PTPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.37979098
2Golgi transport vesicle coating (GO:0048200)5.37979098
3protein retention in ER lumen (GO:0006621)4.52559403
4cytoskeletal anchoring at plasma membrane (GO:0007016)4.45505845
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.33642146
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.32855276
7proline biosynthetic process (GO:0006561)4.17360557
8adherens junction assembly (GO:0034333)4.15788906
9focal adhesion assembly (GO:0048041)4.09210400
10cell-substrate adherens junction assembly (GO:0007045)4.09210400
11protein localization to endosome (GO:0036010)3.97625208
12regulation of mammary gland epithelial cell proliferation (GO:0033599)3.91129305
13regulation of early endosome to late endosome transport (GO:2000641)3.90912249
14negative regulation of cell size (GO:0045792)3.89150477
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.88849157
16activation of Rac GTPase activity (GO:0032863)3.60178413
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.57896269
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57068831
19sodium ion export (GO:0071436)3.52272042
20maternal placenta development (GO:0001893)3.46612500
21cell-substrate junction assembly (GO:0007044)3.32912549
22NADH metabolic process (GO:0006734)3.30565406
23barbed-end actin filament capping (GO:0051016)3.22831429
24epithelial cell-cell adhesion (GO:0090136)3.22742101
25pentose-phosphate shunt (GO:0006098)3.21629867
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.19069783
27regulation of glucose import in response to insulin stimulus (GO:2001273)3.17617483
28regulation of translational fidelity (GO:0006450)3.13072237
29positive regulation of synapse maturation (GO:0090129)3.07544305
30positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.04182527
31desmosome organization (GO:0002934)3.01291207
32protein complex localization (GO:0031503)3.00112432
33semaphorin-plexin signaling pathway (GO:0071526)2.97231423
34apoptotic process involved in morphogenesis (GO:0060561)2.96769575
35basement membrane organization (GO:0071711)2.96680276
36glutamate secretion (GO:0014047)2.96169618
37glucose 6-phosphate metabolic process (GO:0051156)2.93407481
38proline metabolic process (GO:0006560)2.92261233
39cellular protein complex localization (GO:0034629)2.89070309
40protein maturation by protein folding (GO:0022417)2.87364498
41protein targeting to plasma membrane (GO:0072661)2.86926390
42peptidyl-arginine omega-N-methylation (GO:0035247)2.86717806
43activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86199005
44glucose catabolic process (GO:0006007)2.85112037
45epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83701625
46positive regulation of nuclease activity (GO:0032075)2.76503191
47NADPH regeneration (GO:0006740)2.74627962
48positive regulation of Cdc42 GTPase activity (GO:0043089)2.71105372
49endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.70382474
50stress fiber assembly (GO:0043149)2.70042607
51regulation of cholesterol biosynthetic process (GO:0045540)2.68914780
52layer formation in cerebral cortex (GO:0021819)2.64491749
53positive regulation of protein dephosphorylation (GO:0035307)2.63739687
54negative regulation of microtubule polymerization (GO:0031115)2.61298447
55regulation of ARF protein signal transduction (GO:0032012)2.58989059
56regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.58666660
57negative regulation of erythrocyte differentiation (GO:0045647)2.57911912
58cell-cell junction maintenance (GO:0045217)2.56949233
59cellular potassium ion homeostasis (GO:0030007)2.55160145
60positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.54498173
61regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.54498173
62modulation by virus of host morphology or physiology (GO:0019048)2.54377026
63vesicle coating (GO:0006901)2.54212173
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.51380201
65monosaccharide biosynthetic process (GO:0046364)2.49875743
66regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.49875087
67DNA unwinding involved in DNA replication (GO:0006268)2.49302860
