PTMA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.32391784
2DNA unwinding involved in DNA replication (GO:0006268)5.83756440
3ATP synthesis coupled proton transport (GO:0015986)5.30455608
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30455608
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.26084682
6DNA strand elongation involved in DNA replication (GO:0006271)4.89685154
7ribosomal small subunit assembly (GO:0000028)4.79895838
8protein localization to kinetochore (GO:0034501)4.73404882
9DNA strand elongation (GO:0022616)4.65120341
10DNA replication initiation (GO:0006270)4.62985739
11viral transcription (GO:0019083)4.59127949
12chaperone-mediated protein transport (GO:0072321)4.55555714
13translational termination (GO:0006415)4.49239381
14telomere maintenance via semi-conservative replication (GO:0032201)4.40715146
15maturation of SSU-rRNA (GO:0030490)4.29624564
16ribosomal small subunit biogenesis (GO:0042274)4.20341339
17translation (GO:0006412)4.03383484
18protein localization to chromosome, centromeric region (GO:0071459)4.02363835
19translational elongation (GO:0006414)4.01975302
20mitotic recombination (GO:0006312)3.99015341
21telomere maintenance via recombination (GO:0000722)3.94533854
22DNA replication-dependent nucleosome assembly (GO:0006335)3.91400977
23DNA replication-dependent nucleosome organization (GO:0034723)3.91400977
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.89267707
25translational initiation (GO:0006413)3.85880454
26DNA damage response, detection of DNA damage (GO:0042769)3.85644577
27regulation of mitochondrial translation (GO:0070129)3.85169398
28respiratory electron transport chain (GO:0022904)3.81599437
29ribosomal large subunit biogenesis (GO:0042273)3.80511503
30DNA replication checkpoint (GO:0000076)3.77737855
31formation of translation preinitiation complex (GO:0001731)3.75716813
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75523947
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.72975201
34electron transport chain (GO:0022900)3.72749318
35mitotic chromosome condensation (GO:0007076)3.71757738
36protein targeting to membrane (GO:0006612)3.70517784
37kinetochore organization (GO:0051383)3.68775863
38establishment of viral latency (GO:0019043)3.68434323
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68008024
40proteasome assembly (GO:0043248)3.67919069
41nuclear pore organization (GO:0006999)3.66178057
42CENP-A containing nucleosome assembly (GO:0034080)3.65934309
43mitotic nuclear envelope disassembly (GO:0007077)3.65854448
44mitotic metaphase plate congression (GO:0007080)3.65622562
45cotranslational protein targeting to membrane (GO:0006613)3.65142215
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64347059
47chromatin remodeling at centromere (GO:0031055)3.64141089
48protein targeting to ER (GO:0045047)3.64126990
49negative regulation of RNA splicing (GO:0033119)3.62118226
50DNA replication-independent nucleosome organization (GO:0034724)3.58321717
51DNA replication-independent nucleosome assembly (GO:0006336)3.58321717
52cellular protein complex disassembly (GO:0043624)3.57854490
53nucleobase biosynthetic process (GO:0046112)3.56270299
54sister chromatid segregation (GO:0000819)3.56266469
55establishment of integrated proviral latency (GO:0075713)3.55781374
56telomere maintenance via telomere lengthening (GO:0010833)3.55767560
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.54967053
58DNA duplex unwinding (GO:0032508)3.53725666
59mitotic sister chromatid segregation (GO:0000070)3.51734559
60DNA geometric change (GO:0032392)3.51656749
61viral life cycle (GO:0019058)3.50108300
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48685653
63nuclear pore complex assembly (GO:0051292)3.48564710
64termination of RNA polymerase III transcription (GO:0006386)3.47576363
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.47576363
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47336847
67DNA topological change (GO:0006265)3.44248780
68pseudouridine synthesis (GO:0001522)3.43375553
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41275671
70protein complex disassembly (GO:0043241)3.40500136
71IMP biosynthetic process (GO:0006188)3.39549465
72cellular component biogenesis (GO:0044085)3.39513130
73nuclear envelope disassembly (GO:0051081)3.38965344
74membrane disassembly (GO:0030397)3.38965344
75folic acid-containing compound biosynthetic process (GO:0009396)3.38214719
76protein localization to endoplasmic reticulum (GO:0070972)3.36799196
77ribonucleoprotein complex biogenesis (GO:0022613)3.35559949
78regulation of histone H3-K9 methylation (GO:0051570)3.34345334
79negative regulation of mRNA processing (GO:0050686)3.32398354
80ribosome assembly (GO:0042255)3.32020519
81metaphase plate congression (GO:0051310)3.28939762
82RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.27199693
83mRNA splicing, via spliceosome (GO:0000398)3.27199693
84RNA splicing, via transesterification reactions (GO:0000375)3.26302645
85positive regulation of chromosome segregation (GO:0051984)3.26007446
86rRNA modification (GO:0000154)3.25242316
