PTMAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.69839760
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.69839760
3ribosomal small subunit assembly (GO:0000028)5.57508032
4ATP synthesis coupled proton transport (GO:0015986)4.89171521
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.89171521
6chaperone-mediated protein transport (GO:0072321)4.87424858
7response to pheromone (GO:0019236)4.82617858
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50659405
9rRNA modification (GO:0000154)4.49611277
10regulation of gonadotropin secretion (GO:0032276)4.47566768
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.42693963
12protein neddylation (GO:0045116)4.37113224
13viral transcription (GO:0019083)4.29896192
14folic acid-containing compound biosynthetic process (GO:0009396)4.26262590
15translational termination (GO:0006415)4.23791845
16DNA deamination (GO:0045006)4.22119576
17chromatin remodeling at centromere (GO:0031055)4.21661823
18rRNA methylation (GO:0031167)4.11673330
19ribosomal small subunit biogenesis (GO:0042274)4.05576352
20behavioral response to nicotine (GO:0035095)4.01619215
21CENP-A containing nucleosome assembly (GO:0034080)3.93378487
22positive regulation of growth hormone secretion (GO:0060124)3.92425518
23water-soluble vitamin biosynthetic process (GO:0042364)3.79497784
24maturation of SSU-rRNA (GO:0030490)3.76403473
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69109456
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.69109456
27NADH dehydrogenase complex assembly (GO:0010257)3.69109456
28protein complex biogenesis (GO:0070271)3.63627964
29L-serine metabolic process (GO:0006563)3.60370412
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59475387
31translational elongation (GO:0006414)3.58885929
32cotranslational protein targeting to membrane (GO:0006613)3.54294404
33protein targeting to ER (GO:0045047)3.52703036
34histone exchange (GO:0043486)3.49140855
35electron transport chain (GO:0022900)3.44003775
36respiratory electron transport chain (GO:0022904)3.43327823
37homocysteine metabolic process (GO:0050667)3.43249417
38mitochondrial respiratory chain complex assembly (GO:0033108)3.40162531
39protein polyglutamylation (GO:0018095)3.34202882
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33788316
41cellular protein complex disassembly (GO:0043624)3.32656098
42proteasome assembly (GO:0043248)3.32023178
43protein localization to endoplasmic reticulum (GO:0070972)3.31557657
44sperm motility (GO:0030317)3.31046732
45ribonucleoprotein complex biogenesis (GO:0022613)3.30064030
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27604482
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.25446138
48termination of RNA polymerase III transcription (GO:0006386)3.25446138
49ncRNA 3-end processing (GO:0043628)3.24807777
50ribosome biogenesis (GO:0042254)3.24287327
51cellular component biogenesis (GO:0044085)3.23802046
52tRNA processing (GO:0008033)3.23255535
53negative regulation of telomerase activity (GO:0051974)3.23208603
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17319798
55GTP biosynthetic process (GO:0006183)3.16992049
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16097084
57rRNA processing (GO:0006364)3.13402427
58viral life cycle (GO:0019058)3.13177522
59acrosome reaction (GO:0007340)3.12739726
60negative regulation of DNA biosynthetic process (GO:2000279)3.09680077
61translation (GO:0006412)3.08210886
62pseudouridine synthesis (GO:0001522)3.05503826
63cytidine deamination (GO:0009972)3.01880804
64cytidine metabolic process (GO:0046087)3.01880804
65cytidine catabolic process (GO:0006216)3.01880804
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01701570
67regulation of growth hormone secretion (GO:0060123)3.01667847
68microtubule depolymerization (GO:0007019)3.01618843
69rRNA metabolic process (GO:0016072)3.00611833
70regulation of cilium movement (GO:0003352)3.00052996
71hydrogen ion transmembrane transport (GO:1902600)2.99994482
72translational initiation (GO:0006413)2.99704510
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99645627
74protein-cofactor linkage (GO:0018065)2.98571305