68endoplasmic reticulum unfolded protein response (GO:0030968)2.49281071
69establishment of apical/basal cell polarity (GO:0035089)2.48441504
70gluconeogenesis (GO:0006094)2.45092461
71mitotic chromosome condensation (GO:0007076)2.44055806
72regulation of nuclease activity (GO:0032069)2.43884183
73cerebellar granule cell differentiation (GO:0021707)2.43669221
74intracellular estrogen receptor signaling pathway (GO:0030520)2.43280775
75cerebellar Purkinje cell layer development (GO:0021680)2.42729299
76embryo implantation (GO:0007566)2.42266431
77adenine nucleotide transport (GO:0051503)2.41695063
78ER-nucleus signaling pathway (GO:0006984)2.41642326
79regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41206775
80branching involved in mammary gland duct morphogenesis (GO:0060444)2.40486453
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.39654145
82amino acid import (GO:0043090)2.39507320
83pinocytosis (GO:0006907)2.38479336
84positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38291358
85synaptic vesicle maturation (GO:0016188)2.37776262
86mitotic G1 DNA damage checkpoint (GO:0031571)2.37428421
87vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36935584
88activation of MAPKKK activity (GO:0000185)2.36629516
89regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35817171
90glutamine family amino acid biosynthetic process (GO:0009084)2.35148167
91mannose metabolic process (GO:0006013)2.34623184
92hexose biosynthetic process (GO:0019319)2.34074881
93dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.33636636
94mitotic nuclear envelope reassembly (GO:0007084)2.32989742
95nuclear envelope reassembly (GO:0031468)2.32989742
96glycolytic process (GO:0006096)2.32961297
97positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.32546432
98positive regulation of receptor recycling (GO:0001921)2.32071102
99regulation of NFAT protein import into nucleus (GO:0051532)2.31104761
100peptidyl-proline hydroxylation (GO:0019511)2.30956545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.01859287
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79927121
3LXR_22292898_ChIP-Seq_THP-1_Human2.74783261
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58445203
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48965630
6ZNF263_19887448_ChIP-Seq_K562_Human2.42487371
7RACK7_27058665_Chip-Seq_MCF-7_Human2.39886820
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32426075
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.26845668
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19335482
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17421001
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14645561
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.14552118
14MYC_22102868_ChIP-Seq_BL_Human2.09399086
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.06939395
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06704680
17VDR_21846776_ChIP-Seq_THP-1_Human2.06424984
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06397283
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01109867
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98345241
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88839657
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86439751
23KDM2B_26808549_Chip-Seq_K562_Human1.81862445
24CLOCK_20551151_ChIP-Seq_293T_Human1.76989324
25KDM2B_26808549_Chip-Seq_DND41_Human1.73851095
26TCF7_22412390_ChIP-Seq_EML_Mouse1.73516971
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.73498363
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.66168248
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62376493
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62182328
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59540644
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59512473
33EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59324002
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59071939
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57306935
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56607536
37P68_20966046_ChIP-Seq_HELA_Human1.54374381
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52663225
