PTPN11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.83183755
2nuclear pore organization (GO:0006999)5.03879419
3plasma membrane repair (GO:0001778)4.74660545
4pore complex assembly (GO:0046931)4.25983156
5DNA unwinding involved in DNA replication (GO:0006268)4.12308736
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.01374757
7negative regulation of potassium ion transmembrane transport (GO:1901380)3.90381394
8mitotic sister chromatid cohesion (GO:0007064)3.85913803
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.76441900
10cardiac myofibril assembly (GO:0055003)3.71907469
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.69616969
12mitotic chromosome condensation (GO:0007076)3.68238055
13regulation of RNA export from nucleus (GO:0046831)3.47947984
14cell communication by electrical coupling (GO:0010644)3.44992138
15regulation of mitotic spindle organization (GO:0060236)3.39446451
16sarcomere organization (GO:0045214)3.39049817
17cellular protein complex localization (GO:0034629)3.37225590
18regulation of nucleobase-containing compound transport (GO:0032239)3.36730548
19skin morphogenesis (GO:0043589)3.34678025
20protein localization to endosome (GO:0036010)3.32605870
21paraxial mesoderm development (GO:0048339)3.30816609
22activation of protein kinase A activity (GO:0034199)3.24845095
23stress fiber assembly (GO:0043149)3.23874940
24regulation of translational fidelity (GO:0006450)3.21834685
25cell adhesion mediated by integrin (GO:0033627)3.21763273
26hemidesmosome assembly (GO:0031581)3.19140472
27negative regulation of cell size (GO:0045792)3.17858888
28locomotory exploration behavior (GO:0035641)3.16619302
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.15425831
30sodium ion export (GO:0071436)3.14868885
31cell communication involved in cardiac conduction (GO:0086065)3.14409370
32insulin-like growth factor receptor signaling pathway (GO:0048009)3.13098076
33protein complex localization (GO:0031503)3.11238823
34synaptic vesicle maturation (GO:0016188)3.04530053
35establishment of nucleus localization (GO:0040023)2.99566949
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.99036318
37regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98408105
38myofibril assembly (GO:0030239)2.94245688
39layer formation in cerebral cortex (GO:0021819)2.91008544
40cardiac muscle contraction (GO:0060048)2.90851564
41hippo signaling (GO:0035329)2.85861052
42negative regulation of fatty acid transport (GO:2000192)2.82173208
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81302384
44protein localization to microtubule (GO:0035372)2.80418323
45adherens junction assembly (GO:0034333)2.79912043
46desmosome organization (GO:0002934)2.79546044
47NLS-bearing protein import into nucleus (GO:0006607)2.79220785
48positive regulation of glycogen biosynthetic process (GO:0045725)2.76604691
49sister chromatid segregation (GO:0000819)2.76482852
50potassium ion import (GO:0010107)2.74668037
51carnitine shuttle (GO:0006853)2.74476216
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72953837
53vesicle coating (GO:0006901)2.72070710
54actomyosin structure organization (GO:0031032)2.70613519
55glucocorticoid receptor signaling pathway (GO:0042921)2.70537831
56protein retention in ER lumen (GO:0006621)2.68658987
57regulation of ARF protein signal transduction (GO:0032012)2.66377607
58Golgi transport vesicle coating (GO:0048200)2.66065528
59COPI coating of Golgi vesicle (GO:0048205)2.66065528
60regulation of fatty acid beta-oxidation (GO:0031998)2.64166972
61regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63998853
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63422610
63regulation of synapse structural plasticity (GO:0051823)2.62388387
64cytoskeleton-dependent cytokinesis (GO:0061640)2.60849618
65cerebellar Purkinje cell layer development (GO:0021680)2.60192516
66regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59521330
67positive regulation of fatty acid beta-oxidation (GO:0032000)2.59464255
68protein export from nucleus (GO:0006611)2.59390453
69regulation of NFAT protein import into nucleus (GO:0051532)2.59243361
70regulation of membrane repolarization (GO:0060306)2.59224540
71mitotic sister chromatid segregation (GO:0000070)2.58517827
72regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.58264364
73positive regulation of histone deacetylation (GO:0031065)2.57822717
74notochord development (GO:0030903)2.57554601
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.55454188
76mitotic cytokinesis (GO:0000281)2.55166718
77regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53732144
78regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53309407
79COPII vesicle coating (GO:0048208)2.52379031
80focal adhesion assembly (GO:0048041)2.52342395
81cell-substrate adherens junction assembly (GO:0007045)2.52342395
82peptidyl-lysine dimethylation (GO:0018027)2.52084033
83ventricular cardiac muscle cell action potential (GO:0086005)2.51788070
84relaxation of cardiac muscle (GO:0055119)2.51497084
85fatty acid transmembrane transport (GO:1902001)2.50618008
86activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50117431
87regulation of clathrin-mediated endocytosis (GO:2000369)2.49312230
88histone H2B ubiquitination (GO:0033523)2.48048529
89regulation of fatty acid oxidation (GO:0046320)2.47975873
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47361739
91ribosome assembly (GO:0042255)2.46164201
92protein targeting to plasma membrane (GO:0072661)2.44876146
93activation of Rac GTPase activity (GO:0032863)2.44669513
94cytoplasmic mRNA processing body assembly (GO:0033962)2.43706545
95regulation of tight junction assembly (GO:2000810)2.42704097
96cell-substrate junction assembly (GO:0007044)2.41854186
97regulation of p38MAPK cascade (GO:1900744)2.41377714