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98392772
76RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.97503001
77ribosomal large subunit biogenesis (GO:0042273)2.96299867
78tetrahydrofolate metabolic process (GO:0046653)2.94294094
79ATP biosynthetic process (GO:0006754)2.94167810
80cellular ketone body metabolic process (GO:0046950)2.94026329
81serine family amino acid biosynthetic process (GO:0009070)2.93982118
82protein complex disassembly (GO:0043241)2.93679991
83nonmotile primary cilium assembly (GO:0035058)2.90021511
84pteridine-containing compound biosynthetic process (GO:0042559)2.89491680
85axonemal dynein complex assembly (GO:0070286)2.85051720
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84764294
87tRNA modification (GO:0006400)2.84341030
88DNA replication-independent nucleosome organization (GO:0034724)2.84263831
89DNA replication-independent nucleosome assembly (GO:0006336)2.84263831
90regulation of plasminogen activation (GO:0010755)2.83040349
91macromolecular complex disassembly (GO:0032984)2.79149788
92fusion of sperm to egg plasma membrane (GO:0007342)2.78805362
93intracellular protein transmembrane import (GO:0044743)2.77287546
94regulation of telomerase activity (GO:0051972)2.76664277
95UTP biosynthetic process (GO:0006228)2.75320138
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74433803
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74259023
98proton transport (GO:0015992)2.72590489
99tRNA metabolic process (GO:0006399)2.71797566
100sperm-egg recognition (GO:0035036)2.71582109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.06378061
2EZH2_22144423_ChIP-Seq_EOC_Human5.04597024
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.10489779
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.85479253
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.53443358
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36254528
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.72716373
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63375121
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51177346
10VDR_22108803_ChIP-Seq_LS180_Human2.46882688
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42730786
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.31155913
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.02534640
14E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82776463
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79601424
16ZNF274_21170338_ChIP-Seq_K562_Hela1.77833668
17E2F7_22180533_ChIP-Seq_HELA_Human1.65904026
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64042162
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60178179
20IRF1_19129219_ChIP-ChIP_H3396_Human1.58044582
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54271719
22FOXP3_21729870_ChIP-Seq_TREG_Human1.53320160
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49837372
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48679481
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45601905
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45515131
27VDR_23849224_ChIP-Seq_CD4+_Human1.41862897
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40713564
29MYC_18940864_ChIP-ChIP_HL60_Human1.39897057
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.37776222
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35263633
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33939957
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33001337
34GABP_19822575_ChIP-Seq_HepG2_Human1.32521727
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32062333
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31374764
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31238808
38TAF2_19829295_ChIP-Seq_ESCs_Human1.29298528
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28612003
40TTF2_22483619_ChIP-Seq_HELA_Human1.28405605
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28403211
42NANOG_20526341_ChIP-Seq_ESCs_Human1.27783281
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25263981
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23666695
