PTMS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)5.02104962
2regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.53854066
3protein retention in ER lumen (GO:0006621)4.21730865
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94996661
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.90737141
6L-phenylalanine metabolic process (GO:0006558)3.90737141
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.86609385
8L-phenylalanine catabolic process (GO:0006559)3.86609385
9alpha-linolenic acid metabolic process (GO:0036109)3.78647748
10pyrimidine nucleobase catabolic process (GO:0006208)3.76098466
11sulfur amino acid catabolic process (GO:0000098)3.59019563
12synaptic vesicle maturation (GO:0016188)3.57658960
13layer formation in cerebral cortex (GO:0021819)3.54330521
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.53282160
15cochlea morphogenesis (GO:0090103)3.49332969
16convergent extension (GO:0060026)3.47506365
17Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.44703081
18regulation of cholesterol homeostasis (GO:2000188)3.40408181
19lysine metabolic process (GO:0006553)3.34023652
20lysine catabolic process (GO:0006554)3.34023652
21locomotory exploration behavior (GO:0035641)3.33416009
22cellular modified amino acid catabolic process (GO:0042219)3.31088762
23cell-cell junction maintenance (GO:0045217)3.30450845
24aromatic amino acid family catabolic process (GO:0009074)3.28722155
25glyoxylate metabolic process (GO:0046487)3.27753060
26negative regulation of fibrinolysis (GO:0051918)3.26849058
27nucleobase catabolic process (GO:0046113)3.23023406
28semaphorin-plexin signaling pathway (GO:0071526)3.22657352
29regulation of establishment of planar polarity (GO:0090175)3.22176530
30kynurenine metabolic process (GO:0070189)3.21831049
31basement membrane organization (GO:0071711)3.17009657
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12569182
33regulation of fatty acid beta-oxidation (GO:0031998)3.08703199
34dicarboxylic acid biosynthetic process (GO:0043650)3.08179574
35regulation of early endosome to late endosome transport (GO:2000641)3.07705108
36positive regulation of fatty acid beta-oxidation (GO:0032000)3.04825973
37bile acid biosynthetic process (GO:0006699)3.04252673
38paraxial mesoderm development (GO:0048339)3.02388654
39adherens junction assembly (GO:0034333)2.99560744
40negative regulation of sterol transport (GO:0032372)2.97034006
41negative regulation of cholesterol transport (GO:0032375)2.97034006
42glutamate metabolic process (GO:0006536)2.96811887
43urea cycle (GO:0000050)2.96461027
44urea metabolic process (GO:0019627)2.96461027
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94819133
46cysteine metabolic process (GO:0006534)2.92387788
47cellular ketone body metabolic process (GO:0046950)2.92365496
48high-density lipoprotein particle remodeling (GO:0034375)2.90711409
49peptidyl-glutamic acid carboxylation (GO:0017187)2.84973954
50protein carboxylation (GO:0018214)2.84973954
51endothelial cell chemotaxis (GO:0035767)2.84554569
52skeletal muscle organ development (GO:0060538)2.84389448
53camera-type eye morphogenesis (GO:0048593)2.82985918
54Golgi transport vesicle coating (GO:0048200)2.81527550
55COPI coating of Golgi vesicle (GO:0048205)2.81527550
56regulation of fibrinolysis (GO:0051917)2.79877285
57indole-containing compound catabolic process (GO:0042436)2.79029059
58indolalkylamine catabolic process (GO:0046218)2.79029059
59tryptophan catabolic process (GO:0006569)2.79029059
60coenzyme catabolic process (GO:0009109)2.77654488
61regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77023660
62postsynaptic membrane organization (GO:0001941)2.72592462
63heterochromatin organization (GO:0070828)2.72350569
64axon extension involved in axon guidance (GO:0048846)2.70908765
65neuron projection extension involved in neuron projection guidance (GO:1902284)2.70908765
66cerebellar granule cell differentiation (GO:0021707)2.70722729
67dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69140961
68positive regulation of lipid catabolic process (GO:0050996)2.68494053
69alanine transport (GO:0032328)2.68094488
70axon extension (GO:0048675)2.67791080
71nucleosome disassembly (GO:0006337)2.67596829
72protein-DNA complex disassembly (GO:0032986)2.67596829
73negative regulation of cell size (GO:0045792)2.67506414
74non-canonical Wnt signaling pathway (GO:0035567)2.67398649
75cell migration in hindbrain (GO:0021535)2.67361591
76cerebellar Purkinje cell layer development (GO:0021680)2.63807166
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.63499984
78serine family amino acid catabolic process (GO:0009071)2.63451653
79nitrogen cycle metabolic process (GO:0071941)2.63414096
80complement activation, alternative pathway (GO:0006957)2.63151403
81drug catabolic process (GO:0042737)2.60750243
82protein heterotrimerization (GO:0070208)2.60748920
83maternal placenta development (GO:0001893)2.59121583
84epoxygenase P450 pathway (GO:0019373)2.57445563
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56839497
86reverse cholesterol transport (GO:0043691)2.56574675
87plasma lipoprotein particle clearance (GO:0034381)2.56363316
88regulation of glucose import in response to insulin stimulus (GO:2001273)2.55227743
89bile acid metabolic process (GO:0008206)2.55106131
90neural tube development (GO:0021915)2.54964967
91glutamate secretion (GO:0014047)2.54738838
92skin morphogenesis (GO:0043589)2.54552229
93proline transport (GO:0015824)2.53778531
94regulation of NFAT protein import into nucleus (GO:0051532)2.53682754
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53575314
