PTPN23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of NFAT protein import into nucleus (GO:0051532)4.25552683
2negative regulation of erythrocyte differentiation (GO:0045647)4.09692955
3mannose metabolic process (GO:0006013)3.71203664
4cytoskeletal anchoring at plasma membrane (GO:0007016)3.67952968
5pre-miRNA processing (GO:0031054)3.65163113
6COPI coating of Golgi vesicle (GO:0048205)3.64124476
7Golgi transport vesicle coating (GO:0048200)3.64124476
8cell-cell junction maintenance (GO:0045217)3.57978678
9protein retention in ER lumen (GO:0006621)3.53351635
10NLS-bearing protein import into nucleus (GO:0006607)3.51924392
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43074625
12plasma membrane repair (GO:0001778)3.39846238
13negative regulation of fatty acid transport (GO:2000192)3.33278053
14apoptotic cell clearance (GO:0043277)3.31371933
15polarized epithelial cell differentiation (GO:0030859)3.30796584
16negative regulation of cell size (GO:0045792)3.25799611
17positive regulation of histone deacetylation (GO:0031065)3.22140371
18barbed-end actin filament capping (GO:0051016)3.22135222
19cell adhesion mediated by integrin (GO:0033627)3.21090839
20adherens junction assembly (GO:0034333)3.20636455
21regulation of hippo signaling (GO:0035330)3.19379530
22heterochromatin organization (GO:0070828)3.16826397
23regulation of extracellular matrix disassembly (GO:0010715)3.15412517
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11022837
25regulation of integrin activation (GO:0033623)3.08306578
26endodermal cell differentiation (GO:0035987)3.07801119
27regulation of glucose import in response to insulin stimulus (GO:2001273)3.03163114
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.02343742
29cell-substrate junction assembly (GO:0007044)3.01553390
30semaphorin-plexin signaling pathway (GO:0071526)3.00850842
31paraxial mesoderm development (GO:0048339)2.99982031
32planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99807201
33protein heterotrimerization (GO:0070208)2.98506409
34regulation of cholesterol homeostasis (GO:2000188)2.95101457
35hippo signaling (GO:0035329)2.94422189
36regulation of ARF protein signal transduction (GO:0032012)2.94292549
37insulin-like growth factor receptor signaling pathway (GO:0048009)2.92181757
38apoptotic process involved in morphogenesis (GO:0060561)2.90706024
39positive regulation of p38MAPK cascade (GO:1900745)2.89075673
40regulation of translational fidelity (GO:0006450)2.86901711
41stress fiber assembly (GO:0043149)2.85410436
42wound healing, spreading of epidermal cells (GO:0035313)2.85398794
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83429621
44activation of MAPKKK activity (GO:0000185)2.83195105
45establishment of apical/basal cell polarity (GO:0035089)2.79729180
46regulation of p38MAPK cascade (GO:1900744)2.79680987
47positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77368902
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77245847
49positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75619322
50modulation by symbiont of host cellular process (GO:0044068)2.75199233
51cytoplasmic mRNA processing body assembly (GO:0033962)2.73889238
52axon extension involved in axon guidance (GO:0048846)2.73238130
53neuron projection extension involved in neuron projection guidance (GO:1902284)2.73238130
54cell-substrate adherens junction assembly (GO:0007045)2.73053029
55focal adhesion assembly (GO:0048041)2.73053029
56endothelial cell chemotaxis (GO:0035767)2.72646789
57regulation of clathrin-mediated endocytosis (GO:2000369)2.69946047
58protein targeting to plasma membrane (GO:0072661)2.69352264
59positive regulation of SMAD protein import into nucleus (GO:0060391)2.68850135
60atrioventricular valve morphogenesis (GO:0003181)2.68719607
61vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.68034473
62regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67443633
63positive regulation of receptor recycling (GO:0001921)2.65709914
64skin morphogenesis (GO:0043589)2.65199845
65macroautophagy (GO:0016236)2.64778127
66maternal placenta development (GO:0001893)2.63976292
67cell junction maintenance (GO:0034331)2.61942130
68negative regulation of catenin import into nucleus (GO:0035414)2.58619979
69protein localization to endosome (GO:0036010)2.57421259
70regulation of tight junction assembly (GO:2000810)2.56393329
71modulation by virus of host morphology or physiology (GO:0019048)2.56360066
72peptidyl-lysine dimethylation (GO:0018027)2.56131604
73intracellular estrogen receptor signaling pathway (GO:0030520)2.55948062
74regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.53595226
75endocytic recycling (GO:0032456)2.52312948
76cell volume homeostasis (GO:0006884)2.51991145
77regulation of SMAD protein import into nucleus (GO:0060390)2.51565000
78glucocorticoid receptor signaling pathway (GO:0042921)2.50916562
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49010785
80epithelial cell-cell adhesion (GO:0090136)2.48760110
81response to laminar fluid shear stress (GO:0034616)2.47777403