98cardiac muscle cell development (GO:0055013)2.40944529
99morphogenesis of an epithelial sheet (GO:0002011)2.40924949
100membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.40912671
101epithelial cell-cell adhesion (GO:0090136)2.40403718
102cellular potassium ion homeostasis (GO:0030007)2.38468077
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.37167166
104regulation of spindle organization (GO:0090224)2.36667103
105growth hormone secretion (GO:0030252)2.36665768
106positive regulation of fatty acid oxidation (GO:0046321)2.33997522
107positive regulation of nuclease activity (GO:0032075)2.32889143
108heart trabecula formation (GO:0060347)2.32487841
109negative regulation of cytosolic calcium ion concentration (GO:0051481)2.32401193
110RNA stabilization (GO:0043489)2.31746949
111mRNA stabilization (GO:0048255)2.31746949
112macroautophagy (GO:0016236)2.30987690
113peptidyl-threonine modification (GO:0018210)2.29844905
114DNA duplex unwinding (GO:0032508)2.29599997
115negative regulation of potassium ion transport (GO:0043267)2.29487746
116negative regulation of dendrite morphogenesis (GO:0050774)2.29398965
117positive regulation of glycogen metabolic process (GO:0070875)2.28876122
118protein localization to chromosome, centromeric region (GO:0071459)2.27731926
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.27678304
120negative regulation of nucleotide catabolic process (GO:0030812)2.27153076
121neuromuscular junction development (GO:0007528)2.26363519
122cardiac cell development (GO:0055006)2.26016322
123protein hydroxylation (GO:0018126)2.25200680
124synaptic vesicle docking involved in exocytosis (GO:0016081)2.25151921
125apoptotic cell clearance (GO:0043277)2.25050098
126regulation of calcium ion transmembrane transporter activity (GO:1901019)2.24275347
127regulation of calcium ion transmembrane transport (GO:1903169)2.24275347
128embryonic retina morphogenesis in camera-type eye (GO:0060059)2.23852630
129hypotonic response (GO:0006971)2.23405799
130negative regulation of DNA repair (GO:0045738)2.23371134
131DNA topological change (GO:0006265)2.22365199
132chromosome condensation (GO:0030261)2.21588587
133neuromuscular process controlling balance (GO:0050885)2.21246347
134membrane repolarization (GO:0086009)2.20685961
135nerve growth factor signaling pathway (GO:0038180)2.20636197
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.20421822
137regulation of sequestering of triglyceride (GO:0010889)2.20157618
138regulation of the force of heart contraction (GO:0002026)2.20074593
139cortical actin cytoskeleton organization (GO:0030866)2.19727647
140muscle filament sliding (GO:0030049)2.19399181
141actin-myosin filament sliding (GO:0033275)2.19399181
142positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.19095467
143establishment of integrated proviral latency (GO:0075713)2.18850272
144regulation of early endosome to late endosome transport (GO:2000641)2.18216972
145cell migration involved in sprouting angiogenesis (GO:0002042)2.18084836
146mitotic metaphase plate congression (GO:0007080)2.17829245
147vesicle transport along microtubule (GO:0047496)2.17647140
148tricarboxylic acid cycle (GO:0006099)2.17266466
149membrane repolarization during action potential (GO:0086011)2.16810520
150regulation of histone H3-K27 methylation (GO:0061085)2.16387139
151regulation of sister chromatid cohesion (GO:0007063)2.15679591
152positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.15322041
153positive regulation of sodium ion transport (GO:0010765)2.15250984
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15092526
155negative regulation of catenin import into nucleus (GO:0035414)2.14719235
156negative regulation of vascular permeability (GO:0043116)2.14219184
157peptidyl-threonine phosphorylation (GO:0018107)2.14096627
158negative regulation of cardiac muscle tissue growth (GO:0055022)2.13242076
159negative regulation of heart growth (GO:0061117)2.13242076
160DNA geometric change (GO:0032392)2.13202077
161mating behavior (GO:0007617)2.12846204
162dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.12495965
163growth hormone receptor signaling pathway (GO:0060396)2.12456133
164spliceosomal tri-snRNP complex assembly (GO:0000244)2.12316315
165neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.12056905
166regulation of transforming growth factor beta2 production (GO:0032909)2.11967612
167regulation of cAMP-dependent protein kinase activity (GO:2000479)2.11247341
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.10130273
169localization within membrane (GO:0051668)2.08519452
170regulation of Rac protein signal transduction (GO:0035020)2.08229134
171regulation of mammary gland epithelial cell proliferation (GO:0033599)2.08167725
172regulation of translational termination (GO:0006449)2.07927506
173cytokinesis (GO:0000910)2.07787165
174negative regulation of anoikis (GO:2000811)2.07640206
175corticosteroid receptor signaling pathway (GO:0031958)2.06312134
176embryonic process involved in female pregnancy (GO:0060136)2.05812799
177bundle of His cell to Purkinje myocyte communication (GO:0086069)2.04847902
178regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.04548915
179positive regulation of protein localization to plasma membrane (GO:1903078)2.04482584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.15145356
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.24255846
3AR_21909140_ChIP-Seq_LNCAP_Human3.44465361
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.08105015
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71573545
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70251037
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.69757825
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33975440
