PTP4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1uronic acid metabolic process (GO:0006063)6.82550110
2glucuronate metabolic process (GO:0019585)6.82550110
3cellular glucuronidation (GO:0052695)6.71872276
4negative regulation of fatty acid transport (GO:2000192)6.39295967
5regulation of chemokine secretion (GO:0090196)5.03728047
6nucleotide transmembrane transport (GO:1901679)4.97214387
7inner ear receptor cell differentiation (GO:0060113)4.86917582
8regulation of protein activation cascade (GO:2000257)4.83678711
9limb bud formation (GO:0060174)4.79734914
10negative regulation of protein activation cascade (GO:2000258)4.75907893
11regulation of complement activation (GO:0030449)4.67296833
12negative regulation of fibrinolysis (GO:0051918)4.63216547
13intestinal cholesterol absorption (GO:0030299)4.54081978
14phenylpropanoid metabolic process (GO:0009698)4.35242491
15positive regulation of chemokine secretion (GO:0090197)4.29510789
16urea metabolic process (GO:0019627)4.29016937
17xenobiotic catabolic process (GO:0042178)4.28847527
18myoblast migration (GO:0051451)4.26361756
19negative regulation of complement activation (GO:0045916)4.25404969
20regulation of fibrinolysis (GO:0051917)4.22465050
21urea cycle (GO:0000050)4.18452725
22nucleotide-sugar biosynthetic process (GO:0009226)4.13404351
23very-low-density lipoprotein particle assembly (GO:0034379)4.10995439
24regulation of phospholipase A2 activity (GO:0032429)4.10586868
25energy homeostasis (GO:0097009)4.09740650
26negative regulation of keratinocyte proliferation (GO:0010839)4.08359017
27replicative senescence (GO:0090399)4.06276595
28ER overload response (GO:0006983)3.99582913
29cell differentiation involved in metanephros development (GO:0072202)3.96254025
30nitrogen cycle metabolic process (GO:0071941)3.88876794
31L-phenylalanine metabolic process (GO:0006558)3.82814629
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82814629
33cell aggregation (GO:0098743)3.80949081
34cartilage condensation (GO:0001502)3.80949081
35L-phenylalanine catabolic process (GO:0006559)3.72529036
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72529036
37protein carboxylation (GO:0018214)3.68531086
38peptidyl-glutamic acid carboxylation (GO:0017187)3.68531086
39cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.68092413
40midgut development (GO:0007494)3.63978676
41regulation of metalloenzyme activity (GO:0048552)3.61849804
42positive regulation of actin filament depolymerization (GO:0030836)3.58033848
43Golgi transport vesicle coating (GO:0048200)3.50521654
44COPI coating of Golgi vesicle (GO:0048205)3.50521654
45mechanoreceptor differentiation (GO:0042490)3.50460080
46glomerulus development (GO:0032835)3.48177181
47daunorubicin metabolic process (GO:0044597)3.42711957
48polyketide metabolic process (GO:0030638)3.42711957
49doxorubicin metabolic process (GO:0044598)3.42711957
50notochord development (GO:0030903)3.38682331
51cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.36054835
52signal peptide processing (GO:0006465)3.32145844
53prostaglandin biosynthetic process (GO:0001516)3.29054623
54prostanoid biosynthetic process (GO:0046457)3.29054623
55homocysteine metabolic process (GO:0050667)3.21023574
56COPII vesicle coating (GO:0048208)3.19148797
57pyrimidine-containing compound transmembrane transport (GO:0072531)3.18986233
58plasma lipoprotein particle assembly (GO:0034377)3.18130007
59myelin assembly (GO:0032288)3.16963913
60cholesterol biosynthetic process (GO:0006695)3.16453761
61hepatocyte differentiation (GO:0070365)3.16101898
62response to nitrosative stress (GO:0051409)3.14976685
63positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.14456794
64DNA double-strand break processing (GO:0000729)3.12491104
653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.09492274
66purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.09492274
67purine ribonucleotide transport (GO:0015868)3.09225548
68cellular response to gamma radiation (GO:0071480)3.08772517
69glutamate metabolic process (GO:0006536)3.08296171
70one-carbon compound transport (GO:0019755)3.07703774
71negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.06466501
72regulation of skeletal muscle contraction (GO:0014819)3.05981460
73blood coagulation, intrinsic pathway (GO:0007597)3.05911368
74complement activation, alternative pathway (GO:0006957)3.04346626
75positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.04043285
76response to follicle-stimulating hormone (GO:0032354)3.01533700
77aminoglycoside antibiotic metabolic process (GO:0030647)2.98521268
78iron ion import (GO:0097286)2.98371579
79muscle cell migration (GO:0014812)2.96349389
80pyrimidine nucleobase catabolic process (GO:0006208)2.94907035
81Notch signaling involved in heart development (GO:0061314)2.90639835
82regulation of cholesterol homeostasis (GO:2000188)2.89034095
83nucleobase catabolic process (GO:0046113)2.87297266
84negative regulation of lipase activity (GO:0060192)2.86384784
85cholesterol efflux (GO:0033344)2.86089023
86cysteine metabolic process (GO:0006534)2.85411581
87neural crest cell development (GO:0014032)2.85315237
88negative regulation of signal transduction by p53 class mediator (GO:1901797)2.84175355
89gluconeogenesis (GO:0006094)2.83125396
90polyol transport (GO:0015791)2.81630293
91negative regulation of myoblast differentiation (GO:0045662)2.81476087
92protein-lipid complex assembly (GO:0065005)2.79702432
93nucleotide transport (GO:0006862)2.79045698
94positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.78776396
95chondrocyte development (GO:0002063)2.78774101
96sterol biosynthetic process (GO:0016126)2.78771222
97positive regulation of icosanoid secretion (GO:0032305)2.78427089
98negative regulation of humoral immune response (GO:0002921)2.77994461
99fibrinolysis (GO:0042730)2.76655926
100negative regulation of chemokine production (GO:0032682)2.74048556
101bone remodeling (GO:0046849)2.72129542
102myelin maintenance (GO:0043217)2.71296357
103cellular response to BMP stimulus (GO:0071773)2.71080405
104response to BMP (GO:0071772)2.71080405
105negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.70690348
106intestinal absorption (GO:0050892)2.70317271
107endothelial cell morphogenesis (GO:0001886)2.70113089
108hexose biosynthetic process (GO:0019319)2.68964930
109endocardial cushion morphogenesis (GO:0003203)2.68568426
110regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.68140872
111prostanoid metabolic process (GO:0006692)2.67441842
112prostaglandin metabolic process (GO:0006693)2.67441842
113regulation of plasminogen activation (GO:0010755)2.67223337
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67170640
115central nervous system myelination (GO:0022010)2.65645662
116axon ensheathment in central nervous system (GO:0032291)2.65645662
117amyloid precursor protein catabolic process (GO:0042987)2.63912717
118plasma lipoprotein particle remodeling (GO:0034369)2.63414551
119protein-lipid complex remodeling (GO:0034368)2.63414551
120macromolecular complex remodeling (GO:0034367)2.63414551
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61287688
122cell adhesion mediated by integrin (GO:0033627)2.61194984
123layer formation in cerebral cortex (GO:0021819)2.60662276
124regulation of cholesterol biosynthetic process (GO:0045540)2.59541599
125glycogen catabolic process (GO:0005980)2.58642214
126sphingomyelin metabolic process (GO:0006684)2.58476249
127dicarboxylic acid biosynthetic process (GO:0043650)2.57791221
128endoplasmic reticulum organization (GO:0007029)2.57612794
129fatty acid elongation (GO:0030497)2.57089774
130heart valve morphogenesis (GO:0003179)2.56766577
131protein K11-linked deubiquitination (GO:0035871)2.56536109
132calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.56262951
133negative regulation of mast cell activation (GO:0033004)2.55911857
134regulation of bile acid biosynthetic process (GO:0070857)2.55005959
135female gonad development (GO:0008585)2.54973042
136tyrosine metabolic process (GO:0006570)2.53110258
137viral protein processing (GO:0019082)2.51506401
138L-ascorbic acid metabolic process (GO:0019852)2.51381521
139glutamine family amino acid catabolic process (GO:0009065)2.51366221
140serine family amino acid biosynthetic process (GO:0009070)2.50882439
141cranial suture morphogenesis (GO:0060363)2.50832329
142smooth muscle tissue development (GO:0048745)2.50828174
143interleukin-6-mediated signaling pathway (GO:0070102)2.50557073
144negative regulation of glycogen biosynthetic process (GO:0045719)2.50556306
145positive regulation of mitochondrial fission (GO:0090141)2.48430721
146glycerophospholipid catabolic process (GO:0046475)2.48086253
147negative regulation of JUN kinase activity (GO:0043508)2.47796223
148regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.47689285
149ganglion development (GO:0061548)2.47495431
150L-serine metabolic process (GO:0006563)2.46399533
151regulation of icosanoid secretion (GO:0032303)2.45715639
152high-density lipoprotein particle remodeling (GO:0034375)2.45518560
153citrulline metabolic process (GO:0000052)2.45485535
154magnesium ion transport (GO:0015693)2.44975139
155polarized epithelial cell differentiation (GO:0030859)2.44885438
1564-hydroxyproline metabolic process (GO:0019471)2.44700743
157exogenous drug catabolic process (GO:0042738)2.44142087
158eye photoreceptor cell differentiation (GO:0001754)2.43775148
159photoreceptor cell differentiation (GO:0046530)2.43775148
160glyoxylate metabolic process (GO:0046487)2.43770958
161regulation of integrin-mediated signaling pathway (GO:2001044)2.43761647
162negative regulation of cholesterol transport (GO:0032375)2.43508010
163negative regulation of sterol transport (GO:0032372)2.43508010
164positive regulation of pseudopodium assembly (GO:0031274)2.42958403
165plasma lipoprotein particle organization (GO:0071827)2.41916047
166negative regulation of cytokine secretion (GO:0050710)2.41570405
167cyclooxygenase pathway (GO:0019371)2.41063793
168microtubule polymerization or depolymerization (GO:0031109)2.40581010
169citrulline biosynthetic process (GO:0019240)2.40492774
170protein retention in ER lumen (GO:0006621)2.39291226
171otic vesicle formation (GO:0030916)2.39200521
172low-density lipoprotein particle remodeling (GO:0034374)2.35765490
173establishment of mitochondrion localization (GO:0051654)2.34259903
174serine family amino acid metabolic process (GO:0009069)2.34006721
175alpha-linolenic acid metabolic process (GO:0036109)2.32782071
176response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.32687576
177nuclear pore complex assembly (GO:0051292)2.32091031
178glycolytic process (GO:0006096)2.31790884
179glucan catabolic process (GO:0009251)2.31734994
180monosaccharide biosynthetic process (GO:0046364)2.31728318
181vesicle coating (GO:0006901)2.31091089
182reverse cholesterol transport (GO:0043691)2.30946808
183response to muscle activity (GO:0014850)2.29716992
184embryonic retina morphogenesis in camera-type eye (GO:0060059)2.27487488
185protein hydroxylation (GO:0018126)2.27226632
186regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.25824232
187protein-lipid complex subunit organization (GO:0071825)2.25574579
188response to mercury ion (GO:0046689)2.24656163
189glutamine metabolic process (GO:0006541)2.24517929
190plasma lipoprotein particle clearance (GO:0034381)2.24235561
191bile acid metabolic process (GO:0008206)2.23212560
192serine family amino acid catabolic process (GO:0009071)2.22458970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human4.71761701
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.11863552
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.44022294
4CLOCK_20551151_ChIP-Seq_293T_Human3.17835954
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.93108200
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87788861
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87207554
8* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.84478459
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.71563636
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.66957991
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60426893
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51099987
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49866930
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40823259
15AR_21909140_ChIP-Seq_LNCAP_Human2.33141357
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32715579
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.30007970
18* FLI1_27457419_Chip-Seq_LIVER_Mouse2.28683084
19IGF1R_20145208_ChIP-Seq_DFB_Human2.24664692
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22700387
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13328687
