ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	8.26141129
2	spermatid nucleus differentiation (GO:0007289)	7.49766535
3	rRNA methylation (GO:0031167)	7.31603921
4	centriole replication (GO:0007099)	7.25299425
5	acrosome reaction (GO:0007340)	6.95502149
6	protein polyglutamylation (GO:0018095)	6.53355597
7	microtubule depolymerization (GO:0007019)	6.46599919
8	response to pheromone (GO:0019236)	6.43444750
9	rRNA modification (GO:0000154)	6.41763590
10	regulation of centriole replication (GO:0046599)	6.30044393
11	fusion of sperm to egg plasma membrane (GO:0007342)	6.07647595
12	centriole assembly (GO:0098534)	6.06999267
13	sperm capacitation (GO:0048240)	5.97139648
14	chromosome condensation (GO:0030261)	5.60346469
15	microtubule polymerization or depolymerization (GO:0031109)	5.51486359
16	protein targeting to Golgi (GO:0000042)	5.46284821
17	seminiferous tubule development (GO:0072520)	5.42461769
18	axonemal dynein complex assembly (GO:0070286)	5.37309999
19	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.35628621
20	epithelial cilium movement (GO:0003351)	5.31576475
21	DNA packaging (GO:0006323)	5.26300512
22	establishment of protein localization to Golgi (GO:0072600)	5.25989893
23	multicellular organism reproduction (GO:0032504)	5.11275480
24	spermatid development (GO:0007286)	5.00021048
25	sperm-egg recognition (GO:0035036)	4.77314523
26	plasma membrane fusion (GO:0045026)	4.63713424
27	protein localization to Golgi apparatus (GO:0034067)	4.54682473
28	cilium or flagellum-dependent cell motility (GO:0001539)	4.54535507
29	cellular ketone body metabolic process (GO:0046950)	4.54030999
30	Golgi to endosome transport (GO:0006895)	4.53939549
31	cilium movement (GO:0003341)	4.49827932
32	male gamete generation (GO:0048232)	4.38112050
33	spermatogenesis (GO:0007283)	4.36343039
34	reproduction (GO:0000003)	4.31253060
35	single strand break repair (GO:0000012)	4.22122062
36	motile cilium assembly (GO:0044458)	4.19438684
37	calcium ion-dependent exocytosis (GO:0017156)	4.08394527
38	gamete generation (GO:0007276)	4.05048257
39	left/right axis specification (GO:0070986)	4.04660595
40	pattern specification involved in kidney development (GO:0061004)	4.02828948
41	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.00443452
42	ketone body metabolic process (GO:1902224)	3.97315560
43	binding of sperm to zona pellucida (GO:0007339)	3.95773892
44	male meiosis I (GO:0007141)	3.93350714
45	axoneme assembly (GO:0035082)	3.92826844
46	positive regulation of respiratory burst (GO:0060267)	3.89808596
47	phosphatidylethanolamine metabolic process (GO:0046337)	3.87730981
48	positive regulation of vascular permeability (GO:0043117)	3.81044099
49	autophagic vacuole fusion (GO:0000046)	3.80579893
50	preassembly of GPI anchor in ER membrane (GO:0016254)	3.75628679
51	auditory receptor cell differentiation (GO:0042491)	3.69675377
52	RNA destabilization (GO:0050779)	3.69340016
53	cell-cell recognition (GO:0009988)	3.68857821
54	positive regulation of Rab GTPase activity (GO:0032851)	3.63955989
55	regulation of Rab GTPase activity (GO:0032313)	3.63955989
56	single fertilization (GO:0007338)	3.60924990
57	organelle membrane fusion (GO:0090174)	3.59850216
58	fertilization (GO:0009566)	3.57100520
59	regulation of cilium movement (GO:0003352)	3.56032481
60	microtubule nucleation (GO:0007020)	3.50073548
61	GPI anchor biosynthetic process (GO:0006506)	3.45114776
62	C-terminal protein lipidation (GO:0006501)	3.41272115
63	estrogen biosynthetic process (GO:0006703)	3.39748901
64	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.37198756
65	cell wall macromolecule catabolic process (GO:0016998)	3.34728609
66	early endosome to late endosome transport (GO:0045022)	3.28009570
67	retinal rod cell development (GO:0046548)	3.26437832
68	chemosensory behavior (GO:0007635)	3.23504901
69	GPI anchor metabolic process (GO:0006505)	3.21949819
70	multicellular organismal reproductive process (GO:0048609)	3.20703864
71	negative regulation of glucose import (GO:0046325)	3.18671845
72	regulation of centrosome duplication (GO:0010824)	3.16937871
73	cell wall macromolecule metabolic process (GO:0044036)	3.13138868
74	nephron tubule morphogenesis (GO:0072078)	3.05476467
75	nephron epithelium morphogenesis (GO:0072088)	3.05476467
76	cilium organization (GO:0044782)	2.99107249
