Rank | Gene Set | Z-score |
---|---|---|
1 | ribosomal small subunit biogenesis (GO:0042274) | 6.58631034 |
2 | ribosomal small subunit assembly (GO:0000028) | 5.64156517 |
3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.61211648 |
4 | viral transcription (GO:0019083) | 5.33730035 |
5 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 5.28852297 |
6 | translational termination (GO:0006415) | 5.15013975 |
7 | ribosomal large subunit biogenesis (GO:0042273) | 5.01096576 |
8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.95043853 |
9 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.92084067 |
10 | ATP synthesis coupled proton transport (GO:0015986) | 4.92084067 |
11 | proteasome assembly (GO:0043248) | 4.86308231 |
12 | cotranslational protein targeting to membrane (GO:0006613) | 4.86027825 |
13 | protein targeting to ER (GO:0045047) | 4.84246175 |
14 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.82707369 |
15 | chaperone-mediated protein transport (GO:0072321) | 4.81654302 |
16 | regulation of mitochondrial translation (GO:0070129) | 4.71848442 |
17 | respiratory electron transport chain (GO:0022904) | 4.68328653 |
18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.64293907 |
19 | protein localization to endoplasmic reticulum (GO:0070972) | 4.63741749 |
20 | translational elongation (GO:0006414) | 4.60510232 |
21 | electron transport chain (GO:0022900) | 4.58175587 |
22 | maturation of SSU-rRNA (GO:0030490) | 4.47486922 |
23 | protein maturation by protein folding (GO:0022417) | 4.36220635 |
24 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.34747072 |
25 | viral life cycle (GO:0019058) | 4.11849774 |
26 | translation (GO:0006412) | 4.10791305 |
27 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.09360175 |
28 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.09245860 |
29 | translational initiation (GO:0006413) | 4.07749849 |
30 | protein targeting to mitochondrion (GO:0006626) | 4.01549462 |
31 | cellular protein complex disassembly (GO:0043624) | 3.95416977 |
32 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.94080375 |
33 | protein complex biogenesis (GO:0070271) | 3.88649728 |
34 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.88187180 |
35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.84759778 |
36 | negative regulation of ligase activity (GO:0051352) | 3.84759778 |
37 | cellular component biogenesis (GO:0044085) | 3.82702218 |
38 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.79137125 |
39 | oxidative phosphorylation (GO:0006119) | 3.77270036 |
40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.74234517 |
41 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.72875090 |
42 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.67871313 |
43 | termination of RNA polymerase III transcription (GO:0006386) | 3.66476242 |
44 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.66476242 |
45 | establishment of protein localization to mitochondrion (GO:0072655) | 3.65932497 |
46 | protein localization to mitochondrion (GO:0070585) | 3.62788845 |
47 | rRNA modification (GO:0000154) | 3.62441924 |
48 | pseudouridine synthesis (GO:0001522) | 3.54902101 |
49 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.54216946 |
50 | NADH dehydrogenase complex assembly (GO:0010257) | 3.54216946 |
51 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.54216946 |
52 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.53651426 |
53 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.53263813 |
54 | rRNA processing (GO:0006364) | 3.51351036 |
55 | ncRNA 3-end processing (GO:0043628) | 3.48998359 |
56 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.42989648 |
57 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.42989648 |
58 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.42653839 |
59 | formation of translation preinitiation complex (GO:0001731) | 3.40368060 |
60 | GTP biosynthetic process (GO:0006183) | 3.39536390 |
61 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.39053404 |
62 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.36022774 |
63 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.36022774 |
64 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34300809 |
65 | protein complex disassembly (GO:0043241) | 3.33460561 |
66 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.32343886 |
67 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.32343886 |
68 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.32343886 |
69 | rRNA metabolic process (GO:0016072) | 3.31702285 |
70 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.30196167 |
71 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.29646719 |
72 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.28936051 |
73 | ribosome assembly (GO:0042255) | 3.27139495 |