96apical protein localization (GO:0045176)2.53061066
97eye morphogenesis (GO:0048592)2.52910610
98cell-substrate adherens junction assembly (GO:0007045)2.52587264
99focal adhesion assembly (GO:0048041)2.52587264
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.52548766
101tryptophan metabolic process (GO:0006568)2.52340902
102cellular response to prostaglandin stimulus (GO:0071379)2.51996906
103vocalization behavior (GO:0071625)2.51777036
104notochord development (GO:0030903)2.50581676
105positive regulation of fatty acid oxidation (GO:0046321)2.50412492
106positive regulation of synapse maturation (GO:0090129)2.49650640
107alpha-amino acid catabolic process (GO:1901606)2.49121707
108cell communication by electrical coupling (GO:0010644)2.48972714
109establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48399964
110homocysteine metabolic process (GO:0050667)2.48194678
111regulation of protein activation cascade (GO:2000257)2.47863709
112arginine metabolic process (GO:0006525)2.47824320
113barbed-end actin filament capping (GO:0051016)2.47449918
114sodium ion export (GO:0071436)2.47358109
115regulation of synapse structural plasticity (GO:0051823)2.47173688
116ketone body metabolic process (GO:1902224)2.47082556
117regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46764152
118cellular amino acid catabolic process (GO:0009063)2.46507657
119dendritic spine morphogenesis (GO:0060997)2.45770092
120aspartate family amino acid catabolic process (GO:0009068)2.44473598
121negative regulation of microtubule polymerization (GO:0031115)2.43566546
122cell junction maintenance (GO:0034331)2.42706864
123G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.42702528
124regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41531475
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41410868
126regulation of triglyceride catabolic process (GO:0010896)2.41054881
127exogenous drug catabolic process (GO:0042738)2.41019163
128protein targeting to plasma membrane (GO:0072661)2.40638005
129establishment or maintenance of apical/basal cell polarity (GO:0035088)2.40102367
130establishment or maintenance of bipolar cell polarity (GO:0061245)2.40102367
131triglyceride homeostasis (GO:0070328)2.40039908
132acylglycerol homeostasis (GO:0055090)2.40039908
133establishment of apical/basal cell polarity (GO:0035089)2.39679116
134activation of protein kinase A activity (GO:0034199)2.39167779
135regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.38552527
136amino-acid betaine metabolic process (GO:0006577)2.38166886
137regulation of cholesterol esterification (GO:0010872)2.37500211
138acetyl-CoA metabolic process (GO:0006084)2.37246581
139kidney mesenchyme development (GO:0072074)2.37206404
140protein-lipid complex remodeling (GO:0034368)2.36764246
141macromolecular complex remodeling (GO:0034367)2.36764246
142plasma lipoprotein particle remodeling (GO:0034369)2.36764246
143negative regulation of catenin import into nucleus (GO:0035414)2.36426141
144dendrite morphogenesis (GO:0048813)2.36230175
145diaphragm development (GO:0060539)2.35629797
146mating behavior (GO:0007617)2.35351280
147phosphate ion transport (GO:0006817)2.35135302
148neuron projection extension (GO:1990138)2.34975161
149cranial nerve morphogenesis (GO:0021602)2.34935901
150positive regulation of axon extension (GO:0045773)2.34399558
151neuromuscular process controlling balance (GO:0050885)2.33916612
152negative regulation of chondrocyte differentiation (GO:0032331)2.33853120
153regulation of fatty acid oxidation (GO:0046320)2.32909450
154cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.32791532
155regulation of axon extension involved in axon guidance (GO:0048841)2.32683956
156regulation of complement activation (GO:0030449)2.32363728
157lens fiber cell development (GO:0070307)2.31089709
1582-oxoglutarate metabolic process (GO:0006103)2.31002798
159midgut development (GO:0007494)2.30845609
160myelination in peripheral nervous system (GO:0022011)2.29560854
161peripheral nervous system axon ensheathment (GO:0032292)2.29560854
162negative regulation of fatty acid transport (GO:2000192)2.28813320
163negative regulation of lipid transport (GO:0032369)2.28731528
164regulation of glutamate receptor signaling pathway (GO:1900449)2.28603536
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28459112
166epithelial cell-cell adhesion (GO:0090136)2.27216426
167collagen fibril organization (GO:0030199)2.26001865
168neuron recognition (GO:0008038)2.24893200
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24837788
170cellular potassium ion homeostasis (GO:0030007)2.24487703
171outer ear morphogenesis (GO:0042473)2.22913923
172RNA localization (GO:0006403)2.22172221
173positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.21533368
174proline biosynthetic process (GO:0006561)2.20265735
175dopamine receptor signaling pathway (GO:0007212)2.19259903
176glucocorticoid receptor signaling pathway (GO:0042921)2.18563954
177axonal fasciculation (GO:0007413)2.18057452
178apoptotic process involved in morphogenesis (GO:0060561)2.17261997
179intracellular estrogen receptor signaling pathway (GO:0030520)2.16459899
180developmental cell growth (GO:0048588)2.14465792
181protein localization to endosome (GO:0036010)2.13429669
182negative regulation of embryonic development (GO:0045992)2.13131004
183positive regulation of blood vessel endothelial cell migration (GO:0043536)2.12668032
184regulation of catenin import into nucleus (GO:0035412)2.11313800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25310898