82modulation by virus of host process (GO:0019054)2.46742317
83cortical actin cytoskeleton organization (GO:0030866)2.46602767
84positive regulation of protein dephosphorylation (GO:0035307)2.45599818
85basement membrane organization (GO:0071711)2.44028016
86desmosome organization (GO:0002934)2.42767181
87embryonic process involved in female pregnancy (GO:0060136)2.42765491
88adhesion of symbiont to host (GO:0044406)2.42504131
89actin filament bundle assembly (GO:0051017)2.41807661
90actin filament bundle organization (GO:0061572)2.41807661
91establishment or maintenance of monopolar cell polarity (GO:0061339)2.39791353
92establishment of monopolar cell polarity (GO:0061162)2.39791353
93peptidyl-tyrosine autophosphorylation (GO:0038083)2.39166847
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.37220078
95regulation of histone H3-K27 methylation (GO:0061085)2.37086735
96regulation of posttranscriptional gene silencing (GO:0060147)2.36207996
97regulation of gene silencing by miRNA (GO:0060964)2.36207996
98regulation of gene silencing by RNA (GO:0060966)2.36207996
99response to fluid shear stress (GO:0034405)2.35178530
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.35014412
101cerebellar Purkinje cell layer development (GO:0021680)2.34927132
102positive regulation of RNA splicing (GO:0033120)2.34722152
103sodium ion export (GO:0071436)2.33930197
104positive regulation of nuclease activity (GO:0032075)2.33707112
105layer formation in cerebral cortex (GO:0021819)2.33125020
106stress granule assembly (GO:0034063)2.32681559
107Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32510742
108glucose 6-phosphate metabolic process (GO:0051156)2.32294840
109cell migration in hindbrain (GO:0021535)2.31837973
110negative regulation of viral release from host cell (GO:1902187)2.31405109
111regulation of ARF GTPase activity (GO:0032312)2.30676116
112establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.30189428
113apoptotic process involved in development (GO:1902742)2.30037813
114signal complex assembly (GO:0007172)2.29637680
115cortical cytoskeleton organization (GO:0030865)2.29550873
116negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.29077005
117response to parathyroid hormone (GO:0071107)2.28628018
118establishment of nucleus localization (GO:0040023)2.28494021
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.27545804
120hemidesmosome assembly (GO:0031581)2.26361848
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26173216
122low-density lipoprotein particle clearance (GO:0034383)2.24694351
123cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23000494
124L-alpha-amino acid transmembrane transport (GO:1902475)2.22447845
125Rho protein signal transduction (GO:0007266)2.22442799
126positive regulation of fibroblast migration (GO:0010763)2.22038499
127placenta blood vessel development (GO:0060674)2.21975914
128G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.21728326
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.21334091
130branching involved in mammary gland duct morphogenesis (GO:0060444)2.21136478
131regulation of extracellular matrix organization (GO:1903053)2.20934732
132regulation of nucleobase-containing compound transport (GO:0032239)2.20814033
133gastrulation with mouth forming second (GO:0001702)2.20353513
134collagen fibril organization (GO:0030199)2.19169144
135cell migration involved in sprouting angiogenesis (GO:0002042)2.18729775
136RNA stabilization (GO:0043489)2.17974262
137mRNA stabilization (GO:0048255)2.17974262
138* regulation of early endosome to late endosome transport (GO:2000641)2.17840024
139regulation of chromatin binding (GO:0035561)2.17798924
140negative regulation of smooth muscle cell migration (GO:0014912)2.17403975
141adherens junction organization (GO:0034332)2.17191062
142vascular endothelial growth factor signaling pathway (GO:0038084)2.17151158
143convergent extension (GO:0060026)2.16530431
144activation of Rac GTPase activity (GO:0032863)2.16009776
145positive regulation of myotube differentiation (GO:0010831)2.15855303
146intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.15224557
147regulation of apoptotic process involved in morphogenesis (GO:1902337)2.14820695
148labyrinthine layer blood vessel development (GO:0060716)2.14691248
149endoplasmic reticulum unfolded protein response (GO:0030968)2.14561880
150activation of JUN kinase activity (GO:0007257)2.14423710
151dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.13822739
152negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.13263715
153regulation of nuclease activity (GO:0032069)2.13069267
154regulation of cholesterol biosynthetic process (GO:0045540)2.12937401
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.12638999
156neural tube closure (GO:0001843)2.11917561
157regulation of establishment of planar polarity (GO:0090175)2.11722149
158substrate adhesion-dependent cell spreading (GO:0034446)2.10520999
159cellular response to fluid shear stress (GO:0071498)2.10264577
160craniofacial suture morphogenesis (GO:0097094)2.08598953