45ELK1_19687146_ChIP-ChIP_HELA_Human1.22905705
46ERA_21632823_ChIP-Seq_H3396_Human1.22158364
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21412456
48NCOR_22424771_ChIP-Seq_293T_Human1.21061928
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.19283004
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17800182
51TP53_22573176_ChIP-Seq_HFKS_Human1.17231841
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15564323
53REST_21632747_ChIP-Seq_MESCs_Mouse1.15537681
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.14257761
55XRN2_22483619_ChIP-Seq_HELA_Human1.11928439
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.11240163
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.08627289
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08348128
59E2F1_20622854_ChIP-Seq_HELA_Human1.07197709
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06753714
61STAT1_20625510_ChIP-Seq_HELA_Human1.06614232
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.05481957
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04860483
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04721240
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04331336
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.04065083
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02693596
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.02447283
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99343902
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99343902
71CBX2_27304074_Chip-Seq_ESCs_Mouse0.97274847
72CTCF_20526341_ChIP-Seq_ESCs_Human0.95837583
73E2F1_21310950_ChIP-Seq_MCF-7_Human0.95819415
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95419146
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95365591
76STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95052391
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93798496
78AR_21572438_ChIP-Seq_LNCaP_Human0.92523846
79CTCF_27219007_Chip-Seq_Bcells_Human0.92048779
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91955767
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91122372
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91103105
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.90470023
84P53_21459846_ChIP-Seq_SAOS-2_Human0.90266060
85P300_27268052_Chip-Seq_Bcells_Human0.89949221
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88964133
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.88960145
88HOXB7_26014856_ChIP-Seq_BT474_Human0.88582267
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.88193514
90MYC_19829295_ChIP-Seq_ESCs_Human0.87761742
91FOXH1_21741376_ChIP-Seq_ESCs_Human0.87576317
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.87305992
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85675064
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85388546
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84197402
96EWS_26573619_Chip-Seq_HEK293_Human0.83738741
97NANOG_19829295_ChIP-Seq_ESCs_Human0.82852454
98SOX2_19829295_ChIP-Seq_ESCs_Human0.82852454
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82835318
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81159542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.22796741
2MP0002163_abnormal_gland_morphology4.09665911
3MP0006292_abnormal_olfactory_placode3.94567856
4MP0005646_abnormal_pituitary_gland3.15198556
5MP0009379_abnormal_foot_pigmentation2.94151523
6MP0003878_abnormal_ear_physiology2.88420613
7MP0005377_hearing/vestibular/ear_phenot2.88420613
8MP0003787_abnormal_imprinting2.68927626
9MP0008877_abnormal_DNA_methylation2.65530991
10MP0005379_endocrine/exocrine_gland_phen2.36569001
11MP0008789_abnormal_olfactory_epithelium2.34310526
12MP0003123_paternal_imprinting2.23095067
13MP0003122_maternal_imprinting2.22193428
14MP0005410_abnormal_fertilization2.12965492
15MP0001984_abnormal_olfaction1.96276390
16MP0005394_taste/olfaction_phenotype1.95029525
17MP0005499_abnormal_olfactory_system1.95029525
18MP0002234_abnormal_pharynx_morphology1.82529036
19MP0005670_abnormal_white_adipose1.82044047
20MP0008872_abnormal_physiological_respon1.79899257
