PTPN13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.60686317
2desmosome organization (GO:0002934)4.69359672
3paraxial mesoderm development (GO:0048339)4.56407820
4hippo signaling (GO:0035329)4.32420779
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.19950257
6mesodermal cell differentiation (GO:0048333)4.07474893
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.04349296
8lung-associated mesenchyme development (GO:0060484)4.00726799
9lateral sprouting from an epithelium (GO:0060601)3.84007641
10regulation of transforming growth factor beta2 production (GO:0032909)3.83902091
11collecting duct development (GO:0072044)3.81348590
12regulation of hippo signaling (GO:0035330)3.73528058
13mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.59862067
14cell adhesion mediated by integrin (GO:0033627)3.47757381
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.38668061
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.33117178
17regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.32624738
18artery development (GO:0060840)3.31733618
19polarized epithelial cell differentiation (GO:0030859)3.30047208
20establishment of tissue polarity (GO:0007164)3.22896596
21establishment of planar polarity (GO:0001736)3.22896596
22regulation of water loss via skin (GO:0033561)3.20324727
23establishment of apical/basal cell polarity (GO:0035089)3.19962946
24keratinocyte differentiation (GO:0030216)3.19638541
25renal filtration (GO:0097205)3.18406806
26embryonic foregut morphogenesis (GO:0048617)3.17491434
27neuron projection extension involved in neuron projection guidance (GO:1902284)3.16845450
28axon extension involved in axon guidance (GO:0048846)3.16845450
29convergent extension (GO:0060026)3.11949326
30male genitalia development (GO:0030539)3.11446311
31nuclear pore complex assembly (GO:0051292)3.09366028
32negative regulation of cell fate specification (GO:0009996)3.05650079
33notochord development (GO:0030903)3.05003436
34non-canonical Wnt signaling pathway (GO:0035567)3.04716197
35mesenchymal to epithelial transition (GO:0060231)3.02752451
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01637063
37regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.99158890
38outer ear morphogenesis (GO:0042473)2.99129528
39lung epithelium development (GO:0060428)2.98594805
40establishment of skin barrier (GO:0061436)2.98081076
41epithelial cell-cell adhesion (GO:0090136)2.97941344
42embryonic camera-type eye development (GO:0031076)2.96909690
43Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93966467
44nuclear pore organization (GO:0006999)2.93581815
45morphogenesis of an epithelial sheet (GO:0002011)2.92363827
46cell-substrate junction assembly (GO:0007044)2.90887858
47regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.90801157
48regulation of establishment of planar polarity (GO:0090175)2.89947786
49ectoderm development (GO:0007398)2.87797392
50branching involved in salivary gland morphogenesis (GO:0060445)2.86583242
51genitalia morphogenesis (GO:0035112)2.85033943
52negative regulation of axon extension involved in axon guidance (GO:0048843)2.84586819
53mesenchyme development (GO:0060485)2.84009069
54skin morphogenesis (GO:0043589)2.82968473
55regulation of cell fate specification (GO:0042659)2.82339715
56prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.82030259
57negative regulation of hormone biosynthetic process (GO:0032353)2.81789073
58asymmetric protein localization (GO:0008105)2.80122082
59cell surface receptor signaling pathway involved in heart development (GO:0061311)2.79949114
60positive regulation of catenin import into nucleus (GO:0035413)2.79712216
61respiratory tube development (GO:0030323)2.79667874
62renal system development (GO:0072001)2.78094570
63establishment of monopolar cell polarity (GO:0061162)2.76776257
64establishment or maintenance of monopolar cell polarity (GO:0061339)2.76776257
65regulation of sister chromatid cohesion (GO:0007063)2.76223960
66epidermal cell differentiation (GO:0009913)2.76024602
67regulation of cardioblast differentiation (GO:0051890)2.75572898
68glial cell proliferation (GO:0014009)2.74645043
69retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74282390
70negative regulation of DNA repair (GO:0045738)2.74101004
71dorsal/ventral axis specification (GO:0009950)2.73862817
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70238904
73regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.69544977
74mesenchymal-epithelial cell signaling (GO:0060638)2.68834732
75cytoskeletal anchoring at plasma membrane (GO:0007016)2.68162643
76regulation of gene silencing by RNA (GO:0060966)2.67989991
77regulation of posttranscriptional gene silencing (GO:0060147)2.67989991
78regulation of gene silencing by miRNA (GO:0060964)2.67989991
79regulation of catenin import into nucleus (GO:0035412)2.67822021
80gastrulation with mouth forming second (GO:0001702)2.67160461
81reproductive system development (GO:0061458)2.66903716
82positive regulation of cardiac muscle cell proliferation (GO:0060045)2.66194745
83keratinization (GO:0031424)2.65831615
84nephron tubule formation (GO:0072079)2.64136262
85negative regulation of catenin import into nucleus (GO:0035414)2.61544338
86epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60539947
87mitotic sister chromatid cohesion (GO:0007064)2.59676318
