PTMAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)5.45317856
2ATP synthesis coupled proton transport (GO:0015986)5.45317856
3DNA deamination (GO:0045006)5.05924620
4behavioral response to nicotine (GO:0035095)4.98726437
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62359752
6ribosomal small subunit assembly (GO:0000028)4.61609544
7protein neddylation (GO:0045116)4.26310599
8negative regulation of mast cell activation (GO:0033004)4.15375302
9viral transcription (GO:0019083)3.99319183
10chaperone-mediated protein transport (GO:0072321)3.97623169
11translational termination (GO:0006415)3.92639084
12water-soluble vitamin biosynthetic process (GO:0042364)3.91283505
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81385983
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.64959132
15GTP biosynthetic process (GO:0006183)3.63914203
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63406681
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.54866130
18NADH dehydrogenase complex assembly (GO:0010257)3.54866130
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54866130
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53563427
21electron transport chain (GO:0022900)3.51192074
22ribosomal small subunit biogenesis (GO:0042274)3.51169121
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50779168
24respiratory electron transport chain (GO:0022904)3.49622308
25maturation of SSU-rRNA (GO:0030490)3.49432556
26translational elongation (GO:0006414)3.45379623
27termination of RNA polymerase III transcription (GO:0006386)3.45072683
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.45072683
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44646207
30protein targeting to ER (GO:0045047)3.42147048
31cotranslational protein targeting to membrane (GO:0006613)3.42065985
32protein complex biogenesis (GO:0070271)3.41768987
33regulation of chronic inflammatory response (GO:0002676)3.36466253
34pseudouridine synthesis (GO:0001522)3.35532125
35cytidine deamination (GO:0009972)3.30258742
36cytidine metabolic process (GO:0046087)3.30258742
37cytidine catabolic process (GO:0006216)3.30258742
38ribosomal large subunit biogenesis (GO:0042273)3.26078591
39protein localization to endoplasmic reticulum (GO:0070972)3.24793077
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24344485
41mitochondrial respiratory chain complex assembly (GO:0033108)3.17011140
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14227198
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14227198
44negative regulation of telomere maintenance (GO:0032205)3.13539233
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.12995689
46rRNA modification (GO:0000154)3.12140270
47translation (GO:0006412)3.12026943
48purine nucleoside triphosphate biosynthetic process (GO:0009145)3.11129057
49peptidyl-histidine modification (GO:0018202)3.05972731
50positive regulation of prostaglandin secretion (GO:0032308)3.02094155
51positive regulation of fatty acid transport (GO:2000193)3.00124123
52cellular component biogenesis (GO:0044085)2.98883638
53viral life cycle (GO:0019058)2.98419084
54rRNA processing (GO:0006364)2.97489982
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97068683
56ATP biosynthetic process (GO:0006754)2.96916159
57UTP biosynthetic process (GO:0006228)2.96074321
58negative regulation of T cell differentiation in thymus (GO:0033085)2.93674671
59ribonucleoprotein complex biogenesis (GO:0022613)2.93548018
60rRNA metabolic process (GO:0016072)2.92771729
61base-excision repair, AP site formation (GO:0006285)2.92482102
62regulation of isotype switching to IgG isotypes (GO:0048302)2.92010463
63pyrimidine ribonucleoside catabolic process (GO:0046133)2.91534350
64kynurenine metabolic process (GO:0070189)2.88804964
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88544727
66cellular protein complex disassembly (GO:0043624)2.87075950
67maturation of 5.8S rRNA (GO:0000460)2.86290741
68replication fork processing (GO:0031297)2.85922848
69positive regulation of defense response to virus by host (GO:0002230)2.84346510
70protein-cofactor linkage (GO:0018065)2.83678457
