PTP4A1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)8.84008634
2negative regulation of neurotransmitter transport (GO:0051589)8.76955006
3positive regulation of vasculogenesis (GO:2001214)7.81173166
4rRNA modification (GO:0000154)7.45971953
5Rap protein signal transduction (GO:0032486)7.01386610
6regulation of establishment of cell polarity (GO:2000114)6.93621503
7regulation of establishment or maintenance of cell polarity (GO:0032878)5.70036636
8positive regulation of Rap GTPase activity (GO:0032854)5.64353665
9regulation of vasculogenesis (GO:2001212)5.45197977
10auditory receptor cell stereocilium organization (GO:0060088)5.43160925
11regulation of Rap GTPase activity (GO:0032317)5.31752980
12response to nerve growth factor (GO:1990089)5.30747104
13cellular response to nerve growth factor stimulus (GO:1990090)5.30747104
14endocardial cushion development (GO:0003197)5.03814250
15negative regulation of granulocyte differentiation (GO:0030853)5.01838956
16activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.85537762
17regulation of synaptic vesicle exocytosis (GO:2000300)4.84323712
18heparin metabolic process (GO:0030202)4.30387389
19heparin biosynthetic process (GO:0030210)4.30387389
20regulation of male gonad development (GO:2000018)4.24887880
21negative regulation of norepinephrine secretion (GO:0010700)4.20535743
22photoreceptor cell maintenance (GO:0045494)4.10036772
23protein neddylation (GO:0045116)4.08878680
24DNA double-strand break processing (GO:0000729)4.05998707
25inner ear receptor stereocilium organization (GO:0060122)4.00739804
26establishment of endothelial barrier (GO:0061028)3.98617440
27positive regulation of granulocyte differentiation (GO:0030854)3.96241044
28regulation of pigment cell differentiation (GO:0050932)3.93684468
29regulation of inositol phosphate biosynthetic process (GO:0010919)3.92982445
30response to dietary excess (GO:0002021)3.90737608
31cullin deneddylation (GO:0010388)3.89930191
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87138312
33response to pheromone (GO:0019236)3.83233062
34regulation of female gonad development (GO:2000194)3.82000205
35negative regulation of heart rate (GO:0010459)3.67130510
36regulation of synaptic vesicle transport (GO:1902803)3.66967535
37negative regulation of exocytosis (GO:0045920)3.63990889
38positive regulation of male gonad development (GO:2000020)3.63067695
39peripheral nervous system neuron development (GO:0048935)3.57147684
40protein deneddylation (GO:0000338)3.56732168
41positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.54420869
42regulation of penile erection (GO:0060405)3.53689726
43hematopoietic stem cell proliferation (GO:0071425)3.42670387
44definitive hemopoiesis (GO:0060216)3.41831663
45regulation of glucokinase activity (GO:0033131)3.40788415
46regulation of hexokinase activity (GO:1903299)3.40788415
47regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.39265025
48ribonucleoprotein complex disassembly (GO:0032988)3.39218629
49phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.35956322
50tachykinin receptor signaling pathway (GO:0007217)3.31425673
51cornea development in camera-type eye (GO:0061303)3.29698274
52positive regulation of steroid hormone secretion (GO:2000833)3.25162932
53left/right pattern formation (GO:0060972)3.22354163
54negative regulation of mast cell activation (GO:0033004)3.14789360
55positive regulation of protein kinase C signaling (GO:0090037)3.14189487
56relaxation of smooth muscle (GO:0044557)3.12069115
57vocalization behavior (GO:0071625)3.11441441
58negative regulation of catecholamine secretion (GO:0033604)3.08521243
59protein-cofactor linkage (GO:0018065)3.05187950
60regulation of feeding behavior (GO:0060259)3.04750655
61negative regulation of appetite (GO:0032099)3.00992637
62negative regulation of response to food (GO:0032096)3.00992637
63regulation of developmental pigmentation (GO:0048070)3.00582900
64cellular response to arsenic-containing substance (GO:0071243)2.98501357
65positive regulation of mitochondrial fission (GO:0090141)2.98248438
66regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.96779277
67pseudouridine synthesis (GO:0001522)2.95567016
