PTPDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.29476228
2acrosome reaction (GO:0007340)7.01431590
3sperm motility (GO:0030317)6.70567599
4fusion of sperm to egg plasma membrane (GO:0007342)6.69242882
5axon ensheathment in central nervous system (GO:0032291)6.35111956
6central nervous system myelination (GO:0022010)6.35111956
7axonemal dynein complex assembly (GO:0070286)6.17231995
8epithelial cilium movement (GO:0003351)5.73513237
9acrosome assembly (GO:0001675)5.65267301
10piRNA metabolic process (GO:0034587)5.57453563
11multicellular organism reproduction (GO:0032504)5.42679377
12negative regulation of inclusion body assembly (GO:0090084)5.33349556
13cilium movement (GO:0003341)5.27385215
14plasma membrane fusion (GO:0045026)5.17986033
15sperm-egg recognition (GO:0035036)5.10938631
16regulation of cilium movement (GO:0003352)4.99815238
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.88240058
18spermatid development (GO:0007286)4.86645300
19motile cilium assembly (GO:0044458)4.81187099
20male meiosis (GO:0007140)4.71806620
21cell wall macromolecule metabolic process (GO:0044036)4.63897934
22cell wall macromolecule catabolic process (GO:0016998)4.63897934
23binding of sperm to zona pellucida (GO:0007339)4.56257416
24cell-cell recognition (GO:0009988)4.52780426
25reproduction (GO:0000003)4.46715551
26sperm capacitation (GO:0048240)4.43378200
27axon ensheathment (GO:0008366)4.33643834
28ensheathment of neurons (GO:0007272)4.33643834
29synaptonemal complex organization (GO:0070193)4.29937446
30myelination (GO:0042552)4.29279718
31calcium ion-dependent exocytosis (GO:0017156)4.16053401
32microtubule severing (GO:0051013)4.10743622
33single fertilization (GO:0007338)4.03764656
34protein polyglutamylation (GO:0018095)4.01407005
35regulation of centriole replication (GO:0046599)3.98459585
36regulation of synapse structural plasticity (GO:0051823)3.88121023
37synaptonemal complex assembly (GO:0007130)3.85078764
38ventricular system development (GO:0021591)3.83781578
39regulation of microtubule-based movement (GO:0060632)3.81767468
40DNA methylation involved in gamete generation (GO:0043046)3.71429416
41fertilization (GO:0009566)3.65167205
42protein localization to cilium (GO:0061512)3.62706628
43regulation of inclusion body assembly (GO:0090083)3.57551462
44fatty acid elongation (GO:0030497)3.53997223
45nuclear pore complex assembly (GO:0051292)3.45861856
46spermatogenesis (GO:0007283)3.39609554
47male gamete generation (GO:0048232)3.37703575
48long-chain fatty acid biosynthetic process (GO:0042759)3.35623723
49response to pheromone (GO:0019236)3.27670062
50eye photoreceptor cell differentiation (GO:0001754)3.19631205
51photoreceptor cell differentiation (GO:0046530)3.19631205
52male meiosis I (GO:0007141)3.17899236
53negative regulation of neurotransmitter secretion (GO:0046929)3.15598658
54gamete generation (GO:0007276)3.13210333
55negative regulation of neurotransmitter transport (GO:0051589)3.08429849
56pyrimidine nucleobase catabolic process (GO:0006208)3.05727864
57cell recognition (GO:0008037)3.04313536
58neuronal ion channel clustering (GO:0045161)3.03910213
59intraciliary transport (GO:0042073)3.02827384
60negative regulation of organelle assembly (GO:1902116)3.01504892
61oligodendrocyte differentiation (GO:0048709)3.00020662
62neuron cell-cell adhesion (GO:0007158)2.99430611
63neuronal action potential propagation (GO:0019227)2.98529078
64axoneme assembly (GO:0035082)2.96449592
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.95652152
66establishment of mitochondrion localization (GO:0051654)2.95645228
67myelin maintenance (GO:0043217)2.94944265
68regulation of centrosome duplication (GO:0010824)2.93229244
69asymmetric protein localization (GO:0008105)2.91886923
70nuclear pore organization (GO:0006999)2.89937767
71response to methylmercury (GO:0051597)2.89725433
72presynaptic membrane assembly (GO:0097105)2.85658107
73neurotransmitter-gated ion channel clustering (GO:0072578)2.85581377
74cellular process involved in reproduction in multicellular organism (GO:0022412)2.83958509
75presynaptic membrane organization (GO:0097090)2.83112307
76germ cell development (GO:0007281)2.82089151
77apical protein localization (GO:0045176)2.80983361
78organic cation transport (GO:0015695)2.78451660
79left/right pattern formation (GO:0060972)2.77845074
80mitotic sister chromatid cohesion (GO:0007064)2.77266597
81protein hydroxylation (GO:0018126)2.77136970
82vocalization behavior (GO:0071625)2.76692805
83transmission of nerve impulse (GO:0019226)2.67827526
84* cilium morphogenesis (GO:0060271)2.67505199
85pore complex assembly (GO:0046931)2.65566230
86histone H3-K9 demethylation (GO:0033169)2.65524719
87microtubule-based movement (GO:0007018)2.65507217
88microtubule polymerization or depolymerization (GO:0031109)2.64158306
89regulation of centrosome cycle (GO:0046605)2.63493183
90central nervous system projection neuron axonogenesis (GO:0021952)2.62369671
91sister chromatid segregation (GO:0000819)2.62161455
92spermatid nucleus differentiation (GO:0007289)2.61617167
93regulation of collateral sprouting (GO:0048670)2.60073727
94synaptic vesicle maturation (GO:0016188)2.59783801
95L-amino acid import (GO:0043092)2.59276914
96astrocyte development (GO:0014002)2.58102439
97myelination in peripheral nervous system (GO:0022011)2.56490077
98peripheral nervous system axon ensheathment (GO:0032292)2.56490077
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55493962
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55103488
101axon extension (GO:0048675)2.55103152
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53073166
103membrane assembly (GO:0071709)2.52690001
104adult walking behavior (GO:0007628)2.52658461
105calcium ion import (GO:0070509)2.50795809