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13081993
23* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.12535191
24* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01547152
25* LXR_22158963_ChIP-Seq_LIVER_Mouse2.01398967
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01123900
27* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.97344399
28* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.97344399
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.96866191
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96414949
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86061041
32* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84284663
33AR_21572438_ChIP-Seq_LNCaP_Human1.82762767
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82443299
35* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.80278799
36FUS_26573619_Chip-Seq_HEK293_Human1.79174844
37ER_23166858_ChIP-Seq_MCF-7_Human1.77693737
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77078584
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76912053
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.74515841
41CJUN_26792858_Chip-Seq_BT549_Human1.72197489
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71805316
43GBX2_23144817_ChIP-Seq_PC3_Human1.71634797
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69121409
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.69020534
46* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68718273
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67013671
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66846004
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65376033
50* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60337698
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.59277412
52* TP53_18474530_ChIP-ChIP_U2OS_Human1.58583788
53DCP1A_22483619_ChIP-Seq_HELA_Human1.58326688
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57396795
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.57246206
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56736219
57* NANOG_18555785_Chip-Seq_ESCs_Mouse1.56179762
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54815515
59* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54653386
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54404128
61* NFE2_27457419_Chip-Seq_LIVER_Mouse1.54177177
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53263844
63EWS_26573619_Chip-Seq_HEK293_Human1.52451402
64P300_19829295_ChIP-Seq_ESCs_Human1.52191592
65* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51765711
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51016952
67* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49917331
68TAF15_26573619_Chip-Seq_HEK293_Human1.49825591
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49515705
70* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49162690
71* E2F1_18555785_Chip-Seq_ESCs_Mouse1.48720336
72* EZH2_27294783_Chip-Seq_NPCs_Mouse1.47989788
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47754574
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47482146
75SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47369994
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46767615
77* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46633372
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45353681
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44651541
80* FOXA2_19822575_ChIP-Seq_HepG2_Human1.44291770
81* CMYC_18555785_Chip-Seq_ESCs_Mouse1.44011099
82* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43386737
83SOX2_20726797_ChIP-Seq_SW620_Human1.42109071
84* P53_22387025_ChIP-Seq_ESCs_Mouse1.41328153
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39813075
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39398351
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39245934
88* STAT3_18555785_Chip-Seq_ESCs_Mouse1.37941350
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37875465
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37720626
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35763515
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35701023
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34959860
94* SOX2_18555785_Chip-Seq_ESCs_Mouse1.34515759
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.34150622
96* P300_18555785_Chip-Seq_ESCs_Mouse1.34094946
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33120613
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32848834
99* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.31320569
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30691803
101* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30038357
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28416181
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.27877302
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.27412045
105AHR_22903824_ChIP-Seq_MCF-7_Human1.27411993
106* NMYC_18555785_Chip-Seq_ESCs_Mouse1.27237223
107* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27075454
108* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25887955
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25707387
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25418298
111* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25100374
112ELK1_19687146_ChIP-ChIP_HELA_Human1.24661713
113SOX17_20123909_ChIP-Seq_XEN_Mouse1.22705584
114* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22611910
115* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22611910
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22485816
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21722766
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.20981909
119* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18696679
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18639977
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18448435
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18099357
123* CRX_20693478_ChIP-Seq_RETINA_Mouse1.18097288
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17955576
125* OCT4_18555785_Chip-Seq_ESCs_Mouse1.17531783
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16227117
127NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16121659
128CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15958130
129* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15947528
130ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14823040
131GF1B_26923725_Chip-Seq_HPCs_Mouse1.14477428
132CHD1_26751641_Chip-Seq_LNCaP_Human1.14012665
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13733778
134EP300_21415370_ChIP-Seq_HL-1_Mouse1.12871212
135* KLF4_18555785_Chip-Seq_ESCs_Mouse1.12169300
136REST_19997604_ChIP-ChIP_NEURONS_Mouse1.11924152
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11652297
138RNF2_27304074_Chip-Seq_NSC_Mouse1.09825260
139* PU1_27457419_Chip-Seq_LIVER_Mouse1.09111483
140GATA6_25053715_ChIP-Seq_YYC3_Human1.08978149
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08895372
142RXR_22108803_ChIP-Seq_LS180_Human1.07927192
143* ZFX_18555785_Chip-Seq_ESCs_Mouse1.07075459
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06727298
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.06345204
146* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06216628
147TP63_17297297_ChIP-ChIP_HaCaT_Human1.04469517
148ARNT_22903824_ChIP-Seq_MCF-7_Human1.04405095
149* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03249581
150XRN2_22483619_ChIP-Seq_HELA_Human1.01911879
151CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01899471
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00298800
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00144880
154* CDX2_22108803_ChIP-Seq_LS180_Human0.99235788
155KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97718704
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93682475
157ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91342978
158CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91231447
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91131300
160NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89160757
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88060344
162ESR2_21235772_ChIP-Seq_MCF-7_Human0.87099957
163* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86654384
164PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83823287
165GABP_19822575_ChIP-Seq_HepG2_Human0.83402733
166GATA4_25053715_ChIP-Seq_YYC3_Human0.82750947
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81474812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.65218313
2MP0005499_abnormal_olfactory_system4.31734706
3MP0005394_taste/olfaction_phenotype4.31734706
4MP0010030_abnormal_orbit_morphology3.35242148
5MP0003122_maternal_imprinting3.24541901
6MP0002877_abnormal_melanocyte_morpholog2.99325178
7MP0001984_abnormal_olfaction2.96448805
8MP0005365_abnormal_bile_salt2.71244501
9MP0009250_abnormal_appendicular_skeleto2.70286870
10MP0004134_abnormal_chest_morphology2.53450379
11MP0002009_preneoplasia2.42438471
12MP0005503_abnormal_tendon_morphology2.37953656
13MP0000013_abnormal_adipose_tissue2.35233270
14MP0000566_synostosis2.29246714
15MP0005408_hypopigmentation2.23039837
16MP0002233_abnormal_nose_morphology2.15412770
17MP0009697_abnormal_copulation2.14516620
18MP0003950_abnormal_plasma_membrane2.13442839
19MP0003868_abnormal_feces_composition2.08817444
20MP0010234_abnormal_vibrissa_follicle2.04241085
21MP0004233_abnormal_muscle_weight2.04058560
22MP0003186_abnormal_redox_activity2.02531250
23MP0004782_abnormal_surfactant_physiolog2.01847124
24MP0009053_abnormal_anal_canal1.99767180
25MP0001177_atelectasis1.99490868
26MP0003937_abnormal_limbs/digits/tail_de1.91463220
27MP0005360_urolithiasis1.90431232
28MP0001346_abnormal_lacrimal_gland1.90331131
29MP0000762_abnormal_tongue_morphology1.88371154
30MP0005171_absent_coat_pigmentation1.84817036
31MP0002282_abnormal_trachea_morphology1.84579914
32MP0001919_abnormal_reproductive_system1.83874747
33MP0005187_abnormal_penis_morphology1.81162404
34MP0005083_abnormal_biliary_tract1.79264454
35MP0001666_abnormal_nutrient_absorption1.78170860
36MP0003755_abnormal_palate_morphology1.75547784
37MP0003221_abnormal_cardiomyocyte_apopto1.74548526
38MP0005248_abnormal_Harderian_gland1.73964201
39MP0000003_abnormal_adipose_tissue1.72030935
40MP0008875_abnormal_xenobiotic_pharmacok1.71876315
41MP0005647_abnormal_sex_gland1.69976319
42MP0005508_abnormal_skeleton_morphology1.68182776
43MP0002160_abnormal_reproductive_system1.67666756
44MP0002933_joint_inflammation1.64814898
45MP0003252_abnormal_bile_duct1.63256917
46MP0000163_abnormal_cartilage_morphology1.62057821
47MP0002132_abnormal_respiratory_system1.61033109
48MP0005389_reproductive_system_phenotype1.59870220
49MP0005451_abnormal_body_composition1.58192649
50MP0010329_abnormal_lipoprotein_level1.57451129
51MP0001529_abnormal_vocalization1.56732272
52MP0000049_abnormal_middle_ear1.56086826
53MP0002277_abnormal_respiratory_mucosa1.56085378
54MP0000751_myopathy1.55650912
55MP0008438_abnormal_cutaneous_collagen1.51439761
56MP0005646_abnormal_pituitary_gland1.50254106
57MP0003656_abnormal_erythrocyte_physiolo1.48242295
58MP0000372_irregular_coat_pigmentation1.45874829
59MP0005623_abnormal_meninges_morphology1.45654285
60MP0002133_abnormal_respiratory_system1.44628317
61MP0005388_respiratory_system_phenotype1.44628317
62MP0000613_abnormal_salivary_gland1.42914129
63MP0003806_abnormal_nucleotide_metabolis1.38046433
64MP0004270_analgesia1.36170929
65MP0003890_abnormal_embryonic-extraembry1.36082722
66MP0002697_abnormal_eye_size1.34154913
67MP0008057_abnormal_DNA_replication1.30912873
68MP0005076_abnormal_cell_differentiation1.29512351
69MP0002249_abnormal_larynx_morphology1.28741645
70MP0003315_abnormal_perineum_morphology1.26763327
71MP0002269_muscular_atrophy1.24321080
72MP0005332_abnormal_amino_acid1.21780278
73MP0003195_calcinosis1.21532264
74MP0006292_abnormal_olfactory_placode1.21433956
75MP0002876_abnormal_thyroid_physiology1.20196837
76MP0001851_eye_inflammation1.19982977
77MP0001958_emphysema1.17917236
78MP0002115_abnormal_skeleton_extremities1.17245161
79MP0001542_abnormal_bone_strength1.16516511
80MP0005377_hearing/vestibular/ear_phenot1.15001000
81MP0003878_abnormal_ear_physiology1.15001000
82MP0004197_abnormal_fetal_growth/weight/1.14091913
83MP0003718_maternal_effect1.12983151
84MP0005390_skeleton_phenotype1.12839487
85MP0003279_aneurysm1.12096523
86MP0003943_abnormal_hepatobiliary_system1.11052135
87MP0001188_hyperpigmentation1.10586959
88MP0003941_abnormal_skin_development1.10125531
89MP0003121_genomic_imprinting1.09292883
90MP0002909_abnormal_adrenal_gland1.09281291
91MP0001299_abnormal_eye_distance/1.08317137
92MP0001915_intracranial_hemorrhage1.06571139
