Homo sapiens_hsa041141.04913949
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02807566
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02017464
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01268627
60* Proteoglycans in cancer_Homo sapiens_hsa052050.98364836
61Non-homologous end-joining_Homo sapiens_hsa034500.97613882
62Rap1 signaling pathway_Homo sapiens_hsa040150.97306837
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.96865919
64Calcium signaling pathway_Homo sapiens_hsa040200.96538996
65Ras signaling pathway_Homo sapiens_hsa040140.96414976
66Steroid biosynthesis_Homo sapiens_hsa001000.93257670
67Cell cycle_Homo sapiens_hsa041100.93074844
68Propanoate metabolism_Homo sapiens_hsa006400.92942283
69mRNA surveillance pathway_Homo sapiens_hsa030150.92352235
70Arginine and proline metabolism_Homo sapiens_hsa003300.89872568
71* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89739157
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89431335
73Fanconi anemia pathway_Homo sapiens_hsa034600.86044080
74Nitrogen metabolism_Homo sapiens_hsa009100.85606868
75* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85382090
76Vibrio cholerae infection_Homo sapiens_hsa051100.85239959
77beta-Alanine metabolism_Homo sapiens_hsa004100.84810915
78Taste transduction_Homo sapiens_hsa047420.84177085
79TGF-beta signaling pathway_Homo sapiens_hsa043500.82344893
80Endocytosis_Homo sapiens_hsa041440.81441759
81RNA transport_Homo sapiens_hsa030130.80867645
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79672781
83N-Glycan biosynthesis_Homo sapiens_hsa005100.79500377
84Bile secretion_Homo sapiens_hsa049760.77798849
85Choline metabolism in cancer_Homo sapiens_hsa052310.76815184
86Histidine metabolism_Homo sapiens_hsa003400.76355406
87Endometrial cancer_Homo sapiens_hsa052130.76279304
88Fatty acid biosynthesis_Homo sapiens_hsa000610.75627243
89MAPK signaling pathway_Homo sapiens_hsa040100.75206536
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73633765
91Fatty acid metabolism_Homo sapiens_hsa012120.72462540
92Type II diabetes mellitus_Homo sapiens_hsa049300.71938702
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71728225
94Basal transcription factors_Homo sapiens_hsa030220.71586227
95Bladder cancer_Homo sapiens_hsa052190.71524722
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71429073
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71230569
98MicroRNAs in cancer_Homo sapiens_hsa052060.71117190
99Vitamin B6 metabolism_Homo sapiens_hsa007500.70869276
100Arginine biosynthesis_Homo sapiens_hsa002200.65251345
101Glucagon signaling pathway_Homo sapiens_hsa049220.64538998
102Pancreatic secretion_Homo sapiens_hsa049720.64352089
103Phototransduction_Homo sapiens_hsa047440.63948445
104Melanoma_Homo sapiens_hsa052180.63115561
105ABC transporters_Homo sapiens_hsa020100.63092999
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.63069651
107Protein digestion and absorption_Homo sapiens_hsa049740.62498931
108Mismatch repair_Homo sapiens_hsa034300.61589522
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61054201
110Alcoholism_Homo sapiens_hsa050340.60954012
111AMPK signaling pathway_Homo sapiens_hsa041520.60326961
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59134893
113Thyroid hormone synthesis_Homo sapiens_hsa049180.58799090
114Nucleotide excision repair_Homo sapiens_hsa034200.58699177
115Ovarian steroidogenesis_Homo sapiens_hsa049130.58351517
116Pyruvate metabolism_Homo sapiens_hsa006200.57994044
117mTOR signaling pathway_Homo sapiens_hsa041500.57520881
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57103929
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55933024
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55805545
121Colorectal cancer_Homo sapiens_hsa052100.55792135
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55089954
123* VEGF signaling pathway_Homo sapiens_hsa043700.54822401
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54604699
125* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54588140
126Homologous recombination_Homo sapiens_hsa034400.54490386
127Collecting duct acid secretion_Homo sapiens_hsa049660.54480016
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.51184817
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50350407
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48651454
131Cardiac muscle contraction_Homo sapiens_hsa042600.48119379
132Circadian rhythm_Homo sapiens_hsa047100.46757194

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