PTPN14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.97017946
2hippo signaling (GO:0035329)4.27689642
3glomerular basement membrane development (GO:0032836)4.15992180
4paraxial mesoderm development (GO:0048339)4.14528563
5desmosome organization (GO:0002934)4.11180271
6regulation of hippo signaling (GO:0035330)4.05256969
7polarized epithelial cell differentiation (GO:0030859)3.99435767
8chondrocyte proliferation (GO:0035988)3.93857915
9glomerular visceral epithelial cell development (GO:0072015)3.89790142
10epithelial cell-cell adhesion (GO:0090136)3.87593373
11cell-substrate junction assembly (GO:0007044)3.81266716
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76695347
13protein heterotrimerization (GO:0070208)3.73132415
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.63567199
15collagen fibril organization (GO:0030199)3.62354355
16endodermal cell differentiation (GO:0035987)3.61909771
17plasma membrane repair (GO:0001778)3.60602937
18establishment of apical/basal cell polarity (GO:0035089)3.54401220
19renal filtration (GO:0097205)3.52762927
20glomerular epithelial cell development (GO:0072310)3.51288813
21basement membrane organization (GO:0071711)3.50834373
22regulation of gene silencing by RNA (GO:0060966)3.48591059
23regulation of posttranscriptional gene silencing (GO:0060147)3.48591059
24regulation of gene silencing by miRNA (GO:0060964)3.48591059
25wound healing, spreading of epidermal cells (GO:0035313)3.48492163
26axon extension involved in axon guidance (GO:0048846)3.47957251
27neuron projection extension involved in neuron projection guidance (GO:1902284)3.47957251
28negative regulation of keratinocyte proliferation (GO:0010839)3.35507214
29vascular endothelial growth factor signaling pathway (GO:0038084)3.33416771
30adherens junction assembly (GO:0034333)3.30314648
31cell adhesion mediated by integrin (GO:0033627)3.25147141
32pericardium development (GO:0060039)3.24677683
33branching involved in salivary gland morphogenesis (GO:0060445)3.22586476
34cell migration involved in sprouting angiogenesis (GO:0002042)3.19790686
35regulation of SMAD protein import into nucleus (GO:0060390)3.19076075
36regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.15191119
37positive regulation of endothelial cell apoptotic process (GO:2000353)3.14659961
38skin morphogenesis (GO:0043589)3.14166277
39artery development (GO:0060840)3.12689031
40substrate-dependent cell migration (GO:0006929)3.11751377
41regulation of transforming growth factor beta2 production (GO:0032909)3.11749289
42positive regulation of osteoblast proliferation (GO:0033690)3.09271773
43bone trabecula formation (GO:0060346)3.07419477
44negative regulation of cell fate specification (GO:0009996)3.04606227
45mesodermal cell differentiation (GO:0048333)3.03812420
46negative regulation of chondrocyte differentiation (GO:0032331)3.02902825
47outer ear morphogenesis (GO:0042473)3.02192417
48positive regulation of SMAD protein import into nucleus (GO:0060391)3.01366833
49negative regulation of axon extension involved in axon guidance (GO:0048843)2.97769494
50sequestering of extracellular ligand from receptor (GO:0035581)2.97013152
51cell-substrate adherens junction assembly (GO:0007045)2.96539225
52focal adhesion assembly (GO:0048041)2.96539225
53retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96507963
54G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92228978
55establishment or maintenance of monopolar cell polarity (GO:0061339)2.89680135
56establishment of monopolar cell polarity (GO:0061162)2.89680135
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.87821944
58insulin-like growth factor receptor signaling pathway (GO:0048009)2.86269078
59embryonic camera-type eye development (GO:0031076)2.85129757
60substrate adhesion-dependent cell spreading (GO:0034446)2.84074586
61smooth muscle tissue development (GO:0048745)2.82377276
62regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80803533
63regulation of cell fate specification (GO:0042659)2.79745130
64notochord development (GO:0030903)2.79214446
65glomerular filtration (GO:0003094)2.79000565
66endocardial cushion development (GO:0003197)2.77577202
67positive regulation of epithelial to mesenchymal transition (GO:0010718)2.77214987
68wound healing, spreading of cells (GO:0044319)2.76885972
69nuclear pore organization (GO:0006999)2.75871873
70UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74872542
71mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74773438
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.74714237
73regulation of tight junction assembly (GO:2000810)2.72550847
74negative regulation of fatty acid transport (GO:2000192)2.72318905
75lung-associated mesenchyme development (GO:0060484)2.69400639
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.68948079
77cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68011181
78atrioventricular valve morphogenesis (GO:0003181)2.67035964
79regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.66095657