39SMC4_20622854_ChIP-Seq_HELA_Human1.48620297
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48304988
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47356821
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46346205
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.41216989
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41012961
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40593826
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40444100
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40073051
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39682817
49CREB1_26743006_Chip-Seq_LNCaP_Human1.39474744
50E2F7_22180533_ChIP-Seq_HELA_Human1.37634794
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37255109
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37018146
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34365958
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34099498
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.33978149
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.33887565
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31365614
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30798900
59ATF3_27146783_Chip-Seq_COLON_Human1.29320158
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.29149221
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28817606
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28651670
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26843694
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26684043
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25182303
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.24300658
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22360037
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21706899
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21321654
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20164547
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17214792
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.17176867
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.16653365
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14811831
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14364397
76SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14288599
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13230642
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13189695
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12169611
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10456398
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10082012
82TP53_22127205_ChIP-Seq_IMR90_Human1.09185357
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09171412
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08780986
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.08650189
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.07103288
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.05450450
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05418944
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05013033
90CTCF_27219007_Chip-Seq_Bcells_Human1.04601845
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.03004838
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00315375
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00067968
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99891693
95NCOR1_26117541_ChIP-Seq_K562_Human0.99566269
96XRN2_22483619_ChIP-Seq_HELA_Human0.98227530
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98186421
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95523747
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94391396
100MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94095887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.49617104
2MP0010234_abnormal_vibrissa_follicle3.47820660
3MP0005451_abnormal_body_composition3.15010833
4MP0008438_abnormal_cutaneous_collagen2.81705611
5MP0005058_abnormal_lysosome_morphology2.75279865
6MP0001849_ear_inflammation2.74186685
7MP0004858_abnormal_nervous_system2.67407527
8MP0003566_abnormal_cell_adhesion2.61687856
