PTP4A2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.91271034
2protein neddylation (GO:0045116)8.27303283
3neutrophil activation involved in immune response (GO:0002283)7.21190336
4blood coagulation, intrinsic pathway (GO:0007597)6.47441634
5regulation of platelet aggregation (GO:0090330)6.02954398
6regulation of platelet activation (GO:0010543)5.72200568
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66449223
8negative regulation of heart rate (GO:0010459)5.63220870
9negative regulation of thymocyte apoptotic process (GO:0070244)5.60898042
10adenosine receptor signaling pathway (GO:0001973)5.44368475
11leukocyte migration involved in inflammatory response (GO:0002523)5.41026161
12platelet aggregation (GO:0070527)5.31987963
13positive regulation of endothelial cell differentiation (GO:0045603)5.18180315
14regulation of integrin-mediated signaling pathway (GO:2001044)5.15968232
15negative regulation of norepinephrine secretion (GO:0010700)5.14180357
16negative regulation of platelet activation (GO:0010544)4.99557121
17negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.96212853
18negative regulation of homotypic cell-cell adhesion (GO:0034111)4.92532206
19positive regulation of mast cell activation (GO:0033005)4.85631425
20angiogenesis involved in wound healing (GO:0060055)4.75038721
21low-density lipoprotein particle remodeling (GO:0034374)4.39006034
22lipoxygenase pathway (GO:0019372)4.32269100
23purinergic nucleotide receptor signaling pathway (GO:0035590)4.31669900
24neutrophil activation (GO:0042119)4.30913654
25regulation of lipoprotein metabolic process (GO:0050746)4.30247865
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.28318066
27negative regulation of response to food (GO:0032096)4.24040344
28negative regulation of appetite (GO:0032099)4.24040344
29positive regulation of cAMP-mediated signaling (GO:0043950)4.20339167
30negative regulation of protein localization to cell surface (GO:2000009)4.03834416
31fusion of sperm to egg plasma membrane (GO:0007342)3.96066472
32platelet degranulation (GO:0002576)3.94495957
33regulation of Golgi to plasma membrane protein transport (GO:0042996)3.94103331
34positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.88899528
35polyamine biosynthetic process (GO:0006596)3.87114640
36positive regulation of systemic arterial blood pressure (GO:0003084)3.86163273
37negative regulation of heart contraction (GO:0045822)3.80284631
38regulation of endothelial cell differentiation (GO:0045601)3.78975270
39platelet activation (GO:0030168)3.78730034
40positive regulation of Rho protein signal transduction (GO:0035025)3.77706178
41negative regulation of T cell apoptotic process (GO:0070233)3.77055326
42granulocyte activation (GO:0036230)3.72162693
43regulation of integrin activation (GO:0033623)3.70437523
44homotypic cell-cell adhesion (GO:0034109)3.67831619
45purinergic receptor signaling pathway (GO:0035587)3.63465760
46regulation of norepinephrine secretion (GO:0014061)3.63347311
47regulation of homotypic cell-cell adhesion (GO:0034110)3.61061669
48regulation of macrophage derived foam cell differentiation (GO:0010743)3.58041333
49beta-amyloid metabolic process (GO:0050435)3.56811917
50platelet dense granule organization (GO:0060155)3.52502121
51negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.42184683
52termination of G-protein coupled receptor signaling pathway (GO:0038032)3.41879967
53positive regulation of macrophage differentiation (GO:0045651)3.39060080
54mitochondrial calcium ion transport (GO:0006851)3.38934728
55positive regulation of receptor recycling (GO:0001921)3.38310824
56regulation of MHC class II biosynthetic process (GO:0045346)3.36937161
57negative regulation of calcium ion transport into cytosol (GO:0010523)3.35169560
58platelet formation (GO:0030220)3.33836397
59autophagic vacuole fusion (GO:0000046)3.33215478
60megakaryocyte development (GO:0035855)3.32021994
61negative regulation of catecholamine secretion (GO:0033604)3.30772204
62phospholipid homeostasis (GO:0055091)3.30520497
63termination of signal transduction (GO:0023021)3.30225381
64regulation of female receptivity (GO:0045924)3.29449712
65long-chain fatty acid biosynthetic process (GO:0042759)3.28188327
