PTMAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.15902260
2DNA deamination (GO:0045006)5.05502019
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.97883644
4viral transcription (GO:0019083)4.92604606
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.91027174
6ATP synthesis coupled proton transport (GO:0015986)4.91027174
7ribosomal small subunit biogenesis (GO:0042274)4.90541634
8regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.87174281
9maturation of SSU-rRNA (GO:0030490)4.84245837
10translational termination (GO:0006415)4.71999451
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.67785259
12cytidine metabolic process (GO:0046087)4.28521669
13cytidine catabolic process (GO:0006216)4.28521669
14cytidine deamination (GO:0009972)4.28521669
15translational elongation (GO:0006414)4.20605945
16ribosomal small subunit assembly (GO:0000028)4.14910527
17substrate-independent telencephalic tangential migration (GO:0021826)4.00889473
18substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.00889473
19mitochondrial calcium ion transport (GO:0006851)3.96232116
20protein neddylation (GO:0045116)3.82985793
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80394911
22protein targeting to ER (GO:0045047)3.79808827
23cotranslational protein targeting to membrane (GO:0006613)3.76517844
24arachidonic acid secretion (GO:0050482)3.70904859
25icosanoid secretion (GO:0032309)3.70904859
26regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.68611241
27regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.68611241
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67606600
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67606600
30nephron epithelium morphogenesis (GO:0072088)3.66670971
31nephron tubule morphogenesis (GO:0072078)3.66670971
32protein localization to endoplasmic reticulum (GO:0070972)3.65757087
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64112941
34pyrimidine ribonucleoside catabolic process (GO:0046133)3.60229818
35viral life cycle (GO:0019058)3.57036829
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54293521
37protein complex biogenesis (GO:0070271)3.49975544
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.48955768
39cellular protein complex disassembly (GO:0043624)3.47487657
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44355847
41chaperone-mediated protein transport (GO:0072321)3.35605129
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.35427264
43NADH dehydrogenase complex assembly (GO:0010257)3.35427264
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35427264
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.33641257
46synaptic transmission, dopaminergic (GO:0001963)3.33587818
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22730940
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20720740
49electron transport chain (GO:0022900)3.16984560
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14763303
51positive regulation of T cell apoptotic process (GO:0070234)3.14707236
52respiratory electron transport chain (GO:0022904)3.13017766
53regulation of regulatory T cell differentiation (GO:0045589)3.07551159
54mitochondrial respiratory chain complex assembly (GO:0033108)3.05762228
55protein complex disassembly (GO:0043241)3.01346991
56negative regulation of oligodendrocyte differentiation (GO:0048715)2.99061266
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97850635
58transmission of nerve impulse (GO:0019226)2.94843043
59behavioral response to cocaine (GO:0048148)2.94379445
60response to pheromone (GO:0019236)2.93943123
61cell proliferation in forebrain (GO:0021846)2.90419747
62ATP biosynthetic process (GO:0006754)2.90037744
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89665666
64protein-cofactor linkage (GO:0018065)2.88895168
65GTP biosynthetic process (GO:0006183)2.88487417
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86170333
67positive regulation of tolerance induction (GO:0002645)2.85675345
68icosanoid transport (GO:0071715)2.85269133
69fatty acid derivative transport (GO:1901571)2.85269133
70purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85055402