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25475812
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.21973188
11CLOCK_20551151_ChIP-Seq_293T_Human2.21904332
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13116238
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06314811
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.03145180
15PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.99475148
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.97819565
17KDM2B_26808549_Chip-Seq_K562_Human1.91676978
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91039908
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87440547
20ZNF263_19887448_ChIP-Seq_K562_Human1.83464315
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.83175829
22DROSHA_22980978_ChIP-Seq_HELA_Human1.83151988
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.83099697
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.82790436
25* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.82506189
26* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79526072
27KDM2B_26808549_Chip-Seq_DND41_Human1.78503775
28* RARB_27405468_Chip-Seq_BRAIN_Mouse1.77289034
29TBX20_22328084_ChIP-Seq_HEART_Mouse1.74768905
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.74768905
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74003638
32* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73913582
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71349101
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69613605
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67756490
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67756490
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64949184
38EZH2_22144423_ChIP-Seq_EOC_Human1.64610160
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64544387
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61658724
41* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60240776
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58614179
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58092902
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57253161
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57253161
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56478692
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56327326
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55967076
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55898204
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51426723
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51324075
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50098739
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47771817
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46362475
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45518630
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45180918
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.45136066
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.44602109
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.43596699
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43062775
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42633344
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.42333967
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40888346
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39529375
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39401372
66BRD4_25478319_ChIP-Seq_HGPS_Human1.38686364
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.38594285
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37463453
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36932174
70EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36651757
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36140146
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35718403
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35120142
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34962517
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33252254
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.32058015
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31932266
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31897026
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31269852
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31220924
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31037405
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30287559
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30068411
84CHD1_26751641_Chip-Seq_LNCaP_Human1.29984478
85* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29335495
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27990811
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27841891
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27554837
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27002491
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26636222
91RACK7_27058665_Chip-Seq_MCF-7_Human1.26523768
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26224792
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25948503
94* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25271990
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.24739643
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23944113
97* LXR_22292898_ChIP-Seq_THP-1_Human1.23541206
98CREB1_26743006_Chip-Seq_LNCaP_Human1.23387766
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22719321
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21615966
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20423205
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.20053770
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19997917
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19950967