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.18213852
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.88759364
4PPARA_22158963_ChIP-Seq_LIVER_Mouse2.76291513
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.52809647
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47762077
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.21778375
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16104415
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.09834322
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07563856
11LXR_22292898_ChIP-Seq_THP-1_Human2.07187017
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.02472796
13KDM2B_26808549_Chip-Seq_K562_Human1.99834960
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90414494
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88602732
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84043690
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81318211
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81318211
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80893304
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74308055
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70073111
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67576493
23ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66036901
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.65278944
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65101489
26CLOCK_20551151_ChIP-Seq_293T_Human1.64955343
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64219900
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.63499206
29ZNF263_19887448_ChIP-Seq_K562_Human1.62035151
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.58939896
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57992191
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57977084
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57887048
34DROSHA_22980978_ChIP-Seq_HELA_Human1.57289324
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56183156
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56181308
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.55593406
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52573466
39KDM2B_26808549_Chip-Seq_DND41_Human1.52184802
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51658592
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.51563859
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50768133
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49575244
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.49317336
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48649255
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48294902
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47325368
48EZH2_22144423_ChIP-Seq_EOC_Human1.45825690
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43715186
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43244027
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42528532
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41898165
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40934433
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.38010038
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37147069
56* FOXM1_23109430_ChIP-Seq_U2OS_Human1.35069486
57MYC_22102868_ChIP-Seq_BL_Human1.34895934
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.33490554
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32654341
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32248575
61* CREB1_26743006_Chip-Seq_LNCaP_Human1.30078790
62* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28542376
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.28075248
64VDR_21846776_ChIP-Seq_THP-1_Human1.27784557
65* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27393974
66* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26700567
67* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26518516
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.24872573
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24650197
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24233282
71TP53_22127205_ChIP-Seq_IMR90_Human1.23529117
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.22573058
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22342322
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21185301
75SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20373316
76* CTCF_27219007_Chip-Seq_Bcells_Human1.19948901
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19465111
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19199880
79* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19136642
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18813274
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.18287968
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.17389530
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17222296
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16534893
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16516057
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16378072
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.15327965
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14320372
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13980374
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13959688
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13564386
92* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13010306
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12922983
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12504247