87mitotic sister chromatid cohesion (GO:0007064)3.22707345
88mitochondrial respiratory chain complex assembly (GO:0033108)3.22020319
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19759523
90chromatin assembly or disassembly (GO:0006333)3.19106105
91attachment of spindle microtubules to kinetochore (GO:0008608)3.18708568
92inner mitochondrial membrane organization (GO:0007007)3.18584032
93macromolecular complex disassembly (GO:0032984)3.18380833
94protein complex biogenesis (GO:0070271)3.17974432
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17950187
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15370542
97ATP-dependent chromatin remodeling (GO:0043044)3.14879610
98nuclear-transcribed mRNA catabolic process (GO:0000956)3.13240391
99purine nucleobase biosynthetic process (GO:0009113)3.12060682
100histone exchange (GO:0043486)3.12057839
101sequestering of actin monomers (GO:0042989)3.08736287
102regulation of spindle organization (GO:0090224)3.08463680
103translesion synthesis (GO:0019985)3.08297077
104protein localization to chromosome (GO:0034502)3.07706681
105rRNA processing (GO:0006364)3.07590966
106IMP metabolic process (GO:0046040)3.06369282
107kinetochore assembly (GO:0051382)3.05967633
108spliceosomal snRNP assembly (GO:0000387)3.03962801
109establishment of chromosome localization (GO:0051303)3.03163225
110protein neddylation (GO:0045116)3.02088519
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00714527
112mitochondrial respiratory chain complex I assembly (GO:0032981)3.00714527
113NADH dehydrogenase complex assembly (GO:0010257)3.00714527
114termination of RNA polymerase II transcription (GO:0006369)2.99660513
115DNA conformation change (GO:0071103)2.98585254
116mRNA catabolic process (GO:0006402)2.97558644
117rRNA metabolic process (GO:0016072)2.97382443
118dosage compensation (GO:0007549)2.97195257
119RNA catabolic process (GO:0006401)2.94477321
120regulation of chromosome segregation (GO:0051983)2.92917742
121DNA-templated transcription, termination (GO:0006353)2.92705299
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92299434
123ribosome biogenesis (GO:0042254)2.91077965
124regulation of mitotic spindle checkpoint (GO:1903504)2.90754148
125regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90754148
126negative regulation of histone methylation (GO:0031061)2.90431885
127regulation of helicase activity (GO:0051095)2.89911116
128negative regulation of mRNA metabolic process (GO:1903312)2.89843544
129DNA ligation (GO:0006266)2.89431940
130regulation of sister chromatid cohesion (GO:0007063)2.88746038
131V(D)J recombination (GO:0033151)2.88712949
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88085235
133chromatin assembly (GO:0031497)2.87870927
134DNA strand renaturation (GO:0000733)2.87633337
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87425163
136negative regulation of ligase activity (GO:0051352)2.87425163
137histone mRNA metabolic process (GO:0008334)2.87166723
138heterochromatin organization (GO:0070828)2.86740949
139spliceosomal complex assembly (GO:0000245)2.86214838
140spindle checkpoint (GO:0031577)2.86080558
141alternative mRNA splicing, via spliceosome (GO:0000380)2.86058907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.94767580
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.85749967
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.16633887
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10868962
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52411027
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44278610
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01437481
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73212972
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.64187007
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53144416
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53003980
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.46226547
13* XRN2_22483619_ChIP-Seq_HELA_Human2.39564985
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.35155447
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.28160611
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27034707
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26726021
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26415037
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23793402
20AR_21909140_ChIP-Seq_LNCAP_Human2.20164788
21* E2F1_21310950_ChIP-Seq_MCF-7_Human2.13994628
22* MYC_22102868_ChIP-Seq_BL_Human2.12531668
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07618692
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05663309
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02036678
26* VDR_23849224_ChIP-Seq_CD4+_Human2.01951627
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94066191
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93697015
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.83896171
30TTF2_22483619_ChIP-Seq_HELA_Human1.82867321
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82425360
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79550762
33* CIITA_25753668_ChIP-Seq_RAJI_Human1.74308628
