PTP4A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.67162982
2heart process (GO:0003015)4.36967016
3heart contraction (GO:0060047)4.36967016
4negative regulation of erythrocyte differentiation (GO:0045647)4.31415675
5positive regulation of granulocyte differentiation (GO:0030854)4.19397397
6regulation of histone H3-K27 methylation (GO:0061085)4.05211960
7kinetochore organization (GO:0051383)3.98878592
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.97879739
9regulation of B cell receptor signaling pathway (GO:0050855)3.83304770
10muscle filament sliding (GO:0030049)3.69335030
11actin-myosin filament sliding (GO:0033275)3.69335030
12mitotic metaphase plate congression (GO:0007080)3.67208017
13CENP-A containing nucleosome assembly (GO:0034080)3.63944662
14neutrophil activation involved in immune response (GO:0002283)3.49268933
15IMP biosynthetic process (GO:0006188)3.46691795
16nuclear pore complex assembly (GO:0051292)3.43179121
17chromatin remodeling at centromere (GO:0031055)3.41110376
18kinetochore assembly (GO:0051382)3.40772556
19nuclear pore organization (GO:0006999)3.38845528
20actin-mediated cell contraction (GO:0070252)3.37079531
21membrane raft organization (GO:0031579)3.35183057
22mitotic sister chromatid cohesion (GO:0007064)3.30989570
23B cell receptor signaling pathway (GO:0050853)3.26094737
24megakaryocyte development (GO:0035855)3.25997940
25regulation of gamma-delta T cell differentiation (GO:0045586)3.23552396
26regulation of gamma-delta T cell activation (GO:0046643)3.23467114
27regulation of RNA export from nucleus (GO:0046831)3.22574513
28metaphase plate congression (GO:0051310)3.20549765
29telomere maintenance via recombination (GO:0000722)3.19244429
30negative T cell selection (GO:0043383)3.18114809
31negative thymic T cell selection (GO:0045060)3.16654576
32positive T cell selection (GO:0043368)3.16170263
33purine nucleobase biosynthetic process (GO:0009113)3.15269261
34mitotic recombination (GO:0006312)3.14022545
35positive thymic T cell selection (GO:0045059)3.13617491
36establishment of chromosome localization (GO:0051303)3.13131492
37definitive hemopoiesis (GO:0060216)3.08969505
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08177078
39regulation of mitotic spindle checkpoint (GO:1903504)3.08177078
40IMP metabolic process (GO:0046040)3.06427259
41pore complex assembly (GO:0046931)3.06410033
42regulation of nucleobase-containing compound transport (GO:0032239)3.05957826
43DNA replication checkpoint (GO:0000076)3.04519434
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01930395
45Rap protein signal transduction (GO:0032486)3.01037331
46hypotonic response (GO:0006971)3.00555266
47T cell selection (GO:0045058)2.98162983
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97143819
49DNA replication-independent nucleosome assembly (GO:0006336)2.96727157
50DNA replication-independent nucleosome organization (GO:0034724)2.96727157
51mitotic chromosome condensation (GO:0007076)2.96703254
52ribosomal small subunit assembly (GO:0000028)2.95505350
53telomere maintenance via semi-conservative replication (GO:0032201)2.93142351
54DNA unwinding involved in DNA replication (GO:0006268)2.92520690
55negative regulation of striated muscle cell apoptotic process (GO:0010664)2.89724041
56phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89566593
57regulation of spindle organization (GO:0090224)2.87382246
58RNA-dependent DNA replication (GO:0006278)2.85313944
59DNA strand elongation involved in DNA replication (GO:0006271)2.84536296
60nucleobase biosynthetic process (GO:0046112)2.84465672
61positive regulation of B cell differentiation (GO:0045579)2.83981611
62cytoplasmic mRNA processing body assembly (GO:0033962)2.82643237
63mitotic nuclear envelope disassembly (GO:0007077)2.81873617
64peptidyl-threonine modification (GO:0018210)2.81594511
65meiotic chromosome segregation (GO:0045132)2.81393093
66DNA strand elongation (GO:0022616)2.78358889
67histone exchange (GO:0043486)2.77539648
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77213473
69negative regulation of cell killing (GO:0031342)2.77213473
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77154310
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.77154310
72modulation by symbiont of host immune response (GO:0052553)2.77154310
73positive regulation by symbiont of host defense response (GO:0052509)2.77154310
74modulation by symbiont of host defense response (GO:0052031)2.77154310
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77154310
76corticosteroid receptor signaling pathway (GO:0031958)2.76715989
77positive regulation of mast cell activation (GO:0033005)2.76178348
78peptidyl-threonine phosphorylation (GO:0018107)2.75664068
79thymic T cell selection (GO:0045061)2.73719539
80glucocorticoid receptor signaling pathway (GO:0042921)2.73570380
81protein localization to kinetochore (GO:0034501)2.72154272
82viral mRNA export from host cell nucleus (GO:0046784)2.70810517
83response to peptidoglycan (GO:0032494)2.70349702
84histone H3-K4 trimethylation (GO:0080182)2.68659088
85antigen processing and presentation via MHC class Ib (GO:0002475)2.68165357
86establishment of endothelial barrier (GO:0061028)2.67776556
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67686821
88negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.67658782
89regulation of early endosome to late endosome transport (GO:2000641)2.66983902
90regulation of granulocyte differentiation (GO:0030852)2.66953742
91JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65690941
92protein localization to chromosome, centromeric region (GO:0071459)2.64994729
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64763328
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.64763328
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64763328
96regulation of double-strand break repair via homologous recombination (GO:0010569)2.64120033
97embryonic process involved in female pregnancy (GO:0060136)2.63234052
98spindle checkpoint (GO:0031577)2.62734503
99mitotic G2/M transition checkpoint (GO:0044818)2.62558215
100negative regulation of dendrite morphogenesis (GO:0050774)2.60761838
101positive regulation of Rap GTPase activity (GO:0032854)2.58721143
102negative regulation of phagocytosis (GO:0050765)2.57615525
