PTPN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.55663250
2DNA replication checkpoint (GO:0000076)4.15768993
3purine nucleobase biosynthetic process (GO:0009113)4.12528330
4maturation of SSU-rRNA (GO:0030490)4.07500171
5nucleobase biosynthetic process (GO:0046112)3.87761810
6metaphase plate congression (GO:0051310)3.80685493
7CENP-A containing nucleosome assembly (GO:0034080)3.78517696
8ribosome assembly (GO:0042255)3.75928898
9ribosome biogenesis (GO:0042254)3.72484596
10regulation of spindle organization (GO:0090224)3.67297049
11chromatin remodeling at centromere (GO:0031055)3.63565947
12formation of translation preinitiation complex (GO:0001731)3.61529878
13attachment of spindle microtubules to kinetochore (GO:0008608)3.60689693
14DNA deamination (GO:0045006)3.59132347
15regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57970498
16ribosomal small subunit assembly (GO:0000028)3.56124846
17rRNA modification (GO:0000154)3.54318404
18protein K6-linked ubiquitination (GO:0085020)3.52670576
19positive regulation of gamma-delta T cell activation (GO:0046645)3.50990792
20protein localization to kinetochore (GO:0034501)3.49978108
21telomere maintenance via semi-conservative replication (GO:0032201)3.48909689
22telomere maintenance via recombination (GO:0000722)3.44995298
23DNA replication initiation (GO:0006270)3.42961833
24DNA replication-independent nucleosome assembly (GO:0006336)3.42717456
25DNA replication-independent nucleosome organization (GO:0034724)3.42717456
26establishment of chromosome localization (GO:0051303)3.40417776
27DNA strand elongation involved in DNA replication (GO:0006271)3.39525098
28ribonucleoprotein complex biogenesis (GO:0022613)3.37037983
29DNA strand elongation (GO:0022616)3.29722548
30maturation of 5.8S rRNA (GO:0000460)3.26252270
31tryptophan catabolic process (GO:0006569)3.24845698
32indole-containing compound catabolic process (GO:0042436)3.24845698
33indolalkylamine catabolic process (GO:0046218)3.24845698
34termination of RNA polymerase I transcription (GO:0006363)3.24111217
357-methylguanosine mRNA capping (GO:0006370)3.22518949
36ribosomal large subunit biogenesis (GO:0042273)3.21717332
37histone exchange (GO:0043486)3.21652606
38mitotic recombination (GO:0006312)3.20834320
39kynurenine metabolic process (GO:0070189)3.19437774
40kinetochore organization (GO:0051383)3.18944921
417-methylguanosine RNA capping (GO:0009452)3.18407097
42RNA capping (GO:0036260)3.18407097
43mitotic nuclear envelope disassembly (GO:0007077)3.17162970
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.16417090
45termination of RNA polymerase III transcription (GO:0006386)3.16417090
46protein localization to chromosome, centromeric region (GO:0071459)3.16219611
47monoubiquitinated protein deubiquitination (GO:0035520)3.14434933
48rRNA processing (GO:0006364)3.13707572
49proteasome assembly (GO:0043248)3.13173122
50transcription elongation from RNA polymerase I promoter (GO:0006362)3.12396435
51spindle checkpoint (GO:0031577)3.10493900
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10165081
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08714054
54rRNA methylation (GO:0031167)3.08504820
55respiratory chain complex IV assembly (GO:0008535)3.06670968
56regulation of chronic inflammatory response (GO:0002676)3.06591765
57rRNA metabolic process (GO:0016072)3.04450093
58interferon-gamma production (GO:0032609)3.04175178
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02837586
60kinetochore assembly (GO:0051382)3.02537940
61tryptophan metabolic process (GO:0006568)3.02474273
62nuclear pore organization (GO:0006999)3.01402503
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00813826
64NIK/NF-kappaB signaling (GO:0038061)2.99560918
65indolalkylamine metabolic process (GO:0006586)2.99253578
66transcription-coupled nucleotide-excision repair (GO:0006283)2.98454033
67meiotic chromosome segregation (GO:0045132)2.98235305
68regulation of double-strand break repair via homologous recombination (GO:0010569)2.95810939
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95491388
70regulation of mitotic spindle organization (GO:0060236)2.94518007
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94306637
72positive regulation of defense response to virus by host (GO:0002230)2.92922524
73cytochrome complex assembly (GO:0017004)2.92846814
74telomere maintenance via telomere lengthening (GO:0010833)2.90038634
75nuclear envelope disassembly (GO:0051081)2.89734540
76membrane disassembly (GO:0030397)2.89734540
77mitotic spindle checkpoint (GO:0071174)2.89545406
78transcription from RNA polymerase I promoter (GO:0006360)2.89132325
79regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.88410165
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.87921415
81negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87921415
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87921415
83negative regulation of sister chromatid segregation (GO:0033046)2.87921415
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87221872
85negative regulation of chromosome segregation (GO:0051985)2.85080520
86spindle assembly checkpoint (GO:0071173)2.84172356
87positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83217808
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83167725
89mitotic spindle assembly checkpoint (GO:0007094)2.82157580
90tolerance induction (GO:0002507)2.80681556
91regulation of chromosome segregation (GO:0051983)2.80282102
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79743835
93transcription elongation from RNA polymerase II promoter (GO:0006368)2.77812724
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77484676
95nuclear pore complex assembly (GO:0051292)2.77347144
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77199824
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77116648