80negative regulation of cartilage development (GO:0061037)2.65250741
81non-canonical Wnt signaling pathway (GO:0035567)2.63373552
82bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62682225
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61681481
84regulation of heart morphogenesis (GO:2000826)2.61373080
85apoptotic process involved in morphogenesis (GO:0060561)2.60650279
86blood vessel endothelial cell migration (GO:0043534)2.60387872
87metanephric mesenchyme development (GO:0072075)2.59003168
88negative regulation of catenin import into nucleus (GO:0035414)2.58797831
89kidney mesenchyme development (GO:0072074)2.57653745
90protein localization to cell surface (GO:0034394)2.56575988
91ventricular septum development (GO:0003281)2.56574041
92Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.56246279
93endothelial cell morphogenesis (GO:0001886)2.55935806
94collecting duct development (GO:0072044)2.54797894
95craniofacial suture morphogenesis (GO:0097094)2.54580765
96gap junction assembly (GO:0016264)2.54129519
97muscle cell migration (GO:0014812)2.53742695
98regulation of establishment of planar polarity (GO:0090175)2.53492149
99embryonic foregut morphogenesis (GO:0048617)2.52513465
100heterochromatin organization (GO:0070828)2.52502215
101mesenchyme development (GO:0060485)2.52186282
102negative regulation of stem cell proliferation (GO:2000647)2.51907557
103* lymphangiogenesis (GO:0001946)2.49044722
104regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.48827124
105cellular response to vitamin (GO:0071295)2.47999895
106regulation of catenin import into nucleus (GO:0035412)2.47865651
107cell surface receptor signaling pathway involved in heart development (GO:0061311)2.46193049
108collagen metabolic process (GO:0032963)2.45964605
109positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45180506
110lateral sprouting from an epithelium (GO:0060601)2.45131447
111mammary gland development (GO:0030879)2.45032391
112extracellular matrix disassembly (GO:0022617)2.44542756
113regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.43707792
114neural crest cell development (GO:0014032)2.43605647
115dorsal/ventral axis specification (GO:0009950)2.43245242
116regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.42478449
117mesenchymal-epithelial cell signaling (GO:0060638)2.42477363
118cell migration involved in heart development (GO:0060973)2.41705648
119lymph vessel development (GO:0001945)2.41638695
120cellular response to vitamin D (GO:0071305)2.41322520
121anterior/posterior axis specification, embryo (GO:0008595)2.41249169
122axis elongation (GO:0003401)2.40653015
123positive regulation of mesenchymal cell proliferation (GO:0002053)2.40246911
124nuclear pore complex assembly (GO:0051292)2.40123831
125regulation of keratinocyte proliferation (GO:0010837)2.40101514
126embryonic cranial skeleton morphogenesis (GO:0048701)2.39357929
127regulation of cardioblast differentiation (GO:0051890)2.39301222
128negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.38653482
129regulation of integrin-mediated signaling pathway (GO:2001044)2.38398504
130establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38301674
131regulation of osteoblast proliferation (GO:0033688)2.37453413
132sprouting angiogenesis (GO:0002040)2.36866243
133regulation of axon extension involved in axon guidance (GO:0048841)2.34944384
134heparan sulfate proteoglycan metabolic process (GO:0030201)2.34683061
135ventricular cardiac muscle cell development (GO:0055015)2.34516284
136negative regulation of cardiac muscle tissue development (GO:0055026)2.33665849
137negative regulation of BMP signaling pathway (GO:0030514)2.32712375
138mitotic cytokinesis (GO:0000281)2.32600571
139negative regulation of DNA repair (GO:0045738)2.32148627
140keratinocyte proliferation (GO:0043616)2.29809724
141cell junction assembly (GO:0034329)2.27835032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.61892692
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.85304753
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39901670
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.28251629
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.19545285
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.03005694
7CLOCK_20551151_ChIP-Seq_293T_Human2.66684612
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.58883474
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.50829224
10E2F7_22180533_ChIP-Seq_HELA_Human2.35107336
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.34620056
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28228158
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24656304
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.23492027
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21590627
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14966803
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.10762923
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05626008