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12383027
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11130245
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.11091411
98STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09379083
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.09371078
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08857957
101REST_21632747_ChIP-Seq_MESCs_Mouse1.07714081
102SMC4_20622854_ChIP-Seq_HELA_Human1.07607175
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07419339
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07008974
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06760784
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03973587
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03943328
108CDX2_20551321_ChIP-Seq_CACO-2_Human1.03450231
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03343871
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02926036
111* TCF7_22412390_ChIP-Seq_EML_Mouse1.02910427
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.99384953
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94546086
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94350352
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.93358872
116* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92264040
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91956428
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91807707
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91430351
120* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89707447
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89306113
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88995639
123* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88651423
124* P68_20966046_ChIP-Seq_HELA_Human0.86621847
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86610108
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.85867095
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83697481
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.83175218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.59600483
2MP0005360_urolithiasis4.40788935
3MP0003705_abnormal_hypodermis_morpholog3.88894453
4MP0004859_abnormal_synaptic_plasticity3.61073340
5MP0005085_abnormal_gallbladder_physiolo3.48987119
6MP0005365_abnormal_bile_salt3.36279994
7MP0004858_abnormal_nervous_system2.79718218
8MP0008875_abnormal_xenobiotic_pharmacok2.52720351
9MP0003252_abnormal_bile_duct2.50690688
10MP0010329_abnormal_lipoprotein_level2.32844240
11MP0000566_synostosis2.14012834
12MP0002877_abnormal_melanocyte_morpholog2.10819155
13MP0009840_abnormal_foam_cell2.00800167
14MP0003283_abnormal_digestive_organ1.93946378
15MP0008961_abnormal_basal_metabolism1.91466349
16MP0005083_abnormal_biliary_tract1.86563312
17MP0005503_abnormal_tendon_morphology1.86065085
18MP0009780_abnormal_chondrocyte_physiolo1.85448641
19MP0003329_amyloid_beta_deposits1.80081010
20MP0003635_abnormal_synaptic_transmissio1.70863037
21MP0002909_abnormal_adrenal_gland1.70815307
22MP0003123_paternal_imprinting1.69949382
23MP0005409_darkened_coat_color1.64425736
24MP0005332_abnormal_amino_acid1.62810605
25MP0004270_analgesia1.59379004
26MP0000049_abnormal_middle_ear1.57713028
27MP0002822_catalepsy1.55726524
28MP0010234_abnormal_vibrissa_follicle1.55402944
29MP0003385_abnormal_body_wall1.54158071
30MP0004130_abnormal_muscle_cell1.52230379
31MP0005623_abnormal_meninges_morphology1.48321127
32MP0000579_abnormal_nail_morphology1.45306060
33MP0003191_abnormal_cellular_cholesterol1.43233929
34MP0002063_abnormal_learning/memory/cond1.42817366
35MP0002697_abnormal_eye_size1.39990661
36MP0009379_abnormal_foot_pigmentation1.39277327
37MP0002118_abnormal_lipid_homeostasis1.37683866
38MP0001849_ear_inflammation1.31835289
39MP0004019_abnormal_vitamin_homeostasis1.30983107
40MP0005248_abnormal_Harderian_gland1.28692156
41MP0009250_abnormal_appendicular_skeleto1.27606604
42MP0003279_aneurysm1.27444601
43MP0000762_abnormal_tongue_morphology1.27328800
44MP0005167_abnormal_blood-brain_barrier1.27321270
45MP0004885_abnormal_endolymph1.25436911
46MP0005508_abnormal_skeleton_morphology1.24253874
47MP0000733_abnormal_muscle_development1.23955159
48MP0000428_abnormal_craniofacial_morphol1.23453804
49MP0002116_abnormal_craniofacial_bone1.23214381
50MP0001299_abnormal_eye_distance/1.22440932
51MP0001666_abnormal_nutrient_absorption1.22243579
52MP0003075_altered_response_to1.22136407
53MP0003122_maternal_imprinting1.20645824
54MP0008438_abnormal_cutaneous_collagen1.20190713
55MP0003861_abnormal_nervous_system1.18724571
56MP0000604_amyloidosis1.18157130
57MP0002254_reproductive_system_inflammat1.14974857
58MP0005187_abnormal_penis_morphology1.14970833
59MP0002932_abnormal_joint_morphology1.14282474
60MP0003195_calcinosis1.14098122
61MP0002653_abnormal_ependyma_morphology1.13615697
62MP0009672_abnormal_birth_weight1.13094924
63MP0010368_abnormal_lymphatic_system1.10745485
64MP0003938_abnormal_ear_development1.10557607
65MP0009053_abnormal_anal_canal1.10534333
66MP0000609_abnormal_liver_physiology1.09330282
67MP0000462_abnormal_digestive_system1.08596155
68MP0003634_abnormal_glial_cell1.07960649
69MP0000534_abnormal_ureter_morphology1.07460025
70MP0002092_abnormal_eye_morphology1.06691118
71MP0009384_cardiac_valve_regurgitation1.05003716
72MP0001346_abnormal_lacrimal_gland1.04974753
73MP0004233_abnormal_muscle_weight1.04040177
74MP0000778_abnormal_nervous_system1.02821140
75MP0003755_abnormal_palate_morphology1.02701979
76MP0005076_abnormal_cell_differentiation1.02440404
77MP0004185_abnormal_adipocyte_glucose1.01189301