161chondrocyte proliferation (GO:0035988)2.08183231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.72942068
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.47162869
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.39185610
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77395968
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56428516
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.54171063
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.53929271
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50266906
9KDM2B_26808549_Chip-Seq_DND41_Human2.49882585
10MYC_22102868_ChIP-Seq_BL_Human2.30957873
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26372387
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24639489
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.24216610
14ZFP281_27345836_Chip-Seq_ESCs_Mouse2.21940402
15KDM2B_26808549_Chip-Seq_K562_Human2.16258499
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14014394
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13199840
18* LXR_22292898_ChIP-Seq_THP-1_Human2.05744216
19TCF7_22412390_ChIP-Seq_EML_Mouse2.04081131
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.00868011
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98907641
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97290280
23P300_27058665_Chip-Seq_ZR-75-30cells_Human1.95413689
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91948956
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83886540
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.82646788
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82537382
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.78981792
29RACK7_27058665_Chip-Seq_MCF-7_Human1.77819348
30* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77209836
31VDR_21846776_ChIP-Seq_THP-1_Human1.76277545
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75668506
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63701047
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62402095
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62096945
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61714265
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57718613
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57341806
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55279979
40CLOCK_20551151_ChIP-Seq_293T_Human1.53473649
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51849746
42* ATF3_27146783_Chip-Seq_COLON_Human1.50931940
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.49022940
44CREB1_26743006_Chip-Seq_LNCaP_Human1.46767598
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.46607342
46TP53_22127205_ChIP-Seq_IMR90_Human1.45490007
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.44218759
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39931753
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38920786
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37810783
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36557942
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35484599
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31590117
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31586860
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31586860
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31586860
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30950254
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28819520
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28212641
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25641032
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23924582
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23141674
63CTCF_27219007_Chip-Seq_Bcells_Human1.21981837
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.21800042
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20209558
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19417901
67NCOR1_26117541_ChIP-Seq_K562_Human1.19396203
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.17587263
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.16789513
70NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16231086
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15969341
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15536994
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.14975293
74* TP53_23651856_ChIP-Seq_MEFs_Mouse1.14723611
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14545595
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13757607
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13440150
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12392667
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11611186
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11553055
81ZNF263_19887448_ChIP-Seq_K562_Human1.11491036
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11408274
83* SPI1_23127762_ChIP-Seq_K562_Human1.10719807
84MAF_26560356_Chip-Seq_TH2_Human1.09985234
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09729767