68astrocyte development (GO:0014002)2.91625572
69regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418)2.90499536
70negative regulation of cell aging (GO:0090344)2.88045812
71cranial nerve morphogenesis (GO:0021602)2.85179169
72histone H3-K4 trimethylation (GO:0080182)2.84856656
73thrombin receptor signaling pathway (GO:0070493)2.84027724
74regulation of cAMP-dependent protein kinase activity (GO:2000479)2.82206224
75imidazole-containing compound metabolic process (GO:0052803)2.81560676
76head development (GO:0060322)2.81096377
77positive regulation of receptor internalization (GO:0002092)2.80842303
78ubiquinone metabolic process (GO:0006743)2.79865019
79developmental pigmentation (GO:0048066)2.78577094
80regulation of calcium ion-dependent exocytosis (GO:0017158)2.76796112
81platelet dense granule organization (GO:0060155)2.76456694
82embryonic process involved in female pregnancy (GO:0060136)2.76231434
83deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.73752975
84ubiquinone biosynthetic process (GO:0006744)2.73702346
85positive regulation of natural killer cell differentiation (GO:0032825)2.68711536
86quinone metabolic process (GO:1901661)2.66290877
87negative regulation of chemokine production (GO:0032682)2.64590143
88negative regulation of viral entry into host cell (GO:0046597)2.63379072
89negative regulation of synaptic transmission (GO:0050805)2.62916134
90lens morphogenesis in camera-type eye (GO:0002089)2.60441851
91positive regulation of developmental pigmentation (GO:0048087)2.59056337
92left/right axis specification (GO:0070986)2.58599103
93nodal signaling pathway (GO:0038092)2.57872116
94establishment of protein localization to Golgi (GO:0072600)2.57187160
95endothelial cell development (GO:0001885)2.56450092
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.55504394
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55504394
98negative regulation of calcium ion-dependent exocytosis (GO:0045955)11.5858895
99negative regulation of neurotransmitter secretion (GO:0046929)10.2701701
100nerve growth factor signaling pathway (GO:0038180)10.2656131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.92883140
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.83767920
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.70307578
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.23224770
5ZFP57_27257070_Chip-Seq_ESCs_Mouse3.06048937
6VDR_22108803_ChIP-Seq_LS180_Human3.01412998
7ZNF274_21170338_ChIP-Seq_K562_Hela2.94339522
8EWS_26573619_Chip-Seq_HEK293_Human2.94296845
9IGF1R_20145208_ChIP-Seq_DFB_Human2.87906869
10GBX2_23144817_ChIP-Seq_PC3_Human2.56125627
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48507906
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.39355328
13FUS_26573619_Chip-Seq_HEK293_Human2.38750322
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.35472028
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.32528396
16SCL_19346495_ChIP-Seq_HPC-7_Human2.24981401
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16182415
18IRF1_19129219_ChIP-ChIP_H3396_Human2.14239599
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.04284803
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04165163
21P300_19829295_ChIP-Seq_ESCs_Human2.00451945
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.89409780
23ER_23166858_ChIP-Seq_MCF-7_Human1.86868612
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86200192
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85836018
26TAF15_26573619_Chip-Seq_HEK293_Human1.83936965
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80203193
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.77898265
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.74709779
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74277724
31TP53_18474530_ChIP-ChIP_U2OS_Human1.73206624
32FLI1_21867929_ChIP-Seq_TH2_Mouse1.70026111
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.64364857
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.62549699
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59286411
36EZH2_22144423_ChIP-Seq_EOC_Human1.55221181
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54237460
38CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54004270