9MP0002877_abnormal_melanocyte_morpholog2.50797905
10MP0004233_abnormal_muscle_weight2.45506205
11MP0004859_abnormal_synaptic_plasticity2.41606997
12MP0000751_myopathy2.40614610
13MP0002796_impaired_skin_barrier2.12933572
14MP0003329_amyloid_beta_deposits2.10099605
15MP0005076_abnormal_cell_differentiation2.09844848
16MP0000537_abnormal_urethra_morphology2.04403576
17MP0005409_darkened_coat_color2.04113342
18MP0004185_abnormal_adipocyte_glucose2.02556349
19MP0001348_abnormal_lacrimal_gland2.00386332
20MP0008260_abnormal_autophagy1.97861581
21MP0005623_abnormal_meninges_morphology1.94258806
22MP0009780_abnormal_chondrocyte_physiolo1.86862455
23MP0010030_abnormal_orbit_morphology1.73632889
24MP0009840_abnormal_foam_cell1.69438705
25MP0000747_muscle_weakness1.69244462
26MP0003191_abnormal_cellular_cholesterol1.68575844
27MP0005257_abnormal_intraocular_pressure1.67665499
28MP0002089_abnormal_postnatal_growth/wei1.65339505
29MP0003123_paternal_imprinting1.64066155
30MP0003453_abnormal_keratinocyte_physiol1.62233965
31MP0005501_abnormal_skin_physiology1.59436896
32MP0000678_abnormal_parathyroid_gland1.57821349
33MP0004270_analgesia1.50578054
34MP0004272_abnormal_basement_membrane1.49303560
35MP0004264_abnormal_extraembryonic_tissu1.49119238
36MP0000579_abnormal_nail_morphology1.49113548
37MP0000733_abnormal_muscle_development1.48772108
38MP0009672_abnormal_birth_weight1.45755674
39MP0000003_abnormal_adipose_tissue1.44260903
40MP0001346_abnormal_lacrimal_gland1.41146507
41MP0003091_abnormal_cell_migration1.41064893
42MP0002249_abnormal_larynx_morphology1.40891973
43MP0000759_abnormal_skeletal_muscle1.34196408
44MP0004087_abnormal_muscle_fiber1.32204966
45MP0002060_abnormal_skin_morphology1.30989074
46MP0003172_abnormal_lysosome_physiology1.27345581
47MP0005666_abnormal_adipose_tissue1.18696184
48MP0000750_abnormal_muscle_regeneration1.17838079
49MP0001730_embryonic_growth_arrest1.15516926
50MP0005375_adipose_tissue_phenotype1.12926634
51MP0010352_gastrointestinal_tract_polyps1.11369678
52MP0003634_abnormal_glial_cell1.11298821
53MP0003879_abnormal_hair_cell1.08564384
54MP0010630_abnormal_cardiac_muscle1.08073263
55MP0000467_abnormal_esophagus_morphology1.06652024
56MP0001958_emphysema1.06213280
57MP0000858_altered_metastatic_potential1.03175693
58MP0003075_altered_response_to1.02997465
59MP0000462_abnormal_digestive_system1.02141667
60MP0002896_abnormal_bone_mineralization1.02064700
61MP0003279_aneurysm1.00931990
62MP0009278_abnormal_bone_marrow1.00503954
63MP0005023_abnormal_wound_healing0.98505963
64MP0000749_muscle_degeneration0.98488006
65MP0000534_abnormal_ureter_morphology0.97566085
66MP0009053_abnormal_anal_canal0.96799254
67MP0000762_abnormal_tongue_morphology0.94412780
68MP0003941_abnormal_skin_development0.93069486
69MP0002098_abnormal_vibrissa_morphology0.92002500
70MP0000566_synostosis0.91752246
71MP0005621_abnormal_cell_physiology0.90263179
72MP0005330_cardiomyopathy0.88774424
73MP0000681_abnormal_thyroid_gland0.87891871
74MP0002269_muscular_atrophy0.87261055
75MP0008569_lethality_at_weaning0.85590963
76MP0002080_prenatal_lethality0.83173477
77MP0008874_decreased_physiological_sensi0.81205396
78MP0000604_amyloidosis0.78921497
79MP0003115_abnormal_respiratory_system0.78633555
80MP0009384_cardiac_valve_regurgitation0.78595153
81MP0003942_abnormal_urinary_system0.78216750
82MP0006138_congestive_heart_failure0.77574735
83MP0005165_increased_susceptibility_to0.75234612
84MP0005275_abnormal_skin_tensile0.73295026
85MP0010771_integument_phenotype0.73151246
86MP0009379_abnormal_foot_pigmentation0.73117636
87MP0000350_abnormal_cell_proliferation0.72624930
88MP0000377_abnormal_hair_follicle0.71627325
89MP0001216_abnormal_epidermal_layer0.71432413
90MP0004947_skin_inflammation0.70783664
91MP0004782_abnormal_surfactant_physiolog0.69511086
92MP0003300_gastrointestinal_ulcer0.69149396
93MP0009931_abnormal_skin_appearance0.68312755
94MP0004510_myositis0.68215668
95MP0001661_extended_life_span0.67877579
96MP0003111_abnormal_nucleus_morphology0.66626052
97MP0000627_abnormal_mammary_gland0.65910170
98MP0000767_abnormal_smooth_muscle0.65066680
99MP0000920_abnormal_myelination0.63994112