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.09638872
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.08377447
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07767689
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.07546260
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07493177
91DROSHA_22980978_ChIP-Seq_HELA_Human1.07409115
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07395403
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.07324484
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.05862536
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.05368221
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05219020
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04524438
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04284268
99SMC4_20622854_ChIP-Seq_HELA_Human1.04121734
100RARB_27405468_Chip-Seq_BRAIN_Mouse1.03592297
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03286203
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02756050
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02751381
104UTX_26944678_Chip-Seq_JUKART_Human1.01979035
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01914809
106KLF5_25053715_ChIP-Seq_YYC3_Human1.00408389
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.00214560
108TBX20_22328084_ChIP-Seq_HEART_Mouse1.00214560
109KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99832149
110BCOR_27268052_Chip-Seq_Bcells_Human0.99587396
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99092441
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99036007
113TP63_22573176_ChIP-Seq_HFKS_Human0.98696768
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98647006
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98488890
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98128139
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98063451
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97912613
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97719968
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97645271
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97125215
122GATA1_19941826_ChIP-Seq_K562_Human0.96968836
123* MAF_26560356_Chip-Seq_TH1_Human0.96354678
124VDR_24763502_ChIP-Seq_THP-1_Human0.96189574
125* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95631912
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95459699
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94710787
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94623197
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93875149
130* P68_20966046_ChIP-Seq_HELA_Human0.93872968
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93731157
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93575742
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93237683
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92886458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.36488336
2MP0000569_abnormal_digit_pigmentation3.53412420
3MP0005076_abnormal_cell_differentiation3.16563806
4MP0008438_abnormal_cutaneous_collagen3.00957531
5MP0005623_abnormal_meninges_morphology3.00763215
6MP0005451_abnormal_body_composition2.91562334
7MP0000678_abnormal_parathyroid_gland2.88201965
8MP0005409_darkened_coat_color2.72993306
9MP0009278_abnormal_bone_marrow2.71030164
10MP0010352_gastrointestinal_tract_polyps2.69268356
11MP0003566_abnormal_cell_adhesion2.56837209
12MP0004858_abnormal_nervous_system2.56281140
13MP0000733_abnormal_muscle_development2.28858595
14MP0009840_abnormal_foam_cell2.28363253
15MP0002653_abnormal_ependyma_morphology2.27218528
16MP0003091_abnormal_cell_migration2.22415834
17MP0003283_abnormal_digestive_organ2.21761031
18MP0008260_abnormal_autophagy2.20840187
19MP0003303_peritoneal_inflammation2.17642977
20MP0001849_ear_inflammation2.04522718
21MP0008961_abnormal_basal_metabolism2.04425831
22MP0005257_abnormal_intraocular_pressure2.03340757
23MP0003300_gastrointestinal_ulcer1.98950762
24MP0003172_abnormal_lysosome_physiology1.92043508
25MP0010234_abnormal_vibrissa_follicle1.86685894
26MP0010030_abnormal_orbit_morphology1.81178419
27MP0002249_abnormal_larynx_morphology1.80477030
28MP0003279_aneurysm1.79129666
29MP0001958_emphysema1.76207095
30MP0005023_abnormal_wound_healing1.69740120
31MP0003045_fibrosis1.65382006
32MP0004272_abnormal_basement_membrane1.54588722
33MP0000003_abnormal_adipose_tissue1.49877757
34MP0002796_impaired_skin_barrier1.48827748
35MP0005275_abnormal_skin_tensile1.48627557
36MP0004233_abnormal_muscle_weight1.42882679
37MP0010307_abnormal_tumor_latency1.42353052
38MP0004197_abnormal_fetal_growth/weight/1.39239893
39MP0003115_abnormal_respiratory_system1.38774070
40MP0003436_decreased_susceptibility_to1.37525894
41MP0003191_abnormal_cellular_cholesterol1.36008615
42MP0000428_abnormal_craniofacial_morphol1.35951070
43MP0001348_abnormal_lacrimal_gland1.35805167
44MP0000537_abnormal_urethra_morphology1.33225674
45MP0004510_myositis1.30408053
46MP0000750_abnormal_muscle_regeneration1.29691670
47MP0005508_abnormal_skeleton_morphology1.27916659