66G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.27268795
67endothelium development (GO:0003158)3.22554070
68positive regulation of hemostasis (GO:1900048)3.19789181
69positive regulation of blood coagulation (GO:0030194)3.19789181
70negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.19360816
71regulation of cholesterol efflux (GO:0010874)3.13484019
72negative regulation of neural precursor cell proliferation (GO:2000178)3.13177086
73high-density lipoprotein particle remodeling (GO:0034375)3.10580489
74pyrimidine nucleoside catabolic process (GO:0046135)3.09921417
75extracellular fibril organization (GO:0043206)3.07239545
76plasma membrane fusion (GO:0045026)3.02196378
77phagocytosis, engulfment (GO:0006911)2.99307350
78cellular biogenic amine biosynthetic process (GO:0042401)2.97908663
79reverse cholesterol transport (GO:0043691)2.97338149
80regulation of sensory perception (GO:0051931)2.97234069
81regulation of sensory perception of pain (GO:0051930)2.97234069
82negative regulation of blood circulation (GO:1903523)2.95706846
83vesicle targeting (GO:0006903)2.93142014
84microtubule depolymerization (GO:0007019)2.91740683
85mesodermal cell differentiation (GO:0048333)2.90473364
86positive regulation of coagulation (GO:0050820)2.89357519
87positive regulation of mast cell degranulation (GO:0043306)2.89329835
88positive regulation of mast cell activation involved in immune response (GO:0033008)2.89329835
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.89190244
90leukocyte degranulation (GO:0043299)2.88172694
91regulation of mast cell activation (GO:0033003)2.87713145
92positive regulation of granulocyte differentiation (GO:0030854)2.87085446
93relaxation of smooth muscle (GO:0044557)2.86808527
94female mating behavior (GO:0060180)2.85293050
95regulation of blood coagulation (GO:0030193)2.83660068
96regulation of hemostasis (GO:1900046)2.83660068
97amine biosynthetic process (GO:0009309)2.81268417
98regulation of thymocyte apoptotic process (GO:0070243)2.80232357
99regulation of memory T cell differentiation (GO:0043380)2.77232048
100monoamine transport (GO:0015844)2.75521457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.68894894
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.18311747
3SCL_19346495_ChIP-Seq_HPC-7_Human3.81997940
4EZH2_22144423_ChIP-Seq_EOC_Human3.68257426
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.45258557
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.94145646
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.92680976
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75292472
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72570328
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.59769248
11GATA1_19941826_ChIP-Seq_K562_Human2.54085089
12GBX2_23144817_ChIP-Seq_PC3_Human2.31380640
13GATA2_19941826_ChIP-Seq_K562_Human2.25573831
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.22565685
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.15972009
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.13652762
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10974250
18GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.05442983
19GATA2_21666600_ChIP-Seq_HMVEC_Human2.02338378
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02225482
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.98628368
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97458797
23TAF15_26573619_Chip-Seq_HEK293_Human1.94702997
24HTT_18923047_ChIP-ChIP_STHdh_Human1.93549937
25SPI1_23127762_ChIP-Seq_K562_Human1.93222120
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80977164
27GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77382391
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76106518
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72675960
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70400656
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68895228
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62842407
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53981487
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.49439002
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45379819