98mitotic chromosome condensation (GO:0007076)2.77064206
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76256384
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75745944
101transcription initiation from RNA polymerase I promoter (GO:0006361)2.75644957
102spliceosomal snRNP assembly (GO:0000387)2.75280039
103G1/S transition of mitotic cell cycle (GO:0000082)2.74286305
104cell cycle G1/S phase transition (GO:0044843)2.74286305
105ribosomal small subunit biogenesis (GO:0042274)2.73300805
106DNA-dependent DNA replication (GO:0006261)2.72176112
107positive regulation of chromosome segregation (GO:0051984)2.71214105
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.69628451
109immunoglobulin mediated immune response (GO:0016064)2.69171905
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.69096695
111DNA-templated transcription, elongation (GO:0006354)2.68968967
112DNA double-strand break processing (GO:0000729)2.66871003
113IMP biosynthetic process (GO:0006188)2.65906632
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.65685419
115regulation of mitotic sister chromatid separation (GO:0010965)2.65658284
116regulation of mitotic sister chromatid segregation (GO:0033047)2.65658284
117regulation of sister chromatid segregation (GO:0033045)2.65658284
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65371303
119negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63155361
120negative regulation of ligase activity (GO:0051352)2.63155361
121positive regulation of ligase activity (GO:0051351)2.62671265
122defense response to protozoan (GO:0042832)2.62111132
123regulation of RIG-I signaling pathway (GO:0039535)2.60950140
124B cell mediated immunity (GO:0019724)2.60617569
125synapsis (GO:0007129)2.60510321
126regulation of interferon-alpha production (GO:0032647)2.60069070
127RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59309019
128tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59309019
129protein complex biogenesis (GO:0070271)2.58968281
130purine deoxyribonucleotide catabolic process (GO:0009155)2.57905021
131positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57434023
132isotype switching (GO:0045190)2.56936855
133somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56936855
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56936855
135negative regulation of interleukin-12 production (GO:0032695)2.56322595
136positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55650375
137protein neddylation (GO:0045116)2.55385413
138regulation of T-helper 1 cell differentiation (GO:0045625)2.54378627
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.54319617
140L-fucose catabolic process (GO:0042355)2.52058850
141fucose catabolic process (GO:0019317)2.52058850
142L-fucose metabolic process (GO:0042354)2.52058850
143regulation of gamma-delta T cell activation (GO:0046643)2.51631957
144mitochondrial respiratory chain complex assembly (GO:0033108)2.50314277
145positive regulation of prostaglandin secretion (GO:0032308)2.50152361
146response to protozoan (GO:0001562)2.50014075
147positive regulation of interleukin-1 beta secretion (GO:0050718)2.49319526
148negative regulation of telomere maintenance (GO:0032205)2.48231027
149mast cell activation (GO:0045576)2.47836779
150positive regulation of T-helper 1 type immune response (GO:0002827)2.47371322
151regulation of interleukin-1 beta secretion (GO:0050706)2.46933902
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.44581408
153positive regulation of interleukin-12 production (GO:0032735)2.43289422
154signal peptide processing (GO:0006465)2.41836232
155CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.40917001
156T-helper cell differentiation (GO:0042093)2.40917001
157behavioral response to nicotine (GO:0035095)2.40729587
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.39635207
159NADH dehydrogenase complex assembly (GO:0010257)2.39635207
160mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39635207
161double-strand break repair via homologous recombination (GO:0000724)2.38146624
162purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.37640846
163recombinational repair (GO:0000725)2.37521731
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.36343875
165regulation of mitotic spindle checkpoint (GO:1903504)2.36343875
166response to interferon-beta (GO:0035456)2.35749614
167positive regulation of interleukin-1 secretion (GO:0050716)2.35634233
168B cell activation involved in immune response (GO:0002312)2.35536199
169regulation of cytokine secretion involved in immune response (GO:0002739)2.35192810
170water-soluble vitamin biosynthetic process (GO:0042364)2.34880382
171positive regulation of interferon-beta production (GO:0032728)2.33561935
172negative regulation of interleukin-1 beta production (GO:0032691)2.32837825
173regulation of alpha-beta T cell proliferation (GO:0046640)2.32717686
174energy coupled proton transport, down electrochemical gradient (GO:0015985)2.32524006
175ATP synthesis coupled proton transport (GO:0015986)2.32524006
176pseudouridine synthesis (GO:0001522)2.32005417
177organelle membrane fusion (GO:0090174)2.28810668
178cellular biogenic amine catabolic process (GO:0042402)2.28765853
179amine catabolic process (GO:0009310)2.28765853
180alpha-beta T cell differentiation (GO:0046632)2.28604438
181positive regulation of histone H3-K4 methylation (GO:0051571)2.27516984
182alpha-beta T cell differentiation involved in immune response (GO:0002293)2.27335432
183alpha-beta T cell activation involved in immune response (GO:0002287)2.27335432
184T cell differentiation involved in immune response (GO:0002292)2.27335432
185positive regulation of interferon-alpha production (GO:0032727)2.26662100
186regulation of regulatory T cell differentiation (GO:0045589)2.25892773
187regulation of B cell receptor signaling pathway (GO:0050855)2.25254156