48MP0005666_abnormal_adipose_tissue1.26057848
49MP0000534_abnormal_ureter_morphology1.26039753
50MP0002697_abnormal_eye_size1.24607287
51MP0001299_abnormal_eye_distance/1.23661928
52MP0003385_abnormal_body_wall1.21865764
53MP0002877_abnormal_melanocyte_morpholog1.20159296
54MP0002089_abnormal_postnatal_growth/wei1.18982780
55MP0002084_abnormal_developmental_patter1.18350712
56MP0002925_abnormal_cardiovascular_devel1.16132706
57MP0005503_abnormal_tendon_morphology1.14287164
58MP0005375_adipose_tissue_phenotype1.12949005
59MP0004859_abnormal_synaptic_plasticity1.11425806
60MP0003119_abnormal_digestive_system1.09244419
61MP0000579_abnormal_nail_morphology1.08930468
62MP0005501_abnormal_skin_physiology1.07692186
63MP0002896_abnormal_bone_mineralization1.07197113
64MP0000858_altered_metastatic_potential1.07151476
65MP0000767_abnormal_smooth_muscle1.06733297
66MP0000566_synostosis1.05688079
67MP0003634_abnormal_glial_cell1.04637899
68MP0003942_abnormal_urinary_system1.04215123
69MP0001915_intracranial_hemorrhage1.02529873
70MP0002085_abnormal_embryonic_tissue1.01664412
71MP0004087_abnormal_muscle_fiber1.01055028
72MP0004185_abnormal_adipocyte_glucose1.00998887
73MP0002086_abnormal_extraembryonic_tissu0.99896313
74MP0003935_abnormal_craniofacial_develop0.99231106
75MP0002254_reproductive_system_inflammat0.98961272
76MP0000013_abnormal_adipose_tissue0.97624987
77MP0009780_abnormal_chondrocyte_physiolo0.96091697
78MP0009053_abnormal_anal_canal0.95246840
79MP0000747_muscle_weakness0.93489396
80* MP0003984_embryonic_growth_retardation0.93450613
81* MP0002088_abnormal_embryonic_growth/wei0.93188108
82MP0010630_abnormal_cardiac_muscle0.93052301
83MP0003448_altered_tumor_morphology0.91563109
84MP0006138_congestive_heart_failure0.91223520
85MP0005058_abnormal_lysosome_morphology0.91088652
86MP0002234_abnormal_pharynx_morphology0.90468203
87* MP0001672_abnormal_embryogenesis/_devel0.90400196
88* MP0005380_embryogenesis_phenotype0.90400196
89MP0000467_abnormal_esophagus_morphology0.89601240
90MP0003453_abnormal_keratinocyte_physiol0.89423988
91MP0000432_abnormal_head_morphology0.89236765
92MP0000751_myopathy0.89143414
93MP0004947_skin_inflammation0.88006307
94MP0004381_abnormal_hair_follicle0.87866245
95MP0002932_abnormal_joint_morphology0.87529297
96MP0002092_abnormal_eye_morphology0.87097114
97MP0000604_amyloidosis0.86612608
98MP0009384_cardiac_valve_regurgitation0.86527183
99MP0005621_abnormal_cell_physiology0.85801681
100MP0002116_abnormal_craniofacial_bone0.85194729
101MP0003755_abnormal_palate_morphology0.85129415
102MP0001730_embryonic_growth_arrest0.84996365
103MP0003879_abnormal_hair_cell0.84046351
104MP0005670_abnormal_white_adipose0.82920749
105MP0008770_decreased_survivor_rate0.82234103
106MP0004264_abnormal_extraembryonic_tissu0.81993001
107MP0002168_other_aberrant_phenotype0.81795701
108MP0009931_abnormal_skin_appearance0.81623767
109MP0000759_abnormal_skeletal_muscle0.80537680
110MP0009672_abnormal_birth_weight0.79884497
111MP0000266_abnormal_heart_morphology0.78784082
112MP0009703_decreased_birth_body0.78725606
113MP0002282_abnormal_trachea_morphology0.78561443
114MP0003183_abnormal_peptide_metabolism0.78376433
115MP0003123_paternal_imprinting0.77862938
116MP0005197_abnormal_uvea_morphology0.76801879
117MP0001614_abnormal_blood_vessel0.76611323
118MP0001697_abnormal_embryo_size0.76360068
119MP0003861_abnormal_nervous_system0.76047800
120MP0002269_muscular_atrophy0.75795660
121MP0000350_abnormal_cell_proliferation0.75412010
122MP0010368_abnormal_lymphatic_system0.75064893
123MP0001216_abnormal_epidermal_layer0.74683190
124MP0000681_abnormal_thyroid_gland0.74269972
125MP0005248_abnormal_Harderian_gland0.74060569
126MP0002108_abnormal_muscle_morphology0.72318988
127MP0003075_altered_response_to0.71875126
128MP0005390_skeleton_phenotype0.71402913
129MP0002998_abnormal_bone_remodeling0.71224523
130MP0003329_amyloid_beta_deposits0.70421885
131MP0002909_abnormal_adrenal_gland0.69482432
132MP0002060_abnormal_skin_morphology0.69413780
133MP0003122_maternal_imprinting0.68810488
134MP0002111_abnormal_tail_morphology0.68074157
135MP0000762_abnormal_tongue_morphology0.65730061
136MP0002933_joint_inflammation0.64389830
137MP0008569_lethality_at_weaning0.64197952
138MP0000920_abnormal_myelination0.61482701
139MP0002113_abnormal_skeleton_development0.61041085
140MP0001533_abnormal_skeleton_physiology0.59668670
141MP0003795_abnormal_bone_structure0.57207274

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.93100562
2Protrusio acetabuli (HP:0003179)3.91466031
3Obstructive sleep apnea (HP:0002870)3.85839001
4Cerebral aneurysm (HP:0004944)3.85111017
5Premature rupture of membranes (HP:0001788)3.39283887
6Upper limb amyotrophy (HP:0009129)3.23055443
7Distal upper limb amyotrophy (HP:0007149)3.23055443
8Broad face (HP:0000283)2.99678091
9Hyperacusis (HP:0010780)2.84279662
10Hand muscle atrophy (HP:0009130)2.83598269
11Genu recurvatum (HP:0002816)2.79429294
12Turricephaly (HP:0000262)2.73300946
13Ankle contracture (HP:0006466)2.71120774
14Ulnar bowing (HP:0003031)2.62197032