36GATA1_19941827_ChIP-Seq_MEL86_Mouse1.44332003
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43694866
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43401040
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.42376461
40VDR_22108803_ChIP-Seq_LS180_Human1.42095514
41GATA1_22025678_ChIP-Seq_K562_Human1.39548651
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33059383
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.28679868
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22896783
45EWS_26573619_Chip-Seq_HEK293_Human1.22433690
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21817413
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21817413
48KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18502652
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17990784
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17977002
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17761014
52IRF1_19129219_ChIP-ChIP_H3396_Human1.16908977
53RUNX_20019798_ChIP-Seq_JUKART_Human1.15752544
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.14762580
55SALL4_22934838_ChIP-ChIP_CD34+_Human1.14022800
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13513827
57BCAT_22108803_ChIP-Seq_LS180_Human1.12694150
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11464152
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.11108710
60SPI1_20517297_ChIP-Seq_HL60_Human1.08968924
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04918045
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04650763
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04252486
64AR_25329375_ChIP-Seq_VCAP_Human1.03360401
65SMAD4_21799915_ChIP-Seq_A2780_Human1.01664929
66NANOG_19829295_ChIP-Seq_ESCs_Human1.01543121
67SOX2_19829295_ChIP-Seq_ESCs_Human1.01543121
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01470495
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01361851
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99977439
71ER_23166858_ChIP-Seq_MCF-7_Human0.98747266
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.97747414
73SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94671935
74LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92331259
75P53_22387025_ChIP-Seq_ESCs_Mouse0.91754367
76PIAS1_25552417_ChIP-Seq_VCAP_Human0.90918190
77P300_19829295_ChIP-Seq_ESCs_Human0.90436891
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89876733
79OCT1_27270436_Chip-Seq_PROSTATE_Human0.88495936
80AR_20517297_ChIP-Seq_VCAP_Human0.87437303
81GATA3_26560356_Chip-Seq_TH2_Human0.87064698
82NANOG_20526341_ChIP-Seq_ESCs_Human0.86810019
83TCF4_18268006_ChIP-ChIP_LS174T_Human0.85908116
84ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85781959
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82285624
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.81517045
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81501628
88ERG_20517297_ChIP-Seq_VCAP_Human0.81332889
89RNF2_27304074_Chip-Seq_NSC_Mouse0.81163466
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80353276
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79493939
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78968466
93SMRT_27268052_Chip-Seq_Bcells_Human0.78495239
94GATA3_27048872_Chip-Seq_THYMUS_Human0.78432035
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.77827324
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77243575
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76696757
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.76628568
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75458978
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75180976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.21353469
2MP0003724_increased_susceptibility_to3.48765261
3MP0000465_gastrointestinal_hemorrhage3.45874165
4MP0004510_myositis3.00482168
5MP0005083_abnormal_biliary_tract2.76264193
6MP0004084_abnormal_cardiac_muscle2.54416866
7MP0002736_abnormal_nociception_after2.52037959
8MP0000230_abnormal_systemic_arterial2.44137057
9MP0000343_altered_response_to2.20080632
10MP0001879_abnormal_lymphatic_vessel2.20033420
11MP0008775_abnormal_heart_ventricle2.11757642
12MP0005084_abnormal_gallbladder_morpholo2.05653457