71protein polyglutamylation (GO:0018095)2.83651402
72tRNA processing (GO:0008033)2.80194189
73UTP metabolic process (GO:0046051)2.79847498
74translational initiation (GO:0006413)2.79528674
75regulation of cellular amino acid metabolic process (GO:0006521)2.79238217
76positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.76502233
77cell proliferation in forebrain (GO:0021846)2.73752266
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72288004
79proteasome assembly (GO:0043248)2.71971236
80response to pheromone (GO:0019236)2.71924164
81hydrogen ion transmembrane transport (GO:1902600)2.71336015
82preassembly of GPI anchor in ER membrane (GO:0016254)2.70361757
83positive regulation of T cell apoptotic process (GO:0070234)2.69424207
84endoderm formation (GO:0001706)2.69210017
85negative regulation of DNA-dependent DNA replication (GO:2000104)2.69126053
86fucose catabolic process (GO:0019317)2.67747511
87L-fucose metabolic process (GO:0042354)2.67747511
88L-fucose catabolic process (GO:0042355)2.67747511
89piRNA metabolic process (GO:0034587)2.67269131
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67231471
91ribosome biogenesis (GO:0042254)2.65940871
92positive regulation of icosanoid secretion (GO:0032305)2.64518559
93regulation of immunoglobulin secretion (GO:0051023)2.64039068
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63558743
95proton transport (GO:0015992)2.57338523
96regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.56646667
97regulation of activation of Janus kinase activity (GO:0010533)2.54746079
98pyrimidine nucleotide catabolic process (GO:0006244)2.50152515
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49643222
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.49525696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19209663
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.83975876
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76680054
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.34409648
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30920252
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.24660697
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11657428
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09192610
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76215825
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76075042
11VDR_22108803_ChIP-Seq_LS180_Human2.73057155
12ZNF274_21170338_ChIP-Seq_K562_Hela2.66365019
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.62687550
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59019338
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54812368
16VDR_23849224_ChIP-Seq_CD4+_Human2.18582451
17IGF1R_20145208_ChIP-Seq_DFB_Human1.93000642
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.92892508
19ELK1_19687146_ChIP-ChIP_HELA_Human1.90276076
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85412210
21FOXP3_21729870_ChIP-Seq_TREG_Human1.81666943
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.81294906
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77259136
24MYC_18940864_ChIP-ChIP_HL60_Human1.72708635
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66148899
26IRF1_19129219_ChIP-ChIP_H3396_Human1.62856776
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59833302
28EWS_26573619_Chip-Seq_HEK293_Human1.56371317
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.50529820
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49355883
31TP53_22573176_ChIP-Seq_HFKS_Human1.45910015
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.44578378
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40849072
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40780352
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40373385
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34971264
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.32782990
38NCOR_22424771_ChIP-Seq_293T_Human1.32601207
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31706732
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.31065458
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30870846
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28256863