106postsynaptic membrane organization (GO:0001941)2.50326607
107regulation of axon extension involved in axon guidance (GO:0048841)2.49758311
108microtubule depolymerization (GO:0007019)2.49524217
109peptidyl-proline hydroxylation (GO:0019511)2.48681036
110mitotic chromosome condensation (GO:0007076)2.48441268
111neuron recognition (GO:0008038)2.48009496
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47699191
113regulation of mitotic spindle organization (GO:0060236)2.47532857
114membrane depolarization during action potential (GO:0086010)2.44227056
115multicellular organismal reproductive process (GO:0048609)2.42765716
116chromosome condensation (GO:0030261)2.41969642
117dendrite morphogenesis (GO:0048813)2.40530158
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.39895167
119regulation of cell communication by electrical coupling (GO:0010649)2.38782272
120regulation of axon guidance (GO:1902667)2.38305812
121axonal fasciculation (GO:0007413)2.36630440
122cellular component assembly involved in morphogenesis (GO:0010927)2.36086357
123nucleobase catabolic process (GO:0046113)2.35401340
124negative regulation of protein localization to cell surface (GO:2000009)2.35189775
125negative regulation of fatty acid biosynthetic process (GO:0045717)2.34532123
126central nervous system neuron axonogenesis (GO:0021955)2.34134798
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33591276
128neuron projection extension (GO:1990138)2.33513791
129dendritic spine morphogenesis (GO:0060997)2.33247660
130cilium organization (GO:0044782)2.32746146
131positive regulation of dendritic spine morphogenesis (GO:0061003)2.32446798
132cilium assembly (GO:0042384)2.30374579
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.30355646
134retinal cone cell development (GO:0046549)2.30310145
135mating behavior (GO:0007617)2.29744343
136DNA packaging (GO:0006323)2.29394036
137mitotic sister chromatid segregation (GO:0000070)2.29037268
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28968555
139negative regulation of synaptic transmission, GABAergic (GO:0032229)2.26552744
140regulation of NFAT protein import into nucleus (GO:0051532)2.25934818
141synaptic vesicle docking involved in exocytosis (GO:0016081)2.24788086
142COPII vesicle coating (GO:0048208)2.23473041
143myoblast fusion (GO:0007520)2.22501894
144centrosome duplication (GO:0051298)2.22282923
145protein K6-linked ubiquitination (GO:0085020)2.21273035
146regulation of DNA endoreduplication (GO:0032875)2.20006533
147regulation of Rac protein signal transduction (GO:0035020)2.19717672
148DNA unwinding involved in DNA replication (GO:0006268)2.16878540
149glutamate secretion (GO:0014047)2.15943205
150ganglion development (GO:0061548)2.08984571
151spinal cord development (GO:0021510)2.08263127
152protein localization to synapse (GO:0035418)2.08214402
153sister chromatid cohesion (GO:0007062)2.07475205
154establishment of protein localization to Golgi (GO:0072600)2.06816117
155negative regulation of dendrite morphogenesis (GO:0050774)2.03747720
156anatomical structure arrangement (GO:0048532)2.03600496
157clathrin coat assembly (GO:0048268)2.03409113
158mitotic cytokinesis (GO:0000281)2.01114443
159regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.00657847
160musculoskeletal movement (GO:0050881)1.98775666
161multicellular organismal movement (GO:0050879)1.98775666
162establishment of spindle orientation (GO:0051294)1.97731335
163coronary vasculature morphogenesis (GO:0060977)1.97206648
164inner ear receptor stereocilium organization (GO:0060122)1.94725550
165detection of calcium ion (GO:0005513)1.94447998
166regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.94278216
167NLS-bearing protein import into nucleus (GO:0006607)1.93979995
168cerebral cortex neuron differentiation (GO:0021895)1.93828150
169regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.93751304
170protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)1.93433645
171inositol metabolic process (GO:0006020)1.93419749
172glomerular visceral epithelial cell development (GO:0072015)1.93330846
173cytoplasmic mRNA processing body assembly (GO:0033962)1.91847864
174paraxial mesoderm development (GO:0048339)1.91822995
175positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.91569047
176vesicle transport along microtubule (GO:0047496)1.91051308
177sodium ion export (GO:0071436)1.90108305
178layer formation in cerebral cortex (GO:0021819)1.89530686
179regulation of dendritic spine morphogenesis (GO:0061001)1.89343762
180olfactory bulb development (GO:0021772)1.89084252
181negative chemotaxis (GO:0050919)1.89064219
182synapse assembly (GO:0007416)1.88603051
183ephrin receptor signaling pathway (GO:0048013)1.88576565
184developmental cell growth (GO:0048588)1.88233720
185vesicle coating (GO:0006901)1.88188579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59422803
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.59414756
3E2F7_22180533_ChIP-Seq_HELA_Human3.06363442
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90891262
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82333516
6GBX2_23144817_ChIP-Seq_PC3_Human2.75490578
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72298035
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.54190614
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.19114089
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07954318
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99777924
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96941798
13AR_21909140_ChIP-Seq_LNCAP_Human1.91202278
14TAF15_26573619_Chip-Seq_HEK293_Human1.88212195
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87401456
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87358631
17VDR_22108803_ChIP-Seq_LS180_Human1.85551972