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73949850
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73284492
36DCP1A_22483619_ChIP-Seq_HELA_Human1.72661146
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69397444
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68353606
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63689117
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.63042796
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62325840
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.61385615
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56955470
44* GABP_19822575_ChIP-Seq_HepG2_Human1.55271506
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54469419
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53923202
47ELK1_19687146_ChIP-ChIP_HELA_Human1.53525450
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51787444
49* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49991132
50KDM5A_27292631_Chip-Seq_BREAST_Human1.49721776
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47919884
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44620791
53* VDR_21846776_ChIP-Seq_THP-1_Human1.43829573
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43180627
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41517580
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40624614
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39722292
58* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39470175
59* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36829964
60* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34223509
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31774267
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.30753662
63* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30003448
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29689607
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28090186
66* EWS_26573619_Chip-Seq_HEK293_Human1.25402463
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20425661
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20154105
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19013711
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18194417
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17372875
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16843371
73* YY1_21170310_ChIP-Seq_MESCs_Mouse1.15634427
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15273225
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14434889
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10957421
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10675220
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10641412
79* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09842619
80* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07234552
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05701754
82* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04541006
83* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02334895
84TFEB_21752829_ChIP-Seq_HELA_Human1.02162424
85* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99594265
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98585346
87NANOG_21062744_ChIP-ChIP_HESCs_Human0.96206027
88* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96165266
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94348998
90* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93795601
91MYC_18940864_ChIP-ChIP_HL60_Human0.92986156
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90101288
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88850003
94SPI1_23547873_ChIP-Seq_NB4_Human0.88594135
95* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88263431
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.86016044
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84344193
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84303004
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84099405
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.82895831
101* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82362413
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82276928
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82276928
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82276928
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82117383
106* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81875099
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81586488
108* UTX_26944678_Chip-Seq_JUKART_Human0.80710567
109* FUS_26573619_Chip-Seq_HEK293_Human0.79916602
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.79386371
111CHD1_26751641_Chip-Seq_LNCaP_Human0.79154205
112* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78646849
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.78135256
114* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77938255
115* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75969495
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73968797
117VDR_22108803_ChIP-Seq_LS180_Human0.71144712
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69525374