93MP0003136_yellow_coat_color1.04952952
94MP0002971_abnormal_brown_adipose1.04176010
95MP0002113_abnormal_skeleton_development1.03097752
96MP0000733_abnormal_muscle_development1.02340322
97MP0008007_abnormal_cellular_replicative1.02339550
98MP0002234_abnormal_pharynx_morphology1.02130799
99MP0005367_renal/urinary_system_phenotyp1.01799030
100MP0000516_abnormal_urinary_system1.01799030
101MP0004272_abnormal_basement_membrane1.01103591
102MP0002098_abnormal_vibrissa_morphology1.00889709
103MP0001286_abnormal_eye_development1.00782705
104MP0010352_gastrointestinal_tract_polyps0.99362318
105MP0004087_abnormal_muscle_fiber0.98766327
106MP0003786_premature_aging0.97221046
107MP0009780_abnormal_chondrocyte_physiolo0.96464002
108MP0000579_abnormal_nail_morphology0.96133636
109MP0003115_abnormal_respiratory_system0.95755090
110MP0003942_abnormal_urinary_system0.95721283
111MP0005085_abnormal_gallbladder_physiolo0.95604366
112MP0002092_abnormal_eye_morphology0.93397858
113MP0006054_spinal_hemorrhage0.93232648
114MP0002109_abnormal_limb_morphology0.93027799
115MP0000537_abnormal_urethra_morphology0.92513088
116MP0010368_abnormal_lymphatic_system0.91145147
117MP0002060_abnormal_skin_morphology0.90991963
118MP0001661_extended_life_span0.90504532
119MP0002332_abnormal_exercise_endurance0.90265741
120MP0000609_abnormal_liver_physiology0.89910954
121MP0002106_abnormal_muscle_physiology0.89820675
122MP0005409_darkened_coat_color0.89690642
123MP0002163_abnormal_gland_morphology0.88999996
124MP0002116_abnormal_craniofacial_bone0.87758116
125MP0000778_abnormal_nervous_system0.87231088
126MP0000750_abnormal_muscle_regeneration0.86917839
127MP0000747_muscle_weakness0.86441330
128MP0005257_abnormal_intraocular_pressure0.86305216
129MP0005501_abnormal_skin_physiology0.85759871
130MP0009840_abnormal_foam_cell0.85044439
131MP0005164_abnormal_response_to0.84251998
132MP0002118_abnormal_lipid_homeostasis0.83642707
133MP0002139_abnormal_hepatobiliary_system0.83250383
134MP0003385_abnormal_body_wall0.80225807
135MP0000759_abnormal_skeletal_muscle0.80153609
136MP0001879_abnormal_lymphatic_vessel0.80030956
137MP0002177_abnormal_outer_ear0.79871541
138MP0001270_distended_abdomen0.78390780
139MP0008961_abnormal_basal_metabolism0.76885647
140MP0003567_abnormal_fetal_cardiomyocyte0.76518985
141MP0005197_abnormal_uvea_morphology0.75880896
142MP0003123_paternal_imprinting0.75437773
143MP0000639_abnormal_adrenal_gland0.75070616
144MP0008932_abnormal_embryonic_tissue0.74924520
145MP0000678_abnormal_parathyroid_gland0.74820479
146MP0002295_abnormal_pulmonary_circulatio0.74772108
147MP0005275_abnormal_skin_tensile0.74300112
148MP0001119_abnormal_female_reproductive0.74115639
149MP0005084_abnormal_gallbladder_morpholo0.73435360
150MP0009672_abnormal_birth_weight0.72051628
151MP0000383_abnormal_hair_follicle0.70831356
152MP0003724_increased_susceptibility_to0.70580146
153MP0002111_abnormal_tail_morphology0.70475913
154MP0002938_white_spotting0.69993797
155MP0001963_abnormal_hearing_physiology0.69883261
156MP0010678_abnormal_skin_adnexa0.69649467
157MP0004484_altered_response_of0.69358337
158MP0005423_abnormal_somatic_nervous0.68741524
159MP0002090_abnormal_vision0.68540680
160MP0005375_adipose_tissue_phenotype0.68539862
161MP0005584_abnormal_enzyme/coenzyme_acti0.68303513
162MP0002896_abnormal_bone_mineralization0.68221049
163MP0005369_muscle_phenotype0.67573245
164MP0000026_abnormal_inner_ear0.67422570
165MP0003984_embryonic_growth_retardation0.66817862
166MP0003646_muscle_fatigue0.66551074
167MP0001340_abnormal_eyelid_morphology0.66384839
168MP0003935_abnormal_craniofacial_develop0.65939733
169MP0001485_abnormal_pinna_reflex0.65202312
170MP0000647_abnormal_sebaceous_gland0.65004439
171MP0002088_abnormal_embryonic_growth/wei0.63715769
172MP0003566_abnormal_cell_adhesion0.63428525

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)5.91685601
2Deep venous thrombosis (HP:0002625)5.30708201
3Epiphyseal dysplasia (HP:0002656)5.20611174
4Vitreoretinal degeneration (HP:0000655)5.10426873
5Abnormality of the phalanges of the 2nd finger (HP:0009541)4.74556249
6Hypobetalipoproteinemia (HP:0003563)4.55617791
7Abnormal tarsal ossification (HP:0008369)4.50927501
8Cupped ribs (HP:0000887)4.28325077
9Prolonged partial thromboplastin time (HP:0003645)4.19598360
10Exercise-induced muscle cramps (HP:0003710)4.03824453
11Hypoplastic ischia (HP:0003175)3.97535729
12Abnormality of incisor morphology (HP:0011063)3.97485086
13Abnormality of the ischium (HP:0003174)3.91948608
14Flat capital femoral epiphysis (HP:0003370)3.75565527
15Abnormality of the phalanges of the 5th finger (HP:0004213)3.71225727
16Abnormality of the proximal phalanges of the hand (HP:0009834)3.64984571
17Facial shape deformation (HP:0011334)3.62989329
18Potter facies (HP:0002009)3.62989329
19Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.62178845
20Abnormal foot bone ossification (HP:0010675)3.45528447
21Conjugated hyperbilirubinemia (HP:0002908)3.42410736
22Increased serum pyruvate (HP:0003542)3.40934889
23Abnormality of glycolysis (HP:0004366)3.40614389
24Abnormality of aromatic amino acid family metabolism (HP:0004338)3.40093269
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.23099177
26Small epiphyses (HP:0010585)3.14782621
27Abnormality of the common coagulation pathway (HP:0010990)3.14532162
28Adrenal hypoplasia (HP:0000835)3.13750900
29Complement deficiency (HP:0004431)3.09928976
30Papillary thyroid carcinoma (HP:0002895)3.09140968
31Short femoral neck (HP:0100864)3.03829735
32Epidermoid cyst (HP:0200040)3.03519442
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.00483175
34Delayed epiphyseal ossification (HP:0002663)2.98815169
35Muscle fiber inclusion bodies (HP:0100299)2.97743578
36Abnormality of the middle phalanges of the toes (HP:0010183)2.95371742
37Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.94045820
38Exercise-induced myalgia (HP:0003738)2.93568153
39Genu varum (HP:0002970)2.92226121
40Hypolipoproteinemia (HP:0010981)2.90976416
41Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.88406230
42Abnormality of femoral epiphyses (HP:0006499)2.88406230
43Abnormality of the 2nd finger (HP:0004100)2.86091432
44Nemaline bodies (HP:0003798)2.83601318
45Abnormality of the frontal sinuses (HP:0002687)2.82398309
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.81859097
47Metaphyseal dysplasia (HP:0100255)2.81700560