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.52622060
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52274948
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51074386
42TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50098534
43RUNX2_22187159_ChIP-Seq_PCA_Human1.48897322
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48497692
45AR_25329375_ChIP-Seq_VCAP_Human1.47682792
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46924466
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44897694
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.42412190
49TCF4_23295773_ChIP-Seq_U87_Human1.42406309
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40545926
51CBP_20019798_ChIP-Seq_JUKART_Human1.40545926
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38935928
53CDX2_22108803_ChIP-Seq_LS180_Human1.38688335
54TCF4_22108803_ChIP-Seq_LS180_Human1.38385873
55P53_22387025_ChIP-Seq_ESCs_Mouse1.37459668
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35424464
57BCAT_22108803_ChIP-Seq_LS180_Human1.35054949
58JUN_21703547_ChIP-Seq_K562_Human1.31381205
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28977614
60AR_21572438_ChIP-Seq_LNCaP_Human1.28813687
61STAT3_23295773_ChIP-Seq_U87_Human1.26731159
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26078781
63KDM2B_26808549_Chip-Seq_REH_Human1.25972853
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25430127
65SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25203510
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.24404506
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.23790754
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22150974
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22150974
70SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.21491678
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20842964
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.20332739
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19326132
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17742546
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.17422958
76P300_18555785_Chip-Seq_ESCs_Mouse1.16439127
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.14799456
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.13325783
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.13126097
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.12885016
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10235651
82GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.08725094
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08438375
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06127233
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05616962
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.05324189
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05324189
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03795713
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03775482
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03048566
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.02304989
92RNF2_27304074_Chip-Seq_NSC_Mouse1.01771132
93BRD4_25478319_ChIP-Seq_HGPS_Human1.00457266
94SOX2_18555785_Chip-Seq_ESCs_Mouse0.99627808
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99451199
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97268503
97OCT4_18555785_Chip-Seq_ESCs_Mouse0.96825939
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.96698692
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95600341
100GATA1_22025678_ChIP-Seq_K562_Human0.95364194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation5.52796175
2MP0003283_abnormal_digestive_organ3.98234737
3MP0005503_abnormal_tendon_morphology3.91548945
4MP0002396_abnormal_hematopoietic_system3.61712996
5MP0000462_abnormal_digestive_system3.52138900
6MP0003279_aneurysm3.10076664
7MP0005174_abnormal_tail_pigmentation2.86081564
8MP0005645_abnormal_hypothalamus_physiol2.68230772
9MP0006054_spinal_hemorrhage2.55178128
10MP0009250_abnormal_appendicular_skeleto2.43532103
11MP0004147_increased_porphyrin_level2.42107769
12MP0004134_abnormal_chest_morphology2.37757690
13MP0009384_cardiac_valve_regurgitation2.34439308