88lens fiber cell development (GO:0070307)2.59615380
89establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59454539
90tight junction assembly (GO:0070830)2.59104761
91mesenchymal cell differentiation (GO:0048762)2.58731570
92head development (GO:0060322)2.58689837
93gap junction assembly (GO:0016264)2.58324295
94negative chemotaxis (GO:0050919)2.58246772
95interferon-gamma secretion (GO:0072643)2.57956545
96multicellular organismal water homeostasis (GO:0050891)2.56892707
97regulation of heart morphogenesis (GO:2000826)2.56864030
98negative regulation of keratinocyte proliferation (GO:0010839)2.56858001
99cardiac myofibril assembly (GO:0055003)2.56078502
100establishment of nucleus localization (GO:0040023)2.55968563
101positive regulation of cardiac muscle tissue development (GO:0055025)2.55384582
102negative regulation of chondrocyte differentiation (GO:0032331)2.54708791
103keratinocyte proliferation (GO:0043616)2.52964828
104positive regulation of hormone biosynthetic process (GO:0046886)2.52053081
105glomerular basement membrane development (GO:0032836)2.51950818
106regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.50429206
107regulation of keratinocyte proliferation (GO:0010837)2.49438761
108apical protein localization (GO:0045176)2.48749811
109regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48205235
110establishment or maintenance of apical/basal cell polarity (GO:0035088)2.48116617
111establishment or maintenance of bipolar cell polarity (GO:0061245)2.48116617
112regulation of glomerular filtration (GO:0003093)2.47175631
113bone trabecula formation (GO:0060346)2.46990495
114lung lobe morphogenesis (GO:0060463)2.46263901
115atrioventricular valve morphogenesis (GO:0003181)2.46213624
116positive regulation of epithelial to mesenchymal transition (GO:0010718)2.45945236
117organ formation (GO:0048645)2.45592256
118presynaptic membrane assembly (GO:0097105)2.44391393
119axis elongation (GO:0003401)2.44263474
120positive regulation of cardiac muscle tissue growth (GO:0055023)2.44146630
121mesenchyme morphogenesis (GO:0072132)2.43567372
122mesenchymal cell proliferation (GO:0010463)2.43030939
123regulation of SMAD protein import into nucleus (GO:0060390)2.42128123
124otic vesicle formation (GO:0030916)2.41938089
125cochlea morphogenesis (GO:0090103)2.41127956
126camera-type eye morphogenesis (GO:0048593)2.39878650
127pre-miRNA processing (GO:0031054)2.38940204
128positive regulation of SMAD protein import into nucleus (GO:0060391)2.38116272
129anterior/posterior axis specification, embryo (GO:0008595)2.37302523
130embryonic digestive tract morphogenesis (GO:0048557)2.36247186
131metanephric mesenchyme development (GO:0072075)2.36139390
132molting cycle (GO:0042303)2.36072268
133hair cycle (GO:0042633)2.36072268
134appendage development (GO:0048736)2.34074428
135limb development (GO:0060173)2.34074428
136pericardium development (GO:0060039)2.31190123
137limb bud formation (GO:0060174)2.29840357
138tube closure (GO:0060606)2.29219372
139negative regulation of hormone metabolic process (GO:0032351)2.29062437
140negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.27224495
141regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.26936575
142negative regulation of translation, ncRNA-mediated (GO:0040033)2.26834433
143regulation of translation, ncRNA-mediated (GO:0045974)2.26834433
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.26834433
145neural tube closure (GO:0001843)2.25753557
146chondrocyte proliferation (GO:0035988)2.24408095
147regulation of centriole replication (GO:0046599)2.24326089
148radial glial cell differentiation (GO:0060019)2.23955459
149positive regulation of smoothened signaling pathway (GO:0045880)2.22092341
150cerebral cortex radially oriented cell migration (GO:0021799)2.21213441
151embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20471486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.88370467
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.79681529
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.37435535
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20297218
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.60058276
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54790702
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48700111
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.48352610
9GBX2_23144817_ChIP-Seq_PC3_Human2.24360074
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.23870769
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20421434
12FUS_26573619_Chip-Seq_HEK293_Human2.19326930
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.14514046
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11491130
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.09367596
16* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.08646991
17AR_21909140_ChIP-Seq_LNCAP_Human2.03454673
18CLOCK_20551151_ChIP-Seq_293T_Human1.92348120
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91282557
20* FOXO3_23340844_ChIP-Seq_DLD1_Human1.90764678
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89532995
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88585714
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88585714
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88391711
25* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81534440
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74045472
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71359186
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69796034
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67718177
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66103019
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65833001
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65279733
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61598498
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61569444
35SMAD4_21799915_ChIP-Seq_A2780_Human1.59933290
36* P300_19829295_ChIP-Seq_ESCs_Human1.59586666
37AHR_22903824_ChIP-Seq_MCF-7_Human1.59215827
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.57239681
39ISL1_27105846_Chip-Seq_CPCs_Mouse1.55688749
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53115186
41* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52452000
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52238075
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.51108408
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50914085
45CJUN_26792858_Chip-Seq_BT549_Human1.48086895
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.47970646
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47921687
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47664552
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47452133
50FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.47189842
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46161910
52TAF15_26573619_Chip-Seq_HEK293_Human1.45790188
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44268450
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43291390
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.42994556
56EWS_26573619_Chip-Seq_HEK293_Human1.41833892
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.41165954
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39910232
59* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39815691
60BRD4_25478319_ChIP-Seq_HGPS_Human1.39219929
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38141419
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37224614
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.36943499
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36715507
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36712971
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.34837630
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34398657
68* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33304116
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33155304
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.32239039
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32182970
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.31902112
73GATA6_25053715_ChIP-Seq_YYC3_Human1.30961484
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30919561
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30867505
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29897469
77SOX9_26525672_Chip-Seq_HEART_Mouse1.29884973
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.29539602
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28199045
80KLF5_25053715_ChIP-Seq_YYC3_Human1.26933164
81* SMAD3_21741376_ChIP-Seq_HESCs_Human1.25587342
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25091031
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24870830
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24705382
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.23980323
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23873377
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23542826
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23542826
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23542826
90* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22509765
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22178841
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21847951
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21575931
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21575931
95* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20274718
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19834270
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19312861
98ZNF263_19887448_ChIP-Seq_K562_Human1.18290903
99AR_21572438_ChIP-Seq_LNCaP_Human1.18183314
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17160458
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.16840874
102EZH2_22144423_ChIP-Seq_EOC_Human1.16713561
103* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16409185
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16396311
105* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16258985
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15975398
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15766482
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14983591
109* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14282947
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.13849273
111STAT3_23295773_ChIP-Seq_U87_Human1.13843964
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.13498060
113RACK7_27058665_Chip-Seq_MCF-7_Human1.13374870
114SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13067018
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12752449
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12752449
117TP53_16413492_ChIP-PET_HCT116_Human1.11810663
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.11461052
119* ATF3_27146783_Chip-Seq_COLON_Human1.10717348
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09297027
121GATA4_25053715_ChIP-Seq_YYC3_Human1.08756890
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08745745
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08642491
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.08201914
125E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07963568
126GATA1_26923725_Chip-Seq_HPCs_Mouse1.07675027
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07629515
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07424742
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07242782
130ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07056736
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06946018
132* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06191687
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.05604609
134RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05119049
135EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05119049
136POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05034932
137* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03254963
138CHD1_26751641_Chip-Seq_LNCaP_Human1.03063365
139* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02832520
140* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02824949
141TP53_18474530_ChIP-ChIP_U2OS_Human1.02475482
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01272195
143* SOX2_20726797_ChIP-Seq_SW620_Human1.00124469
144PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98519353
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.98482497
146SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97619551
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96367430
148* RING1B_27294783_Chip-Seq_NPCs_Mouse0.96320175
149E2F7_22180533_ChIP-Seq_HELA_Human0.95591902
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94638708
151* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94528753
152* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93963867
153* TP63_23658742_ChIP-Seq_EP156T_Human0.93419255
154GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92513686
155TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90411702
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.89072491
157* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88838616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.85375940
2MP0002254_reproductive_system_inflammat3.71725770
3MP0010234_abnormal_vibrissa_follicle3.39075457
4MP0003941_abnormal_skin_development3.02680584
5MP0000383_abnormal_hair_follicle2.85965042
6MP0010030_abnormal_orbit_morphology2.83284996
7MP0010678_abnormal_skin_adnexa2.80321186
8MP0005275_abnormal_skin_tensile2.79579029
9MP0001346_abnormal_lacrimal_gland2.58454078
10MP0004272_abnormal_basement_membrane2.45798493
11MP0000566_synostosis2.43355137
12MP0003705_abnormal_hypodermis_morpholog2.43088543
13MP0002796_impaired_skin_barrier2.42962842
14MP0009053_abnormal_anal_canal2.31786196
15MP0000579_abnormal_nail_morphology2.20232946
16MP0010352_gastrointestinal_tract_polyps2.06081231
17MP0002098_abnormal_vibrissa_morphology1.99843513
18MP0009384_cardiac_valve_regurgitation1.98074000
19MP0005623_abnormal_meninges_morphology1.89102067
20MP0002102_abnormal_ear_morphology1.72995788
21MP0003937_abnormal_limbs/digits/tail_de1.71970559
22MP0003566_abnormal_cell_adhesion1.70528268
23MP0005501_abnormal_skin_physiology1.67906123
24MP0003942_abnormal_urinary_system1.66903629
25MP0000534_abnormal_ureter_morphology1.61347984
26MP0003453_abnormal_keratinocyte_physiol1.61088640
27MP0000647_abnormal_sebaceous_gland1.56379077
28MP0002060_abnormal_skin_morphology1.54727160
29MP0008057_abnormal_DNA_replication1.52590677
30MP0000428_abnormal_craniofacial_morphol1.51212228
31MP0001849_ear_inflammation1.50654054
32MP0000762_abnormal_tongue_morphology1.50605195
33MP0005076_abnormal_cell_differentiation1.50405165
34MP0006292_abnormal_olfactory_placode1.48603710
35MP0003115_abnormal_respiratory_system1.48165038
36MP0000377_abnormal_hair_follicle1.47569523
37MP0009780_abnormal_chondrocyte_physiolo1.47044500
38MP0001216_abnormal_epidermal_layer1.44504579
39MP0005367_renal/urinary_system_phenotyp1.39749510
40MP0000516_abnormal_urinary_system1.39749510
41MP0005257_abnormal_intraocular_pressure1.39321032
42MP0008438_abnormal_cutaneous_collagen1.36463743
43MP0000778_abnormal_nervous_system1.36299415
44MP0003890_abnormal_embryonic-extraembry1.35734479
45MP0003755_abnormal_palate_morphology1.34112657
46MP0009672_abnormal_birth_weight1.33707625
47MP0000467_abnormal_esophagus_morphology1.33066299
48MP0001293_anophthalmia1.31350348
49MP0003385_abnormal_body_wall1.28443064
50MP0003935_abnormal_craniofacial_develop1.28245435
51MP0000432_abnormal_head_morphology1.27061987
52MP0000427_abnormal_hair_cycle1.26182340
53MP0002233_abnormal_nose_morphology1.24935611
54MP0002234_abnormal_pharynx_morphology1.23613176
55MP0001177_atelectasis1.21758063
56MP0001299_abnormal_eye_distance/1.19747735