48Arthropathy (HP:0003040)2.78761617
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.78064068
50Stillbirth (HP:0003826)2.76855646
51Myoglobinuria (HP:0002913)2.76277468
52Aplasia involving bones of the extremities (HP:0009825)2.75340624
53Aplasia involving bones of the upper limbs (HP:0009823)2.75340624
54Aplasia of the phalanges of the hand (HP:0009802)2.75340624
55Stomach cancer (HP:0012126)2.74843589
56Mitral stenosis (HP:0001718)2.74788843
57Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.74103070
58Hypercholesterolemia (HP:0003124)2.73289224
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72593505
60Flat acetabular roof (HP:0003180)2.71778507
61Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.70143784
62Abnormality of the femoral head (HP:0003368)2.68952336
63Abnormality of the epiphysis of the femoral head (HP:0010574)2.62132284
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.59292348
65Absent epiphyses (HP:0010577)2.59292348
66Metaphyseal irregularity (HP:0003025)2.57804885
67Abnormality of the vertebral endplates (HP:0005106)2.55957578
68Irregular vertebral endplates (HP:0003301)2.46536574
69Redundant skin (HP:0001582)2.44639758
70Prostate neoplasm (HP:0100787)2.41975871
71Abnormality of the distal phalanges of the toes (HP:0010182)2.41220950
72Abnormality of the intrinsic pathway (HP:0010989)2.41145092
73Insidious onset (HP:0003587)2.41079669
74Termporal pattern (HP:0011008)2.41079669
75Aplasia/Hypoplasia of the scapulae (HP:0006713)2.40245005
76Hypoplastic scapulae (HP:0000882)2.40245005
77Mild short stature (HP:0003502)2.37365486
78Long clavicles (HP:0000890)2.37342806
79Periauricular skin pits (HP:0100277)2.34783730
80Preauricular pit (HP:0004467)2.34783730
81Joint hemorrhage (HP:0005261)2.33559985
82Pheochromocytoma (HP:0002666)2.33194410
83Overlapping toe (HP:0001845)2.30004895
84Asymmetry of the thorax (HP:0001555)2.28309523
85Abnormality of the nasal septum (HP:0000419)2.27011401
86Submucous cleft hard palate (HP:0000176)2.25933264
87Abnormality of complement system (HP:0005339)2.25092080
88Metaphyseal cupping (HP:0003021)2.24444730
89Fat malabsorption (HP:0002630)2.24017424
90Carpal synostosis (HP:0009702)2.22618142
91Abnormality of the Achilles tendon (HP:0005109)2.19371916
92Vascular calcification (HP:0004934)2.17740843
93Rimmed vacuoles (HP:0003805)2.17642055
94Cortical dysplasia (HP:0002539)2.16842370
95Thyroid carcinoma (HP:0002890)2.16768472
96Calcaneovalgus deformity (HP:0001848)2.16742852
97Hepatoblastoma (HP:0002884)2.16590582
98Aplasia/Hypoplasia of the fibula (HP:0006492)2.15918877
99Intrahepatic cholestasis (HP:0001406)2.15023600
100Rhabdomyolysis (HP:0003201)2.14504993
101Unilateral renal agenesis (HP:0000122)2.14319225
102Hyperammonemia (HP:0001987)2.14176179
103Synostosis of carpal bones (HP:0005048)2.13637691
104Back pain (HP:0003418)2.13017995
105Neonatal short-limb short stature (HP:0008921)2.11299632
106Barrel-shaped chest (HP:0001552)2.10885955
107Aplasia/hypoplasia of the femur (HP:0005613)2.08209406
108Blue irides (HP:0000635)2.06477470
109Shoulder girdle muscle weakness (HP:0003547)2.06213131
110Synostosis involving bones of the hand (HP:0004278)2.05069797
111Abnormality of carpal bone ossification (HP:0006257)2.04931847
112Xanthomatosis (HP:0000991)2.03947244
113Urinary urgency (HP:0000012)2.03596607
114Short hallux (HP:0010109)2.01785186
115Prolonged neonatal jaundice (HP:0006579)2.01046947
116Abnormality of the middle phalanges of the hand (HP:0009833)2.01014945
117Scanning speech (HP:0002168)2.00715967
118Enlarged epiphyses (HP:0010580)2.00081177
119Abnormality of the fibula (HP:0002991)1.99698276
120Fibular hypoplasia (HP:0003038)1.99658000
121Fibular aplasia (HP:0002990)1.99650416
122Fair hair (HP:0002286)1.98960842
123Limb-girdle muscle atrophy (HP:0003797)1.96766717
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96742907
125Broad alveolar ridges (HP:0000187)1.96370443
126Pulmonary artery stenosis (HP:0004415)1.94498843
127Abnormality of the hip-girdle musculature (HP:0001445)1.93265934
128Abnormality of the musculature of the pelvis (HP:0001469)1.93265934
129Abnormality of pain sensation (HP:0010832)1.93157834
130Impaired pain sensation (HP:0007328)1.93157834
131Osteoarthritis (HP:0002758)1.93136722
132Thoracolumbar scoliosis (HP:0002944)1.92921141
133Flattened epiphyses (HP:0003071)1.91829989
134Neoplasm of the adrenal cortex (HP:0100641)1.91212126
135Deformed tarsal bones (HP:0008119)1.89228793
136Neonatal hypoglycemia (HP:0001998)1.89199629
137Gout (HP:0001997)1.88891450
138Hypoplasia of the uterus (HP:0000013)1.88378256
139Lip pit (HP:0100267)1.86784189
140Neuroendocrine neoplasm (HP:0100634)1.86569051
141Micromelia (HP:0002983)1.85702013
142Vertebral arch anomaly (HP:0008438)1.84817340
143Spontaneous abortion (HP:0005268)1.84498070
144Microvesicular hepatic steatosis (HP:0001414)1.83729023
145Abnormal pancreas size (HP:0012094)1.82007431
146Abnormal vertebral ossification (HP:0100569)1.82003765
147Cardiovascular calcification (HP:0011915)1.81289607
148Exocrine pancreatic insufficiency (HP:0001738)1.80598874
149Aplasia/Hypoplasia of the hallux (HP:0008362)1.79558429
150Hyperglycinemia (HP:0002154)1.78580755
151Retinal atrophy (HP:0001105)1.76473856
152Hypoalphalipoproteinemia (HP:0003233)1.76085719
153Pelvic girdle muscle weakness (HP:0003749)1.74468649
154Alveolar cell carcinoma (HP:0006519)1.74451807
155Short nail (HP:0001799)1.73624854
156Open mouth (HP:0000194)1.72457811
157Symphalangism affecting the phalanges of the hand (HP:0009773)1.71078328
158Hammertoe (HP:0001765)1.70990428
159Short middle phalanx of finger (HP:0005819)1.70717366
160Cystic hygroma (HP:0000476)1.70457826
161Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.70200654
162Mixed hearing impairment (HP:0000410)1.70175600
163Bell-shaped thorax (HP:0001591)1.69286823
164Abnormality of the calcaneus (HP:0008364)1.69210953
165Neoplasm of the tracheobronchial system (HP:0100552)1.69040343
166Myopathic facies (HP:0002058)1.68669047
167Acanthocytosis (HP:0001927)1.68596465
168Absent eyebrow (HP:0002223)1.68222946
169Abnormal cartilage morphology (HP:0002763)1.67768193
170Glomerulonephritis (HP:0000099)1.67743997
171Patent foramen ovale (HP:0001655)1.67581535
172Glossoptosis (HP:0000162)1.66350261
173Distal arthrogryposis (HP:0005684)1.65146492
174Proximal tubulopathy (HP:0000114)1.65089604
