PTP4A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1creatine metabolic process (GO:0006600)6.79788548
2regulation of actin filament-based movement (GO:1903115)6.30870193
3proline biosynthetic process (GO:0006561)6.20569495
4response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.06431940
5cardiac muscle hypertrophy (GO:0003300)5.67590570
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.43620572
7response to inactivity (GO:0014854)5.42474065
8striated muscle hypertrophy (GO:0014897)5.37218521
9regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.35806344
10transcription from mitochondrial promoter (GO:0006390)5.26328046
11cellular response to zinc ion (GO:0071294)5.20428984
12DNA deamination (GO:0045006)5.18583859
13regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.10665562
14regulation of cell communication by electrical coupling (GO:0010649)5.09080580
15muscle contraction (GO:0006936)5.07897201
16adult heart development (GO:0007512)5.04765388
17NADH metabolic process (GO:0006734)4.96256676
18cardiac muscle tissue morphogenesis (GO:0055008)4.94676508
19response to muscle activity (GO:0014850)4.90110946
20muscle hypertrophy (GO:0014896)4.89311279
21positive regulation of protein homooligomerization (GO:0032464)4.85321549
22regulation of the force of heart contraction (GO:0002026)4.75324417
23muscle tissue morphogenesis (GO:0060415)4.73983688
24muscle filament sliding (GO:0030049)4.72163636
25actin-myosin filament sliding (GO:0033275)4.72163636
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.65304099
27embryonic process involved in female pregnancy (GO:0060136)4.62622687
28muscle system process (GO:0003012)4.59376475
29regulation of striated muscle contraction (GO:0006942)4.54729140
30sarcomere organization (GO:0045214)4.49151611
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.36306681
32replication fork processing (GO:0031297)4.28467292
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.23208106
34striated muscle adaptation (GO:0014888)4.20993610
35cardiac muscle adaptation (GO:0014887)4.17164154
36cardiac muscle hypertrophy in response to stress (GO:0014898)4.17164154
37muscle hypertrophy in response to stress (GO:0003299)4.17164154
38skeletal muscle fiber development (GO:0048741)4.10619431
39proline metabolic process (GO:0006560)4.05272789
402-oxoglutarate metabolic process (GO:0006103)4.04032820
41heart process (GO:0003015)4.00378967
42heart contraction (GO:0060047)4.00378967
43regulation of skeletal muscle contraction (GO:0014819)4.00285863
44positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.00033912
45maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.98427790
46oxidative demethylation (GO:0070989)3.92023279
47mitotic G1 DNA damage checkpoint (GO:0031571)3.89085154
48regulation of membrane repolarization (GO:0060306)3.84189737
49myotube cell development (GO:0014904)3.78065749
50skeletal muscle contraction (GO:0003009)3.76426245
51regulation of calcium ion transmembrane transporter activity (GO:1901019)3.74152905
52regulation of calcium ion transmembrane transport (GO:1903169)3.74152905
53muscle fiber development (GO:0048747)3.73894449
54myofibril assembly (GO:0030239)3.73727197
55dosage compensation (GO:0007549)3.70573870
56cardiac myofibril assembly (GO:0055003)3.69544412
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69498143
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.68642663
59regulation of integrin activation (GO:0033623)3.68496897
60glucan catabolic process (GO:0009251)3.67843895
61tricarboxylic acid cycle (GO:0006099)3.66848034
62regulation of protein homooligomerization (GO:0032462)3.66167526
63regulation of ATP catabolic process (GO:1903289)3.61187884
64regulation of ATPase activity (GO:0043462)3.61187884
65mitochondrial DNA metabolic process (GO:0032042)3.60757487
66glucan biosynthetic process (GO:0009250)3.60726006
67glycogen biosynthetic process (GO:0005978)3.60726006
68ventricular cardiac muscle cell action potential (GO:0086005)3.58280007
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57974681
70actin-mediated cell contraction (GO:0070252)3.57757641
71telomere maintenance via semi-conservative replication (GO:0032201)3.55819708
72muscle adaptation (GO:0043500)3.51806056
73heme biosynthetic process (GO:0006783)3.49783717
74regulation of translational fidelity (GO:0006450)3.46779092
75cardiac muscle contraction (GO:0060048)3.46526582
76cellular polysaccharide catabolic process (GO:0044247)3.44841630
77striated muscle cell development (GO:0055002)3.40103461
78skeletal muscle tissue development (GO:0007519)3.39895514
79porphyrin-containing compound biosynthetic process (GO:0006779)3.39650519
80regulation of muscle contraction (GO:0006937)3.39156718
81negative regulation of necroptotic process (GO:0060546)3.37940358
82regulation of cardiac muscle cell contraction (GO:0086004)3.34871588
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34140735
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32630632
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.32630632
86negative regulation of calcium ion transmembrane transport (GO:1903170)3.32459755
87negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.32459755
88oxidative phosphorylation (GO:0006119)3.32247467
89G1 DNA damage checkpoint (GO:0044783)3.30384215
90regulation of muscle system process (GO:0090257)3.29113347
91regulation of heart rate (GO:0002027)3.27995861
92oxaloacetate metabolic process (GO:0006107)3.26613229
93negative regulation of RNA splicing (GO:0033119)3.25816770
94apoptotic process involved in morphogenesis (GO:0060561)3.25697428
95fatty acid transmembrane transport (GO:1902001)3.23647178