15Bladder diverticulum (HP:0000015)2.59662195
16Increased variability in muscle fiber diameter (HP:0003557)2.56067709
17Mitral valve prolapse (HP:0001634)2.50405737
18Dilatation of the ascending aorta (HP:0005111)2.39423057
19Aneurysm (HP:0002617)2.34748125
20Distal lower limb muscle weakness (HP:0009053)2.31898463
21Atrophic scars (HP:0001075)2.30837439
22Broad metatarsal (HP:0001783)2.29787502
23Cerebral inclusion bodies (HP:0100314)2.29481734
24Supranuclear gaze palsy (HP:0000605)2.29182094
25Abnormality of the Achilles tendon (HP:0005109)2.26734911
26Cervical subluxation (HP:0003308)2.25947979
27Macroorchidism (HP:0000053)2.25912569
28Stridor (HP:0010307)2.25553101
29Renal duplication (HP:0000075)2.25544411
30Neurofibrillary tangles (HP:0002185)2.23407566
31Abnormality of the lower motor neuron (HP:0002366)2.23004019
32Bowel diverticulosis (HP:0005222)2.22724953
33Peritonitis (HP:0002586)2.21915961
34Abnormality of skeletal muscle fiber size (HP:0012084)2.21412118
35Mitral regurgitation (HP:0001653)2.19992390
36Increased connective tissue (HP:0009025)2.17712498
37Neoplasm of the heart (HP:0100544)2.12957211
38Abnormality of the astrocytes (HP:0100707)2.11359952
39Astrocytoma (HP:0009592)2.11359952
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.08333455
41Aortic aneurysm (HP:0004942)2.07801575
42J-shaped sella turcica (HP:0002680)2.05520498
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03499801
44Short 4th metacarpal (HP:0010044)2.03499801
45Heterotopia (HP:0002282)2.02179877
46Difficulty climbing stairs (HP:0003551)1.98756069
47Biconcave vertebral bodies (HP:0004586)1.97132189
48Wrist flexion contracture (HP:0001239)1.96188172
49Broad thumb (HP:0011304)1.96013016
50Long toe (HP:0010511)1.95325828
51Increased density of long bones (HP:0006392)1.95057134
52Aortic dissection (HP:0002647)1.92212644
53Hemorrhage of the eye (HP:0011885)1.91309804
54Advanced eruption of teeth (HP:0006288)1.91150976
55Mildly elevated creatine phosphokinase (HP:0008180)1.90991984
56Elfin facies (HP:0004428)1.90638986
57Pointed chin (HP:0000307)1.88956035
58Distal lower limb amyotrophy (HP:0008944)1.88736028
59Deviation of the hallux (HP:0010051)1.87529233
60Urethral obstruction (HP:0000796)1.87035046
61Abnormality of the distal phalanx of the thumb (HP:0009617)1.86954576
62Subacute progressive viral hepatitis (HP:0006572)1.86478519
63Lymphangioma (HP:0100764)1.86450537
64Radial bowing (HP:0002986)1.85973776
65Flat acetabular roof (HP:0003180)1.85018782
66Nuclear cataract (HP:0100018)1.84459784
67Bowing of the arm (HP:0006488)1.84293177
68Bowed forearm bones (HP:0003956)1.84293177
69Hallux valgus (HP:0001822)1.83516091
70Lower limb amyotrophy (HP:0007210)1.83140696
71Abnormality of the thoracic spine (HP:0100711)1.82932601
72Premature skin wrinkling (HP:0100678)1.82377357
73Hyperparathyroidism (HP:0000843)1.81176680
74Blue sclerae (HP:0000592)1.80259964
75Disproportionate tall stature (HP:0001519)1.79986481
76Fragile skin (HP:0001030)1.79231579
77Dysostosis multiplex (HP:0000943)1.79073308
78Thin ribs (HP:0000883)1.78447836
79Difficulty running (HP:0009046)1.78253315
80Vascular tortuosity (HP:0004948)1.76820517
81Insomnia (HP:0100785)1.76472406
82Short nail (HP:0001799)1.75789389
83Renovascular hypertension (HP:0100817)1.74795520
84Natal tooth (HP:0000695)1.74545245
85Narrow palate (HP:0000189)1.74436882
86Myopathic facies (HP:0002058)1.73256238
87Scapular winging (HP:0003691)1.72168408
88Arterial tortuosity (HP:0005116)1.71496593
89Ependymoma (HP:0002888)1.71107905
90Deep venous thrombosis (HP:0002625)1.71077654
91Patellar dislocation (HP:0002999)1.70694734
92Arnold-Chiari malformation (HP:0002308)1.70071996
93Bronchomalacia (HP:0002780)1.69927942
94Type 1 muscle fiber predominance (HP:0003803)1.67786900
95Thin bony cortex (HP:0002753)1.67619418
96Hyperextensible skin (HP:0000974)1.67480037
97Emphysema (HP:0002097)1.66609392
98Uterine leiomyosarcoma (HP:0002891)1.65700390
99Leiomyosarcoma (HP:0100243)1.65700390
100Generalized amyotrophy (HP:0003700)1.65638473
101Atelectasis (HP:0100750)1.64316188
102Tibial bowing (HP:0002982)1.63565326
103Pseudobulbar signs (HP:0002200)1.63532031
104Joint laxity (HP:0001388)1.63414703
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62181681
106Achilles tendon contracture (HP:0001771)1.62101372
107Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61810744
108Neuronal loss in central nervous system (HP:0002529)1.60922061
109Ankyloglossia (HP:0010296)1.60029788
110Polygenic inheritance (HP:0010982)1.59971624
111Long palpebral fissure (HP:0000637)1.59958424
112Enlarged penis (HP:0000040)1.59951440
113Peripheral hypomyelination (HP:0007182)1.59081917
114Abnormality of the 4th metacarpal (HP:0010012)1.58331654
115Abnormality of dentin (HP:0010299)1.58289503
116Mucopolysacchariduria (HP:0008155)1.58178485
117Urinary glycosaminoglycan excretion (HP:0003541)1.58178485
118Axonal loss (HP:0003447)1.57988452
119Flat cornea (HP:0007720)1.57966069
120Broad long bones (HP:0005622)1.57615662
121Hyporeflexia of lower limbs (HP:0002600)1.57592277
122Vertebral fusion (HP:0002948)1.57236092
