PTK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.39704630
2regulation of posttranscriptional gene silencing (GO:0060147)4.59334441
3regulation of gene silencing by miRNA (GO:0060964)4.59334441
4regulation of gene silencing by RNA (GO:0060966)4.59334441
5bone trabecula formation (GO:0060346)3.99700693
6protein retention in ER lumen (GO:0006621)3.91051994
7protein heterotrimerization (GO:0070208)3.88413088
8regulation of hippo signaling (GO:0035330)3.83818136
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.80628708
10hippo signaling (GO:0035329)3.77308334
11outer ear morphogenesis (GO:0042473)3.65374705
12positive regulation of SMAD protein import into nucleus (GO:0060391)3.63016049
13desmosome organization (GO:0002934)3.61704012
14heterochromatin organization (GO:0070828)3.56670993
15COPI coating of Golgi vesicle (GO:0048205)3.55589204
16Golgi transport vesicle coating (GO:0048200)3.55589204
17pre-miRNA processing (GO:0031054)3.55057217
18* planar cell polarity pathway involved in neural tube closure (GO:0090179)3.54266289
19regulation of SMAD protein import into nucleus (GO:0060390)3.43547908
20multicellular organismal macromolecule metabolic process (GO:0044259)3.40708536
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37094515
22axon extension involved in axon guidance (GO:0048846)3.35583090
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.35583090
24endodermal cell differentiation (GO:0035987)3.33877898
25kidney mesenchyme development (GO:0072074)3.33625846
26* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32406479
27collagen fibril organization (GO:0030199)3.24593973
28tooth mineralization (GO:0034505)3.22349839
29extracellular matrix disassembly (GO:0022617)3.19646394
30multicellular organismal catabolic process (GO:0044243)3.18738679
31metanephric mesenchyme development (GO:0072075)3.17773459
32multicellular organismal metabolic process (GO:0044236)3.16371370
33DNA unwinding involved in DNA replication (GO:0006268)3.15813230
34cell adhesion mediated by integrin (GO:0033627)3.15124134
35negative regulation of chondrocyte differentiation (GO:0032331)3.13745754
36* regulation of establishment of planar polarity (GO:0090175)3.13309643
37nuclear pore organization (GO:0006999)3.11974514
38cell-substrate adherens junction assembly (GO:0007045)3.11699366
39focal adhesion assembly (GO:0048041)3.11699366
40chondrocyte proliferation (GO:0035988)3.11480235
41notochord development (GO:0030903)3.11264899
42lateral sprouting from an epithelium (GO:0060601)3.10757985
43endothelial cell morphogenesis (GO:0001886)3.02751359
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02340669
45craniofacial suture morphogenesis (GO:0097094)3.01974183
46nuclear pore complex assembly (GO:0051292)3.00384965
47anterior/posterior axis specification, embryo (GO:0008595)2.99132148
48anatomical structure regression (GO:0060033)2.97956996
49proximal/distal pattern formation (GO:0009954)2.96110162
50negative regulation of DNA repair (GO:0045738)2.95555665
51glomerular visceral epithelial cell development (GO:0072015)2.95519048
52regulation of translational fidelity (GO:0006450)2.93874903
53mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.92085193
54regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.90646100
55hemidesmosome assembly (GO:0031581)2.88743517
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.87063647
57regulation of cardioblast differentiation (GO:0051890)2.86242792
58* convergent extension (GO:0060026)2.85435862
59* cochlea morphogenesis (GO:0090103)2.85210372
60positive regulation of smoothened signaling pathway (GO:0045880)2.83384263
61endocardial cushion development (GO:0003197)2.82895543
62wound healing, spreading of epidermal cells (GO:0035313)2.81388552
63chondrocyte development (GO:0002063)2.80356512
64protein localization to kinetochore (GO:0034501)2.80067367
65glomerular basement membrane development (GO:0032836)2.80027284
66semaphorin-plexin signaling pathway (GO:0071526)2.79560213
67mesenchymal cell proliferation (GO:0010463)2.79264335
68* polarized epithelial cell differentiation (GO:0030859)2.77697558
69basement membrane organization (GO:0071711)2.77440850
70epithelial cell-cell adhesion (GO:0090136)2.76483568
71peptidyl-proline hydroxylation (GO:0019511)2.76350715
72negative regulation of cell fate specification (GO:0009996)2.75796169
73vascular endothelial growth factor signaling pathway (GO:0038084)2.75649754
74heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.75566090
75* establishment of apical/basal cell polarity (GO:0035089)2.74918150
76negative regulation of embryonic development (GO:0045992)2.74654754
77apoptotic process involved in morphogenesis (GO:0060561)2.74566617
78DNA replication-dependent nucleosome organization (GO:0034723)2.73843235
79DNA replication-dependent nucleosome assembly (GO:0006335)2.73843235
80peptidyl-arginine omega-N-methylation (GO:0035247)2.72668385
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.72600008
82branching involved in salivary gland morphogenesis (GO:0060445)2.71883732
83negative regulation of cartilage development (GO:0061037)2.71182309
84cell migration involved in gastrulation (GO:0042074)2.70877389