71cellular biogenic amine catabolic process (GO:0042402)2.84981489
72amine catabolic process (GO:0009310)2.84981489
73macromolecular complex disassembly (GO:0032984)2.84030031
74regulation of synaptic transmission, dopaminergic (GO:0032225)2.83223127
75cornea development in camera-type eye (GO:0061303)2.82441580
76positive regulation of protein homooligomerization (GO:0032464)2.81699086
77regulation of neurotransmitter uptake (GO:0051580)2.80520890
78sequestering of actin monomers (GO:0042989)2.80294240
79positive regulation of respiratory burst (GO:0060267)2.79192752
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78560137
81cellular component biogenesis (GO:0044085)2.78280078
82translational initiation (GO:0006413)2.77703214
83protein import into peroxisome matrix (GO:0016558)2.76277764
84negative regulation of mast cell activation (GO:0033004)2.75767820
85intracellular protein transmembrane import (GO:0044743)2.74003412
86water-soluble vitamin biosynthetic process (GO:0042364)2.73389595
87G-protein coupled receptor internalization (GO:0002031)2.72691225
88pattern specification involved in kidney development (GO:0061004)2.72159700
89epithelial cilium movement (GO:0003351)2.71839807
90grooming behavior (GO:0007625)2.70746866
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64848165
92renal tubule morphogenesis (GO:0061333)2.62657712
93translation (GO:0006412)2.61628885
94ribonucleoprotein complex biogenesis (GO:0022613)2.61588820
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60585199
96ubiquinone biosynthetic process (GO:0006744)2.59969328
97regulation of T cell tolerance induction (GO:0002664)2.58202847
98negative regulation of telomere maintenance (GO:0032205)2.55279360
99negative regulation by host of viral transcription (GO:0043922)2.55240980
100protein targeting to membrane (GO:0006612)2.52833890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.26338722
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.67697491
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40076040
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21444322
5ZNF274_21170338_ChIP-Seq_K562_Hela2.97966665
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96582936
7VDR_22108803_ChIP-Seq_LS180_Human2.80689736
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.24646407
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14609995
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.13568204
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.05091886
12BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99737063
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99013736
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.95826691
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.90176506
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.87568080
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81989817
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78561960
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77826758
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76306516
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63699064
22REST_21632747_ChIP-Seq_MESCs_Mouse1.60633729
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60334063
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58784006
25IGF1R_20145208_ChIP-Seq_DFB_Human1.54175517
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53422342
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51885218
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.51227497
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47734927
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.47564376
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45266460
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.44940679
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42364881
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.40073877
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39908671
36TP53_22573176_ChIP-Seq_HFKS_Human1.39131826
37MYC_18940864_ChIP-ChIP_HL60_Human1.38367475
38EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.37614518
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36153777