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90885557
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.90856339
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.90856339
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.88892489
23ZNF263_19887448_ChIP-Seq_K562_Human1.88531481
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88496864
25* TP53_18474530_ChIP-ChIP_U2OS_Human1.87152730
26* TP53_16413492_ChIP-PET_HCT116_Human1.86963940
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86796720
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.85116248
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84673598
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83951698
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.82784015
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79508426
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76866542
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74665006
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72950452
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72950452
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72950452
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.72252184
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.66237678
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64521986
41* ATF3_27146783_Chip-Seq_COLON_Human1.63759843
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62630139
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61902440
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61444749
45AR_21909140_ChIP-Seq_LNCAP_Human1.61178312
46* GBX2_23144817_ChIP-Seq_PC3_Human1.61143818
47AHR_22903824_ChIP-Seq_MCF-7_Human1.60704815
48* FOXO3_23340844_ChIP-Seq_DLD1_Human1.60218859
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59953399
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59577907
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.59099108
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54782935
53CJUN_26792858_Chip-Seq_BT549_Human1.52529819
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52411969
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50785346
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.50729733
57* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49832727
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48586189
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48586189
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48401264
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.47636680
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47543355
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.47160621
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46376782
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.45426368
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44992432
67RACK7_27058665_Chip-Seq_MCF-7_Human1.44719765
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.43729393
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.43720269
70* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41721165
71* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40722097
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.40240636
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39740056
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36883502
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36327393
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34363571
77* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31072989
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29611582
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29454919
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29320164
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27620146
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27549279
83* TP53_22127205_ChIP-Seq_IMR90_Human1.25251082
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24591673
85* TP63_23658742_ChIP-Seq_EP156T_Human1.24138651
86* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23786203
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23559410
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23400367
89* TBX20_22328084_ChIP-Seq_HEART_Mouse1.23047119
90* TBX20_22080862_ChIP-Seq_HEART_Mouse1.23047119
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.23013465
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22576566
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22197323
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21991001
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21257527
96* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21176565
97* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21092336
98KDM2B_26808549_Chip-Seq_DND41_Human1.20946684
99* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20458512
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.18875322
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18832338
102* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18296765
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18151811
104MYC_22102868_ChIP-Seq_BL_Human1.17062468
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16865616
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16499597
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15881202
108MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15470134
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13718622
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13264062
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13140839
112* SMAD4_21799915_ChIP-Seq_A2780_Human1.13054170
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12852971
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12410616
115* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11859252
116* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11651884
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.10914199
118* TP53_23651856_ChIP-Seq_MEFs_Mouse1.10457252
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10034037
120ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09541192
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09086879
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08402400
123TCF7_22412390_ChIP-Seq_EML_Mouse1.08097841
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07383097
125ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07053092
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07019765
127CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06721754
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.06509446
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04756057
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.03171022
131FUS_26573619_Chip-Seq_HEK293_Human1.03134598
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02969672
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02290954
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.02094313
135KDM2B_26808549_Chip-Seq_JURKAT_Human1.01827473
136ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00601708
137MYC_18555785_ChIP-Seq_MESCs_Mouse1.00087841
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99676285
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99008372
140STAT3_23295773_ChIP-Seq_U87_Human0.93517974
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93302761
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92504692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.13873655
2MP0005275_abnormal_skin_tensile3.79255967
3MP0003705_abnormal_hypodermis_morpholog3.76845207
4MP0003950_abnormal_plasma_membrane3.30747212
5MP0004272_abnormal_basement_membrane3.08549503
6MP0005623_abnormal_meninges_morphology2.86783989
7MP0003941_abnormal_skin_development2.75412026
8MP0010352_gastrointestinal_tract_polyps2.62992824
9MP0010030_abnormal_orbit_morphology2.51877933
10MP0005503_abnormal_tendon_morphology2.41096060
11MP0003566_abnormal_cell_adhesion2.37570261
12MP0000537_abnormal_urethra_morphology2.18059658
13MP0010234_abnormal_vibrissa_follicle2.17274383
14MP0003279_aneurysm2.00841334
15MP0002060_abnormal_skin_morphology1.92568241
16MP0009053_abnormal_anal_canal1.89069302
17MP0002796_impaired_skin_barrier1.84722581
18MP0009384_cardiac_valve_regurgitation1.72052770
19MP0000733_abnormal_muscle_development1.71895666
20MP0005076_abnormal_cell_differentiation1.71513467
21MP0009780_abnormal_chondrocyte_physiolo1.70983900
22MP0005023_abnormal_wound_healing1.69381769
23MP0001958_emphysema1.65874131
24MP0003385_abnormal_body_wall1.59948097
25MP0000013_abnormal_adipose_tissue1.55428439
26MP0003091_abnormal_cell_migration1.52051657
27MP0005508_abnormal_skeleton_morphology1.50548795
28MP0010368_abnormal_lymphatic_system1.47152021
29MP0005501_abnormal_skin_physiology1.42418039
30MP0001849_ear_inflammation1.42231815
31MP0002254_reproductive_system_inflammat1.41602533
32MP0002877_abnormal_melanocyte_morpholog1.41425235
33MP0003942_abnormal_urinary_system1.37285498
34MP0006054_spinal_hemorrhage1.36327517
35MP0000534_abnormal_ureter_morphology1.34771404
36MP0000749_muscle_degeneration1.34693105
37MP0000762_abnormal_tongue_morphology1.30604120
38MP0010678_abnormal_skin_adnexa1.29824782
39MP0000428_abnormal_craniofacial_morphol1.29753913
40MP0004185_abnormal_adipocyte_glucose1.29616910
41MP0004084_abnormal_cardiac_muscle1.28646818
42MP0000383_abnormal_hair_follicle1.28397423
43MP0009250_abnormal_appendicular_skeleto1.27120714
44MP0005409_darkened_coat_color1.26969721
45MP0003453_abnormal_keratinocyte_physiol1.25243286
46MP0005367_renal/urinary_system_phenotyp1.24006105
47MP0000516_abnormal_urinary_system1.24006105
48MP0005171_absent_coat_pigmentation1.22441843
49MP0000750_abnormal_muscle_regeneration1.21560266
50MP0003937_abnormal_limbs/digits/tail_de1.21215485
51MP0004197_abnormal_fetal_growth/weight/1.20629588
52MP0003115_abnormal_respiratory_system1.19158494
53MP0003283_abnormal_digestive_organ1.18799788
54MP0000767_abnormal_smooth_muscle1.15201667