188regulation of T-helper 1 type immune response (GO:0002825)2.22877372
189cellular response to interferon-beta (GO:0035458)2.22444485
190male meiosis I (GO:0007141)2.22081607
191T cell activation involved in immune response (GO:0002286)2.21285904
192alpha-beta T cell activation (GO:0046631)2.20745927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25707756
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.79174227
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.50650161
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43948466
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41399884
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.34742750
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.12557037
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00921546
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98865110
10VDR_22108803_ChIP-Seq_LS180_Human2.90739009
11ZNF274_21170338_ChIP-Seq_K562_Hela2.84323013
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79743512
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70639134
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.69940517
15VDR_23849224_ChIP-Seq_CD4+_Human2.60234323
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56808192
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52665236
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52510375
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45314557
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.40679570
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29012886
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25975265
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15665069
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12963020
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10842955
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.10390478
27ELK1_19687146_ChIP-ChIP_HELA_Human2.02180513
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01411363
29AR_21909140_ChIP-Seq_LNCAP_Human2.00296819
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99330608
31XRN2_22483619_ChIP-Seq_HELA_Human1.98795816
32FOXP3_21729870_ChIP-Seq_TREG_Human1.98272692
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97579260
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.97094105
35DCP1A_22483619_ChIP-Seq_HELA_Human1.96327280
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92974197
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91510601
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90906479
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87085667
40EWS_26573619_Chip-Seq_HEK293_Human1.86004227
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84220826
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.82261225
43* GABP_19822575_ChIP-Seq_HepG2_Human1.80449903
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77780117
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.77598276
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76949278
47* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75978953
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75126183
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73579318
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72743147
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.72019604
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70854572
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68939061
54GATA3_26560356_Chip-Seq_TH2_Human1.68559570
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66971472
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65188006
57* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64399588
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60985181
59* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58803329
60FUS_26573619_Chip-Seq_HEK293_Human1.58482752
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.57778772
62TTF2_22483619_ChIP-Seq_HELA_Human1.57524930
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55336910
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54981680
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.51860832
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51267683
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50682276
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49171117
69IGF1R_20145208_ChIP-Seq_DFB_Human1.47815962
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43686672
71IRF1_19129219_ChIP-ChIP_H3396_Human1.42490461
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42467176
73TAF15_26573619_Chip-Seq_HEK293_Human1.42190027
74* SPI1_23547873_ChIP-Seq_NB4_Human1.41446366
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41256773
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41174930
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39619548
78KDM5A_27292631_Chip-Seq_BREAST_Human1.35641737
79ER_23166858_ChIP-Seq_MCF-7_Human1.32132873
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.31829306
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31626386
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.31626386
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.30733616
84P300_19829295_ChIP-Seq_ESCs_Human1.30216558
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27857686
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.27044462
87CIITA_25753668_ChIP-Seq_RAJI_Human1.26013046
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23919999
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22460947
90GBX2_23144817_ChIP-Seq_PC3_Human1.21639071
91TP53_22573176_ChIP-Seq_HFKS_Human1.21374768
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.21207960
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20919862
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19402530
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.19001583
96* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17717091