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.35876816
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33776033
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32977434
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32571941
44NANOG_20526341_ChIP-Seq_ESCs_Human1.31705752
45TAF2_19829295_ChIP-Seq_ESCs_Human1.31325764
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29038300
47BCL6_27268052_Chip-Seq_Bcells_Human1.26921783
48ERA_21632823_ChIP-Seq_H3396_Human1.26077634
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.26075844
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24868059
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24868059
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.24546518
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23579410
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23192294
55P53_21459846_ChIP-Seq_SAOS-2_Human1.22566281
56IRF1_19129219_ChIP-ChIP_H3396_Human1.19849477
57MYC_19829295_ChIP-Seq_ESCs_Human1.18875599
58E2F1_20622854_ChIP-Seq_HELA_Human1.18132744
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17945387
60CTCF_20526341_ChIP-Seq_ESCs_Human1.17827516
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17700370
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16051289
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15873363
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14021176
65NCOR_22424771_ChIP-Seq_293T_Human1.13645008
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13387921
67RNF2_27304074_Chip-Seq_NSC_Mouse1.13037558
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11199977
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10083385
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08862161
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07948192
72CTCF_27219007_Chip-Seq_Bcells_Human1.07886679
73SA1_27219007_Chip-Seq_Bcells_Human1.06507269
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05793682
75HTT_18923047_ChIP-ChIP_STHdh_Human1.05646894
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04840219
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03006917
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.99515517
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99303584
80ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95226605
81FOXH1_21741376_ChIP-Seq_EPCs_Human0.94541435
82FOXH1_21741376_ChIP-Seq_ESCs_Human0.94466599
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94326886
84P300_27268052_Chip-Seq_Bcells_Human0.94056027
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93544997
86DROSHA_22980978_ChIP-Seq_HELA_Human0.93300983
87P68_20966046_ChIP-Seq_HELA_Human0.93122564
88RAC3_21632823_ChIP-Seq_H3396_Human0.92921231
89VDR_23849224_ChIP-Seq_CD4+_Human0.91852955
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91719081
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90630487
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90623375
93IRF8_22096565_ChIP-ChIP_GC-B_Human0.90611442
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90412327
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90222985
96NANOG_19829295_ChIP-Seq_ESCs_Human0.90183962
97SOX2_19829295_ChIP-Seq_ESCs_Human0.90183962
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90175401
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90050688
100GBX2_23144817_ChIP-Seq_PC3_Human0.89549980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.05077872
2MP0003123_paternal_imprinting3.25111007
3MP0002163_abnormal_gland_morphology3.08160048
4MP0006292_abnormal_olfactory_placode3.00068899
5MP0002638_abnormal_pupillary_reflex2.91371893
6MP0004885_abnormal_endolymph2.53640442
7MP0003787_abnormal_imprinting2.42845753
8MP0005671_abnormal_response_to2.32183645
9MP0003646_muscle_fatigue2.31974064
10MP0005646_abnormal_pituitary_gland2.26494803
11MP0005645_abnormal_hypothalamus_physiol2.08906427
12MP0006276_abnormal_autonomic_nervous2.06125078
13MP0009046_muscle_twitch1.97985618
14MP0006072_abnormal_retinal_apoptosis1.94509569
15MP0002138_abnormal_hepatobiliary_system1.89127289
16MP0004742_abnormal_vestibular_system1.84662309
17MP0005377_hearing/vestibular/ear_phenot1.83534564
