PTMAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.97132561
2maturation of SSU-rRNA (GO:0030490)5.95441790
3ATP synthesis coupled proton transport (GO:0015986)5.73977239
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73977239
5translational termination (GO:0006415)5.72769702
6ribosomal small subunit biogenesis (GO:0042274)5.67179699
7ribosomal small subunit assembly (GO:0000028)5.50150916
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.45590569
9translational elongation (GO:0006414)4.90235924
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.87384215
11cotranslational protein targeting to membrane (GO:0006613)4.82557207
12protein targeting to ER (GO:0045047)4.79608649
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.69233254
14chaperone-mediated protein transport (GO:0072321)4.66496186
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.56315125
16protein localization to endoplasmic reticulum (GO:0070972)4.53806295
17behavioral response to nicotine (GO:0035095)4.50446889
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.47755061
19viral life cycle (GO:0019058)4.38161753
20cellular protein complex disassembly (GO:0043624)4.36796178
21ribosomal large subunit biogenesis (GO:0042273)4.27717967
22respiratory electron transport chain (GO:0022904)4.20057593
23electron transport chain (GO:0022900)4.19444027
24DNA deamination (GO:0045006)4.17845496
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.11447138
26protein neddylation (GO:0045116)4.05831641
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.96650948
28NADH dehydrogenase complex assembly (GO:0010257)3.96650948
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96650948
30translational initiation (GO:0006413)3.95513111
31protein complex biogenesis (GO:0070271)3.92954880
32protein complex disassembly (GO:0043241)3.74734646
33mitochondrial respiratory chain complex assembly (GO:0033108)3.65590793
34macromolecular complex disassembly (GO:0032984)3.59034771
35translation (GO:0006412)3.56185426
36ribonucleoprotein complex biogenesis (GO:0022613)3.54589944
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49980747
38cellular component biogenesis (GO:0044085)3.47935552
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39094207
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36442560
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36442560
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31646359
43auditory receptor cell differentiation (GO:0042491)3.27798091
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.27172896
45termination of RNA polymerase III transcription (GO:0006386)3.27172896
46replication fork processing (GO:0031297)3.26688362
47pseudouridine synthesis (GO:0001522)3.26591426
48protein-cofactor linkage (GO:0018065)3.22601721
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.16089745
50ATP biosynthetic process (GO:0006754)3.15719387
51rRNA processing (GO:0006364)3.15707821
52rRNA metabolic process (GO:0016072)3.09511677
53protein targeting to membrane (GO:0006612)3.06923952
54water-soluble vitamin biosynthetic process (GO:0042364)3.05225263
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04398944
56chromatin remodeling at centromere (GO:0031055)3.03037772
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.99979401
58purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99847182
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99080733
60hydrogen ion transmembrane transport (GO:1902600)2.98495899
61mRNA catabolic process (GO:0006402)2.96796938
62DNA replication checkpoint (GO:0000076)2.91916593
63negative regulation of T cell differentiation in thymus (GO:0033085)2.85718969
64L-fucose catabolic process (GO:0042355)2.84001955
65fucose catabolic process (GO:0019317)2.84001955
66L-fucose metabolic process (GO:0042354)2.84001955
67positive regulation of respiratory burst (GO:0060267)2.83788326
68negative regulation of appetite (GO:0032099)2.77505792
69negative regulation of response to food (GO:0032096)2.77505792
70respiratory chain complex IV assembly (GO:0008535)2.76811721
71RNA catabolic process (GO:0006401)2.76348364
72substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.71246363
73substrate-independent telencephalic tangential migration (GO:0021826)2.71246363
74proton transport (GO:0015992)2.70843475
75ribonucleoside triphosphate biosynthetic process (GO:0009201)2.69883570
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.68897123
77GTP biosynthetic process (GO:0006183)2.68550875
78negative regulation of telomere maintenance (GO:0032205)2.68361080
79cytochrome complex assembly (GO:0017004)2.68095496
80hydrogen transport (GO:0006818)2.64260996
81resolution of meiotic recombination intermediates (GO:0000712)2.61616713
82tRNA processing (GO:0008033)2.61236849
83CENP-A containing nucleosome assembly (GO:0034080)2.61156485
84maturation of 5.8S rRNA (GO:0000460)2.59298163
85ribosome biogenesis (GO:0042254)2.57064549
86protein polyglutamylation (GO:0018095)2.55232385
87intracellular protein transmembrane import (GO:0044743)2.54655526
88negative regulation of mast cell activation (GO:0033004)2.52767674
89epithelial cilium movement (GO:0003351)2.51941063
90positive regulation of T cell apoptotic process (GO:0070234)2.51653822
91RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.51119599
92cell proliferation in forebrain (GO:0021846)2.51070904
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50647291
94negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.47079461
95rRNA modification (GO:0000154)2.46588004
96establishment of protein localization to mitochondrion (GO:0072655)2.46461742
97regulation of response to food (GO:0032095)2.45930218
98phenol-containing compound catabolic process (GO:0019336)2.43583573
99ncRNA processing (GO:0034470)2.42426672
100protein targeting to mitochondrion (GO:0006626)2.42199087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.96882408
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58965467
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.58280527
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25749584
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19579620
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.18077235
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90734192
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66282222
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63833755
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63504817
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.60893422
12VDR_22108803_ChIP-Seq_LS180_Human2.42748856
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.29766010
14ZNF274_21170338_ChIP-Seq_K562_Hela2.10391800
15VDR_23849224_ChIP-Seq_CD4+_Human1.94815779
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90709758
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85813619
18MYC_18940864_ChIP-ChIP_HL60_Human1.80867331
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78132247
20FOXP3_21729870_ChIP-Seq_TREG_Human1.77004733
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76838481
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71157594
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66065552
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64263321
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63704717
26ELK1_19687146_ChIP-ChIP_HELA_Human1.63494021
27IRF1_19129219_ChIP-ChIP_H3396_Human1.62668347
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.57801821
29EWS_26573619_Chip-Seq_HEK293_Human1.54571441
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52976011
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.51593371
32TP53_22573176_ChIP-Seq_HFKS_Human1.51197281
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49919940
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47255515
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47133314
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46759736
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45078897
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44396261
39FUS_26573619_Chip-Seq_HEK293_Human1.44038311
40TTF2_22483619_ChIP-Seq_HELA_Human1.43507896
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36636062