77	microtubule severing (GO:0051013)	2.96126451
78	resolution of meiotic recombination intermediates (GO:0000712)	2.95587404
79	C-terminal protein amino acid modification (GO:0018410)	2.90624187
80	meiosis I (GO:0007127)	2.90618559
81	spinal cord motor neuron differentiation (GO:0021522)	2.87070422
82	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86783014
83	neuron fate determination (GO:0048664)	2.85560634
84	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.84670572
85	germ cell development (GO:0007281)	2.84615077
86	sexual reproduction (GO:0019953)	2.80631581
87	vesicle transport along microtubule (GO:0047496)	2.79922042
88	RNA methylation (GO:0001510)	2.78403591
89	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.77867925
90	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.75795350
91	protein complex biogenesis (GO:0070271)	2.73274142
92	nucleus organization (GO:0006997)	2.72762233
93	cilium assembly (GO:0042384)	2.70818949
94	alanine transport (GO:0032328)	2.70489825
95	RNA localization (GO:0006403)	2.70109273
96	regulation of centrosome cycle (GO:0046605)	2.67546374
97	inner ear receptor cell differentiation (GO:0060113)	2.67328988
98	mannosylation (GO:0097502)	2.65953929
99	microtubule bundle formation (GO:0001578)	2.65678851
100	intra-Golgi vesicle-mediated transport (GO:0006891)	2.60518969

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.22293553
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.16546393
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.05546394
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.05066212
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.56320272
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44729717
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.20616853
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20616853
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16951554
10	CBP_20019798_ChIP-Seq_JUKART_Human	2.11120353
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.11120353
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09025666
13	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.06423984
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02798733
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.99280001
16	FUS_26573619_Chip-Seq_HEK293_Human	1.91469656
17	VDR_22108803_ChIP-Seq_LS180_Human	1.87736710
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.84821699
19	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.82045178
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.82038000
21	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.79949375
22	AR_25329375_ChIP-Seq_VCAP_Human	1.79344227
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.76250241
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.70968932
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.67690867
26	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.61170578
27	ERA_21632823_ChIP-Seq_H3396_Human	1.60258704
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58033901
29	P300_19829295_ChIP-Seq_ESCs_Human	1.56755896
30	NANOG_20526341_ChIP-Seq_ESCs_Human	1.54823980
31	TAF2_19829295_ChIP-Seq_ESCs_Human	1.50526464
32	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48822815
33	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.48321553
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46968856
35	MYC_19829295_ChIP-Seq_ESCs_Human	1.46393108
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44878810
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43290056
38	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.41311273
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.39945228
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.39561839
41	RBPJ_21746931_ChIP-Seq_IB4_Human	1.38045457
42	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.37753049
43	PHF8_20622853_ChIP-Seq_HELA_Human	1.34499300
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33737887
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32575242
46	STAT3_23295773_ChIP-Seq_U87_Human	1.32104029
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30293356
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30293356
49	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.27798116