96negative regulation of potassium ion transmembrane transport (GO:1901380)3.22512094
97negative regulation of potassium ion transport (GO:0043267)3.22223200
98relaxation of cardiac muscle (GO:0055119)3.21572700
99mitotic G1/S transition checkpoint (GO:0044819)3.19715192
100base-excision repair (GO:0006284)3.18991494
101regulation of sequestering of triglyceride (GO:0010889)3.18837875
102negative regulation of mRNA processing (GO:0050686)3.18582900
103positive regulation by host of viral transcription (GO:0043923)3.18265501
104cardiac ventricle formation (GO:0003211)3.18204386
105positive regulation of cation channel activity (GO:2001259)3.17266909
106regulation of heart contraction (GO:0008016)3.17064998
107striated muscle contraction (GO:0006941)3.17046142
108muscle cell cellular homeostasis (GO:0046716)3.16669631
109mitochondrial genome maintenance (GO:0000002)3.16338524
110cardiac chamber formation (GO:0003207)3.16243751
111formation of translation preinitiation complex (GO:0001731)3.14844020
112striated muscle atrophy (GO:0014891)3.14474274
113positive regulation of lamellipodium assembly (GO:0010592)3.11180712
114cardiac muscle cell development (GO:0055013)3.10972864
115succinate metabolic process (GO:0006105)3.09842564
116glycogen metabolic process (GO:0005977)3.09706311
117mitochondrial fusion (GO:0008053)3.06505722
118negative regulation of stress fiber assembly (GO:0051497)3.06265847
119negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.05936889
120polysaccharide catabolic process (GO:0000272)3.05639013
121positive regulation of protein oligomerization (GO:0032461)3.05550230
122gluconeogenesis (GO:0006094)3.05454855
123glucan metabolic process (GO:0044042)3.04607337
124cellular glucan metabolic process (GO:0006073)3.04607337
125establishment of apical/basal cell polarity (GO:0035089)3.03443075
126carnitine shuttle (GO:0006853)3.02733178
127nucleotide-excision repair, DNA gap filling (GO:0006297)3.02484265
128viral mRNA export from host cell nucleus (GO:0046784)3.02209061
129mRNA cleavage (GO:0006379)3.00605265
130positive regulation of gamma-delta T cell activation (GO:0046645)3.00214455
131tetrapyrrole biosynthetic process (GO:0033014)2.99277376
132DNA strand elongation involved in DNA replication (GO:0006271)2.97451703
133viral transcription (GO:0019083)2.97153795
134B cell receptor signaling pathway (GO:0050853)2.96073937
135skeletal muscle adaptation (GO:0043501)2.94286956
136plasma membrane repair (GO:0001778)2.93797740
137embryonic placenta development (GO:0001892)2.93263709
138poly(A)+ mRNA export from nucleus (GO:0016973)2.92058871
139positive regulation of B cell differentiation (GO:0045579)2.91863702
140sarcoplasmic reticulum calcium ion transport (GO:0070296)2.91726771
141cardiac cell development (GO:0055006)2.90777861
142oxygen transport (GO:0015671)2.88526191
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.88246057
144regulation of relaxation of muscle (GO:1901077)2.87758709
145regulation of gamma-delta T cell differentiation (GO:0045586)2.85539137
146actin filament-based movement (GO:0030048)2.84314388
147intracellular estrogen receptor signaling pathway (GO:0030520)2.83863282
148positive regulation of myotube differentiation (GO:0010831)2.82882698
149DNA demethylation (GO:0080111)2.82643670
150erythrocyte maturation (GO:0043249)2.80916507
151DNA strand elongation (GO:0022616)2.80476388
152DNA strand renaturation (GO:0000733)2.80047954
153DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.78520710
154DNA topological change (GO:0006265)2.78009330
155mitochondrial RNA metabolic process (GO:0000959)2.77309866
156telomere maintenance via recombination (GO:0000722)2.77268183
157actomyosin structure organization (GO:0031032)2.72855746
158regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.71903924
159positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.71727452
160translational termination (GO:0006415)2.71008410
161negative regulation of erythrocyte differentiation (GO:0045647)2.70154736
162retinoic acid receptor signaling pathway (GO:0048384)2.69518688
1633-UTR-mediated mRNA stabilization (GO:0070935)2.69173803
164translational elongation (GO:0006414)2.68964882
165negative regulation of mRNA metabolic process (GO:1903312)2.65870196
166glycogen catabolic process (GO:0005980)2.65788586
167V(D)J recombination (GO:0033151)2.61963720
168regulation of protein oligomerization (GO:0032459)2.60666159
169negative regulation of cell cycle arrest (GO:0071157)2.58014102
170termination of RNA polymerase II transcription (GO:0006369)2.57747600
171protoporphyrinogen IX metabolic process (GO:0046501)2.53768311
172antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53048336
173antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53048336
174positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52413878
175negative regulation of nucleotide catabolic process (GO:0030812)2.52313696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.44347835
2MYC_22102868_ChIP-Seq_BL_Human3.74760978
3E2F7_22180533_ChIP-Seq_HELA_Human3.57788077
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55647928
5VDR_21846776_ChIP-Seq_THP-1_Human3.51928124
6EZH2_22144423_ChIP-Seq_EOC_Human3.40490997
7* TBX20_22080862_ChIP-Seq_HEART_Mouse2.90135476
8* TBX20_22328084_ChIP-Seq_HEART_Mouse2.90135476
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.39413960
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.36929095
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20705955
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15313892
13KDM2B_26808549_Chip-Seq_DND41_Human2.11815780
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.06488072
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04456859