21MP0002938_white_spotting1.79006457
22MP0005423_abnormal_somatic_nervous1.78710068
23MP0003121_genomic_imprinting1.72445776
24MP0001485_abnormal_pinna_reflex1.66057286
25MP0002736_abnormal_nociception_after1.65476953
26MP0000613_abnormal_salivary_gland1.64586522
27MP0004885_abnormal_endolymph1.61316864
28MP0003718_maternal_effect1.60360608
29MP0006276_abnormal_autonomic_nervous1.56091657
30MP0001293_anophthalmia1.55571188
31MP0002102_abnormal_ear_morphology1.55532841
32MP0003315_abnormal_perineum_morphology1.54420857
33MP0003880_abnormal_central_pattern1.45802691
34MP0004142_abnormal_muscle_tone1.42613361
35MP0001968_abnormal_touch/_nociception1.39362819
36MP0004145_abnormal_muscle_electrophysio1.38549182
37MP0005551_abnormal_eye_electrophysiolog1.37280656
38MP0000049_abnormal_middle_ear1.32804794
39MP0003693_abnormal_embryo_hatching1.32261405
40MP0008995_early_reproductive_senescence1.29118526
41MP0003011_delayed_dark_adaptation1.27969791
42MP0002876_abnormal_thyroid_physiology1.27753650
43MP0002653_abnormal_ependyma_morphology1.26508002
44MP0003786_premature_aging1.25766148
45MP0010094_abnormal_chromosome_stability1.21480393
46MP0002733_abnormal_thermal_nociception1.21230806
47MP0004133_heterotaxia1.20085137
48MP0001440_abnormal_grooming_behavior1.18080569
49MP0001529_abnormal_vocalization1.17641398
50MP0002210_abnormal_sex_determination1.17118208
51MP0002557_abnormal_social/conspecific_i1.16844495
52MP0000026_abnormal_inner_ear1.16283698
53MP0001486_abnormal_startle_reflex1.15514673
54MP0000647_abnormal_sebaceous_gland1.14042186
55MP0003698_abnormal_male_reproductive1.13700649
56MP0008058_abnormal_DNA_repair1.13612831
57MP0009745_abnormal_behavioral_response1.13142307
58MP0004147_increased_porphyrin_level1.12625000
59MP0001929_abnormal_gametogenesis1.12332702
60MP0005084_abnormal_gallbladder_morpholo1.11893969
61MP0003646_muscle_fatigue1.09901727
62MP0000631_abnormal_neuroendocrine_gland1.09606272
63MP0002184_abnormal_innervation1.07901480
64MP0001970_abnormal_pain_threshold1.07234244
65MP0002138_abnormal_hepatobiliary_system1.06129139
66MP0002735_abnormal_chemical_nociception1.05633697
67MP0003806_abnormal_nucleotide_metabolis1.04058040
68MP0002272_abnormal_nervous_system1.03510194
69MP0001963_abnormal_hearing_physiology1.02103211
70MP0002095_abnormal_skin_pigmentation1.00025143
71MP0002160_abnormal_reproductive_system0.97005529
72MP0001905_abnormal_dopamine_level0.95807051
73MP0003936_abnormal_reproductive_system0.94297729
74MP0002572_abnormal_emotion/affect_behav0.92706187
75MP0009046_muscle_twitch0.90636830
76MP0000678_abnormal_parathyroid_gland0.89719151
77MP0003186_abnormal_redox_activity0.89089255
78MP0002277_abnormal_respiratory_mucosa0.88264037
79MP0002752_abnormal_somatic_nervous0.87451858
80MP0000653_abnormal_sex_gland0.87170616
81MP0005195_abnormal_posterior_eye0.87003662
82MP0002734_abnormal_mechanical_nocicepti0.85439135
83MP0003635_abnormal_synaptic_transmissio0.84002168
84MP0005389_reproductive_system_phenotype0.83526597
85MP0003942_abnormal_urinary_system0.83469351
86MP0001286_abnormal_eye_development0.82213025
87MP0001919_abnormal_reproductive_system0.80980449
88MP0005253_abnormal_eye_physiology0.80630304
89MP0009764_decreased_sensitivity_to0.80030034
90MP0000955_abnormal_spinal_cord0.79672679
91MP0005360_urolithiasis0.78087585
92MP0001145_abnormal_male_reproductive0.77607146
93MP0002063_abnormal_learning/memory/cond0.76341067
94MP0003119_abnormal_digestive_system0.75376254
95MP0000534_abnormal_ureter_morphology0.73533257
96MP0000778_abnormal_nervous_system0.71590904
97MP0002233_abnormal_nose_morphology0.71578332
98MP0006072_abnormal_retinal_apoptosis0.71466865
99MP0005636_abnormal_mineral_homeostasis0.71231009
100MP0003111_abnormal_nucleus_morphology0.70454378

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.15575600
2Acute encephalopathy (HP:0006846)3.80893134
3Abnormality of the labia minora (HP:0012880)3.69098616
4Pancreatic fibrosis (HP:0100732)3.63774252
5Abnormal mitochondria in muscle tissue (HP:0008316)3.54274367
6Reticulocytopenia (HP:0001896)3.44299800
7Mitochondrial inheritance (HP:0001427)3.37418179