103attachment of spindle microtubules to kinetochore (GO:0008608)2.56088486
104formation of translation preinitiation complex (GO:0001731)2.55690149
105cortical actin cytoskeleton organization (GO:0030866)2.54883477
106cullin deneddylation (GO:0010388)2.54636636
1073-UTR-mediated mRNA stabilization (GO:0070935)2.54206993
108ATP-dependent chromatin remodeling (GO:0043044)2.52699788
109antigen processing and presentation of endogenous antigen (GO:0019883)2.52342127
110membrane disassembly (GO:0030397)2.51476586
111nuclear envelope disassembly (GO:0051081)2.51476586
112telomere maintenance (GO:0000723)2.49674361
113response to interleukin-15 (GO:0070672)2.48958902
114T cell costimulation (GO:0031295)2.48942014
115telomere maintenance via telomere lengthening (GO:0010833)2.48774497
116positive regulation of macrophage differentiation (GO:0045651)2.48130799
117actin filament-based movement (GO:0030048)2.47901164
118DNA replication initiation (GO:0006270)2.47136277
119telomere organization (GO:0032200)2.46571804
120regulation of platelet aggregation (GO:0090330)2.45976878
121positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45381959
122positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.45186390
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44575157
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44574487
125lymphocyte costimulation (GO:0031294)2.44444761
126DNA double-strand break processing (GO:0000729)2.44159609
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43855369
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.43514330
129regulation of mast cell degranulation (GO:0043304)2.43302209
130oxidative phosphorylation (GO:0006119)2.43164814
131mitotic G2 DNA damage checkpoint (GO:0007095)2.42592946
132protein deneddylation (GO:0000338)2.42464074
133cellular extravasation (GO:0045123)2.42311991
134nerve growth factor signaling pathway (GO:0038180)2.41450233
135maturation of 5.8S rRNA (GO:0000460)2.41386601
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.41365532
137leukocyte aggregation (GO:0070486)2.41062694
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41029878
139localization within membrane (GO:0051668)2.40769307
140positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.40765892
141transcription-coupled nucleotide-excision repair (GO:0006283)2.40686273
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.40523806
143somatic hypermutation of immunoglobulin genes (GO:0016446)2.40523806
144antigen receptor-mediated signaling pathway (GO:0050851)2.40353554
145mucosal-associated lymphoid tissue development (GO:0048537)2.39400841
146Peyers patch development (GO:0048541)2.39400841
147monoubiquitinated protein deubiquitination (GO:0035520)2.38237846
148regulation of B cell differentiation (GO:0045577)2.37639925
149regulation of nuclear cell cycle DNA replication (GO:0033262)2.37447274
150proteasome assembly (GO:0043248)2.37037029
151positive regulation of leukocyte degranulation (GO:0043302)2.36427665
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.36223694
153DNA topological change (GO:0006265)2.36177149
154negative regulation of skeletal muscle tissue development (GO:0048642)2.35781369
155regulation of alpha-beta T cell proliferation (GO:0046640)2.35644235
156mitotic spindle checkpoint (GO:0071174)2.34754342
157positive regulation of mast cell degranulation (GO:0043306)2.34160825
158positive regulation of mast cell activation involved in immune response (GO:0033008)2.34160825
159DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.33561676
160transcription initiation from RNA polymerase I promoter (GO:0006361)2.33456805
161cardiac right ventricle morphogenesis (GO:0003215)2.33235160
162signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.33174302
163signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.33174302
164signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.33174302
165hepatocyte apoptotic process (GO:0097284)2.32823203
166regulation of defense response to virus by virus (GO:0050690)2.32782827
167regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.32587310
168SMAD protein complex assembly (GO:0007183)2.32045109
169replication fork processing (GO:0031297)2.31985682
170natural killer cell differentiation (GO:0001779)2.31293082
171antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.30855322
172cardiac muscle tissue morphogenesis (GO:0055008)2.30782553
173G1/S transition of mitotic cell cycle (GO:0000082)2.30598342
174cell cycle G1/S phase transition (GO:0044843)2.30598342
175mitotic sister chromatid segregation (GO:0000070)2.29513643
176signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.29503392
177intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.29503392
178regulation of mitotic spindle organization (GO:0060236)2.29254292
179negative regulation of T cell mediated immunity (GO:0002710)2.29230445
180paraxial mesoderm development (GO:0048339)2.29145122
181negative regulation of protein localization to plasma membrane (GO:1903077)2.29074848
182sarcomere organization (GO:0045214)2.28395814
183histone phosphorylation (GO:0016572)2.28159080
184macrophage activation involved in immune response (GO:0002281)2.27782471
185detection of molecule of bacterial origin (GO:0032490)2.27042659
186detection of other organism (GO:0098543)2.26832192
187T cell receptor signaling pathway (GO:0050852)2.26814902
188regulation of leukocyte degranulation (GO:0043300)2.26766630
189regulation of mast cell activation involved in immune response (GO:0033006)2.25583063
190myeloid cell development (GO:0061515)2.25470709
191protein export from nucleus (GO:0006611)2.25388642
192T cell homeostasis (GO:0043029)2.22009444
193germinal center formation (GO:0002467)2.21865461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.25399883
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.10568310
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62283761
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.47694401
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.28659224
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24554947
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21843624
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.04032711