57MP0005377_hearing/vestibular/ear_phenot1.19655821
58MP0003878_abnormal_ear_physiology1.19655821
59MP0002697_abnormal_eye_size1.19647164
60MP0003315_abnormal_perineum_morphology1.19324495
61MP0005248_abnormal_Harderian_gland1.18849893
62MP0002084_abnormal_developmental_patter1.18554528
63MP0003300_gastrointestinal_ulcer1.16467995
64MP0005508_abnormal_skeleton_morphology1.16379296
65MP0002092_abnormal_eye_morphology1.15988910
66MP0000733_abnormal_muscle_development1.15886180
67MP0003119_abnormal_digestive_system1.15731835
68MP0002938_white_spotting1.14960849
69MP0001958_emphysema1.13777605
70MP0003136_yellow_coat_color1.13094999
71MP0010771_integument_phenotype1.12509803
72MP0002282_abnormal_trachea_morphology1.12274004
73MP0009250_abnormal_appendicular_skeleto1.10412561
74MP0003861_abnormal_nervous_system1.09128609
75MP0003123_paternal_imprinting1.09112391
76MP0004264_abnormal_extraembryonic_tissu1.08753577
77MP0005503_abnormal_tendon_morphology1.07624378
78MP0005187_abnormal_penis_morphology1.06586042
79MP0005023_abnormal_wound_healing1.05779777
80MP0001348_abnormal_lacrimal_gland1.04290684
81MP0001286_abnormal_eye_development1.02772333
82MP0002085_abnormal_embryonic_tissue1.02716361
83MP0005197_abnormal_uvea_morphology1.02392029
84MP0002932_abnormal_joint_morphology1.01917415
85MP0002111_abnormal_tail_morphology1.01686096
86MP0003045_fibrosis0.99346021
87MP0002116_abnormal_craniofacial_bone0.98652667
88MP0000049_abnormal_middle_ear0.98584210
89MP0006054_spinal_hemorrhage0.97775629
90MP0003984_embryonic_growth_retardation0.97574452
91MP0002088_abnormal_embryonic_growth/wei0.96344312
92MP0004197_abnormal_fetal_growth/weight/0.95077665
93MP0005391_vision/eye_phenotype0.93013148
94MP0005499_abnormal_olfactory_system0.92914353
95MP0005394_taste/olfaction_phenotype0.92914353
96MP0002249_abnormal_larynx_morphology0.92493665
97MP0002109_abnormal_limb_morphology0.92329999
98MP0001340_abnormal_eyelid_morphology0.91257689
99MP0002177_abnormal_outer_ear0.90909472
100MP0004133_heterotaxia0.90252624
101MP0002896_abnormal_bone_mineralization0.88656737
102MP0003936_abnormal_reproductive_system0.88307627
103MP0000613_abnormal_salivary_gland0.88149144
104MP0004782_abnormal_surfactant_physiolog0.86211510
105MP0008789_abnormal_olfactory_epithelium0.85957644
106MP0000627_abnormal_mammary_gland0.85891296
107MP0000462_abnormal_digestive_system0.85019397
108MP0002653_abnormal_ependyma_morphology0.84955124
109MP0002114_abnormal_axial_skeleton0.82299834
110MP0003567_abnormal_fetal_cardiomyocyte0.82032437
111MP0003091_abnormal_cell_migration0.81063997
112MP0004185_abnormal_adipocyte_glucose0.80343492
113MP0002081_perinatal_lethality0.79114015
114MP0003121_genomic_imprinting0.78867771
115MP0009703_decreased_birth_body0.78806750
116MP0006072_abnormal_retinal_apoptosis0.77756336
117MP0005380_embryogenesis_phenotype0.77322883
118MP0001672_abnormal_embryogenesis/_devel0.77322883
119MP0003938_abnormal_ear_development0.76296328
120MP0002925_abnormal_cardiovascular_devel0.75627813
121MP0008932_abnormal_embryonic_tissue0.75370056
122MP0010307_abnormal_tumor_latency0.73466992
123MP0002086_abnormal_extraembryonic_tissu0.73435193
124MP0003283_abnormal_digestive_organ0.72807473
125MP0004957_abnormal_blastocyst_morpholog0.72420934
126MP0001697_abnormal_embryo_size0.71197562

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)3.70628805
2Atrophic scars (HP:0001075)3.53632102
3Onycholysis (HP:0001806)3.21028686
4Partial duplication of thumb phalanx (HP:0009944)3.08813555
5Partial duplication of the phalanx of hand (HP:0009999)2.99068585
6Pili torti (HP:0003777)2.97528107
7Shallow orbits (HP:0000586)2.94810205
8Fragile nails (HP:0001808)2.90078036
9Right ventricular cardiomyopathy (HP:0011663)2.80925064
10Natal tooth (HP:0000695)2.71948290
11Bifid tongue (HP:0010297)2.71684580
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69370658
13Short 4th metacarpal (HP:0010044)2.69370658
14Preaxial foot polydactyly (HP:0001841)2.62061100
15Woolly hair (HP:0002224)2.60080812
16Abnormality of the ischium (HP:0003174)2.56497180
17Ankle contracture (HP:0006466)2.55421166
18Lip pit (HP:0100267)2.51728738
19Hypoplastic labia majora (HP:0000059)2.48121957
20Plantar hyperkeratosis (HP:0007556)2.44002079
21Selective tooth agenesis (HP:0001592)2.43983833
22Hepatoblastoma (HP:0002884)2.31578976
23Myelomeningocele (HP:0002475)2.31131215
24Vitreoretinal degeneration (HP:0000655)2.27365968
25Protrusio acetabuli (HP:0003179)2.26281009
26Hypotrichosis (HP:0001006)2.26115198
27Nail dystrophy (HP:0008404)2.25176801
28Premature rupture of membranes (HP:0001788)2.25097562
29Focal segmental glomerulosclerosis (HP:0000097)2.23328941
30Hypoplasia of dental enamel (HP:0006297)2.20024813
31Abnormality of the labia majora (HP:0012881)2.19987628
32Duplication of thumb phalanx (HP:0009942)2.18216208
33Advanced eruption of teeth (HP:0006288)2.17687416
34Papillary thyroid carcinoma (HP:0002895)2.16790061
35Esophageal atresia (HP:0002032)2.14543307
36Septo-optic dysplasia (HP:0100842)2.14386288
37Bicornuate uterus (HP:0000813)2.12036406
38Rectal prolapse (HP:0002035)2.11275081
39Alopecia of scalp (HP:0002293)2.10482906
40High anterior hairline (HP:0009890)2.08883505
41Fragile skin (HP:0001030)2.07775335
42Vertebral arch anomaly (HP:0008438)2.06243726
43Omphalocele (HP:0001539)2.06142978