18REST_21632747_ChIP-Seq_MESCs_Mouse1.85032279
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84249023
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80654405
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.78324611
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76742078
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75947416
24DROSHA_22980978_ChIP-Seq_HELA_Human1.73206108
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72486649
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.71700600
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70217842
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66244488
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61533445
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61533445
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.61433531
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60553112
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58087261
34* RNF2_27304074_Chip-Seq_ESCs_Mouse1.58015406
35ZNF274_21170338_ChIP-Seq_K562_Hela1.56944628
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52442195
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51058969
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.46519518
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46258477
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46151089
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45846857
42ER_23166858_ChIP-Seq_MCF-7_Human1.43797732
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43475378
44EWS_26573619_Chip-Seq_HEK293_Human1.42232442
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.41716487
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41131746
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40767877
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40698999
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39930386
50TP53_18474530_ChIP-ChIP_U2OS_Human1.39398922
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38376728
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36023732
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35792628
54* SMAD4_21799915_ChIP-Seq_A2780_Human1.34949585
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34615616
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34613276
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34570169
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34570169
59TP53_16413492_ChIP-PET_HCT116_Human1.34428604
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.33879018
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.33799147
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33251544
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33109837
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32185253
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32025868
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28238976
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27886401
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26033767
69AR_25329375_ChIP-Seq_VCAP_Human1.25655353
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23132346
71RNF2_27304074_Chip-Seq_NSC_Mouse1.23125999
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22320981
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.22169590
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21852864
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21718899
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21337719
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21080782
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.21014408
79* STAT3_23295773_ChIP-Seq_U87_Human1.20243345
80TCF4_23295773_ChIP-Seq_U87_Human1.20063405
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19497887
82* CJUN_26792858_Chip-Seq_BT549_Human1.18722124
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18117401
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17754611
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16768955
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16768955
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16374651
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16264207
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.15114944
90KDM2B_26808549_Chip-Seq_REH_Human1.14539983
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13168251
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13131878
93P300_19829295_ChIP-Seq_ESCs_Human1.12787804
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.12492128
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11639799
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11567967
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11423246
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10977819
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.10535801
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10499674
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10177169
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09888504
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09296960
104FUS_26573619_Chip-Seq_HEK293_Human1.09184258
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.08309293
106BRD4_25478319_ChIP-Seq_HGPS_Human1.07793784
107GF1B_26923725_Chip-Seq_HPCs_Mouse1.07631872
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06917311
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.06578843
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06253965
111* AR_19668381_ChIP-Seq_PC3_Human1.06113123
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.05684733
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.05378419
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03869616
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.03432050