13MP0005464_abnormal_platelet_physiology10.1628349
14MP0001835_abnormal_antigen_presentation1.95376384
15MP0003566_abnormal_cell_adhesion1.94267537
16MP0005167_abnormal_blood-brain_barrier1.78379403
17MP0003638_abnormal_response/metabolism_1.77603297
18MP0008872_abnormal_physiological_respon1.76184416
19MP0003303_peritoneal_inflammation1.75446767
20MP0004036_abnormal_muscle_relaxation1.69138144
21MP0005671_abnormal_response_to1.67705966
22MP0005410_abnormal_fertilization1.64577395
23MP0004130_abnormal_muscle_cell1.64530038
24MP0003828_pulmonary_edema1.63564607
25MP0001968_abnormal_touch/_nociception1.61897809
26MP0003879_abnormal_hair_cell1.59762195
27MP0002148_abnormal_hypersensitivity_rea1.48249936
28MP0005646_abnormal_pituitary_gland1.45977891
29MP0010155_abnormal_intestine_physiology1.37723876
30MP0002733_abnormal_thermal_nociception1.36555712
31MP0005058_abnormal_lysosome_morphology1.35580379
32MP0006276_abnormal_autonomic_nervous1.33673105
33MP0005000_abnormal_immune_tolerance1.33051319
34MP0000249_abnormal_blood_vessel1.32636326
35MP0001851_eye_inflammation1.27543813
36MP0002398_abnormal_bone_marrow1.27380994
37MP0004215_abnormal_myocardial_fiber1.26152971
38MP0001663_abnormal_digestive_system1.24801709
39MP0009697_abnormal_copulation1.23171889
40MP0005174_abnormal_tail_pigmentation1.20145473
41MP0010329_abnormal_lipoprotein_level1.19959993
42MP0003136_yellow_coat_color1.13450847
43MP0009763_increased_sensitivity_to1.13113730
44MP0009764_decreased_sensitivity_to1.11672477
45MP0000015_abnormal_ear_pigmentation1.10903315
46MP0004484_altered_response_of1.10082320
47MP0002132_abnormal_respiratory_system1.08633369
48MP0004947_skin_inflammation1.07714963
49MP0002723_abnormal_immune_serum1.04695761
50MP0001970_abnormal_pain_threshold1.04583624
51MP0000383_abnormal_hair_follicle1.03614039
52MP0003866_abnormal_defecation1.01910301
53MP0002102_abnormal_ear_morphology1.01579225
54MP0001800_abnormal_humoral_immune0.99939182
55MP0003011_delayed_dark_adaptation0.96749347
56MP0010368_abnormal_lymphatic_system0.94481123
57MP0005248_abnormal_Harderian_gland0.94345225
58MP0002972_abnormal_cardiac_muscle0.92677872
59MP0002452_abnormal_antigen_presenting0.92200292
60MP0000689_abnormal_spleen_morphology0.91996415
61MP0009642_abnormal_blood_homeostasis0.90922167
62MP0005165_increased_susceptibility_to0.90199072
63MP0001533_abnormal_skeleton_physiology0.89341029
64MP0006054_spinal_hemorrhage0.87663055
65MP0002429_abnormal_blood_cell0.87527884
66MP0001544_abnormal_cardiovascular_syste0.86621070
67MP0005385_cardiovascular_system_phenoty0.86621070
68MP0006138_congestive_heart_failure0.86098270
69MP0008874_decreased_physiological_sensi0.83616307
70MP0009765_abnormal_xenobiotic_induced0.81912444
71MP0005620_abnormal_muscle_contractility0.81554342
72MP0002420_abnormal_adaptive_immunity0.81115991
73MP0003436_decreased_susceptibility_to0.80972138
74MP0009780_abnormal_chondrocyte_physiolo0.80198987
75MP0005381_digestive/alimentary_phenotyp0.79580583
76MP0001819_abnormal_immune_cell0.79487183
77MP0004134_abnormal_chest_morphology0.77111238
78MP0005387_immune_system_phenotype0.76991219
79MP0001790_abnormal_immune_system0.76991219
80MP0000858_altered_metastatic_potential0.76805555
81MP0001756_abnormal_urination0.76682076
82MP0001845_abnormal_inflammatory_respons0.76395730
83MP0002722_abnormal_immune_system0.76357381
84MP0001545_abnormal_hematopoietic_system0.75679144
85MP0005397_hematopoietic_system_phenotyp0.75679144
86MP0006036_abnormal_mitochondrial_physio0.74851016
87MP0003656_abnormal_erythrocyte_physiolo0.74727268
88MP0001765_abnormal_ion_homeostasis0.74335174
89MP0004085_abnormal_heartbeat0.73841438
90MP0000716_abnormal_immune_system0.73318602
91MP0001664_abnormal_digestion0.73034139
92MP0004142_abnormal_muscle_tone0.72007119
93MP0002653_abnormal_ependyma_morphology0.71168536
94MP0005535_abnormal_body_temperature0.70959346
95MP0000685_abnormal_immune_system0.68124421
96MP0006035_abnormal_mitochondrial_morpho0.66543993
97MP0002128_abnormal_blood_circulation0.65740489
98MP0002419_abnormal_innate_immunity0.64466343
99MP0004883_abnormal_blood_vessel0.61270772
100MP0009333_abnormal_splenocyte_physiolog0.59617465

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.97874487