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02857754
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02225216
18* LXR_22292898_ChIP-Seq_THP-1_Human2.02211486
19MAF_26560356_Chip-Seq_TH1_Human2.00537549
20* TCF7_22412390_ChIP-Seq_EML_Mouse2.00121174
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.95218291
22* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.92072002
23MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.87519214
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86925506
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85080651
26ZNF263_19887448_ChIP-Seq_K562_Human1.84790910
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84511235
28UTX_26944678_Chip-Seq_JUKART_Human1.83779198
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83408455
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82091467
31SCL_19346495_ChIP-Seq_HPC-7_Human1.81855576
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.79686710
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78533174
34CTCF_27219007_Chip-Seq_Bcells_Human1.71556015
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.71304937
36VDR_24763502_ChIP-Seq_THP-1_Human1.70484651
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66906673
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66137233
39DROSHA_22980978_ChIP-Seq_HELA_Human1.64882905
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64228977
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62821981
42* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62627205
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60032811
44* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59348598
45PU.1_20513432_ChIP-Seq_Bcells_Mouse1.56268994
46* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56163750
47CIITA_25753668_ChIP-Seq_RAJI_Human1.55408703
48* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.55218553
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54932767
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54854431
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52461211
52* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51711943
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50183568
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.49071835
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48636818
56MAF_26560356_Chip-Seq_TH2_Human1.48357417
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46627453
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.46517656
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45859683
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45597215
61CLOCK_20551151_ChIP-Seq_293T_Human1.44790482
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44619484
63CTCF_21964334_ChIP-Seq_BJAB-B_Human1.43808499
64GATA1_22025678_ChIP-Seq_K562_Human1.43006574
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42747389
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41676665
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41139596
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.38998584
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.36049763
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35971767
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35780840
72* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33853804
73* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33771117
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32621293
75P68_20966046_ChIP-Seq_HELA_Human1.31437554
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31249225
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.31227786
78RACK7_27058665_Chip-Seq_MCF-7_Human1.30422233
79* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30317640
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29354451
81* BCL6_27268052_Chip-Seq_Bcells_Human1.28743486
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27155116
83KDM2B_26808549_Chip-Seq_K562_Human1.26733995
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26435561
85* SMC4_20622854_ChIP-Seq_HELA_Human1.26293628
86BCOR_27268052_Chip-Seq_Bcells_Human1.25955791
87* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25075273
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25009581
89SA1_27219007_Chip-Seq_Bcells_Human1.24996892
90MYB_26560356_Chip-Seq_TH1_Human1.24639031
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24254415
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24225506
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.23657521
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.22587167
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21681267
96NCOR1_26117541_ChIP-Seq_K562_Human1.21514485
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.20069700
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19520750
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19275733
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19177201
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18590137
102IRF8_22096565_ChIP-ChIP_GC-B_Human1.17828235
103RXR_22158963_ChIP-Seq_LIVER_Mouse1.17585961
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17577552
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16515693
106GATA1_19941826_ChIP-Seq_K562_Human1.15791288
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15661984
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15185246
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14885522
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12771963
111* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12675602
112ETS1_20019798_ChIP-Seq_JURKAT_Human1.12515882
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12353377