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03280404
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02726162
118RUNX2_22187159_ChIP-Seq_PCA_Human1.01996054
119* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01592835
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.01204644
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01132568
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00887473
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.00272345
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.00147616
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99388149
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98863193
127CBP_20019798_ChIP-Seq_JUKART_Human0.98863193
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.98586681
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98275378
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98071547
131TBL1_22424771_ChIP-Seq_293T_Human0.98060118
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97869372
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.97408249
134* JUN_21703547_ChIP-Seq_K562_Human0.97238738
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95937478
136ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94711931
137TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94503041
138TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94463083
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94176264
140IGF1R_20145208_ChIP-Seq_DFB_Human0.93953949
141PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93566436
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92999129
143AHR_22903824_ChIP-Seq_MCF-7_Human0.92292856
144SOX9_26525672_Chip-Seq_HEART_Mouse0.92226795
145P53_22387025_ChIP-Seq_ESCs_Mouse0.91929312
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91775877
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91013837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.54320829
2MP0004270_analgesia3.22799489
3MP0000920_abnormal_myelination3.10978814
4MP0003880_abnormal_central_pattern3.10021629
5MP0004859_abnormal_synaptic_plasticity2.96141648
6MP0003698_abnormal_male_reproductive2.93411421
7MP0008877_abnormal_DNA_methylation2.40859943
8MP0009046_muscle_twitch2.38076690
9MP0001984_abnormal_olfaction2.37634449
10MP0003705_abnormal_hypodermis_morpholog2.34707992
11MP0001929_abnormal_gametogenesis2.33577848
12MP0003635_abnormal_synaptic_transmissio2.28578822
13MP0002272_abnormal_nervous_system2.26049543
14MP0001486_abnormal_startle_reflex2.18890009
15MP0005623_abnormal_meninges_morphology2.12052446
16MP0008057_abnormal_DNA_replication2.07121682
17MP0002734_abnormal_mechanical_nocicepti2.04475372
18MP0002064_seizures1.99630722
19MP0003329_amyloid_beta_deposits1.94174627
20MP0000778_abnormal_nervous_system1.92943865
21MP0005423_abnormal_somatic_nervous1.90327522
22MP0009745_abnormal_behavioral_response1.83448416
23MP0003634_abnormal_glial_cell1.78308463
24MP0004742_abnormal_vestibular_system1.77849924
25MP0004885_abnormal_endolymph1.76755341
26MP0002063_abnormal_learning/memory/cond1.75849138
27MP0001968_abnormal_touch/_nociception1.75633044
28MP0001529_abnormal_vocalization1.75272684
29MP0004272_abnormal_basement_membrane1.74605889
30MP0002572_abnormal_emotion/affect_behav1.68633932
31MP0003950_abnormal_plasma_membrane1.66074295
32MP0003890_abnormal_embryonic-extraembry1.57928368
33MP0002161_abnormal_fertility/fecundity1.55437186
34MP0002653_abnormal_ependyma_morphology1.52697918
35MP0001905_abnormal_dopamine_level1.51491477
36MP0002210_abnormal_sex_determination1.50675166
37MP0002067_abnormal_sensory_capabilities1.47988700
38MP0003690_abnormal_glial_cell1.46665018
39MP0000955_abnormal_spinal_cord1.44991971
40MP0002269_muscular_atrophy1.41418169
41MP0001485_abnormal_pinna_reflex1.40531221
42MP0001440_abnormal_grooming_behavior1.39333775
43MP0002229_neurodegeneration1.38567661
44MP0002009_preneoplasia1.38404677
45MP0002882_abnormal_neuron_morphology1.36146391
46MP0002733_abnormal_thermal_nociception1.34863900
47MP0010094_abnormal_chromosome_stability1.33440488
48MP0003937_abnormal_limbs/digits/tail_de1.31791821
49MP0002736_abnormal_nociception_after1.30664209
50MP0001970_abnormal_pain_threshold1.30595590
51MP0006276_abnormal_autonomic_nervous1.28601081
52MP0004142_abnormal_muscle_tone1.28450003
53MP0001145_abnormal_male_reproductive1.28007461
54MP0003385_abnormal_body_wall1.26368439
55MP0008569_lethality_at_weaning1.25965483
56MP0005171_absent_coat_pigmentation1.25891162
57MP0010352_gastrointestinal_tract_polyps1.22136527
58MP0001299_abnormal_eye_distance/1.21828722
59MP0004134_abnormal_chest_morphology1.20781912
60MP0005551_abnormal_eye_electrophysiolog1.20620638
61MP0002184_abnormal_innervation1.19995937
62MP0004084_abnormal_cardiac_muscle1.19222144
63MP0003941_abnormal_skin_development1.18526007
64MP0001879_abnormal_lymphatic_vessel1.18368001
65MP0002735_abnormal_chemical_nociception1.18209456
66MP0002877_abnormal_melanocyte_morpholog1.17881835
67MP0002066_abnormal_motor_capabilities/c1.17529338
68MP0005187_abnormal_penis_morphology1.17145677
69MP0004043_abnormal_pH_regulation1.16718937
70MP0000749_muscle_degeneration1.15577120
71MP0003632_abnormal_nervous_system1.14509365
72MP0005409_darkened_coat_color1.14169850
73MP0004145_abnormal_muscle_electrophysio1.13991958
74MP0002557_abnormal_social/conspecific_i1.13215754
75MP0005645_abnormal_hypothalamus_physiol1.12700359
76MP0004811_abnormal_neuron_physiology1.11975928
77MP0000653_abnormal_sex_gland1.11861532
78MP0003631_nervous_system_phenotype1.11359552
79MP0003633_abnormal_nervous_system1.10277800
80MP0002152_abnormal_brain_morphology1.09279766
81MP0004924_abnormal_behavior1.07376429
82MP0005386_behavior/neurological_phenoty1.07376429
83MP0002822_catalepsy1.05372788
84MP0000427_abnormal_hair_cycle1.05346173