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19721862
106LXR_22158963_ChIP-Seq_LIVER_Mouse1.17970393
107GATA1_19941826_ChIP-Seq_K562_Human1.15998205
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.15659553
109TCF7_22412390_ChIP-Seq_EML_Mouse1.15512065
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.15358541
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13645823
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13453011
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13038969
114MYC_22102868_ChIP-Seq_BL_Human1.11354737
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11290089
116TP53_16413492_ChIP-PET_HCT116_Human1.11014819
117JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10392662
118* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10276018
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10148184
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09974072
121* ATF3_27146783_Chip-Seq_COLON_Human1.09739218
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09001122
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08981826
124NANOG_21062744_ChIP-ChIP_HESCs_Human1.08793694
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08549477
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08448885
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08280674
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07189268
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07144237
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05100555
131RNF2_27304074_Chip-Seq_ESCs_Mouse1.04190389
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04175189
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03816321
134EZH2_27294783_Chip-Seq_ESCs_Mouse1.03779166
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02535723
136* AR_19668381_ChIP-Seq_PC3_Human1.02353756
137AHR_22903824_ChIP-Seq_MCF-7_Human1.02191194
138SOX17_20123909_ChIP-Seq_XEN_Mouse1.01561865
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01381929
140NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01015090
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00846142
142RXR_22108803_ChIP-Seq_LS180_Human0.99528219
143SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97441045
144GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97090209
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.97005603
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96898747
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96845206
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96695502
149UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95320657
150SOX2_21211035_ChIP-Seq_LN229_Gbm0.95046795
151MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94725673
152ZNF274_21170338_ChIP-Seq_K562_Hela0.94466352
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93343817
154POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92719522
155STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92659943
156FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92420718
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.92280881
158RXR_22158963_ChIP-Seq_LIVER_Mouse0.91726386
159YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89256633
160SMAD_19615063_ChIP-ChIP_OVARY_Human0.87268143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.70489255
2MP0003705_abnormal_hypodermis_morpholog3.65314149
3MP0004084_abnormal_cardiac_muscle3.14190642
4MP0000751_myopathy3.11475241
5MP0004859_abnormal_synaptic_plasticity2.77711275
6MP0008438_abnormal_cutaneous_collagen2.72993098
7MP0004130_abnormal_muscle_cell2.59000564
8MP0005623_abnormal_meninges_morphology2.54246121
9MP0009780_abnormal_chondrocyte_physiolo2.52342503
10MP0000013_abnormal_adipose_tissue2.35029863
11MP0004185_abnormal_adipocyte_glucose2.31267274
12MP0004036_abnormal_muscle_relaxation2.28808686
13MP0008057_abnormal_DNA_replication2.24193020
14MP0004215_abnormal_myocardial_fiber2.23368436
15MP0010234_abnormal_vibrissa_follicle2.22297055
16* MP0004087_abnormal_muscle_fiber2.18227010
17MP0005330_cardiomyopathy2.08294848
18MP0005666_abnormal_adipose_tissue2.05084083
19MP0005409_darkened_coat_color2.00203805
20MP0003283_abnormal_digestive_organ1.97273256
21MP0000003_abnormal_adipose_tissue1.95967024
22MP0003941_abnormal_skin_development1.94845170
23MP0005375_adipose_tissue_phenotype1.89167861
24MP0005275_abnormal_skin_tensile1.84665650
25MP0003300_gastrointestinal_ulcer1.82654585
26MP0000747_muscle_weakness1.81709395
27MP0005257_abnormal_intraocular_pressure1.80485760
28MP0002009_preneoplasia1.79399733
29MP0008961_abnormal_basal_metabolism1.78418746
30MP0003646_muscle_fatigue1.77619501
31MP0000749_muscle_degeneration1.77354073
32MP0010630_abnormal_cardiac_muscle1.74840030
33MP0003566_abnormal_cell_adhesion1.73465237
34MP0002972_abnormal_cardiac_muscle1.72765818
35MP0006138_congestive_heart_failure1.66360555
36MP0008775_abnormal_heart_ventricle1.65966525
37MP0005620_abnormal_muscle_contractility1.62658832
38MP0003950_abnormal_plasma_membrane1.60501367
39MP0004145_abnormal_muscle_electrophysio1.60258226
40MP0004272_abnormal_basement_membrane1.58509175
41MP0002269_muscular_atrophy1.57721041
42MP0000750_abnormal_muscle_regeneration1.56672314
43MP0001730_embryonic_growth_arrest1.56085135
44MP0005670_abnormal_white_adipose1.55517555
45MP0000579_abnormal_nail_morphology1.54018567
46MP0004233_abnormal_muscle_weight1.52595401
47MP0002060_abnormal_skin_morphology1.52455431
48* MP0002909_abnormal_adrenal_gland1.50471614
49MP0001544_abnormal_cardiovascular_syste1.46626384
50MP0005385_cardiovascular_system_phenoty1.46626384
51MP0003137_abnormal_impulse_conducting1.44003108
52MP0003045_fibrosis1.43887583
53MP0000733_abnormal_muscle_development1.41371557
54MP0005076_abnormal_cell_differentiation1.38747566