100MP0005508_abnormal_skeleton_morphology0.62361891

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.95214101
2Distal lower limb muscle weakness (HP:0009053)3.49831458
3Premature rupture of membranes (HP:0001788)3.43622296
4Protrusio acetabuli (HP:0003179)3.30336140
5Insomnia (HP:0100785)3.12607850
6Distal lower limb amyotrophy (HP:0008944)3.07431131
7Upper limb amyotrophy (HP:0009129)3.04697376
8Distal upper limb amyotrophy (HP:0007149)3.04697376
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.02096968
10Achilles tendon contracture (HP:0001771)3.01798433
11Vertebral compression fractures (HP:0002953)2.92501421
12Increased connective tissue (HP:0009025)2.86827444
13Abnormality of the Achilles tendon (HP:0005109)2.71621228
14Obstructive sleep apnea (HP:0002870)2.69025659
15Myopathic facies (HP:0002058)2.56994571
16Cerebral aneurysm (HP:0004944)2.55427227
17Lower limb amyotrophy (HP:0007210)2.54054633
18Shallow orbits (HP:0000586)2.52904185
19Hand muscle atrophy (HP:0009130)2.48168151
20Ulnar bowing (HP:0003031)2.45636653
21Spinal rigidity (HP:0003306)2.42416252
22Mildly elevated creatine phosphokinase (HP:0008180)2.41227532
23Increased variability in muscle fiber diameter (HP:0003557)2.40884387
24Broad face (HP:0000283)2.37747954
25Abnormal gallbladder physiology (HP:0012438)2.35322967
26Cholecystitis (HP:0001082)2.35322967
27Abnormality of skeletal muscle fiber size (HP:0012084)2.33616245
28Cerebral inclusion bodies (HP:0100314)2.31326284
29Flat acetabular roof (HP:0003180)2.30355832
30Stridor (HP:0010307)2.28732727
31Asymmetry of the thorax (HP:0001555)2.27272551
32Exercise-induced myalgia (HP:0003738)2.26799882
33J-shaped sella turcica (HP:0002680)2.20901804
34Type 1 muscle fiber predominance (HP:0003803)2.19044724
35Hyperparathyroidism (HP:0000843)2.16881775
36Supranuclear gaze palsy (HP:0000605)2.15817707
37Fragile skin (HP:0001030)2.12572110
38Cervical subluxation (HP:0003308)2.11258182
39Overriding aorta (HP:0002623)2.10938912
40Long palpebral fissure (HP:0000637)2.10465470
41Difficulty climbing stairs (HP:0003551)2.09324866
42Back pain (HP:0003418)2.06022268
43Neurofibrillary tangles (HP:0002185)2.02173472
44Thin bony cortex (HP:0002753)2.00791042
45Dysmetric saccades (HP:0000641)1.99537561
46Generalized amyotrophy (HP:0003700)1.99213444
47Short nail (HP:0001799)1.98795235
48Turricephaly (HP:0000262)1.95643439
49Elfin facies (HP:0004428)1.94378940
50Advanced eruption of teeth (HP:0006288)1.94213894
51Spinal cord compression (HP:0002176)1.94204943
52Abnormality of the distal phalanges of the toes (HP:0010182)1.93795356
53Bladder diverticulum (HP:0000015)1.93383628
54Renal duplication (HP:0000075)1.93139007
55Foot dorsiflexor weakness (HP:0009027)1.92504559
56Mitral regurgitation (HP:0001653)1.92362065
57Trismus (HP:0000211)1.89488373
58Pointed chin (HP:0000307)1.89396873
59Ankle contracture (HP:0006466)1.88543838
60Reticulocytosis (HP:0001923)1.87236327
61Hyporeflexia of lower limbs (HP:0002600)1.85740152
62Progressive muscle weakness (HP:0003323)1.83034219
63Blue sclerae (HP:0000592)1.81957970
64Neuronal loss in central nervous system (HP:0002529)1.81954660
65Ankle clonus (HP:0011448)1.81728033
66Osteolytic defects of the hand bones (HP:0009699)1.80899883
67Osteolytic defects of the phalanges of the hand (HP:0009771)1.80899883
68Disproportionate tall stature (HP:0001519)1.79792953
69Ragged-red muscle fibers (HP:0003200)1.79747656
70Biconcave vertebral bodies (HP:0004586)1.77271206
71Ankyloglossia (HP:0010296)1.76566426
72Elbow flexion contracture (HP:0002987)1.75063789
73Distal sensory impairment (HP:0002936)1.71428130
74Wormian bones (HP:0002645)1.71375095
75Bulbar palsy (HP:0001283)1.70679910
76Arnold-Chiari malformation (HP:0002308)1.69134640
77Patellar dislocation (HP:0002999)1.68361709
78Broad distal phalanx of finger (HP:0009836)1.67490755
79Round ear (HP:0100830)1.66932010
80Insidious onset (HP:0003587)1.66870993
81Termporal pattern (HP:0011008)1.66870993
82Congenital glaucoma (HP:0001087)1.66240964
83Annular pancreas (HP:0001734)1.66159085
84Abnormality of oral frenula (HP:0000190)1.65733238
85Abnormality of the foot musculature (HP:0001436)1.65630408
86Hammertoe (HP:0001765)1.62715112