50	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.24951594
51	ETV1_20927104_ChIP-Seq_GIST48_Human	1.23104574
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22541048
53	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.21565053
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.20577700
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19169611
56	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.18133943
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.18073843
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17387571
59	NFYB_21822215_ChIP-Seq_K562_Human	1.16632868
60	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15940927
61	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15786781
62	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.15092747
63	TBL1_22424771_ChIP-Seq_293T_Human	1.13754893
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13596716
65	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10990792
66	RAC3_21632823_ChIP-Seq_H3396_Human	1.10540742
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10166208
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09646982
69	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09063590
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08359347
71	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.08308627
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07668381
73	OCT4_20526341_ChIP-Seq_ESCs_Human	1.07648622
74	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.07289112
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06967187
76	SMC4_20622854_ChIP-Seq_HELA_Human	1.06481330
77	NFYA_21822215_ChIP-Seq_K562_Human	1.05121032
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04921888
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04921888
80	TCF4_23295773_ChIP-Seq_U87_Human	1.04793362
81	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04676477
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04042396
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03014491
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.02912566
85	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02901983
86	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.02655828
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02469383
88	TAF15_26573619_Chip-Seq_HEK293_Human	1.02161762
89	NCOR_22424771_ChIP-Seq_293T_Human	1.01452458
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01385796
91	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.01154588
92	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00342012
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00041020
94	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99773149
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99526236
96	BCL6_27268052_Chip-Seq_Bcells_Human	0.98991276
97	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.98970150
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.98859038
99	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96945858
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96850670

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.61339135
2	MP0003878_abnormal_ear_physiology	3.76807338
3	MP0005377_hearing/vestibular/ear_phenot	3.76807338
4	MP0003011_delayed_dark_adaptation	3.60858794
5	MP0002234_abnormal_pharynx_morphology	3.15943939
6	MP0003195_calcinosis	3.01065482
7	MP0003698_abnormal_male_reproductive	2.71507232
8	MP0001929_abnormal_gametogenesis	2.58062905
9	MP0003718_maternal_effect	2.43231255
10	MP0005645_abnormal_hypothalamus_physiol	2.42747094
11	MP0002653_abnormal_ependyma_morphology	2.40609259
12	MP0003646_muscle_fatigue	2.39742002
13	MP0005670_abnormal_white_adipose	2.28862684
14	MP0005551_abnormal_eye_electrophysiolog	2.10186868
15	MP0005084_abnormal_gallbladder_morpholo	2.06262717
16	MP0002282_abnormal_trachea_morphology	1.85108345
17	MP0005379_endocrine/exocrine_gland_phen	1.78343710
18	MP0001485_abnormal_pinna_reflex	1.77244484
19	MP0008995_early_reproductive_senescence	1.76254722
20	MP0008877_abnormal_DNA_methylation	1.71272897
21	MP0005310_abnormal_salivary_gland	1.69562156
22	MP0004742_abnormal_vestibular_system	1.62442650
23	MP0001486_abnormal_startle_reflex	1.61403183
24	MP0003283_abnormal_digestive_organ	1.59216690
25	MP0004859_abnormal_synaptic_plasticity	1.55486927