85embryonic camera-type eye development (GO:0031076)2.70653177
86extracellular fibril organization (GO:0043206)2.70017827
87cell surface receptor signaling pathway involved in heart development (GO:0061311)2.69745293
88regulation of cell fate specification (GO:0042659)2.69242933
89regulation of heart morphogenesis (GO:2000826)2.68136688
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67806787
91regulation of transforming growth factor beta2 production (GO:0032909)2.67441733
92positive regulation of epithelial to mesenchymal transition (GO:0010718)2.67196079
93glomerular epithelial cell development (GO:0072310)2.67108156
94embryonic skeletal joint morphogenesis (GO:0060272)2.65866133
95organ induction (GO:0001759)2.64757351
96adherens junction assembly (GO:0034333)2.63562556
97cell migration involved in heart development (GO:0060973)2.62761372
98gastrulation with mouth forming second (GO:0001702)2.60182360
99dorsal/ventral axis specification (GO:0009950)2.60150102
100atrioventricular valve morphogenesis (GO:0003181)2.59979472
101negative regulation of catenin import into nucleus (GO:0035414)2.59894686
102extracellular matrix organization (GO:0030198)2.57958935
103negative regulation of fatty acid transport (GO:2000192)2.57649493
104mesodermal cell differentiation (GO:0048333)2.57126612
105extracellular structure organization (GO:0043062)2.57087056
106extracellular matrix assembly (GO:0085029)2.56063177
107regulation of gastrulation (GO:0010470)2.55124736
108sequestering of extracellular ligand from receptor (GO:0035581)2.54943218
109regulation of sister chromatid cohesion (GO:0007063)2.54295823
110positive regulation of catenin import into nucleus (GO:0035413)2.53688902
111chromatin assembly (GO:0031497)2.53540498
112eye morphogenesis (GO:0048592)2.53157654
113positive regulation of endothelial cell apoptotic process (GO:2000353)2.52607834
114substrate adhesion-dependent cell spreading (GO:0034446)2.52331343
115positive regulation of mesenchymal cell proliferation (GO:0002053)2.52267055
116cranial suture morphogenesis (GO:0060363)2.51651389
117nodal signaling pathway (GO:0038092)2.51233732
118* non-canonical Wnt signaling pathway (GO:0035567)2.51102695
119mitotic nuclear envelope disassembly (GO:0007077)2.50698011
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50077574
121* mesenchyme development (GO:0060485)2.49870734
122collagen metabolic process (GO:0032963)2.49689788
123cell-substrate junction assembly (GO:0007044)2.49140974
124cell proliferation involved in metanephros development (GO:0072203)2.48445574
125type B pancreatic cell proliferation (GO:0044342)2.48111009
126regulation of chondrocyte differentiation (GO:0032330)2.47690321
127regulation of cartilage development (GO:0061035)2.47599709
128regulation of catenin import into nucleus (GO:0035412)2.47581187
129muscle cell migration (GO:0014812)2.47519719
130embryonic foregut morphogenesis (GO:0048617)2.47373946
131embryonic hindlimb morphogenesis (GO:0035116)2.47181075
132embryonic cranial skeleton morphogenesis (GO:0048701)2.46680790
133hindlimb morphogenesis (GO:0035137)2.46646315
134regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46598454
135mesenchymal-epithelial cell signaling (GO:0060638)2.45489670
136* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45218980
137regulation of stem cell maintenance (GO:2000036)2.44855651
138bone morphogenesis (GO:0060349)2.44675601
139blood vessel endothelial cell migration (GO:0043534)2.44462912
140heparan sulfate proteoglycan metabolic process (GO:0030201)2.43517609
141negative regulation of stem cell proliferation (GO:2000647)2.43131546
142collagen catabolic process (GO:0030574)2.41798251
143apoptotic cell clearance (GO:0043277)2.41045343
144apoptotic process involved in development (GO:1902742)2.41015505
145cell migration involved in sprouting angiogenesis (GO:0002042)2.39591784
146glucocorticoid receptor signaling pathway (GO:0042921)2.39493503
147cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.39465362
148protein hydroxylation (GO:0018126)2.39364574
149peptidyl-arginine methylation (GO:0018216)2.38464494
150peptidyl-arginine N-methylation (GO:0035246)2.38464494
151skin morphogenesis (GO:0043589)2.38378366
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.38333388
153body morphogenesis (GO:0010171)2.38316965
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36485279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.60384161
2E2F7_22180533_ChIP-Seq_HELA_Human5.08205878
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.75121666
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.90927505
5* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.85842004
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84957096
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84957096
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84957096
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.62950510
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.62287846
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54695845
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.40224821
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37361197