119* SOX17_20123909_ChIP-Seq_XEN_Mouse0.68874679
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.68777709
121HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.68327813
122POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.61270716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86470061
2MP0010094_abnormal_chromosome_stability4.47583872
3MP0006292_abnormal_olfactory_placode4.45569752
4MP0003111_abnormal_nucleus_morphology4.06875085
5MP0004957_abnormal_blastocyst_morpholog4.04748775
6MP0003077_abnormal_cell_cycle3.68245496
7MP0008057_abnormal_DNA_replication3.58224186
8MP0008058_abnormal_DNA_repair2.79117677
9MP0008007_abnormal_cellular_replicative2.63631186
10MP0000566_synostosis2.59237169
11MP0008932_abnormal_embryonic_tissue2.50426080
12MP0002396_abnormal_hematopoietic_system2.43366732
13MP0003123_paternal_imprinting2.37250503
14MP0001730_embryonic_growth_arrest2.33971375
15MP0010352_gastrointestinal_tract_polyps2.29986379
16MP0000350_abnormal_cell_proliferation2.24873350
17MP0002277_abnormal_respiratory_mucosa1.94941667
18MP0000490_abnormal_crypts_of1.82384610
19MP0000537_abnormal_urethra_morphology1.82187570
20MP0010307_abnormal_tumor_latency1.74839863
21MP0001697_abnormal_embryo_size1.71790106
22MP0005380_embryogenesis_phenotype1.69671389
23MP0001672_abnormal_embryogenesis/_devel1.69671389
24MP0002085_abnormal_embryonic_tissue1.66689935
25MP0008877_abnormal_DNA_methylation1.65722119
26MP0001188_hyperpigmentation1.62736224
27MP0004808_abnormal_hematopoietic_stem1.60373521
28MP0010030_abnormal_orbit_morphology1.60138905
29MP0001529_abnormal_vocalization1.57982894
30MP0002080_prenatal_lethality1.57564341
31MP0002084_abnormal_developmental_patter1.56915313
32MP0009053_abnormal_anal_canal1.54585688
33MP0003786_premature_aging1.53333635
34MP0005076_abnormal_cell_differentiation1.51506550
35MP0003984_embryonic_growth_retardation1.51201236
36MP0003121_genomic_imprinting1.51014112
37MP0004197_abnormal_fetal_growth/weight/1.49533391
38MP0002088_abnormal_embryonic_growth/wei1.48643243
39MP0003567_abnormal_fetal_cardiomyocyte1.47860307
40MP0008995_early_reproductive_senescence1.46980289
41MP0005084_abnormal_gallbladder_morpholo1.43847740
42MP0006072_abnormal_retinal_apoptosis1.43475633
43MP0001485_abnormal_pinna_reflex1.42754401
44MP0001293_anophthalmia1.37851027
45MP0002019_abnormal_tumor_incidence1.37653857
46MP0000313_abnormal_cell_death1.37210095
47MP0002086_abnormal_extraembryonic_tissu1.37040893
48MP0006054_spinal_hemorrhage1.36288221
49MP0003315_abnormal_perineum_morphology1.34794909
50MP0000631_abnormal_neuroendocrine_gland1.32530051
51MP0009697_abnormal_copulation1.31759183
52MP0000703_abnormal_thymus_morphology1.30525325
53MP0003763_abnormal_thymus_physiology1.28078930
54MP0009278_abnormal_bone_marrow1.23515352
55MP0009333_abnormal_splenocyte_physiolog1.23466360
56MP0004742_abnormal_vestibular_system1.22595214
57MP0003878_abnormal_ear_physiology1.16806759
58MP0005377_hearing/vestibular/ear_phenot1.16806759
59MP0003937_abnormal_limbs/digits/tail_de1.13097442
60MP0008789_abnormal_olfactory_epithelium1.12039229
61MP0003283_abnormal_digestive_organ1.10988617
62MP0003890_abnormal_embryonic-extraembry1.09911701
63MP0005397_hematopoietic_system_phenotyp1.09679722
64MP0001545_abnormal_hematopoietic_system1.09679722
65MP0002398_abnormal_bone_marrow1.08372200
66MP0001346_abnormal_lacrimal_gland1.06840584
67MP0001849_ear_inflammation1.04715890
68MP0003119_abnormal_digestive_system1.01335676
69MP0002722_abnormal_immune_system1.00301082
70MP0002234_abnormal_pharynx_morphology1.00143104
71MP0002102_abnormal_ear_morphology0.98366191
72MP0002736_abnormal_nociception_after0.97626535
73MP0002210_abnormal_sex_determination0.96936051
74MP0003186_abnormal_redox_activity0.96185402
75MP0002938_white_spotting0.95591467
76MP0002233_abnormal_nose_morphology0.95429470
77MP0009379_abnormal_foot_pigmentation0.95187505
78MP0002111_abnormal_tail_morphology0.94707686
79MP0002092_abnormal_eye_morphology0.94088590
80MP0006035_abnormal_mitochondrial_morpho0.93109061
81MP0009672_abnormal_birth_weight0.93024453
82MP0000372_irregular_coat_pigmentation0.92500615
83MP0000428_abnormal_craniofacial_morphol0.91981150
84MP0002160_abnormal_reproductive_system0.89455055
85MP0001145_abnormal_male_reproductive0.88695385
86MP0001286_abnormal_eye_development0.88328967
87MP0000689_abnormal_spleen_morphology0.88217071
88MP0003941_abnormal_skin_development0.86017061
89MP0009703_decreased_birth_body0.85355127
90MP0000579_abnormal_nail_morphology0.84979134
91MP0000465_gastrointestinal_hemorrhage0.84330164
92MP0002429_abnormal_blood_cell0.79951820
93MP0000858_altered_metastatic_potential0.79800954
94MP0005645_abnormal_hypothalamus_physiol0.79731382
95MP0000477_abnormal_intestine_morphology0.76857671
96MP0003718_maternal_effect0.76413471
97MP0004133_heterotaxia0.75397540
98MP0000049_abnormal_middle_ear0.74271689
99MP0000733_abnormal_muscle_development0.74252186
100MP0002249_abnormal_larynx_morphology0.74194406
101MP0001915_intracranial_hemorrhage0.73252851
102MP0005391_vision/eye_phenotype0.72263463
103MP0003136_yellow_coat_color0.71693360