55* MP0003111_abnormal_nucleus_morphology1.38305312
56* MP0004957_abnormal_blastocyst_morpholog1.37789282
57MP0005187_abnormal_penis_morphology1.37709506
58MP0010352_gastrointestinal_tract_polyps1.37164578
59MP0004085_abnormal_heartbeat1.35394593
60* MP0000759_abnormal_skeletal_muscle1.35196742
61MP0009672_abnormal_birth_weight1.34969174
62MP0002106_abnormal_muscle_physiology1.34273926
63MP0004858_abnormal_nervous_system1.34185898
64MP0004484_altered_response_of1.31409430
65MP0003091_abnormal_cell_migration1.31023525
66MP0003279_aneurysm1.30930881
67MP0010094_abnormal_chromosome_stability1.28434630
68MP0001915_intracranial_hemorrhage1.25166404
69MP0001661_extended_life_span1.24679534
70MP0002796_impaired_skin_barrier1.24146976
71MP0003077_abnormal_cell_cycle1.23977493
72* MP0000350_abnormal_cell_proliferation1.21433441
73MP0003635_abnormal_synaptic_transmissio1.20741524
74MP0008932_abnormal_embryonic_tissue1.19834354
75* MP0005380_embryogenesis_phenotype1.19414449
76* MP0001672_abnormal_embryogenesis/_devel1.19414449
77MP0005369_muscle_phenotype1.18675519
78* MP0003984_embryonic_growth_retardation1.17232073
79* MP0002084_abnormal_developmental_patter1.15990105
80MP0009053_abnormal_anal_canal1.15748260
81* MP0002086_abnormal_extraembryonic_tissu1.15165356
82MP0002697_abnormal_eye_size1.15144758
83MP0003329_amyloid_beta_deposits1.13622646
84MP0004270_analgesia1.13462173
85MP0002896_abnormal_bone_mineralization1.12280236
86MP0009384_cardiac_valve_regurgitation1.12050082
87* MP0002088_abnormal_embryonic_growth/wei1.11191862
88MP0001958_emphysema1.11006101
89MP0003453_abnormal_keratinocyte_physiol1.09227436
90* MP0000762_abnormal_tongue_morphology1.09166895
91MP0010678_abnormal_skin_adnexa1.07570060
92MP0005621_abnormal_cell_physiology1.07071428
93MP0005501_abnormal_skin_physiology1.06868144
94* MP0002080_prenatal_lethality1.06711504
95MP0002822_catalepsy1.06064990
96* MP0001299_abnormal_eye_distance/1.05136262
97MP0001697_abnormal_embryo_size1.04359634
98MP0005023_abnormal_wound_healing1.03559270
99MP0010368_abnormal_lymphatic_system1.01645102
100* MP0002085_abnormal_embryonic_tissue1.00690374
101MP0005167_abnormal_blood-brain_barrier1.00688238
102MP0004510_myositis1.00027980
103MP0003868_abnormal_feces_composition0.99298214
104MP0001849_ear_inflammation0.97813455
105* MP0004197_abnormal_fetal_growth/weight/0.96788202
106MP0000537_abnormal_urethra_morphology0.95990434
107MP0010307_abnormal_tumor_latency0.93860030
108MP0009697_abnormal_copulation0.93037741
109MP0002108_abnormal_muscle_morphology0.92474408
110MP0000462_abnormal_digestive_system0.91981600
111MP0003693_abnormal_embryo_hatching0.89020296
112MP0003937_abnormal_limbs/digits/tail_de0.88869470
113MP0000627_abnormal_mammary_gland0.87999721
114MP0000569_abnormal_digit_pigmentation0.87430433
115* MP0000266_abnormal_heart_morphology0.87326496
116MP0008007_abnormal_cellular_replicative0.86480683
117MP0002092_abnormal_eye_morphology0.85981820
118MP0009703_decreased_birth_body0.85825791
119MP0008569_lethality_at_weaning0.84045319
120* MP0003935_abnormal_craniofacial_develop0.83178618
121MP0003942_abnormal_urinary_system0.82581349
122MP0000377_abnormal_hair_follicle0.79693114
123MP0005451_abnormal_body_composition0.79150442
124* MP0000432_abnormal_head_morphology0.78932815
125MP0000467_abnormal_esophagus_morphology0.78801581
126MP0004043_abnormal_pH_regulation0.78524361
127MP0000534_abnormal_ureter_morphology0.78302613
128MP0003385_abnormal_body_wall0.76076043
129* MP0002078_abnormal_glucose_homeostasis0.75776760
130* MP0002128_abnormal_blood_circulation0.74439117
131MP0002063_abnormal_learning/memory/cond0.74122995
132MP0003828_pulmonary_edema0.70375616
133MP0003252_abnormal_bile_duct0.70243570
134* MP0002925_abnormal_cardiovascular_devel0.69722233
135* MP0002971_abnormal_brown_adipose0.68598733
136MP0003303_peritoneal_inflammation0.68106723
137MP0001944_abnormal_pancreas_morphology0.67288046
138MP0003115_abnormal_respiratory_system0.67056030
139MP0005248_abnormal_Harderian_gland0.66626600
140MP0002168_other_aberrant_phenotype0.66370083
141MP0004811_abnormal_neuron_physiology0.65923686
142* MP0000428_abnormal_craniofacial_morphol0.64917728
143MP0002295_abnormal_pulmonary_circulatio0.63553860
144MP0005503_abnormal_tendon_morphology0.63399177
145MP0004885_abnormal_endolymph0.62629403
146MP0001348_abnormal_lacrimal_gland0.60794983
147MP0000767_abnormal_smooth_muscle0.59537405
148MP0001177_atelectasis0.59280023
149MP0003633_abnormal_nervous_system0.58934139
150MP0003122_maternal_imprinting0.57022030
151MP0002090_abnormal_vision0.55862783
152MP0002089_abnormal_postnatal_growth/wei0.55791707
153* MP0002877_abnormal_melanocyte_morpholog0.55310627

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)3.70623393
2Cerebral aneurysm (HP:0004944)3.41594824
3Hyporeflexia of lower limbs (HP:0002600)3.37377609
4Difficulty running (HP:0009046)3.16083304
5Increased connective tissue (HP:0009025)3.12123670
6Arterial tortuosity (HP:0005116)3.04306928
7Exercise-induced muscle cramps (HP:0003710)3.03120258
8Shallow orbits (HP:0000586)3.01848838
9Muscle fiber splitting (HP:0003555)3.00709478
10Vascular tortuosity (HP:0004948)2.90444699
11Protrusio acetabuli (HP:0003179)2.86032225
12Right ventricular cardiomyopathy (HP:0011663)2.82420106
13Exercise-induced myalgia (HP:0003738)2.79322441
14Premature rupture of membranes (HP:0001788)2.78134916
15Atrial fibrillation (HP:0005110)2.77591417
16Asymmetry of the thorax (HP:0001555)2.76616577
17Ventricular fibrillation (HP:0001663)2.73878343
18Ventricular tachycardia (HP:0004756)2.72326562
19Broad metatarsal (HP:0001783)2.71903559
20Difficulty climbing stairs (HP:0003551)2.70368722
21Increased variability in muscle fiber diameter (HP:0003557)2.68786084
22Atrophic scars (HP:0001075)2.68509397