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28062603
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27163095
45TTF2_22483619_ChIP-Seq_HELA_Human1.26506150
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25488347
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23122339
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.21528312
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21169284
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19770081
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18011674
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.18011674
53GABP_19822575_ChIP-Seq_HepG2_Human1.18005219
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15757864
55ERA_21632823_ChIP-Seq_H3396_Human1.14981269
56XRN2_22483619_ChIP-Seq_HELA_Human1.11928463
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11554885
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09942077
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08933016
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07182828
61TAF2_19829295_ChIP-Seq_ESCs_Human1.06397589
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06153724
63FUS_26573619_Chip-Seq_HEK293_Human1.05710444
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05468164
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04272000
66NANOG_20526341_ChIP-Seq_ESCs_Human1.02620178
67HOXB7_26014856_ChIP-Seq_BT474_Human1.02471614
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01986419
69P300_19829295_ChIP-Seq_ESCs_Human1.01602849
70MYC_19829295_ChIP-Seq_ESCs_Human1.01470622
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00464725
72MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99435849
73AR_20517297_ChIP-Seq_VCAP_Human0.97645229
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97562036
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97207464
76ER_23166858_ChIP-Seq_MCF-7_Human0.96918581
77EZH2_27304074_Chip-Seq_ESCs_Mouse0.96311236
78REST_21632747_ChIP-Seq_MESCs_Mouse0.96307030
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.96187185
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95700577
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95373021
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94959761
83CIITA_25753668_ChIP-Seq_RAJI_Human0.94596232
84CBX2_27304074_Chip-Seq_ESCs_Mouse0.92565410
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91850383
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91742759
87GATA3_26560356_Chip-Seq_TH2_Human0.90359573
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89346460
89NANOG_19829295_ChIP-Seq_ESCs_Human0.88953689
90SOX2_19829295_ChIP-Seq_ESCs_Human0.88953689
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.88148066
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87545964
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86639580
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.86458811
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86286216
96P53_21459846_ChIP-Seq_SAOS-2_Human0.85950680
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85591794
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85343126
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84893813
100CBP_20019798_ChIP-Seq_JUKART_Human0.84893813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.62476031
2MP0008877_abnormal_DNA_methylation2.88954755
3MP0003646_muscle_fatigue2.63055810
4MP0009379_abnormal_foot_pigmentation2.57336208
5MP0003787_abnormal_imprinting2.42804974
6MP0005671_abnormal_response_to2.39158592
7MP0006072_abnormal_retinal_apoptosis2.18895195
8MP0002102_abnormal_ear_morphology2.17531187
9MP0005646_abnormal_pituitary_gland2.14047602
10MP0008875_abnormal_xenobiotic_pharmacok2.09879941
11MP0008872_abnormal_physiological_respon2.05806483
12MP0001968_abnormal_touch/_nociception2.00395461
13MP0002138_abnormal_hepatobiliary_system1.97252659
14MP0004885_abnormal_endolymph1.91167806
15MP0001835_abnormal_antigen_presentation1.90900405
16MP0004145_abnormal_muscle_electrophysio1.87700485
17MP0008789_abnormal_olfactory_epithelium1.86344848
18MP0004147_increased_porphyrin_level1.84157971