85MP0002752_abnormal_somatic_nervous1.05262439
86MP0000013_abnormal_adipose_tissue1.03228722
87MP0002638_abnormal_pupillary_reflex1.02492595
88MP0002160_abnormal_reproductive_system1.02077872
89MP0000569_abnormal_digit_pigmentation1.01885260
90MP0003935_abnormal_craniofacial_develop1.01483778
91MP0008932_abnormal_embryonic_tissue0.98639557
92MP0003115_abnormal_respiratory_system0.98218286
93MP0000751_myopathy0.97964172
94MP0000462_abnormal_digestive_system0.97531299
95MP0003787_abnormal_imprinting0.96975990
96MP0005248_abnormal_Harderian_gland0.95739523
97MP0010307_abnormal_tumor_latency0.95488330
98MP0003755_abnormal_palate_morphology0.94850171
99MP0001963_abnormal_hearing_physiology0.94838087
100MP0003136_yellow_coat_color0.94417691
101MP0004197_abnormal_fetal_growth/weight/0.93895746
102MP0000733_abnormal_muscle_development0.92382507
103MP0005646_abnormal_pituitary_gland0.90278523
104MP0001188_hyperpigmentation0.90054725
105MP0006072_abnormal_retinal_apoptosis0.89288216
106MP0003111_abnormal_nucleus_morphology0.87433398
107MP0001501_abnormal_sleep_pattern0.87150859
108MP0003077_abnormal_cell_cycle0.87106357
109MP0009780_abnormal_chondrocyte_physiolo0.87020381
110MP0000566_synostosis0.86830378
111MP0004215_abnormal_myocardial_fiber0.86165510
112MP0001661_extended_life_span0.84413947
113MP0009703_decreased_birth_body0.83339739
114MP0000003_abnormal_adipose_tissue0.83327182
115MP0002697_abnormal_eye_size0.83214043
116MP0004147_increased_porphyrin_level0.82160272
117MP0004087_abnormal_muscle_fiber0.81896730
118MP0003122_maternal_imprinting0.81885882
119MP0002084_abnormal_developmental_patter0.80724882
120MP0003861_abnormal_nervous_system0.80552841
121MP0000759_abnormal_skeletal_muscle0.80395017
122MP0003566_abnormal_cell_adhesion0.79191574
123MP0000747_muscle_weakness0.79078114
124MP0000631_abnormal_neuroendocrine_gland0.78788540
125MP0010030_abnormal_orbit_morphology0.78173126
126MP0004085_abnormal_heartbeat0.77895913
127MP0000647_abnormal_sebaceous_gland0.77490869
128MP0003121_genomic_imprinting0.77302882
129MP0002102_abnormal_ear_morphology0.75705261
130MP0005253_abnormal_eye_physiology0.73822755
131MP0002081_perinatal_lethality0.72882354
132MP0003137_abnormal_impulse_conducting0.72740799
133MP0003567_abnormal_fetal_cardiomyocyte0.72716388
134MP0005380_embryogenesis_phenotype0.71882635
135MP0001672_abnormal_embryogenesis/_devel0.71882635
136MP0009250_abnormal_appendicular_skeleto0.71828649
137MP0000604_amyloidosis0.71711161
138MP0003942_abnormal_urinary_system0.71393557
139MP0002233_abnormal_nose_morphology0.70712224
140MP0003984_embryonic_growth_retardation0.70072827
141MP0002114_abnormal_axial_skeleton0.69609543
142MP0001177_atelectasis0.69414392
143MP0002088_abnormal_embryonic_growth/wei0.69213881
144MP0005195_abnormal_posterior_eye0.67739067
145MP0001502_abnormal_circadian_rhythm0.66310462
146MP0004233_abnormal_muscle_weight0.66148406
147MP0005503_abnormal_tendon_morphology0.64936676
148MP0002108_abnormal_muscle_morphology0.64031063
149MP0004858_abnormal_nervous_system0.63952586
150MP0000534_abnormal_ureter_morphology0.63840896
151MP0002938_white_spotting0.63767183
152MP0008438_abnormal_cutaneous_collagen0.63597733
153MP0005377_hearing/vestibular/ear_phenot0.61304155

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.52561152
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.09300567
3Absent/shortened dynein arms (HP:0200106)8.09300567
4Abnormal respiratory motile cilium physiology (HP:0012261)6.31863878
5Abnormal respiratory motile cilium morphology (HP:0005938)5.60577306
6Abnormal respiratory epithelium morphology (HP:0012253)5.60577306
7Abnormal ciliary motility (HP:0012262)5.22679877
8Rhinitis (HP:0012384)5.00248538
9Neurofibrillary tangles (HP:0002185)4.28830079
10Chronic bronchitis (HP:0004469)4.09172012
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.00488082
12Degeneration of the lateral corticospinal tracts (HP:0002314)4.00488082
13Infertility (HP:0000789)3.80418583
14Insidious onset (HP:0003587)3.77099981
15Termporal pattern (HP:0011008)3.77099981
16Peripheral hypomyelination (HP:0007182)3.73533886
17Cortical dysplasia (HP:0002539)3.43918299
18Cerebral inclusion bodies (HP:0100314)3.37512829
19Nephronophthisis (HP:0000090)3.35022857
20Abnormality of the corticospinal tract (HP:0002492)3.26952050
21Supranuclear gaze palsy (HP:0000605)3.07122368
22Drooling (HP:0002307)3.07086985
23Sensory axonal neuropathy (HP:0003390)3.00176177
24Onion bulb formation (HP:0003383)2.98873130
25Retinal dysplasia (HP:0007973)2.89822001
26Myokymia (HP:0002411)2.89603739
27Segmental peripheral demyelination/remyelination (HP:0003481)2.83656191
28Ulnar claw (HP:0001178)2.82696621
29Action tremor (HP:0002345)2.76239090
30Spastic gait (HP:0002064)2.75013238
31Excessive salivation (HP:0003781)2.67711585
32Decreased motor nerve conduction velocity (HP:0003431)2.62117678
33Abnormality of the renal medulla (HP:0100957)2.55490703
34Ankle clonus (HP:0011448)2.53725020
35Medial flaring of the eyebrow (HP:0010747)2.48803167
36Polydipsia (HP:0001959)2.40428256
37Abnormal drinking behavior (HP:0030082)2.40428256
38Bronchiectasis (HP:0002110)2.40083414
39Abnormality of midbrain morphology (HP:0002418)2.32361624
40Molar tooth sign on MRI (HP:0002419)2.32361624
41Male infertility (HP:0003251)2.29639498
42Exercise-induced muscle cramps (HP:0003710)2.25390528
43Focal motor seizures (HP:0011153)2.24609734
44Dysmetria (HP:0001310)2.24429798
45Nasal polyposis (HP:0100582)2.22291538
46Papillary thyroid carcinoma (HP:0002895)2.21736119
47Spastic tetraparesis (HP:0001285)2.19550185
48Intention tremor (HP:0002080)2.13221324
49Lower limb muscle weakness (HP:0007340)2.11499588
50Bell-shaped thorax (HP:0001591)2.07014982
51Impaired proprioception (HP:0010831)2.05201126
52Scanning speech (HP:0002168)2.04838771