78MP0005319_abnormal_enzyme/_coenzyme1.01161881
79MP0009745_abnormal_behavioral_response0.98404533
80MP0004811_abnormal_neuron_physiology0.95882964
81MP0005275_abnormal_skin_tensile0.95608287
82MP0010030_abnormal_orbit_morphology0.95312892
83MP0003935_abnormal_craniofacial_develop0.95040166
84MP0002152_abnormal_brain_morphology0.93924354
85MP0001348_abnormal_lacrimal_gland0.93647912
86MP0005666_abnormal_adipose_tissue0.93431463
87MP0002064_seizures0.93270220
88MP0005584_abnormal_enzyme/coenzyme_acti0.92749592
89MP0004272_abnormal_basement_membrane0.92722930
90MP0002114_abnormal_axial_skeleton0.92578019
91MP0003091_abnormal_cell_migration0.92407432
92MP0002234_abnormal_pharynx_morphology0.92354021
93MP0000537_abnormal_urethra_morphology0.92014126
94MP0000751_myopathy0.91960751
95MP0002896_abnormal_bone_mineralization0.90686407
96MP0002060_abnormal_skin_morphology0.90228576
97MP0000955_abnormal_spinal_cord0.89628195
98MP0003119_abnormal_digestive_system0.89267480
99MP0001502_abnormal_circadian_rhythm0.88693953
100MP0005058_abnormal_lysosome_morphology0.88195904
101MP0001188_hyperpigmentation0.87291826
102MP0002085_abnormal_embryonic_tissue0.87246801
103MP0000432_abnormal_head_morphology0.87035732
104MP0003011_delayed_dark_adaptation0.86968947
105MP0002081_perinatal_lethality0.86013763
106MP0002089_abnormal_postnatal_growth/wei0.84701259
107MP0002733_abnormal_thermal_nociception0.84688654
108MP0002837_dystrophic_cardiac_calcinosis0.82576983
109MP0003937_abnormal_limbs/digits/tail_de0.81656759
110MP0002233_abnormal_nose_morphology0.81363224
111MP0003303_peritoneal_inflammation0.80489224
112MP0003115_abnormal_respiratory_system0.79745876
113MP0002572_abnormal_emotion/affect_behav0.79534103
114MP0002108_abnormal_muscle_morphology0.78651195
115MP0000767_abnormal_smooth_muscle0.77221358
116MP0005375_adipose_tissue_phenotype0.76989112
117MP0005670_abnormal_white_adipose0.76937876
118MP0003566_abnormal_cell_adhesion0.76355279
119MP0002111_abnormal_tail_morphology0.76179275
120MP0005257_abnormal_intraocular_pressure0.76143151
121MP0003806_abnormal_nucleotide_metabolis0.75305420
122MP0008874_decreased_physiological_sensi0.74986373
123MP0005197_abnormal_uvea_morphology0.74564485
124MP0002090_abnormal_vision0.74471826
125MP0001730_embryonic_growth_arrest0.73722711
126MP0001756_abnormal_urination0.73424188
127MP0003868_abnormal_feces_composition0.72772654
128MP0003942_abnormal_urinary_system0.72772010
129MP0002882_abnormal_neuron_morphology0.72688758
130MP0000467_abnormal_esophagus_morphology0.72602609
131MP0005423_abnormal_somatic_nervous0.72249510
132MP0009643_abnormal_urine_homeostasis0.72097171
133MP0002138_abnormal_hepatobiliary_system0.71678485
134MP0001958_emphysema0.71494078
135MP0005501_abnormal_skin_physiology0.71454696
136MP0002069_abnormal_eating/drinking_beha0.70367659
137MP0003633_abnormal_nervous_system0.70268975
138MP0001915_intracranial_hemorrhage0.69940033
139MP0001879_abnormal_lymphatic_vessel0.68795812
140MP0003315_abnormal_perineum_morphology0.67999342
141MP0002078_abnormal_glucose_homeostasis0.67865120
142MP0003300_gastrointestinal_ulcer0.67714250
143MP0004087_abnormal_muscle_fiber0.67137204
144MP0000681_abnormal_thyroid_gland0.67070704
145MP0002796_impaired_skin_barrier0.66345546
146MP0003879_abnormal_hair_cell0.65942634
147MP0002734_abnormal_mechanical_nocicepti0.65390938
148MP0002249_abnormal_larynx_morphology0.65025655
149MP0005535_abnormal_body_temperature0.64904291
150MP0003690_abnormal_glial_cell0.64883698
151MP0000003_abnormal_adipose_tissue0.63416680
152MP0002184_abnormal_innervation0.60664045
153MP0001440_abnormal_grooming_behavior0.58105030
154MP0001177_atelectasis0.57903593
155MP0000678_abnormal_parathyroid_gland0.57859961

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.47660387
2Abnormality of the lower motor neuron (HP:0002366)3.80662503
3Xanthomatosis (HP:0000991)3.45235766
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23191005
5Myokymia (HP:0002411)2.97324789
6Abnormality of monocarboxylic acid metabolism (HP:0010996)2.96438296
7Ulnar bowing (HP:0003031)2.94797245
8Abnormality of the Achilles tendon (HP:0005109)2.92486965
9Intrahepatic cholestasis (HP:0001406)2.90890090
10Turricephaly (HP:0000262)2.85465251
11Shallow orbits (HP:0000586)2.81507106
12Lymphangioma (HP:0100764)2.78672747
13Complement deficiency (HP:0004431)2.76850243
14Abnormality of dentin (HP:0010299)2.74594565
15Neonatal short-limb short stature (HP:0008921)2.67471108
16Achilles tendon contracture (HP:0001771)2.62612737
17Protrusio acetabuli (HP:0003179)2.59611231
18Ketosis (HP:0001946)2.58179590
19Gout (HP:0001997)2.58172554
20Hepatoblastoma (HP:0002884)2.53516550
21Hyperlipoproteinemia (HP:0010980)2.52616054
22Upper limb amyotrophy (HP:0009129)2.51402896
23Distal upper limb amyotrophy (HP:0007149)2.51402896
24Epidermoid cyst (HP:0200040)2.50483560
25Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47231369
26Hyperacusis (HP:0010780)2.46793134
27Fragile skin (HP:0001030)2.45476412
28Bowel diverticulosis (HP:0005222)2.40568181
29Disproportionate tall stature (HP:0001519)2.39950871
30Insomnia (HP:0100785)2.37978409
31Ketoacidosis (HP:0001993)2.36356983
32Torticollis (HP:0000473)2.35256903
33Cerebral inclusion bodies (HP:0100314)2.32994620
34Biconcave vertebral bodies (HP:0004586)2.27750552
35Elfin facies (HP:0004428)2.26701310
36Long palpebral fissure (HP:0000637)2.26311213
37Renovascular hypertension (HP:0100817)2.26127147
38Spinal rigidity (HP:0003306)2.25766680
39Hand muscle atrophy (HP:0009130)2.25423075
40Mitral regurgitation (HP:0001653)2.25185192
41Arnold-Chiari malformation (HP:0002308)2.24931734