19MP0000685_abnormal_immune_system1.80700634
20MP0002736_abnormal_nociception_after1.78154364
21MP0002876_abnormal_thyroid_physiology1.76078294
22MP0005551_abnormal_eye_electrophysiolog1.67097857
23MP0001293_anophthalmia1.59213036
24MP0005645_abnormal_hypothalamus_physiol1.58981543
25MP0005084_abnormal_gallbladder_morpholo1.51202899
26MP0005389_reproductive_system_phenotype1.51175756
27MP0001919_abnormal_reproductive_system1.49239147
28MP0001873_stomach_inflammation1.43035637
29MP0005253_abnormal_eye_physiology1.42680749
30MP0001485_abnormal_pinna_reflex1.42512578
31MP0006276_abnormal_autonomic_nervous1.39148089
32MP0003195_calcinosis1.38264260
33MP0001348_abnormal_lacrimal_gland1.38095240
34MP0004742_abnormal_vestibular_system1.37809773
35MP0002272_abnormal_nervous_system1.35992876
36MP0002160_abnormal_reproductive_system1.35863394
37MP0003786_premature_aging1.34342291
38MP0004142_abnormal_muscle_tone1.33167035
39MP0002653_abnormal_ependyma_morphology1.32182465
40MP0001905_abnormal_dopamine_level1.30270040
41MP0000372_irregular_coat_pigmentation1.28069249
42MP0003011_delayed_dark_adaptation1.27149425
43MP0001986_abnormal_taste_sensitivity1.25574828
44MP0000631_abnormal_neuroendocrine_gland1.23044895
45MP0005394_taste/olfaction_phenotype1.22184167
46MP0005499_abnormal_olfactory_system1.22184167
47MP0003693_abnormal_embryo_hatching1.21148295
48MP0002733_abnormal_thermal_nociception1.20897574
49MP0000049_abnormal_middle_ear1.20814953
50MP0009745_abnormal_behavioral_response1.20481910
51MP0005377_hearing/vestibular/ear_phenot1.20090310
52MP0003878_abnormal_ear_physiology1.20090310
53MP0003123_paternal_imprinting1.20028802
54MP0003121_genomic_imprinting1.19535916
55MP0003718_maternal_effect1.16469790
56MP0002163_abnormal_gland_morphology1.14742321
57MP0008058_abnormal_DNA_repair1.09984838
58MP0001800_abnormal_humoral_immune1.09944877
59MP0002938_white_spotting1.09400470
60MP0003880_abnormal_central_pattern1.08379630
61MP0002095_abnormal_skin_pigmentation1.07638782
62MP0001970_abnormal_pain_threshold1.03071476
63MP0002148_abnormal_hypersensitivity_rea1.02734683
64MP0000569_abnormal_digit_pigmentation1.01196818
65MP0005387_immune_system_phenotype0.99961973
66MP0001790_abnormal_immune_system0.99961973
67MP0005195_abnormal_posterior_eye0.97437097
68MP0002210_abnormal_sex_determination0.97199450
69MP0002557_abnormal_social/conspecific_i0.94133988
70MP0010094_abnormal_chromosome_stability0.93734426
71MP0002638_abnormal_pupillary_reflex0.92951747
72MP0002277_abnormal_respiratory_mucosa0.92371355
73MP0004133_heterotaxia0.91795214
74MP0002837_dystrophic_cardiac_calcinosis0.91546481
75MP0003186_abnormal_redox_activity0.88689618
76MP0002752_abnormal_somatic_nervous0.85614435
77MP0009764_decreased_sensitivity_to0.83781510
78MP0000778_abnormal_nervous_system0.82921795
79MP0006036_abnormal_mitochondrial_physio0.82865371
80MP0001440_abnormal_grooming_behavior0.82226345
81MP0002184_abnormal_innervation0.81121923
82MP0001501_abnormal_sleep_pattern0.81034346
83MP0002572_abnormal_emotion/affect_behav0.80811148
84MP0004043_abnormal_pH_regulation0.80696303
85MP0010030_abnormal_orbit_morphology0.80644909
86MP0008995_early_reproductive_senescence0.80343294
87MP0001502_abnormal_circadian_rhythm0.80182070
88MP0002067_abnormal_sensory_capabilities0.79435959
89MP0003122_maternal_imprinting0.79398437
90MP0002063_abnormal_learning/memory/cond0.78992490
91MP0003936_abnormal_reproductive_system0.78020653
92MP0008775_abnormal_heart_ventricle0.77638945
93MP0005083_abnormal_biliary_tract0.77533485
94MP0005075_abnormal_melanosome_morpholog0.76356158
95MP0002254_reproductive_system_inflammat0.76312892
96MP0003866_abnormal_defecation0.76193796
97MP0001486_abnormal_startle_reflex0.75545496
98MP0003938_abnormal_ear_development0.75319156
99MP0002723_abnormal_immune_serum0.74981212
100MP0001119_abnormal_female_reproductive0.73925863

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.17625792
2Acute necrotizing encephalopathy (HP:0006965)3.81450118
3Pancreatic cysts (HP:0001737)3.67034990
4Mitochondrial inheritance (HP:0001427)3.48633448
5Abnormality of midbrain morphology (HP:0002418)3.43612315