114CTCF_21964334_Chip-Seq_Bcells_Human1.11030416
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10946935
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10664262
117* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10625398
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.10551796
119* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10098855
120* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09371659
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09102894
122STAT1_20625510_ChIP-Seq_HELA_Human1.08830515
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.08710238
124MYB_26560356_Chip-Seq_TH2_Human1.08616544
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.08086799
126CREB1_26743006_Chip-Seq_LNCaP_Human1.07846976
127XRN2_22483619_ChIP-Seq_HELA_Human1.07711873
128* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07258685
129* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06879364
130E2F1_20622854_ChIP-Seq_HELA_Human1.06622100
131JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06450982
132ERG_21242973_ChIP-ChIP_JURKAT_Human1.06175657
133ETS1_21867929_ChIP-Seq_TH2_Mouse1.05212108
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05007018
135SPI1_23127762_ChIP-Seq_K562_Human1.04577058
136PHF8_20622854_ChIP-Seq_HELA_Human1.04314735
137KDM5A_27292631_Chip-Seq_BREAST_Human1.03710217
138SPI1_23547873_ChIP-Seq_NB4_Human1.03120786
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03070097
140MYC_27129775_Chip-Seq_CORNEA_Mouse1.02722652
141EZH2_27294783_Chip-Seq_ESCs_Mouse1.02589146
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02183071
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01958274
144PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00831637
145GABP_19822575_ChIP-Seq_HepG2_Human1.00456674
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98830005
147SPI1_20517297_ChIP-Seq_HL60_Human0.98798916
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98266414
149EGR1_19374776_ChIP-ChIP_THP-1_Human0.98151101
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98092474
151NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97880091
152NOTCH1_21737748_ChIP-Seq_TLL_Human0.97811152
153YY1_21170310_ChIP-Seq_MESCs_Mouse0.97709724
154CTCF_26484167_Chip-Seq_Bcells_Mouse0.97154553
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97006614
156RUNX_20019798_ChIP-Seq_JUKART_Human0.96627663
157MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96487531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.23138012
2MP0000751_myopathy3.66597337
3MP0005451_abnormal_body_composition3.17231710
4MP0009278_abnormal_bone_marrow3.12067176
5MP0000749_muscle_degeneration3.01830880
6MP0004233_abnormal_muscle_weight2.98852744
7MP0002837_dystrophic_cardiac_calcinosis2.96647224
8MP0008057_abnormal_DNA_replication2.88188799
9MP0005330_cardiomyopathy2.69642250
10MP0004145_abnormal_muscle_electrophysio2.67498237
11MP0004084_abnormal_cardiac_muscle2.56304926
12MP0003656_abnormal_erythrocyte_physiolo2.45901263
13MP0004036_abnormal_muscle_relaxation2.42932874
14MP0004087_abnormal_muscle_fiber2.40733295
15MP0002269_muscular_atrophy2.39947277
16MP0002106_abnormal_muscle_physiology2.39300690
17MP0000685_abnormal_immune_system2.21697879
18MP0006138_congestive_heart_failure2.13510121
19MP0001545_abnormal_hematopoietic_system2.13429916
20MP0005397_hematopoietic_system_phenotyp2.13429916
21MP0002396_abnormal_hematopoietic_system2.12564206
22MP0010630_abnormal_cardiac_muscle2.05003268
23MP0000759_abnormal_skeletal_muscle2.01284648
24MP0000747_muscle_weakness2.00320428
25MP0004215_abnormal_myocardial_fiber1.98035263
26MP0000750_abnormal_muscle_regeneration1.95595692
27MP0003828_pulmonary_edema1.95296241
28MP0004130_abnormal_muscle_cell1.87829235
29MP0005369_muscle_phenotype1.84183240
30MP0010094_abnormal_chromosome_stability1.71863558
31MP0006036_abnormal_mitochondrial_physio1.61837938
32MP0003763_abnormal_thymus_physiology1.61605425
33MP0008775_abnormal_heart_ventricle1.58246471
34MP0000013_abnormal_adipose_tissue1.57965972
35MP0003137_abnormal_impulse_conducting1.57163184
36MP0008995_early_reproductive_senescence1.55399401
37MP0002398_abnormal_bone_marrow1.51902424
38MP0005620_abnormal_muscle_contractility1.51066129
39MP0003567_abnormal_fetal_cardiomyocyte1.47399903
40MP0005670_abnormal_white_adipose1.47373860
41MP0002108_abnormal_muscle_morphology1.45670724
42MP0006072_abnormal_retinal_apoptosis1.43665467
43MP0000689_abnormal_spleen_morphology1.43283448
44MP0002332_abnormal_exercise_endurance1.40168823
45MP0004085_abnormal_heartbeat1.38432427
46MP0004808_abnormal_hematopoietic_stem1.38337743
47MP0001800_abnormal_humoral_immune1.33389703
48MP0003111_abnormal_nucleus_morphology1.32389672
49MP0010368_abnormal_lymphatic_system1.26876203
50MP0002722_abnormal_immune_system1.26851527
51MP0001544_abnormal_cardiovascular_syste1.26310227
52MP0005385_cardiovascular_system_phenoty1.26310227
53MP0004147_increased_porphyrin_level1.26265429
54MP0000490_abnormal_crypts_of1.26163578
55MP0002166_altered_tumor_susceptibility1.22936911
56MP0003221_abnormal_cardiomyocyte_apopto1.22446669
57MP0003077_abnormal_cell_cycle1.21998033
58MP0000703_abnormal_thymus_morphology1.21268374
59MP0005167_abnormal_blood-brain_barrier1.18702397
60MP0002972_abnormal_cardiac_muscle1.15649999
61MP0002019_abnormal_tumor_incidence1.14330358
62MP0010352_gastrointestinal_tract_polyps1.11499221
63MP0002009_preneoplasia1.11057810
64MP0002405_respiratory_system_inflammati1.10800265
65MP0004957_abnormal_blastocyst_morpholog1.10539650
66MP0009333_abnormal_splenocyte_physiolog1.07832717
67MP0005375_adipose_tissue_phenotype1.06595255
68MP0002429_abnormal_blood_cell1.05668790
69MP0000266_abnormal_heart_morphology1.04999676