123Hypercortisolism (HP:0001578)1.57220088
124Broad phalanges of the hand (HP:0009768)1.57120190
125Joint stiffness (HP:0001387)1.56796137
126Hypoplastic ischia (HP:0003175)1.56731028
127Genetic anticipation (HP:0003743)1.56517320
128Spinal rigidity (HP:0003306)1.56409040
129Annular pancreas (HP:0001734)1.55680221
130Coxa vara (HP:0002812)1.55566476
131Reticulocytosis (HP:0001923)1.55452150
132Hypoventilation (HP:0002791)1.55406052
133Vertebral compression fractures (HP:0002953)1.55036877
134Wormian bones (HP:0002645)1.54604591
135Elbow flexion contracture (HP:0002987)1.54109316
136Asymmetric septal hypertrophy (HP:0001670)1.53802609
137Absent frontal sinuses (HP:0002688)1.53475758
138Abnormality of the radial head (HP:0003995)1.53460921
139Overriding aorta (HP:0002623)1.53287847
140Trigonocephaly (HP:0000243)1.53129108
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.53012132
142Overgrowth (HP:0001548)1.52243461
143Fused cervical vertebrae (HP:0002949)1.52127591
144Camptodactyly of toe (HP:0001836)1.51836016
145Selective tooth agenesis (HP:0001592)1.50700999
146Abnormality of the fingertips (HP:0001211)1.50527121
147Long eyelashes (HP:0000527)1.50434480
148Protruding ear (HP:0000411)1.50191606
149Metaphyseal cupping (HP:0003021)1.50104881
150Frequent falls (HP:0002359)1.50082397
151Dislocated radial head (HP:0003083)1.49582083
152Neonatal short-limb short stature (HP:0008921)1.49008250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.57740083
2TRIB33.77226745
3SMG13.25591692
4PRPF4B3.05863918
5ERN12.94969943
6ICK2.72677274
7PDGFRA2.43429879
8MAP3K102.43404924
9TTN2.40420505
10PKN22.33637923
11RIPK12.24771802
12DDR22.10666887
13EEF2K2.07268178
14BMX2.02969986
15TYRO32.01695889
16SIK11.92682712
17IRAK31.90846625
18PTK61.87490889
19LATS21.85170399
20LATS11.77022508
21SIK21.76743711
22BRD41.75838876
23CAMK1G1.73634919
24MTOR1.64333045
25PTK21.58400929
26MAP3K91.48450024
27PRKD31.47054781
28CAMK1D1.46143456
29TAOK11.46139154
30ALK1.42187983
31EPHA21.38507294
32PAK61.34054662
33EPHB11.32552155
34PAK41.26150530
35PAK21.21103456
36MST1R1.20690284
37MAP2K31.18605527
38PDGFRB1.18004253
39TESK11.17696893
40MAP3K31.13482335
41TAOK21.12153047
42DMPK1.11657266
43MARK21.09708517
44MAP3K111.02698071
45LMTK21.02114467
46MAP3K131.01362696
47MAP3K10.96518537
48PRKD20.95877404
49CDC42BPA0.92980736
50STK380.90398428
51PDPK10.89384979
52MAP4K10.88437040
53RIPK40.85665601
54CDK60.85556640
55KSR20.83768496
56MAP3K60.83233943
57FGFR40.82083949
58ARAF0.79328001
59EPHB20.79114347
60RET0.78720239
61FGFR10.78706894
62WNK10.78633906
63NME20.78563131
64CHUK0.78056506
65NTRK10.75866129
66PAK30.75540001
67MAP3K70.73166408
68PRKCH0.71389992
69DYRK1B0.70229671
70NEK20.70087299
71LRRK20.68759703
72RPS6KC10.66027207
73RPS6KL10.66027207
74TNK20.65696983
75IRAK20.65596883
76SCYL20.65303942
77ERBB20.64842504
78FER0.63380410
79MAPK120.61695316
80EPHA30.61129224
81DAPK20.60880980
82MAPK110.60579583
83STK100.58997388
84BRAF0.58709689
85MAPK70.58036138
86KSR10.57983770
87CAMKK10.57360882
88STK30.56981511
89RPS6KA20.56857774
90TBK10.54530792
91NEK10.52792711
92PRKG20.51642491
93PRKD10.51342299
94ZAP700.50215370
95SIK30.49659525
96HCK0.46537347
97NTRK20.45805752
98UHMK10.45672908
99CAMK40.45661222
100FGFR20.45200213
101MAPK10.45110836
102PDK10.44976736
103PTK2B0.44844605
104STK110.44662219
105MAP3K20.44357617
106MAP2K20.44112194
107MAP3K80.43372793
108RPS6KA60.43338409
109MAPK100.42544675
110MET0.42442298
111TYK20.41762364
112RPS6KA10.41691846
113AKT20.41502962
114MOS0.41185957
115PNCK0.40683254
116CDK90.40489809
117IRAK40.39466739
118DAPK30.39298052
119RPS6KA40.39036281
120SRC0.38315985
121GSK3A0.38093403
122MAPK80.38003468
123JAK10.37795361
124ROCK20.37042034
125SGK30.36957646
126EGFR0.36590017
127FGFR30.35713275
128FGR0.35670399
129MAP3K140.34930112
130MAPKAPK20.34377351
131INSR0.34133043
132ROCK10.34059816
133HIPK20.34008369
134MARK30.33993112
135CDK70.33785738
136GSK3B0.32365291
137JAK30.32327438
138CDK40.31353313
139MAPK90.30882531

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.19802505
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00224354
3Chronic myeloid leukemia_Homo sapiens_hsa052201.84124262
4mTOR signaling pathway_Homo sapiens_hsa041501.75774801
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71206647
6Proteoglycans in cancer_Homo sapiens_hsa052051.70331676
7Notch signaling pathway_Homo sapiens_hsa043301.66263407
8Focal adhesion_Homo sapiens_hsa045101.56773547
9Prion diseases_Homo sapiens_hsa050201.52323899
10ECM-receptor interaction_Homo sapiens_hsa045121.50493032
11Adherens junction_Homo sapiens_hsa045201.47769617
12MicroRNAs in cancer_Homo sapiens_hsa052061.44332177
13Type II diabetes mellitus_Homo sapiens_hsa049301.44217038
14Bladder cancer_Homo sapiens_hsa052191.43332669
15Glioma_Homo sapiens_hsa052141.41235500
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41188851
17Neurotrophin signaling pathway_Homo sapiens_hsa047221.40794161
18Amoebiasis_Homo sapiens_hsa051461.39804351
19Small cell lung cancer_Homo sapiens_hsa052221.36340529