6Molar tooth sign on MRI (HP:0002419)3.43612315
7Acute encephalopathy (HP:0006846)3.41198426
83-Methylglutaconic aciduria (HP:0003535)3.37485428
9Abnormal mitochondria in muscle tissue (HP:0008316)3.35268929
10Increased CSF lactate (HP:0002490)3.34295021
11Pancreatic fibrosis (HP:0100732)3.31965640
12Asplenia (HP:0001746)3.18188144
13Aplasia/Hypoplasia of the spleen (HP:0010451)3.14899934
14Nephronophthisis (HP:0000090)3.07913076
15Progressive macrocephaly (HP:0004481)3.05333828
16Increased hepatocellular lipid droplets (HP:0006565)2.97792539
17Abnormality of the renal cortex (HP:0011035)2.97422772
18Reticulocytopenia (HP:0001896)2.96646413
19Pendular nystagmus (HP:0012043)2.91877696
20Lipid accumulation in hepatocytes (HP:0006561)2.82409842
21True hermaphroditism (HP:0010459)2.77891406
22Decreased central vision (HP:0007663)2.75709021
23Abnormality of the renal medulla (HP:0100957)2.74502101
24IgG deficiency (HP:0004315)2.73513288
25Colon cancer (HP:0003003)2.67464083
26Methylmalonic acidemia (HP:0002912)2.65004222
27Optic disc pallor (HP:0000543)2.61055591
28Prostate neoplasm (HP:0100787)2.58567941
29Abnormal drinking behavior (HP:0030082)2.56340078
30Polydipsia (HP:0001959)2.56340078
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55158818
32Hepatocellular necrosis (HP:0001404)2.52882264
33Abnormality of cells of the erythroid lineage (HP:0012130)2.52672768
34Increased serum lactate (HP:0002151)2.51392219
35Stomatitis (HP:0010280)2.48517551
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46306049
37Testicular atrophy (HP:0000029)2.46088230
38Abnormal rod and cone electroretinograms (HP:0008323)2.45116849
39Renal Fanconi syndrome (HP:0001994)2.39524446
40Increased intramyocellular lipid droplets (HP:0012240)2.39352445
41Congenital, generalized hypertrichosis (HP:0004540)2.37386132
42Supernumerary spleens (HP:0009799)2.37320729
43Type II lissencephaly (HP:0007260)2.32377816
44Absent thumb (HP:0009777)2.31900550
45Bile duct proliferation (HP:0001408)2.30593918
46Abnormal biliary tract physiology (HP:0012439)2.30593918
47Cerebral edema (HP:0002181)2.26778353
48Septo-optic dysplasia (HP:0100842)2.26745500
49Abolished electroretinogram (ERG) (HP:0000550)2.25789278
50Methylmalonic aciduria (HP:0012120)2.21769343
51Abnormal number of erythroid precursors (HP:0012131)2.21676354
52Chronic hepatic failure (HP:0100626)2.21518504
53Hepatic necrosis (HP:0002605)2.20817079
54Elevated erythrocyte sedimentation rate (HP:0003565)2.20482429
55Abnormality of the labia minora (HP:0012880)2.19856365
56Macrocytic anemia (HP:0001972)2.16750396
57Hyperglycinemia (HP:0002154)2.15257748
58Tubular atrophy (HP:0000092)2.14942596
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11270458
60Polyuria (HP:0000103)2.09149338
61Sclerocornea (HP:0000647)2.04264836
62Renal cortical cysts (HP:0000803)2.01962731
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01646947
64Dyschromatopsia (HP:0007641)2.00955725
65Cystic liver disease (HP:0006706)1.99874928
66Oligodactyly (hands) (HP:0001180)1.98237344
67Exertional dyspnea (HP:0002875)1.96604771
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94893170
69Abnormality of alanine metabolism (HP:0010916)1.94893170
70Hyperalaninemia (HP:0003348)1.94893170
71Pancytopenia (HP:0001876)1.94378347
72Attenuation of retinal blood vessels (HP:0007843)1.93964835
73Increased muscle lipid content (HP:0009058)1.92802543
74Congenital hepatic fibrosis (HP:0002612)1.91917849
75Lactic acidosis (HP:0003128)1.90842653
76Adrenal hypoplasia (HP:0000835)1.89467000
77Severe visual impairment (HP:0001141)1.89367912
78Increased IgM level (HP:0003496)1.86769530
79Lethargy (HP:0001254)1.82080062
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81504534
81Anencephaly (HP:0002323)1.80952453
82Optic nerve hypoplasia (HP:0000609)1.79921146
83Abnormality of the ileum (HP:0001549)1.74971067
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.74744130
85Absent/shortened dynein arms (HP:0200106)1.74744130
86Aplasia/hypoplasia of the uterus (HP:0008684)1.73820297
87Exercise intolerance (HP:0003546)1.73415887
88Hypoplasia of the ulna (HP:0003022)1.71917611
89Meckel diverticulum (HP:0002245)1.71308888