74 | protein targeting to membrane (GO:0006612) | 3.26876071 |
75 | establishment of integrated proviral latency (GO:0075713) | 3.26506334 |
76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.25463673 |
77 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.25463673 |
78 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.24635711 |
79 | purine nucleotide salvage (GO:0032261) | 3.23902276 |
80 | nucleoside salvage (GO:0043174) | 3.23630619 |
81 | positive regulation of ligase activity (GO:0051351) | 3.21268636 |
82 | macromolecular complex disassembly (GO:0032984) | 3.21221287 |
83 | DNA strand elongation (GO:0022616) | 3.19056685 |
84 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.16764291 |
85 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.16110758 |
86 | deoxyribonucleotide catabolic process (GO:0009264) | 3.15075928 |
87 | respiratory chain complex IV assembly (GO:0008535) | 3.12430178 |
88 | deoxyribose phosphate catabolic process (GO:0046386) | 3.11707781 |
89 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.10523045 |
90 | UTP biosynthetic process (GO:0006228) | 3.09205859 |
91 | cytochrome complex assembly (GO:0017004) | 3.08878835 |
92 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.06818296 |
93 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.06792586 |
94 | mitochondrial transport (GO:0006839) | 3.06010241 |
95 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.05172282 |
96 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.05172282 |
97 | UTP metabolic process (GO:0046051) | 3.05095322 |
98 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.04539579 |
99 | aerobic respiration (GO:0009060) | 3.02438700 |
100 | nucleotide salvage (GO:0043173) | 3.01755521 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.46811098 |
2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.28301471 |
3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.97294586 |
4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.95441087 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.87216682 |
6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.71434010 |
7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.46664054 |
8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.30925012 |
9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.30846413 |
10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.26908600 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.23245427 |
12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.22837741 |
13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.17722903 |
14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.74646544 |
15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.71786428 |
16 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.69806992 |
17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.64609885 |
18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.60242746 |
19 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.50736238 |
20 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.41621956 |
21 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.39434894 |
22 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.38359389 |
23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28373978 |
24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.23344716 |
25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.22432473 |
26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.18571012 |
27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.13469419 |
28 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.10599432 |
29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.09772692 |
30 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.99313401 |
31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.97786014 |
32 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.97006310 |
33 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.93435307 |
34 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.86627933 |
35 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.84015256 |
36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.81658357 |
37 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.81357641 |
38 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.78628785 |
39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.76378442 |
40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.75485852 |
41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.72987054 |
42 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.72827286 |
43 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.72144264 |
44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.71948498 |
45 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.71352590 |
46 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69260257 |