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.78639465
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64896510
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63220367
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62594543
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.61820514
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61165639
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60108326
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.58281984
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.51886571
18ELK1_19687146_ChIP-ChIP_HELA_Human2.50299265
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50090409
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39818714
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.37998364
22SCL_19346495_ChIP-Seq_HPC-7_Human2.37603814
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37182188
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36265888
25AR_21909140_ChIP-Seq_LNCAP_Human2.32148165
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30828623
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26695771
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24126549
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.23734510
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20843464
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11916708
32RUNX_20019798_ChIP-Seq_JUKART_Human2.11755573
33RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10639808
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07178687
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03988384
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.99431189
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96553037
38VDR_23849224_ChIP-Seq_CD4+_Human1.96382908
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.96051039
40* MYB_26560356_Chip-Seq_TH1_Human1.92380827
41GATA1_22025678_ChIP-Seq_K562_Human1.90153250
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88349828
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88102462
44* TCF7_22412390_ChIP-Seq_EML_Mouse1.86673109
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86603049
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85300763
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.85090679
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84163372
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83632856
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.82415206
51SPI1_23127762_ChIP-Seq_K562_Human1.79225402
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75656027
53* MAF_26560356_Chip-Seq_TH1_Human1.74738127
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72606772
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71815024
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.70116185
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.69451617
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67707535
59FOXP3_21729870_ChIP-Seq_TREG_Human1.64589940
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59727927
61DCP1A_22483619_ChIP-Seq_HELA_Human1.56775765
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56722944
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55605575
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55577320
65XRN2_22483619_ChIP-Seq_HELA_Human1.55280847
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54490833
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50071923
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49787281
69GATA1_19941826_ChIP-Seq_K562_Human1.48882649
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.48798018
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47527575
72* VDR_24763502_ChIP-Seq_THP-1_Human1.47078784
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46732786
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44687707
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.43662501
76* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42802233
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40836543
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39653139
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38770911
80* GATA2_19941826_ChIP-Seq_K562_Human1.37842594
81* TTF2_22483619_ChIP-Seq_HELA_Human1.36396954
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35654166
83* UTX_26944678_Chip-Seq_JUKART_Human1.35492108
84* ESR1_20079471_ChIP-ChIP_T-47D_Human1.35251152
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34653022
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34367401
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34041881
88CLOCK_20551151_ChIP-Seq_293T_Human1.32721911
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32063801
90VDR_21846776_ChIP-Seq_THP-1_Human1.31611218
91CIITA_25753668_ChIP-Seq_RAJI_Human1.31511103
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30883361
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30815766
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.30799970
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30075113
96* PU_27001747_Chip-Seq_BMDM_Mouse1.29004721
97GABP_19822575_ChIP-Seq_HepG2_Human1.28566460
98GATA4_21415370_ChIP-Seq_HL-1_Mouse1.27587480
99* NCOR1_26117541_ChIP-Seq_K562_Human1.26190650
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25175953
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24913646
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23179594
103* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22678771
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21822698
105* KDM2B_26808549_Chip-Seq_DND41_Human1.20811289
106* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20226168
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.19449666
108* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17466936
109* KDM2B_26808549_Chip-Seq_JURKAT_Human1.15257829
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.14908513
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14400332
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13151294
113* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12968801
114* SPI1_23547873_ChIP-Seq_NB4_Human1.12923920
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12322419