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17560600
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16434020
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15876343
100* GATA3_27048872_Chip-Seq_THYMUS_Human1.14959295
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12345594
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12014913
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.11406186
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09629215
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09175700
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08909611
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08388879
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07894870
109* NANOG_19829295_ChIP-Seq_ESCs_Human1.07810299
110* SOX2_19829295_ChIP-Seq_ESCs_Human1.07810299
111CBP_20019798_ChIP-Seq_JUKART_Human1.07213373
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07213373
113AR_20517297_ChIP-Seq_VCAP_Human1.04813950
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03787439
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03330268
116MYC_22102868_ChIP-Seq_BL_Human1.03081077
117BCAT_22108803_ChIP-Seq_LS180_Human1.01891612
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01714878
119RUNX_20019798_ChIP-Seq_JUKART_Human1.01599195
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00523873
121TFEB_21752829_ChIP-Seq_HELA_Human1.00357601
122* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00086789
123* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00077569
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99496337
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99206802
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98592381
127EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97559096
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96699096
129TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95700963
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95347871
131MYB_26560356_Chip-Seq_TH2_Human0.95113540
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95064309
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94740669
134SALL1_21062744_ChIP-ChIP_HESCs_Human0.93766849
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92717493
136MYC_18940864_ChIP-ChIP_HL60_Human0.92386464
137HOXB7_26014856_ChIP-Seq_BT474_Human0.91910941
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.91695122
139GATA3_26560356_Chip-Seq_TH1_Human0.91569755
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90522559
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88537498
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.88417231
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87849508
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.87394630
145* MYB_26560356_Chip-Seq_TH1_Human0.86400617
146* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86375913
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86145493
148FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83478914
149* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81485231
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78405403
151* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74962696
152* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73658142
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72022447
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71380385
155* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70976405
156* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70427528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.07860280
2MP0010094_abnormal_chromosome_stability3.74210165
3MP0008057_abnormal_DNA_replication3.67397689
4MP0003111_abnormal_nucleus_morphology3.57242271
5MP0004957_abnormal_blastocyst_morpholog3.41836687
6MP0003077_abnormal_cell_cycle3.33747711
7MP0008058_abnormal_DNA_repair3.10975074
8MP0001835_abnormal_antigen_presentation2.81199726
9MP0008007_abnormal_cellular_replicative2.63949583
10MP0002396_abnormal_hematopoietic_system2.62573159
11MP0005671_abnormal_response_to2.25810347
12MP0003195_calcinosis2.23634242
13MP0003718_maternal_effect2.15880892
14MP0003763_abnormal_thymus_physiology2.14493754
15MP0003786_premature_aging2.13572457
16MP0005075_abnormal_melanosome_morpholog2.11636858
17MP0009333_abnormal_splenocyte_physiolog2.07819489
18MP0000569_abnormal_digit_pigmentation2.05226093
19MP0008877_abnormal_DNA_methylation2.01147510
20MP0003303_peritoneal_inflammation1.96388079
21MP0010307_abnormal_tumor_latency1.94940322
22MP0003806_abnormal_nucleotide_metabolis1.92962999
23MP0003123_paternal_imprinting1.90713879
24MP0008932_abnormal_embryonic_tissue1.86127788
25MP0009785_altered_susceptibility_to1.85655724
26MP0004808_abnormal_hematopoietic_stem1.71906933
27MP0001545_abnormal_hematopoietic_system1.70936613
28MP0005397_hematopoietic_system_phenotyp1.70936613
29MP0003646_muscle_fatigue1.70521264
30MP0000685_abnormal_immune_system1.69492267
31MP0003787_abnormal_imprinting1.68541705
32MP0000350_abnormal_cell_proliferation1.67809517
33* MP0002398_abnormal_bone_marrow1.67385385
34MP0001800_abnormal_humoral_immune1.64682340
35MP0009764_decreased_sensitivity_to1.63429451
36MP0005000_abnormal_immune_tolerance1.60791707
37MP0002452_abnormal_antigen_presenting1.60539641
38MP0002148_abnormal_hypersensitivity_rea1.56339537
39MP0000372_irregular_coat_pigmentation1.56166035
40MP0002420_abnormal_adaptive_immunity1.55294974
41MP0001819_abnormal_immune_cell1.55289191
42MP0003436_decreased_susceptibility_to1.54618918
43MP0002163_abnormal_gland_morphology1.52414895
44* MP0002723_abnormal_immune_serum1.51539400
45MP0001853_heart_inflammation1.50078628
46MP0000490_abnormal_crypts_of1.48675968
47* MP0000716_abnormal_immune_system1.40524300
48MP0001730_embryonic_growth_arrest1.40013007
49MP0001790_abnormal_immune_system1.38894773