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31333215
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31113172
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.27915998
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24516208
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.17460705
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17044602
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12392352
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09989703
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07656912
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02886505
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.98647245
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98313043
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96137547
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94460735
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92070166
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90438728
30LXR_22292898_ChIP-Seq_THP-1_Human1.88751872
31* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.78058910
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78031691
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76809233
34CLOCK_20551151_ChIP-Seq_293T_Human1.75788967
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74930919
36MYC_22102868_ChIP-Seq_BL_Human1.74343380
37KDM2B_26808549_Chip-Seq_K562_Human1.71626704
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70560104
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69105931
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.67648704
41* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.67560143
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67336546
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66191466
44* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65941546
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65681942
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.63720293
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.63134654
48AR_21909140_ChIP-Seq_LNCAP_Human1.61947303
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.60256878
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59454446
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56835251
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55088612
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52675040
54ZNF263_19887448_ChIP-Seq_K562_Human1.52641028
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52558597
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50542233
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.48270189
58* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.47374553
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46861925
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45731640
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45557552
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.44796289
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44005756
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41602420
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40785437
66* TP53_20018659_ChIP-ChIP_R1E_Mouse1.40731488
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39639092
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39300676
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39300676
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38681182
71ATF3_27146783_Chip-Seq_COLON_Human1.35993260
72XRN2_22483619_ChIP-Seq_HELA_Human1.34962000
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.31935426
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31699633
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31526776
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29428525
77* TP53_23651856_ChIP-Seq_MEFs_Mouse1.28987550
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28792697
79RACK7_27058665_Chip-Seq_MCF-7_Human1.28482406
80* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28350129
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28067035
82TP53_22127205_ChIP-Seq_IMR90_Human1.27515794
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25304697
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24852239
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24360200
86* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24212462
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23514218
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.23414891
89TET1_21490601_ChIP-Seq_MESCs_Mouse1.22850964
90KDM2B_26808549_Chip-Seq_DND41_Human1.19861359
91* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19672910
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19155072
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.18960504
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17979259
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17870410
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17046283
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15505257
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.15388942
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15309938