2Purpura (HP:0000979)9.46953226
3Epistaxis (HP:0000421)7.67353826
4Gingival bleeding (HP:0000225)6.57172816
5Hyperlipoproteinemia (HP:0010980)6.19946717
6Abnormal platelet function (HP:0011869)5.56630908
7Impaired platelet aggregation (HP:0003540)5.56630908
8Poikilocytosis (HP:0004447)4.20672786
9Dyschromatopsia (HP:0007641)4.05909669
10Spontaneous hematomas (HP:0007420)4.05159498
11Acanthocytosis (HP:0001927)3.92048154
12Conjunctival telangiectasia (HP:0000524)3.59919701
13Bruising susceptibility (HP:0000978)3.26239075
14Abnormality of lateral ventricle (HP:0030047)3.24905580
15Abnormal pupillary function (HP:0007686)3.20503678
16Abnormality of the common coagulation pathway (HP:0010990)3.19125268
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.08592229
18Increased density of long bones (HP:0006392)2.94089631
19Paralysis (HP:0003470)2.92089447
20Abnormality of the heme biosynthetic pathway (HP:0010472)2.77932461
21Xanthomatosis (HP:0000991)2.60922800
22Decreased central vision (HP:0007663)2.60751678
23Stomatitis (HP:0010280)2.58890994
24Increased IgM level (HP:0003496)2.46637843
25Abnormal auditory evoked potentials (HP:0006958)2.46003069
263-Methylglutaconic aciduria (HP:0003535)2.31742355
27Upper limb muscle weakness (HP:0003484)2.28553303
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27978118
29Hepatosplenomegaly (HP:0001433)2.21432669
30Joint swelling (HP:0001386)2.21380070
31Joint hemorrhage (HP:0005261)2.15379129
32Hyperthyroidism (HP:0000836)2.08975210
33Tinnitus (HP:0000360)2.08131085
34Thyroid-stimulating hormone excess (HP:0002925)2.02221081
35Nausea (HP:0002018)2.00670481
36Prolonged bleeding time (HP:0003010)12.0411271
37Menorrhagia (HP:0000132)11.3586067
38Increased mean platelet volume (HP:0011877)11.1491311
39Abnormal platelet volume (HP:0011876)10.4499066
40Papillary thyroid carcinoma (HP:0002895)1.98322476
41Abnormality of macrophages (HP:0004311)1.97772315
42Abnormality of alanine metabolism (HP:0010916)1.95329987
43Hyperalaninemia (HP:0003348)1.95329987
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95329987
45Ventricular fibrillation (HP:0001663)1.94961420
46Abnormal ciliary motility (HP:0012262)1.91771579
47Abnormality of iron homeostasis (HP:0011031)1.91401049
48Spontaneous abortion (HP:0005268)1.86907301
49Encephalitis (HP:0002383)1.86562793
50Male infertility (HP:0003251)1.84331225
51Episodic fever (HP:0001954)1.83118621
52Abnormal respiratory motile cilium morphology (HP:0005938)1.81160407
53Abnormal respiratory epithelium morphology (HP:0012253)1.81160407
54Generalized aminoaciduria (HP:0002909)1.77881513
55Autoimmune hemolytic anemia (HP:0001890)1.74827052
56Abnormality of transition element cation homeostasis (HP:0011030)1.70015009
57Tongue fasciculations (HP:0001308)1.67162348
58Hypophosphatemic rickets (HP:0004912)1.65073399
59Basal ganglia calcification (HP:0002135)1.63690445
60Distal lower limb amyotrophy (HP:0008944)1.61948242
61Dysautonomia (HP:0002459)1.61683040
62Exertional dyspnea (HP:0002875)1.61011304
63Arterial thrombosis (HP:0004420)1.58636270
64Polyphagia (HP:0002591)1.58127584
65Uterine leiomyosarcoma (HP:0002891)1.56757577
66Leiomyosarcoma (HP:0100243)1.56757577
67Transitional cell carcinoma of the bladder (HP:0006740)1.56066186
68Muscle fibrillation (HP:0010546)1.55542634
69Polycythemia (HP:0001901)1.53490304
70Infertility (HP:0000789)1.53445804
71Arthropathy (HP:0003040)1.52821439
72Abnormality of binocular vision (HP:0011514)1.52671561
73Diplopia (HP:0000651)1.52671561
74Obstructive lung disease (HP:0006536)1.50368704
75Chronic obstructive pulmonary disease (HP:0006510)1.50368704
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.49124948
77Increased serum ferritin (HP:0003281)1.48059908
78Back pain (HP:0003418)1.47480469
79Congenital sensorineural hearing impairment (HP:0008527)1.46053961
80Renal Fanconi syndrome (HP:0001994)1.45339395
81Vertigo (HP:0002321)1.42553255
82Abnormal respiratory motile cilium physiology (HP:0012261)1.42299458
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.40777451
84Absent/shortened dynein arms (HP:0200106)1.40777451
85Bladder carcinoma (HP:0002862)1.40738997
86Bladder neoplasm (HP:0009725)1.40738997