175Abnormality of glycine metabolism (HP:0010895)1.65048046
176Abnormality of serine family amino acid metabolism (HP:0010894)1.65048046
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64138660
178Upper limb muscle weakness (HP:0003484)1.63352766
179Septate vagina (HP:0001153)1.60387682
180Hepatocellular carcinoma (HP:0001402)1.59941411
181Pterygium (HP:0001059)1.59291850
182Hyperglycinuria (HP:0003108)1.57291520
183Achilles tendon contracture (HP:0001771)1.54105301
184Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.54097653
185Steatorrhea (HP:0002570)1.53425347
186Abnormality of the gastric mucosa (HP:0004295)1.53418190
187Abnormality of the left ventricular outflow tract (HP:0011103)1.52401929
188Subaortic stenosis (HP:0001682)1.52401929
189Broad nasal tip (HP:0000455)1.51673468
190Ragged-red muscle fibers (HP:0003200)1.50878961
191Hyperalaninemia (HP:0003348)1.50244061
192Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.50244061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.74120036
2STK38L3.05889599
3MAP3K32.93679313
4ZAK2.79191146
5BCR2.60609503
6BRD42.52067287
7MARK12.37479457
8NEK62.36719707
9BMPR22.29623113
10CASK2.25710546
11ICK2.24900946
12FRK2.23037932
13MST42.15711383
14TRIM282.15370563
15PRPF4B2.10420574
16MKNK22.09920838
17PBK2.08763101
18CDK122.02776030
19MAP2K72.02760484
20BMPR1B1.96316593
21WNK41.94571391
22NUAK11.94431880
23MAP3K141.91437232
24AKT31.86686771
25TRPM71.82767816
26OBSCN1.82463645
27MKNK11.76036945
28DYRK1B1.74350330
29MAP3K41.73779247
30NEK11.68051349
31STK391.61597179
32PLK21.59673333
33CDK61.54060751
34FGFR41.52579567
35MAPKAPK51.47324840
36PLK31.47216293
37LIMK11.45886469
38SGK21.40869902
39PHKG21.40863020
40PHKG11.40863020
41STK241.40084383
42SGK2231.38781602
43SGK4941.38781602
44EPHA21.38678621
45SIK31.28529028
46VRK11.27394681
47DYRK21.26965082
48EEF2K1.26344309
49OXSR11.24787920
50ADRBK21.24520638
51ERBB41.23788261
52PLK41.20775508
53SRPK11.17130097
54EPHA31.16832746
55TSSK61.16450794
56SCYL21.14198614
57CSNK1A1L1.13369611
58PDK21.12273607
59WEE11.10554402
60RPS6KA41.06874269
61DDR21.06377124
62NME11.04572480
63PINK11.03214384
64MAP2K41.02753580
65BRSK21.01270599
66YES11.00435081
67NEK90.98442649
68PDGFRA0.96347835
69PRKCE0.94462364
70CCNB10.94067290
71FGFR30.90576647
72STK30.90224312
73PRKD30.88001370
74MAP3K50.86445857
75CDK30.85754101
76RIPK10.85553106
77LATS10.85062462
78TXK0.83723333
79CHUK0.83211757
80EIF2AK30.82998303
81EIF2AK20.82304725
82IRAK30.81072647
83PRKG20.80770709
84BUB10.80046790
85PIK3CA0.79109654
86IRAK40.78559737
87MAP3K60.78527555
88DYRK30.78396133
89MAPK150.76949950
90PRKAA10.76924537
91MUSK0.76547055
92FGFR20.74209199
93SIK20.73929134
94AKT20.72885458
95FGFR10.72858188
96TTN0.71694971
97MET0.70817438
98EPHB10.69819392
99CSNK1G30.69778367
100MAPK130.68162680
101TAOK20.67563509
102TESK10.67225946
103PKN10.66200862
104CDK140.64262192
105EPHB20.64200949
106STK160.63832478
107DYRK1A0.63380182
108LMTK20.63329445
109FER0.62963394
110CSNK1G10.62295179
111IKBKB0.61354489
112SGK30.59213488
113RPS6KB10.58858812
114MAP3K20.57163695
115BRSK10.55093951
116RPS6KB20.54210934
117NLK0.54197006
118CSNK1E0.52129824
119MAPK110.50816922
120UHMK10.50707244
121CLK10.49585536
122SIK10.49012258
123CDK80.48503120
124CDK70.48420579
125TEC0.47334876
126MTOR0.46388974
127IKBKE0.46242511
128CAMK2D0.45179206
129RPS6KA50.45076859
130EIF2AK10.44623667
131PIM20.44437842
132GSK3A0.44322993
133CSNK1A10.43370628
134LATS20.43320447
135CDK180.42259480
136MAPK100.42090356
137PRKAA20.41826498
138MAP2K10.41000495
139MAPKAPK30.40830099
140CAMKK20.40391353
141INSRR0.40082428
142MAPK70.39961783
143CAMK2B0.38817137
144PAK30.38752441
145CDK90.38168504
146KSR10.37895031
147NTRK10.37627739
148IRAK10.37493661
149PIM10.35624830
150CSNK1G20.34437554
151MST1R0.34025445
152CDK150.33296710
153CSNK1D0.31392659
154RPS6KA10.30867073
155CDK11A0.28427777
156PRKACB0.28121664
157MAPK90.28108042
158RET0.26909778

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000404.77598074
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.29731188
3Sulfur metabolism_Homo sapiens_hsa009204.07201717
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.06313646
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.13331203
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.06407981
7Arginine biosynthesis_Homo sapiens_hsa002202.88100173
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.84993129
9Complement and coagulation cascades_Homo sapiens_hsa046102.71579892
10Steroid biosynthesis_Homo sapiens_hsa001002.71083067
11Protein export_Homo sapiens_hsa030602.68140921
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.63596167
13Chemical carcinogenesis_Homo sapiens_hsa052042.59882980
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.40965519
15Starch and sucrose metabolism_Homo sapiens_hsa005002.39015438
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.37356287
17Biosynthesis of amino acids_Homo sapiens_hsa012302.21752669
18Retinol metabolism_Homo sapiens_hsa008302.15238585
19Drug metabolism - other enzymes_Homo sapiens_hsa009832.11171200
20Phenylalanine metabolism_Homo sapiens_hsa003601.86435324
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76437743
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74364315
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73190393
24Basal transcription factors_Homo sapiens_hsa030221.67760386
25Glutathione metabolism_Homo sapiens_hsa004801.65945161
26Carbon metabolism_Homo sapiens_hsa012001.62952509
27Fatty acid degradation_Homo sapiens_hsa000711.58240682
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55550974
29Fatty acid elongation_Homo sapiens_hsa000621.50002351
30Sphingolipid metabolism_Homo sapiens_hsa006001.45883643
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42952205
32ECM-receptor interaction_Homo sapiens_hsa045121.33304487
33Pyruvate metabolism_Homo sapiens_hsa006201.31405654
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28489993
35TGF-beta signaling pathway_Homo sapiens_hsa043501.27632048
36Rheumatoid arthritis_Homo sapiens_hsa053231.27340367
37Propanoate metabolism_Homo sapiens_hsa006401.27057650
38Fatty acid metabolism_Homo sapiens_hsa012121.26801065
39Arachidonic acid metabolism_Homo sapiens_hsa005901.26372990
40Bile secretion_Homo sapiens_hsa049761.24870165
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22780825
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.22498364