18MP0003878_abnormal_ear_physiology1.83534564
19MP0002102_abnormal_ear_morphology1.81302289
20MP0001919_abnormal_reproductive_system1.81263500
21MP0008789_abnormal_olfactory_epithelium1.77184397
22MP0008877_abnormal_DNA_methylation1.76199991
23MP0001485_abnormal_pinna_reflex1.73156526
24MP0001440_abnormal_grooming_behavior1.69531680
25MP0002160_abnormal_reproductive_system1.68261655
26MP0008872_abnormal_physiological_respon1.68228668
27MP0004142_abnormal_muscle_tone1.67104077
28MP0005551_abnormal_eye_electrophysiolog1.60257964
29MP0002272_abnormal_nervous_system1.57059632
30MP0005379_endocrine/exocrine_gland_phen1.56235974
31MP0003011_delayed_dark_adaptation1.54918343
32MP0003880_abnormal_central_pattern1.54408335
33MP0004145_abnormal_muscle_electrophysio1.54142947
34MP0005389_reproductive_system_phenotype1.53204086
35MP0003121_genomic_imprinting1.53027614
36MP0003938_abnormal_ear_development1.52771007
37MP0000049_abnormal_middle_ear1.50760682
38MP0005083_abnormal_biliary_tract1.49614886
39MP0005499_abnormal_olfactory_system1.47345155
40MP0005394_taste/olfaction_phenotype1.47345155
41MP0004133_heterotaxia1.47246280
42MP0000372_irregular_coat_pigmentation1.44835979
43MP0008875_abnormal_xenobiotic_pharmacok1.40684070
44MP0001348_abnormal_lacrimal_gland1.38133202
45MP0001905_abnormal_dopamine_level1.38021596
46MP0002876_abnormal_thyroid_physiology1.37952359
47MP0002735_abnormal_chemical_nociception1.34240174
48MP0002733_abnormal_thermal_nociception1.31821364
49MP0000678_abnormal_parathyroid_gland1.31324022
50MP0001968_abnormal_touch/_nociception1.30237777
51MP0000631_abnormal_neuroendocrine_gland1.29896793
52MP0005423_abnormal_somatic_nervous1.28619572
53MP0002822_catalepsy1.27549811
54MP0001188_hyperpigmentation1.26408810
55MP0000026_abnormal_inner_ear1.26260447
56MP0009745_abnormal_behavioral_response1.26197397
57MP0002557_abnormal_social/conspecific_i1.25352367
58MP0003879_abnormal_hair_cell1.24662682
59MP0002095_abnormal_skin_pigmentation1.24533090
60MP0001970_abnormal_pain_threshold1.21037620
61MP0005253_abnormal_eye_physiology1.19037256
62MP0003315_abnormal_perineum_morphology1.16557211
63MP0002234_abnormal_pharynx_morphology1.14165277
64MP0005084_abnormal_gallbladder_morpholo1.12747335
65MP0002928_abnormal_bile_duct1.12518106
66MP0002736_abnormal_nociception_after1.12086786
67MP0005195_abnormal_posterior_eye1.06192773
68MP0003635_abnormal_synaptic_transmissio1.00272699
69MP0002837_dystrophic_cardiac_calcinosis0.99834252
70MP0002752_abnormal_somatic_nervous0.99037087
71MP0002572_abnormal_emotion/affect_behav0.97233297
72MP0001502_abnormal_circadian_rhythm0.95512949
73MP0000778_abnormal_nervous_system0.92654839
74MP0002067_abnormal_sensory_capabilities0.91926736
75MP0002063_abnormal_learning/memory/cond0.91623389
76MP0001486_abnormal_startle_reflex0.89651484
77MP0002184_abnormal_innervation0.89628122
78MP0001963_abnormal_hearing_physiology0.87142927
79MP0000955_abnormal_spinal_cord0.84705897
80MP0004147_increased_porphyrin_level0.82963113
81MP0001529_abnormal_vocalization0.82551330
82MP0004859_abnormal_synaptic_plasticity0.81688654
83MP0000230_abnormal_systemic_arterial0.81652586
84MP0002938_white_spotting0.81079041
85MP0004019_abnormal_vitamin_homeostasis0.78438262
86MP0001293_anophthalmia0.77846875
87MP0005670_abnormal_white_adipose0.77302023
88MP0004130_abnormal_muscle_cell0.76910788
89MP0009765_abnormal_xenobiotic_induced0.75580010
90MP0003638_abnormal_response/metabolism_0.75299863
91MP0002064_seizures0.74778951
92MP0003936_abnormal_reproductive_system0.74113321
93MP0009333_abnormal_splenocyte_physiolog0.73593291
94MP0001986_abnormal_taste_sensitivity0.73012296
95MP0005174_abnormal_tail_pigmentation0.72780838
96MP0003119_abnormal_digestive_system0.72189762
97MP0002882_abnormal_neuron_morphology0.71146194
98MP0005410_abnormal_fertilization0.70753567
99MP0000685_abnormal_immune_system0.68729842
100MP0009764_decreased_sensitivity_to0.68329730

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.69391479
2Abnormal rod and cone electroretinograms (HP:0008323)3.92078614
3Reticulocytopenia (HP:0001896)3.79530493
4Abnormality of midbrain morphology (HP:0002418)3.76052834