55MP0003935_abnormal_craniofacial_develop1.14420130
56MP0002282_abnormal_trachea_morphology1.13705740
57MP0002932_abnormal_joint_morphology1.12271662
58MP0003755_abnormal_palate_morphology1.11022922
59MP0002697_abnormal_eye_size1.10322129
60MP0000432_abnormal_head_morphology1.09733400
61MP0005257_abnormal_intraocular_pressure1.09649259
62MP0002108_abnormal_muscle_morphology1.09518287
63MP0002084_abnormal_developmental_patter1.09395026
64MP0000467_abnormal_esophagus_morphology1.08248294
65MP0001879_abnormal_lymphatic_vessel1.07664232
66MP0002111_abnormal_tail_morphology1.07275879
67MP0006138_congestive_heart_failure1.06833582
68MP0002925_abnormal_cardiovascular_devel1.06331649
69MP0002896_abnormal_bone_mineralization1.06231447
70MP0010630_abnormal_cardiac_muscle1.05311364
71MP0003828_pulmonary_edema1.01806903
72MP0001661_extended_life_span1.01755284
73MP0002249_abnormal_larynx_morphology1.01679581
74MP0001299_abnormal_eye_distance/1.00584920
75MP0002234_abnormal_pharynx_morphology1.00516188
76MP0003567_abnormal_fetal_cardiomyocyte0.99966151
77MP0005197_abnormal_uvea_morphology0.99406645
78MP0001216_abnormal_epidermal_layer0.95585553
79MP0004087_abnormal_muscle_fiber0.95499898
80MP0001243_abnormal_dermal_layer0.95100743
81MP0005595_abnormal_vascular_smooth0.95073839
82MP0003045_fibrosis0.94910977
83MP0002233_abnormal_nose_morphology0.93973485
84MP0002085_abnormal_embryonic_tissue0.93833494
85MP0000569_abnormal_digit_pigmentation0.93312502
86MP0010771_integument_phenotype0.92939923
87MP0001348_abnormal_lacrimal_gland0.92910057
88MP0004233_abnormal_muscle_weight0.92732529
89MP0002088_abnormal_embryonic_growth/wei0.91992326
90MP0002086_abnormal_extraembryonic_tissu0.91991258
91MP0002092_abnormal_eye_morphology0.91743814
92MP0003984_embryonic_growth_retardation0.91232406
93MP0000427_abnormal_hair_cycle0.90997175
94MP0002098_abnormal_vibrissa_morphology0.90755856
95MP0005666_abnormal_adipose_tissue0.90136719
96MP0001915_intracranial_hemorrhage0.88929904
97MP0001672_abnormal_embryogenesis/_devel0.88614979
98MP0005380_embryogenesis_phenotype0.88614979
99MP0003119_abnormal_digestive_system0.88533843
100MP0000759_abnormal_skeletal_muscle0.87927203
101MP0000579_abnormal_nail_morphology0.87664345
102MP0000163_abnormal_cartilage_morphology0.86670336
103MP0001293_anophthalmia0.86329751
104MP0000751_myopathy0.86203671
105MP0001614_abnormal_blood_vessel0.85594336
106MP0002177_abnormal_outer_ear0.85302538
107MP0005375_adipose_tissue_phenotype0.84876706
108MP0002295_abnormal_pulmonary_circulatio0.84120045
109MP0000377_abnormal_hair_follicle0.83805107
110MP0002128_abnormal_blood_circulation0.81731884
111MP0003890_abnormal_embryonic-extraembry0.81725776
112MP0009278_abnormal_bone_marrow0.81535898
113MP0001697_abnormal_embryo_size0.80891102
114MP0000049_abnormal_middle_ear0.80849971
115MP0000003_abnormal_adipose_tissue0.79885034
116MP0002116_abnormal_craniofacial_bone0.79680131
117MP0002269_muscular_atrophy0.79610771
118MP0009697_abnormal_copulation0.79236794
119MP0008932_abnormal_embryonic_tissue0.79217486
120MP0004134_abnormal_chest_morphology0.77264052
121MP0001542_abnormal_bone_strength0.76215961
122MP0002938_white_spotting0.75245874
123MP0001286_abnormal_eye_development0.74215149
124MP0000627_abnormal_mammary_gland0.74113286
125MP0005620_abnormal_muscle_contractility0.73710067
126MP0004036_abnormal_muscle_relaxation0.73618714
127MP0004858_abnormal_nervous_system0.73135673

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.49914935
2Premature rupture of membranes (HP:0001788)4.84625289
3Shallow orbits (HP:0000586)4.31704513
4Atrophic scars (HP:0001075)4.01896007
5Ankle contracture (HP:0006466)3.91400958
6Cerebral aneurysm (HP:0004944)3.37518477
7Broad metatarsal (HP:0001783)3.23858803
8Increased connective tissue (HP:0009025)3.17442102
9Arterial tortuosity (HP:0005116)3.11877817
10Right ventricular cardiomyopathy (HP:0011663)3.09743181
11Cervical subluxation (HP:0003308)3.06545878
12Aortic dissection (HP:0002647)2.98218415
13Fragile skin (HP:0001030)2.94443420
14Aortic aneurysm (HP:0004942)2.82101919
15Soft skin (HP:0000977)2.61926046
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61589549
17Short 4th metacarpal (HP:0010044)2.61589549
18Mitral valve prolapse (HP:0001634)2.55725761
19Bladder diverticulum (HP:0000015)2.53795529
20Dilatation of the ascending aorta (HP:0005111)2.53483173
21Genu recurvatum (HP:0002816)2.53224531
22Spinal rigidity (HP:0003306)2.50989505
23Milia (HP:0001056)2.49689078
24Wrist flexion contracture (HP:0001239)2.45087214
25Neonatal short-limb short stature (HP:0008921)2.36702182
26Type 1 muscle fiber predominance (HP:0003803)2.36059527
27Hyporeflexia of lower limbs (HP:0002600)2.34933834
28Selective tooth agenesis (HP:0001592)2.34780549
29Ulnar bowing (HP:0003031)2.31367367
30Wormian bones (HP:0002645)2.22003047
31Abnormality of the 4th metacarpal (HP:0010012)2.17530633
32Aneurysm (HP:0002617)2.16536184
33Blue sclerae (HP:0000592)2.15433157
34Peritonitis (HP:0002586)2.14975762
35Abnormality of dentin (HP:0010299)2.11963358