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32629082
43REST_21632747_ChIP-Seq_MESCs_Mouse1.30950109
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.27428973
45XRN2_22483619_ChIP-Seq_HELA_Human1.27340048
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.25340155
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25172596
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25103473
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25024700
50GABP_19822575_ChIP-Seq_HepG2_Human1.24011170
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23798148
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21407096
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20926785
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19724687
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19659242
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19210681
57NCOR_22424771_ChIP-Seq_293T_Human1.18389541
58TAF2_19829295_ChIP-Seq_ESCs_Human1.17850786
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.17107698
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.15768301
61NANOG_20526341_ChIP-Seq_ESCs_Human1.14575645
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12936579
63IGF1R_20145208_ChIP-Seq_DFB_Human1.11291532
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10074136
65ERA_21632823_ChIP-Seq_H3396_Human1.09429300
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07519503
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07353956
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07245260
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.02371534
70TAF15_26573619_Chip-Seq_HEK293_Human1.02183280
71P300_19829295_ChIP-Seq_ESCs_Human0.99732229
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99365445
73ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99210092
74RNF2_27304074_Chip-Seq_NSC_Mouse0.99062198
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99016148
76POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98461230
77TP63_19390658_ChIP-ChIP_HaCaT_Human0.98459673
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98179957
79CIITA_25753668_ChIP-Seq_RAJI_Human0.97374182
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97221237
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.94554376
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94554376
83EED_16625203_ChIP-ChIP_MESCs_Mouse0.94347509
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94272006
85EZH2_27294783_Chip-Seq_ESCs_Mouse0.93861943
86REST_18959480_ChIP-ChIP_MESCs_Mouse0.93376764
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91943072
88AR_20517297_ChIP-Seq_VCAP_Human0.89128497
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88820642
90CBP_20019798_ChIP-Seq_JUKART_Human0.88820642
91P53_21459846_ChIP-Seq_SAOS-2_Human0.88688302
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87983043
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87275416
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87249880
95HTT_18923047_ChIP-ChIP_STHdh_Human0.86949942
96MYC_19829295_ChIP-Seq_ESCs_Human0.85160155
97HOXB7_26014856_ChIP-Seq_BT474_Human0.84694554
98SOX2_19829295_ChIP-Seq_ESCs_Human0.83140473
99NANOG_19829295_ChIP-Seq_ESCs_Human0.83140473
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.83093222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.62408244
2MP0006292_abnormal_olfactory_placode4.30627085
3MP0008877_abnormal_DNA_methylation2.85708462
4MP0003787_abnormal_imprinting2.77748798
5MP0006072_abnormal_retinal_apoptosis2.57863615
6MP0003122_maternal_imprinting2.08801583
7MP0003121_genomic_imprinting2.02002904
8MP0001968_abnormal_touch/_nociception1.97011869
9MP0001485_abnormal_pinna_reflex1.89953942
10MP0008789_abnormal_olfactory_epithelium1.85198945
11MP0004742_abnormal_vestibular_system1.78537286
12MP0005551_abnormal_eye_electrophysiolog1.78416305
13MP0002736_abnormal_nociception_after1.77606628
14MP0004885_abnormal_endolymph1.75420396
15MP0008872_abnormal_physiological_respon1.74255531
16MP0004147_increased_porphyrin_level1.66115849
17MP0002234_abnormal_pharynx_morphology1.64591908
18MP0003646_muscle_fatigue1.62307275