14MP0009697_abnormal_copulation2.34359670
15MP0004133_heterotaxia2.27460165
16MP0000015_abnormal_ear_pigmentation2.25993247
17MP0003890_abnormal_embryonic-extraembry2.17374438
18MP0005275_abnormal_skin_tensile2.08377660
19MP0005409_darkened_coat_color1.93891002
20MP0003880_abnormal_central_pattern1.83916289
21MP0004215_abnormal_myocardial_fiber1.81794071
22MP0001299_abnormal_eye_distance/1.74839459
23MP0001348_abnormal_lacrimal_gland1.70803491
24MP0003122_maternal_imprinting1.69242329
25MP0005464_abnormal_platelet_physiology1.68020077
26MP0009379_abnormal_foot_pigmentation1.66645008
27MP0005623_abnormal_meninges_morphology1.63082568
28MP0004484_altered_response_of1.53888860
29MP0005646_abnormal_pituitary_gland1.50630789
30MP0008877_abnormal_DNA_methylation1.47280691
31MP0002234_abnormal_pharynx_morphology1.47048344
32MP0003724_increased_susceptibility_to1.46667575
33MP0003119_abnormal_digestive_system1.40523087
34MP0004742_abnormal_vestibular_system1.37248079
35MP0001529_abnormal_vocalization1.36314149
36MP0004808_abnormal_hematopoietic_stem1.34692080
37MP0001764_abnormal_homeostasis1.27974028
38MP0002095_abnormal_skin_pigmentation1.26018469
39MP0002938_white_spotting1.21559863
40MP0003656_abnormal_erythrocyte_physiolo1.18549396
41MP0003787_abnormal_imprinting1.13444273
42MP0005508_abnormal_skeleton_morphology1.13287410
43MP0003121_genomic_imprinting1.11750127
44MP0000778_abnormal_nervous_system1.11001857
45MP0002233_abnormal_nose_morphology1.10618430
46MP0005253_abnormal_eye_physiology1.08791071
47MP0005075_abnormal_melanosome_morpholog1.08154643
48MP0010386_abnormal_urinary_bladder1.07303298
49MP0001486_abnormal_startle_reflex1.06248455
50MP0003300_gastrointestinal_ulcer1.03622270
51MP0005551_abnormal_eye_electrophysiolog1.02416338
52MP0004885_abnormal_endolymph1.02026980
53MP0000631_abnormal_neuroendocrine_gland1.01117118
54MP0004142_abnormal_muscle_tone0.94979595
55MP0000858_altered_metastatic_potential0.94518877
56MP0006072_abnormal_retinal_apoptosis0.94426423
57MP0002734_abnormal_mechanical_nocicepti0.92901293
58MP0001270_distended_abdomen0.92568470
59MP0004270_analgesia0.92482488
60MP0000026_abnormal_inner_ear0.92227825
61MP0004084_abnormal_cardiac_muscle0.92204784
62MP0003186_abnormal_redox_activity0.91677387
63MP0001970_abnormal_pain_threshold0.90690245
64MP0002108_abnormal_muscle_morphology0.89032433
65MP0000013_abnormal_adipose_tissue0.88418679
66MP0002837_dystrophic_cardiac_calcinosis0.87758709
67MP0009780_abnormal_chondrocyte_physiolo0.87525090
68MP0000049_abnormal_middle_ear0.86839589
69MP0005266_abnormal_metabolism0.86588590
70MP0001542_abnormal_bone_strength0.86105912
71MP0002102_abnormal_ear_morphology0.85389414
72MP0008770_decreased_survivor_rate0.83995421
73MP0008058_abnormal_DNA_repair0.82526002
74MP0001963_abnormal_hearing_physiology0.81829468
75MP0005248_abnormal_Harderian_gland0.80134837
76MP0005376_homeostasis/metabolism_phenot0.79168220
77MP0002177_abnormal_outer_ear0.77510047
78MP0005379_endocrine/exocrine_gland_phen0.77477807
79MP0002751_abnormal_autonomic_nervous0.76277816
80MP0002272_abnormal_nervous_system0.76117775
81MP0001915_intracranial_hemorrhage0.75093567
82MP0003763_abnormal_thymus_physiology0.73417060
83MP0000639_abnormal_adrenal_gland0.72734724
84MP0010329_abnormal_lipoprotein_level0.72328459
85MP0002114_abnormal_axial_skeleton0.71901014
86MP0003755_abnormal_palate_morphology0.71711003
87MP0005085_abnormal_gallbladder_physiolo0.71592314
88MP0002332_abnormal_exercise_endurance0.69749437
89MP0001191_abnormal_skin_condition0.65236747
90MP0000163_abnormal_cartilage_morphology0.64210897
91MP0002116_abnormal_craniofacial_bone0.64160539
92MP0002109_abnormal_limb_morphology0.64110489
93MP0001119_abnormal_female_reproductive0.63611760
94MP0002115_abnormal_skeleton_extremities0.63080258
95MP0002113_abnormal_skeleton_development0.62713974
96MP0009053_abnormal_anal_canal0.61977135
97MP0001286_abnormal_eye_development0.61047011
98MP0002896_abnormal_bone_mineralization0.59342644
99MP0005171_absent_coat_pigmentation0.59046093
100MP0000538_abnormal_urinary_bladder0.57488047

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)6.25058229
2Homocystinuria (HP:0002156)5.79809031