70MP0008058_abnormal_DNA_repair1.04666648
71MP0000716_abnormal_immune_system1.04344015
72MP0001790_abnormal_immune_system1.04336344
73MP0005387_immune_system_phenotype1.04336344
74MP0004484_altered_response_of1.02222314
75MP0002127_abnormal_cardiovascular_syste1.01488208
76MP0004185_abnormal_adipocyte_glucose1.00149502
77MP0000003_abnormal_adipose_tissue1.00139477
78MP0003786_premature_aging1.00092030
79MP0001835_abnormal_antigen_presentation0.97867079
80MP0005076_abnormal_cell_differentiation0.97129970
81MP0005174_abnormal_tail_pigmentation0.94039615
82MP0005165_increased_susceptibility_to0.93206477
83MP0005266_abnormal_metabolism0.92314641
84MP0002452_abnormal_antigen_presenting0.90635637
85MP0000733_abnormal_muscle_development0.90166059
86MP0002971_abnormal_brown_adipose0.89107367
87MP0000350_abnormal_cell_proliferation0.89056149
88MP0002086_abnormal_extraembryonic_tissu0.88214399
89MP0004510_myositis0.88069097
90MP0002420_abnormal_adaptive_immunity0.87944822
91MP0001697_abnormal_embryo_size0.87772112
92MP0000343_altered_response_to0.85872522
93MP0000313_abnormal_cell_death0.85138952
94MP0005666_abnormal_adipose_tissue0.84701556
95MP0001819_abnormal_immune_cell0.84378015
96MP0003045_fibrosis0.82720855
97MP0001661_extended_life_span0.82599159
98MP0001879_abnormal_lymphatic_vessel0.81887754
99MP0004197_abnormal_fetal_growth/weight/0.81213433
100MP0003984_embryonic_growth_retardation0.80502449
101MP0001672_abnormal_embryogenesis/_devel0.77854230
102MP0005380_embryogenesis_phenotype0.77854230
103MP0004270_analgesia0.77133183
104MP0001873_stomach_inflammation0.76985314
105MP0010155_abnormal_intestine_physiology0.76840541
106MP0002723_abnormal_immune_serum0.76631216
107MP0003693_abnormal_embryo_hatching0.75862898
108MP0002080_prenatal_lethality0.75680360
109MP0010307_abnormal_tumor_latency0.75642535
110MP0003566_abnormal_cell_adhesion0.75205385
111MP0002088_abnormal_embryonic_growth/wei0.75142592
112MP0005464_abnormal_platelet_physiology0.74081693
113MP0001730_embryonic_growth_arrest0.73808408
114MP0003303_peritoneal_inflammation0.73315439
115MP0001784_abnormal_fluid_regulation0.72933019
116MP0003724_increased_susceptibility_to0.67206730
117MP0002128_abnormal_blood_circulation0.67059510
118MP0002822_catalepsy0.58607059
119MP0005535_abnormal_body_temperature0.55358992
120MP0002078_abnormal_glucose_homeostasis0.54655194
121MP0003279_aneurysm0.52666805
122MP0003879_abnormal_hair_cell0.52547822
123MP0008569_lethality_at_weaning0.51702092
124MP0003948_abnormal_gas_homeostasis0.45827350
125MP0000767_abnormal_smooth_muscle0.42532814
126MP0008874_decreased_physiological_sensi0.40598276
127MP0002933_joint_inflammation0.40501822
128MP0000230_abnormal_systemic_arterial0.40057308
129MP0002638_abnormal_pupillary_reflex0.38995509
130MP0009840_abnormal_foam_cell0.38622927
131MP0000249_abnormal_blood_vessel0.37028214
132MP0000372_irregular_coat_pigmentation0.36961486
133MP0008260_abnormal_autophagy0.36888334
134MP0005584_abnormal_enzyme/coenzyme_acti0.36078673
135MP0002138_abnormal_hepatobiliary_system0.34991957
136MP0005409_darkened_coat_color0.34460941
137MP0005083_abnormal_biliary_tract0.34056367
138MP0009780_abnormal_chondrocyte_physiolo0.33289563
139MP0005334_abnormal_fat_pad0.32953988
140MP0000465_gastrointestinal_hemorrhage0.32472586
141MP0005166_decreased_susceptibility_to0.30972642
142MP0006035_abnormal_mitochondrial_morpho0.30454187
143MP0002925_abnormal_cardiovascular_devel0.29052692
144MP0001614_abnormal_blood_vessel0.26789565
145MP0005319_abnormal_enzyme/_coenzyme0.26395215
146MP0005376_homeostasis/metabolism_phenot0.23720460
147MP0009115_abnormal_fat_cell0.23284245
148MP0005452_abnormal_adipose_tissue0.20787716
149MP0003705_abnormal_hypodermis_morpholog0.20229451
150MP0003300_gastrointestinal_ulcer0.19781102
151MP0008004_abnormal_stomach_pH0.18256259
152MP0009672_abnormal_birth_weight0.18237796
153MP0001943_abnormal_respiration0.18212321

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.25557161
2Centrally nucleated skeletal muscle fibers (HP:0003687)5.20345414
3Exercise-induced muscle cramps (HP:0003710)4.92079043
4Bundle branch block (HP:0011710)4.65365928
5Distal lower limb muscle weakness (HP:0009053)4.41604610
6Muscle hypertrophy of the lower extremities (HP:0008968)4.31370382
7Sudden death (HP:0001699)4.29052693
8Myoglobinuria (HP:0002913)4.26879614
9Calf muscle hypertrophy (HP:0008981)4.26538766
10Rimmed vacuoles (HP:0003805)4.17432898
11Muscle fiber inclusion bodies (HP:0100299)4.05228143
12Asymmetric septal hypertrophy (HP:0001670)3.95213340
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.88307145
14Increased variability in muscle fiber diameter (HP:0003557)3.83168844
15Subaortic stenosis (HP:0001682)3.81003870
16Abnormality of the left ventricular outflow tract (HP:0011103)3.81003870
17Ventricular tachycardia (HP:0004756)3.70264552
18Muscle fiber splitting (HP:0003555)3.57864754
19Pustule (HP:0200039)3.37170187
20Nemaline bodies (HP:0003798)3.32141403
21Hyporeflexia of lower limbs (HP:0002600)3.28817911
22Rhabdomyolysis (HP:0003201)3.25742587
23Type 1 muscle fiber predominance (HP:0003803)3.17787466
24Agammaglobulinemia (HP:0004432)3.12420628
25Myotonia (HP:0002486)3.10826412
26Poikiloderma (HP:0001029)3.09358646
27Difficulty running (HP:0009046)3.09033652
28Colitis (HP:0002583)3.06812658
29Heart block (HP:0012722)3.06306007
30Increased connective tissue (HP:0009025)3.03433213
31EMG: myopathic abnormalities (HP:0003458)3.01810377
32Abnormality of the calf musculature (HP:0001430)3.01395451
33Polycythemia (HP:0001901)2.96690017
34Distal lower limb amyotrophy (HP:0008944)2.95689283
35Distal arthrogryposis (HP:0005684)2.93482069
36Round ear (HP:0100830)2.93211880
37Frequent falls (HP:0002359)2.91762200