87Testicular neoplasm (HP:0010788)1.39534695
88Thyroid carcinoma (HP:0002890)1.36890273
89Biliary tract neoplasm (HP:0100574)1.35250093
90Intellectual disability, profound (HP:0002187)1.34668312
91Myocardial infarction (HP:0001658)1.33682399
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.33016438
93Abnormality of the prostate (HP:0008775)1.32954846
94Central scotoma (HP:0000603)1.24748141
95Lower limb amyotrophy (HP:0007210)1.24449173
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.23895197
97Eosinophilia (HP:0001880)1.22562513
98Leukocytosis (HP:0001974)1.22155550
99Abnormality of the renal cortex (HP:0011035)1.22002957
100Thrombocytosis (HP:0001894)1.21546625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.15674391
2RIPK44.77867715
3BMX4.23842385
4MYLK3.61420143
5EIF2AK13.06548446
6TEC2.94924838
7BTK2.73774332
8PTK2B2.67314736
9GRK52.17022825
10PIK3CG2.15941618
11SYK2.10534381
12ADRBK22.05269104
13PNCK1.94015132
14TAOK31.92951145
15BMPR21.89077053
16ILK1.87595954
17CSF1R1.84579877
18ZAP701.70990629
19GRK61.69426373
20ACVR1B1.61971457
21STK31.58818910
22TNIK1.53351778
23FGR1.37373237
24CAMKK21.32233021
25TLK11.30602383
26HCK1.28452313
27PLK21.26227067
28STK241.23925625
29MAPKAPK31.19641762
30TNK21.17415832
31DAPK31.11608077
32PIM21.10269964
33BMPR1B1.06821043
34FES1.06622963
35PAK11.03486760
36SIK31.03182898
37TXK1.01089628
38ADRBK10.99941601
39IKBKB0.99783372
40LYN0.97141952
41MATK0.97008634
42DAPK20.89039069
43BLK0.87992029
44MAP3K120.85871421
45NUAK10.85756869
46ITK0.84981903
47LMTK20.83422919
48MAP4K20.81421319
49TRIM280.81247452
50MINK10.80793477
51ERBB20.79594070
52GRK10.78459338
53MAPK130.76436025
54MAP3K50.76172594
55CSK0.72724177
56EPHB20.68523403
57PAK30.66304091
58IRAK10.65963110
59PRKD10.63394215
60MARK30.63370639
61PDGFRB0.62655795
62STK160.59697191
63PKN10.58799864
64PDK10.57392929
65EPHA30.55068773
66TESK20.54998540
67PRKACG0.52637382
68RET0.50895525
69DYRK20.48121613
70ROCK10.46787557
71DAPK10.46704051
72DYRK1B0.45309249
73TYRO30.45102729
74MAP2K30.44553035
75TAOK20.43737331
76PRKG10.43322109
77PRKCQ0.41268646
78PINK10.40137897
79ZAK0.40101464
80LCK0.39710281
81TAOK10.39360709
82STK40.39227195
83PDPK10.39087838
84MAP3K110.38916680
85FER0.38216367
86FYN0.37556940
87JAK20.36516587
88DYRK30.35720533
89BRSK20.35514900
90MAPK120.35212882
91MAP2K10.33455844
92FRK0.33416493
93IGF1R0.30677747
94KDR0.30567118
95PRKCD0.30481092
96PRKCB0.29775209
97PRKCA0.29530049
98DYRK1A0.28513684
99YES10.26650488
100SRC0.26225419

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.82609748
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.73715736
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.93366869
4Hematopoietic cell lineage_Homo sapiens_hsa046402.58260705
5ECM-receptor interaction_Homo sapiens_hsa045122.51140348
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.40010159
7Arachidonic acid metabolism_Homo sapiens_hsa005902.33144218
8Nitrogen metabolism_Homo sapiens_hsa009102.29606229
9Vascular smooth muscle contraction_Homo sapiens_hsa042702.00082051
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94269100
11Gap junction_Homo sapiens_hsa045401.90801522
12Serotonergic synapse_Homo sapiens_hsa047261.84964765
13Chemokine signaling pathway_Homo sapiens_hsa040621.83533719
14Collecting duct acid secretion_Homo sapiens_hsa049661.81595592
15Linoleic acid metabolism_Homo sapiens_hsa005911.57457997
16Alcoholism_Homo sapiens_hsa050341.48912269
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41662412
18Glycerolipid metabolism_Homo sapiens_hsa005611.39590126
19Pancreatic secretion_Homo sapiens_hsa049721.37060306
20Systemic lupus erythematosus_Homo sapiens_hsa053221.30465406
21Sulfur metabolism_Homo sapiens_hsa009201.29320945
22Endocytosis_Homo sapiens_hsa041441.27430984
23Olfactory transduction_Homo sapiens_hsa047401.25860996
24Long-term depression_Homo sapiens_hsa047301.16377352
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14239955
26Circadian entrainment_Homo sapiens_hsa047131.13196575
27Primary immunodeficiency_Homo sapiens_hsa053401.13079389
28Shigellosis_Homo sapiens_hsa051311.10272500
29Morphine addiction_Homo sapiens_hsa050321.07433246
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07417770