5Molar tooth sign on MRI (HP:0002419)3.76052834
6Acute necrotizing encephalopathy (HP:0006965)3.61470611
7Pancreatic cysts (HP:0001737)3.48604361
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.47917316
9Pancreatic fibrosis (HP:0100732)3.28389885
10Acute encephalopathy (HP:0006846)3.24265628
11Mitochondrial inheritance (HP:0001427)3.19709078
12Abnormal mitochondria in muscle tissue (HP:0008316)3.18582930
13True hermaphroditism (HP:0010459)3.12491068
1411 pairs of ribs (HP:0000878)3.10399175
15Pendular nystagmus (HP:0012043)3.10078230
16Abnormality of cells of the erythroid lineage (HP:0012130)2.96244995
17Lipid accumulation in hepatocytes (HP:0006561)2.91035849
18Progressive macrocephaly (HP:0004481)2.83102754
19Aplasia/Hypoplasia of the spleen (HP:0010451)2.77316564
20Decreased central vision (HP:0007663)2.76582050
21Asplenia (HP:0001746)2.73229893
22Radial bowing (HP:0002986)2.62095829
23Short femoral neck (HP:0100864)2.60208930
24Increased CSF lactate (HP:0002490)2.57643886
253-Methylglutaconic aciduria (HP:0003535)2.53099776
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49129890
27Abolished electroretinogram (ERG) (HP:0000550)2.45116528
28Macrocytic anemia (HP:0001972)2.42504443
29Increased hepatocellular lipid droplets (HP:0006565)2.42120216
30Anencephaly (HP:0002323)2.41142690
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39960985
32Congenital, generalized hypertrichosis (HP:0004540)2.39878678
33Hyperglycinemia (HP:0002154)2.39353588
34Absent thumb (HP:0009777)2.37628686
35Hypoplasia of the ulna (HP:0003022)2.33778970
36Nephronophthisis (HP:0000090)2.31818779
37Hypoplasia of the radius (HP:0002984)2.30351255
38Abnormality of the renal medulla (HP:0100957)2.29088915
39Polydipsia (HP:0001959)2.27555630
40Abnormal drinking behavior (HP:0030082)2.27555630
41Palpebral edema (HP:0100540)2.26064955
42Type II lissencephaly (HP:0007260)2.22924352
43Cystic liver disease (HP:0006706)2.22733694
44Severe visual impairment (HP:0001141)2.21795028
45Forearm undergrowth (HP:0009821)2.20343748
46Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.18701176
47Abnormal number of erythroid precursors (HP:0012131)2.18197377
48Myokymia (HP:0002411)2.17249310
49Pallor (HP:0000980)2.08002954
50Attenuation of retinal blood vessels (HP:0007843)2.07836565
51Renal Fanconi syndrome (HP:0001994)2.06611012
52Abnormal respiratory epithelium morphology (HP:0012253)2.04066509
53Abnormal respiratory motile cilium morphology (HP:0005938)2.04066509
54Polyuria (HP:0000103)2.03558040
55Sclerocornea (HP:0000647)2.03182408
56Abnormality of the renal cortex (HP:0011035)2.03131826
57Septo-optic dysplasia (HP:0100842)2.03131424
58Medial flaring of the eyebrow (HP:0010747)2.03008132
59Optic disc pallor (HP:0000543)2.01201663
60Supernumerary spleens (HP:0009799)1.99033197
61Aplasia/Hypoplasia of the ulna (HP:0006495)1.98285056
62Increased muscle lipid content (HP:0009058)1.98239658
63IgG deficiency (HP:0004315)1.98178125
64Cerebral edema (HP:0002181)1.96797487
65Aplasia/hypoplasia of the uterus (HP:0008684)1.96259737
66Pachygyria (HP:0001302)1.92512472
67Chronic hepatic failure (HP:0100626)1.92490107
68Severe muscular hypotonia (HP:0006829)1.91734420
69Hepatocellular necrosis (HP:0001404)1.91568460
70Brushfield spots (HP:0001088)1.91352090
71Type 2 muscle fiber atrophy (HP:0003554)1.90011792
72Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89570081
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89570081
74Dyskinesia (HP:0100660)1.88947783
75Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.88889833
76Abnormality of the labia minora (HP:0012880)1.88074564
77Keratoconus (HP:0000563)1.87325914
78Increased corneal curvature (HP:0100692)1.87325914
79Increased intramyocellular lipid droplets (HP:0012240)1.87183859
80Hypoplasia of the uterus (HP:0000013)1.86714598
81Genetic anticipation (HP:0003743)1.84574622
82Enlarged kidneys (HP:0000105)1.83975440
83Aplasia/hypoplasia of the femur (HP:0005613)1.79702532
84Colon cancer (HP:0003003)1.77948740
85Postaxial foot polydactyly (HP:0001830)1.77216651
86Abnormality of renal excretion (HP:0011036)1.76991899
87Agitation (HP:0000713)1.75258792
88Gait imbalance (HP:0002141)1.73478881