23Dysmetric saccades (HP:0000641)2.67767557
24Primary atrial arrhythmia (HP:0001692)2.67109664
25Distal upper limb amyotrophy (HP:0007149)2.61319553
26Upper limb amyotrophy (HP:0009129)2.61319553
27Myoglobinuria (HP:0002913)2.60135437
28Vertebral arch anomaly (HP:0008438)2.55072759
29Abnormality of the calf musculature (HP:0001430)2.54342764
30Calf muscle hypertrophy (HP:0008981)2.52894093
31Supraventricular arrhythmia (HP:0005115)2.49375465
32Supraventricular tachycardia (HP:0004755)2.45781357
33Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.45477227
34Macroorchidism (HP:0000053)2.44518826
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.43914605
36Osteolytic defects of the hand bones (HP:0009699)2.43914605
37Hyperacusis (HP:0010780)2.41337877
38Resting tremor (HP:0002322)2.40295871
39Achilles tendon contracture (HP:0001771)2.39486352
40Lymphangioma (HP:0100764)2.39038496
41Type 1 muscle fiber predominance (HP:0003803)2.37674520
42Prolonged QT interval (HP:0001657)2.34355579
43Abnormality of skeletal muscle fiber size (HP:0012084)2.31885312
44Ankle contracture (HP:0006466)2.29562541
45Mildly elevated creatine phosphokinase (HP:0008180)2.29183636
46Ventricular arrhythmia (HP:0004308)2.27708603
47Bladder diverticulum (HP:0000015)2.27543334
48EMG: myopathic abnormalities (HP:0003458)2.25704411
49Abnormality of oral frenula (HP:0000190)2.24101827
50Asymmetric septal hypertrophy (HP:0001670)2.23460996
51Ulnar bowing (HP:0003031)2.23384812
52Mitral valve prolapse (HP:0001634)2.22985978
53Enlarged penis (HP:0000040)2.22314393
54Wormian bones (HP:0002645)2.21764522
55Muscle hypertrophy of the lower extremities (HP:0008968)2.21185917
56Lower limb amyotrophy (HP:0007210)2.20968138
57Abnormality of the Achilles tendon (HP:0005109)2.20925759
58Increased nuchal translucency (HP:0010880)2.19921723
59* Aneurysm (HP:0002617)2.18706434
60Syncope (HP:0001279)2.17791729
61Overgrowth (HP:0001548)2.15931665
62Relative macrocephaly (HP:0004482)2.14213663
63Dilatation of the ascending aorta (HP:0005111)2.13182318
64Lipoatrophy (HP:0100578)2.12694341
65* Bundle branch block (HP:0011710)2.12235006
66Cerebral inclusion bodies (HP:0100314)2.10568389
67Hammertoe (HP:0001765)2.09881618
68Hamartoma of the eye (HP:0010568)2.09751959
69Insomnia (HP:0100785)2.09524447
70Limb-girdle muscle atrophy (HP:0003797)2.09137248
71* Scapular winging (HP:0003691)2.08734434
72Distal lower limb amyotrophy (HP:0008944)2.06764941
73Fragile skin (HP:0001030)2.06075659
74Termporal pattern (HP:0011008)2.04372253
75Insidious onset (HP:0003587)2.04372253
76Long toe (HP:0010511)2.03940681
77Overriding aorta (HP:0002623)2.03168867
78Spinal cord lesions (HP:0100561)2.01249444
79Syringomyelia (HP:0003396)2.01249444
80Aortic aneurysm (HP:0004942)2.00175171
81Bowel diverticulosis (HP:0005222)1.98542963
82Buphthalmos (HP:0000557)1.98362597
83Deep philtrum (HP:0002002)1.98010115
84Turricephaly (HP:0000262)1.96160393
85Hand muscle atrophy (HP:0009130)1.95466664
86Subacute progressive viral hepatitis (HP:0006572)1.95361947
87Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95164655
88Renovascular hypertension (HP:0100817)1.95140062
89Papilledema (HP:0001085)1.94916713
90Action tremor (HP:0002345)1.94572315
91Papillary thyroid carcinoma (HP:0002895)1.94456480
92Myotonia (HP:0002486)1.91786491
93Spinal rigidity (HP:0003306)1.91043518
94Hypoglycemic coma (HP:0001325)1.90793902
95Aortic dissection (HP:0002647)1.89092790
96Mitral regurgitation (HP:0001653)1.88924259
97Frequent falls (HP:0002359)1.87520466
98Ketoacidosis (HP:0001993)1.85799732
99Elfin facies (HP:0004428)1.85772403
100Neonatal short-limb short stature (HP:0008921)1.85515894
101Bronchomalacia (HP:0002780)1.83358030
102Cortical dysplasia (HP:0002539)1.83138107
103Hypercortisolism (HP:0001578)1.82715896
104* Abnormal atrioventricular conduction (HP:0005150)1.82402010
105Breech presentation (HP:0001623)1.82367533
106* Heart block (HP:0012722)1.81972966
107Rapidly progressive (HP:0003678)1.81748607
108Heterotopia (HP:0002282)1.81446805
109Arnold-Chiari malformation (HP:0002308)1.81189465
110Advanced eruption of teeth (HP:0006288)1.80769116
111Pointed chin (HP:0000307)1.80222021
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.80035621
113Hyperglycemia (HP:0003074)1.77430910
114* Atrioventricular block (HP:0001678)1.76719376
115Abnormality of the calcaneus (HP:0008364)1.76669382
116Striae distensae (HP:0001065)1.76666580
117Visual hallucinations (HP:0002367)1.75697228
118Thin bony cortex (HP:0002753)1.75569828
119Hyperinsulinemic hypoglycemia (HP:0000825)1.75330384
120Deviation of the thumb (HP:0009603)1.74946591
121Rectal prolapse (HP:0002035)1.74132500
122Back pain (HP:0003418)1.73459850
123Flat cornea (HP:0007720)1.71849018
124Proximal amyotrophy (HP:0007126)1.71802063
125Abnormality of the lower motor neuron (HP:0002366)1.71151868
126Neoplasm of the heart (HP:0100544)1.70895195
127Dilated cardiomyopathy (HP:0001644)1.70258657
128Scanning speech (HP:0002168)1.69739421
129Genu recurvatum (HP:0002816)1.69699595
130Ankyloglossia (HP:0010296)1.69246044
131Abnormal EKG (HP:0003115)1.69179523
132Hemiplegia (HP:0002301)1.67327358
133Short nail (HP:0001799)1.67232504
134Depression (HP:0000716)1.66802919
135Neurofibrillary tangles (HP:0002185)1.66555760
136Renal duplication (HP:0000075)1.66167825
137Limb-girdle muscle weakness (HP:0003325)1.65200479
138Obstructive sleep apnea (HP:0002870)1.64676440
139Vertebral compression fractures (HP:0002953)1.64378197
140Broad face (HP:0000283)1.63895977
141Mild short stature (HP:0003502)1.63166689
142Coronal craniosynostosis (HP:0004440)1.63123122
143Abnormality of dentin (HP:0010299)1.62746407
144Flat acetabular roof (HP:0003180)1.61731572
145Selective tooth agenesis (HP:0001592)1.60553250
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.60432189