26	MP0005083_abnormal_biliary_tract	1.55358622
27	MP0002210_abnormal_sex_determination	1.50218507
28	MP0002161_abnormal_fertility/fecundity	1.49146759
29	MP0000678_abnormal_parathyroid_gland	1.47563715
30	MP0003137_abnormal_impulse_conducting	1.45886178
31	MP0002735_abnormal_chemical_nociception	1.44095004
32	MP0005253_abnormal_eye_physiology	1.40091164
33	MP0001324_abnormal_eye_pigmentation	1.36408964
34	MP0002229_neurodegeneration	1.32236420
35	MP0000653_abnormal_sex_gland	1.22832917
36	MP0002909_abnormal_adrenal_gland	1.20919131
37	MP0008057_abnormal_DNA_replication	1.20901510
38	MP0002822_catalepsy	1.20639071
39	MP0005395_other_phenotype	1.19558641
40	MP0005174_abnormal_tail_pigmentation	1.17900654
41	MP0002557_abnormal_social/conspecific_i	1.17691578
42	MP0001963_abnormal_hearing_physiology	1.17282757
43	MP0001984_abnormal_olfaction	1.15914268
44	MP0006072_abnormal_retinal_apoptosis	1.15059798
45	MP0005220_abnormal_exocrine_pancreas	1.14308723
46	MP0001145_abnormal_male_reproductive	1.13577825
47	MP0000955_abnormal_spinal_cord	1.09645467
48	MP0002638_abnormal_pupillary_reflex	1.07160068
49	MP0003787_abnormal_imprinting	1.06478216
50	MP0005636_abnormal_mineral_homeostasis	1.05313660
51	MP0005646_abnormal_pituitary_gland	1.04217795
52	MP0000026_abnormal_inner_ear	1.04188018
53	MP0000613_abnormal_salivary_gland	1.03220733
54	MP0009046_muscle_twitch	1.02285642
55	MP0002067_abnormal_sensory_capabilities	1.02017613
56	MP0002928_abnormal_bile_duct	1.01074413
57	MP0002163_abnormal_gland_morphology	1.01001727
58	MP0009780_abnormal_chondrocyte_physiolo	1.00021442
59	MP0004133_heterotaxia	0.98773913
60	MP0008961_abnormal_basal_metabolism	0.98365662
61	MP0002272_abnormal_nervous_system	0.96869909
62	MP0006276_abnormal_autonomic_nervous	0.96504603
63	MP0001905_abnormal_dopamine_level	0.95479399
64	MP0008875_abnormal_xenobiotic_pharmacok	0.95043098
65	MP0003183_abnormal_peptide_metabolism	0.94638248
66	MP0003950_abnormal_plasma_membrane	0.94608570
67	MP0005195_abnormal_posterior_eye	0.93091943
68	MP0001968_abnormal_touch/_nociception	0.91910749
69	MP0009745_abnormal_behavioral_response	0.90880403
70	MP0005332_abnormal_amino_acid	0.89997071
71	MP0009697_abnormal_copulation	0.89763337
72	MP0004142_abnormal_muscle_tone	0.86885517
73	MP0001286_abnormal_eye_development	0.85549590
74	MP0000015_abnormal_ear_pigmentation	0.85208641
75	MP0003806_abnormal_nucleotide_metabolis	0.84560769
76	MP0005075_abnormal_melanosome_morpholog	0.83674715
77	MP0004885_abnormal_endolymph	0.83111161
78	MP0001944_abnormal_pancreas_morphology	0.82202682
79	MP0001765_abnormal_ion_homeostasis	0.81595344
80	MP0000427_abnormal_hair_cycle	0.80461475
81	MP0001440_abnormal_grooming_behavior	0.78619913
82	MP0005391_vision/eye_phenotype	0.76355296
83	MP0000569_abnormal_digit_pigmentation	0.75798112
84	MP0002095_abnormal_skin_pigmentation	0.75111772
85	MP0003077_abnormal_cell_cycle	0.74984186
86	MP0005623_abnormal_meninges_morphology	0.74097780
87	MP0005389_reproductive_system_phenotype	0.70176159
88	MP0008872_abnormal_physiological_respon	0.69900122
89	MP0002572_abnormal_emotion/affect_behav	0.69836239
90	MP0001919_abnormal_reproductive_system	0.69795476
91	MP0003136_yellow_coat_color	0.69578546
92	MP0000534_abnormal_ureter_morphology	0.69272541
93	MP0005319_abnormal_enzyme/_coenzyme	0.68999063
94	MP0001986_abnormal_taste_sensitivity	0.68744660
95	MP0001501_abnormal_sleep_pattern	0.65758058
96	MP0002882_abnormal_neuron_morphology	0.65691843
97	MP0000631_abnormal_neuroendocrine_gland	0.64887902
98	MP0002736_abnormal_nociception_after	0.64081391
99	MP0002697_abnormal_eye_size	0.63432487
100	MP0002752_abnormal_somatic_nervous	0.61424579

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	4.95252665
2	Tubulointerstitial nephritis (HP:0001970)	4.64253875
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.37855708
4	Absent/shortened dynein arms (HP:0200106)	4.37855708
5	Stridor (HP:0010307)	3.78964563
6	Severe visual impairment (HP:0001141)	3.70596374
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.62169575
8	Attenuation of retinal blood vessels (HP:0007843)	3.58264013
9	Bony spicule pigmentary retinopathy (HP:0007737)	3.37117304
10	Nephronophthisis (HP:0000090)	3.29436430
11	Abnormal respiratory epithelium morphology (HP:0012253)	3.26562202