53Hammertoe (HP:0001765)2.04528553
54Focal seizures (HP:0007359)2.03504646
55Abnormality of the ischium (HP:0003174)2.02142184
56Volvulus (HP:0002580)2.01541142
57Steppage gait (HP:0003376)2.00687833
58Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.00675920
59Genital tract atresia (HP:0001827)2.00593033
60Vaginal atresia (HP:0000148)2.00060436
61Atonic seizures (HP:0010819)1.99641262
62Megalencephaly (HP:0001355)1.98726363
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98718711
64Progressive cerebellar ataxia (HP:0002073)1.98466501
65Abnormality of the astrocytes (HP:0100707)1.95862019
66Astrocytoma (HP:0009592)1.95862019
67Exotropia (HP:0000577)1.95686511
68Gaze-evoked nystagmus (HP:0000640)1.95418514
69Gait imbalance (HP:0002141)1.95195818
70Increased circulating renin level (HP:0000848)1.95151966
71Horizontal nystagmus (HP:0000666)1.92215886
72Abnormality of dentin (HP:0010299)1.91613579
73Tubulointerstitial nephritis (HP:0001970)1.89917222
74Foot dorsiflexor weakness (HP:0009027)1.89669965
75Tubular atrophy (HP:0000092)1.89062449
76Epileptiform EEG discharges (HP:0011182)1.87323080
77Open mouth (HP:0000194)1.86023263
78Hepatoblastoma (HP:0002884)1.85615946
79Hypomagnesemia (HP:0002917)1.83873065
80Narrow palate (HP:0000189)1.82615384
81Abnormal auditory evoked potentials (HP:0006958)1.81697633
82Epileptic encephalopathy (HP:0200134)1.81096271
83Amyotrophic lateral sclerosis (HP:0007354)1.80588437
84Relative macrocephaly (HP:0004482)1.80257902
85Coronal craniosynostosis (HP:0004440)1.80125071
86Bronchitis (HP:0012387)1.79623326
87Upper limb muscle weakness (HP:0003484)1.78830185
88Rhizomelia (HP:0008905)1.78448148
89Urinary urgency (HP:0000012)1.77960343
90EEG with generalized epileptiform discharges (HP:0011198)1.77695724
91Stage 5 chronic kidney disease (HP:0003774)1.74948049
92Congenital primary aphakia (HP:0007707)1.74091984
93Aplasia involving bones of the upper limbs (HP:0009823)1.73216699
94Aplasia of the phalanges of the hand (HP:0009802)1.73216699
95Aplasia involving bones of the extremities (HP:0009825)1.73216699
96Abnormality of the lower motor neuron (HP:0002366)1.72998278
97Hypsarrhythmia (HP:0002521)1.72317477
98Postnatal microcephaly (HP:0005484)1.72312916
99Widely spaced teeth (HP:0000687)1.72079755
100Hypoplastic labia majora (HP:0000059)1.71837654
101Tubulointerstitial abnormality (HP:0001969)1.70946842
102Pulmonic stenosis (HP:0001642)1.70075838
103Hemiparesis (HP:0001269)1.70058875
104Distal sensory impairment (HP:0002936)1.69472945
105Shawl scrotum (HP:0000049)1.69403230
106Midline defect of the nose (HP:0004122)1.68513685
107Clumsiness (HP:0002312)1.67934580
108Thickened helices (HP:0000391)1.67502075
109Abnormality of the foot musculature (HP:0001436)1.67335678
110Pheochromocytoma (HP:0002666)1.66953178
111Alacrima (HP:0000522)1.66159957
112Sandal gap (HP:0001852)1.66057161
113Clonus (HP:0002169)1.65844817
114Polyuria (HP:0000103)1.65394313
115High anterior hairline (HP:0009890)1.64788972
116Labial hypoplasia (HP:0000066)1.63870213
117Spastic tetraplegia (HP:0002510)1.63098893
118Increased nuchal translucency (HP:0010880)1.63003975
119Aplasia/Hypoplasia of the lens (HP:0008063)1.61943123
120Abnormality of the left ventricular outflow tract (HP:0011103)1.61259920
121Subaortic stenosis (HP:0001682)1.61259920
122Bundle branch block (HP:0011710)1.60684862
123Impaired vibration sensation in the lower limbs (HP:0002166)1.60375702
124Microglossia (HP:0000171)1.59760541
125Increased number of teeth (HP:0011069)1.59685447
126Neuronal loss in central nervous system (HP:0002529)1.59566356
127Taurodontia (HP:0000679)1.57620593
128Abnormality of permanent molar morphology (HP:0011071)1.57620593
129Abnormality of the dental root (HP:0006486)1.57620593
130Urinary bladder sphincter dysfunction (HP:0002839)1.57352606
131Nephrogenic diabetes insipidus (HP:0009806)1.56720147
132Postaxial hand polydactyly (HP:0001162)1.56664318
133Recurrent otitis media (HP:0000403)1.56472334
134Failure to thrive in infancy (HP:0001531)1.55663967
135Abnormal urine output (HP:0012590)1.55518126
136Hyperventilation (HP:0002883)1.55067065
137Abnormality of the nasal mucosa (HP:0000433)1.54995665
138Hand muscle atrophy (HP:0009130)1.54994821
139Overlapping toe (HP:0001845)1.54393808
140Febrile seizures (HP:0002373)1.54024218
141Abnormality of the labia majora (HP:0012881)1.53506736
142Hypoplastic female external genitalia (HP:0012815)1.53085344
143Intellectual disability, moderate (HP:0002342)1.52999323
144Atrophic scars (HP:0001075)1.52519695
145Absent eyebrow (HP:0002223)1.50213807
146Lower limb amyotrophy (HP:0007210)1.49985714
147Overgrowth (HP:0001548)1.48978989
148Paraplegia (HP:0010550)1.48087313
149Spastic paraplegia (HP:0001258)1.47690955
150Long foot (HP:0001833)1.46822763
151Abnormality of chromosome segregation (HP:0002916)1.46575321
152Abnormality of the parathyroid morphology (HP:0011766)1.45597579
153Impaired social interactions (HP:0000735)1.45583834
154Abnormal social behavior (HP:0012433)1.45583834
155Gastroesophageal reflux (HP:0002020)1.45582633
156Broad-based gait (HP:0002136)1.45137840
157Osteomalacia (HP:0002749)1.44978990
158Hypoplasia of the corpus callosum (HP:0002079)1.42463471
159Cerebellar dysplasia (HP:0007033)1.42462717
160Glioma (HP:0009733)1.40030374
161Cutaneous finger syndactyly (HP:0010554)1.39556648
162Chromsome breakage (HP:0040012)1.39422752
163Rimmed vacuoles (HP:0003805)1.37282000
164Hyporeflexia of lower limbs (HP:0002600)1.36598079
165Generalized tonic-clonic seizures (HP:0002069)1.34847234
166Heterotopia (HP:0002282)1.34219357
167Small hand (HP:0200055)1.34086037
168Obsessive-compulsive behavior (HP:0000722)1.33800333
169Abnormality of the labia minora (HP:0012880)1.33654642
170Arterial tortuosity (HP:0005116)1.33516597