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11628226
117STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10979900
118* GATA3_27048872_Chip-Seq_THYMUS_Human1.10634942
119* BRD4_25478319_ChIP-Seq_HGPS_Human1.09562319
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09256371
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09226808
122* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08419546
123KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08010717
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07752401
125VDR_24787735_ChIP-Seq_THP-1_Human1.07689684
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07024575
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06364916
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.06266438
129CHD1_26751641_Chip-Seq_LNCaP_Human1.06087281
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04308554
131* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03418659
132KDM5A_27292631_Chip-Seq_BREAST_Human1.03406614
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03124329
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01930615
135* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01622488
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01022558
137* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00688728
138THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99801531
139* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99581521
140RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99344951
141* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99154784
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97369241
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97098598
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.96623322
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95071305
146* MAF_26560356_Chip-Seq_TH2_Human0.95041135
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94785374
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94765934
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94738795
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.94492056
151ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94156063
152* ELK3_25401928_ChIP-Seq_HUVEC_Human0.93866657
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93540177
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93535299
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93113284
156* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91318709
157TFEB_21752829_ChIP-Seq_HELA_Human0.89786624
158* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87099009
159YY1_21170310_ChIP-Seq_MESCs_Mouse0.86291890
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85728493
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85728493
162EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85679779
163NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84673400
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84638762
165* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84220216
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81390141
167* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80968516
168MYC_22102868_ChIP-Seq_BL_Human0.80620620
169* MYB_26560356_Chip-Seq_TH2_Human0.80345111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.10101215
2MP0003693_abnormal_embryo_hatching2.88585068
3MP0008007_abnormal_cellular_replicative2.80498106
4MP0003300_gastrointestinal_ulcer2.68014749
5MP0010094_abnormal_chromosome_stability2.61921686
6MP0003077_abnormal_cell_cycle2.51894085
7MP0005464_abnormal_platelet_physiology2.50974608
8MP0002166_altered_tumor_susceptibility2.39173674
9MP0003111_abnormal_nucleus_morphology2.31303227
10MP0008057_abnormal_DNA_replication2.21794901
11MP0003123_paternal_imprinting2.20600374
12MP0003705_abnormal_hypodermis_morpholog2.14004493
13MP0004957_abnormal_blastocyst_morpholog2.09949253
14MP0008058_abnormal_DNA_repair2.00439942
15MP0003567_abnormal_fetal_cardiomyocyte2.00065522
16MP0000685_abnormal_immune_system1.86606990
17MP0003121_genomic_imprinting1.83005720
18MP0000749_muscle_degeneration1.82918100
19MP0000703_abnormal_thymus_morphology1.76406325
20MP0003091_abnormal_cell_migration1.75103709
21MP0004185_abnormal_adipocyte_glucose1.68422120
22MP0002396_abnormal_hematopoietic_system1.67569795
23MP0001800_abnormal_humoral_immune1.66492377
24MP0003941_abnormal_skin_development1.66019536
25MP0003436_decreased_susceptibility_to1.65891345
26MP0002006_tumorigenesis1.65324937
27MP0008438_abnormal_cutaneous_collagen1.62979458
28MP0005408_hypopigmentation1.61974006
29MP0005000_abnormal_immune_tolerance1.58778912
30MP0004808_abnormal_hematopoietic_stem1.58502012
31MP0003950_abnormal_plasma_membrane1.56050758
32MP0001835_abnormal_antigen_presentation1.55998537
33MP0004084_abnormal_cardiac_muscle1.53587226
34MP0003656_abnormal_erythrocyte_physiolo1.52030962
35MP0003828_pulmonary_edema1.51312561
36MP0009053_abnormal_anal_canal1.50888058
37MP0003303_peritoneal_inflammation1.50330821
38MP0002420_abnormal_adaptive_immunity1.44694957
39MP0003786_premature_aging1.44529922
40MP0008932_abnormal_embryonic_tissue1.44051827
41MP0004947_skin_inflammation1.43662790
42MP0003279_aneurysm1.42797353
43MP0001819_abnormal_immune_cell1.41224871
44MP0005076_abnormal_cell_differentiation1.40371455
45MP0000350_abnormal_cell_proliferation1.39647895
46MP0009697_abnormal_copulation1.39481547
47MP0002419_abnormal_innate_immunity1.38769327
48MP0003724_increased_susceptibility_to1.37357002
49MP0001730_embryonic_growth_arrest1.36814253
50MP0000516_abnormal_urinary_system1.35987147
51MP0005367_renal/urinary_system_phenotyp1.35987147
52MP0005409_darkened_coat_color1.35921416
53MP0002088_abnormal_embryonic_growth/wei1.35257952
54MP0002723_abnormal_immune_serum1.34296499
55MP0003984_embryonic_growth_retardation1.33968666
56MP0001851_eye_inflammation1.33286154
57MP0000716_abnormal_immune_system1.33170196
58MP0003221_abnormal_cardiomyocyte_apopto1.32978721
59MP0003315_abnormal_perineum_morphology1.31989158
60MP0005503_abnormal_tendon_morphology1.31842967
61MP0010030_abnormal_orbit_morphology1.31587507
62MP0001672_abnormal_embryogenesis/_devel1.31347631
63MP0005380_embryogenesis_phenotype1.31347631
64MP0008260_abnormal_autophagy1.31304324
65MP0003186_abnormal_redox_activity1.30957653