12	Abnormal respiratory motile cilium morphology (HP:0005938)	3.26562202
13	Abnormal ciliary motility (HP:0012262)	3.26171046
14	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.22788915
15	Abnormality of lateral ventricle (HP:0030047)	3.19259612
16	Abnormal respiratory motile cilium physiology (HP:0012261)	3.16633011
17	Abnormality of the parathyroid morphology (HP:0011766)	3.11317864
18	Abnormal sex determination (HP:0012244)	3.03889256
19	Sex reversal (HP:0012245)	3.03889256
20	Cone-rod dystrophy (HP:0000548)	3.01619350
21	Hypomagnesemia (HP:0002917)	2.97002491
22	Abnormality of macular pigmentation (HP:0008002)	2.93970426
23	Type II lissencephaly (HP:0007260)	2.78442124
24	Abnormality of the renal medulla (HP:0100957)	2.73265227
25	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.67833143
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.54582926
27	Impulsivity (HP:0100710)	2.52765997
28	Tubulointerstitial abnormality (HP:0001969)	2.51792289
29	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.49269561
30	Decreased central vision (HP:0007663)	2.46065649
31	Rhinitis (HP:0012384)	2.44654502
32	Insulin-resistant diabetes mellitus (HP:0000831)	2.43273413
33	Abnormality of midbrain morphology (HP:0002418)	2.40070627
34	Molar tooth sign on MRI (HP:0002419)	2.40070627
35	Abnormality of the femoral head (HP:0003368)	2.35312216
36	Cerebellar dysplasia (HP:0007033)	2.35203925
37	Tetany (HP:0001281)	2.34845575
38	Mitral stenosis (HP:0001718)	2.32151445
39	Abnormality of magnesium homeostasis (HP:0004921)	2.31474339
40	Hypoplastic ischia (HP:0003175)	2.30125228
41	Hyperkalemia (HP:0002153)	2.28051670
42	Pancreatic fibrosis (HP:0100732)	2.27359660
43	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.26124963
44	Increased circulating renin level (HP:0000848)	2.24286586
45	Abnormality of the preputium (HP:0100587)	2.23598732
46	Hypsarrhythmia (HP:0002521)	2.21281426
47	Disproportionate short-trunk short stature (HP:0003521)	2.21226428
48	Abnormal drinking behavior (HP:0030082)	2.19818089
49	Polydipsia (HP:0001959)	2.19818089
50	Glycosuria (HP:0003076)	2.16681925
51	Abnormality of urine glucose concentration (HP:0011016)	2.16681925
52	Midline defect of the nose (HP:0004122)	2.16307177
53	Epileptiform EEG discharges (HP:0011182)	2.15803760
54	Sloping forehead (HP:0000340)	2.15716631
55	Flat capital femoral epiphysis (HP:0003370)	2.15135994
56	Tachypnea (HP:0002789)	2.14516326
57	Abnormality of the ischium (HP:0003174)	2.13669701
58	Nasal polyposis (HP:0100582)	2.12991168
59	Retinal dysplasia (HP:0007973)	2.12515674
60	EEG with generalized epileptiform discharges (HP:0011198)	2.11366973
61	Chromsome breakage (HP:0040012)	2.10758857
62	Pigmentary retinal degeneration (HP:0001146)	2.10717035
63	Meckel diverticulum (HP:0002245)	2.10555826
64	Intellectual disability, moderate (HP:0002342)	2.08914655
65	Bell-shaped thorax (HP:0001591)	2.08546358
66	Infertility (HP:0000789)	2.08381921
67	Congenital malformation of the right heart (HP:0011723)	2.08073011
68	Double outlet right ventricle (HP:0001719)	2.08073011
69	Abnormality of the ileum (HP:0001549)	2.04582854
70	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03324695
71	Renal Fanconi syndrome (HP:0001994)	2.00582829
72	Abnormality of femoral epiphyses (HP:0006499)	1.99204218
73	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.99204218
74	Amelogenesis imperfecta (HP:0000705)	1.98194238
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95295575
76	Chronic bronchitis (HP:0004469)	1.95143780
77	Hyperthyroidism (HP:0000836)	1.94942203
78	Menstrual irregularities (HP:0000858)	1.94911196
79	Myokymia (HP:0002411)	1.93256241
80	Male pseudohermaphroditism (HP:0000037)	1.91438414
81	Congenital hepatic fibrosis (HP:0002612)	1.91159568
82	Asymmetric septal hypertrophy (HP:0001670)	1.90182238
83	True hermaphroditism (HP:0010459)	1.90155397
84	Hypergonadotropic hypogonadism (HP:0000815)	1.89884458
85	Diaphragmatic weakness (HP:0009113)	1.89879756
86	Abnormality of cochlea (HP:0000375)	1.89006446
87	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87988429
88	Tubular atrophy (HP:0000092)	1.87279697
89	Male infertility (HP:0003251)	1.86897907
90	Abnormality of the anterior horn cell (HP:0006802)	1.85790754
91	Degeneration of anterior horn cells (HP:0002398)	1.85790754