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15253572
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15159956
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15019226
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14683343
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14601543
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13616498
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12929842
107* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12862968
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12028630
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11999762
110CTCF_27219007_Chip-Seq_Bcells_Human1.11261802
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10783237
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10539462
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10388511
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10388511
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10078080
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09616887
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.09343297
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.08628017
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08549764
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07992758
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07157910
122SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07126624
123SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06526752
124* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06152432
125UBF1/2_26484160_Chip-Seq_HMECs_Human1.04404100
126CHD1_26751641_Chip-Seq_LNCaP_Human1.04390057
127* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04308523
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04301856
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04015587
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03530807
131* CJUN_26792858_Chip-Seq_BT549_Human1.03359494
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02400993
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02190630
134* BRD4_25478319_ChIP-Seq_HGPS_Human1.01559927
135NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01484335
136SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00612213
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98691972
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96422669
139ESR1_21235772_ChIP-Seq_MCF-7_Human0.96226090
140* RUNX1_27514584_Chip-Seq_MCF-7_Human0.96202541
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.94267272
142CREB1_26743006_Chip-Seq_LNCaP_Human0.93039222
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.93025381
144SA1_22415368_ChIP-Seq_MEFs_Mouse0.92665134
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91297683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.16628366
2MP0003705_abnormal_hypodermis_morpholog3.53275979
3MP0010030_abnormal_orbit_morphology3.30089697
4MP0005275_abnormal_skin_tensile2.94561016
5MP0000537_abnormal_urethra_morphology2.53432053
6MP0009053_abnormal_anal_canal2.52823194
7MP0005623_abnormal_meninges_morphology2.52340140
8MP0004272_abnormal_basement_membrane2.47137669
9MP0010352_gastrointestinal_tract_polyps2.42375446
10MP0005503_abnormal_tendon_morphology2.36437471
11MP0003123_paternal_imprinting2.27814560
12MP0003941_abnormal_skin_development2.02693325
13MP0010368_abnormal_lymphatic_system1.91408826
14MP0003283_abnormal_digestive_organ1.91326235
15MP0005076_abnormal_cell_differentiation1.89724825
16MP0003942_abnormal_urinary_system1.88608102
17MP0004858_abnormal_nervous_system1.83070738
18MP0003122_maternal_imprinting1.82496869
19* MP0003385_abnormal_body_wall1.81082467
20MP0003566_abnormal_cell_adhesion1.79734726
21MP0006054_spinal_hemorrhage1.77251386
22MP0000534_abnormal_ureter_morphology1.76782318
23MP0002254_reproductive_system_inflammat1.73819409
24MP0003279_aneurysm1.71978821
25MP0010234_abnormal_vibrissa_follicle1.70928697
26MP0000428_abnormal_craniofacial_morphol1.70587912
27MP0001849_ear_inflammation1.70088160
28MP0003937_abnormal_limbs/digits/tail_de1.69677013
29MP0003119_abnormal_digestive_system1.62035643
30MP0002653_abnormal_ependyma_morphology1.60579290
31MP0000733_abnormal_muscle_development1.60416204
32MP0002932_abnormal_joint_morphology1.59336388
33MP0000579_abnormal_nail_morphology1.58796455
34MP0003115_abnormal_respiratory_system1.58147533
35MP0004197_abnormal_fetal_growth/weight/1.56299776
36MP0005508_abnormal_skeleton_morphology1.55569325
37MP0002282_abnormal_trachea_morphology1.55392560
38MP0002249_abnormal_larynx_morphology1.51435206
39MP0000049_abnormal_middle_ear1.51169382
40MP0004957_abnormal_blastocyst_morpholog1.50498010
41MP0009250_abnormal_appendicular_skeleto1.48878791
42* MP0002084_abnormal_developmental_patter1.46962720
43MP0003755_abnormal_palate_morphology1.44973588
44* MP0002085_abnormal_embryonic_tissue1.44347465
45MP0003121_genomic_imprinting1.43914621
46MP0001958_emphysema1.43882063
47MP0002111_abnormal_tail_morphology1.42417091
48MP0003935_abnormal_craniofacial_develop1.41440756
49MP0002060_abnormal_skin_morphology1.40324121
50MP0005023_abnormal_wound_healing1.36946880
51MP0000762_abnormal_tongue_morphology1.36500675