66MP0001790_abnormal_immune_system1.28883566
67MP0005387_immune_system_phenotype1.28883566
68MP0008877_abnormal_DNA_methylation1.27479697
69MP0002429_abnormal_blood_cell1.23839891
70MP0003763_abnormal_thymus_physiology1.22311841
71MP0003943_abnormal_hepatobiliary_system1.21956558
72MP0010155_abnormal_intestine_physiology1.20448906
73MP0002405_respiratory_system_inflammati1.19599158
74MP0003045_fibrosis1.18385038
75MP0010234_abnormal_vibrissa_follicle1.17318369
76MP0003191_abnormal_cellular_cholesterol1.14715175
77MP0002972_abnormal_cardiac_muscle1.13832465
78MP0005666_abnormal_adipose_tissue1.13446477
79MP0005451_abnormal_body_composition1.13014612
80MP0009333_abnormal_splenocyte_physiolog1.12105002
81MP0001697_abnormal_embryo_size1.11481486
82MP0000569_abnormal_digit_pigmentation1.11030656
83MP0004381_abnormal_hair_follicle1.10554492
84MP0005025_abnormal_response_to1.10225504
85MP0002132_abnormal_respiratory_system1.09512604
86MP0010630_abnormal_cardiac_muscle1.08990631
87MP0003942_abnormal_urinary_system1.07743002
88MP0001879_abnormal_lymphatic_vessel1.07714889
89MP0000015_abnormal_ear_pigmentation1.07157597
90MP0001873_stomach_inflammation1.05879464
91MP0003122_maternal_imprinting1.04939496
92MP0002998_abnormal_bone_remodeling1.04807914
93MP0004233_abnormal_muscle_weight1.04439533
94MP0003718_maternal_effect1.04386932
95MP0004197_abnormal_fetal_growth/weight/1.04213595
96MP0006054_spinal_hemorrhage1.03328259
97MP0010352_gastrointestinal_tract_polyps1.03143526
98MP0008789_abnormal_olfactory_epithelium1.02454760
99MP0005621_abnormal_cell_physiology1.02149162
100MP0001119_abnormal_female_reproductive1.01381498
101MP0000490_abnormal_crypts_of1.01337462
102MP0000767_abnormal_smooth_muscle1.01263249
103MP0002086_abnormal_extraembryonic_tissu1.00671400
104MP0006082_CNS_inflammation0.98810325
105MP0003448_altered_tumor_morphology0.97947067
106MP0000343_altered_response_to0.97702118
107MP0001544_abnormal_cardiovascular_syste0.97519512
108MP0005385_cardiovascular_system_phenoty0.97519512
109MP0003115_abnormal_respiratory_system0.97104086
110MP0003385_abnormal_body_wall0.96037016
111MP0000566_synostosis0.95330551
112MP0001545_abnormal_hematopoietic_system0.95224569
113MP0005397_hematopoietic_system_phenotyp0.95224569
114MP0005671_abnormal_response_to0.94303414
115MP0004782_abnormal_surfactant_physiolog0.94145180
116MP0009250_abnormal_appendicular_skeleto0.93329211
117MP0000313_abnormal_cell_death0.93200827
118MP0002148_abnormal_hypersensitivity_rea0.92942508
119MP0005023_abnormal_wound_healing0.92070701
120MP0002398_abnormal_bone_marrow0.90913217
121MP0004510_myositis0.90886448
122MP0002019_abnormal_tumor_incidence0.90644081
123MP0009785_altered_susceptibility_to0.89582945
124MP0004130_abnormal_muscle_cell0.88058968
125MP0003566_abnormal_cell_adhesion0.87229080
126MP0001853_heart_inflammation0.87002629
127MP0009384_cardiac_valve_regurgitation0.86982144
128MP0001915_intracranial_hemorrhage0.86720292
129MP0003866_abnormal_defecation0.86669210
130MP0010307_abnormal_tumor_latency0.86569790
131MP0000689_abnormal_spleen_morphology0.86373927
132MP0004883_abnormal_blood_vessel0.86343182
133MP0005620_abnormal_muscle_contractility0.86047966
134MP0004087_abnormal_muscle_fiber0.86018315
135MP0002009_preneoplasia0.83910323
136MP0002085_abnormal_embryonic_tissue0.82223856
137MP0002452_abnormal_antigen_presenting0.82180326
138MP0000465_gastrointestinal_hemorrhage0.82176614
139MP0003937_abnormal_limbs/digits/tail_de0.82124314
140MP0002080_prenatal_lethality0.81955656
141MP0005275_abnormal_skin_tensile0.81918038
142MP0004036_abnormal_muscle_relaxation0.81627888
143MP0009115_abnormal_fat_cell0.81140036
144MP0005083_abnormal_biliary_tract0.80500738
145MP0002722_abnormal_immune_system0.80048823
146MP0002933_joint_inflammation0.79535776
147MP0005248_abnormal_Harderian_gland0.79481082
148MP0001845_abnormal_inflammatory_respons0.79473279
149MP0005330_cardiomyopathy0.79401729
150MP0010368_abnormal_lymphatic_system0.79375297
151MP0000858_altered_metastatic_potential0.79185606
152MP0001348_abnormal_lacrimal_gland0.78521299
153MP0003453_abnormal_keratinocyte_physiol0.77872889
154MP0004484_altered_response_of0.77481770
155MP0005058_abnormal_lysosome_morphology0.76640307
156MP0005508_abnormal_skeleton_morphology0.75874602
157MP0000733_abnormal_muscle_development0.75733188
158MP0009672_abnormal_birth_weight0.75601656

Predicted human phenotypes

RankGene SetZ-score
1Syringomyelia (HP:0003396)3.99463175
2Spinal cord lesions (HP:0100561)3.99463175
3Degeneration of anterior horn cells (HP:0002398)3.68107375
4Abnormality of the anterior horn cell (HP:0006802)3.68107375
5Fatigue (HP:0012378)3.35321287
6Prolonged bleeding time (HP:0003010)3.13079262
7Birth length less than 3rd percentile (HP:0003561)3.03202222
8Exercise-induced muscle cramps (HP:0003710)3.03160337
9Ankyloglossia (HP:0010296)2.96283700
10Osteolytic defects of the hand bones (HP:0009699)2.89517006
11Osteolytic defects of the phalanges of the hand (HP:0009771)2.89517006
12T lymphocytopenia (HP:0005403)2.87436339
13Abnormal platelet volume (HP:0011876)2.85627056
14Spontaneous hematomas (HP:0007420)2.84658481
15Asymmetry of the thorax (HP:0001555)2.80148770
16Nemaline bodies (HP:0003798)2.79437912
17Increased mean platelet volume (HP:0011877)2.77283016
18Abnormality of T cell number (HP:0011839)2.71979499
19Recurrent viral infections (HP:0004429)2.67997880
20Abnormality of the left ventricular outflow tract (HP:0011103)2.67261171
21Subaortic stenosis (HP:0001682)2.67261171
22Autoimmune hemolytic anemia (HP:0001890)2.67058671
23Eczematoid dermatitis (HP:0000976)2.57738418
24Abnormal lung lobation (HP:0002101)2.55413167
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.55301126
26Aplasia/Hypoplasia of the patella (HP:0006498)2.52718741
27Patellar aplasia (HP:0006443)2.50745481
28Macroorchidism (HP:0000053)2.48698734
29Cutaneous melanoma (HP:0012056)2.47770133
30Deep philtrum (HP:0002002)2.46769338
31Muscle fiber inclusion bodies (HP:0100299)2.46277112
32Abnormality of oral frenula (HP:0000190)2.45379511
33Polycythemia (HP:0001901)2.43891192
34Epistaxis (HP:0000421)2.43077380
35Hyporeflexia of lower limbs (HP:0002600)2.42803153
36Abnormality of incisor morphology (HP:0011063)2.40638749
37Long clavicles (HP:0000890)2.37894333