147Patellar dislocation (HP:0002999)1.59542922
148Abnormality of pain sensation (HP:0010832)1.56550777
149Impaired pain sensation (HP:0007328)1.56550777
150Spinal cord compression (HP:0002176)1.54628536
151Sparse lateral eyebrow (HP:0005338)1.52400547
152Soft skin (HP:0000977)1.51780592
153Disproportionate tall stature (HP:0001519)1.50534371
154Natal tooth (HP:0000695)1.50461327
155Mitral stenosis (HP:0001718)1.50392787
156Absent frontal sinuses (HP:0002688)1.50082259
157Pheochromocytoma (HP:0002666)1.49897524
158Wide anterior fontanel (HP:0000260)1.49824226
159Proximal placement of thumb (HP:0009623)1.49747345
160Decreased motor nerve conduction velocity (HP:0003431)1.48494095
161Aplasia of the phalanges of the hand (HP:0009802)1.48396073
162Aplasia involving bones of the extremities (HP:0009825)1.48396073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.95160879
2PKN23.51829858
3TTN3.41714455
4PRKD32.42157863
5LATS12.30389418
6RIPK12.24557301
7LMTK22.19992013
8KSR22.10586504
9MST1R2.09301020
10LATS21.90243391
11DMPK1.86571351
12MAP3K91.86293363
13SMG11.84330873
14PAK61.81240888
15EEF2K1.78529414
16PTK61.61813565
17CAMKK11.59104347
18BRD41.57985363
19SIK11.55897720
20DDR21.55364558
21PAK31.53549462
22ERBB41.52867777
23TSSK61.48402054
24TTK1.46624473
25RET1.45672842
26* PDGFRA1.44778581
27STK381.40977343
28NTRK11.39323884
29MAP3K21.38328615
30PHKG11.38032446
31PHKG21.38032446
32CAMK1G1.37030003
33TAOK11.36691476
34EIF2AK11.36608050
35TYRO31.35644468
36CAMK1D1.30076544
37PBK1.29581714
38NTRK31.24519440
39PRPF4B1.24409852
40BMX1.22863598
41NEK91.20426196
42PNCK1.20116552
43SCYL21.17538609
44EPHA21.15107477
45NEK11.14616985
46SRPK11.11466987
47IRAK31.11242647
48STK38L1.10183480
49CDC71.09431168
50NEK21.06916412
51PTK21.01897358
52FGFR21.01624154
53WNK11.01325856
54PRKD10.99131917
55CDC42BPA0.99014322
56FER0.98549345
57ERN10.98149932
58MAP3K40.97585434
59MTOR0.93308250
60RPS6KB20.92576165
61MAP3K70.92325384
62KSR10.90267348
63PAK20.89721182
64MOS0.89418623
65MAP3K100.88017288
66EPHA40.87830852
67LRRK20.85386032
68PDPK10.81046653
69MAP3K10.79232772
70DAPK20.79040928
71MAP2K40.78843418
72ICK0.78433599
73PDK40.77391981
74PDK30.77391981
75MINK10.77157208
76FRK0.77068428
77TAF10.76890798
78ROCK10.76853114
79ARAF0.72001624
80STK110.71849076
81CAMKK20.71567254
82MAP2K10.71170736
83AKT30.70537880
84ERBB30.70450634
85SGK30.70113652
86INSRR0.69807420
87ILK0.69671709
88FGFR10.69591810
89OBSCN0.67832851
90CDK70.66987982
91MARK20.66955482
92PDK10.66277342
93EPHB10.66166058
94* PDGFRB0.66110428
95MAP3K130.65325050
96CDK180.65162027
97CDK150.65004411
98CHEK10.63601538
99BRAF0.63448687
100FGFR30.63333395
101* PRKCH0.63119008
102PRKAA10.61105285
103CDK50.59981623
104AKT20.59759224
105NEK60.59481210
106MAP3K80.59399008
107CAMK2B0.58823975
108CDK11A0.58329417
109MAP3K60.57622702
110CLK10.56072654
111CDK140.55111447
112UHMK10.54799632
113HIPK20.53651085
114EIF2AK30.53380328
115PRKD20.53154020
116MKNK10.53061427
117ROCK20.52974473
118* ALK0.51998197
119RPS6KB10.50649613
120AURKB0.49999123
121RPS6KA40.49954476
122STK30.48977351
123WNK40.48431924
124CDK10.47994535
125WEE10.47936939
126YES10.47582996
127CSNK1E0.47167548
128TESK10.46824823
129PTK2B0.46619977
130CDK120.46616812
131FGFR40.46352287
132MELK0.46160355
133CDK60.45822746
134PIK3CA0.45491348
135RAF10.44796103
136SIK20.44629226
137MET0.44487781
138CHEK20.44270653
139RPS6KA30.43747177
140CAMK2G0.43339218
141EPHB20.43111894
142PINK10.42954791
143EIF2AK20.42307045
144TRPM70.42280989
145NTRK20.42229989
146SGK10.41960775
147PLK30.41581739
148BUB10.40926809
149BRSK10.40425310
150CAMK2D0.39393876
151PAK40.38524988
152PRKAA20.38005981
153RPS6KA20.37835093
154MAPK100.34458203
155MARK10.33123593

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.55973319
2Dilated cardiomyopathy_Homo sapiens_hsa054142.06669205
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06379716
4Thyroid cancer_Homo sapiens_hsa052161.88826920
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70907706
6Type II diabetes mellitus_Homo sapiens_hsa049301.67821976
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64701250
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62074117
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59888501
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59010164
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57869932
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57646986
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56017297
14Vitamin B6 metabolism_Homo sapiens_hsa007501.54372306
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49949217
16MicroRNAs in cancer_Homo sapiens_hsa052061.44915238
17Focal adhesion_Homo sapiens_hsa045101.38673407
18mTOR signaling pathway_Homo sapiens_hsa041501.38115683
19Glioma_Homo sapiens_hsa052141.33399079
20Insulin secretion_Homo sapiens_hsa049111.33321073
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29985007
22Long-term potentiation_Homo sapiens_hsa047201.27839272
23Cell cycle_Homo sapiens_hsa041101.27291640
24Gastric acid secretion_Homo sapiens_hsa049711.26537661
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24090013
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24027690
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21247568
28Estrogen signaling pathway_Homo sapiens_hsa049151.20916132
29* Insulin resistance_Homo sapiens_hsa049311.18486872
30Dorso-ventral axis formation_Homo sapiens_hsa043201.15337507
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14962750
32Biosynthesis of amino acids_Homo sapiens_hsa012301.14503318
33Insulin signaling pathway_Homo sapiens_hsa049101.14077172
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13640361
35Circadian entrainment_Homo sapiens_hsa047131.12892724
36Oxytocin signaling pathway_Homo sapiens_hsa049211.12316096