43Tyrosine metabolism_Homo sapiens_hsa003501.21589255
44Vitamin B6 metabolism_Homo sapiens_hsa007501.19589614
45Fructose and mannose metabolism_Homo sapiens_hsa000511.18260982
46Fat digestion and absorption_Homo sapiens_hsa049751.17463583
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15277523
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14008185
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12852698
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09981644
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09479956
52Phagosome_Homo sapiens_hsa041451.06409626
53Fatty acid biosynthesis_Homo sapiens_hsa000611.03473939
54RNA polymerase_Homo sapiens_hsa030201.02470680
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01900066
56Caffeine metabolism_Homo sapiens_hsa002321.01373334
57Nitrogen metabolism_Homo sapiens_hsa009101.00836318
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00386689
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98049425
60RNA degradation_Homo sapiens_hsa030180.96699339
61Peroxisome_Homo sapiens_hsa041460.95460287
62Butanoate metabolism_Homo sapiens_hsa006500.93366394
63Mineral absorption_Homo sapiens_hsa049780.89781250
64PPAR signaling pathway_Homo sapiens_hsa033200.89676529
65AMPK signaling pathway_Homo sapiens_hsa041520.87789655
66Ether lipid metabolism_Homo sapiens_hsa005650.85849959
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84788889
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83951696
69Prion diseases_Homo sapiens_hsa050200.83748232
70Glucagon signaling pathway_Homo sapiens_hsa049220.82751202
71Vibrio cholerae infection_Homo sapiens_hsa051100.82511976
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81683543
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78834644
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77268012
75Tight junction_Homo sapiens_hsa045300.76978885
76Selenocompound metabolism_Homo sapiens_hsa004500.76882338
77Histidine metabolism_Homo sapiens_hsa003400.76798532
78Hippo signaling pathway_Homo sapiens_hsa043900.76161409
79Lysine degradation_Homo sapiens_hsa003100.75920342
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75775347
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74756089
82Linoleic acid metabolism_Homo sapiens_hsa005910.72528555
83Pentose phosphate pathway_Homo sapiens_hsa000300.72450686
84Galactose metabolism_Homo sapiens_hsa000520.71884921
85Protein digestion and absorption_Homo sapiens_hsa049740.71093628
86Malaria_Homo sapiens_hsa051440.70487625
87Melanoma_Homo sapiens_hsa052180.69556936
88Tryptophan metabolism_Homo sapiens_hsa003800.68769994
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67927790
90Graft-versus-host disease_Homo sapiens_hsa053320.67921743
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.66893461
92Sulfur relay system_Homo sapiens_hsa041220.65159668
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63649103
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62614048
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62513651
96Insulin signaling pathway_Homo sapiens_hsa049100.62102774
97Legionellosis_Homo sapiens_hsa051340.61003759
98Collecting duct acid secretion_Homo sapiens_hsa049660.58199834
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57571731
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56633440
101One carbon pool by folate_Homo sapiens_hsa006700.56062904
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55875208
103Prostate cancer_Homo sapiens_hsa052150.55606805
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55377160
105Folate biosynthesis_Homo sapiens_hsa007900.51631981
106Vitamin digestion and absorption_Homo sapiens_hsa049770.50983211
107Cell cycle_Homo sapiens_hsa041100.49588493
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49351305
109Arginine and proline metabolism_Homo sapiens_hsa003300.47904624
110Proteasome_Homo sapiens_hsa030500.47763720
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47600018
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47101897
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45866482
114Adherens junction_Homo sapiens_hsa045200.45316453
115Non-homologous end-joining_Homo sapiens_hsa034500.45194313
116Insulin resistance_Homo sapiens_hsa049310.44733418
117Circadian rhythm_Homo sapiens_hsa047100.44346247
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.44091395
119Bladder cancer_Homo sapiens_hsa052190.43156704
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.41892644
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41673513
122ABC transporters_Homo sapiens_hsa020100.40513863
123TNF signaling pathway_Homo sapiens_hsa046680.40509239
124Autoimmune thyroid disease_Homo sapiens_hsa053200.40273790
125Renin-angiotensin system_Homo sapiens_hsa046140.38815091
126Metabolic pathways_Homo sapiens_hsa011000.37196830
127GABAergic synapse_Homo sapiens_hsa047270.36939441
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36854939
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.36103526
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.35493522
131Hepatitis C_Homo sapiens_hsa051600.34989857
132beta-Alanine metabolism_Homo sapiens_hsa004100.34789271
133Influenza A_Homo sapiens_hsa051640.34748968
134RNA transport_Homo sapiens_hsa030130.34405901
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34274608
136Purine metabolism_Homo sapiens_hsa002300.34224119
137N-Glycan biosynthesis_Homo sapiens_hsa005100.33274825
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.32982283
139Spliceosome_Homo sapiens_hsa030400.30105248
140FoxO signaling pathway_Homo sapiens_hsa040680.30101272
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.27890343
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26941411
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24366513
144Axon guidance_Homo sapiens_hsa043600.23900682
145Focal adhesion_Homo sapiens_hsa045100.23429134
146MicroRNAs in cancer_Homo sapiens_hsa052060.22511357
147p53 signaling pathway_Homo sapiens_hsa041150.22157063
148Basal cell carcinoma_Homo sapiens_hsa052170.21743555
149Ovarian steroidogenesis_Homo sapiens_hsa049130.21195676
150Pyrimidine metabolism_Homo sapiens_hsa002400.21125730
151mRNA surveillance pathway_Homo sapiens_hsa030150.20184649
152Thyroid cancer_Homo sapiens_hsa052160.19119511

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