47 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.61657975 |
48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59896852 |
49 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.51548008 |
50 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.50866968 |
51 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.48681780 |
52 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.46855621 |
53 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.46099472 |
54 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.45712164 |
55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.44591588 |
56 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.40525748 |
57 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.35173084 |
58 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34702209 |
59 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.34354590 |
60 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.34271551 |
61 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.30095801 |
62 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.29181909 |
63 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.27802406 |
64 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.25415781 |
65 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.22297504 |
66 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.21959797 |
67 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.21054489 |
68 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.20708929 |
69 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.19537700 |
70 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.18413426 |
71 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.15786069 |
72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.13301932 |
73 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.12584447 |
74 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.12079185 |
75 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.10394417 |
76 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.05731832 |
77 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.05480760 |
78 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.04954894 |
79 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.02636088 |
80 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.02276917 |
81 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.01902748 |
82 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.01052893 |
83 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.00353604 |
84 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.99933747 |
85 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.99836685 |
86 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.99605802 |
87 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99033813 |
88 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.97376413 |
89 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94444972 |
90 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.92919115 |
91 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.91578642 |
92 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91160263 |
93 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.87670120 |
94 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.85880143 |
95 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.84970223 |
96 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.83528493 |
97 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.80646589 |
98 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.80417457 |
99 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.79830295 |
100 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.78596353 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003806_abnormal_nucleotide_metabolis | 5.79465520 |
2 | MP0003186_abnormal_redox_activity | 4.14123958 |
3 | MP0008058_abnormal_DNA_repair | 3.55168562 |
4 | MP0006036_abnormal_mitochondrial_physio | 3.49388482 |
5 | MP0009379_abnormal_foot_pigmentation | 3.36336634 |
6 | MP0003693_abnormal_embryo_hatching | 3.30104624 |
7 | MP0004957_abnormal_blastocyst_morpholog | 3.03014047 |
8 | MP0010094_abnormal_chromosome_stability | 2.95866298 |
9 | MP0003786_premature_aging | 2.55573823 |
10 | MP0006035_abnormal_mitochondrial_morpho | 2.51251247 |
11 | MP0005058_abnormal_lysosome_morphology | 2.42498425 |
12 | MP0009697_abnormal_copulation | 2.33157171 |
13 | MP0008007_abnormal_cellular_replicative | 2.28845251 |
14 | MP0003123_paternal_imprinting | 2.20724143 |
15 | MP0003718_maternal_effect | 2.18247006 |
16 | MP0002837_dystrophic_cardiac_calcinosis | 2.16602424 |
17 | MP0003077_abnormal_cell_cycle | 2.10878496 |
18 | MP0008932_abnormal_embryonic_tissue | 2.07352720 |
19 | MP0003111_abnormal_nucleus_morphology | 2.05555542 |
20 | MP0001727_abnormal_embryo_implantation | 2.04114444 |
21 | MP0001853_heart_inflammation | 1.94169143 |