37mRNA surveillance pathway_Homo sapiens_hsa030151.11585469
38GnRH signaling pathway_Homo sapiens_hsa049121.09916406
39Renin secretion_Homo sapiens_hsa049241.09782094
40Cholinergic synapse_Homo sapiens_hsa047251.09336669
41Prion diseases_Homo sapiens_hsa050201.09098912
42ECM-receptor interaction_Homo sapiens_hsa045121.08906061
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08624335
44* Proteoglycans in cancer_Homo sapiens_hsa052051.08183940
45Colorectal cancer_Homo sapiens_hsa052101.07154282
46Gap junction_Homo sapiens_hsa045401.07001985
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06342374
48Prostate cancer_Homo sapiens_hsa052151.05720633
49Glucagon signaling pathway_Homo sapiens_hsa049221.05314698
50AMPK signaling pathway_Homo sapiens_hsa041521.03698316
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.02831504
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02000167
53Dopaminergic synapse_Homo sapiens_hsa047281.00590592
54Endometrial cancer_Homo sapiens_hsa052130.99239053
55Salivary secretion_Homo sapiens_hsa049700.99121953
56Fatty acid degradation_Homo sapiens_hsa000710.98314543
57Adherens junction_Homo sapiens_hsa045200.97457675
58GABAergic synapse_Homo sapiens_hsa047270.95962507
59Propanoate metabolism_Homo sapiens_hsa006400.95446621
60Olfactory transduction_Homo sapiens_hsa047400.95226439
61* Adipocytokine signaling pathway_Homo sapiens_hsa049200.95143982
62Amoebiasis_Homo sapiens_hsa051460.94599637
63Fatty acid metabolism_Homo sapiens_hsa012120.94324170
64Cocaine addiction_Homo sapiens_hsa050300.93808156
65cAMP signaling pathway_Homo sapiens_hsa040240.93587764
66VEGF signaling pathway_Homo sapiens_hsa043700.93211750
67Amphetamine addiction_Homo sapiens_hsa050310.93080961
68Melanoma_Homo sapiens_hsa052180.92443601
69Glutamatergic synapse_Homo sapiens_hsa047240.91306725
70Arginine biosynthesis_Homo sapiens_hsa002200.91044837
71Non-small cell lung cancer_Homo sapiens_hsa052230.90810582
72PPAR signaling pathway_Homo sapiens_hsa033200.88633472
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88272639
74Lysine degradation_Homo sapiens_hsa003100.87811743
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86979681
76Inositol phosphate metabolism_Homo sapiens_hsa005620.86743157
77Tight junction_Homo sapiens_hsa045300.85934272
78Oocyte meiosis_Homo sapiens_hsa041140.85682891
79Fatty acid biosynthesis_Homo sapiens_hsa000610.85566191
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.85336503
81* Chronic myeloid leukemia_Homo sapiens_hsa052200.85023829
82Pentose phosphate pathway_Homo sapiens_hsa000300.84508286
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84196920
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83931333
85Bile secretion_Homo sapiens_hsa049760.83071207
86RNA transport_Homo sapiens_hsa030130.82538641
87Cardiac muscle contraction_Homo sapiens_hsa042600.82362694
88* Renal cell carcinoma_Homo sapiens_hsa052110.80481054
89Non-homologous end-joining_Homo sapiens_hsa034500.79920583
90Melanogenesis_Homo sapiens_hsa049160.79451075
91* Phospholipase D signaling pathway_Homo sapiens_hsa040720.79132535
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78820000
93Thyroid hormone synthesis_Homo sapiens_hsa049180.78042555
94ErbB signaling pathway_Homo sapiens_hsa040120.77296092
95Morphine addiction_Homo sapiens_hsa050320.74916785
96Platelet activation_Homo sapiens_hsa046110.73228021
97Viral myocarditis_Homo sapiens_hsa054160.73163629
98Synaptic vesicle cycle_Homo sapiens_hsa047210.72659557
99Bladder cancer_Homo sapiens_hsa052190.72453835
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72452822
101* Neurotrophin signaling pathway_Homo sapiens_hsa047220.72262993
102Wnt signaling pathway_Homo sapiens_hsa043100.71819602
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71204032
104Rap1 signaling pathway_Homo sapiens_hsa040150.70781567
105Long-term depression_Homo sapiens_hsa047300.70551236
106Pathways in cancer_Homo sapiens_hsa052000.69520405
107TGF-beta signaling pathway_Homo sapiens_hsa043500.68792639
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68742117
109Carbon metabolism_Homo sapiens_hsa012000.67721368
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67609414
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67591233
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66760862
113DNA replication_Homo sapiens_hsa030300.66465661
114Butanoate metabolism_Homo sapiens_hsa006500.66378187
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65956250
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65372667
117Pancreatic secretion_Homo sapiens_hsa049720.65040991
118One carbon pool by folate_Homo sapiens_hsa006700.64995156
119Prolactin signaling pathway_Homo sapiens_hsa049170.63369393
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.63045699
121Calcium signaling pathway_Homo sapiens_hsa040200.62939028
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62813685
123Small cell lung cancer_Homo sapiens_hsa052220.62475455
124Hippo signaling pathway_Homo sapiens_hsa043900.61911964
125Circadian rhythm_Homo sapiens_hsa047100.61879149
126Pancreatic cancer_Homo sapiens_hsa052120.61778144
127Acute myeloid leukemia_Homo sapiens_hsa052210.61595775
128Endocytosis_Homo sapiens_hsa041440.61259593
129Choline metabolism in cancer_Homo sapiens_hsa052310.60417262
130Axon guidance_Homo sapiens_hsa043600.59023114
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58357472
132HIF-1 signaling pathway_Homo sapiens_hsa040660.55102113
133FoxO signaling pathway_Homo sapiens_hsa040680.54755602
134Pyruvate metabolism_Homo sapiens_hsa006200.54621210
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53061214
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51003304

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