171Pterygium (HP:0001059)1.32215162
172Autoamputation (HP:0001218)1.31635042
173Hypoplastic ischia (HP:0003175)1.31619718
174Breast hypoplasia (HP:0003187)1.31460540
175Chromosomal breakage induced by crosslinking agents (HP:0003221)1.31314880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.97881834
2PDK33.84537701
3PDK43.84537701
4PRKD33.62283343
5ICK3.33002365
6WNK43.12162106
7PNCK2.95011372
8OXSR12.94487020
9AKT32.75614948
10TESK12.47544297
11PDK22.43045317
12WNK12.24165299
13PLK42.06006400
14PTK2B1.93919035
15LATS21.90731932
16YES11.75027789
17EPHA41.73664578
18WEE11.71240755
19PAK61.70559061
20NTRK31.64812470
21MARK11.54673936
22MAPKAPK51.53665218
23MAPK151.52645913
24EPHB21.51128182
25MST1R1.50994119
26NTRK11.48701307
27OBSCN1.47589945
28FRK1.42494866
29MAP3K121.41652832
30LATS11.41178354
31TYRO31.40650668
32EPHB11.39378918
33CDK191.38405405
34UHMK11.37300658
35MAP3K41.36010790
36NTRK21.34454537
37BCR1.33867170
38FGFR21.33104229
39BUB11.33059301
40TTK1.32822975
41PKN11.30622612
42NEK11.30141116
43BRD41.24551963
44SGK21.24005208
45TNIK1.23435606
46IRAK21.20102359
47CAMK1G1.18148422
48PDGFRA1.16250648
49MET1.15668035
50MARK21.14454294
51MAP3K91.13168108
52CAMK1D1.07824283
53SGK31.04134143
54CAMK2B1.02488622
55SCYL21.02282190
56STK381.01192952
57SGK2231.00695803
58SGK4941.00695803
59CASK0.99841659
60LIMK10.99777758
61PAK30.99769150
62ERBB30.96501823
63EEF2K0.95591868
64CSNK1G20.95485656
65PKN20.93319338
66NEK60.93279231
67TRIM280.89985447
68PHKG10.87960786
69PHKG20.87960786
70CSNK1A1L0.87948342
71CDK50.86381725
72CAMK2D0.86323274
73PTK20.86245294
74CSNK1G30.85200446
75ERBB40.84950379
76CAMK2A0.81966806
77KSR20.80412608
78MINK10.79514672
79PRPF4B0.78394214
80ROCK20.78251292
81STK38L0.77962859
82PINK10.77293912
83CHEK20.75153712
84FGR0.74196539
85BMPR20.73819983
86MAP2K70.73763708
87CDK140.73403463
88WNK30.72895645
89TTN0.71717490
90MAPK130.70865111
91PLK30.70258631
92CDK150.69706736
93IRAK10.67943080
94MAP3K100.67041769
95PDPK10.66684037
96PDK10.66556454
97CDK180.65883953
98FGFR10.65275753
99INSRR0.64262665
100CAMK2G0.63770609
101STK110.63110355
102MAP4K20.63069489
103CDC70.62966831
104PRKCG0.60861839
105ATM0.60841061
106KSR10.60099609
107CDK11A0.58948165
108BMPR1B0.58494564
109DYRK1B0.58251513
110ARAF0.58039697
111CCNB10.57635215
112TRPM70.57487140
113GSK3A0.57060424
114CSNK1G10.55582535
115CHEK10.55559342
116MAP3K20.51039968
117DDR20.50830029
118FLT30.50097533
119NEK20.49685950
120PLK10.49664227
121PRKCQ0.49613186
122DMPK0.47512428
123CDK10.46742028
124EIF2AK30.46107059
125MTOR0.44831769
126PRKCH0.44485963
127PRKD10.42315235
128PLK20.40679849
129PRKD20.40250981
130PRKG10.39913006
131BRAF0.39163439
132CLK10.38322747
133DYRK20.36751130
134MAP2K40.36410460
135LMTK20.36308845
136PRKCE0.36170688
137RET0.35953722
138MUSK0.34768951
139PBK0.33767568
140MAPK100.33406830
141CSNK1D0.32905177
142DYRK1A0.30683756
143STK30.30683271
144PDGFRB0.28894517
145PAK20.28373930
146FYN0.27622521
147CDK30.26203656

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.80021641
2Non-homologous end-joining_Homo sapiens_hsa034502.28790158
3Olfactory transduction_Homo sapiens_hsa047402.18987838
4Steroid biosynthesis_Homo sapiens_hsa001002.12962674
5Ether lipid metabolism_Homo sapiens_hsa005652.08020452
6Glutamatergic synapse_Homo sapiens_hsa047241.97831955
7Amphetamine addiction_Homo sapiens_hsa050311.94947097
8Nicotine addiction_Homo sapiens_hsa050331.88533052
9Dorso-ventral axis formation_Homo sapiens_hsa043201.87646332
10Circadian entrainment_Homo sapiens_hsa047131.86310258
11Vitamin B6 metabolism_Homo sapiens_hsa007501.86286876
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79643834
13GABAergic synapse_Homo sapiens_hsa047271.76842987
14Morphine addiction_Homo sapiens_hsa050321.76155517
15Axon guidance_Homo sapiens_hsa043601.72456983
16Synaptic vesicle cycle_Homo sapiens_hsa047211.71542453
17Long-term potentiation_Homo sapiens_hsa047201.70538467
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69037882
19Fatty acid elongation_Homo sapiens_hsa000621.66005775
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64327711
21Fatty acid biosynthesis_Homo sapiens_hsa000611.62656964
22Dopaminergic synapse_Homo sapiens_hsa047281.57004860
23Cocaine addiction_Homo sapiens_hsa050301.54212676
24Insulin secretion_Homo sapiens_hsa049111.52379326
25Taste transduction_Homo sapiens_hsa047421.51211789
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49368771
27Renin secretion_Homo sapiens_hsa049241.48341149
28Adherens junction_Homo sapiens_hsa045201.46370760
29Salivary secretion_Homo sapiens_hsa049701.44245600
30Fanconi anemia pathway_Homo sapiens_hsa034601.43249528
31Linoleic acid metabolism_Homo sapiens_hsa005911.42325528
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41550568
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41104507
34Serotonergic synapse_Homo sapiens_hsa047261.40879120
35Cell cycle_Homo sapiens_hsa041101.36097664
36Gastric acid secretion_Homo sapiens_hsa049711.33955926
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32831798
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25705529
39Circadian rhythm_Homo sapiens_hsa047101.22821259
40Cardiac muscle contraction_Homo sapiens_hsa042601.21482702
41ECM-receptor interaction_Homo sapiens_hsa045121.20422851
42Cholinergic synapse_Homo sapiens_hsa047251.19871337
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18877689
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17892573
45Long-term depression_Homo sapiens_hsa047301.17300564
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17258821
47Hedgehog signaling pathway_Homo sapiens_hsa043401.16097091
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15642123
49MicroRNAs in cancer_Homo sapiens_hsa052061.15170631
50Sphingolipid metabolism_Homo sapiens_hsa006001.14909724