92	Neoplasm of the adrenal cortex (HP:0100641)	1.85678565
93	Spastic tetraparesis (HP:0001285)	1.85224335
94	Pancreatic cysts (HP:0001737)	1.84286959
95	Spontaneous abortion (HP:0005268)	1.83401489
96	Progressive sensorineural hearing impairment (HP:0000408)	1.83064667
97	Abnormality of chromosome stability (HP:0003220)	1.82008664
98	Chronic sinusitis (HP:0011109)	1.81148301
99	Hypophosphatemic rickets (HP:0004912)	1.81134373
100	Abnormality of the pubic bones (HP:0003172)	1.80029112

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.44596888
2	INSRR	4.22814685
3	PRKD3	3.76733818
4	NTRK3	3.70237097
5	PNCK	3.02333732
6	SIK2	2.67738163
7	STK39	2.67268413
8	CDC7	2.55215822
9	FRK	2.49619525
10	TESK1	2.27064824
11	WNK4	2.26274227
12	MAP3K2	2.15155832
13	MAP4K2	2.11626170
14	WEE1	2.00896448
15	PLK2	1.93855396
16	TNIK	1.78116332
17	PIK3CG	1.62653006
18	ARAF	1.61639967
19	CASK	1.53772590
20	KSR2	1.38220981
21	PTK2B	1.37522458
22	OXSR1	1.36570852
23	IRAK1	1.34846341
24	STK24	1.33893787
25	MAPK15	1.28467897
26	BCKDK	1.28028550
27	NUAK1	1.22526074
28	BMPR1B	1.17526620
29	MST4	1.16343284
30	EPHB1	1.13968732
31	BRSK2	1.12677973
32	CDK19	1.05985987
33	DDR2	1.04388175
34	BRD4	1.04142961
35	MARK3	1.02726968
36	ZAK	1.01831300
37	MAP3K4	0.99073283
38	MAP3K9	0.96349224
39	FER	0.94388091
40	NLK	0.93095934
41	STK38	0.91701617
42	SIK3	0.89534437
43	CAMK2D	0.88465951
44	FLT3	0.79392212
45	VRK2	0.76556847
46	CAMK2G	0.75429390
47	WNK3	0.74573080
48	PRKCG	0.73034581
49	MAPK13	0.71962739
50	CAMK2B	0.71919109
51	CDK3	0.68033241
52	FGFR2	0.67623189
53	PINK1	0.67247429
54	NEK6	0.66286829
55	STK38L	0.61240830
56	RAF1	0.59395068
57	EPHA3	0.58119108
58	PIM2	0.55868535
59	BRAF	0.55701842
60	BRSK1	0.55696293
61	DMPK	0.54899172
62	PDK1	0.53722756
63	PKN2	0.50892852
64	MUSK	0.50091866
65	DYRK2	0.49265579
66	NEK2	0.46635538
67	CAMK2A	0.46518893
68	TAF1	0.46075619
69	MARK2	0.45574387
70	MAP3K1	0.44791259
71	TSSK6	0.42435682
72	ADRBK2	0.41661905
73	SGK494	0.41284445
74	SGK223	0.41284445
75	MAP2K6	0.40373709
76	TIE1	0.38611068
77	TYK2	0.35771806
78	PLK1	0.34286923
79	MARK1	0.34256195
80	PRKCH	0.33432588
81	PRKCZ	0.32753874
82	WNK1	0.32738498
83	GRK1	0.32173755
84	STK11	0.29396322
85	NTRK2	0.29373335
86	STK3	0.29353794
87	CAMK1	0.28720941
88	CDK7	0.28385955
89	PRKAA2	0.27917582
90	TYRO3	0.27811166
91	CHEK1	0.27051696
92	SIK1	0.25624113
93	PRKD2	0.25248065
94	CAMK1G	0.22919474
95	CDK1	0.22329330
96	CSNK1G1	0.22252679
97	PRKG1	0.21747079
98	CDK2	0.21365270
99	AKT1	0.21012090
100	PDPK1	0.20399677

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Folate biosynthesis_Homo sapiens_hsa00790	4.63904474
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.53814040
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	4.30423846
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.40497793
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.99830717
6	Butanoate metabolism_Homo sapiens_hsa00650	2.98972646
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.84544832
8	Fatty acid degradation_Homo sapiens_hsa00071	2.39376738
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06269298
10	Homologous recombination_Homo sapiens_hsa03440	1.94850229
11	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.91196881
12	Olfactory transduction_Homo sapiens_hsa04740	1.85036551
13	One carbon pool by folate_Homo sapiens_hsa00670	1.83909442
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.83759472
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.68285061
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.57587501
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.52052806
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.50904720
19	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.43243505
20	Peroxisome_Homo sapiens_hsa04146	1.37961148
21	Taste transduction_Homo sapiens_hsa04742	1.37124659
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.35017339
23	Sulfur relay system_Homo sapiens_hsa04122	1.33649087
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.32647298
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.29706775
26	Glutathione metabolism_Homo sapiens_hsa00480	1.29431786
27	Phototransduction_Homo sapiens_hsa04744	1.27452246
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.24041845
29	Basal transcription factors_Homo sapiens_hsa03022	1.14439980