19MP0000049_abnormal_middle_ear1.59994189
20MP0005645_abnormal_hypothalamus_physiol1.59905676
21MP0001293_anophthalmia1.59794096
22MP0008875_abnormal_xenobiotic_pharmacok1.57618731
23MP0004142_abnormal_muscle_tone1.55965630
24MP0008057_abnormal_DNA_replication1.53715855
25MP0003123_paternal_imprinting1.49796305
26MP0009745_abnormal_behavioral_response1.48648492
27MP0000569_abnormal_digit_pigmentation1.47809614
28MP0002938_white_spotting1.46608464
29MP0003011_delayed_dark_adaptation1.45088639
30MP0003880_abnormal_central_pattern1.43217911
31MP0001905_abnormal_dopamine_level1.42983207
32MP0002272_abnormal_nervous_system1.42373380
33MP0002837_dystrophic_cardiac_calcinosis1.41314761
34MP0005394_taste/olfaction_phenotype1.40491568
35MP0005499_abnormal_olfactory_system1.40491568
36MP0002102_abnormal_ear_morphology1.40102077
37MP0002095_abnormal_skin_pigmentation1.39822478
38MP0005646_abnormal_pituitary_gland1.38692924
39MP0005253_abnormal_eye_physiology1.34742554
40MP0008058_abnormal_DNA_repair1.34197312
41MP0004145_abnormal_muscle_electrophysio1.33664712
42MP0002876_abnormal_thyroid_physiology1.32460518
43MP0000631_abnormal_neuroendocrine_gland1.31283428
44MP0003693_abnormal_embryo_hatching1.31114954
45MP0004133_heterotaxia1.28626377
46MP0002163_abnormal_gland_morphology1.28575375
47MP0005174_abnormal_tail_pigmentation1.27054433
48MP0001188_hyperpigmentation1.25547924
49MP0005377_hearing/vestibular/ear_phenot1.22583346
50MP0003878_abnormal_ear_physiology1.22583346
51MP0002733_abnormal_thermal_nociception1.22198155
52MP0003718_maternal_effect1.20857848
53MP0006276_abnormal_autonomic_nervous1.18404774
54MP0001486_abnormal_startle_reflex1.16200696
55MP0001440_abnormal_grooming_behavior1.13959866
56MP0003938_abnormal_ear_development1.12444793
57MP0005671_abnormal_response_to1.12137006
58MP0005389_reproductive_system_phenotype1.11871898
59MP0002160_abnormal_reproductive_system1.11232191
60MP0002064_seizures1.08389497
61MP0001970_abnormal_pain_threshold1.07354348
62MP0005195_abnormal_posterior_eye1.05075817
63MP0001919_abnormal_reproductive_system1.04195972
64MP0009046_muscle_twitch1.02398946
65MP0000026_abnormal_inner_ear1.01980963
66MP0005084_abnormal_gallbladder_morpholo1.01309838
67MP0000372_irregular_coat_pigmentation0.99868955
68MP0010094_abnormal_chromosome_stability0.99774629
69MP0006036_abnormal_mitochondrial_physio0.99756872
70MP0002752_abnormal_somatic_nervous0.99130539
71MP0001963_abnormal_hearing_physiology0.97771315
72MP0002557_abnormal_social/conspecific_i0.97452595
73MP0005423_abnormal_somatic_nervous0.97404261
74MP0001529_abnormal_vocalization0.95305360
75MP0002735_abnormal_chemical_nociception0.95012160
76MP0003283_abnormal_digestive_organ0.94472031
77MP0002653_abnormal_ependyma_morphology0.89913477
78MP0003937_abnormal_limbs/digits/tail_de0.89243127
79MP0002210_abnormal_sex_determination0.88704439
80MP0004043_abnormal_pH_regulation0.88231106
81MP0002184_abnormal_innervation0.87453483
82MP0003635_abnormal_synaptic_transmissio0.87399075
83MP0005636_abnormal_mineral_homeostasis0.86143570
84MP0005360_urolithiasis0.84848011
85MP0001984_abnormal_olfaction0.84697233
86MP0000778_abnormal_nervous_system0.84182279
87MP0003186_abnormal_redox_activity0.83794704
88MP0005391_vision/eye_phenotype0.79858681
89MP0002822_catalepsy0.79723992
90MP0001324_abnormal_eye_pigmentation0.75761219
91MP0002067_abnormal_sensory_capabilities0.75138267
92MP0002572_abnormal_emotion/affect_behav0.74647846
93MP0000955_abnormal_spinal_cord0.72991057
94MP0008995_early_reproductive_senescence0.72543000
95MP0002063_abnormal_learning/memory/cond0.70102414
96MP0002277_abnormal_respiratory_mucosa0.67801545
97MP0001765_abnormal_ion_homeostasis0.66883913
98MP0005379_endocrine/exocrine_gland_phen0.66097471
99MP0002233_abnormal_nose_morphology0.64987335
100MP0001929_abnormal_gametogenesis0.63846421

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.27294890
2Acute necrotizing encephalopathy (HP:0006965)4.25738175
3Acute encephalopathy (HP:0006846)3.81443142
4Mitochondrial inheritance (HP:0001427)3.77886713
5Abnormal mitochondria in muscle tissue (HP:0008316)3.73127816