38Embryonal renal neoplasm (HP:0011794)2.34733452
39Menorrhagia (HP:0000132)2.32712263
40Nephroblastoma (Wilms tumor) (HP:0002667)2.31953674
41Granulocytopenia (HP:0001913)2.30445727
42Papilledema (HP:0001085)2.28549280
43Cellulitis (HP:0100658)2.28482018
44Recurrent abscess formation (HP:0002722)2.27892641
45Abnormal platelet function (HP:0011869)2.20972124
46Impaired platelet aggregation (HP:0003540)2.20972124
47Panhypogammaglobulinemia (HP:0003139)2.19998667
48Pulmonary artery stenosis (HP:0004415)2.19000872
49Dilatation of the ascending aorta (HP:0005111)2.18594894
5011 pairs of ribs (HP:0000878)2.18284839
51Slow saccadic eye movements (HP:0000514)2.17586213
52Calf muscle hypertrophy (HP:0008981)2.16936108
53Diastasis recti (HP:0001540)2.16618594
54Viral hepatitis (HP:0006562)2.16586669
55Osteomyelitis (HP:0002754)2.16419448
56Recurrent bacterial skin infections (HP:0005406)2.14928978
57Ectopic kidney (HP:0000086)2.14852082
58Gingival bleeding (HP:0000225)2.13739615
59Relative macrocephaly (HP:0004482)2.12703737
60Spondylolisthesis (HP:0003302)2.12252611
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.11985093
62Abnormality of skeletal muscle fiber size (HP:0012084)2.11226980
63Insidious onset (HP:0003587)2.10789568
64Termporal pattern (HP:0011008)2.10789568
65Renal cortical cysts (HP:0000803)2.10758625
66Recurrent fungal infections (HP:0002841)2.10120849
67Adrenal hypoplasia (HP:0000835)2.09485795
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.09164051
69Chest pain (HP:0100749)2.08565153
70Papillary thyroid carcinoma (HP:0002895)2.08030927
71Chromsome breakage (HP:0040012)2.07404264
72Breast hypoplasia (HP:0003187)2.06047020
73Arterial tortuosity (HP:0005116)2.03756306
74Lipoatrophy (HP:0100578)1.99890842
75Abnormal pancreas size (HP:0012094)1.99648868
76Carpal bone hypoplasia (HP:0001498)1.98912404
77Patent foramen ovale (HP:0001655)1.98550957
78Aplasia/Hypoplasia of the thymus (HP:0010515)1.97423844
79Optic nerve coloboma (HP:0000588)1.97275125
80Periauricular skin pits (HP:0100277)1.96555110
81Preauricular pit (HP:0004467)1.96555110
82Abnormality of B cell number (HP:0010975)1.96464070
83Abnormality of the calcaneus (HP:0008364)1.93530267
84Meningitis (HP:0001287)1.93122808
85B lymphocytopenia (HP:0010976)1.92862505
86Neoplasm of the adrenal cortex (HP:0100641)1.91445719
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91185248
88Short 4th metacarpal (HP:0010044)1.91185248
89Meckel diverticulum (HP:0002245)1.89783669
90Arterial thrombosis (HP:0004420)1.89521104
91Aortic aneurysm (HP:0004942)1.89493052
92Petechiae (HP:0000967)1.89026802
93Hypoplastic left heart (HP:0004383)1.88520997
94Muscle hypertrophy of the lower extremities (HP:0008968)1.88351962
95Mesomelia (HP:0003027)1.88304965
96Eosinophilia (HP:0001880)1.87421201
97Poor head control (HP:0002421)1.86960707
98Impulsivity (HP:0100710)1.86960225
99Hepatoblastoma (HP:0002884)1.86800677
100Neoplasm of the adrenal gland (HP:0100631)1.86355361
101Keratoconjunctivitis sicca (HP:0001097)1.85711310
102Colitis (HP:0002583)1.84601578
103Prominent nose (HP:0000448)1.84298590
104Vascular tortuosity (HP:0004948)1.84101271
105Dysmetric saccades (HP:0000641)1.82330468
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81438591
107Short middle phalanx of the 5th finger (HP:0004220)1.81069497
108Rectal fistula (HP:0100590)1.80525664
109Rectovaginal fistula (HP:0000143)1.80525664
110Conjunctival telangiectasia (HP:0000524)1.80276835
111Gastrointestinal infarctions (HP:0005244)1.80189799
112Obstructive lung disease (HP:0006536)1.79294785
113Chronic obstructive pulmonary disease (HP:0006510)1.79294785
114Distal lower limb muscle weakness (HP:0009053)1.79111934
115Abnormality of macrophages (HP:0004311)1.78806706
116Abnormality of the common coagulation pathway (HP:0010990)1.78540681
117Intestinal fistula (HP:0100819)1.78193866
118Amaurosis fugax (HP:0100576)1.77488454
119Type 1 muscle fiber predominance (HP:0003803)1.77042665
120Sparse lateral eyebrow (HP:0005338)1.76761238
121Optic neuritis (HP:0100653)1.76002902
122Retrobulbar optic neuritis (HP:0100654)1.76002902
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.75634156
124Calcaneovalgus deformity (HP:0001848)1.75376265
125Abnormality of the incisor (HP:0000676)1.75241615
126IgA deficiency (HP:0002720)1.75019573
127Somatic mutation (HP:0001428)1.74966326
128Bilateral sensorineural hearing impairment (HP:0008619)1.74765633
129Abnormality of T cells (HP:0002843)1.74655357
130Hypoplastic heart (HP:0001961)1.74354279
131Subacute progressive viral hepatitis (HP:0006572)1.73649986
132Abnormality of the fingertips (HP:0001211)1.73571222
133Thyroid carcinoma (HP:0002890)1.73202174
134Deviation of the thumb (HP:0009603)1.73166281
135Abnormality of chromosome stability (HP:0003220)1.73052218
136Acute myeloid leukemia (HP:0004808)1.73042670
137Prolonged neonatal jaundice (HP:0006579)1.71449565
138Autoamputation (HP:0001218)1.71421761
139Abnormality of the intervertebral disk (HP:0005108)1.71382637
140Colon cancer (HP:0003003)1.71267387
141Vasculitis (HP:0002633)1.71116861
142Coarctation of aorta (HP:0001680)1.71116201
143Abnormality of the ileum (HP:0001549)1.70754734
144Increased variability in muscle fiber diameter (HP:0003557)1.70258934
145Glucose intolerance (HP:0000833)1.69973478
146Difficulty running (HP:0009046)1.69211278
147Reduced subcutaneous adipose tissue (HP:0003758)1.69079088
148Meningioma (HP:0002858)1.68878664
149Absent frontal sinuses (HP:0002688)1.68525700
150Cystic hygroma (HP:0000476)1.67549943
151Abnormality of the vasculature of the conjunctiva (HP:0008054)1.66722195
152Keratoconjunctivitis (HP:0001096)1.66636769
153Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66628027
154Recurrent cutaneous fungal infections (HP:0011370)1.63931470
155Chronic mucocutaneous candidiasis (HP:0002728)1.63931470
156Distal lower limb amyotrophy (HP:0008944)1.63525232
157Transitional cell carcinoma of the bladder (HP:0006740)1.62617066
158Nausea (HP:0002018)1.62347991
159Abnormal biliary tract morphology (HP:0012440)1.62202807
160Abnormality of the metopic suture (HP:0005556)1.61511966
161Sandal gap (HP:0001852)1.60907160
162Bladder neoplasm (HP:0009725)1.60737317
163Bladder carcinoma (HP:0002862)1.60737317
164Aplasia/Hypoplasia involving the musculature (HP:0001460)1.60402877