51Collecting duct acid secretion_Homo sapiens_hsa049661.14260348
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10807625
53Hippo signaling pathway_Homo sapiens_hsa043901.10424042
54cAMP signaling pathway_Homo sapiens_hsa040241.09195778
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08750687
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07332962
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07278183
58Pyruvate metabolism_Homo sapiens_hsa006201.07148312
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05765128
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.04618425
61Melanoma_Homo sapiens_hsa052181.03389288
62Calcium signaling pathway_Homo sapiens_hsa040201.02996803
63Propanoate metabolism_Homo sapiens_hsa006401.01863421
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01446035
65Estrogen signaling pathway_Homo sapiens_hsa049151.01221872
66Oocyte meiosis_Homo sapiens_hsa041140.98013418
67Phototransduction_Homo sapiens_hsa047440.97454034
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.97116759
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96635457
70Focal adhesion_Homo sapiens_hsa045100.95267839
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95263862
72RNA transport_Homo sapiens_hsa030130.95071221
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93916193
74Oxytocin signaling pathway_Homo sapiens_hsa049210.93471964
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90208313
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90119903
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.88898805
78Lysine degradation_Homo sapiens_hsa003100.87790949
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87716038
80TGF-beta signaling pathway_Homo sapiens_hsa043500.87478328
81Gap junction_Homo sapiens_hsa045400.87305604
82Glucagon signaling pathway_Homo sapiens_hsa049220.85812192
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85491089
84Protein export_Homo sapiens_hsa030600.85016616
85Sulfur metabolism_Homo sapiens_hsa009200.83990994
86Vibrio cholerae infection_Homo sapiens_hsa051100.83897392
87Endocytosis_Homo sapiens_hsa041440.83053505
88Renal cell carcinoma_Homo sapiens_hsa052110.81418475
89Pancreatic secretion_Homo sapiens_hsa049720.79562345
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79533210
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78539203
92One carbon pool by folate_Homo sapiens_hsa006700.78149856
93ErbB signaling pathway_Homo sapiens_hsa040120.78133150
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77951986
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77651870
96Thyroid hormone synthesis_Homo sapiens_hsa049180.76505136
97mRNA surveillance pathway_Homo sapiens_hsa030150.76495636
98Tight junction_Homo sapiens_hsa045300.76435981
99Small cell lung cancer_Homo sapiens_hsa052220.76312467
100Biosynthesis of amino acids_Homo sapiens_hsa012300.76023198
101Alcoholism_Homo sapiens_hsa050340.74501168
102Endometrial cancer_Homo sapiens_hsa052130.74124720
103Melanogenesis_Homo sapiens_hsa049160.74067411
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.73921471
105AMPK signaling pathway_Homo sapiens_hsa041520.72802611
106Mineral absorption_Homo sapiens_hsa049780.72241517
107Ras signaling pathway_Homo sapiens_hsa040140.71960703
108Basal cell carcinoma_Homo sapiens_hsa052170.71560297
109Colorectal cancer_Homo sapiens_hsa052100.71499722
110Ovarian steroidogenesis_Homo sapiens_hsa049130.71335763
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70983164
112Huntingtons disease_Homo sapiens_hsa050160.70189666
113Proteoglycans in cancer_Homo sapiens_hsa052050.70036157
114Butanoate metabolism_Homo sapiens_hsa006500.69500614
115Prostate cancer_Homo sapiens_hsa052150.69181409
116N-Glycan biosynthesis_Homo sapiens_hsa005100.68235957
117Mismatch repair_Homo sapiens_hsa034300.67612739
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.66221224
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66122176
120Glycerolipid metabolism_Homo sapiens_hsa005610.65158281
121Alzheimers disease_Homo sapiens_hsa050100.65145287
122mTOR signaling pathway_Homo sapiens_hsa041500.64743305
123GnRH signaling pathway_Homo sapiens_hsa049120.64111717
124Insulin signaling pathway_Homo sapiens_hsa049100.63266141
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62461652
126Wnt signaling pathway_Homo sapiens_hsa043100.62215742
127ABC transporters_Homo sapiens_hsa020100.61938664
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61171457
129MAPK signaling pathway_Homo sapiens_hsa040100.58534568
130Chronic myeloid leukemia_Homo sapiens_hsa052200.58298344
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57545274
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57184833
133Oxidative phosphorylation_Homo sapiens_hsa001900.56300453
134Type II diabetes mellitus_Homo sapiens_hsa049300.56180484
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55995954
136Selenocompound metabolism_Homo sapiens_hsa004500.55773639
137FoxO signaling pathway_Homo sapiens_hsa040680.55436634
138Choline metabolism in cancer_Homo sapiens_hsa052310.55371707
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55248094
140DNA replication_Homo sapiens_hsa030300.54174924
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53075348
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52098193
143Fatty acid metabolism_Homo sapiens_hsa012120.51155058
144Inositol phosphate metabolism_Homo sapiens_hsa005620.50619418
145VEGF signaling pathway_Homo sapiens_hsa043700.47534055
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47337137
147Dilated cardiomyopathy_Homo sapiens_hsa054140.46796030
148Basal transcription factors_Homo sapiens_hsa030220.45940150
149Glioma_Homo sapiens_hsa052140.45264545

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