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.36714652
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35474676
10Abnormality of alanine metabolism (HP:0010916)3.35474676
11Hyperalaninemia (HP:0003348)3.35474676
12Severe visual impairment (HP:0001141)3.22796792
13Pancreatic cysts (HP:0001737)3.21615318
14Progressive macrocephaly (HP:0004481)3.18762531
15Abnormality of midbrain morphology (HP:0002418)3.03854111
16Molar tooth sign on MRI (HP:0002419)3.03854111
17Increased CSF lactate (HP:0002490)3.00944730
18Aplasia/Hypoplasia of the spleen (HP:0010451)2.89468507
19Asplenia (HP:0001746)2.88466378
20Abnormal respiratory motile cilium morphology (HP:0005938)2.84387299
21Abnormal respiratory epithelium morphology (HP:0012253)2.84387299
22True hermaphroditism (HP:0010459)2.83395134
23Constricted visual fields (HP:0001133)2.82846698
24Pendular nystagmus (HP:0012043)2.71786315
25Supernumerary spleens (HP:0009799)2.68788905
26Optic disc pallor (HP:0000543)2.66361461
27Cerebral edema (HP:0002181)2.65837890
28Abnormality of cells of the erythroid lineage (HP:0012130)2.65719810
29Abnormal rod and cone electroretinograms (HP:0008323)2.65161234
30Optic nerve coloboma (HP:0000588)2.62554109
31Hepatocellular necrosis (HP:0001404)2.52144502
32Chronic hepatic failure (HP:0100626)2.50569223
33Increased hepatocellular lipid droplets (HP:0006565)2.45685351
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.45136144
35Absent/shortened dynein arms (HP:0200106)2.45136144
36Anencephaly (HP:0002323)2.41354071
37Renal Fanconi syndrome (HP:0001994)2.40272026
38Attenuation of retinal blood vessels (HP:0007843)2.39864803
39Sclerocornea (HP:0000647)2.39477617
40Methylmalonic acidemia (HP:0002912)2.38460315
41Methylmalonic aciduria (HP:0012120)2.37014074
42Nephronophthisis (HP:0000090)2.35133213
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34633887
44Colon cancer (HP:0003003)2.32547672
45Hyperglycinemia (HP:0002154)2.32514468
46Absent thumb (HP:0009777)2.30858480
47Decreased central vision (HP:0007663)2.30492970
48Progressive cerebellar ataxia (HP:0002073)2.28544739
49Hepatic necrosis (HP:0002605)2.27585306
50Increased serum lactate (HP:0002151)2.27057089
51Macrocytic anemia (HP:0001972)2.26149934
52Bile duct proliferation (HP:0001408)2.25043745
53Abnormal biliary tract physiology (HP:0012439)2.25043745
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25042971
553-Methylglutaconic aciduria (HP:0003535)2.24741200
56Chromsome breakage (HP:0040012)2.23910463
57Abnormal ciliary motility (HP:0012262)2.23714697
58Lipid accumulation in hepatocytes (HP:0006561)2.22656564
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22598773
60Pallor (HP:0000980)2.21614504
61Birth length less than 3rd percentile (HP:0003561)2.20766573
62Abnormal number of erythroid precursors (HP:0012131)2.16415938
63Anosmia (HP:0000458)2.14865129
64Abnormality of serum amino acid levels (HP:0003112)2.12655193
65Myokymia (HP:0002411)2.11736922
66Oligodactyly (hands) (HP:0001180)2.10941102
67Abnormality of DNA repair (HP:0003254)2.08370632
68Stenosis of the external auditory canal (HP:0000402)2.08061243
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.05624927
70Cystic liver disease (HP:0006706)2.01626644
71Congenital sensorineural hearing impairment (HP:0008527)2.00281056
72Abnormal respiratory motile cilium physiology (HP:0012261)1.95685950
73Leukodystrophy (HP:0002415)1.92442076
74Abnormality of the renal collecting system (HP:0004742)1.90407252
75Chronic sinusitis (HP:0011109)1.90209022
76Hypogonadotrophic hypogonadism (HP:0000044)1.88331956
77Lactic acidosis (HP:0003128)1.88161049
78Abnormality of the renal medulla (HP:0100957)1.87419452
79Bony spicule pigmentary retinopathy (HP:0007737)1.87412743
80Impulsivity (HP:0100710)1.86906382
81Abnormality of the ileum (HP:0001549)1.86770970
82Maternal diabetes (HP:0009800)1.86287270
83Abolished electroretinogram (ERG) (HP:0000550)1.85525079
84Congenital stationary night blindness (HP:0007642)1.85486437
85Horseshoe kidney (HP:0000085)1.85094238
86Hypoplastic pelvis (HP:0008839)1.83814282
87Medial flaring of the eyebrow (HP:0010747)1.83655538