52MP0001293_anophthalmia1.34589686
53MP0000432_abnormal_head_morphology1.31485199
54MP0004133_heterotaxia1.29027157
55MP0003111_abnormal_nucleus_morphology1.27530258
56MP0001730_embryonic_growth_arrest1.25380150
57MP0000350_abnormal_cell_proliferation1.23935571
58MP0004233_abnormal_muscle_weight1.23852112
59MP0005257_abnormal_intraocular_pressure1.23068531
60MP0002089_abnormal_postnatal_growth/wei1.20994196
61MP0005409_darkened_coat_color1.20950804
62* MP0001672_abnormal_embryogenesis/_devel1.20861766
63* MP0005380_embryogenesis_phenotype1.20861766
64MP0003567_abnormal_fetal_cardiomyocyte1.20688398
65MP0008007_abnormal_cellular_replicative1.20347515
66MP0002697_abnormal_eye_size1.20284687
67MP0001348_abnormal_lacrimal_gland1.20012832
68MP0000751_myopathy1.19818455
69MP0002116_abnormal_craniofacial_bone1.19716323
70MP0003077_abnormal_cell_cycle1.17888224
71MP0000516_abnormal_urinary_system1.17778955
72MP0005367_renal/urinary_system_phenotyp1.17778955
73MP0002233_abnormal_nose_morphology1.17680188
74MP0002086_abnormal_extraembryonic_tissu1.16632836
75MP0001697_abnormal_embryo_size1.16347462
76MP0002088_abnormal_embryonic_growth/wei1.14292994
77MP0003984_embryonic_growth_retardation1.13807294
78MP0008932_abnormal_embryonic_tissue1.12984274
79MP0000467_abnormal_esophagus_morphology1.12544863
80MP0002092_abnormal_eye_morphology1.10855877
81MP0003890_abnormal_embryonic-extraembry1.10578866
82MP0001542_abnormal_bone_strength1.07517659
83MP0009780_abnormal_chondrocyte_physiolo1.05878688
84MP0000013_abnormal_adipose_tissue1.03127906
85MP0002925_abnormal_cardiovascular_devel1.02290569
86MP0001243_abnormal_dermal_layer1.01388132
87* MP0002114_abnormal_axial_skeleton0.99643032
88MP0010307_abnormal_tumor_latency0.99376619
89MP0000003_abnormal_adipose_tissue0.98473035
90MP0009384_cardiac_valve_regurgitation0.98206671
91MP0003091_abnormal_cell_migration0.97881851
92MP0002938_white_spotting0.97775929
93MP0001915_intracranial_hemorrhage0.97005973
94* MP0002109_abnormal_limb_morphology0.96179014
95MP0002295_abnormal_pulmonary_circulatio0.95746189
96MP0002896_abnormal_bone_mineralization0.95476463
97MP0001286_abnormal_eye_development0.94990090
98MP0000462_abnormal_digestive_system0.94885238
99MP0000767_abnormal_smooth_muscle0.93717787
100MP0010094_abnormal_chromosome_stability0.93598784
101MP0002080_prenatal_lethality0.93271080
102MP0002877_abnormal_melanocyte_morpholog0.92906377
103MP0003878_abnormal_ear_physiology0.91621329
104MP0005377_hearing/vestibular/ear_phenot0.91621329
105MP0000566_synostosis0.91556482
106MP0005197_abnormal_uvea_morphology0.90577732
107MP0000163_abnormal_cartilage_morphology0.89494625
108MP0002234_abnormal_pharynx_morphology0.89417919
109MP0003693_abnormal_embryo_hatching0.89033333
110MP0001299_abnormal_eye_distance/0.88809440
111MP0005248_abnormal_Harderian_gland0.88655858
112MP0000678_abnormal_parathyroid_gland0.87075905
113MP0009278_abnormal_bone_marrow0.86137469
114MP0002115_abnormal_skeleton_extremities0.85102394
115MP0003315_abnormal_perineum_morphology0.81799229
116MP0002108_abnormal_muscle_morphology0.81580444
117MP0009703_decreased_birth_body0.81418264
118* MP0001614_abnormal_blood_vessel0.80097205
119MP0004264_abnormal_extraembryonic_tissu0.78727555
120MP0010771_integument_phenotype0.74856089
121MP0005501_abnormal_skin_physiology0.74238837
122MP0002796_impaired_skin_barrier0.73307723
123MP0002098_abnormal_vibrissa_morphology0.71319927
124MP0001879_abnormal_lymphatic_vessel0.70589873
125MP0003950_abnormal_plasma_membrane0.68642467
126MP0002113_abnormal_skeleton_development0.68447003
127MP0002128_abnormal_blood_circulation0.67647571
128MP0001270_distended_abdomen0.65891284
129MP0009672_abnormal_birth_weight0.64305443
130MP0005193_abnormal_anterior_eye0.63309994
131* MP0001340_abnormal_eyelid_morphology0.63243457

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.27223263
2Premature rupture of membranes (HP:0001788)4.75622734
3Shallow orbits (HP:0000586)4.47583336
4Ankle contracture (HP:0006466)3.90510790
5Atrophic scars (HP:0001075)3.84216764
6Short 4th metacarpal (HP:0010044)3.68690019
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.68690019
8Vascular tortuosity (HP:0004948)3.33793011
9Bladder diverticulum (HP:0000015)3.14319767
10Arterial tortuosity (HP:0005116)3.08268053
11Renal duplication (HP:0000075)3.05533117
12Cerebral aneurysm (HP:0004944)3.03458742
13Abnormality of the 4th metacarpal (HP:0010012)3.01365286
14Selective tooth agenesis (HP:0001592)2.97583099
15Broad metatarsal (HP:0001783)2.94699260
16Fragile skin (HP:0001030)2.91671406
17Aortic dissection (HP:0002647)2.77126886
18Soft skin (HP:0000977)2.68824415
19Abnormality of dentin (HP:0010299)2.64479461
20Bowel diverticulosis (HP:0005222)2.64439436
21Genu recurvatum (HP:0002816)2.62988479
22Peritonitis (HP:0002586)2.55935345
23Mitral valve prolapse (HP:0001634)2.49817000
24Ulnar bowing (HP:0003031)2.46619792
25Dilatation of the ascending aorta (HP:0005111)2.41066928
26Vertebral compression fractures (HP:0002953)2.38750363
27Deviation of the hallux (HP:0010051)2.38335458
28Wrist flexion contracture (HP:0001239)2.37846986
29Natal tooth (HP:0000695)2.36258178
30Coronal craniosynostosis (HP:0004440)2.30973027