36Radial bowing (HP:0002986)2.10450284
37Cardiovascular calcification (HP:0011915)2.09359201
38Coronal craniosynostosis (HP:0004440)2.06434563
39Mesangial abnormality (HP:0001966)2.06392117
40Follicular hyperkeratosis (HP:0007502)2.06306161
41Difficulty climbing stairs (HP:0003551)2.03506534
42Muscle fiber splitting (HP:0003555)2.02993924
43Reduced subcutaneous adipose tissue (HP:0003758)2.00522767
44Scapular winging (HP:0003691)2.00289762
45Mesomelia (HP:0003027)1.99714601
46Mildly elevated creatine phosphokinase (HP:0008180)1.99386869
47Bowed forearm bones (HP:0003956)1.98301033
48Bowing of the arm (HP:0006488)1.98301033
49Camptodactyly of toe (HP:0001836)1.97400859
50Abnormality of the calcaneus (HP:0008364)1.95929197
51Bowel diverticulosis (HP:0005222)1.94383781
52Limited hip movement (HP:0008800)1.92893508
53Short hallux (HP:0010109)1.92803230
54Spondylolisthesis (HP:0003302)1.92754830
55Osteolytic defects of the phalanges of the hand (HP:0009771)1.92407273
56Osteolytic defects of the hand bones (HP:0009699)1.92407273
57Deviation of the hallux (HP:0010051)1.92262588
58Broad thumb (HP:0011304)1.89806117
59Rectal prolapse (HP:0002035)1.89114225
60Nemaline bodies (HP:0003798)1.89096481
61Natal tooth (HP:0000695)1.88693400
62Short nail (HP:0001799)1.88584367
63Abnormality of the nasal septum (HP:0000419)1.87967578
64Ventricular tachycardia (HP:0004756)1.87247283
65Morphological abnormality of the middle ear (HP:0008609)1.86917839
66Aortic regurgitation (HP:0001659)1.86652743
67Elbow flexion contracture (HP:0002987)1.86562034
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86518663
69Abnormality of the proximal phalanges of the hand (HP:0009834)1.86358841
70Wide anterior fontanel (HP:0000260)1.85031219
71Lymphangioma (HP:0100764)1.83643234
72Deviation of the thumb (HP:0009603)1.81203485
73Broad long bones (HP:0005622)1.81125180
74Advanced eruption of teeth (HP:0006288)1.80990403
75Hip contracture (HP:0003273)1.80941865
76Hallux valgus (HP:0001822)1.80924968
77Knee flexion contracture (HP:0006380)1.80903649
78Spinal cord lesions (HP:0100561)1.79133446
79Syringomyelia (HP:0003396)1.79133446
80Pterygium (HP:0001059)1.78747694
81Focal segmental glomerulosclerosis (HP:0000097)1.78547551
82Hyperextensible skin (HP:0000974)1.78348854
83Increased variability in muscle fiber diameter (HP:0003557)1.78219606
84Buphthalmos (HP:0000557)1.77531889
85Bronchomalacia (HP:0002780)1.77477219
86Abnormality of the acetabulum (HP:0003170)1.77277901
87Abnormality of the distal phalanx of the thumb (HP:0009617)1.76923138
88Fused cervical vertebrae (HP:0002949)1.76096229
89Onycholysis (HP:0001806)1.75944244
90Increased density of long bones (HP:0006392)1.75681389
91Mitral regurgitation (HP:0001653)1.73367239
92Abnormality of the distal phalanges of the toes (HP:0010182)1.71655381
93Muscle fiber inclusion bodies (HP:0100299)1.71301591
94Fragile nails (HP:0001808)1.70575276
95Round ear (HP:0100830)1.70291776
96Abnormal vertebral ossification (HP:0100569)1.70254681
97Distal lower limb amyotrophy (HP:0008944)1.69786873
98Distal upper limb amyotrophy (HP:0007149)1.69491724
99Upper limb amyotrophy (HP:0009129)1.69491724
100Synostosis of carpal bones (HP:0005048)1.69449929
101Asymmetry of the thorax (HP:0001555)1.69332696
102Joint laxity (HP:0001388)1.69020829
103Missing ribs (HP:0000921)1.68177539
104Aplasia/Hypoplasia of the hallux (HP:0008362)1.68044146
105Overgrowth (HP:0001548)1.67983956
106Vascular tortuosity (HP:0004948)1.67210905
107Difficulty running (HP:0009046)1.66954080
108Entropion (HP:0000621)1.66868304
109Absent frontal sinuses (HP:0002688)1.66185694
110Short humerus (HP:0005792)1.66084134
111Broad toe (HP:0001837)1.65614243
112Tibial bowing (HP:0002982)1.65068886
113Hypoplasia of the iris (HP:0007676)1.64347717
114Hypotrichosis (HP:0001006)1.64176178
115Broad phalanx (HP:0006009)1.64076765
116Distal lower limb muscle weakness (HP:0009053)1.63904114
117Aortic valve stenosis (HP:0001650)1.62870815
118Woolly hair (HP:0002224)1.61817266
119Broad face (HP:0000283)1.58528160
120Thick nail (HP:0001805)1.57799923
121Alopecia of scalp (HP:0002293)1.57007810
122Increased number of teeth (HP:0011069)1.56370246
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56277739
124Short 1st metacarpal (HP:0010034)1.56277739
125Long eyelashes (HP:0000527)1.55862109
126Abnormality of carpal bone ossification (HP:0006257)1.54973069
127Persistence of primary teeth (HP:0006335)1.54882938
128Hypoplastic labia majora (HP:0000059)1.54686687
129Preaxial foot polydactyly (HP:0001841)1.54498067
130Abnormal ossification of hand bones (HP:0005921)1.54046018
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.52652916
132Mitral stenosis (HP:0001718)1.50902037
133Bradycardia (HP:0001662)1.50694688
134Slender build (HP:0001533)1.48491847
135Abnormality of the labia majora (HP:0012881)1.46870039
136Vascular calcification (HP:0004934)1.45625555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.98805813
2LATS13.33337924
3TRIB33.18846438