89Abnormality of renal resorption (HP:0011038)1.72666440
90Abnormal ciliary motility (HP:0012262)1.72040829
91Oligodactyly (hands) (HP:0001180)1.71367267
92Symphalangism affecting the phalanges of the hand (HP:0009773)1.70935503
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.70804489
94Absent/shortened dynein arms (HP:0200106)1.70804489
95Maternal diabetes (HP:0009800)1.70209427
96Muscle fiber atrophy (HP:0100295)1.69963318
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69449347
98Broad distal phalanx of finger (HP:0009836)1.69262544
99Stenosis of the external auditory canal (HP:0000402)1.68226647
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67901539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.31162539
2TLK13.85543599
3STK393.68850520
4ZAK3.10792212
5ADRBK22.98110774
6CDC72.87622721
7TXK2.43268398
8WNK12.37794495
9GRK12.32402698
10BCKDK2.25119451
11BMPR1B1.99598021
12TIE11.79350434
13DYRK21.79007219
14CDK191.70078968
15VRK11.64859980
16KDR1.60499418
17PINK11.49321540
18AURKA1.40473627
19MAP4K11.30569601
20RPS6KA51.28728273
21CAMKK21.28380953
22MAP2K71.28034005
23CAMKK11.27287456
24STK161.24975895
25LIMK11.24758191
26PRKCQ1.23801141
27PIK3CA1.21579554
28NTRK21.17857321
29MAP4K21.16705237
30TESK21.14176281
31FRK1.11634751
32INSRR1.10450909
33MAP3K41.08002975
34CSNK1G31.01498631
35EPHB21.01233290
36BRSK10.98131140
37MAP3K110.95232076
38MARK30.95047381
39PKN10.93358740
40TAOK30.90238352
41TYRO30.86780916
42NUAK10.86287961
43CSNK1G20.85247427
44TAF10.82295931
45ITK0.81350926
46NTRK30.80600836
47PIM20.79228400
48CSNK1G10.78556253
49CSNK1A1L0.76781686
50DAPK30.76378073
51VRK20.75810074
52CAMK10.74785118
53SYK0.73000813
54IKBKB0.71533259
55OBSCN0.71322653
56OXSR10.70349235
57ADRBK10.69996044
58TEC0.69948047
59SIK20.68962422
60PRKCG0.68196706
61WNK30.67313762
62NEK20.65236236
63PRKACA0.64859167
64MAPK130.64487272
65CASK0.61100359
66ABL20.60786622
67PIM10.58800718
68PHKG20.56530797
69PHKG10.56530797
70NME20.55926687
71TRIM280.55917248
72AURKB0.54498842
73CSNK2A20.53246615
74MAPK150.51377718
75MARK10.50961023
76IKBKE0.50876314
77TGFBR10.49035160
78SGK4940.48809638
79SGK2230.48809638
80CAMK2A0.48642478
81MAP2K20.48639141
82CSNK1A10.48472778
83CSNK1E0.46954610
84ATR0.46704613
85NME10.45711319
86CSNK2A10.44638498
87PAK30.44356558
88BTK0.44133914
89DYRK1B0.43810071
90LYN0.40388278
91STK110.38598885
92IRAK40.38049494
93DAPK20.38023195
94PRKCA0.36979999
95PRKCI0.36335126
96GRK70.35548716
97CHEK20.34667951
98FES0.33360893
99PLK10.32445467
100PRKCH0.31523147

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.67533430
2Oxidative phosphorylation_Homo sapiens_hsa001903.73093139
3Parkinsons disease_Homo sapiens_hsa050123.05359482
4Cardiac muscle contraction_Homo sapiens_hsa042602.88731977
5Autoimmune thyroid disease_Homo sapiens_hsa053202.65517963
6Allograft rejection_Homo sapiens_hsa053302.64284154
7Graft-versus-host disease_Homo sapiens_hsa053322.52041837
8Phototransduction_Homo sapiens_hsa047442.46557146
9Systemic lupus erythematosus_Homo sapiens_hsa053222.40086818
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.28523426
11Primary immunodeficiency_Homo sapiens_hsa053402.25673159
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17566362
13Asthma_Homo sapiens_hsa053102.11725032
14Alzheimers disease_Homo sapiens_hsa050102.04265820
15Type I diabetes mellitus_Homo sapiens_hsa049401.98920856
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90227198
17Huntingtons disease_Homo sapiens_hsa050161.82513974
18Nicotine addiction_Homo sapiens_hsa050331.70866898
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68560912
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67591591
21Alcoholism_Homo sapiens_hsa050341.47324233
22Selenocompound metabolism_Homo sapiens_hsa004501.47143556
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46762339
24Linoleic acid metabolism_Homo sapiens_hsa005911.44375462
25Proteasome_Homo sapiens_hsa030501.37057439
26Antigen processing and presentation_Homo sapiens_hsa046121.35483186
27Olfactory transduction_Homo sapiens_hsa047401.34623479
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29634053
29Caffeine metabolism_Homo sapiens_hsa002321.26061744