165Menstrual irregularities (HP:0000858)1.60018893
166Acute lymphatic leukemia (HP:0006721)1.59947668
167Thrombocytosis (HP:0001894)1.59110095
168Deformed tarsal bones (HP:0008119)1.58700038
169Abnormality of the thymus (HP:0000777)1.58104060
170Type 2 muscle fiber atrophy (HP:0003554)1.57348310
171Areflexia of lower limbs (HP:0002522)1.56951710
172Lymphoma (HP:0002665)1.56378383
173Respiratory difficulties (HP:0002880)1.54317168
174Abnormal ventriculo-arterial connection (HP:0011563)1.51926820
175Transposition of the great arteries (HP:0001669)1.51926820
176Abnormal connection of the cardiac segments (HP:0011545)1.51926820
177Prominent metopic ridge (HP:0005487)1.49465627
178Abnormal umbilical cord blood vessels (HP:0011403)1.48962331
179Single umbilical artery (HP:0001195)1.48962331
180Abnormality of the fetal cardiovascular system (HP:0010948)1.48962331
181Myelodysplasia (HP:0002863)1.48179637
182IgM deficiency (HP:0002850)1.46194850
183Myositis (HP:0100614)1.45065891
184Abnormality of the aortic arch (HP:0012303)1.43764309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.78250968
2ZAK3.59918746
3PRPF4B3.53032910
4OBSCN3.39498435
5MKNK13.25949723
6STK243.18940880
7EIF2AK13.12733053
8SRPK13.07508063
9PLK42.66860278
10STK38L2.66694981
11MKNK22.61233270
12SCYL22.55384396
13MAP3K102.35395224
14CDK122.19377860
15ERBB32.15891096
16BRSK22.03415098
17CDC71.98126925
18TRIB31.93172859
19EIF2AK21.92599449
20KSR21.83335174
21MAP3K21.78264598
22PLK31.78079598
23BUB11.73443823
24NEK91.72568713
25MAP3K131.69016001
26STK31.65429547
27NUAK11.64476899
28JAK11.60478666
29TRPM71.59316621
30CLK11.57476433
31IRAK41.47857301
32DMPK1.44886634
33SMG11.44442175
34MYLK1.44244677
35MAP2K31.43419426
36STK41.43359581
37EIF2AK31.40085509
38TXK1.34867807
39MAP3K141.32253562
40STK101.31332323
41WEE11.29325591
42WNK11.26853536
43KSR11.26424535
44BTK1.26230512
45JAK31.25005403
46FRK1.24391004
47MAP3K121.24331364
48PIK3CA1.23394441
49RPS6KA41.22928917
50BRD41.19546244
51EEF2K1.18652349
52CSK1.16497381
53IRAK31.15073382
54TTK1.14154199
55PBK1.12536539
56PLK11.11105301
57PIM11.10175878
58ACVR1B1.08118547
59BMPR21.06549669
60PLK21.05680003
61SYK1.05659410
62AKT31.05566801
63AURKB1.04439588
64TTN1.02801055
65CHUK1.02273165
66BRSK11.00781599
67PKN20.98408891
68JAK20.98303775
69ICK0.96565668
70HCK0.95529459
71YES10.94559330
72SGK20.94046672
73TESK10.92761802
74TGFBR10.91626432
75ATR0.88963656
76MAP3K10.88189545
77RAF10.88118696
78PDGFRB0.86478209
79MAPK120.85986203
80CDK80.85939295
81VRK10.84643835
82LIMK10.84068902
83PIM20.83830130
84HIPK20.82901286
85MELK0.82069425
86IKBKB0.79779610
87SIK30.79689190
88MARK30.78790987
89ALK0.77967605
90TYK20.76671345
91NEK60.76572193
92MAP3K30.75534564
93TEC0.75334127
94PASK0.75215498
95NEK10.75076343
96PDGFRA0.75037787
97PDK10.74565097
98FGFR30.72310553
99IKBKE0.72077631
100CHEK20.71899013
101FES0.69281023
102BLK0.66902219
103GRK60.65220649
104TAF10.64624155
105MAPK110.64194838
106RET0.63944559
107MAP3K90.63513478
108NEK20.61352656
109ATM0.60218450
110CSF1R0.59479175
111TGFBR20.58561544
112CSNK2A10.58107077
113NLK0.57601390
114AURKA0.57064697
115MARK20.56229072
116LATS10.54878509
117MST40.53621027
118CHEK10.53610282
119EPHA20.53510022
120PDPK10.53301039
121MAP4K10.51857122
122NME20.51808103
123MTOR0.51256345
124SGK30.49988498
125RPS6KA60.48767303
126LCK0.48398760
127MAP3K60.48201393
128RPS6KC10.47534609
129RPS6KL10.47534609
130CDK40.47234625
131ITK0.46302435
132CAMKK20.44612885
133CDK60.44366465
134MAPKAPK20.44293475
135BMX0.43575401
136CDK70.42614369
137MAP3K70.41518566
138CCNB10.40586960
139BRAF0.40503049
140MAP2K10.40437627
141PIK3CG0.40202148
142PAK20.39666666
143SIK10.39541923
144RPS6KB20.39363968
145TSSK60.38482243
146MAP3K80.38478372
147RPS6KB10.37623901
148ILK0.36975776
149MOS0.36228469
150CDK20.35903212
151LRRK20.34180528
152RPS6KA50.34067694
153ZAP700.33924652
154MAP3K50.33893424
155MAPK100.33751154
156TLK10.33124457

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.28272710
2Mismatch repair_Homo sapiens_hsa034303.23727122
3Proteasome_Homo sapiens_hsa030503.16247538
4Cell cycle_Homo sapiens_hsa041102.59893241
5Homologous recombination_Homo sapiens_hsa034402.54676521
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54191421
7Base excision repair_Homo sapiens_hsa034102.51628784
8B cell receptor signaling pathway_Homo sapiens_hsa046622.36071484
9RNA polymerase_Homo sapiens_hsa030202.35293736
10Non-small cell lung cancer_Homo sapiens_hsa052232.32981919
11Non-homologous end-joining_Homo sapiens_hsa034502.32587877
12RNA transport_Homo sapiens_hsa030132.29531167
13Spliceosome_Homo sapiens_hsa030402.21304013
14Nucleotide excision repair_Homo sapiens_hsa034202.15438842
15Basal transcription factors_Homo sapiens_hsa030221.96912264
16RNA degradation_Homo sapiens_hsa030181.94955112
17Renal cell carcinoma_Homo sapiens_hsa052111.93459337
18Acute myeloid leukemia_Homo sapiens_hsa052211.86731407
19One carbon pool by folate_Homo sapiens_hsa006701.75898480
20Fanconi anemia pathway_Homo sapiens_hsa034601.75157617
21Platelet activation_Homo sapiens_hsa046111.73596557
22Pyrimidine metabolism_Homo sapiens_hsa002401.64769880
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62427661
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55222307
25Glioma_Homo sapiens_hsa052141.51952991
26mRNA surveillance pathway_Homo sapiens_hsa030151.51146152
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51044736
28Osteoclast differentiation_Homo sapiens_hsa043801.49449174
29p53 signaling pathway_Homo sapiens_hsa041151.48387832
30Epstein-Barr virus infection_Homo sapiens_hsa051691.40450743
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40278020
32Herpes simplex infection_Homo sapiens_hsa051681.36736673
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32334465
34VEGF signaling pathway_Homo sapiens_hsa043701.31765514
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31491344
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28735957
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.27784202
38Measles_Homo sapiens_hsa051621.21702834
39Viral myocarditis_Homo sapiens_hsa054161.21695446
40Antigen processing and presentation_Homo sapiens_hsa046121.20578226
41ErbB signaling pathway_Homo sapiens_hsa040121.20530054