6Increased hepatocellular lipid droplets (HP:0006565)3.58465735
7Abnormality of cells of the erythroid lineage (HP:0012130)3.55833475
8Progressive macrocephaly (HP:0004481)3.45278152
9Abnormality of midbrain morphology (HP:0002418)3.35040115
10Molar tooth sign on MRI (HP:0002419)3.35040115
11Increased CSF lactate (HP:0002490)3.33815362
12Lipid accumulation in hepatocytes (HP:0006561)3.30232670
13Pancreatic fibrosis (HP:0100732)3.30075544
14Pancreatic cysts (HP:0001737)3.16464741
15Macrocytic anemia (HP:0001972)3.12069694
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06492752
17Abnormal number of erythroid precursors (HP:0012131)2.97090797
18Pendular nystagmus (HP:0012043)2.85495019
19Renal Fanconi syndrome (HP:0001994)2.85373914
20Hepatocellular necrosis (HP:0001404)2.82386405
21Congenital stationary night blindness (HP:0007642)2.77391195
22Aplasia/Hypoplasia of the sacrum (HP:0008517)2.71630445
23Cerebral edema (HP:0002181)2.66328173
24Abnormal drinking behavior (HP:0030082)2.65468690
25Polydipsia (HP:0001959)2.65468690
26Increased intramyocellular lipid droplets (HP:0012240)2.65291968
27Nephronophthisis (HP:0000090)2.60701651
283-Methylglutaconic aciduria (HP:0003535)2.56884989
29True hermaphroditism (HP:0010459)2.54633372
30Colon cancer (HP:0003003)2.53185007
31Volvulus (HP:0002580)2.46367759
32Absent thumb (HP:0009777)2.46186882
33Optic disc pallor (HP:0000543)2.43798692
34Pallor (HP:0000980)2.43120554
35Hepatic necrosis (HP:0002605)2.42966332
36Abnormality of the renal cortex (HP:0011035)2.39616255
37Tubular atrophy (HP:0000092)2.35558704
38Asplenia (HP:0001746)2.35383885
39Hyperglycinemia (HP:0002154)2.35012276
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.34044076
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33796985
42Abnormality of the renal medulla (HP:0100957)2.33633629
43Congenital, generalized hypertrichosis (HP:0004540)2.33302422
44Type II lissencephaly (HP:0007260)2.32513561
45Increased serum lactate (HP:0002151)2.32138281
46Rib fusion (HP:0000902)2.30949561
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30620898
48Cystic liver disease (HP:0006706)2.24277531
49Exertional dyspnea (HP:0002875)2.24244419
50Abnormal rod and cone electroretinograms (HP:0008323)2.20628868
51Abnormality of the labia minora (HP:0012880)2.20357680
52Septo-optic dysplasia (HP:0100842)2.16986320
53Increased muscle lipid content (HP:0009058)2.14085348
54Polyuria (HP:0000103)2.13986866
55Lactic acidosis (HP:0003128)2.13814860
56Medial flaring of the eyebrow (HP:0010747)2.11165495
57Chromsome breakage (HP:0040012)2.07236579
58Leukodystrophy (HP:0002415)2.06909667
59Ectopic kidney (HP:0000086)2.06744325
60Sclerocornea (HP:0000647)2.06589594
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03060523
62Abnormal biliary tract physiology (HP:0012439)2.01595891
63Bile duct proliferation (HP:0001408)2.01595891
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01156900
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01156900
66Abnormality of renal resorption (HP:0011038)2.00684158
67Respiratory difficulties (HP:0002880)1.99870641
68Supernumerary spleens (HP:0009799)1.97346117
69Glycosuria (HP:0003076)1.95375894
70Abnormality of urine glucose concentration (HP:0011016)1.95375894
71Cleft eyelid (HP:0000625)1.91074247
72Hypoplasia of the pons (HP:0012110)1.90195458
73Lethargy (HP:0001254)1.89619958
74Pancytopenia (HP:0001876)1.89018279
75Hypoplasia of the radius (HP:0002984)1.88559525
76Abnormality of the phalanges of the 5th finger (HP:0004213)1.87905164
77Chronic hepatic failure (HP:0100626)1.85795909
78Abnormality of the pons (HP:0007361)1.85466719
79Abnormality of the renal collecting system (HP:0004742)1.85220499
80Hyperphosphaturia (HP:0003109)1.83955943
81Exercise intolerance (HP:0003546)1.83395301
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.80592177
83Abolished electroretinogram (ERG) (HP:0000550)1.79859589
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78578996
85Abnormal ciliary motility (HP:0012262)1.77166228
86Stenosis of the external auditory canal (HP:0000402)1.76295080
87Myokymia (HP:0002411)1.75883413
88Decreased central vision (HP:0007663)1.75865769