4EPHA23.08310899
5DDR22.99027426
6CDK122.89072565
7PDGFRA2.62105721
8PKN22.56449626
9EEF2K2.39737814
10MYLK2.32694075
11EPHB22.28340907
12LATS22.20836924
13RIPK12.13451649
14SIK11.98541326
15ERBB41.97220501
16AKT31.85894027
17LRRK21.79702725
18RPS6KB21.78322387
19FER1.77217574
20PTK61.73547372
21NTRK11.68606125
22TGFBR11.66948666
23PAK41.64340543
24PAK21.64142131
25MTOR1.54793303
26PTK21.53886472
27STK31.53454240
28PBK1.52731350
29MAPKAPK31.49448388
30STK101.45086491
31MET1.44623102
32FGFR11.43526557
33DMPK1.42072701
34TGFBR21.41010901
35PNCK1.40095435
36BMX1.38191954
37MAP3K101.36976089
38STK381.36203239
39LIMK11.31987462
40ERN11.27738179
41FGFR21.24559251
42TRPM71.24070202
43TIE11.23754666
44CAMK1D1.20559909
45CDK61.18433336
46BRSK21.16943645
47MAP3K31.14815458
48PDGFRB1.12384853
49ICK1.11604120
50MST1R1.00214209
51STK38L0.98313645
52BMPR1B0.92532268
53CDK80.92221101
54TSSK60.91729819
55OBSCN0.88083481
56BUB10.87890579
57TAF10.87806847
58PAK30.86204033
59ILK0.84737543
60RPS6KA40.84320799
61MAP3K80.81823053
62BRD40.80432820
63ADRBK10.79761433
64NEK10.78571817
65MKNK20.76929851
66CDK70.76155500
67NEK20.75509783
68FGFR30.74703059
69ROCK10.73314435
70KDR0.72109519
71CAMK1G0.70898942
72TTK0.70501787
73PLK30.69785520
74CHEK20.65066986
75MAP2K30.64448340
76SCYL20.64158973
77EPHA30.63279644
78WEE10.62827211
79TYRO30.62353765
80MAP3K70.61420619
81FGFR40.60398012
82PIK3CA0.58964653
83PLK20.58610351
84FLT30.58203822
85DYRK1B0.56737349
86AURKB0.56439409
87MAP3K60.56199430
88PLK10.55796198
89CDK40.55588634
90AKT20.54832296
91ABL20.54792340
92FRK0.54267165
93PRKD10.53841264
94WNK30.53340783
95ALK0.52905510
96MAP2K10.52465658
97WNK10.52321675
98PASK0.51787406
99PRKCE0.51135636
100CDC70.49916418
101EPHB10.49694250
102TESK10.48669361
103NEK90.47609174
104INSR0.47180549
105ROCK20.47094292
106RPS6KA20.46822265
107CDK90.46183274
108MAPKAPK50.45471879
109CHUK0.44608903
110EIF2AK30.42387509
111ERBB20.41730023
112PRKG20.41603516
113PHKG20.39840099
114PHKG10.39840099
115EIF2AK20.39809999
116PIM20.39622146
117MOS0.39477958
118MAPKAPK20.38902241
119MAPK10.38274535
120PTK2B0.36607281
121SMG10.36258752
122MELK0.36019376
123RET0.35770370
124PDK20.35665176
125MUSK0.35439146
126CHEK10.35227627
127PRKAA20.35181480
128LMTK20.34777831
129GSK3A0.34668383
130PIK3CG0.34549147
131NUAK10.34289648
132PRKD20.33082611
133CDC42BPA0.32857352
134SRC0.32792703
135GRK10.32326458
136MAP2K20.31253728
137MARK20.30908211
138AKT10.28774579
139PDK30.28657933
140PDK40.28657933
141PAK10.28373517

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.64343398
2Adherens junction_Homo sapiens_hsa045202.84777653
3Basal cell carcinoma_Homo sapiens_hsa052172.75621479
4Focal adhesion_Homo sapiens_hsa045102.73984101
5Small cell lung cancer_Homo sapiens_hsa052222.66415397
6Hippo signaling pathway_Homo sapiens_hsa043902.54956520
7Proteoglycans in cancer_Homo sapiens_hsa052052.41492844
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.33411388
9Bladder cancer_Homo sapiens_hsa052192.19195298
10MicroRNAs in cancer_Homo sapiens_hsa052062.18014536
11Hedgehog signaling pathway_Homo sapiens_hsa043402.12791457
12p53 signaling pathway_Homo sapiens_hsa041151.93830390
13Amoebiasis_Homo sapiens_hsa051461.90407707
14TGF-beta signaling pathway_Homo sapiens_hsa043501.83547959
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.82490831
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.82060395
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80081557
18Tight junction_Homo sapiens_hsa045301.78351512
19Dilated cardiomyopathy_Homo sapiens_hsa054141.74843995
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.72850489
21Protein digestion and absorption_Homo sapiens_hsa049741.60672539
22Selenocompound metabolism_Homo sapiens_hsa004501.59888759
23Chronic myeloid leukemia_Homo sapiens_hsa052201.58191615
24Viral myocarditis_Homo sapiens_hsa054161.53555148
25Notch signaling pathway_Homo sapiens_hsa043301.50336854
26Pathways in cancer_Homo sapiens_hsa052001.44796575
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.44704772
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44089680
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41360566
30Melanoma_Homo sapiens_hsa052181.39454086
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34770219
32Wnt signaling pathway_Homo sapiens_hsa043101.32754506
33HTLV-I infection_Homo sapiens_hsa051661.31260162
34Thyroid cancer_Homo sapiens_hsa052161.30309237
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.28012898
36Prostate cancer_Homo sapiens_hsa052151.26262294
37Non-homologous end-joining_Homo sapiens_hsa034501.21693663
38Cell cycle_Homo sapiens_hsa041101.20912929
39Endometrial cancer_Homo sapiens_hsa052131.19389221
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.16133057
41Melanogenesis_Homo sapiens_hsa049161.13016015
42Rap1 signaling pathway_Homo sapiens_hsa040151.10084540
43mTOR signaling pathway_Homo sapiens_hsa041501.08572667
44Toxoplasmosis_Homo sapiens_hsa051451.04356572
45Colorectal cancer_Homo sapiens_hsa052101.01592644