42Hypoalphalipoproteinemia (HP:0003233)2.24546261
43Neonatal onset (HP:0003623)2.24357023
44Vertebral compression fractures (HP:0002953)2.23259915
45Hyperammonemia (HP:0001987)2.23173484
46Hyperglycinuria (HP:0003108)2.21673419
47Cerebral aneurysm (HP:0004944)2.19559005
48Ankle contracture (HP:0006466)2.18638072
49Supranuclear gaze palsy (HP:0000605)2.18006234
50Atrophic scars (HP:0001075)2.15512005
51Skin nodule (HP:0200036)2.15398533
52Abnormality of complement system (HP:0005339)2.14550294
53Flat cornea (HP:0007720)2.13478257
54Abnormality of the aortic arch (HP:0012303)2.13099907
55Asymmetry of the thorax (HP:0001555)2.12575795
56Hypobetalipoproteinemia (HP:0003563)2.10717699
57Blue sclerae (HP:0000592)2.10013754
58Thin ribs (HP:0000883)2.09761682
59Hypoventilation (HP:0002791)2.09752863
60Back pain (HP:0003418)2.09694574
61Renal duplication (HP:0000075)2.09455185
62Coronal craniosynostosis (HP:0004440)2.08376135
63Focal dystonia (HP:0004373)2.06656068
64Broad metatarsal (HP:0001783)2.05478122
65Vascular tortuosity (HP:0004948)2.04140616
66Hyperextensible skin (HP:0000974)2.03996453
67Mitral valve prolapse (HP:0001634)2.03475036
68Pseudobulbar signs (HP:0002200)2.03233670
69Craniofacial dystonia (HP:0012179)2.02643188
70Patellar dislocation (HP:0002999)2.02365252
71Neurofibrillary tangles (HP:0002185)2.01760601
72Bronchomalacia (HP:0002780)2.01485651
73Abnormality of serine family amino acid metabolism (HP:0010894)2.00604088
74Abnormality of glycine metabolism (HP:0010895)2.00604088
75Wormian bones (HP:0002645)2.00040840
76Arterial tortuosity (HP:0005116)1.97566205
77Hypolipoproteinemia (HP:0010981)1.95965873
78Delayed CNS myelination (HP:0002188)1.95107854
79Increased nuchal translucency (HP:0010880)1.94593629
80Wide anterior fontanel (HP:0000260)1.94377572
81Soft skin (HP:0000977)1.94252851
82Obstructive sleep apnea (HP:0002870)1.94008506
83Peritonitis (HP:0002586)1.93641576
84Broad face (HP:0000283)1.92575072
85Hyperparathyroidism (HP:0000843)1.92554837
86Bladder diverticulum (HP:0000015)1.92492451
87Hypercalcemia (HP:0003072)1.92296368
88Spastic diplegia (HP:0001264)1.92107973
89Status epilepticus (HP:0002133)1.92033336
90Hyperglycinemia (HP:0002154)1.90221904
91Aplasia involving bones of the upper limbs (HP:0009823)1.89576809
92Aplasia of the phalanges of the hand (HP:0009802)1.89576809
93Aplasia involving bones of the extremities (HP:0009825)1.89576809
94Action tremor (HP:0002345)1.89201178
95Cervical subluxation (HP:0003308)1.85661718
96Partial duplication of the phalanx of hand (HP:0009999)1.85421467
97Vertebral arch anomaly (HP:0008438)1.84885775
98Aortic dissection (HP:0002647)1.84821313
99Abnormality of the calcaneus (HP:0008364)1.84559263
100Visual hallucinations (HP:0002367)1.83073804
101Precocious puberty (HP:0000826)1.82940754
102Long toe (HP:0010511)1.81985079
103Abnormality of the diencephalon (HP:0010662)1.79652183
104Broad distal phalanx of finger (HP:0009836)1.78468901
105Nuclear cataract (HP:0100018)1.78283304
106Enlarged penis (HP:0000040)1.76969159
107Hypercholesterolemia (HP:0003124)1.76442972
108Cortical dysplasia (HP:0002539)1.74882821
109Megalocornea (HP:0000485)1.74815771
110Neoplasm of the heart (HP:0100544)1.74815636
111Abnormal cartilage morphology (HP:0002763)1.74573835
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.74179552
113Premature rupture of membranes (HP:0001788)1.73966748
114Partial duplication of thumb phalanx (HP:0009944)1.73585424
115Abnormality of the phalanges of the hallux (HP:0010057)1.73088473
116Myocardial infarction (HP:0001658)1.73009345
117Visceral angiomatosis (HP:0100761)1.72950165
118Abnormal social behavior (HP:0012433)1.72546582
119Impaired social interactions (HP:0000735)1.72546582
120Polygenic inheritance (HP:0010982)1.71628468
121Congenital glaucoma (HP:0001087)1.70941926
122Trigonocephaly (HP:0000243)1.70637741
123Prolonged partial thromboplastin time (HP:0003645)1.69981224
124Macroorchidism (HP:0000053)1.68997389
125Overriding aorta (HP:0002623)1.67839724
126Malnutrition (HP:0004395)1.67797419
127Abnormality of the common coagulation pathway (HP:0010990)1.67299899
128Increased connective tissue (HP:0009025)1.67293951
129Increased variability in muscle fiber diameter (HP:0003557)1.66989906
130Joint laxity (HP:0001388)1.66213000
131Hallux valgus (HP:0001822)1.66039845
132Deviation of the hallux (HP:0010051)1.65988283
133Hepatocellular carcinoma (HP:0001402)1.65709594
134Midface retrusion (HP:0011800)1.65610852
135Broad thumb (HP:0011304)1.65447976
136Hamartoma of the eye (HP:0010568)1.65409616
137Bowed forearm bones (HP:0003956)1.65188752
138Bowing of the arm (HP:0006488)1.65188752
139Aneurysm (HP:0002617)1.64877389
140Hypercortisolism (HP:0001578)1.64857170
141Pointed chin (HP:0000307)1.64743742
142Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64661647
143Megalencephaly (HP:0001355)1.63449484
144Abnormality of sulfur amino acid metabolism (HP:0004339)1.63414826
145Hemiplegia (HP:0002301)1.62464821
146Thin bony cortex (HP:0002753)1.62400611
147Genu recurvatum (HP:0002816)1.62339963
148Amyotrophic lateral sclerosis (HP:0007354)1.62304727
149Difficulty running (HP:0009046)1.61954461
150Venous abnormality (HP:0002624)1.61949867
151Calcaneovalgus deformity (HP:0001848)1.61927275
152Lower limb amyotrophy (HP:0007210)1.61277046
153Morphological abnormality of the middle ear (HP:0008609)1.61013747
154Natal tooth (HP:0000695)1.60448824
155Hemangiomatosis (HP:0007461)1.59538532
156Mitral stenosis (HP:0001718)1.59245230
157Mildly elevated creatine phosphokinase (HP:0008180)1.59131606