89Oligodactyly (hands) (HP:0001180)1.75482960
90Optic nerve hypoplasia (HP:0000609)1.75441093
91Abnormality of magnesium homeostasis (HP:0004921)1.75301673
92Abnormal urine output (HP:0012590)1.74721034
93Aplastic anemia (HP:0001915)1.74002341
94Triphalangeal thumb (HP:0001199)1.73999425
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73969508
96Abnormality of the ileum (HP:0001549)1.73919041
97Methylmalonic aciduria (HP:0012120)1.73308094
98Congenital hepatic fibrosis (HP:0002612)1.72986100
99Anencephaly (HP:0002323)1.72951075
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71663882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.19519901
2STK162.99889550
3CDC72.76531970
4WNK42.75371724
5TLK12.66995105
6VRK22.37002922
7TRIM282.32387972
8ADRBK22.22205442
9PINK12.02894227
10MST42.01792319
11CDK192.01268371
12NUAK12.01122761
13GRK11.93195764
14DYRK21.77033641
15BUB11.75409362
16FLT31.59669157
17MAP4K21.59070154
18STK391.58590808
19TNIK1.50259192
20BMPR1B1.49568386
21PIK3CA1.46114647
22TXK1.42131561
23CASK1.40850835
24KIT1.39845939
25PNCK1.38462855
26OXSR11.36634515
27TIE11.36080434
28FRK1.34973696
29VRK11.29963372
30MAP2K71.29353677
31BCKDK1.28801280
32PAK31.23923072
33KDR1.22519540
34WNK31.18765731
35CDK81.17560797
36NME11.16075757
37PRKCG1.11739110
38EPHB21.11159590
39MAP3K41.10534335
40PLK41.08406162
41TAF11.08001895
42MKNK21.01081028
43INSRR0.98905145
44ATR0.95832577
45AURKA0.93981247
46PLK30.93780205
47AURKB0.90396644
48CSNK1E0.89641192
49PLK10.89207946
50NME20.86939112
51PASK0.86592071
52CAMK10.83761393
53PRKCQ0.81573219
54SRPK10.79723813
55LIMK10.79171001
56ADRBK10.78750404
57CSNK2A20.78578211
58MAPK130.76169606
59PRKCI0.70247539
60EPHA40.69462546
61NTRK30.69442317
62BRSK10.66329358
63MINK10.65799581
64DYRK30.62715825
65NEK20.61879484
66WEE10.61567969
67TNK20.60751513
68PLK20.60296688
69PRKACA0.59865571
70CSNK2A10.57338066
71STK110.55497363
72CHEK10.54999603
73TEC0.54346869
74CHEK20.52278642
75PRKCA0.51753579
76MAP3K110.50445645
77DAPK30.48840750
78ATM0.47723152
79CCNB10.45784029
80ACVR1B0.45384215
81CAMK2A0.45206420
82LRRK20.44906651
83TAOK30.44628093
84MKNK10.44448535
85MAPKAPK30.41981550
86PRKDC0.41066355
87CSNK1A10.40999473
88GRK50.40769630
89WNK10.40172921
90ABL20.40148389
91PRKCH0.38788482
92CSF1R0.38286165
93PRKG10.36564530
94DAPK10.36409254
95MAP2K40.35818215
96MAPKAPK50.33791208
97CSNK1G20.33575622
98TGFBR10.33170128
99NTRK20.33164359
100FES0.33087368

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.14267108
2Oxidative phosphorylation_Homo sapiens_hsa001904.11657314
3Parkinsons disease_Homo sapiens_hsa050123.39195590
4RNA polymerase_Homo sapiens_hsa030202.57637533
5Proteasome_Homo sapiens_hsa030502.45567515
6Huntingtons disease_Homo sapiens_hsa050162.37238457
7Alzheimers disease_Homo sapiens_hsa050102.22026869
8Cardiac muscle contraction_Homo sapiens_hsa042602.19501638
9Protein export_Homo sapiens_hsa030602.17779481
10Sulfur relay system_Homo sapiens_hsa041222.13483158
11DNA replication_Homo sapiens_hsa030302.06328070
12Homologous recombination_Homo sapiens_hsa034402.05575904
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03976892
14Caffeine metabolism_Homo sapiens_hsa002321.96453294
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93750013
16Mismatch repair_Homo sapiens_hsa034301.88592181
17Linoleic acid metabolism_Homo sapiens_hsa005911.83182794
18Fanconi anemia pathway_Homo sapiens_hsa034601.72193727
19Phototransduction_Homo sapiens_hsa047441.62210110
20RNA degradation_Homo sapiens_hsa030181.52753296
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49918523
22Basal transcription factors_Homo sapiens_hsa030221.48233031
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47876769
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47240146
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44813979
26One carbon pool by folate_Homo sapiens_hsa006701.38817988
27Pyrimidine metabolism_Homo sapiens_hsa002401.37469858
28Asthma_Homo sapiens_hsa053101.34542572
29Nicotine addiction_Homo sapiens_hsa050331.33493044
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19790533