31T cell receptor signaling pathway_Homo sapiens_hsa046601.07219685
32Fatty acid elongation_Homo sapiens_hsa000621.06591983
33Phospholipase D signaling pathway_Homo sapiens_hsa040720.99777690
34B cell receptor signaling pathway_Homo sapiens_hsa046620.98687890
35Leukocyte transendothelial migration_Homo sapiens_hsa046700.98442493
36Rap1 signaling pathway_Homo sapiens_hsa040150.96177962
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92112808
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89929997
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89160628
40Phagosome_Homo sapiens_hsa041450.87631124
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84054874
42Fat digestion and absorption_Homo sapiens_hsa049750.83379739
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82445630
44Calcium signaling pathway_Homo sapiens_hsa040200.81163231
45Phototransduction_Homo sapiens_hsa047440.80660108
46Glutathione metabolism_Homo sapiens_hsa004800.80181555
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78595198
48Malaria_Homo sapiens_hsa051440.75835125
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75709314
50Focal adhesion_Homo sapiens_hsa045100.75076782
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71529484
52Steroid biosynthesis_Homo sapiens_hsa001000.71267161
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.70658939
54GABAergic synapse_Homo sapiens_hsa047270.69655297
55Ras signaling pathway_Homo sapiens_hsa040140.69331956
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67912577
57Dilated cardiomyopathy_Homo sapiens_hsa054140.67317035
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67275920
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65683443
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.62976167
61Choline metabolism in cancer_Homo sapiens_hsa052310.62710380
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62705059
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60328477
64Cholinergic synapse_Homo sapiens_hsa047250.58789959
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58533636
66beta-Alanine metabolism_Homo sapiens_hsa004100.56727279
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54275329
68Osteoclast differentiation_Homo sapiens_hsa043800.54070171
69Renin secretion_Homo sapiens_hsa049240.53756596
70Non-small cell lung cancer_Homo sapiens_hsa052230.53346829
71Synaptic vesicle cycle_Homo sapiens_hsa047210.50830254
72Gastric acid secretion_Homo sapiens_hsa049710.49745632
73Small cell lung cancer_Homo sapiens_hsa052220.49177131
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48929593
75Chemical carcinogenesis_Homo sapiens_hsa052040.48147460
76Mismatch repair_Homo sapiens_hsa034300.47643982
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46248165
78Oxytocin signaling pathway_Homo sapiens_hsa049210.45896288
79Glutamatergic synapse_Homo sapiens_hsa047240.45732627
80Salivary secretion_Homo sapiens_hsa049700.45210634
81Starch and sucrose metabolism_Homo sapiens_hsa005000.45175222
82Viral carcinogenesis_Homo sapiens_hsa052030.44461169
83Renin-angiotensin system_Homo sapiens_hsa046140.43296300
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42858825
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41773202
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41164160
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39600367
88Staphylococcus aureus infection_Homo sapiens_hsa051500.39312706
89Ovarian steroidogenesis_Homo sapiens_hsa049130.38596636
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37064610
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36495340
92Pancreatic cancer_Homo sapiens_hsa052120.36277662
93Melanoma_Homo sapiens_hsa052180.34526864
94Rheumatoid arthritis_Homo sapiens_hsa053230.31507855
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31369074
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30600936
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29709432
98Regulation of autophagy_Homo sapiens_hsa041400.28904312
99Complement and coagulation cascades_Homo sapiens_hsa046100.28672005
100Salmonella infection_Homo sapiens_hsa051320.28544619

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