3Abnormality of homocysteine metabolism (HP:0010919)5.79809031
4Abnormality of methionine metabolism (HP:0010901)5.09513833
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.09034588
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.79562726
7Methylmalonic aciduria (HP:0012120)4.62041573
8Median cleft lip (HP:0000161)4.27643747
9Attenuation of retinal blood vessels (HP:0007843)3.95852242
10Abnormality of the frontal sinuses (HP:0002687)3.94327544
11Megaloblastic anemia (HP:0001889)3.89903059
12Metaphyseal dysplasia (HP:0100255)3.84677444
13Abnormality of aspartate family amino acid metabolism (HP:0010899)3.84295408
14Atonic seizures (HP:0010819)3.81649392
15Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.70945026
16Acute myeloid leukemia (HP:0004808)3.70543220
17Chronic hepatic failure (HP:0100626)3.62279601
18Abnormality of the vitamin B12 metabolism (HP:0004341)3.59750734
19Decreased central vision (HP:0007663)3.58961748
20Bony spicule pigmentary retinopathy (HP:0007737)3.47105666
21Lower limb asymmetry (HP:0100559)3.40627560
22Long clavicles (HP:0000890)3.40110600
23Abnormality of the columella (HP:0009929)3.35901023
24Abnormality of vitamin B metabolism (HP:0004340)3.31654820
25Abnormal rod and cone electroretinograms (HP:0008323)3.27869297
26Volvulus (HP:0002580)3.10330709
27Aplasia/Hypoplasia of the tibia (HP:0005772)3.05094516
28Intrahepatic cholestasis (HP:0001406)3.03120864
29Split foot (HP:0001839)2.93388724
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88436674
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.88436674
32Genetic anticipation (HP:0003743)2.76986676
33Stomach cancer (HP:0012126)2.75041869
34Short tibia (HP:0005736)2.71944735
35Pancreatic fibrosis (HP:0100732)2.71906850
36Large earlobe (HP:0009748)2.71569308
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.67931671
38Congenital sensorineural hearing impairment (HP:0008527)2.64330040
39Nephronophthisis (HP:0000090)2.47818590
40Vitreoretinal degeneration (HP:0000655)2.46490943
41Abnormality of the costochondral junction (HP:0000919)2.43697733
42Abnormality of the renal medulla (HP:0100957)2.43647108
43Fibular hypoplasia (HP:0003038)2.41780142
44Epidermoid cyst (HP:0200040)2.38829367
45Abnormality of the corticospinal tract (HP:0002492)2.38602221
46Ulnar bowing (HP:0003031)2.38092990
47Nephroblastoma (Wilms tumor) (HP:0002667)2.27850124
48Metaphyseal cupping (HP:0003021)2.26145376
49Enlarged epiphyses (HP:0010580)2.24841106
50Tibial bowing (HP:0002982)2.20578300
51Femoral bowing (HP:0002980)2.20072904
52Abnormality of vitamin metabolism (HP:0100508)2.19684243
53Small hand (HP:0200055)2.17863082
54Embryonal renal neoplasm (HP:0011794)2.17708067
55Irregular vertebral endplates (HP:0003301)2.17295729
56Absent frontal sinuses (HP:0002688)2.17181158
57Cerebellar dysplasia (HP:0007033)2.15988610
58Arthropathy (HP:0003040)2.15290794
59Intestinal atresia (HP:0011100)2.10645924
60Abnormality of the renal cortex (HP:0011035)2.09966389
61Dicarboxylic aciduria (HP:0003215)2.03776089
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03776089
63Termporal pattern (HP:0011008)2.03273757
64Insidious onset (HP:0003587)2.03273757
65Mild short stature (HP:0003502)2.02371534
66Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01758727
67Aplasia/Hypoplasia of the fibula (HP:0006492)1.99896640
68Hypoplastic ischia (HP:0003175)1.96996203
69Conjunctival hamartoma (HP:0100780)1.96280659
70Molar tooth sign on MRI (HP:0002419)1.93892600
71Abnormality of midbrain morphology (HP:0002418)1.93892600
72Abnormality of serum amino acid levels (HP:0003112)1.93857120
73Heterochromia iridis (HP:0001100)1.91807843
74Asymmetric growth (HP:0100555)1.89229023
75Embryonal neoplasm (HP:0002898)1.88991100
76Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.87707958
77Abnormality of the epiphyses of the hand (HP:0005924)1.85440799
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.82162851
79Abnormality of the ischium (HP:0003174)1.80887857
80Ulnar claw (HP:0001178)1.80694157
81Renal cortical cysts (HP:0000803)1.80527297
82Prolonged bleeding time (HP:0003010)1.77722809
83Pancreatic cysts (HP:0001737)1.75566363
84Partial duplication of the phalanx of hand (HP:0009999)1.74543228