38Generalized muscle weakness (HP:0003324)2.90322485
39Abnormal atrioventricular conduction (HP:0005150)2.89161070
40Mildly elevated creatine phosphokinase (HP:0008180)2.87515476
41Muscle stiffness (HP:0003552)2.83429060
42Verrucae (HP:0200043)2.82666775
43Papilloma (HP:0012740)2.82666775
44Myopathic facies (HP:0002058)2.81988049
45Ulnar deviation of the wrist (HP:0003049)2.81649815
46Ragged-red muscle fibers (HP:0003200)2.80628264
47Large for gestational age (HP:0001520)2.80135152
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79500116
49Lipoatrophy (HP:0100578)2.79012292
50Syncope (HP:0001279)2.77611402
51Hypochromic microcytic anemia (HP:0004840)2.77394209
52Calcaneovalgus deformity (HP:0001848)2.72274315
53Abnormality of the foot musculature (HP:0001436)2.69714430
54Cellulitis (HP:0100658)2.66806699
55Difficulty climbing stairs (HP:0003551)2.65865163
56Gastrointestinal inflammation (HP:0004386)2.64646592
57Inflammation of the large intestine (HP:0002037)2.62016293
58Ulnar bowing (HP:0003031)2.61928600
59Atrial fibrillation (HP:0005110)2.61371824
60Absent phalangeal crease (HP:0006109)2.60499627
61Ventricular fibrillation (HP:0001663)2.59605045
62Basal cell carcinoma (HP:0002671)2.58909656
63Neck muscle weakness (HP:0000467)2.57899308
64Hypochromic anemia (HP:0001931)2.57053894
65Supraventricular tachycardia (HP:0004755)2.54423513
66Areflexia of lower limbs (HP:0002522)2.54256399
67Primary atrial arrhythmia (HP:0001692)2.52081961
68Diaphragmatic weakness (HP:0009113)2.49674863
69Supraventricular arrhythmia (HP:0005115)2.49120011
70Annular pancreas (HP:0001734)2.47907306
71IgM deficiency (HP:0002850)2.46578591
72Scapular winging (HP:0003691)2.45168335
73Bulbar palsy (HP:0001283)2.41924504
74Foot dorsiflexor weakness (HP:0009027)2.39815406
75Deformed tarsal bones (HP:0008119)2.39807751
76Recurrent bronchitis (HP:0002837)2.37253373
77Rib fusion (HP:0000902)2.30634827
78Bony spicule pigmentary retinopathy (HP:0007737)2.29528330
79Atrioventricular block (HP:0001678)2.27186837
80Right ventricular cardiomyopathy (HP:0011663)2.27055872
81Abnormal number of erythroid precursors (HP:0012131)2.26112173
82EMG: neuropathic changes (HP:0003445)2.24760139
83Muscle fiber atrophy (HP:0100295)2.22011026
84Limb-girdle muscle atrophy (HP:0003797)2.21757298
85Congenital hip dislocation (HP:0001374)2.21451631
86Dilated cardiomyopathy (HP:0001644)2.19697416
87Progressive muscle weakness (HP:0003323)2.16253318
88Lower limb amyotrophy (HP:0007210)2.14771658
89Poikilocytosis (HP:0004447)2.14565393
90Pancreatic islet-cell hyperplasia (HP:0004510)2.12393794
91Muscle fibrillation (HP:0010546)2.11422010
92Albinism (HP:0001022)2.10531727
93Abnormal rod and cone electroretinograms (HP:0008323)2.09252125
94Malignant hyperthermia (HP:0002047)2.09040291
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.08988593
96IgA deficiency (HP:0002720)2.08479288
97Prolonged QT interval (HP:0001657)2.07858920
98Abnormality of cells of the erythroid lineage (HP:0012130)2.07630480
99Muscular dystrophy (HP:0003560)2.07529535
100Gowers sign (HP:0003391)2.06581780
101Panhypogammaglobulinemia (HP:0003139)2.06164049
102Abnormality of T cell physiology (HP:0011840)2.04797881
103Cerebral aneurysm (HP:0004944)2.04422678
104Increased IgM level (HP:0003496)2.03691038
105Abnormal finger flexion creases (HP:0006143)2.03241071
106Intestinal fistula (HP:0100819)2.02599062
107Abnormal EKG (HP:0003115)2.02295500
108Slender build (HP:0001533)1.99022212
109Abnormality of skeletal muscle fiber size (HP:0012084)1.98230890
110Type 2 muscle fiber atrophy (HP:0003554)1.97206574
111Easy fatigability (HP:0003388)1.96504568
112Abnormality of the neuromuscular junction (HP:0003398)1.96492681
113Fatigable weakness (HP:0003473)1.96492681
114Abnormality of the nasal mucosa (HP:0000433)1.95500259
115Palpitations (HP:0001962)1.95443684
116Spinal rigidity (HP:0003306)1.94344106
117Acute lymphatic leukemia (HP:0006721)1.92250879
118Waddling gait (HP:0002515)1.92180317
119Gastrointestinal stroma tumor (HP:0100723)1.91718069
120Paralysis (HP:0003470)1.91050277
121Squamous cell carcinoma (HP:0002860)1.90623061
122Hip contracture (HP:0003273)1.88439948
123Hyperkalemia (HP:0002153)1.86228593
124Abnormality of the shoulder girdle musculature (HP:0001435)1.85015553
125Hypoplastic ischia (HP:0003175)1.84173869
126Proximal amyotrophy (HP:0007126)1.82858628
127Abnormality of the fingertips (HP:0001211)1.82369743
128Weak cry (HP:0001612)1.82327064
129Ventricular arrhythmia (HP:0004308)1.80893560
130Rectovaginal fistula (HP:0000143)1.80794619
131Rectal fistula (HP:0100590)1.80794619
132Microcytic anemia (HP:0001935)1.80058046
133Abnormality of the calcaneus (HP:0008364)1.79988023
134Left ventricular hypertrophy (HP:0001712)1.79577728
135Fetal akinesia sequence (HP:0001989)1.75722356
136Increased intramyocellular lipid droplets (HP:0012240)1.74665141
137Increased muscle lipid content (HP:0009058)1.73515185
138Exercise intolerance (HP:0003546)1.72816894
139Respiratory insufficiency due to muscle weakness (HP:0002747)1.71237371
140Steppage gait (HP:0003376)1.65227337
141Sudden cardiac death (HP:0001645)1.56075240
142Limb-girdle muscle weakness (HP:0003325)1.47450384
143Palmoplantar keratoderma (HP:0000982)1.46480739
144Abnormality of the tricuspid valve (HP:0001702)1.45619937
145Dysmetric saccades (HP:0000641)1.45531975
146Abnormality of the endocardium (HP:0004306)1.44445961
147Facial diplegia (HP:0001349)1.43296480
148Abnormality of the hip-girdle musculature (HP:0001445)1.37305897
149Abnormality of the musculature of the pelvis (HP:0001469)1.37305897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.97574131
2ICK3.62617197
3TTN2.98241828
4MAP4K12.77639005
5MAP3K112.69231013