104MP0003705_abnormal_hypodermis_morpholog0.71571223
105MP0002095_abnormal_skin_pigmentation0.71149625
106MP0009250_abnormal_appendicular_skeleto0.70833209
107MP0000653_abnormal_sex_gland0.70424467
108MP0001919_abnormal_reproductive_system0.70074907
109MP0002796_impaired_skin_barrier0.69871141
110MP0003861_abnormal_nervous_system0.69854487
111MP0000716_abnormal_immune_system0.69592390
112MP0005501_abnormal_skin_physiology0.69007497
113MP0000383_abnormal_hair_follicle0.68535308
114MP0005389_reproductive_system_phenotype0.67966223
115MP0003806_abnormal_nucleotide_metabolis0.67149338
116MP0000432_abnormal_head_morphology0.67027394
117MP0002697_abnormal_eye_size0.66545448
118MP0003935_abnormal_craniofacial_develop0.65234537
119MP0002132_abnormal_respiratory_system0.64529351
120MP0000377_abnormal_hair_follicle0.64087524
121MP0003011_delayed_dark_adaptation0.63944681
122MP0003787_abnormal_imprinting0.63712010
123MP0002932_abnormal_joint_morphology0.63527631
124MP0003938_abnormal_ear_development0.63387998
125MP0005384_cellular_phenotype0.63061135
126MP0002653_abnormal_ependyma_morphology0.62966077
127MP0000762_abnormal_tongue_morphology0.62607078
128MP0001929_abnormal_gametogenesis0.62513743
129MP0005174_abnormal_tail_pigmentation0.62231219
130MP0005499_abnormal_olfactory_system0.61849977
131MP0005394_taste/olfaction_phenotype0.61849977
132MP0006036_abnormal_mitochondrial_physio0.61380440
133MP0005187_abnormal_penis_morphology0.61280002
134MP0003566_abnormal_cell_adhesion0.61113616
135MP0003698_abnormal_male_reproductive0.60972313
136MP0002282_abnormal_trachea_morphology0.60807715
137MP0002751_abnormal_autonomic_nervous0.60317093
138MP0000026_abnormal_inner_ear0.59982219
139MP0001119_abnormal_female_reproductive0.59585265

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.58992458
2Increased hepatocellular lipid droplets (HP:0006565)4.31848250
3Abnormality of cells of the erythroid lineage (HP:0012130)4.16407116
4Septo-optic dysplasia (HP:0100842)4.09533576
5Acute necrotizing encephalopathy (HP:0006965)3.97827439
6Abnormal number of erythroid precursors (HP:0012131)3.82027373
7Lipid accumulation in hepatocytes (HP:0006561)3.81644564
8Colon cancer (HP:0003003)3.69165363
9Birth length less than 3rd percentile (HP:0003561)3.65139689
10Mitochondrial inheritance (HP:0001427)3.59479731
11Abnormal mitochondria in muscle tissue (HP:0008316)3.54602873
12Acute encephalopathy (HP:0006846)3.50178864
13Selective tooth agenesis (HP:0001592)3.26941399
14Patellar aplasia (HP:0006443)3.12383931
15Increased CSF lactate (HP:0002490)3.12291421
16Progressive macrocephaly (HP:0004481)3.11184654
17Renal Fanconi syndrome (HP:0001994)3.04542054
18Medulloblastoma (HP:0002885)3.04486970
19Ependymoma (HP:0002888)3.02518832
20Aplasia/Hypoplasia of the patella (HP:0006498)3.00053802
21Chromsome breakage (HP:0040012)2.95529899
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94377050
23Macrocytic anemia (HP:0001972)2.93510613
24Breast hypoplasia (HP:0003187)2.93344125
25Oral leukoplakia (HP:0002745)2.90288125
26Respiratory difficulties (HP:0002880)2.86634091
27Congenital, generalized hypertrichosis (HP:0004540)2.80235790
28Maternal diabetes (HP:0009800)2.76517439
29Hepatocellular necrosis (HP:0001404)2.76296955
30Abnormality of chromosome stability (HP:0003220)2.75989341
31Abnormal number of incisors (HP:0011064)2.74373440
32Increased nuchal translucency (HP:0010880)2.70898237
33Atresia of the external auditory canal (HP:0000413)2.69656071
34Absent septum pellucidum (HP:0001331)2.68164439
35Cerebral edema (HP:0002181)2.67968218
36Pallor (HP:0000980)2.67073280
37Proximal placement of thumb (HP:0009623)2.66745997
38Increased intramyocellular lipid droplets (HP:0012240)2.63833261
39Meckel diverticulum (HP:0002245)2.61506704
40Bilateral microphthalmos (HP:0007633)2.60685450
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60017837
42Absent thumb (HP:0009777)2.57377081
43Abnormality of the preputium (HP:0100587)2.54313979
44Aplastic anemia (HP:0001915)2.54278367
45Abnormality of the septum pellucidum (HP:0007375)2.52141555
4611 pairs of ribs (HP:0000878)2.50509346
47Deviation of the thumb (HP:0009603)2.50459274
48Exertional dyspnea (HP:0002875)2.49931105
49Abnormality of the ileum (HP:0001549)2.48720567
50Neoplasm of the pancreas (HP:0002894)2.46278788
51Degeneration of anterior horn cells (HP:0002398)2.44510383
52Abnormality of the anterior horn cell (HP:0006802)2.44510383
53Volvulus (HP:0002580)2.44173656
54Pendular nystagmus (HP:0012043)2.42897117
55Short 4th metacarpal (HP:0010044)2.40537568
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40537568
57Myelodysplasia (HP:0002863)2.38692361
58Duodenal stenosis (HP:0100867)2.34373927
59Small intestinal stenosis (HP:0012848)2.34373927
60Microvesicular hepatic steatosis (HP:0001414)2.33967518
61Basal cell carcinoma (HP:0002671)2.33614285
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.33244302
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33137502
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33137502
65Partial duplication of thumb phalanx (HP:0009944)2.32552276