44Follicular hyperkeratosis (HP:0007502)2.04141886
45Intestinal atresia (HP:0011100)2.03140696
46Unilateral renal agenesis (HP:0000122)2.01810553
47Abnormality of the nasal septum (HP:0000419)2.00496111
48Aplasia involving bones of the extremities (HP:0009825)1.98446451
49Aplasia involving bones of the upper limbs (HP:0009823)1.98446451
50Aplasia of the phalanges of the hand (HP:0009802)1.98446451
51Abnormality of the distal phalanx of the thumb (HP:0009617)1.98324804
52Cerebral aneurysm (HP:0004944)1.98124027
53Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93348725
54Pterygium (HP:0001059)1.92029728
55Broad thumb (HP:0011304)1.91888208
56Absent eyelashes (HP:0000561)1.91411946
57Aortic dissection (HP:0002647)1.91212166
58Bronchomalacia (HP:0002780)1.90826055
59Aortic aneurysm (HP:0004942)1.90612921
60Renal hypoplasia (HP:0000089)1.89891013
61Midline defect of the nose (HP:0004122)1.89596807
62Aplasia cutis congenita (HP:0001057)1.87978265
63Vascular tortuosity (HP:0004948)1.86564499
64Abnormality of the 4th metacarpal (HP:0010012)1.86346717
65Overgrowth (HP:0001548)1.85648871
66Anal stenosis (HP:0002025)1.85477627
67Cutaneous finger syndactyly (HP:0010554)1.84864658
68Synostosis of carpal bones (HP:0005048)1.84309167
69Bell-shaped thorax (HP:0001591)1.84292406
70Absent eyebrow (HP:0002223)1.83600155
71Broad long bones (HP:0005622)1.82506749
72Coronal craniosynostosis (HP:0004440)1.82375081
73Glomerulosclerosis (HP:0000096)1.81561577
74Renal dysplasia (HP:0000110)1.80303765
75Abnormality of the gastric mucosa (HP:0004295)1.77893322
76Abnormality of the phalanges of the hallux (HP:0010057)1.77766285
77Cutaneous syndactyly (HP:0012725)1.77159606
78Morphological abnormality of the middle ear (HP:0008609)1.77093687
79Abnormality of the middle phalanges of the toes (HP:0010183)1.76994550
80Abnormality of the antihelix (HP:0009738)1.76959564
81Renal duplication (HP:0000075)1.76849683
82Short nail (HP:0001799)1.76619068
83Ureteral stenosis (HP:0000071)1.75912557
84Wide anterior fontanel (HP:0000260)1.74472919
85Gastrointestinal atresia (HP:0002589)1.74139572
86Arnold-Chiari malformation (HP:0002308)1.74006187
87Labial hypoplasia (HP:0000066)1.73267723
88Mixed hearing impairment (HP:0000410)1.73128796
89Shawl scrotum (HP:0000049)1.72477972
90Short middle phalanx of finger (HP:0005819)1.72272944
91Broad phalanx (HP:0006009)1.72047051
92Abnormality of incisor morphology (HP:0011063)1.71003445
93Blepharitis (HP:0000498)1.70138001
94Palmoplantar hyperkeratosis (HP:0000972)1.70089048
95Trigonocephaly (HP:0000243)1.69463176
96Ureteral obstruction (HP:0006000)1.69345336
97Turricephaly (HP:0000262)1.69276057
98Aqueductal stenosis (HP:0002410)1.69256471
99Abnormality of the lacrimal duct (HP:0011481)1.68966885
100Palmar hyperkeratosis (HP:0010765)1.68331066
101Abnormality of the parietal bone (HP:0002696)1.68311463
102Increased nuchal translucency (HP:0010880)1.67773130
103Ulnar bowing (HP:0003031)1.67398206
104Germ cell neoplasia (HP:0100728)1.67048815
105Volvulus (HP:0002580)1.66361277
106Abnormality of the aortic arch (HP:0012303)1.66066637
107Abnormal hair laboratory examination (HP:0003328)1.64840530
108Bilateral microphthalmos (HP:0007633)1.64360033
109Ectopic anus (HP:0004397)1.63758112
110Abnormality of nail color (HP:0100643)1.63301165
111Arterial tortuosity (HP:0005116)1.63121559
112Abnormal pancreas size (HP:0012094)1.62888566
113Abnormality of dentin (HP:0010299)1.62703521
114Deviation of the thumb (HP:0009603)1.62625946
115Cortical dysplasia (HP:0002539)1.62489371
116Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.61576159
117Colon cancer (HP:0003003)1.61274603
118Broad toe (HP:0001837)1.60846516
119Neonatal short-limb short stature (HP:0008921)1.60680332
120Hypoplastic female external genitalia (HP:0012815)1.60525524
121Absent hair (HP:0002298)1.60296531
122Tarsal synostosis (HP:0008368)1.59778308
123Abnormal lung lobation (HP:0002101)1.59150926
124Humeroradial synostosis (HP:0003041)1.58926532
125Synostosis involving the elbow (HP:0003938)1.58926532
126Broad phalanges of the hand (HP:0009768)1.57833035
127Abnormality of permanent molar morphology (HP:0011071)1.56931847
128Abnormality of the dental root (HP:0006486)1.56931847
129Taurodontia (HP:0000679)1.56931847
130Abnormality of the nasolacrimal system (HP:0000614)1.56892698
131Abnormality of molar morphology (HP:0011070)1.56004053
132Abnormality of molar (HP:0011077)1.56004053
133Subacute progressive viral hepatitis (HP:0006572)1.55773651
134Facial cleft (HP:0002006)1.55265470
135Broad metatarsal (HP:0001783)1.54372178
136Abnormality of the distal phalanges of the toes (HP:0010182)1.54161898
137Gastrointestinal carcinoma (HP:0002672)1.53984591
138Malignant gastrointestinal tract tumors (HP:0006749)1.53984591
139Absent radius (HP:0003974)1.53868373
140Vertebral clefting (HP:0008428)1.53495158
141Mitral valve prolapse (HP:0001634)1.52872838
142Cupped ear (HP:0000378)1.52802080
143Choanal stenosis (HP:0000452)1.52294795
144Vaginal atresia (HP:0000148)1.52028259
145Oligodactyly (HP:0012165)1.51945890
146Anophthalmia (HP:0000528)1.51945074
147Broad finger (HP:0001500)1.51359797
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.51122300
149Osteolytic defects of the hand bones (HP:0009699)1.51122300
150Genital tract atresia (HP:0001827)1.50811802