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01248580
47Axon guidance_Homo sapiens_hsa043601.00661376
48Pancreatic cancer_Homo sapiens_hsa052121.00228154
49Glioma_Homo sapiens_hsa052140.98801194
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98639271
51Viral carcinogenesis_Homo sapiens_hsa052030.98103833
52Lysine degradation_Homo sapiens_hsa003100.93816604
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93655086
54Nucleotide excision repair_Homo sapiens_hsa034200.93262089
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93185942
56RNA transport_Homo sapiens_hsa030130.92937045
57Renal cell carcinoma_Homo sapiens_hsa052110.92163570
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90158759
59N-Glycan biosynthesis_Homo sapiens_hsa005100.90037752
60HIF-1 signaling pathway_Homo sapiens_hsa040660.88033495
61Circadian rhythm_Homo sapiens_hsa047100.84562635
62AMPK signaling pathway_Homo sapiens_hsa041520.81462890
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80336571
64Platelet activation_Homo sapiens_hsa046110.80181567
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.78968271
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.78640165
67Insulin resistance_Homo sapiens_hsa049310.78259475
68Dorso-ventral axis formation_Homo sapiens_hsa043200.78138535
69VEGF signaling pathway_Homo sapiens_hsa043700.75778911
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73988589
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73896039
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73667521
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72892882
74Acute myeloid leukemia_Homo sapiens_hsa052210.72660492
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72319360
76Fanconi anemia pathway_Homo sapiens_hsa034600.71510038
77FoxO signaling pathway_Homo sapiens_hsa040680.69209181
78Non-small cell lung cancer_Homo sapiens_hsa052230.69122771
79Apoptosis_Homo sapiens_hsa042100.68489911
80mRNA surveillance pathway_Homo sapiens_hsa030150.67837239
81Basal transcription factors_Homo sapiens_hsa030220.66179280
82Shigellosis_Homo sapiens_hsa051310.65422846
83One carbon pool by folate_Homo sapiens_hsa006700.65230095
84Estrogen signaling pathway_Homo sapiens_hsa049150.65169719
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63562631
86Malaria_Homo sapiens_hsa051440.61356085
87Insulin signaling pathway_Homo sapiens_hsa049100.60234814
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.57975650
89Hepatitis B_Homo sapiens_hsa051610.56549630
90Spliceosome_Homo sapiens_hsa030400.55743164
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55698248
92Ribosome_Homo sapiens_hsa030100.54954082
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.54285648
94Sulfur metabolism_Homo sapiens_hsa009200.54240125
95Vitamin B6 metabolism_Homo sapiens_hsa007500.54189768
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54011005
97Calcium signaling pathway_Homo sapiens_hsa040200.53456115
98TNF signaling pathway_Homo sapiens_hsa046680.53272352
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.52764724
100Gap junction_Homo sapiens_hsa045400.50584817
101Sphingolipid metabolism_Homo sapiens_hsa006000.50530094
102RNA polymerase_Homo sapiens_hsa030200.49370522
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49232523
104Ras signaling pathway_Homo sapiens_hsa040140.47356122
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47266210
106ErbB signaling pathway_Homo sapiens_hsa040120.46023097
107Renin-angiotensin system_Homo sapiens_hsa046140.45020476
108Pyruvate metabolism_Homo sapiens_hsa006200.44528511
109Salmonella infection_Homo sapiens_hsa051320.43864846
110Glucagon signaling pathway_Homo sapiens_hsa049220.43169073
111Endocytosis_Homo sapiens_hsa041440.42474639
112Homologous recombination_Homo sapiens_hsa034400.42426303
113MAPK signaling pathway_Homo sapiens_hsa040100.40230055
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39891886
115Ovarian steroidogenesis_Homo sapiens_hsa049130.38881973
116Thyroid hormone synthesis_Homo sapiens_hsa049180.38066650
117Fatty acid biosynthesis_Homo sapiens_hsa000610.36709023
118Antigen processing and presentation_Homo sapiens_hsa046120.35917822
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35818275
120DNA replication_Homo sapiens_hsa030300.35512336
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35485514
122cAMP signaling pathway_Homo sapiens_hsa040240.34671418
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.34426180
124GnRH signaling pathway_Homo sapiens_hsa049120.33995448
125Oocyte meiosis_Homo sapiens_hsa041140.31898594
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31579707
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31304998
128Mismatch repair_Homo sapiens_hsa034300.30877843
129Pyrimidine metabolism_Homo sapiens_hsa002400.30583851
130Galactose metabolism_Homo sapiens_hsa000520.30174709
131Oxytocin signaling pathway_Homo sapiens_hsa049210.30156325

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