50MP0005387_immune_system_phenotype1.38894773
51MP0005025_abnormal_response_to1.38832864
52MP0002405_respiratory_system_inflammati1.38789479
53MP0002019_abnormal_tumor_incidence1.38528153
54* MP0000689_abnormal_spleen_morphology1.38436316
55* MP0002722_abnormal_immune_system1.36011703
56MP0001919_abnormal_reproductive_system1.32674842
57MP0003724_increased_susceptibility_to1.32531743
58MP0005174_abnormal_tail_pigmentation1.32236053
59MP0002837_dystrophic_cardiac_calcinosis1.31387542
60MP0002419_abnormal_innate_immunity1.30261850
61MP0002006_tumorigenesis1.29279331
62* MP0002429_abnormal_blood_cell1.28932434
63MP0008875_abnormal_xenobiotic_pharmacok1.27894206
64MP0000703_abnormal_thymus_morphology1.25373205
65MP0001986_abnormal_taste_sensitivity1.22291483
66MP0002254_reproductive_system_inflammat1.21368316
67MP0004147_increased_porphyrin_level1.21305428
68MP0009046_muscle_twitch1.21151276
69MP0008872_abnormal_physiological_respon1.20419849
70MP0002102_abnormal_ear_morphology1.20036836
71MP0005084_abnormal_gallbladder_morpholo1.19203126
72MP0002210_abnormal_sex_determination1.18806578
73MP0010352_gastrointestinal_tract_polyps1.18000907
74MP0000313_abnormal_cell_death1.17582352
75MP0000858_altered_metastatic_potential1.15415944
76MP0006292_abnormal_olfactory_placode1.13489838
77MP0006035_abnormal_mitochondrial_morpho1.13459647
78MP0006036_abnormal_mitochondrial_physio1.13247200
79MP0008260_abnormal_autophagy1.12305337
80MP0002277_abnormal_respiratory_mucosa1.12021541
81MP0005410_abnormal_fertilization1.10615142
82MP0001501_abnormal_sleep_pattern1.09826807
83MP0006072_abnormal_retinal_apoptosis1.09708712
84MP0006082_CNS_inflammation1.09297249
85MP0001119_abnormal_female_reproductive1.08945785
86MP0001672_abnormal_embryogenesis/_devel1.08263800
87MP0005380_embryogenesis_phenotype1.08263800
88MP0002132_abnormal_respiratory_system1.06254301
89MP0003448_altered_tumor_morphology1.05846557
90MP0001697_abnormal_embryo_size1.05038768
91MP0002166_altered_tumor_susceptibility1.03050439
92MP0010155_abnormal_intestine_physiology1.02984709
93MP0004742_abnormal_vestibular_system1.02189027
94MP0001929_abnormal_gametogenesis0.99339832
95MP0001873_stomach_inflammation0.99256530
96MP0002693_abnormal_pancreas_physiology0.97745459
97MP0003984_embryonic_growth_retardation0.94277805
98MP0005379_endocrine/exocrine_gland_phen0.93375606
99MP0002080_prenatal_lethality0.93338457
100MP0000465_gastrointestinal_hemorrhage0.93030609
101MP0010386_abnormal_urinary_bladder0.92077368
102MP0002088_abnormal_embryonic_growth/wei0.90889868
103MP0005310_abnormal_salivary_gland0.90249958
104MP0003186_abnormal_redox_activity0.90244823
105MP0001145_abnormal_male_reproductive0.89793511
106* MP0001845_abnormal_inflammatory_respons0.88857115
107MP0000653_abnormal_sex_gland0.87620504
108MP0002095_abnormal_skin_pigmentation0.86646137
109MP0005464_abnormal_platelet_physiology0.86038229
110MP0001542_abnormal_bone_strength0.85415642
111MP0002933_joint_inflammation0.84678090
112MP0001968_abnormal_touch/_nociception0.84295265
113MP0000427_abnormal_hair_cycle0.83409407
114MP0002009_preneoplasia0.82823837
115MP0002736_abnormal_nociception_after0.81984143
116MP0005266_abnormal_metabolism0.81931592
117MP0005551_abnormal_eye_electrophysiolog0.81857633
118MP0009697_abnormal_copulation0.81696560
119MP0002086_abnormal_extraembryonic_tissu0.81089659
120MP0001533_abnormal_skeleton_physiology0.80767057
121MP0004142_abnormal_muscle_tone0.80348216
122MP0001663_abnormal_digestive_system0.77060451
123MP0000015_abnormal_ear_pigmentation0.76844872
124MP0002138_abnormal_hepatobiliary_system0.75047286
125MP0001485_abnormal_pinna_reflex0.73060529
126MP0002085_abnormal_embryonic_tissue0.72896043
127MP0009765_abnormal_xenobiotic_induced0.72245810
128MP0003828_pulmonary_edema0.71799336
129MP0000627_abnormal_mammary_gland0.70203589
130MP0009763_increased_sensitivity_to0.69696809
131MP0003943_abnormal_hepatobiliary_system0.69179803
132MP0005395_other_phenotype0.68642898
133MP0005076_abnormal_cell_differentiation0.68630319
134MP0005621_abnormal_cell_physiology0.68566937
135MP0008995_early_reproductive_senescence0.68254971
136MP0005023_abnormal_wound_healing0.64519659
137MP0008469_abnormal_protein_level0.64346578
138MP0009278_abnormal_bone_marrow0.63689640
139MP0001764_abnormal_homeostasis0.63457379
140MP0003121_genomic_imprinting0.63177213
141MP0005389_reproductive_system_phenotype0.62718509

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.99605762
2Irregular epiphyses (HP:0010582)4.00759469
3Stomatitis (HP:0010280)3.95657334
4Chromsome breakage (HP:0040012)3.87619331
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74159946
6Abnormality of B cell number (HP:0010975)3.73381647
7Breast hypoplasia (HP:0003187)3.48111929
8B lymphocytopenia (HP:0010976)3.33806401
9Carpal bone hypoplasia (HP:0001498)3.25870240
10Reticulocytopenia (HP:0001896)3.15378107
11Abnormality of the preputium (HP:0100587)3.10847991
12Rough bone trabeculation (HP:0100670)3.07439579
13Flat capital femoral epiphysis (HP:0003370)3.05817612
14Abnormality of chromosome stability (HP:0003220)2.99885554
15Patellar aplasia (HP:0006443)2.93962418
16Meckel diverticulum (HP:0002245)2.90901513
17Abnormal spermatogenesis (HP:0008669)2.85239777
18Myelodysplasia (HP:0002863)2.82119254
19Aplastic anemia (HP:0001915)2.80373279
20Severe combined immunodeficiency (HP:0004430)2.79577484
21Small epiphyses (HP:0010585)2.76823092
22Aplasia/Hypoplasia of the patella (HP:0006498)2.76523695
23IgM deficiency (HP:0002850)2.75008784
24Impulsivity (HP:0100710)2.73025798
25Abnormality of the ileum (HP:0001549)2.72725546
26Abnormality of the anterior horn cell (HP:0006802)2.71725841
27Degeneration of anterior horn cells (HP:0002398)2.71725841
28Mitochondrial inheritance (HP:0001427)2.69254800
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.68163765
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65981322