66Rhabdomyosarcoma (HP:0002859)2.32300577
67Rough bone trabeculation (HP:0100670)2.31994959
68Absent radius (HP:0003974)2.31899565
69Abnormal lung lobation (HP:0002101)2.31475986
70Hepatic necrosis (HP:0002605)2.31412293
71Agnosia (HP:0010524)2.28236902
72Thrombocytosis (HP:0001894)2.27923630
73Ectopic kidney (HP:0000086)2.25910401
74Impulsivity (HP:0100710)2.19338512
75Acute lymphatic leukemia (HP:0006721)2.19326070
76Partial duplication of the phalanx of hand (HP:0009999)2.19146284
77Carpal bone hypoplasia (HP:0001498)2.18965179
78Pancytopenia (HP:0001876)2.16613391
79Trismus (HP:0000211)2.15408470
80Nasolacrimal duct obstruction (HP:0000579)2.15076523
81Aplasia involving forearm bones (HP:0009822)2.14545374
82Absent forearm bone (HP:0003953)2.14545374
83Abnormality of the lacrimal duct (HP:0011481)2.14237617
84Missing ribs (HP:0000921)2.12202704
85Leukodystrophy (HP:0002415)2.12097402
863-Methylglutaconic aciduria (HP:0003535)2.11821849
87Tracheoesophageal fistula (HP:0002575)2.10452906
88Bone marrow hypocellularity (HP:0005528)2.08089054
89Increased muscle lipid content (HP:0009058)2.06720717
90Premature graying of hair (HP:0002216)2.05958787
91Abnormality of the labia minora (HP:0012880)2.03907511
92Overlapping toe (HP:0001845)2.02798365
93Duplication of thumb phalanx (HP:0009942)2.01168359
94Glossoptosis (HP:0000162)2.00894003
95Rib fusion (HP:0000902)1.98609322
96Cellular immunodeficiency (HP:0005374)1.98301580
97Supernumerary spleens (HP:0009799)1.97533595
98Increased serum lactate (HP:0002151)1.96830014
99Asplenia (HP:0001746)1.95792491
100Optic disc pallor (HP:0000543)1.94937043
101Amaurosis fugax (HP:0100576)1.94429662
102Triphalangeal thumb (HP:0001199)1.94070948
103Sloping forehead (HP:0000340)1.93899414
104Esophageal atresia (HP:0002032)1.93581973
105Abnormality of the duodenum (HP:0002246)1.92049929
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90940699
107Neoplasm of the oral cavity (HP:0100649)1.90901664
108Hypoplasia of the pons (HP:0012110)1.90691554
109Lactic acidosis (HP:0003128)1.90307778
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90217265
111Abnormality of the nasolacrimal system (HP:0000614)1.89860880
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.89413048
113Exercise intolerance (HP:0003546)1.89349303
114Lymphoma (HP:0002665)1.88552047
115Short thumb (HP:0009778)1.88454691
116Cerebral hypomyelination (HP:0006808)1.88171120
117High pitched voice (HP:0001620)1.87412145
118IgM deficiency (HP:0002850)1.86568674
119Microretrognathia (HP:0000308)1.86421882
120Squamous cell carcinoma (HP:0002860)1.86216767
121Abnormality of the carotid arteries (HP:0005344)1.85392472
122Renal duplication (HP:0000075)1.84825491
123Horseshoe kidney (HP:0000085)1.84737558
124Abnormality of the pons (HP:0007361)1.83908789
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83442595
126Abnormality of the calcaneus (HP:0008364)1.83007684
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.82826736
128Neoplasm of striated muscle (HP:0009728)1.82021716
129Short middle phalanx of the 5th finger (HP:0004220)1.81996372
130Hypoplasia of the radius (HP:0002984)1.81746936
131Abnormality of renal resorption (HP:0011038)1.81544732
132Abnormality of the astrocytes (HP:0100707)1.81306537
133Astrocytoma (HP:0009592)1.81306537
134Megaloblastic anemia (HP:0001889)1.79365808
135Cafe-au-lait spot (HP:0000957)1.77363251
136Neoplasm of the colon (HP:0100273)1.77137931
137Abnormality of the 4th metacarpal (HP:0010012)1.77019418
138Abnormality of the parietal bone (HP:0002696)1.76962308
139Biliary tract neoplasm (HP:0100574)1.76338904
140Multiple enchondromatosis (HP:0005701)1.76320357
141Gastrointestinal atresia (HP:0002589)1.76145960
142Optic nerve hypoplasia (HP:0000609)1.75916983
143Depressed nasal ridge (HP:0000457)1.75720401
144Clubbing of toes (HP:0100760)1.74769804
145Ovarian neoplasm (HP:0100615)1.74745875
146Anophthalmia (HP:0000528)1.74095947
147Respiratory failure (HP:0002878)1.74094365
148Preauricular skin tag (HP:0000384)1.73176033
149Sparse eyelashes (HP:0000653)1.72041010
150Gastrointestinal carcinoma (HP:0002672)1.71455457
151Malignant gastrointestinal tract tumors (HP:0006749)1.71455457
152Abnormal umbilical cord blood vessels (HP:0011403)1.70891187
153Single umbilical artery (HP:0001195)1.70891187
154Abnormality of the fetal cardiovascular system (HP:0010948)1.70891187
155Cleft eyelid (HP:0000625)1.70538845
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69400968
157Dysphonia (HP:0001618)1.65493064
158Hyperglycinuria (HP:0003108)1.62698078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.58193444
2CDC74.46624392
3BUB14.06279133
4WEE13.88774104
5NEK22.84963763
6TAF12.84292141
7EEF2K2.79453451
8TSSK62.62987688
9SRPK12.54415600
10MKNK12.42090168
11MAP3K102.40428175
12PASK2.25204392
13RPS6KB22.22218992
14TESK22.11657397
15TTK2.07393752
16NME12.06914025
17EIF2AK12.06357163
18TNIK2.06151969
19DYRK32.03263254
20NUAK11.87671094
21VRK11.81213640
22TLK11.79211409
23NME21.69604806
24MKNK21.68923188
25PLK11.67537533
26NEK11.67191945
27AURKB1.67085622
28ATR1.63343640
29CLK11.61552372
30CDK121.59641048
31CDK71.58314928