6PHKG22.65182032
7PHKG12.65182032
8PINK12.64470349
9TRIB32.62159421
10EEF2K2.60583081
11MAP3K62.47273102
12MAPK152.25118604
13OBSCN2.15516082
14PKN21.97368064
15DDR21.89204519
16PIM21.86578611
17PRKD21.71394199
18MATK1.70219675
19MAP2K31.55139449
20ERN11.52862951
21FLT31.51720719
22MAPKAPK31.49734574
23DYRK1B1.49198957
24TRPM71.48965793
25MAPK111.46403392
26CSK1.37175835
27EPHB11.33237231
28PIM11.32710681
29DMPK1.28046492
30FGR1.25016296
31RPS6KL11.18678465
32RPS6KC11.18678465
33PRPF4B1.17336324
34EPHA31.16288353
35RPS6KB21.14276070
36PDGFRA1.11193133
37UHMK11.10789281
38RPS6KA61.10661748
39DAPK11.09122018
40DYRK31.06321191
41BMX1.05302298
42MAPK121.05274194
43MAP2K61.05176277
44MAP3K131.03809367
45BTK1.01949601
46CDK71.01838999
47SIK21.00994046
48KSR21.00636870
49NEK11.00119230
50CDC42BPA0.99437702
51TYRO30.98868889
52TGFBR20.97939183
53CDK120.95570727
54SYK0.93279279
55GRK60.92780651
56MAP2K40.91346703
57STK40.90901893
58NME20.90625182
59HIPK20.89707505
60TIE10.89317996
61MAP3K70.88993917
62STK100.88920323
63FGFR40.88841610
64MAPK70.88327645
65NEK20.85923511
66CSF1R0.85800525
67TAOK10.84763549
68CDK40.84714467
69CAMK40.84175607
70MARK10.82595542
71LRRK20.82073331
72PRKAA10.81987157
73MARK20.81358324
74TAOK20.81080672
75CDK60.79219089
76MAP3K10.78671206
77STK240.77585189
78RIPK40.77269780
79BCKDK0.76244290
80KDR0.74943497
81ZAP700.69491878
82MYLK0.68475004
83KIT0.65328948
84PRKD10.65235425
85LYN0.64699102
86NEK90.63987472
87CAMK2D0.63566224
88MAPK40.62243221
89YES10.62229732
90CAMK10.61923090
91CAMK2G0.61758625
92PRKAA20.60654911
93ILK0.60237798
94PAK30.59948682
95RPS6KA10.58956936
96TNK20.58696715
97RIPK10.55432126
98PKN10.54677510
99ROCK10.54171789
100PDPK10.53784561
101MTOR0.52466652
102PDK30.51910758
103PDK40.51910758
104MAPKAPK20.51397631
105PIK3CA0.49121764
106AKT20.47576287
107CCNB10.47197511
108BLK0.47042564
109MAP2K10.45494547
110LCK0.45147938
111FGFR30.43662600
112PDK20.41353046
113FES0.41135849
114TLK10.40917223
115PRKG10.40898490
116JAK30.40701498
117PDK10.39629290
118CAMK2A0.39119428
119TGFBR10.38248759
120HCK0.37858534
121MOS0.37688478
122PIK3CG0.37552275
123MUSK0.36994750
124TYK20.36791373
125SGK30.36692788
126MARK30.36030554
127TBK10.34944820
128ATR0.33933384
129ARAF0.33520947
130CHEK20.33494160
131NME10.33480252
132LIMK10.33225697
133RAF10.32901342
134IKBKB0.32014632
135MAPK30.31314060
136DAPK20.31174791
137GSK3A0.30342749
138MAP3K50.30127671
139SIK10.29687500
140MAP3K30.28835445
141MAPK100.28395996
142PRKACA0.28089759
143ROCK20.27207468
144RPS6KA20.26254453
145PTK2B0.25112062
146RET0.24853863
147PTK60.24670880

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034103.64757796
2Mismatch repair_Homo sapiens_hsa034303.37445332
3DNA replication_Homo sapiens_hsa030303.36322263
4Primary immunodeficiency_Homo sapiens_hsa053403.15103110
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56114354
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47551736
7Fatty acid biosynthesis_Homo sapiens_hsa000612.22075737
8B cell receptor signaling pathway_Homo sapiens_hsa046622.20047232
9Ribosome_Homo sapiens_hsa030101.97600932
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86450290
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76012558
12Viral myocarditis_Homo sapiens_hsa054161.70963523
13Cardiac muscle contraction_Homo sapiens_hsa042601.70543802
14Nucleotide excision repair_Homo sapiens_hsa034201.69550315
15Spliceosome_Homo sapiens_hsa030401.68631713
16Phototransduction_Homo sapiens_hsa047441.68096927
17Arginine biosynthesis_Homo sapiens_hsa002201.65462409
18Dilated cardiomyopathy_Homo sapiens_hsa054141.63044977
19mTOR signaling pathway_Homo sapiens_hsa041501.55605035
20Notch signaling pathway_Homo sapiens_hsa043301.48328474
21Calcium signaling pathway_Homo sapiens_hsa040201.40775832
22Circadian rhythm_Homo sapiens_hsa047101.40700054
23mRNA surveillance pathway_Homo sapiens_hsa030151.37354483
24Acute myeloid leukemia_Homo sapiens_hsa052211.35704239
25Homologous recombination_Homo sapiens_hsa034401.32174009
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31411577
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29467122
28Chronic myeloid leukemia_Homo sapiens_hsa052201.29081755
29VEGF signaling pathway_Homo sapiens_hsa043701.23650152
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22439600
31Sulfur relay system_Homo sapiens_hsa041221.22312816
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.21691893
33p53 signaling pathway_Homo sapiens_hsa041151.21592636
34Pentose phosphate pathway_Homo sapiens_hsa000301.21215858
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16671302
36Insulin signaling pathway_Homo sapiens_hsa049101.16562999
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15670690
38RNA transport_Homo sapiens_hsa030131.15186147
39Cell cycle_Homo sapiens_hsa041101.13751078
40Biosynthesis of amino acids_Homo sapiens_hsa012301.12493504
41GnRH signaling pathway_Homo sapiens_hsa049121.01848624
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01119955
43Fatty acid degradation_Homo sapiens_hsa000711.00223293
44Alzheimers disease_Homo sapiens_hsa050101.00035215
45Renin secretion_Homo sapiens_hsa049240.99769444
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98361056
47Phenylalanine metabolism_Homo sapiens_hsa003600.97942983
48AMPK signaling pathway_Homo sapiens_hsa041520.97801862
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97023246
50Propanoate metabolism_Homo sapiens_hsa006400.93581197
51Shigellosis_Homo sapiens_hsa051310.93294424
52Pyruvate metabolism_Homo sapiens_hsa006200.92315671
53Gastric acid secretion_Homo sapiens_hsa049710.91330773
54Lysine degradation_Homo sapiens_hsa003100.90023545
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89552832