87Depression (HP:0000716)1.61765535
88Axonal loss (HP:0003447)1.61613828
89Hypercalcemia (HP:0003072)1.61566242
90Hypercortisolism (HP:0001578)1.61416473
91Selective tooth agenesis (HP:0001592)1.60863353
92Abnormality of dentin (HP:0010299)1.60265230
93Deep venous thrombosis (HP:0002625)1.58923841
94Atrophic scars (HP:0001075)1.58848165
95Nuclear cataract (HP:0100018)1.57403094
96Polygenic inheritance (HP:0010982)1.56017965
97Precocious puberty (HP:0000826)1.55941751
98Abnormality of the thoracic spine (HP:0100711)1.53942450
99Asymmetric septal hypertrophy (HP:0001670)1.53611278
100Natal tooth (HP:0000695)1.53172213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.24300486
2SMG13.55268845
3EEF2K2.98528924
4PRPF4B2.81225577
5ICK2.71652474
6SIK12.64818485
7RIPK12.52212872
8EPHA22.39543466
9TTN2.37387872
10IRAK32.19716284
11TESK12.08452792
12NME22.07609109
13ERN12.06958805
14PKN21.95151941
15ARAF1.85551614
16PRKD31.85144811
17LATS21.83355279
18PDGFRA1.59344171
19FGFR41.59092194
20SCYL21.58800038
21PAK41.52270490
22NTRK11.50391809
23KSR21.38482437
24TESK21.37805154
25CDK121.33074218
26PTK21.26967119
27TAOK21.25727875
28MST1R1.23722998
29LIMK11.22813626
30MAP3K91.19927289
31RPS6KB21.16077589
32PAK61.07920599
33LMTK21.07856238
34MAPKAPK31.07053210
35PTK61.04906678
36MAP3K110.99868670
37MAP3K130.98320348
38BRAF0.96406705
39PDPK10.94886388
40MTOR0.94346084
41MAP3K100.94295620
42CAMKK10.84680411
43RPS6KA20.84153778
44MAP2K30.83039082
45MET0.77780358
46BMX0.76712984
47PRKD20.72427528
48MAP3K10.72246040
49ILK0.71817796
50MARK20.71233141
51MAP2K20.70807407
52LRRK20.69835428
53MAP3K30.68943857
54DAPK10.67309881
55MAP3K80.65132825
56CDC42BPA0.62981602
57PAK20.62844998
58PRKG20.62638054
59CDK150.61853259
60BRSK10.61203534
61TYRO30.60886002
62CDK11A0.60610126
63CAMK2G0.60508533
64RET0.58956400
65PIM20.58849721
66CDK70.58106222
67DMPK0.57861181
68EPHB10.57420832
69MAPK110.56775711
70CDK180.56237990
71STK380.55751982
72VRK20.53797357
73ALK0.51530690
74DAPK30.51506861
75EPHA40.51144499
76AKT20.51033660
77PHKG20.50118295
78PHKG10.50118295
79CDK140.49407156
80IRAK20.48290948
81MAP3K60.46878490
82MAPK120.46097403
83NEK60.45516763
84CAMK2B0.45339556
85PDK10.43690235
86RPS6KC10.43554358
87RPS6KL10.43554358
88UHMK10.40617035
89AURKA0.39712741
90DDR20.38273107
91MOS0.37540383
92ROCK20.37060935
93PAK10.37032468
94TAOK10.36695233
95MAP3K20.36310994
96MAP2K10.35197416
97RAF10.34018011
98CAMK1D0.34005078
99CDK60.33924477
100MUSK0.32404569

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46551776
2Pentose phosphate pathway_Homo sapiens_hsa000302.12127786
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07577961
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04135650
5Central carbon metabolism in cancer_Homo sapiens_hsa052301.97316241
6Biosynthesis of amino acids_Homo sapiens_hsa012301.91268105
7Other glycan degradation_Homo sapiens_hsa005111.81955721
8Prion diseases_Homo sapiens_hsa050201.78901482
9Fructose and mannose metabolism_Homo sapiens_hsa000511.72818799
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70713721
11Chronic myeloid leukemia_Homo sapiens_hsa052201.69403260
12VEGF signaling pathway_Homo sapiens_hsa043701.65383518
13Bladder cancer_Homo sapiens_hsa052191.63717893
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.60440934
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59050463
16Glioma_Homo sapiens_hsa052141.57086307
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56059675
18Thyroid cancer_Homo sapiens_hsa052161.54539832
19Non-small cell lung cancer_Homo sapiens_hsa052231.53786042
20Synaptic vesicle cycle_Homo sapiens_hsa047211.52250673
21Endometrial cancer_Homo sapiens_hsa052131.45766308
22Vitamin B6 metabolism_Homo sapiens_hsa007501.44809950
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37977212
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37900631
25Carbon metabolism_Homo sapiens_hsa012001.36927509
26Long-term potentiation_Homo sapiens_hsa047201.36069889
27Vibrio cholerae infection_Homo sapiens_hsa051101.35731412
28Insulin signaling pathway_Homo sapiens_hsa049101.33223595
29Galactose metabolism_Homo sapiens_hsa000521.28453364