90Male pseudohermaphroditism (HP:0000037)1.67945734
91Abnormal respiratory motile cilium morphology (HP:0005938)1.66389475
92Abnormal respiratory epithelium morphology (HP:0012253)1.66389475
93Leukodystrophy (HP:0002415)1.66197958
94Aplasia/Hypoplasia of the ulna (HP:0006495)1.65233895
95Medial flaring of the eyebrow (HP:0010747)1.64580431
96Abnormal urine output (HP:0012590)1.64493912
97Respiratory difficulties (HP:0002880)1.64071654
98Pallor (HP:0000980)1.63380399
99Abnormality of the prostate (HP:0008775)1.62830985
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.62701083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.56349474
2TXK3.00547575
3GRK12.95199643
4VRK22.84694228
5ADRBK22.69586284
6ZAK2.67661373
7NUAK12.66260384
8TAOK32.58248271
9TIE12.14608848
10LIMK11.99667173
11TESK21.87935373
12MST41.81585375
13BCKDK1.71543983
14SRPK11.66722090
15CDC71.64697663
16TSSK61.64251829
17DYRK21.62601419
18WNK31.55908341
19FRK1.52563269
20TLK11.51831309
21MAP4K11.49299170
22STK161.48674625
23STK391.40439245
24CAMKK21.38348815
25VRK11.37035062
26MAP4K21.32118228
27MAP3K111.25659892
28NME11.24533989
29NME21.23963772
30FES1.21598605
31BMPR1B1.20554298
32NEK11.18794937
33BUB11.18074706
34OXSR11.17378911
35TAF11.09942366
36GRK51.06397599
37PINK11.01086002
38KDR1.00714689
39PLK30.99286989
40PHKG20.98503662
41PHKG10.98503662
42IKBKB0.96864484
43TNIK0.93068307
44MAPK130.90944087
45PLK20.87025257
46EIF2AK30.83797767
47PIK3CA0.83584637
48PLK40.82651508
49INSRR0.82355361
50CDK80.80651619
51TEC0.77974214
52CSNK1G30.77317446
53AURKA0.76427251
54CSNK1G20.76383482
55ATR0.75028083
56MAP2K20.74956755
57CAMKK10.74169308
58ADRBK10.73941701
59PRKCQ0.73316601
60EIF2AK20.71932699
61PDK20.71056897
62PRKCG0.69643118
63PLK10.69175027
64BRSK10.68480781
65ITK0.67977557
66CSNK1A1L0.67613116
67EIF2AK10.66222880
68EPHB20.65950018
69AURKB0.65487173
70RPS6KA50.65485851
71CSNK2A20.64661412
72TRIM280.63991205
73CSNK1G10.63694105
74MAPKAPK30.62167500
75NTRK20.58043400
76MAPKAPK50.57535016
77SYK0.57018614
78DAPK10.55692321
79WNK10.54807108
80PRKCI0.52866862
81CSNK2A10.52423826
82ABL20.50889035
83PRKACA0.50531861
84PBK0.49249068
85NEK20.49176124
86PAK30.47050948
87BTK0.46858410
88TYRO30.44916895
89OBSCN0.44553651
90CSNK1E0.44262041
91KIT0.42857863
92CSNK1A10.42627174
93DAPK20.40438600
94CAMK10.39397292
95CASK0.37919440
96CDK190.36931562
97CHEK20.35929449
98PRKCE0.35615381
99LCK0.35142994
100MAP2K70.34516806

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.99130363
2Proteasome_Homo sapiens_hsa030503.67983106
3Oxidative phosphorylation_Homo sapiens_hsa001903.54307040
4Parkinsons disease_Homo sapiens_hsa050123.15062033
5RNA polymerase_Homo sapiens_hsa030202.68360421
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49272194
7Asthma_Homo sapiens_hsa053102.43084266
8Allograft rejection_Homo sapiens_hsa053302.23455810
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.18366356
10Huntingtons disease_Homo sapiens_hsa050162.09932211
11Autoimmune thyroid disease_Homo sapiens_hsa053202.04486231
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02131284
13Homologous recombination_Homo sapiens_hsa034401.99541539
14Protein export_Homo sapiens_hsa030601.99470428
15Cardiac muscle contraction_Homo sapiens_hsa042601.97118286
16Alzheimers disease_Homo sapiens_hsa050101.96044015
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93507172
18Primary immunodeficiency_Homo sapiens_hsa053401.86814246
19One carbon pool by folate_Homo sapiens_hsa006701.78900241
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78743246
21Basal transcription factors_Homo sapiens_hsa030221.78070249
22Linoleic acid metabolism_Homo sapiens_hsa005911.77150577
23Mismatch repair_Homo sapiens_hsa034301.73874331
24RNA degradation_Homo sapiens_hsa030181.68383476
25Phototransduction_Homo sapiens_hsa047441.66811123
26Graft-versus-host disease_Homo sapiens_hsa053321.66081793
27Fanconi anemia pathway_Homo sapiens_hsa034601.63964727
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56696137
29Type I diabetes mellitus_Homo sapiens_hsa049401.51033660
30DNA replication_Homo sapiens_hsa030301.48145795