30	Mismatch repair_Homo sapiens_hsa03430	1.13201817
31	Nicotine addiction_Homo sapiens_hsa05033	1.08424653
32	Proteasome_Homo sapiens_hsa03050	1.07257917
33	Circadian entrainment_Homo sapiens_hsa04713	1.06588881
34	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.00583881
35	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.00262562
36	Insulin secretion_Homo sapiens_hsa04911	0.99604545
37	Salivary secretion_Homo sapiens_hsa04970	0.97628525
38	Base excision repair_Homo sapiens_hsa03410	0.96639336
39	Huntingtons disease_Homo sapiens_hsa05016	0.96391585
40	Propanoate metabolism_Homo sapiens_hsa00640	0.95999922
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.95826162
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.95814840
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89484553
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.87798171
45	Fatty acid elongation_Homo sapiens_hsa00062	0.87767622
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87270258
47	Purine metabolism_Homo sapiens_hsa00230	0.87059122
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.86847137
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85690461
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84414051
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83221652
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.83009312
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82845653
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79472211
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75454977
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.75224315
57	Metabolic pathways_Homo sapiens_hsa01100	0.74689302
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73814330
59	Oocyte meiosis_Homo sapiens_hsa04114	0.73705754
60	RNA transport_Homo sapiens_hsa03013	0.73366646
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70366431
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69204594
63	Parkinsons disease_Homo sapiens_hsa05012	0.67770735
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66778835
65	ABC transporters_Homo sapiens_hsa02010	0.66322523
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66291430
67	Serotonergic synapse_Homo sapiens_hsa04726	0.65450268
68	Morphine addiction_Homo sapiens_hsa05032	0.64661601
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63849638
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.63670426
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60844103
72	Type II diabetes mellitus_Homo sapiens_hsa04930	0.60827216
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.59148598
74	GABAergic synapse_Homo sapiens_hsa04727	0.56563967
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55977869
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55872169
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.55584225
78	Mineral absorption_Homo sapiens_hsa04978	0.54912283
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53143175
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53045898
81	Renin secretion_Homo sapiens_hsa04924	0.49645744
82	DNA replication_Homo sapiens_hsa03030	0.48501110
83	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.48063850
84	Retinol metabolism_Homo sapiens_hsa00830	0.46568814
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.46053928
86	Long-term depression_Homo sapiens_hsa04730	0.45457993
87	RNA polymerase_Homo sapiens_hsa03020	0.45071230
88	Caffeine metabolism_Homo sapiens_hsa00232	0.42570039
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.41157753
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.40177353
91	Alzheimers disease_Homo sapiens_hsa05010	0.39431777
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.39227604
93	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.38688219
94	RNA degradation_Homo sapiens_hsa03018	0.38295364
95	Amphetamine addiction_Homo sapiens_hsa05031	0.36407603
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34107961
97	Cholinergic synapse_Homo sapiens_hsa04725	0.32159757
98	Pancreatic secretion_Homo sapiens_hsa04972	0.32125028
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30509193
100	Regulation of autophagy_Homo sapiens_hsa04140	0.29991955

PTPN20CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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