31Abnormal delivery (HP:0001787)2.28508207
32Neonatal short-limb short stature (HP:0008921)2.27080150
33Blue sclerae (HP:0000592)2.26108523
34Hallux valgus (HP:0001822)2.24111922
35Milia (HP:0001056)2.22817305
36Broad thumb (HP:0011304)2.18030458
37Cervical subluxation (HP:0003308)2.15397474
38Disproportionate tall stature (HP:0001519)2.13836976
39Mesomelia (HP:0003027)2.12392318
40Follicular hyperkeratosis (HP:0007502)2.10399503
41Abnormality of the distal phalanx of the thumb (HP:0009617)2.07431465
42Mitral regurgitation (HP:0001653)2.06946767
43Hyperacusis (HP:0010780)2.02718498
44Type 1 muscle fiber predominance (HP:0003803)2.01960983
45Spinal rigidity (HP:0003306)2.01053517
46Increased connective tissue (HP:0009025)2.00862912
47Broad long bones (HP:0005622)2.00682976
48Rib fusion (HP:0000902)2.00421088
49Ependymoma (HP:0002888)2.00303762
50Mild short stature (HP:0003502)2.00295844
51Advanced eruption of teeth (HP:0006288)1.99142983
52Missing ribs (HP:0000921)1.98810197
53Breech presentation (HP:0001623)1.98670566
54Aortic aneurysm (HP:0004942)1.98273272
55Renovascular hypertension (HP:0100817)1.96965844
56Wormian bones (HP:0002645)1.96340296
57Short 5th finger (HP:0009237)1.96174785
58Turricephaly (HP:0000262)1.93822812
59Osteoarthritis (HP:0002758)1.92778138
60Hypoventilation (HP:0002791)1.92718226
61Broad toe (HP:0001837)1.92489935
62Ectopia lentis (HP:0001083)1.92148227
63Broad phalanges of the hand (HP:0009768)1.91853894
64Astrocytoma (HP:0009592)1.91203125
65Abnormality of the astrocytes (HP:0100707)1.91203125
66Inguinal hernia (HP:0000023)1.89899204
67Abnormality of the parietal bone (HP:0002696)1.89487407
68Premature skin wrinkling (HP:0100678)1.89376574
69Protruding ear (HP:0000411)1.88861543
70Slender build (HP:0001533)1.88172779
71Abnormality of the peritoneum (HP:0002585)1.86993441
72Camptodactyly of toe (HP:0001836)1.85395029
73Pterygium (HP:0001059)1.85244390
74Buphthalmos (HP:0000557)1.84051010
75Overgrowth (HP:0001548)1.82938455
76Broad finger (HP:0001500)1.82779523
77Wide anterior fontanel (HP:0000260)1.82775823
78Arnold-Chiari malformation (HP:0002308)1.82193035
79Bowed forearm bones (HP:0003956)1.81659412
80Bowing of the arm (HP:0006488)1.81659412
81Short nail (HP:0001799)1.81633707
82Broad phalanx (HP:0006009)1.81175353
83Increased variability in muscle fiber diameter (HP:0003557)1.79954242
84Esophageal atresia (HP:0002032)1.79890637
85Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79693098
86Aplasia involving bones of the upper limbs (HP:0009823)1.78468263
87Aplasia of the phalanges of the hand (HP:0009802)1.78468263
88Aplasia involving bones of the extremities (HP:0009825)1.78468263
89Flat cornea (HP:0007720)1.78364607
90Abnormality of the calcaneus (HP:0008364)1.78310214
91Morphological abnormality of the middle ear (HP:0008609)1.78249943
92Hyperextensible skin (HP:0000974)1.78070265
93Aortic regurgitation (HP:0001659)1.77393231
94Trigonocephaly (HP:0000243)1.75966411
95Radial bowing (HP:0002986)1.75803715
96Supernumerary ribs (HP:0005815)1.75647656
97Abnormal ossification of hand bones (HP:0005921)1.74505016
98Thin ribs (HP:0000883)1.74230981
99Broad face (HP:0000283)1.73783095
100Ankyloglossia (HP:0010296)1.73582052
101Deviation of the thumb (HP:0009603)1.73331644
102Joint laxity (HP:0001388)1.73218600
103Short phalanx of the thumb (HP:0009660)1.72809204
104Midface retrusion (HP:0011800)1.72362115
105Shawl scrotum (HP:0000049)1.69012335
106Vertebral fusion (HP:0002948)1.68870417
107Short humerus (HP:0005792)1.68865553
108Flat acetabular roof (HP:0003180)1.68708587
109Coxa vara (HP:0002812)1.68438262
110Spondylolisthesis (HP:0003302)1.68333579
111Mildly elevated creatine phosphokinase (HP:0008180)1.67705469
112Insomnia (HP:0100785)1.67483661
113Abnormality of carpal bone ossification (HP:0006257)1.67014966
114Elbow flexion contracture (HP:0002987)1.66461589
115Fused cervical vertebrae (HP:0002949)1.66322621
116Down-sloping shoulders (HP:0200021)1.66005513
117Aneurysm (HP:0002617)1.65601619
118Medulloblastoma (HP:0002885)1.65290932
119Trismus (HP:0000211)1.65244855
120Distal upper limb amyotrophy (HP:0007149)1.64726198
121Upper limb amyotrophy (HP:0009129)1.64726198
122Long toe (HP:0010511)1.63518988
123Asymmetry of the thorax (HP:0001555)1.63512654
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.63504658
125Osteolytic defects of the hand bones (HP:0009699)1.63504658
126Overriding aorta (HP:0002623)1.63321501
127Arachnodactyly (HP:0001166)1.63259480
128Biconcave vertebral bodies (HP:0004586)1.62912549
129Thin bony cortex (HP:0002753)1.62672776
130Midline defect of the nose (HP:0004122)1.62660637
131Vertebral arch anomaly (HP:0008438)1.62539488
132Aplasia/hypoplasia of the humerus (HP:0006507)1.61961505
133Atresia of the external auditory canal (HP:0000413)1.61762489
134Partial duplication of the phalanx of hand (HP:0009999)1.61751089
135Neoplasm of the oral cavity (HP:0100649)1.61278545
136Colon cancer (HP:0003003)1.61224959
137Nonimmune hydrops fetalis (HP:0001790)1.60139274
138Synostosis of carpal bones (HP:0005048)1.59584301
139Delayed cranial suture closure (HP:0000270)1.59353966
140Bronchomalacia (HP:0002780)1.58996362
141Increased nuchal translucency (HP:0010880)1.58458916