88Meckel diverticulum (HP:0002245)1.80950215
89Cerebral hypomyelination (HP:0006808)1.80599053
90Septo-optic dysplasia (HP:0100842)1.77610179
91Abnormal drinking behavior (HP:0030082)1.74208008
92Polydipsia (HP:0001959)1.74208008
93Abnormality of urine glucose concentration (HP:0011016)1.74153045
94Glycosuria (HP:0003076)1.74153045
95Ectopic kidney (HP:0000086)1.72903241
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72415029
97Preaxial hand polydactyly (HP:0001177)1.71803292
98Depressed nasal ridge (HP:0000457)1.70996616
99Postaxial foot polydactyly (HP:0001830)1.69198164
100Lethargy (HP:0001254)1.66659570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.58010979
2VRK23.55802664
3BUB13.39888817
4TLK13.24494776
5TRIM282.95051710
6WNK42.92445638
7TAF12.63162225
8NUAK12.36217345
9CDC72.31654794
10DYRK22.19000471
11VRK12.14722534
12NME12.04090265
13SMG11.94383325
14INSRR1.90809828
15PLK41.84909091
16STK161.84663127
17LMTK21.82525657
18NEK11.67996253
19ADRBK21.55486422
20STK391.52626588
21BMPR1B1.43298336
22GRK11.41830716
23AURKA1.27760690
24PLK31.20551017
25WNK31.16649978
26MAP4K21.11517581
27WNK11.07089694
28EPHB21.04258767
29PLK11.02255556
30RPS6KB20.99702356
31PNCK0.98717758
32OXSR10.98553434
33NTRK20.96223257
34EIF2AK10.95484173
35EIF2AK30.94285925
36ACVR1B0.93754110
37PLK20.91138431
38FRK0.90018864
39DAPK30.85615262
40PRKCG0.84862196
41AURKB0.84760182
42MKNK20.82902261
43CHEK20.82123575
44EIF2AK20.80957273
45BCKDK0.78106746
46CDK90.77803515
47PHKG10.76166430
48PHKG20.76166430
49CSNK1G20.75720117
50MST40.75343740
51PIK3CA0.74718121
52ADRBK10.71382561
53ATR0.70969688
54PRKCI0.70380462
55TXK0.70007852
56TTK0.67430620
57CAMK10.67074646
58MARK10.64955253
59PRKCQ0.63845983
60TNIK0.62719934
61CSNK1G30.61439034
62PDK20.61356885
63MINK10.59575454
64TYRO30.59463328
65CSNK1A10.59221699
66MAP2K70.56777999
67CSNK1E0.55442202
68STK38L0.53070961
69TIE10.50691934
70EPHA20.50253862
71PKN10.50250734
72SGK4940.49717859
73SGK2230.49717859
74CSNK1G10.49502370
75CAMK1G0.48661966
76MAPK150.47338394
77MAP3K110.47214791
78CDK70.47145848
79CSNK2A20.46755984
80DAPK10.46332634
81PTK60.43828983
82CSNK2A10.43483796
83PRKCH0.42095651
84CHEK10.39790569
85CASK0.39591519
86CSNK1A1L0.39288063
87NEK20.39097177
88TSSK60.38955562
89PRKCD0.38460178
90GRK50.36877175
91ABL20.35889129
92PRKACA0.35549858
93RPS6KA50.35239288
94MAPKAPK50.34391251
95PRKCE0.34278946
96MAP3K40.33058493
97PINK10.32817380
98PRKCA0.32334958
99CDK190.31922881
100ALK0.29951909

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.42747057
2Oxidative phosphorylation_Homo sapiens_hsa001903.75019818
3Proteasome_Homo sapiens_hsa030503.50106553
4Parkinsons disease_Homo sapiens_hsa050123.08461938
5One carbon pool by folate_Homo sapiens_hsa006702.90453313
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64298093
7Mismatch repair_Homo sapiens_hsa034302.47197688
8RNA polymerase_Homo sapiens_hsa030202.44460019
9Huntingtons disease_Homo sapiens_hsa050162.39655559
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28622169
11Cardiac muscle contraction_Homo sapiens_hsa042602.23206692
12Homologous recombination_Homo sapiens_hsa034402.18619939
13Alzheimers disease_Homo sapiens_hsa050102.02210069
14DNA replication_Homo sapiens_hsa030301.99165870
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94111595
16Protein export_Homo sapiens_hsa030601.90612622
17Basal transcription factors_Homo sapiens_hsa030221.82745467
18RNA degradation_Homo sapiens_hsa030181.69906000
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63388110
20Nucleotide excision repair_Homo sapiens_hsa034201.53397426
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48519051
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36296642
23Fanconi anemia pathway_Homo sapiens_hsa034601.35841248
24RNA transport_Homo sapiens_hsa030131.35722205
25Butanoate metabolism_Homo sapiens_hsa006501.34157619
26Linoleic acid metabolism_Homo sapiens_hsa005911.32093297
27Pyrimidine metabolism_Homo sapiens_hsa002401.28251183
28Spliceosome_Homo sapiens_hsa030401.24194041
29Systemic lupus erythematosus_Homo sapiens_hsa053221.18680629
30Collecting duct acid secretion_Homo sapiens_hsa049661.18082529