31Abnormality of alanine metabolism (HP:0010916)2.65981322
32Hyperalaninemia (HP:0003348)2.65981322
33Increased CSF lactate (HP:0002490)2.63155004
34Abnormality of cells of the erythroid lineage (HP:0012130)2.62129142
35Abnormality of midbrain morphology (HP:0002418)2.60512830
36Molar tooth sign on MRI (HP:0002419)2.60512830
37Abnormal number of erythroid precursors (HP:0012131)2.59913786
38Acute necrotizing encephalopathy (HP:0006965)2.57424747
39Entropion (HP:0000621)2.56108467
40Thyroiditis (HP:0100646)2.53047205
41Congenital stationary night blindness (HP:0007642)2.52034608
42Hepatocellular necrosis (HP:0001404)2.50492198
4311 pairs of ribs (HP:0000878)2.49980283
44IgG deficiency (HP:0004315)2.46854085
45Combined immunodeficiency (HP:0005387)2.45833362
46Absent epiphyses (HP:0010577)2.45434585
47Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.45434585
48Abnormality of T cell number (HP:0011839)2.45396405
49Bone marrow hypocellularity (HP:0005528)2.44969798
50Recurrent abscess formation (HP:0002722)2.44558758
51Abnormal trabecular bone morphology (HP:0100671)2.43417333
52Thrombocytosis (HP:0001894)2.42663766
53Oral leukoplakia (HP:0002745)2.39266633
54Stomach cancer (HP:0012126)2.33876017
55Abnormal mitochondria in muscle tissue (HP:0008316)2.33166176
56Abolished electroretinogram (ERG) (HP:0000550)2.32870378
57T lymphocytopenia (HP:0005403)2.32322784
58Microretrognathia (HP:0000308)2.32026064
593-Methylglutaconic aciduria (HP:0003535)2.31424307
60True hermaphroditism (HP:0010459)2.29281839
61Abnormality of the renal cortex (HP:0011035)2.29060655
62Capillary hemangiomas (HP:0005306)2.25555517
63Hepatic necrosis (HP:0002605)2.25510506
64Small intestinal stenosis (HP:0012848)2.24603280
65Duodenal stenosis (HP:0100867)2.24603280
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23451050
67Bile duct proliferation (HP:0001408)2.22176220
68Abnormal biliary tract physiology (HP:0012439)2.22176220
69Abnormal rod and cone electroretinograms (HP:0008323)2.21879339
70Recurrent fungal infections (HP:0002841)2.21529252
71Acute encephalopathy (HP:0006846)2.21188918
72Progressive macrocephaly (HP:0004481)2.20715763
73Clubbing of toes (HP:0100760)2.20461105
74Increased hepatocellular lipid droplets (HP:0006565)2.18708946
75Cleft eyelid (HP:0000625)2.17763425
76Autoimmune hemolytic anemia (HP:0001890)2.17028641
77Eczematoid dermatitis (HP:0000976)2.16555414
78Lymphoma (HP:0002665)2.15987516
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.14592037
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14542362
81Genu varum (HP:0002970)2.14297957
82Pancreatic fibrosis (HP:0100732)2.13122397
83Absent thumb (HP:0009777)2.13105079
84Azoospermia (HP:0000027)2.12304564
85Autoimmune thrombocytopenia (HP:0001973)2.11730843
86Increased IgM level (HP:0003496)2.10411868
87Abnormality of the femoral head (HP:0003368)2.09897849
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08720328
89Myositis (HP:0100614)2.08024243
90Glossoptosis (HP:0000162)2.08020739
91Abnormality of the epiphysis of the femoral head (HP:0010574)2.07378949
92Recurrent bacterial skin infections (HP:0005406)2.05821442
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.05107918
94Abnormality of femoral epiphyses (HP:0006499)2.05107918
95Pustule (HP:0200039)2.04682734
96Premature graying of hair (HP:0002216)2.03841219
97Nephronophthisis (HP:0000090)2.03566324
98Lipid accumulation in hepatocytes (HP:0006561)2.03141631
99Methylmalonic aciduria (HP:0012120)2.00974614
100Increased serum lactate (HP:0002151)2.00328059
101Attenuation of retinal blood vessels (HP:0007843)2.00111771
102Sloping forehead (HP:0000340)1.99898944
103Abnormality of the prostate (HP:0008775)1.97802103
104Acute myeloid leukemia (HP:0004808)1.96977467
105Type 2 muscle fiber atrophy (HP:0003554)1.96234297
106Abnormality of eosinophils (HP:0001879)1.96032770
107Selective tooth agenesis (HP:0001592)1.95596853
108Abnormality of the pons (HP:0007361)1.94992627
109IgA deficiency (HP:0002720)1.94860480
110Stillbirth (HP:0003826)1.94409484
111Recurrent bronchitis (HP:0002837)1.94304868
112Absent/shortened dynein arms (HP:0200106)1.93487588
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.93487588
114Methylmalonic acidemia (HP:0002912)1.93143912
115Pulmonary fibrosis (HP:0002206)1.93094768
116Type I transferrin isoform profile (HP:0003642)1.92995965
117Muscle fiber atrophy (HP:0100295)1.92727945
118Recurrent cutaneous fungal infections (HP:0011370)1.92314273
119Chronic mucocutaneous candidiasis (HP:0002728)1.92314273
120Aseptic necrosis (HP:0010885)1.92135689
121Prostate neoplasm (HP:0100787)1.91329374
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91279792
123Abnormality of T cells (HP:0002843)1.91251255
124Pancreatic cysts (HP:0001737)1.90138857
125Encephalitis (HP:0002383)1.90128953
126Mediastinal lymphadenopathy (HP:0100721)1.89900877
127Colon cancer (HP:0003003)1.88571832
128Delayed epiphyseal ossification (HP:0002663)1.88515828
129Abnormality of T cell physiology (HP:0011840)1.86604730
130Pallor (HP:0000980)1.86032532
131Abnormality of the renal medulla (HP:0100957)1.85930272
132Panhypogammaglobulinemia (HP:0003139)1.85875169
133Gaze-evoked nystagmus (HP:0000640)1.85825813
134Ureteral duplication (HP:0000073)1.85329108
135Abnormality of DNA repair (HP:0003254)1.85221629
136Ectopic kidney (HP:0000086)1.84492963
137Absent radius (HP:0003974)1.82795036
138Abnormality of the fingertips (HP:0001211)1.82717026
139Orchitis (HP:0100796)1.82620568
140Hypoplasia of the pons (HP:0012110)1.82501656
141Optic neuritis (HP:0100653)1.82221125
142Retrobulbar optic neuritis (HP:0100654)1.82221125
143Secondary amenorrhea (HP:0000869)1.82047306
144Poor head control (HP:0002421)1.81385609
145Multiple enchondromatosis (HP:0005701)1.80572873
146Elevated erythrocyte sedimentation rate (HP:0003565)1.80519964
147Exertional dyspnea (HP:0002875)1.79906334