142Preaxial foot polydactyly (HP:0001841)1.58027701
143Abnormality of oral frenula (HP:0000190)1.57953219
144Broad palm (HP:0001169)1.57260278
145Hypoplastic labia majora (HP:0000059)1.57100401
146Abnormality of the acetabulum (HP:0003170)1.56681772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.27655255
2LATS13.08554368
3EPHA23.07956200
4LATS23.04973742
5PDGFRA2.93384090
6DDR22.91176481
7TRIB32.90683165
8PKN22.80531330
9EEF2K2.79882926
10SMG12.58923750
11MAP3K102.54603312
12TTN2.48365505
13FGFR42.33776147
14EPHB22.06320560
15MYLK2.05833261
16PAK42.01839112
17RPS6KB21.95830424
18RIPK11.84022701
19CDC71.77561318
20ICK1.74177354
21BMX1.58848304
22PTK21.57782587
23PAK21.57329546
24PTK61.55156091
25NEK21.54082487
26SIK11.53255722
27FGFR11.51446493
28MTOR1.49362862
29MST1R1.46651475
30TGFBR11.45910407
31STK381.45070386
32PASK1.40247282
33TTK1.35068607
34CDK71.34998059
35MET1.31412743
36FER1.28625431
37NEK11.23858639
38TYRO31.23133312
39STK38L1.14514771
40LRRK21.14235710
41CDK61.13278233
42RPS6KA21.13062015
43STK31.12585018
44BUB11.10544534
45ERN11.07536176
46WEE11.06606189
47FLT31.06468718
48BRD41.06154281
49MAP3K81.05369938
50MKNK11.04725730
51TSSK61.04682304
52SCYL21.01623859
53PDGFRB1.00687017
54NEK90.99717191
55PRKD20.99438951
56AKT30.99177968
57CAMK1G0.98532578
58LMTK20.97337809
59FGFR20.94986131
60ALK0.94271558
61MAP3K60.90732725
62TESK10.86056164
63CDK40.85995107
64PLK10.80697149
65STK100.80526335
66PLK40.76275382
67ILK0.75444744
68AURKB0.74349826
69CHEK10.73430840
70PRKCI0.68221923
71ERBB40.67507778
72FGFR30.67433419
73DYRK1B0.67057153
74MAPKAPK30.66256300
75RPS6KA40.64937368
76ROCK20.63799579
77AKT20.63488701
78CHEK20.63100522
79ATR0.63003428
80DYRK30.62920892
81ERBB20.61832894
82PAK10.60721698
83PLK30.57897750
84PAK30.57821533
85MARK20.57507684
86PRKG20.57268225
87CDK20.56703296
88TESK20.56259080
89LIMK10.51891517
90WNK10.51795516
91MAP3K70.50411587
92PRKD30.50250854
93KSR10.50241046
94RPS6KA60.49361885
95TGFBR20.49046126
96EPHB10.48051990
97PNCK0.47325388
98AURKA0.46851635
99NTRK10.46370462
100MKNK20.45861297
101ATM0.45364803
102DMPK0.44534712
103CSNK1E0.43919399
104CDK80.43281306
105MAPK10.43115105
106STK40.42751351
107CDK90.41999559
108CDK10.40438503
109TLK10.39560010
110KSR20.39497444
111RET0.38568439
112SRPK10.38312288
113MAP2K20.38257058
114ROCK10.37964533
115DAPK30.37918839
116CAMK1D0.37310685
117TRPM70.37283100
118RPS6KC10.36335255
119RPS6KL10.36335255
120AKT10.35625230
121MATK0.35492992
122RPS6KA10.35099487
123KDR0.34255598
124INSR0.33432907
125MELK0.33112571
126PIM10.33022656
127EPHA30.33018871
128CDC42BPA0.32475797
129MAPK150.31959986
130PIM20.30461864
131SRC0.29879594
132GSK3A0.29106829
133ARAF0.26961777
134CLK10.25801450
135MOS0.25682018
136CDK11A0.24716818
137BRAF0.21481918
138CDK150.21335849
139ABL20.21013195
140MAPK90.20735094

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.46198826
2Hedgehog signaling pathway_Homo sapiens_hsa043402.82847362
3ECM-receptor interaction_Homo sapiens_hsa045122.81737078
4Hippo signaling pathway_Homo sapiens_hsa043902.77839412
5Adherens junction_Homo sapiens_hsa045202.27284377
6Bladder cancer_Homo sapiens_hsa052192.15508924
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.13522251
8Focal adhesion_Homo sapiens_hsa045102.08051902
9MicroRNAs in cancer_Homo sapiens_hsa052062.06393774
10Proteoglycans in cancer_Homo sapiens_hsa052052.05389477
11Spliceosome_Homo sapiens_hsa030402.05034832
12RNA transport_Homo sapiens_hsa030132.03588523
13Cell cycle_Homo sapiens_hsa041102.01949361
14TGF-beta signaling pathway_Homo sapiens_hsa043501.93013022
15Small cell lung cancer_Homo sapiens_hsa052221.92687540
16Notch signaling pathway_Homo sapiens_hsa043301.87256311
17DNA replication_Homo sapiens_hsa030301.84903686
18p53 signaling pathway_Homo sapiens_hsa041151.83167961
19Mismatch repair_Homo sapiens_hsa034301.78958257
20Protein digestion and absorption_Homo sapiens_hsa049741.75852103
21One carbon pool by folate_Homo sapiens_hsa006701.67453967
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60887977
23Wnt signaling pathway_Homo sapiens_hsa043101.56696892
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55004931
25mRNA surveillance pathway_Homo sapiens_hsa030151.54927735
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54782458
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.51676624
28Tight junction_Homo sapiens_hsa045301.51010686
29Chronic myeloid leukemia_Homo sapiens_hsa052201.49108520
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43931042
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.40563764
32Pathways in cancer_Homo sapiens_hsa052001.38195693
33Thyroid cancer_Homo sapiens_hsa052161.34615740
34Colorectal cancer_Homo sapiens_hsa052101.34250665
35HTLV-I infection_Homo sapiens_hsa051661.33988565
36Amoebiasis_Homo sapiens_hsa051461.33874135
37Base excision repair_Homo sapiens_hsa034101.32892900
38Melanoma_Homo sapiens_hsa052181.31220601
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26670972
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25023991
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24020087
42Viral carcinogenesis_Homo sapiens_hsa052031.20661909