31Non-homologous end-joining_Homo sapiens_hsa034501.16102226
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15218923
33Purine metabolism_Homo sapiens_hsa002301.10976478
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.08418494
35Base excision repair_Homo sapiens_hsa034101.06823242
36Nicotine addiction_Homo sapiens_hsa050331.05363459
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01314232
38Sulfur relay system_Homo sapiens_hsa041221.00710970
39Type I diabetes mellitus_Homo sapiens_hsa049400.99461860
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99439689
41Propanoate metabolism_Homo sapiens_hsa006400.96284071
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95911425
43Peroxisome_Homo sapiens_hsa041460.95024134
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94996551
45Morphine addiction_Homo sapiens_hsa050320.93924838
46Selenocompound metabolism_Homo sapiens_hsa004500.91135588
47Steroid biosynthesis_Homo sapiens_hsa001000.90949281
48Olfactory transduction_Homo sapiens_hsa047400.90437788
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88482660
50Phototransduction_Homo sapiens_hsa047440.85740821
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.79176346
52Folate biosynthesis_Homo sapiens_hsa007900.78286754
53Arginine biosynthesis_Homo sapiens_hsa002200.77745189
54Ether lipid metabolism_Homo sapiens_hsa005650.77406703
55Primary immunodeficiency_Homo sapiens_hsa053400.76361561
56Allograft rejection_Homo sapiens_hsa053300.76163590
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74471731
58Vitamin B6 metabolism_Homo sapiens_hsa007500.72914705
59Fat digestion and absorption_Homo sapiens_hsa049750.72300568
60Metabolic pathways_Homo sapiens_hsa011000.72075356
61Autoimmune thyroid disease_Homo sapiens_hsa053200.70778580
62Caffeine metabolism_Homo sapiens_hsa002320.69832264
63GABAergic synapse_Homo sapiens_hsa047270.67355808
64Asthma_Homo sapiens_hsa053100.66392926
65Retinol metabolism_Homo sapiens_hsa008300.64244353
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64235102
67Arginine and proline metabolism_Homo sapiens_hsa003300.64213295
68Glutamatergic synapse_Homo sapiens_hsa047240.62579515
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62424646
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.60239313
71Taste transduction_Homo sapiens_hsa047420.59926327
72Tryptophan metabolism_Homo sapiens_hsa003800.59009747
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58529553
74Biosynthesis of amino acids_Homo sapiens_hsa012300.57376849
75Alcoholism_Homo sapiens_hsa050340.57172952
76Pyruvate metabolism_Homo sapiens_hsa006200.56916015
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55952201
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54553145
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53932320
80Chemical carcinogenesis_Homo sapiens_hsa052040.52121651
81mRNA surveillance pathway_Homo sapiens_hsa030150.50836459
82Serotonergic synapse_Homo sapiens_hsa047260.50744661
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45278784
84Vibrio cholerae infection_Homo sapiens_hsa051100.44865960
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43414354
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43351459
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42535655
88Graft-versus-host disease_Homo sapiens_hsa053320.41686572
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.41346691
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41097215
91Arachidonic acid metabolism_Homo sapiens_hsa005900.38832336
92Synaptic vesicle cycle_Homo sapiens_hsa047210.37612820
93Glutathione metabolism_Homo sapiens_hsa004800.35580542
94Rheumatoid arthritis_Homo sapiens_hsa053230.32725013
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32700619
96Vitamin digestion and absorption_Homo sapiens_hsa049770.30799352
97Carbon metabolism_Homo sapiens_hsa012000.30212769
98Nitrogen metabolism_Homo sapiens_hsa009100.29160607
99Basal cell carcinoma_Homo sapiens_hsa052170.28142397
100Regulation of autophagy_Homo sapiens_hsa041400.26820303

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