148Neutropenia (HP:0001875)1.79564216
149Constricted visual fields (HP:0001133)1.79515099
150Progressive inability to walk (HP:0002505)1.79074395
151Short middle phalanx of the 5th finger (HP:0004220)1.78859800
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78665777
153Epiphyseal dysplasia (HP:0002656)1.78485683
154Prominent nose (HP:0000448)1.77950326
155Lactic acidosis (HP:0003128)1.77503567
156Vasculitis (HP:0002633)1.77328577
157Leukopenia (HP:0001882)1.77208827
158Keratoconjunctivitis (HP:0001096)1.76491570
159Abnormality of the duodenum (HP:0002246)1.76460123
160Facial hemangioma (HP:0000329)1.76418983
161Cellular immunodeficiency (HP:0005374)1.76308891
162Renal cortical cysts (HP:0000803)1.76071134
163Macrocytic anemia (HP:0001972)1.76045545
164Agnosia (HP:0010524)1.75604068
165Polydipsia (HP:0001959)1.74676502
166Abnormal drinking behavior (HP:0030082)1.74676502
167Triphalangeal thumb (HP:0001199)1.73943752
168Medial flaring of the eyebrow (HP:0010747)1.73762399
169Tracheoesophageal fistula (HP:0002575)1.73733291
170Recurrent pneumonia (HP:0006532)1.73520417
171Hemoptysis (HP:0002105)1.73430013
172Eosinophilia (HP:0001880)1.73388151
173Aplasia/hypoplasia of the uterus (HP:0008684)1.72198409
174Optic disc pallor (HP:0000543)1.70362132
175Tubular atrophy (HP:0000092)1.69687499
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.67625540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.85211939
2WEE13.81867254
3EIF2AK13.28581119
4FRK3.27780738
5TAOK32.76210434
6BRSK22.74382012
7ADRBK22.74084628
8NME22.48270320
9ACVR1B2.40591316
10CDC72.36721574
11PLK42.36189775
12NEK22.30889220
13SRPK12.29073240
14BMPR1B2.27502363
15EIF2AK32.25438990
16MKNK22.23791738
17RPS6KA42.08483396
18MAP3K121.99885488
19MKNK11.91318978
20STK161.84065370
21PLK11.82004160
22GRK11.76064377
23DYRK31.71190997
24MAP3K141.69397086
25TXK1.68421283
26TTK1.65130790
27PLK31.63275884
28TSSK61.62201892
29MAP4K11.58967230
30PIM21.56482338
31WNK31.55261513
32VRK11.55227963
33MAP4K21.54001814
34CCNB11.49932305
35STK38L1.46478994
36AURKB1.44883568
37TRIM281.37076781
38GRK71.36733669
39BRSK11.35772381
40NUAK11.34581534
41PIM11.34432775
42MST41.31325316
43CDK191.30979751
44IRAK31.30408577
45ZAK1.26854384
46PBK1.26202776
47EIF2AK21.25836094
48ATR1.24559532
49CDK81.24460770
50OXSR11.23418329
51JAK31.20660468
52CHEK21.20569283
53IKBKB1.20148154
54STK101.16987623
55NEK11.15837490
56ITK1.15492002
57WNK41.12800187
58STK241.11281438
59TEC1.10105115
60MATK1.09773055
61STK31.09483361
62MAP3K31.07820454
63IRAK41.07475276
64ZAP701.07290490
65CDK41.06860196
66MARK31.06377440
67TYK21.05854405
68CAMKK21.05646731
69CDK71.01038365
70INSRR0.99674372
71IRAK10.98918679
72CSNK1G10.98269286
73NLK0.97942468
74VRK20.94076186
75KIT0.93756830
76STK40.90330138
77CSK0.90044359
78IKBKE0.89956961
79PRKCQ0.88727464
80CSNK1G30.88485040
81CHUK0.87845912
82MAP3K80.83728690
83PINK10.83675361
84MAP2K30.80733163
85CHEK10.79610343
86TESK20.78756959
87PASK0.76844577
88TLK10.76787924
89AKT30.74258668
90MAPK130.72236658
91MAP3K130.71855238
92BRAF0.71701283
93CSNK1G20.71697594
94STK390.70186414
95TGFBR10.69436789
96CSNK1A1L0.67044835
97MAP3K40.65516759
98AURKA0.64822887
99ATM0.61121924
100FES0.60924937
101TBK10.60557282
102RIPK40.60322062
103RPS6KB20.59802678
104RPS6KA50.59782498
105CDK30.59423065
106EPHA20.57799024
107FGR0.57043376
108PDK20.56674042
109ERBB30.56519427
110BLK0.56242125
111NEK90.56096965
112CSNK2A10.54546793
113MELK0.53423352
114BTK0.53333262
115ADRBK10.53200260
116BCR0.52851977
117MAP3K90.52811640
118NME10.52489912
119SIK30.50809596
120BMPR20.50002894
121* CDK20.48158780
122RAF10.47361732
123TNIK0.46365287
124TAF10.45859262
125MAP3K60.45782323
126FLT30.44515431
127CSNK2A20.44307387
128MAP3K50.44022419
129TNK20.42030946
130SYK0.41902976
131JAK10.41463414
132LYN0.41221162
133KDR0.40406812
134ABL20.40269443
135CSF1R0.39791013
136PRKCI0.39405920
137DYRK20.39318805
138EGFR0.37767675
139* CDK10.35556613
140PDK40.34335162
141PDK30.34335162
142LCK0.33976996
143CDK60.32659922

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77487530
2RNA polymerase_Homo sapiens_hsa030203.59556074
3DNA replication_Homo sapiens_hsa030303.55717195
4Proteasome_Homo sapiens_hsa030503.06619844
5Mismatch repair_Homo sapiens_hsa034302.89757142
6RNA transport_Homo sapiens_hsa030132.71633391
7Homologous recombination_Homo sapiens_hsa034402.68093503
8Ribosome_Homo sapiens_hsa030102.56881464
9Spliceosome_Homo sapiens_hsa030402.55247197
10Basal transcription factors_Homo sapiens_hsa030222.46533375
11Base excision repair_Homo sapiens_hsa034102.43253189
12Cell cycle_Homo sapiens_hsa041102.42263501
13Nucleotide excision repair_Homo sapiens_hsa034202.40505525
14Pyrimidine metabolism_Homo sapiens_hsa002402.30019661
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28111485
16Oxidative phosphorylation_Homo sapiens_hsa001902.25249126
17Fanconi anemia pathway_Homo sapiens_hsa034602.19549365
18Vitamin B6 metabolism_Homo sapiens_hsa007502.00220860
19RNA degradation_Homo sapiens_hsa030181.90225915
20Parkinsons disease_Homo sapiens_hsa050121.78839951
21p53 signaling pathway_Homo sapiens_hsa041151.77796267
22Non-homologous end-joining_Homo sapiens_hsa034501.66856493
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64872717
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.56081833
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.55459661
26Herpes simplex infection_Homo sapiens_hsa051681.54866737
27Protein export_Homo sapiens_hsa030601.41993278
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41219736
29Epstein-Barr virus infection_Homo sapiens_hsa051691.39800808
30Purine metabolism_Homo sapiens_hsa002301.38887630
31Nitrogen metabolism_Homo sapiens_hsa009101.34004258
32Antigen processing and presentation_Homo sapiens_hsa046121.33737265
33Staphylococcus aureus infection_Homo sapiens_hsa051501.32698322
34Primary immunodeficiency_Homo sapiens_hsa053401.31963511