32STK101.55361892
33PLK41.50560380
34ACVR1B1.49978984
35PLK31.48081867
36CDK41.47673317
37TGFBR11.47529452
38EIF2AK31.45968702
39MAP3K81.45221499
40BRSK21.43232955
41RPS6KA41.38944880
42STK41.30742238
43CHEK21.23504410
44CHEK11.23159451
45PAK41.22656600
46LRRK21.22147910
47PKN21.18732519
48STK161.16860722
49AURKA1.12042583
50WNK31.08521164
51CDK61.06029019
52MAP4K11.00922223
53SCYL21.00274413
54ALK1.00260432
55PIM10.94895968
56BRD40.92265546
57BRSK10.90567666
58EPHA20.90493261
59CDK20.89883196
60PNCK0.88812256
61ATM0.88546300
62CCNB10.79681500
63TESK10.75088625
64LATS20.74010660
65CDK190.73659526
66MELK0.71987542
67CDK30.71832508
68GRK60.71692492
69BTK0.70254011
70CDK10.68939171
71* CSNK2A20.68797263
72RPS6KA50.66812254
73PAK10.66308466
74PIM20.65115101
75MST40.63747603
76KIT0.60977858
77* CSNK2A10.57983865
78FLT30.54179099
79INSRR0.53708583
80BCKDK0.52934428
81MAPK150.50828236
82STK30.50228980
83NLK0.49994621
84ILK0.49913241
85BMPR1B0.49228409
86MAPKAPK30.48826667
87CDK80.48295859
88PAK20.46372721
89SMG10.46360012
90LIMK10.46204916
91AKT20.45680326
92MTOR0.44049172
93TRIB30.44006485
94CSNK1E0.43969768
95ZAK0.43751152
96DYRK1B0.42461454
97PBK0.42213058
98WNK40.42062679
99TRIM280.39799382
100PRKCI0.39158993
101PRKDC0.37815607
102MAPKAPK50.37680553
103CSNK1G30.37488049
104CDK90.36872849
105CSNK1D0.36767549
106PTK60.35799823
107UHMK10.33981924
108KDR0.33073454
109DYRK20.32601485
110MAP2K70.31981164
111EPHB20.31580444
112PRKCG0.31314558
113EIF2AK20.30182167
114STK240.30037675
115MAPKAPK20.29970623
116MAPK140.29777439
117RPS6KC10.28552721
118RPS6KL10.28552721
119BLK0.28450212
120TEC0.28230930
121FGFR10.27916742
122RPS6KA10.27591362
123MAP2K20.26755796
124CSNK1A1L0.26614573
125CDK11A0.22327329
126OXSR10.20144149
127DMPK0.19145777
128PRKACB0.17809503
129GSK3B0.17791126
130STK390.17565199
131AKT10.17048696
132CSNK1A10.16766149

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08630064
2Mismatch repair_Homo sapiens_hsa034304.22553268
3Ribosome_Homo sapiens_hsa030103.81427590
4Spliceosome_Homo sapiens_hsa030403.72360333
5Oxidative phosphorylation_Homo sapiens_hsa001903.65455057
6Parkinsons disease_Homo sapiens_hsa050123.32191477
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16638195
8Base excision repair_Homo sapiens_hsa034103.09400249
9RNA transport_Homo sapiens_hsa030133.01965993
10Homologous recombination_Homo sapiens_hsa034402.90340749
11Cell cycle_Homo sapiens_hsa041102.88738437
12Nucleotide excision repair_Homo sapiens_hsa034202.76527035
13RNA polymerase_Homo sapiens_hsa030202.62383786
14One carbon pool by folate_Homo sapiens_hsa006702.48131542
15Proteasome_Homo sapiens_hsa030502.45679145
16Non-homologous end-joining_Homo sapiens_hsa034502.39052912
17Fanconi anemia pathway_Homo sapiens_hsa034602.14214200
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13113826
19Pyrimidine metabolism_Homo sapiens_hsa002402.11979731
20Alzheimers disease_Homo sapiens_hsa050102.11807488
21mRNA surveillance pathway_Homo sapiens_hsa030152.02043600
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89604662
23RNA degradation_Homo sapiens_hsa030181.76963609
24Systemic lupus erythematosus_Homo sapiens_hsa053221.74191993
25Cardiac muscle contraction_Homo sapiens_hsa042601.62405011
26Basal transcription factors_Homo sapiens_hsa030221.58869557
27p53 signaling pathway_Homo sapiens_hsa041151.53957827
28Viral carcinogenesis_Homo sapiens_hsa052031.25808436
29* Epstein-Barr virus infection_Homo sapiens_hsa051691.18506873
30Antigen processing and presentation_Homo sapiens_hsa046121.09389681
31Purine metabolism_Homo sapiens_hsa002301.04186325
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03543571
33Herpes simplex infection_Homo sapiens_hsa051680.99010929
34HTLV-I infection_Homo sapiens_hsa051660.96700857
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95350790
36MicroRNAs in cancer_Homo sapiens_hsa052060.94300924
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94148012
38Primary immunodeficiency_Homo sapiens_hsa053400.92151300
39Oocyte meiosis_Homo sapiens_hsa041140.89973891
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88210288
41Alcoholism_Homo sapiens_hsa050340.87395159
42Thyroid cancer_Homo sapiens_hsa052160.85869340
43Small cell lung cancer_Homo sapiens_hsa052220.85015779
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81885802
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80573041
46Chronic myeloid leukemia_Homo sapiens_hsa052200.77832062
47Basal cell carcinoma_Homo sapiens_hsa052170.76747886
48Pyruvate metabolism_Homo sapiens_hsa006200.76188025
49Colorectal cancer_Homo sapiens_hsa052100.75995831
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.75536160
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70817796
52Pentose phosphate pathway_Homo sapiens_hsa000300.69606181
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68172100
54Hippo signaling pathway_Homo sapiens_hsa043900.62910757
55Protein export_Homo sapiens_hsa030600.61608579
56Notch signaling pathway_Homo sapiens_hsa043300.61400062
57Apoptosis_Homo sapiens_hsa042100.59010986
58Vitamin digestion and absorption_Homo sapiens_hsa049770.58811966