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48002271
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37921505
33Pyrimidine metabolism_Homo sapiens_hsa002401.37107845
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31316259
35Spliceosome_Homo sapiens_hsa030401.30217605
36Nucleotide excision repair_Homo sapiens_hsa034201.22607600
37Propanoate metabolism_Homo sapiens_hsa006401.19325730
38Caffeine metabolism_Homo sapiens_hsa002321.18280308
39RNA transport_Homo sapiens_hsa030131.18066862
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13204041
41Antigen processing and presentation_Homo sapiens_hsa046121.08988261
42Purine metabolism_Homo sapiens_hsa002301.06241153
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03897463
44Base excision repair_Homo sapiens_hsa034100.99681474
45Nitrogen metabolism_Homo sapiens_hsa009100.98165344
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97398345
47Ether lipid metabolism_Homo sapiens_hsa005650.91444367
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84285885
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83247566
50Peroxisome_Homo sapiens_hsa041460.82567475
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80124464
52Butanoate metabolism_Homo sapiens_hsa006500.78567775
53Arachidonic acid metabolism_Homo sapiens_hsa005900.72739879
54Tryptophan metabolism_Homo sapiens_hsa003800.71450767
55Non-homologous end-joining_Homo sapiens_hsa034500.70986728
56Olfactory transduction_Homo sapiens_hsa047400.70795877
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.70313825
58Hematopoietic cell lineage_Homo sapiens_hsa046400.69137572
59Chemical carcinogenesis_Homo sapiens_hsa052040.68815576
60Nicotine addiction_Homo sapiens_hsa050330.67337048
61Regulation of autophagy_Homo sapiens_hsa041400.66059204
62Rheumatoid arthritis_Homo sapiens_hsa053230.64118897
63Steroid biosynthesis_Homo sapiens_hsa001000.62806618
64Sulfur relay system_Homo sapiens_hsa041220.62263962
65Metabolic pathways_Homo sapiens_hsa011000.58518396
66Fat digestion and absorption_Homo sapiens_hsa049750.58168221
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58101992
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56442936
69Retinol metabolism_Homo sapiens_hsa008300.55682186
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51396945
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51368507
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.50453479
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50078380
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48253536
75Morphine addiction_Homo sapiens_hsa050320.46992312
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43524087
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43345281
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.41615171
79Systemic lupus erythematosus_Homo sapiens_hsa053220.40762105
80T cell receptor signaling pathway_Homo sapiens_hsa046600.39011994
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38174960
82beta-Alanine metabolism_Homo sapiens_hsa004100.36766716
83Viral myocarditis_Homo sapiens_hsa054160.34756059
84Glutathione metabolism_Homo sapiens_hsa004800.34668004
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34185807
86Taste transduction_Homo sapiens_hsa047420.30725161
87Ovarian steroidogenesis_Homo sapiens_hsa049130.29862927
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.29373056
89Serotonergic synapse_Homo sapiens_hsa047260.28441374
90Folate biosynthesis_Homo sapiens_hsa007900.27549174
91Hedgehog signaling pathway_Homo sapiens_hsa043400.26457137
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26235513
93Epstein-Barr virus infection_Homo sapiens_hsa051690.22197415
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22054836
95Collecting duct acid secretion_Homo sapiens_hsa049660.19548172
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.18301742
97Salivary secretion_Homo sapiens_hsa049700.15169991
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.14923425
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14305026
100Selenocompound metabolism_Homo sapiens_hsa004500.14240620

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