85Steatorrhea (HP:0002570)1.73205681
86Abnormality of the incisor (HP:0000676)1.72840449
87Venous insufficiency (HP:0005293)1.72113971
883-Methylglutaconic aciduria (HP:0003535)1.71817941
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71447733
90Short 4th metacarpal (HP:0010044)1.71447733
91Generalized tonic-clonic seizures (HP:0002069)1.69689346
92Progressive macrocephaly (HP:0004481)1.68588382
93Thickened calvaria (HP:0002684)1.67892096
94Prominent nose (HP:0000448)1.67878854
95Genu varum (HP:0002970)1.67829329
96Irregular epiphyses (HP:0010582)1.67322444
97Flat face (HP:0012368)1.66896293
98Facial hemangioma (HP:0000329)1.65195028
99Focal seizures (HP:0007359)1.65117558
100Abnormality of the fibula (HP:0002991)1.64525713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK33.65179784
2PIK3CG3.47034526
3BCR3.36013762
4TRIM283.24232664
5RPS6KA43.09094817
6SIK32.91733821
7CDK82.67959467
8MAP2K72.65829768
9STK162.47298772
10CDK62.22409169
11HIPK22.14143391
12MAP3K41.99383535
13BMPR1B1.94656171
14BUB11.89096082
15SGK21.88043650
16CSNK1G21.84819018
17FRK1.84578499
18MATK1.83327489
19KSR11.83205130
20MAP3K61.79186160
21FER1.78503469
22PIK3CA1.72577273
23WNK31.62317777
24PRKG21.49643401
25MAPK131.46052015
26KIT1.42161596
27SGK4941.36122625
28SGK2231.36122625
29CSNK1G31.33400557
30TNIK1.31842265
31ACVR1B1.23685004
32NTRK31.20410935
33AKT31.20140332
34MAP3K31.18644542
35PDGFRA1.18064659
36CSNK1G11.17516663
37EPHA31.16739348
38EPHA41.16700577
39CDK31.13559152
40CASK1.07223590
41CDK91.06736900
42CAMK41.04743228
43TXK1.00867959
44PRKG10.99539992
45NEK20.98702796
46MAP3K50.93420152
47CAMKK20.90340074
48RAF10.89647579
49JAK10.87703797
50PLK40.87048052
51NUAK10.86696378
52STK390.86295182
53WNK40.84842143
54CAMK1G0.82055148
55CSNK1A1L0.78685226
56SRPK10.75547428
57PNCK0.74250497
58ADRBK20.72838257
59DYRK1A0.68691988
60PRKCE0.68576554
61SGK30.68112101
62MARK10.65644230
63TEC0.65080796
64PLK20.64516844
65MAP3K70.64111246
66CDC70.62732011
67MAP2K40.62633890
68MAP4K20.60927472
69ERBB30.58863543
70STK30.57558011
71TGFBR10.56800923
72WNK10.53245107
73PINK10.52561368
74RET0.51718329
75GSK3A0.50983005
76PKN10.50416316
77RPS6KA50.49174431
78CAMK1D0.46319257
79TYRO30.45818267
80VRK10.45086444
81MINK10.44711566
82PRKACG0.43738112
83BRD40.41022102
84MKNK10.38160220
85CAMK10.36103570
86PRKACA0.35628985
87SGK10.35579805
88OBSCN0.34973758
89NEK60.34302066
90GRK60.33692176
91MAP3K20.31900225
92RPS6KA60.30369389
93KSR20.28958563
94PDGFRB0.27367995
95RPS6KL10.27301953
96RPS6KC10.27301953
97SCYL20.26999696
98RPS6KA20.26510800
99CSNK1A10.26317651
100EIF2AK30.25147176

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.00984615
2Protein export_Homo sapiens_hsa030603.39618241
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.20393136
4Dorso-ventral axis formation_Homo sapiens_hsa043202.48098332
5Phototransduction_Homo sapiens_hsa047442.44891587
6Taste transduction_Homo sapiens_hsa047422.33384162
7Platelet activation_Homo sapiens_hsa046112.20783257
8Steroid biosynthesis_Homo sapiens_hsa001002.17800763
9Circadian entrainment_Homo sapiens_hsa047131.94659642
10Long-term potentiation_Homo sapiens_hsa047201.85361453
11Hedgehog signaling pathway_Homo sapiens_hsa043401.83117038
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82709747
13Renin secretion_Homo sapiens_hsa049241.75950035
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74984534
15Long-term depression_Homo sapiens_hsa047301.72424703
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70635657
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70184677
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58458078
19Salivary secretion_Homo sapiens_hsa049701.51843627
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41760905
21Gap junction_Homo sapiens_hsa045401.33536786
22Melanoma_Homo sapiens_hsa052181.31284587
23Renal cell carcinoma_Homo sapiens_hsa052111.26122762
24Cocaine addiction_Homo sapiens_hsa050301.23311218
25Serotonergic synapse_Homo sapiens_hsa047261.20621180
26Basal transcription factors_Homo sapiens_hsa030221.20615238
27Oxidative phosphorylation_Homo sapiens_hsa001901.14663009
28Dopaminergic synapse_Homo sapiens_hsa047281.14617546