59TGF-beta signaling pathway_Homo sapiens_hsa043500.58589999
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58178591
61Selenocompound metabolism_Homo sapiens_hsa004500.55131875
62Hepatitis B_Homo sapiens_hsa051610.54917210
63Legionellosis_Homo sapiens_hsa051340.53659947
64Metabolic pathways_Homo sapiens_hsa011000.53101599
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52835808
66Phototransduction_Homo sapiens_hsa047440.51796114
67Prostate cancer_Homo sapiens_hsa052150.48817852
68Pathways in cancer_Homo sapiens_hsa052000.47624084
69Shigellosis_Homo sapiens_hsa051310.47035055
70Measles_Homo sapiens_hsa051620.44846797
71Hedgehog signaling pathway_Homo sapiens_hsa043400.44798419
72Acute myeloid leukemia_Homo sapiens_hsa052210.44472968
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.44182005
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43107214
75Folate biosynthesis_Homo sapiens_hsa007900.42682779
76N-Glycan biosynthesis_Homo sapiens_hsa005100.42242068
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.42194347
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42044353
79Non-small cell lung cancer_Homo sapiens_hsa052230.41976691
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.41964313
81Biosynthesis of amino acids_Homo sapiens_hsa012300.41962927
82Bladder cancer_Homo sapiens_hsa052190.41374931
83Viral myocarditis_Homo sapiens_hsa054160.40961622
84Propanoate metabolism_Homo sapiens_hsa006400.40211294
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39231923
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.38809050
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.37952783
88Sulfur relay system_Homo sapiens_hsa041220.37286035
89B cell receptor signaling pathway_Homo sapiens_hsa046620.36732242
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35184021
91Adherens junction_Homo sapiens_hsa045200.34433944
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33487667
93Glutathione metabolism_Homo sapiens_hsa004800.33441620
94Pancreatic cancer_Homo sapiens_hsa052120.32074421
95Wnt signaling pathway_Homo sapiens_hsa043100.31686249
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29938561
97Hematopoietic cell lineage_Homo sapiens_hsa046400.29915760
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29491754
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28075710
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.27122913
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27110880
102Endometrial cancer_Homo sapiens_hsa052130.26716063
103Tight junction_Homo sapiens_hsa045300.26328472
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26185652
105Proteoglycans in cancer_Homo sapiens_hsa052050.25686111
106T cell receptor signaling pathway_Homo sapiens_hsa046600.25301531
107HIF-1 signaling pathway_Homo sapiens_hsa040660.24934052
108Nicotine addiction_Homo sapiens_hsa050330.24259662
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23699812
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23697673
111Influenza A_Homo sapiens_hsa051640.23495540
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.22859479
113Tyrosine metabolism_Homo sapiens_hsa003500.22846112
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22565959
115Caffeine metabolism_Homo sapiens_hsa002320.22525540
116mTOR signaling pathway_Homo sapiens_hsa041500.21740853
117Lysine degradation_Homo sapiens_hsa003100.21317665
118Olfactory transduction_Homo sapiens_hsa047400.21048789
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20151407
120Carbon metabolism_Homo sapiens_hsa012000.19712784
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19487356
122Melanoma_Homo sapiens_hsa052180.19346277
123Steroid biosynthesis_Homo sapiens_hsa001000.19341252
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19212120
125Vitamin B6 metabolism_Homo sapiens_hsa007500.18854110
126Leishmaniasis_Homo sapiens_hsa051400.16808357
127Taste transduction_Homo sapiens_hsa047420.16547819
128FoxO signaling pathway_Homo sapiens_hsa040680.15883116
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15298520
130Nitrogen metabolism_Homo sapiens_hsa009100.14501396
131Huntingtons disease_Homo sapiens_hsa050160.14457931
132Toxoplasmosis_Homo sapiens_hsa051450.13852220
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13653149
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10755560
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10753699
136Retinol metabolism_Homo sapiens_hsa008300.10521231
137beta-Alanine metabolism_Homo sapiens_hsa004100.09752839
138Linoleic acid metabolism_Homo sapiens_hsa005910.09509445
139Chemical carcinogenesis_Homo sapiens_hsa052040.08057136
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.06643752
141Asthma_Homo sapiens_hsa053100.06573091
142Arginine and proline metabolism_Homo sapiens_hsa003300.06311479
143Tryptophan metabolism_Homo sapiens_hsa003800.05989334
144Butanoate metabolism_Homo sapiens_hsa006500.05904845
145Fatty acid elongation_Homo sapiens_hsa000620.05264814
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.03938736

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