35Allograft rejection_Homo sapiens_hsa053301.31920638
36Graft-versus-host disease_Homo sapiens_hsa053321.30844872
37One carbon pool by folate_Homo sapiens_hsa006701.30090289
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28455639
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25288470
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25077691
41Asthma_Homo sapiens_hsa053101.24587985
42mRNA surveillance pathway_Homo sapiens_hsa030151.21838503
43Measles_Homo sapiens_hsa051621.19333983
44Legionellosis_Homo sapiens_hsa051341.18383495
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15174222
46Huntingtons disease_Homo sapiens_hsa050161.15051896
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11901331
48Phototransduction_Homo sapiens_hsa047441.11708081
49Linoleic acid metabolism_Homo sapiens_hsa005911.06718018
50Leishmaniasis_Homo sapiens_hsa051401.02988751
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02206093
52Hematopoietic cell lineage_Homo sapiens_hsa046401.02121554
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99139859
54Tryptophan metabolism_Homo sapiens_hsa003800.98361238
55Alzheimers disease_Homo sapiens_hsa050100.96817004
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91417064
57Influenza A_Homo sapiens_hsa051640.89534652
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87197556
59Folate biosynthesis_Homo sapiens_hsa007900.86207999
60Regulation of autophagy_Homo sapiens_hsa041400.83801383
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81904605
62Viral carcinogenesis_Homo sapiens_hsa052030.80838373
63Pentose phosphate pathway_Homo sapiens_hsa000300.80115327
64Autoimmune thyroid disease_Homo sapiens_hsa053200.79915344
65Apoptosis_Homo sapiens_hsa042100.79568202
66Ether lipid metabolism_Homo sapiens_hsa005650.78810277
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78076129
68HTLV-I infection_Homo sapiens_hsa051660.77775557
69Type I diabetes mellitus_Homo sapiens_hsa049400.74942769
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72222710
71TNF signaling pathway_Homo sapiens_hsa046680.70896863
72* Jak-STAT signaling pathway_Homo sapiens_hsa046300.69537730
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68388599
74Collecting duct acid secretion_Homo sapiens_hsa049660.66612714
75Hepatitis B_Homo sapiens_hsa051610.66421259
76Malaria_Homo sapiens_hsa051440.66124662
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66118306
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64305897
79Sulfur metabolism_Homo sapiens_hsa009200.61422548
80Oocyte meiosis_Homo sapiens_hsa041140.60256273
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60068755
82Rheumatoid arthritis_Homo sapiens_hsa053230.58875909
83Systemic lupus erythematosus_Homo sapiens_hsa053220.56664400
84Caffeine metabolism_Homo sapiens_hsa002320.55975460
85Shigellosis_Homo sapiens_hsa051310.55067315
86Osteoclast differentiation_Homo sapiens_hsa043800.54367777
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53529270
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52901052
89Small cell lung cancer_Homo sapiens_hsa052220.52423416
90Peroxisome_Homo sapiens_hsa041460.51627791
91T cell receptor signaling pathway_Homo sapiens_hsa046600.49718366
92Butanoate metabolism_Homo sapiens_hsa006500.48834283
93Tuberculosis_Homo sapiens_hsa051520.48658864
94Toxoplasmosis_Homo sapiens_hsa051450.48113153
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47019458
96Propanoate metabolism_Homo sapiens_hsa006400.43704612
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.40532667
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40398027
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.39607843
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.38850040
101Taste transduction_Homo sapiens_hsa047420.38498251
102Chemokine signaling pathway_Homo sapiens_hsa040620.36154644
103Other glycan degradation_Homo sapiens_hsa005110.35646658
104Steroid biosynthesis_Homo sapiens_hsa001000.35603522
105MicroRNAs in cancer_Homo sapiens_hsa052060.35202691
106Sulfur relay system_Homo sapiens_hsa041220.35056241
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35007973
108Olfactory transduction_Homo sapiens_hsa047400.34510614
109Pertussis_Homo sapiens_hsa051330.33510763
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33345729
111Arachidonic acid metabolism_Homo sapiens_hsa005900.32585533
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.31727493
113Thyroid cancer_Homo sapiens_hsa052160.31443262
114Viral myocarditis_Homo sapiens_hsa054160.31123250
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30268901
116B cell receptor signaling pathway_Homo sapiens_hsa046620.28987951
117FoxO signaling pathway_Homo sapiens_hsa040680.28774742
118Metabolic pathways_Homo sapiens_hsa011000.27925887
119Renin-angiotensin system_Homo sapiens_hsa046140.26016037
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25572389
121TGF-beta signaling pathway_Homo sapiens_hsa043500.25426945
122Vitamin digestion and absorption_Homo sapiens_hsa049770.25326257
123Glutathione metabolism_Homo sapiens_hsa004800.24546512
124Salmonella infection_Homo sapiens_hsa051320.23188469
125Hepatitis C_Homo sapiens_hsa051600.22944513
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21967953
127Circadian rhythm_Homo sapiens_hsa047100.21621177
128HIF-1 signaling pathway_Homo sapiens_hsa040660.19651493
129Selenocompound metabolism_Homo sapiens_hsa004500.18765558
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18075642
131Prolactin signaling pathway_Homo sapiens_hsa049170.17559875
132Phagosome_Homo sapiens_hsa041450.17298376
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17210494
134African trypanosomiasis_Homo sapiens_hsa051430.16793221
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15930034

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