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20124068
44mTOR signaling pathway_Homo sapiens_hsa041501.18049023
45Endometrial cancer_Homo sapiens_hsa052131.17327817
46Nucleotide excision repair_Homo sapiens_hsa034201.16328780
47Other glycan degradation_Homo sapiens_hsa005111.11759368
48Melanogenesis_Homo sapiens_hsa049161.10386049
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04291526
50Axon guidance_Homo sapiens_hsa043601.02787871
51Prostate cancer_Homo sapiens_hsa052151.02099068
52Ribosome_Homo sapiens_hsa030101.01446636
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00812334
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00622323
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99872286
56Systemic lupus erythematosus_Homo sapiens_hsa053220.97577555
57Viral myocarditis_Homo sapiens_hsa054160.96396438
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90117135
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89824435
60Rap1 signaling pathway_Homo sapiens_hsa040150.89343185
61Prion diseases_Homo sapiens_hsa050200.88920406
62Glioma_Homo sapiens_hsa052140.88404556
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87284940
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.87197674
65Lysine degradation_Homo sapiens_hsa003100.86553712
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85506096
67Pancreatic cancer_Homo sapiens_hsa052120.82457056
68Oocyte meiosis_Homo sapiens_hsa041140.80922823
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79909722
70Dilated cardiomyopathy_Homo sapiens_hsa054140.79329636
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77628732
72Non-small cell lung cancer_Homo sapiens_hsa052230.75951887
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.72952718
74Renal cell carcinoma_Homo sapiens_hsa052110.72850736
75Thyroid hormone synthesis_Homo sapiens_hsa049180.71873672
76HIF-1 signaling pathway_Homo sapiens_hsa040660.71606885
77Galactose metabolism_Homo sapiens_hsa000520.70068515
78RNA degradation_Homo sapiens_hsa030180.70017324
79Shigellosis_Homo sapiens_hsa051310.66238068
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.62013919
81Estrogen signaling pathway_Homo sapiens_hsa049150.61748948
82Fatty acid biosynthesis_Homo sapiens_hsa000610.60569995
83Renin-angiotensin system_Homo sapiens_hsa046140.59648071
84VEGF signaling pathway_Homo sapiens_hsa043700.59377306
85Choline metabolism in cancer_Homo sapiens_hsa052310.59026515
86Endocytosis_Homo sapiens_hsa041440.58967871
87Homologous recombination_Homo sapiens_hsa034400.58459691
88Vibrio cholerae infection_Homo sapiens_hsa051100.57096882
89Alcoholism_Homo sapiens_hsa050340.56245145
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55969198
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.55808486
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55559362
93Pentose phosphate pathway_Homo sapiens_hsa000300.54867972
94Inositol phosphate metabolism_Homo sapiens_hsa005620.54758616
95Gap junction_Homo sapiens_hsa045400.54582582
96Apoptosis_Homo sapiens_hsa042100.54322950
97Complement and coagulation cascades_Homo sapiens_hsa046100.52500455
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52434710
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52006727
100Fanconi anemia pathway_Homo sapiens_hsa034600.51488672
101Acute myeloid leukemia_Homo sapiens_hsa052210.51371239
102Epstein-Barr virus infection_Homo sapiens_hsa051690.51264837
103Biosynthesis of amino acids_Homo sapiens_hsa012300.50218913
104AMPK signaling pathway_Homo sapiens_hsa041520.50140218
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50126938
106Sphingolipid metabolism_Homo sapiens_hsa006000.49382796
107Toxoplasmosis_Homo sapiens_hsa051450.48171090
108Hepatitis B_Homo sapiens_hsa051610.46367906
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45767494
110ErbB signaling pathway_Homo sapiens_hsa040120.45545748
111FoxO signaling pathway_Homo sapiens_hsa040680.44082787
112Glucagon signaling pathway_Homo sapiens_hsa049220.43816925
113Platelet activation_Homo sapiens_hsa046110.42986890
114GnRH signaling pathway_Homo sapiens_hsa049120.42668166
115Ras signaling pathway_Homo sapiens_hsa040140.42445891
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39572960
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.38913428
118Steroid biosynthesis_Homo sapiens_hsa001000.38648084
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37653483
120Prolactin signaling pathway_Homo sapiens_hsa049170.37093536
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.35246069
122Insulin signaling pathway_Homo sapiens_hsa049100.34955113
123Selenocompound metabolism_Homo sapiens_hsa004500.34824046
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32482314
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32104580
126Dorso-ventral axis formation_Homo sapiens_hsa043200.32028020
127Insulin resistance_Homo sapiens_hsa049310.31975049
128RNA polymerase_Homo sapiens_hsa030200.31374001
129N-Glycan biosynthesis_Homo sapiens_hsa005100.30165038
130Basal transcription factors_Homo sapiens_hsa030220.28853550
131MAPK signaling pathway_Homo sapiens_hsa040100.28448077

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