22 | MP0001881_abnormal_mammary_gland | 1.92851459 |
23 | MP0002877_abnormal_melanocyte_morpholog | 1.84071721 |
24 | MP0002163_abnormal_gland_morphology | 1.78510037 |
25 | MP0005379_endocrine/exocrine_gland_phen | 1.76833576 |
26 | MP0008875_abnormal_xenobiotic_pharmacok | 1.74937287 |
27 | MP0000358_abnormal_cell_content/ | 1.74171452 |
28 | MP0003315_abnormal_perineum_morphology | 1.71272408 |
29 | MP0002160_abnormal_reproductive_system | 1.67775389 |
30 | MP0001764_abnormal_homeostasis | 1.65006615 |
31 | MP0002148_abnormal_hypersensitivity_rea | 1.60701615 |
32 | MP0009333_abnormal_splenocyte_physiolog | 1.56809899 |
33 | MP0005501_abnormal_skin_physiology | 1.44216615 |
34 | MP0001905_abnormal_dopamine_level | 1.41119160 |
35 | MP0000490_abnormal_crypts_of | 1.38791778 |
36 | MP0005646_abnormal_pituitary_gland | 1.34293184 |
37 | MP0005389_reproductive_system_phenotype | 1.31131965 |
38 | MP0004233_abnormal_muscle_weight | 1.26852333 |
39 | MP0005084_abnormal_gallbladder_morpholo | 1.26297109 |
40 | MP0005636_abnormal_mineral_homeostasis | 1.24224984 |
41 | MP0006292_abnormal_olfactory_placode | 1.23270358 |
42 | MP0005319_abnormal_enzyme/_coenzyme | 1.21552699 |
43 | MP0000313_abnormal_cell_death | 1.18734850 |
44 | MP0000343_altered_response_to | 1.18156127 |
45 | MP0002019_abnormal_tumor_incidence | 1.17352331 |
46 | MP0003011_delayed_dark_adaptation | 1.15142351 |
47 | MP0003941_abnormal_skin_development | 1.13423873 |
48 | MP0005165_increased_susceptibility_to | 1.12289291 |
49 | MP0001919_abnormal_reproductive_system | 1.10896192 |
50 | MP0003075_altered_response_to | 1.10501751 |
51 | MP0005408_hypopigmentation | 1.09898155 |
52 | MP0005220_abnormal_exocrine_pancreas | 1.09082579 |
53 | MP0005075_abnormal_melanosome_morpholog | 1.08703845 |
54 | MP0001873_stomach_inflammation | 1.07831383 |
55 | MP0006082_CNS_inflammation | 1.06392978 |
56 | MP0000627_abnormal_mammary_gland | 1.04282924 |
57 | MP0008873_increased_physiological_sensi | 1.04158411 |
58 | MP0003191_abnormal_cellular_cholesterol | 1.03688299 |
59 | MP0005410_abnormal_fertilization | 1.01944762 |
60 | MP0000350_abnormal_cell_proliferation | 0.99622882 |
61 | MP0000372_irregular_coat_pigmentation | 0.97780346 |
62 | MP0000681_abnormal_thyroid_gland | 0.94799648 |
63 | MP0005330_cardiomyopathy | 0.94721603 |
64 | MP0002796_impaired_skin_barrier | 0.92965312 |
65 | MP0005367_renal/urinary_system_phenotyp | 0.92829698 |
66 | MP0000516_abnormal_urinary_system | 0.92829698 |
67 | MP0009785_altered_susceptibility_to | 0.92186075 |
68 | MP0005083_abnormal_biliary_tract | 0.91704770 |
69 | MP0005332_abnormal_amino_acid | 0.90680348 |
70 | MP0004147_increased_porphyrin_level | 0.88642953 |
71 | MP0005397_hematopoietic_system_phenotyp | 0.88083423 |
72 | MP0001545_abnormal_hematopoietic_system | 0.88083423 |
73 | MP0002210_abnormal_sex_determination | 0.87020535 |
74 | MP0006072_abnormal_retinal_apoptosis | 0.84587494 |
75 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.82899915 |
76 | MP0005670_abnormal_white_adipose | 0.81856188 |
77 | MP0008469_abnormal_protein_level | 0.79431052 |
78 | MP0001661_extended_life_span | 0.77965856 |
79 | MP0002095_abnormal_skin_pigmentation | 0.76424240 |
80 | MP0001145_abnormal_male_reproductive | 0.76133684 |
81 | MP0001929_abnormal_gametogenesis | 0.75569290 |
82 | MP0004510_myositis | 0.71815905 |
83 | MP0002277_abnormal_respiratory_mucosa | 0.71485925 |
84 | MP0000653_abnormal_sex_gland | 0.71361178 |
85 | MP0005266_abnormal_metabolism | 0.71059915 |
86 | MP0002693_abnormal_pancreas_physiology | 0.69240717 |
87 | MP0001730_embryonic_growth_arrest | 0.68677933 |
88 | MP0004185_abnormal_adipocyte_glucose | 0.68416724 |
89 | MP0002234_abnormal_pharynx_morphology | 0.68097992 |
90 | MP0002090_abnormal_vision | 0.67920651 |
91 | MP0009643_abnormal_urine_homeostasis | 0.67355695 |
92 | MP0004808_abnormal_hematopoietic_stem | 0.66753762 |
93 | MP0003172_abnormal_lysosome_physiology | 0.66501277 |
94 | MP0003195_calcinosis | 0.65890498 |
95 | MP0001529_abnormal_vocalization | 0.65505099 |
96 | MP0001542_abnormal_bone_strength | 0.63964052 |
97 | MP0009840_abnormal_foam_cell | 0.63215497 |
98 | MP0002080_prenatal_lethality | 0.62822678 |
99 | MP0001944_abnormal_pancreas_morphology | 0.61218585 |
100 | MP0001697_abnormal_embryo_size | 0.59261988 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.64928223 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.51093732 |
3 | Mitochondrial inheritance (HP:0001427) | 5.17019152 |
4 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.97393332 |
5 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.97393332 |
6 | Acute encephalopathy (HP:0006846) | 4.86004749 |
7 | Increased CSF lactate (HP:0002490) | 4.82444661 |
8 | Increased hepatocellular lipid droplets (HP:0006565) | 4.63636710 |