158Abnormality of purine metabolism (HP:0004352)1.58742330
159Annular pancreas (HP:0001734)1.58609959
160Broad long bones (HP:0005622)1.58499547
161Choanal stenosis (HP:0000452)1.58410988
162High anterior hairline (HP:0009890)1.58087053
163Hypoglycemic coma (HP:0001325)1.57868302
164Focal seizures (HP:0007359)1.57783333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.37474519
2PKN22.75126096
3MARK12.67255384
4SMG12.58294155
5ERN12.56630831
6MAP3K92.55069438
7RIPK12.34114362
8DAPK22.15852286
9SIK12.11734912
10LATS22.10842414
11EPHA42.02148105
12PAK61.99125550
13KSR21.92400623
14PRKD31.90743307
15TYRO31.89616000
16PDGFRA1.85603270
17ICK1.82328581
18CAMKK11.76995406
19PRPF4B1.73401932
20NTRK11.68464691
21SIK21.66226238
22DDR21.64372031
23EPHB21.62142980
24TAOK11.60309904
25MAP3K101.56206378
26PTK61.45331636
27MINK11.45052931
28NTRK31.37874934
29MAP2K41.31757464
30FGFR41.24497790
31EPHA21.24429635
32BMX1.22250395
33PTK21.18481910
34RET1.16369997
35NME21.16031018
36ARAF1.16000295
37NEK11.15881713
38STK381.10862472
39KSR11.10584377
40BCKDK1.08676774
41ALK1.07844548
42MAP3K21.07712722
43PHKG21.06494317
44PHKG11.06494317
45LIMK11.04779413
46IRAK31.01954195
47NTRK21.01417796
48MAP3K40.99676499
49CDK120.99057477
50CAMK1G0.98155160
51PAK30.96010906
52MARK20.92614274
53TAOK20.92406034
54BRAF0.91535950
55MAP3K70.90159340
56LMTK20.89946329
57ERBB20.87924677
58GRK50.85197560
59FER0.84014885
60PRKCH0.82183945
61CDK50.82146977
62LATS10.79757544
63TTN0.79116440
64PRKCZ0.79034102
65CAMK1D0.78232857
66RPS6KB20.76980813
67FGFR20.76025044
68BRSK10.75470209
69EEF2K0.75168165
70DYRK1B0.75033100
71DMPK0.74761006
72MTOR0.74737629
73MAP2K10.74704251
74MOS0.72259671
75CAMK40.71495076
76STK110.70286083
77CDK70.69808286
78NEK20.68955230
79ROCK20.67600588
80DAPK10.64119142
81PAK20.63365545
82DAPK30.60525017
83MET0.59821254
84UHMK10.59649277
85CDK150.58109247
86RPS6KC10.57694560
87RPS6KL10.57694560
88CDC42BPA0.57376723
89PAK40.56613764
90DYRK20.56168113
91PDPK10.55853207
92RPS6KA20.54417411
93CDK140.54079152
94PRKCG0.53996836
95ILK0.53788498
96PDGFRB0.53735763
97PRKD10.53201204
98CDK180.53151310
99AKT20.51933343
100VRK20.51076709
101BRD40.51005486
102MAPK120.49842049
103CDK11A0.49517740
104FGFR10.47901199
105MAP2K20.47843590
106TESK20.47411781
107MAP3K10.47197779
108PTK2B0.46587277
109PRKD20.46344205
110SGK30.44961719
111PRKAA10.44729256
112LRRK20.43792124
113HIPK20.43586202
114MAP3K80.43581461
115ROCK10.42393073
116ERBB40.42083489
117AURKA0.41981074
118MAPK100.41403722
119GSK3A0.41047412
120CDK60.41043311
121PRKG20.40784762
122MST1R0.40436485
123TGFBR20.40236005
124PNCK0.40131443
125CAMK2G0.39964051
126MATK0.39773975
127TESK10.39397792
128WNK40.38463112
129SCYL20.38075114
130CDK90.37845565
131CAMK2B0.37700232
132PDK10.37696829
133ABL20.37674616
134GRK60.37579211
135MAPKAPK30.37339170
136MAP3K110.37186216
137RPS6KA60.35664835
138CSNK1E0.34291689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.63555364
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96594484
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.78290410
4Arginine biosynthesis_Homo sapiens_hsa002202.46455061
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20878627
6Notch signaling pathway_Homo sapiens_hsa043301.92891645
7Bile secretion_Homo sapiens_hsa049761.81460256
8Butanoate metabolism_Homo sapiens_hsa006501.77590811
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75997814
10Basal cell carcinoma_Homo sapiens_hsa052171.73415227
11Tryptophan metabolism_Homo sapiens_hsa003801.73075111
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71391157
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70911485
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66661813
15Fatty acid degradation_Homo sapiens_hsa000711.65948466
16ECM-receptor interaction_Homo sapiens_hsa045121.61605510
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55683329
18Chronic myeloid leukemia_Homo sapiens_hsa052201.52824114
19PPAR signaling pathway_Homo sapiens_hsa033201.52437042
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46636967
21Hippo signaling pathway_Homo sapiens_hsa043901.46396262
22Complement and coagulation cascades_Homo sapiens_hsa046101.41140337
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40022814
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39301386
25Fatty acid metabolism_Homo sapiens_hsa012121.36090565
26Hedgehog signaling pathway_Homo sapiens_hsa043401.35023616
27Adherens junction_Homo sapiens_hsa045201.30693495
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30660914
29Vitamin B6 metabolism_Homo sapiens_hsa007501.25340123
30Thyroid cancer_Homo sapiens_hsa052161.18913584
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16919268
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16308040
33Sulfur relay system_Homo sapiens_hsa041221.14305205
34Vibrio cholerae infection_Homo sapiens_hsa051101.13733541
35MicroRNAs in cancer_Homo sapiens_hsa052061.09778990
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09177666
37Pentose phosphate pathway_Homo sapiens_hsa000301.08290468
38Wnt signaling pathway_Homo sapiens_hsa043101.07045358
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06164158
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05952102
41Renal cell carcinoma_Homo sapiens_hsa052111.05165161
42Synaptic vesicle cycle_Homo sapiens_hsa047211.03863785
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03587898
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.02082871
45Propanoate metabolism_Homo sapiens_hsa006401.02017730
46Tight junction_Homo sapiens_hsa045300.95899269
47Fructose and mannose metabolism_Homo sapiens_hsa000510.93765238