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18656629
32Spliceosome_Homo sapiens_hsa030401.16293594
33Fat digestion and absorption_Homo sapiens_hsa049751.16244949
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16002229
35Nucleotide excision repair_Homo sapiens_hsa034201.15183249
36Folate biosynthesis_Homo sapiens_hsa007901.13839095
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.11393686
38Olfactory transduction_Homo sapiens_hsa047401.11255655
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08862605
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.06334150
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01229829
42RNA transport_Homo sapiens_hsa030131.01097064
43Allograft rejection_Homo sapiens_hsa053300.99346690
44Primary immunodeficiency_Homo sapiens_hsa053400.97262523
45Base excision repair_Homo sapiens_hsa034100.96791679
46Arachidonic acid metabolism_Homo sapiens_hsa005900.94630484
47Autoimmune thyroid disease_Homo sapiens_hsa053200.94599193
48Purine metabolism_Homo sapiens_hsa002300.91943521
49Type I diabetes mellitus_Homo sapiens_hsa049400.88066312
50Tryptophan metabolism_Homo sapiens_hsa003800.86148240
51Chemical carcinogenesis_Homo sapiens_hsa052040.86004633
52Graft-versus-host disease_Homo sapiens_hsa053320.85258480
53Regulation of autophagy_Homo sapiens_hsa041400.84476467
54Non-homologous end-joining_Homo sapiens_hsa034500.81265272
55Retinol metabolism_Homo sapiens_hsa008300.77460649
56Propanoate metabolism_Homo sapiens_hsa006400.77449120
57Peroxisome_Homo sapiens_hsa041460.76948235
58Morphine addiction_Homo sapiens_hsa050320.74090574
59Ether lipid metabolism_Homo sapiens_hsa005650.73660164
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71681245
61Collecting duct acid secretion_Homo sapiens_hsa049660.71151068
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.70780261
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69579148
64Butanoate metabolism_Homo sapiens_hsa006500.69101376
65Sulfur metabolism_Homo sapiens_hsa009200.67017512
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66585682
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66412234
68Glutathione metabolism_Homo sapiens_hsa004800.66057027
69Metabolic pathways_Homo sapiens_hsa011000.65296666
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.60947258
71Nitrogen metabolism_Homo sapiens_hsa009100.60733994
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59445723
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57861802
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57674215
75Taste transduction_Homo sapiens_hsa047420.56135957
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56124218
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50339361
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.50117672
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.46233149
80Vitamin digestion and absorption_Homo sapiens_hsa049770.45422897
81Serotonergic synapse_Homo sapiens_hsa047260.42954626
82Insulin secretion_Homo sapiens_hsa049110.42798615
83Selenocompound metabolism_Homo sapiens_hsa004500.42331549
84Mineral absorption_Homo sapiens_hsa049780.42303926
85Arginine and proline metabolism_Homo sapiens_hsa003300.40966918
86Hedgehog signaling pathway_Homo sapiens_hsa043400.39433780
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39208618
88GABAergic synapse_Homo sapiens_hsa047270.38658930
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36917958
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36706429
91Hematopoietic cell lineage_Homo sapiens_hsa046400.35163590
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34427139
93Rheumatoid arthritis_Homo sapiens_hsa053230.33625838
94Basal cell carcinoma_Homo sapiens_hsa052170.33464641
95Antigen processing and presentation_Homo sapiens_hsa046120.31023035
96Glycerolipid metabolism_Homo sapiens_hsa005610.29975183
97beta-Alanine metabolism_Homo sapiens_hsa004100.29562458
98Circadian entrainment_Homo sapiens_hsa047130.29362556
99Glutamatergic synapse_Homo sapiens_hsa047240.27883585
100Salivary secretion_Homo sapiens_hsa049700.25591055

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