9 | Hepatocellular necrosis (HP:0001404) | 4.59135174 |
10 | Progressive macrocephaly (HP:0004481) | 4.58996560 |
11 | Hepatic necrosis (HP:0002605) | 4.41638495 |
12 | Increased intramyocellular lipid droplets (HP:0012240) | 4.38326549 |
13 | Lipid accumulation in hepatocytes (HP:0006561) | 4.23500773 |
14 | Cerebral edema (HP:0002181) | 4.08645641 |
15 | Renal Fanconi syndrome (HP:0001994) | 4.06690522 |
16 | Increased muscle lipid content (HP:0009058) | 3.84483320 |
17 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.78388108 |
18 | Lactic acidosis (HP:0003128) | 3.67733421 |
19 | Abnormal number of erythroid precursors (HP:0012131) | 3.49857064 |
20 | Increased serum lactate (HP:0002151) | 3.45638423 |
21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.41841867 |
22 | Macrocytic anemia (HP:0001972) | 3.41437427 |
23 | Exercise intolerance (HP:0003546) | 3.36703154 |
24 | 3-Methylglutaconic aciduria (HP:0003535) | 3.34194408 |
25 | Respiratory failure (HP:0002878) | 3.25468969 |
26 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.25226007 |
27 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.20666854 |
28 | Exertional dyspnea (HP:0002875) | 3.18144197 |
29 | Type I transferrin isoform profile (HP:0003642) | 3.15487736 |
30 | Reticulocytopenia (HP:0001896) | 3.09428680 |
31 | Respiratory difficulties (HP:0002880) | 2.80022331 |
32 | Testicular atrophy (HP:0000029) | 2.77372360 |
33 | Microvesicular hepatic steatosis (HP:0001414) | 2.72551784 |
34 | Increased serum pyruvate (HP:0003542) | 2.67128856 |
35 | Progressive muscle weakness (HP:0003323) | 2.62954585 |
36 | Aplastic anemia (HP:0001915) | 2.60321616 |
37 | Lethargy (HP:0001254) | 2.58839613 |
38 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.54905051 |
39 | Abnormality of alanine metabolism (HP:0010916) | 2.54905051 |
40 | Hyperalaninemia (HP:0003348) | 2.54905051 |
41 | Dicarboxylic aciduria (HP:0003215) | 2.52410984 |
42 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.52410984 |
43 | Microretrognathia (HP:0000308) | 2.52163131 |
44 | Leukodystrophy (HP:0002415) | 2.50034664 |
45 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.49449735 |
46 | Multiple enchondromatosis (HP:0005701) | 2.48048937 |
47 | Optic disc pallor (HP:0000543) | 2.42320438 |
48 | Abnormality of the anterior horn cell (HP:0006802) | 2.42315149 |
49 | Degeneration of anterior horn cells (HP:0002398) | 2.42315149 |
50 | Pallor (HP:0000980) | 2.38068154 |
51 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.37200633 |
52 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.37200633 |
53 | Abnormal protein glycosylation (HP:0012346) | 2.37200633 |
54 | Abnormal glycosylation (HP:0012345) | 2.37200633 |
55 | CNS demyelination (HP:0007305) | 2.35778154 |
56 | Abnormality of glycolysis (HP:0004366) | 2.33746979 |
57 | Abnormality of glycolipid metabolism (HP:0010969) | 2.30791886 |
58 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.30791886 |
59 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.30791886 |
60 | Opisthotonus (HP:0002179) | 2.27084931 |
61 | Abnormality of renal resorption (HP:0011038) | 2.27056182 |
62 | Reduced antithrombin III activity (HP:0001976) | 2.27004130 |
63 | Ragged-red muscle fibers (HP:0003200) | 2.25733185 |
64 | Generalized aminoaciduria (HP:0002909) | 2.18326631 |
65 | Emotional lability (HP:0000712) | 2.17262593 |
66 | Hepatosplenomegaly (HP:0001433) | 2.13156795 |
67 | Sparse eyelashes (HP:0000653) | 2.12561797 |
68 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.11140278 |
69 | Pancytopenia (HP:0001876) | 2.10412172 |
70 | Hyperphosphaturia (HP:0003109) | 2.05863497 |
71 | Oral leukoplakia (HP:0002745) | 2.04017641 |
72 | Methylmalonic aciduria (HP:0012120) | 2.00838993 |
73 | Progressive neurologic deterioration (HP:0002344) | 1.98625274 |
74 | Fasciculations (HP:0002380) | 1.95884944 |
75 | Nausea (HP:0002018) | 1.93391189 |
76 | Cleft eyelid (HP:0000625) | 1.93184934 |
77 | Rough bone trabeculation (HP:0100670) | 1.89515013 |
78 | Prolonged neonatal jaundice (HP:0006579) | 1.88648484 |
79 | Abnormality of urine glucose concentration (HP:0011016) | 1.87335442 |
80 | Glycosuria (HP:0003076) | 1.87335442 |
81 | Cerebral hypomyelination (HP:0006808) | 1.86344686 |
82 | Death in infancy (HP:0001522) | 1.85954593 |
83 | Spastic paraparesis (HP:0002313) | 1.82682219 |
84 | Abnormality of methionine metabolism (HP:0010901) | 1.81604226 |
85 | Vacuolated lymphocytes (HP:0001922) | 1.81088422 |
86 | Sensory axonal neuropathy (HP:0003390) | 1.80222390 |
87 | Hypokinesia (HP:0002375) | 1.79850191 |
88 | Congenital, generalized hypertrichosis (HP:0004540) | 1.78237703 |
89 | Hypoglycemic coma (HP:0001325) | 1.77479263 |
90 | Neoplasm of head and neck (HP:0012288) | 1.74721938 |
91 | Esophageal neoplasm (HP:0100751) | 1.74721938 |