29Ras signaling pathway_Homo sapiens_hsa040141.10475606
30Parkinsons disease_Homo sapiens_hsa050121.10404357
31Cholinergic synapse_Homo sapiens_hsa047251.10093174
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09434967
33Insulin secretion_Homo sapiens_hsa049111.03553874
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03084351
35Melanogenesis_Homo sapiens_hsa049161.00979887
36Caffeine metabolism_Homo sapiens_hsa002320.98169144
37One carbon pool by folate_Homo sapiens_hsa006700.96417943
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.95700398
39Vascular smooth muscle contraction_Homo sapiens_hsa042700.95419511
40cAMP signaling pathway_Homo sapiens_hsa040240.95363844
41Olfactory transduction_Homo sapiens_hsa047400.95165532
42Circadian rhythm_Homo sapiens_hsa047100.95021416
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94019658
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93206377
45Pancreatic secretion_Homo sapiens_hsa049720.92564825
46Oocyte meiosis_Homo sapiens_hsa041140.92315591
47Amphetamine addiction_Homo sapiens_hsa050310.91979341
48Sulfur metabolism_Homo sapiens_hsa009200.86333445
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83753524
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83080804
51Acute myeloid leukemia_Homo sapiens_hsa052210.83042468
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.82322472
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80638679
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79820957
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.79616404
56Linoleic acid metabolism_Homo sapiens_hsa005910.75546150
57Amoebiasis_Homo sapiens_hsa051460.75312084
58Collecting duct acid secretion_Homo sapiens_hsa049660.74666453
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.74225217
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72999261
61Butanoate metabolism_Homo sapiens_hsa006500.72776307
62Chronic myeloid leukemia_Homo sapiens_hsa052200.71172191
63Estrogen signaling pathway_Homo sapiens_hsa049150.71057846
64Glutamatergic synapse_Homo sapiens_hsa047240.70396267
65Glioma_Homo sapiens_hsa052140.70070935
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.69244971
67Chemokine signaling pathway_Homo sapiens_hsa040620.66600753
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66243315
69Focal adhesion_Homo sapiens_hsa045100.64181955
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63959001
71Oxytocin signaling pathway_Homo sapiens_hsa049210.62849201
72Prolactin signaling pathway_Homo sapiens_hsa049170.62058938
73Basal cell carcinoma_Homo sapiens_hsa052170.61994497
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61953880
75African trypanosomiasis_Homo sapiens_hsa051430.60516432
76Alcoholism_Homo sapiens_hsa050340.59470678
77p53 signaling pathway_Homo sapiens_hsa041150.59263714
78Type II diabetes mellitus_Homo sapiens_hsa049300.58932468
79Fatty acid elongation_Homo sapiens_hsa000620.58600458
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57564575
81Thyroid hormone synthesis_Homo sapiens_hsa049180.54656698
82Rap1 signaling pathway_Homo sapiens_hsa040150.53667282
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53293718
84Alzheimers disease_Homo sapiens_hsa050100.53091046
85Peroxisome_Homo sapiens_hsa041460.53060476
86Protein digestion and absorption_Homo sapiens_hsa049740.51154946
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50580944
88Chemical carcinogenesis_Homo sapiens_hsa052040.50400291
89Morphine addiction_Homo sapiens_hsa050320.50383887
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50068855
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48475210
92Ovarian steroidogenesis_Homo sapiens_hsa049130.45341785
93Glycerolipid metabolism_Homo sapiens_hsa005610.44783560
94ECM-receptor interaction_Homo sapiens_hsa045120.44513229
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44404151
96Glucagon signaling pathway_Homo sapiens_hsa049220.42548497
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41792850
98Wnt signaling pathway_Homo sapiens_hsa043100.41579347
99Huntingtons disease_Homo sapiens_hsa050160.41406432
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39638182

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