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.27238124
31ErbB signaling pathway_Homo sapiens_hsa040121.25584258
32Acute myeloid leukemia_Homo sapiens_hsa052211.25534263
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18247395
34Estrogen signaling pathway_Homo sapiens_hsa049151.18188995
35Notch signaling pathway_Homo sapiens_hsa043301.16381839
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15892703
37Pancreatic cancer_Homo sapiens_hsa052121.14938265
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.13219305
39Focal adhesion_Homo sapiens_hsa045101.11785261
40GnRH signaling pathway_Homo sapiens_hsa049121.10316863
41Arginine biosynthesis_Homo sapiens_hsa002201.10084396
42AMPK signaling pathway_Homo sapiens_hsa041521.07688594
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03390880
44Proteoglycans in cancer_Homo sapiens_hsa052051.03086692
45Renal cell carcinoma_Homo sapiens_hsa052111.02438151
46mTOR signaling pathway_Homo sapiens_hsa041500.98582502
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95712412
48Dilated cardiomyopathy_Homo sapiens_hsa054140.95247501
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94641957
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93151761
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90160621
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90086380
53Sulfur relay system_Homo sapiens_hsa041220.89491846
54Endocytosis_Homo sapiens_hsa041440.88489565
55Phenylalanine metabolism_Homo sapiens_hsa003600.88217895
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86840064
57Glucagon signaling pathway_Homo sapiens_hsa049220.86144504
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85720174
59Adherens junction_Homo sapiens_hsa045200.82446884
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82276520
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.82266579
62Melanogenesis_Homo sapiens_hsa049160.82109776
63Arginine and proline metabolism_Homo sapiens_hsa003300.82048343
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81532881
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81188070
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81105179
67Amoebiasis_Homo sapiens_hsa051460.79417365
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79246028
69Inositol phosphate metabolism_Homo sapiens_hsa005620.76066521
70ECM-receptor interaction_Homo sapiens_hsa045120.75537512
71Tight junction_Homo sapiens_hsa045300.75187099
72Choline metabolism in cancer_Homo sapiens_hsa052310.74813652
73Small cell lung cancer_Homo sapiens_hsa052220.74795640
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74645551
75Lysosome_Homo sapiens_hsa041420.73921724
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.73440125
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.72984378
78Gap junction_Homo sapiens_hsa045400.71753764
79N-Glycan biosynthesis_Homo sapiens_hsa005100.71246892
80Gastric acid secretion_Homo sapiens_hsa049710.69108042
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66928177
82HIF-1 signaling pathway_Homo sapiens_hsa040660.65577826
83Thyroid hormone synthesis_Homo sapiens_hsa049180.62030819
84MicroRNAs in cancer_Homo sapiens_hsa052060.61076869
85Hepatitis C_Homo sapiens_hsa051600.61026231
86Prostate cancer_Homo sapiens_hsa052150.60979276
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60860545
88Shigellosis_Homo sapiens_hsa051310.58673966
89Colorectal cancer_Homo sapiens_hsa052100.57599258
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57034225
91Insulin resistance_Homo sapiens_hsa049310.53901718
92Hippo signaling pathway_Homo sapiens_hsa043900.52679505
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.51982272
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51856369
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50398249
96Prolactin signaling pathway_Homo sapiens_hsa049170.49890656
97Bile secretion_Homo sapiens_hsa049760.49819772
98Apoptosis_Homo sapiens_hsa042100.49620784
99Rap1 signaling pathway_Homo sapiens_hsa040150.49148192
100B cell receptor signaling pathway_Homo sapiens_hsa046620.48045046

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