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19674473
31Homologous recombination_Homo sapiens_hsa034401.18403975
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18076111
33Nitrogen metabolism_Homo sapiens_hsa009101.17027852
34Protein export_Homo sapiens_hsa030601.16973049
35Morphine addiction_Homo sapiens_hsa050321.12545729
36Sulfur relay system_Homo sapiens_hsa041221.11964210
37Collecting duct acid secretion_Homo sapiens_hsa049661.11204138
38Viral myocarditis_Homo sapiens_hsa054161.08089432
39Rheumatoid arthritis_Homo sapiens_hsa053230.99236215
40RNA polymerase_Homo sapiens_hsa030200.97802772
41Hedgehog signaling pathway_Homo sapiens_hsa043400.96822332
42Peroxisome_Homo sapiens_hsa041460.96156046
43Pyrimidine metabolism_Homo sapiens_hsa002400.93988410
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90554462
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89191197
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86225713
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86061958
48Ether lipid metabolism_Homo sapiens_hsa005650.84449419
49RNA degradation_Homo sapiens_hsa030180.83449487
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82354355
51GABAergic synapse_Homo sapiens_hsa047270.81907092
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80840984
53Retinol metabolism_Homo sapiens_hsa008300.78968595
54Regulation of autophagy_Homo sapiens_hsa041400.76602806
55Hematopoietic cell lineage_Homo sapiens_hsa046400.76551130
56Fanconi anemia pathway_Homo sapiens_hsa034600.75276245
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72940271
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69730650
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68843919
60Insulin secretion_Homo sapiens_hsa049110.68595074
61Fat digestion and absorption_Homo sapiens_hsa049750.65456393
62Butanoate metabolism_Homo sapiens_hsa006500.65369611
63Circadian entrainment_Homo sapiens_hsa047130.63887327
64Chemical carcinogenesis_Homo sapiens_hsa052040.61448871
65Serotonergic synapse_Homo sapiens_hsa047260.59717193
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59532034
67Taste transduction_Homo sapiens_hsa047420.59060246
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.56103213
69Tryptophan metabolism_Homo sapiens_hsa003800.54273047
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54065970
71Purine metabolism_Homo sapiens_hsa002300.50913712
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50430931
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50224542
74One carbon pool by folate_Homo sapiens_hsa006700.50213402
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.50063396
76Synaptic vesicle cycle_Homo sapiens_hsa047210.48568875
77Basal cell carcinoma_Homo sapiens_hsa052170.48188738
78Glycerolipid metabolism_Homo sapiens_hsa005610.47458612
79Arachidonic acid metabolism_Homo sapiens_hsa005900.44303779
80Metabolic pathways_Homo sapiens_hsa011000.43964174
81Glutamatergic synapse_Homo sapiens_hsa047240.42929720
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42758167
83Oxytocin signaling pathway_Homo sapiens_hsa049210.42039503
84DNA replication_Homo sapiens_hsa030300.41605656
85Cholinergic synapse_Homo sapiens_hsa047250.39884765
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38855997
87Dilated cardiomyopathy_Homo sapiens_hsa054140.38323464
88Gastric acid secretion_Homo sapiens_hsa049710.37000964
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36848034
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.34464025
91Basal transcription factors_Homo sapiens_hsa030220.32379813
92Steroid biosynthesis_Homo sapiens_hsa001000.30885527
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30430775
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30074751
95Dopaminergic synapse_Homo sapiens_hsa047280.29294842
96Ovarian steroidogenesis_Homo sapiens_hsa049130.28915221
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28492339
98Calcium signaling pathway_Homo sapiens_hsa040200.28183343
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28142621
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25912222

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