92 | Gliosis (HP:0002171) | 1.74155565 |
93 | Abnormality of serum amino acid levels (HP:0003112) | 1.71812997 |
94 | Entropion (HP:0000621) | 1.69861155 |
95 | Progressive microcephaly (HP:0000253) | 1.69818060 |
96 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.69644980 |
97 | Methylmalonic acidemia (HP:0002912) | 1.69582453 |
98 | X-linked dominant inheritance (HP:0001423) | 1.67306424 |
99 | Blindness (HP:0000618) | 1.67126653 |
100 | Concave nail (HP:0001598) | 1.64952928 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NME2 | 5.90061702 |
2 | VRK2 | 3.88563814 |
3 | BCKDK | 3.38181200 |
4 | BUB1 | 3.12196498 |
5 | TESK1 | 3.01464976 |
6 | STK16 | 2.90210314 |
7 | PBK | 2.84393442 |
8 | TESK2 | 2.70800976 |
9 | NEK1 | 2.64744482 |
10 | SCYL2 | 2.54284260 |
11 | EIF2AK1 | 2.50816466 |
12 | LIMK1 | 2.26514382 |
13 | ARAF | 2.19438313 |
14 | PIM2 | 2.16281093 |
15 | CDC7 | 1.99842927 |
16 | ABL2 | 1.97622497 |
17 | PDK2 | 1.97529254 |
18 | MST4 | 1.90193301 |
19 | EIF2AK3 | 1.79000248 |
20 | MAP3K12 | 1.77234874 |
21 | VRK1 | 1.71228259 |
22 | IRAK3 | 1.71036995 |
23 | SRPK1 | 1.61527146 |
24 | TLK1 | 1.60621382 |
25 | KDR | 1.56732743 |
26 | RPS6KB2 | 1.56605335 |
27 | MAPKAPK3 | 1.47030707 |
28 | CDK19 | 1.40138009 |
29 | PLK4 | 1.24734683 |
30 | NME1 | 1.24362553 |
31 | DAPK1 | 1.18694152 |
32 | ILK | 1.09643952 |
33 | CDK8 | 1.02821254 |
34 | PLK1 | 1.01571716 |
35 | EPHA2 | 1.00903528 |
36 | KIT | 1.00740137 |
37 | ZAK | 0.98197653 |
38 | LRRK2 | 0.97751651 |
39 | AURKB | 0.89995221 |
40 | CSNK1G3 | 0.89885466 |
41 | AURKA | 0.89875134 |
42 | PAK4 | 0.89463209 |
43 | DYRK3 | 0.86943407 |
44 | TTK | 0.84036226 |
45 | MAP3K11 | 0.83255803 |
46 | TSSK6 | 0.78714007 |
47 | IKBKB | 0.77613055 |
48 | RPS6KA4 | 0.77282444 |
49 | ATR | 0.71821742 |
50 | MST1R | 0.71366551 |
51 | CSNK2A2 | 0.70123973 |
52 | RPS6KA5 | 0.70005414 |
53 | WEE1 | 0.69827697 |
54 | NUAK1 | 0.68002698 |
55 | PLK3 | 0.66575697 |
56 | CSNK2A1 | 0.66329518 |
57 | FLT3 | 0.63521200 |
58 | CDK7 | 0.61988612 |
59 | CSNK1G1 | 0.60841797 |
60 | CSF1R | 0.59427641 |
61 | DAPK3 | 0.58853855 |
62 | PRKCI | 0.57955377 |
63 | CSNK1G2 | 0.57149831 |
64 | MAPKAPK5 | 0.56549023 |
65 | CCNB1 | 0.55502303 |
66 | TBK1 | 0.55330987 |
67 | EIF2AK2 | 0.53757808 |
68 | CAMK2G | 0.53597731 |
69 | CHEK2 | 0.53295859 |
70 | MUSK | 0.50973242 |
71 | CSNK1A1L | 0.50382785 |
72 | MAP4K2 | 0.47738257 |
73 | BRSK1 | 0.45845502 |
74 | TAOK2 | 0.44132143 |
75 | PAK1 | 0.43159342 |
76 | TEC | 0.42599456 |
77 | BRAF | 0.42147747 |
78 | MAP2K7 | 0.41699772 |
79 | PHKG2 | 0.40660454 |
80 | PHKG1 | 0.40660454 |
81 | ERBB4 | 0.39237263 |
82 | BMPR2 | 0.38682828 |
83 | MYLK | 0.37678543 |
84 | CAMK2D | 0.37484269 |
85 | ATM | 0.33257130 |
86 | AKT2 | 0.33166170 |
87 | MAP3K8 | 0.32310865 |
88 | CSNK1A1 | 0.31798335 |
89 | CHEK1 | 0.29273583 |
90 | TRIM28 | 0.28702612 |
91 | CDK14 | 0.26158402 |
92 | STK10 | 0.25846283 |
93 | GRK1 | 0.25572250 |
94 | STK4 | 0.24723720 |
95 | CDK3 | 0.23577171 |
96 | PASK | 0.23309023 |
97 | PRKCD | 0.21193115 |
98 | CDK11A | 0.20800835 |
99 | CAMK2B | 0.19055745 |
100 | ALK | 0.18771614 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 4.85539172 |
2 | Proteasome_Homo sapiens_hsa03050 | 4.37739516 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.02831530 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.36804868 |
5 | DNA replication_Homo sapiens_hsa03030 | 3.34850176 |
6 | Mismatch repair_Homo sapiens_hsa03430 | 2.79841077 |
7 | RNA polymerase_Homo sapiens_hsa03020 | 2.61938227 |
8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.39432373 |
9 | Homologous recombination_Homo sapiens_hsa03440 | 2.33450226 |
10 | Base excision repair_Homo sapiens_hsa03410 | 2.28802457 |
11 | Protein export_Homo sapiens_hsa03060 | 2.24880218 |
12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.24484060 |
13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.20288059 |
14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.16934386 |
15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.10801948 |
16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.06765456 |
17 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.99166843 |
18 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.78645444 |
19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.77976450 |
20 | Spliceosome_Homo sapiens_hsa03040 | 1.63308039 |
21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.62829677 |
22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.57613409 |
23 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.54540615 |
24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.50575316 |
25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.46040743 |
26 | Sulfur relay system_Homo sapiens_hsa04122 | 1.45845065 |
27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.43066914 |