56Herpes simplex infection_Homo sapiens_hsa051680.88793062
57Viral carcinogenesis_Homo sapiens_hsa052030.86678055
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85623119
59HIF-1 signaling pathway_Homo sapiens_hsa040660.85447029
60Insulin resistance_Homo sapiens_hsa049310.85200179
61Small cell lung cancer_Homo sapiens_hsa052220.83226383
62Non-small cell lung cancer_Homo sapiens_hsa052230.82312361
63Measles_Homo sapiens_hsa051620.82257174
64Long-term potentiation_Homo sapiens_hsa047200.80970963
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80911534
66HTLV-I infection_Homo sapiens_hsa051660.80486223
67Carbon metabolism_Homo sapiens_hsa012000.80285940
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.79561789
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78941946
70Fanconi anemia pathway_Homo sapiens_hsa034600.78358304
71Parkinsons disease_Homo sapiens_hsa050120.77817965
72Bladder cancer_Homo sapiens_hsa052190.77338480
73Glucagon signaling pathway_Homo sapiens_hsa049220.76613355
74Adherens junction_Homo sapiens_hsa045200.76121102
75Platelet activation_Homo sapiens_hsa046110.75453114
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73864016
77Tight junction_Homo sapiens_hsa045300.72243970
78Hematopoietic cell lineage_Homo sapiens_hsa046400.69665951
79Arginine and proline metabolism_Homo sapiens_hsa003300.68021497
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68004523
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67685136
82Insulin secretion_Homo sapiens_hsa049110.66874727
83Fructose and mannose metabolism_Homo sapiens_hsa000510.66675796
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65434352
85Oxidative phosphorylation_Homo sapiens_hsa001900.65058507
86Epstein-Barr virus infection_Homo sapiens_hsa051690.64802156
87cAMP signaling pathway_Homo sapiens_hsa040240.64362566
88RNA degradation_Homo sapiens_hsa030180.64249258
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.64173504
90Fatty acid metabolism_Homo sapiens_hsa012120.63902602
91Galactose metabolism_Homo sapiens_hsa000520.63593064
92Hepatitis B_Homo sapiens_hsa051610.62976864
93Colorectal cancer_Homo sapiens_hsa052100.62380742
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62098565
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61767775
96PPAR signaling pathway_Homo sapiens_hsa033200.60172823
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59090835
98Focal adhesion_Homo sapiens_hsa045100.58475673
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58456064
100Systemic lupus erythematosus_Homo sapiens_hsa053220.58288922
101Pancreatic cancer_Homo sapiens_hsa052120.56732951
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55914862
103Legionellosis_Homo sapiens_hsa051340.54781256
104Apoptosis_Homo sapiens_hsa042100.54175286
105Osteoclast differentiation_Homo sapiens_hsa043800.53949969
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52893362
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52189625
108MicroRNAs in cancer_Homo sapiens_hsa052060.51963334
109Circadian entrainment_Homo sapiens_hsa047130.51867396
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.50863895
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.50224073
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49350841
113Non-homologous end-joining_Homo sapiens_hsa034500.48774214
114Renal cell carcinoma_Homo sapiens_hsa052110.48479578
115MAPK signaling pathway_Homo sapiens_hsa040100.48473444
116Cholinergic synapse_Homo sapiens_hsa047250.47825463
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47763804
118FoxO signaling pathway_Homo sapiens_hsa040680.46644704
119Antigen processing and presentation_Homo sapiens_hsa046120.46363765
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46278108
121Starch and sucrose metabolism_Homo sapiens_hsa005000.45874720
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44842951
123Oxytocin signaling pathway_Homo sapiens_hsa049210.44269256
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44066700
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.43357454
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42826705
127Pancreatic secretion_Homo sapiens_hsa049720.42744745
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42687715
129Leishmaniasis_Homo sapiens_hsa051400.41488727
130Olfactory transduction_Homo sapiens_hsa047400.41411697
131Thyroid cancer_Homo sapiens_hsa052160.40907340
132Type II diabetes mellitus_Homo sapiens_hsa049300.39859946
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.39248243
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38816739
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.38292873
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.34280494
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33524445
138Ovarian steroidogenesis_Homo sapiens_hsa049130.32935115
139Amoebiasis_Homo sapiens_hsa051460.31001267
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.27887084
141Estrogen signaling pathway_Homo sapiens_hsa049150.25688273
142Huntingtons disease_Homo sapiens_hsa050160.25409749
143Other glycan degradation_Homo sapiens_hsa005110.25240205
144Amphetamine addiction_Homo sapiens_hsa050310.24622683
145T cell receptor signaling pathway_Homo sapiens_hsa046600.23931319
146Gap junction_Homo sapiens_hsa045400.23299254
147Glioma_Homo sapiens_hsa052140.23142880
148Prolactin signaling pathway_Homo sapiens_hsa049170.22944931
149Salivary secretion_Homo sapiens_hsa049700.22760609
150Long-term depression_Homo sapiens_hsa047300.20341319
151Endometrial cancer_Homo sapiens_hsa052130.19894480
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19331292

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