151Abnormality of the 2nd finger (HP:0004100)1.50726633
152Tracheomalacia (HP:0002779)1.48645016
153Abnormality of the dental pulp (HP:0006479)1.48065115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.85793814
2LATS14.84209255
3EPHB22.87695083
4CDK122.73786837
5CASK2.72765102
6AKT32.58868344
7PNCK2.41908745
8FER2.20921078
9MKNK22.12554162
10OBSCN2.09145870
11TTN2.08135241
12PTK62.06980037
13STK38L2.06408395
14FGFR21.98709949
15PDGFRA1.96478702
16PTK21.93856340
17MST41.92904993
18DDR21.89135194
19RPS6KB21.87329829
20STK101.85676659
21TNIK1.79393508
22STK31.79230566
23LATS21.68609002
24PAK41.66548345
25TAF11.66338082
26PBK1.65983060
27MAP3K91.64477543
28TRIB31.59418914
29FGFR11.58263234
30FLT31.55423369
31LRRK21.53037955
32EEF2K1.52332932
33EPHA41.46126230
34DYRK1B1.45845163
35ERBB31.43493014
36PLK41.38900013
37MET1.28784498
38MELK1.26541860
39WNK41.26421553
40EPHA31.26130847
41ERBB21.20666321
42MAP3K41.20388271
43BCR1.19386533
44CDK61.16969314
45NTRK11.15350334
46SIK11.12722844
47EPHB11.12036619
48* MTOR1.10928829
49MAP3K21.04889570
50CDC71.04569618
51RIPK11.03506221
52NUAK11.00733052
53PRKD30.99815289
54TYRO30.99772134
55FGFR40.98647430
56FRK0.97971805
57SGK20.96771931
58NEK20.96733718
59DMPK0.94049519
60TRIM280.93233281
61PDGFRB0.92880049
62ICK0.92730514
63FGFR30.90375497
64STK240.89642533
65TTK0.89001120
66PRKCI0.88661573
67MST1R0.87133910
68PAK20.86010657
69BRSK20.85853820
70MARK10.84578147
71WNK30.84135939
72PAK30.83578937
73SRPK10.83388759
74ERBB40.80372989
75PLK20.80116558
76BMPR1B0.79958119
77CHUK0.78376326
78TRPM70.78178533
79DYRK30.76507438
80SGK4940.76319584
81SGK2230.76319584
82PASK0.75113394
83CSNK1G10.75110828
84AURKB0.75047610
85TGFBR10.74977911
86NEK90.74423991
87WEE10.72866200
88STK390.72045285
89MAP3K80.71745596
90PLK30.71279517
91SGK30.70535237
92RPS6KA40.69859853
93LMTK20.69834118
94PKN20.69473714
95MAPKAPK30.68358857
96BRD40.68078248
97CDK70.67959310
98MAP3K100.66944901
99BMX0.66339299
100NTRK20.65700765
101MKNK10.64521218
102CDK80.62882343
103CDC42BPA0.62505490
104TGFBR20.61789038
105CAMK1D0.60729442
106MAP2K20.57368600
107MAP3K70.57222962
108NLK0.56792222
109TESK10.56327623
110CHEK10.56315818
111KSR10.56139313
112MAP3K30.55183348
113CDK90.55102433
114TSSK60.54941794
115CSNK1A1L0.54214267
116CAMK1G0.54098165
117ROCK10.53680258
118CHEK20.52849865
119ROCK20.51689327
120NEK10.51376848
121AKT20.49979146
122CDK40.49069849
123WNK10.49013139
124ATM0.47215124
125GSK3A0.45940338
126RPS6KB10.45918269
127CDK30.45719640
128CSNK1E0.43218448
129BUB10.42809889
130BRAF0.42552893
131ACVR1B0.41981008
132RET0.41977916
133ATR0.41907677
134ILK0.41449827
135CSNK1D0.40646251
136PIK3CA0.39185928
137STK380.38832817
138PLK10.38816888
139PRKDC0.38601194
140PRKCE0.37453972
141CDK10.37443482
142MYLK0.35928992
143CDK20.34771848
144CSNK1G20.33638106

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.49835617
2Hippo signaling pathway_Homo sapiens_hsa043903.18648554
3ECM-receptor interaction_Homo sapiens_hsa045123.09712410
4Adherens junction_Homo sapiens_hsa045203.00644603
5Hedgehog signaling pathway_Homo sapiens_hsa043402.83582468
6Small cell lung cancer_Homo sapiens_hsa052222.66289668
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.42016812
8Tight junction_Homo sapiens_hsa045302.24549661
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.17702956
10Focal adhesion_Homo sapiens_hsa045102.11831510
11Proteoglycans in cancer_Homo sapiens_hsa052052.09963141
12MicroRNAs in cancer_Homo sapiens_hsa052062.03658212
13TGF-beta signaling pathway_Homo sapiens_hsa043501.93285449
14Non-homologous end-joining_Homo sapiens_hsa034501.80245191
15Wnt signaling pathway_Homo sapiens_hsa043101.78582123
16Bladder cancer_Homo sapiens_hsa052191.77668164
17Endometrial cancer_Homo sapiens_hsa052131.58254898
18p53 signaling pathway_Homo sapiens_hsa041151.54729288
19Notch signaling pathway_Homo sapiens_hsa043301.53465785
20Cell cycle_Homo sapiens_hsa041101.51814951
21Pathways in cancer_Homo sapiens_hsa052001.51758049
22Thyroid cancer_Homo sapiens_hsa052161.48704213
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48460629
24Protein digestion and absorption_Homo sapiens_hsa049741.44722257
25Axon guidance_Homo sapiens_hsa043601.42227716
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.41498507
27Amoebiasis_Homo sapiens_hsa051461.39352179
28Prostate cancer_Homo sapiens_hsa052151.39240707
29Melanogenesis_Homo sapiens_hsa049161.36061616
30Viral myocarditis_Homo sapiens_hsa054161.30183233
31Chronic myeloid leukemia_Homo sapiens_hsa052201.30132597
32Steroid biosynthesis_Homo sapiens_hsa001001.29667520
33Pancreatic cancer_Homo sapiens_hsa052121.27052398
34HTLV-I infection_Homo sapiens_hsa051661.25667762
35Melanoma_Homo sapiens_hsa052181.24273393
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23033686
37Propanoate metabolism_Homo sapiens_hsa006401.23023362
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22433386
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22312321
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21422262
41Colorectal cancer_Homo sapiens_hsa052101.20159845
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18768195
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16009846
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11830332
45Dilated cardiomyopathy_Homo sapiens_hsa054141.10929227
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09709929