28 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.38206425 |
29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.37825260 |
30 | Purine metabolism_Homo sapiens_hsa00230 | 1.33000488 |
31 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.32979374 |
32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.28335670 |
33 | RNA transport_Homo sapiens_hsa03013 | 1.22734960 |
34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.21942296 |
35 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.21039145 |
36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.20608879 |
37 | Carbon metabolism_Homo sapiens_hsa01200 | 1.16960154 |
38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.12203723 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.06183059 |
40 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.97491993 |
41 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.96906939 |
42 | Peroxisome_Homo sapiens_hsa04146 | 0.96617613 |
43 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.90427797 |
44 | RNA degradation_Homo sapiens_hsa03018 | 0.88922653 |
45 | Metabolic pathways_Homo sapiens_hsa01100 | 0.86860854 |
46 | Other glycan degradation_Homo sapiens_hsa00511 | 0.83234311 |
47 | Basal transcription factors_Homo sapiens_hsa03022 | 0.82807731 |
48 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.76485952 |
49 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.74348540 |
50 | Asthma_Homo sapiens_hsa05310 | 0.73000147 |
51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.72538643 |
52 | Lysosome_Homo sapiens_hsa04142 | 0.70845231 |
53 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.70754503 |
54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70005770 |
55 | Cell cycle_Homo sapiens_hsa04110 | 0.69284394 |
56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68857193 |
57 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.60978939 |
58 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.60791073 |
59 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.59763189 |
60 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.57329587 |
61 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.57177120 |
62 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.55307404 |
63 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.54585708 |
64 | Galactose metabolism_Homo sapiens_hsa00052 | 0.53508602 |
65 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.53165543 |
66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.52517014 |
67 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.50126405 |
68 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.49511762 |
69 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.46974059 |
70 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.45486479 |
71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44938606 |
72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.44921660 |
73 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44382960 |
74 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.43591008 |
75 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.39382639 |
76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.38501503 |
77 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.37664604 |
78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.36847138 |
79 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.36116093 |
80 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36006751 |
81 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.35583262 |
82 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.34747342 |
83 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.34739840 |
84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.33122585 |
85 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.32395586 |
86 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.28838849 |
87 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.28109541 |
88 | Allograft rejection_Homo sapiens_hsa05330 | 0.26468634 |
89 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.25498671 |
90 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.24480932 |
91 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.24453780 |
92 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.24312509 |
93 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.23730929 |
94 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.22378215 |
95 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.22103302 |
96 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.17414266 |
97 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.13723985 |
98 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.13443783 |
99 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.13392055 |
100 | Legionellosis_Homo sapiens_hsa05134 | 0.13126454 |