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19943861
43Primary immunodeficiency_Homo sapiens_hsa053401.19122716
44Ribosome_Homo sapiens_hsa030101.18902731
45Adherens junction_Homo sapiens_hsa045201.14383816
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.14344681
47Long-term potentiation_Homo sapiens_hsa047201.13978827
48Dorso-ventral axis formation_Homo sapiens_hsa043201.13434455
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11171213
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.09139183
51Chemokine signaling pathway_Homo sapiens_hsa040621.08508952
52Tuberculosis_Homo sapiens_hsa051521.08498553
53Legionellosis_Homo sapiens_hsa051341.08005199
54TGF-beta signaling pathway_Homo sapiens_hsa043501.06881759
55Prolactin signaling pathway_Homo sapiens_hsa049171.04695847
56mTOR signaling pathway_Homo sapiens_hsa041501.04077576
57Leishmaniasis_Homo sapiens_hsa051401.02598333
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01662236
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01018169
60Protein export_Homo sapiens_hsa030600.98991909
61Purine metabolism_Homo sapiens_hsa002300.98900258
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98758328
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.98137492
64HTLV-I infection_Homo sapiens_hsa051660.98027490
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.97297027
66Thyroid cancer_Homo sapiens_hsa052160.95561460
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95544556
68Inositol phosphate metabolism_Homo sapiens_hsa005620.94973221
69MicroRNAs in cancer_Homo sapiens_hsa052060.93961742
70Allograft rejection_Homo sapiens_hsa053300.93210777
71Choline metabolism in cancer_Homo sapiens_hsa052310.93105255
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89383496
73Small cell lung cancer_Homo sapiens_hsa052220.87689043
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86724329
75TNF signaling pathway_Homo sapiens_hsa046680.86352963
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86311897
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86222113
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85970618
79Viral carcinogenesis_Homo sapiens_hsa052030.85181755
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.83446135
81Influenza A_Homo sapiens_hsa051640.81221468
82Graft-versus-host disease_Homo sapiens_hsa053320.81188757
83Hepatitis C_Homo sapiens_hsa051600.80867771
84Hippo signaling pathway_Homo sapiens_hsa043900.79970157
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79623975
86Insulin signaling pathway_Homo sapiens_hsa049100.78503872
87Estrogen signaling pathway_Homo sapiens_hsa049150.78307335
88Arachidonic acid metabolism_Homo sapiens_hsa005900.77702185
89Apoptosis_Homo sapiens_hsa042100.76129293
90Shigellosis_Homo sapiens_hsa051310.75071505
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.73712803
92Bladder cancer_Homo sapiens_hsa052190.72527927
93GnRH signaling pathway_Homo sapiens_hsa049120.71705615
94Type I diabetes mellitus_Homo sapiens_hsa049400.71523293
95Autoimmune thyroid disease_Homo sapiens_hsa053200.71497574
96Hematopoietic cell lineage_Homo sapiens_hsa046400.70919206
97Endocytosis_Homo sapiens_hsa041440.70305860
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70233724
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69596764
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68996547
101Melanoma_Homo sapiens_hsa052180.68448036
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68080539
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67570629
104Prostate cancer_Homo sapiens_hsa052150.67176539
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66377851
106Hepatitis B_Homo sapiens_hsa051610.66104160
107Toxoplasmosis_Homo sapiens_hsa051450.65759622
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64881758
109Staphylococcus aureus infection_Homo sapiens_hsa051500.64340868
110Insulin resistance_Homo sapiens_hsa049310.64324891
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61887445
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.60905808
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60426327
114Amoebiasis_Homo sapiens_hsa051460.59400786
115Asthma_Homo sapiens_hsa053100.59308469
116HIF-1 signaling pathway_Homo sapiens_hsa040660.58972005
117Galactose metabolism_Homo sapiens_hsa000520.58662312
118Dilated cardiomyopathy_Homo sapiens_hsa054140.58267074
119Huntingtons disease_Homo sapiens_hsa050160.56733873
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56249610
121Malaria_Homo sapiens_hsa051440.56032088
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55972304
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55562115
124Oocyte meiosis_Homo sapiens_hsa041140.55448843
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55339776
126MAPK signaling pathway_Homo sapiens_hsa040100.54600108
127Glutathione metabolism_Homo sapiens_hsa004800.53728438
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52182819
129Tight junction_Homo sapiens_hsa045300.52116727
130FoxO signaling pathway_Homo sapiens_hsa040680.52076385
131Circadian rhythm_Homo sapiens_hsa047100.50898739
132Focal adhesion_Homo sapiens_hsa045100.50395186
133Ras signaling pathway_Homo sapiens_hsa040140.49656610
134Systemic lupus erythematosus_Homo sapiens_hsa053220.49570483
135Chronic myeloid leukemia_Homo sapiens_hsa052200.49142547
136Endometrial cancer_Homo sapiens_hsa052130.48423265
137Pancreatic cancer_Homo sapiens_hsa052120.46736437
138T cell receptor signaling pathway_Homo sapiens_hsa046600.45366718
139Basal cell carcinoma_Homo sapiens_hsa052170.44968231
140Pathways in cancer_Homo sapiens_hsa052000.42559494
141Colorectal cancer_Homo sapiens_hsa052100.42359654
142Proteoglycans in cancer_Homo sapiens_hsa052050.40598082
143Notch signaling pathway_Homo sapiens_hsa043300.39969618
144Parkinsons disease_Homo sapiens_hsa050120.39670817
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39222546
146Pertussis_Homo sapiens_hsa051330.38177343
147Salmonella infection_Homo sapiens_hsa051320.37379241
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36575236
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35371938
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.35318512

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