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93478349
49Protein digestion and absorption_Homo sapiens_hsa049740.92707302
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90850418
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90320307
52GABAergic synapse_Homo sapiens_hsa047270.89209373
53Pancreatic cancer_Homo sapiens_hsa052120.87816709
54Colorectal cancer_Homo sapiens_hsa052100.87595415
55Glioma_Homo sapiens_hsa052140.87291774
56Lysine degradation_Homo sapiens_hsa003100.87158342
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86510570
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84903388
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83072478
60beta-Alanine metabolism_Homo sapiens_hsa004100.82912245
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81757376
62Chemical carcinogenesis_Homo sapiens_hsa052040.81057556
63Melanoma_Homo sapiens_hsa052180.80636760
64Peroxisome_Homo sapiens_hsa041460.80629309
65Prostate cancer_Homo sapiens_hsa052150.79948207
66Prion diseases_Homo sapiens_hsa050200.79668990
67Fat digestion and absorption_Homo sapiens_hsa049750.79112289
68Biosynthesis of amino acids_Homo sapiens_hsa012300.78630679
69Circadian entrainment_Homo sapiens_hsa047130.78023794
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.77249031
71Arginine and proline metabolism_Homo sapiens_hsa003300.77031159
72mTOR signaling pathway_Homo sapiens_hsa041500.76297021
73Phenylalanine metabolism_Homo sapiens_hsa003600.75908646
74Type II diabetes mellitus_Homo sapiens_hsa049300.75604446
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75113087
76Pyruvate metabolism_Homo sapiens_hsa006200.74412940
77Carbon metabolism_Homo sapiens_hsa012000.74246993
78Galactose metabolism_Homo sapiens_hsa000520.73327443
79Glutamatergic synapse_Homo sapiens_hsa047240.73312334
80Olfactory transduction_Homo sapiens_hsa047400.73108063
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72727455
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72488721
83Axon guidance_Homo sapiens_hsa043600.72422585
84Gastric acid secretion_Homo sapiens_hsa049710.72159706
85Insulin resistance_Homo sapiens_hsa049310.71104036
86Endometrial cancer_Homo sapiens_hsa052130.70937100
87Bladder cancer_Homo sapiens_hsa052190.70063327
88Estrogen signaling pathway_Homo sapiens_hsa049150.69420426
89Long-term potentiation_Homo sapiens_hsa047200.69418400
90Rap1 signaling pathway_Homo sapiens_hsa040150.69050294
91Small cell lung cancer_Homo sapiens_hsa052220.69014638
92Starch and sucrose metabolism_Homo sapiens_hsa005000.68535715
93Gap junction_Homo sapiens_hsa045400.67983805
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.67634409
95Insulin secretion_Homo sapiens_hsa049110.67026936
96Salivary secretion_Homo sapiens_hsa049700.66830003
97Dopaminergic synapse_Homo sapiens_hsa047280.66427688
98Cholinergic synapse_Homo sapiens_hsa047250.66406492
99Choline metabolism in cancer_Homo sapiens_hsa052310.65861990
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.64507547
101Fatty acid biosynthesis_Homo sapiens_hsa000610.64201564
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64194546
103Cocaine addiction_Homo sapiens_hsa050300.63940131
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63931466
105GnRH signaling pathway_Homo sapiens_hsa049120.63843837
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.63091752
107Pathways in cancer_Homo sapiens_hsa052000.61892551
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61099600
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60935964
110AMPK signaling pathway_Homo sapiens_hsa041520.60913739
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.60611259
112Staphylococcus aureus infection_Homo sapiens_hsa051500.60410473
113Insulin signaling pathway_Homo sapiens_hsa049100.60352466
114Oxytocin signaling pathway_Homo sapiens_hsa049210.57544272
115Amphetamine addiction_Homo sapiens_hsa050310.57362395
116Glucagon signaling pathway_Homo sapiens_hsa049220.57241764
117Histidine metabolism_Homo sapiens_hsa003400.56949229
118VEGF signaling pathway_Homo sapiens_hsa043700.56944049
119mRNA surveillance pathway_Homo sapiens_hsa030150.56758449
120Glycerolipid metabolism_Homo sapiens_hsa005610.56714597
121Caffeine metabolism_Homo sapiens_hsa002320.56524966
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56197006
123Acute myeloid leukemia_Homo sapiens_hsa052210.55774269
124Endocytosis_Homo sapiens_hsa041440.55268229
125Melanogenesis_Homo sapiens_hsa049160.54787163
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54656794
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54285974
128Renin secretion_Homo sapiens_hsa049240.53429213
129Non-small cell lung cancer_Homo sapiens_hsa052230.52321120
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51647566
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51545689
132Tyrosine metabolism_Homo sapiens_hsa003500.51012729
133Dilated cardiomyopathy_Homo sapiens_hsa054140.50731487
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50285459
135Retinol metabolism_Homo sapiens_hsa008300.49959962
136Focal adhesion_Homo sapiens_hsa045100.48662281
137Amoebiasis_Homo sapiens_hsa051460.48045191
138Proteoglycans in cancer_Homo sapiens_hsa052050.48041915
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47016853
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46888296
141ErbB signaling pathway_Homo sapiens_hsa040120.46585697
142Thyroid hormone synthesis_Homo sapiens_hsa049180.45731178
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.45730786

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