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08904137
48Dorso-ventral axis formation_Homo sapiens_hsa043201.08182032
49Toxoplasmosis_Homo sapiens_hsa051451.05341194
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02229568
51Basal transcription factors_Homo sapiens_hsa030221.01353322
52Fanconi anemia pathway_Homo sapiens_hsa034600.97817331
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97804489
54Rap1 signaling pathway_Homo sapiens_hsa040150.96446004
55mRNA surveillance pathway_Homo sapiens_hsa030150.94530377
56Mismatch repair_Homo sapiens_hsa034300.93151579
57Renal cell carcinoma_Homo sapiens_hsa052110.92324985
58RNA transport_Homo sapiens_hsa030130.92153396
59Viral carcinogenesis_Homo sapiens_hsa052030.86724550
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85900281
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85505757
62mTOR signaling pathway_Homo sapiens_hsa041500.84299247
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80195319
64Lysine degradation_Homo sapiens_hsa003100.79731650
65Glioma_Homo sapiens_hsa052140.79725825
66FoxO signaling pathway_Homo sapiens_hsa040680.79287263
67Selenocompound metabolism_Homo sapiens_hsa004500.76114496
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72886611
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71231673
70Non-small cell lung cancer_Homo sapiens_hsa052230.69926146
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66447933
72Mineral absorption_Homo sapiens_hsa049780.66415749
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65801356
74Alcoholism_Homo sapiens_hsa050340.65795415
75Nucleotide excision repair_Homo sapiens_hsa034200.64465813
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63068786
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.60618451
78Vitamin B6 metabolism_Homo sapiens_hsa007500.59802013
79ErbB signaling pathway_Homo sapiens_hsa040120.59634531
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58264600
81Spliceosome_Homo sapiens_hsa030400.57240070
82Pyruvate metabolism_Homo sapiens_hsa006200.56661402
83Prolactin signaling pathway_Homo sapiens_hsa049170.56531971
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56087863
85Oocyte meiosis_Homo sapiens_hsa041140.55934635
86Estrogen signaling pathway_Homo sapiens_hsa049150.55188712
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.55004296
88RNA degradation_Homo sapiens_hsa030180.54108985
89One carbon pool by folate_Homo sapiens_hsa006700.54106092
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52068770
91Long-term depression_Homo sapiens_hsa047300.51614604
92Fatty acid biosynthesis_Homo sapiens_hsa000610.51464024
93Antigen processing and presentation_Homo sapiens_hsa046120.51428751
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51400721
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51112533
96Ras signaling pathway_Homo sapiens_hsa040140.51030903
97cAMP signaling pathway_Homo sapiens_hsa040240.50873085
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.50492677
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48388110
100DNA replication_Homo sapiens_hsa030300.48019277
101VEGF signaling pathway_Homo sapiens_hsa043700.47650624
102Taste transduction_Homo sapiens_hsa047420.47365106
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.45468804
104Glutamatergic synapse_Homo sapiens_hsa047240.45240565
105Glucagon signaling pathway_Homo sapiens_hsa049220.44405335
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44234787
107Glycerolipid metabolism_Homo sapiens_hsa005610.43683371
108Endocytosis_Homo sapiens_hsa041440.43284860
109Ovarian steroidogenesis_Homo sapiens_hsa049130.43136208
110Thyroid hormone synthesis_Homo sapiens_hsa049180.42902031
111beta-Alanine metabolism_Homo sapiens_hsa004100.42713854
112Dopaminergic synapse_Homo sapiens_hsa047280.42545800
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42518782
114TNF signaling pathway_Homo sapiens_hsa046680.42228329
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41729133
116AMPK signaling pathway_Homo sapiens_hsa041520.41390889
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.40230064
118Hepatitis C_Homo sapiens_hsa051600.39557157
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39535689
120Insulin resistance_Homo sapiens_hsa049310.39333561
121Choline metabolism in cancer_Homo sapiens_hsa052310.38542430
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.37646658
123Hepatitis B_Homo sapiens_hsa051610.37032827
124Inositol phosphate metabolism_Homo sapiens_hsa005620.35344925
125Gap junction_Homo sapiens_hsa045400.34767372
126Circadian rhythm_Homo sapiens_hsa047100.34274789
127Vitamin digestion and absorption_Homo sapiens_hsa049770.33065946
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32106530
129GnRH signaling pathway_Homo sapiens_hsa049120.31995358
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.31894681
131MAPK signaling pathway_Homo sapiens_hsa040100.31672548
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30777642
133Linoleic acid metabolism_Homo sapiens_hsa005910.29181273
134HIF-1 signaling pathway_Homo sapiens_hsa040660.28816559
135Ether lipid metabolism_Homo sapiens_hsa005650.26800644
136Acute myeloid leukemia_Homo sapiens_hsa052210.26004988

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