20Hippo signaling pathway_Homo sapiens_hsa043901.34890865
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30997818
22Lysine degradation_Homo sapiens_hsa003101.29984345
23Dorso-ventral axis formation_Homo sapiens_hsa043201.28935360
24Basal cell carcinoma_Homo sapiens_hsa052171.28106207
25Endometrial cancer_Homo sapiens_hsa052131.28102119
26VEGF signaling pathway_Homo sapiens_hsa043701.27869455
27Renal cell carcinoma_Homo sapiens_hsa052111.24630583
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24523781
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21209874
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20024983
31Thyroid cancer_Homo sapiens_hsa052161.19528957
32Estrogen signaling pathway_Homo sapiens_hsa049151.16824880
33Hedgehog signaling pathway_Homo sapiens_hsa043401.15111960
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.15061315
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14350642
36Dilated cardiomyopathy_Homo sapiens_hsa054141.14199009
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11475597
38Pancreatic cancer_Homo sapiens_hsa052121.10166521
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09928113
40Non-small cell lung cancer_Homo sapiens_hsa052231.08530174
41Acute myeloid leukemia_Homo sapiens_hsa052211.07831471
42ErbB signaling pathway_Homo sapiens_hsa040121.06756518
43Long-term potentiation_Homo sapiens_hsa047201.06376036
44Colorectal cancer_Homo sapiens_hsa052101.04204299
45Osteoclast differentiation_Homo sapiens_hsa043801.02202600
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02136358
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01889170
48Insulin resistance_Homo sapiens_hsa049310.99594636
49Viral myocarditis_Homo sapiens_hsa054160.99496119
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.99077400
51Toxoplasmosis_Homo sapiens_hsa051450.98780336
52TNF signaling pathway_Homo sapiens_hsa046680.96278248
53Fructose and mannose metabolism_Homo sapiens_hsa000510.95588780
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95251245
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.95176197
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95142014
57Shigellosis_Homo sapiens_hsa051310.92805188
58Hepatitis C_Homo sapiens_hsa051600.91823879
59B cell receptor signaling pathway_Homo sapiens_hsa046620.90859266
60GnRH signaling pathway_Homo sapiens_hsa049120.90108173
61Rap1 signaling pathway_Homo sapiens_hsa040150.89866417
62Prostate cancer_Homo sapiens_hsa052150.89789012
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89072148
64Prolactin signaling pathway_Homo sapiens_hsa049170.88104752
65Axon guidance_Homo sapiens_hsa043600.87914733
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86644814
67Gap junction_Homo sapiens_hsa045400.86088264
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.84382310
69HIF-1 signaling pathway_Homo sapiens_hsa040660.84204562
70Endocytosis_Homo sapiens_hsa041440.84049173
71MAPK signaling pathway_Homo sapiens_hsa040100.83386711
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.83266569
73Insulin signaling pathway_Homo sapiens_hsa049100.82906378
74Apoptosis_Homo sapiens_hsa042100.82852585
75Leishmaniasis_Homo sapiens_hsa051400.82816475
76TGF-beta signaling pathway_Homo sapiens_hsa043500.82508942
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82199995
78Choline metabolism in cancer_Homo sapiens_hsa052310.81639678
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81566664
80Pentose phosphate pathway_Homo sapiens_hsa000300.81428951
81Pathways in cancer_Homo sapiens_hsa052000.80625557
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80612238
83Tight junction_Homo sapiens_hsa045300.80037267
84HTLV-I infection_Homo sapiens_hsa051660.79845439
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79666897
86Lysosome_Homo sapiens_hsa041420.79375799
87Galactose metabolism_Homo sapiens_hsa000520.79286743
88Melanogenesis_Homo sapiens_hsa049160.78384052
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77103388
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75422616
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.73730628
92Vibrio cholerae infection_Homo sapiens_hsa051100.73726603
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.73054074
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72816669
95AMPK signaling pathway_Homo sapiens_hsa041520.71856532
96Salmonella infection_Homo sapiens_hsa051320.71661970
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71253274
98Melanoma_Homo sapiens_hsa052180.70949097
99Wnt signaling pathway_Homo sapiens_hsa043100.70055481
100Hepatitis B_Homo sapiens_hsa051610.69563208
101Protein digestion and absorption_Homo sapiens_hsa049740.68625032
102FoxO signaling pathway_Homo sapiens_hsa040680.68395931
103Synaptic vesicle cycle_Homo sapiens_hsa047210.68229132
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66589139
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65668341
106Oxytocin signaling pathway_Homo sapiens_hsa049210.65141054
107Thyroid hormone synthesis_Homo sapiens_hsa049180.64997071
108Glucagon signaling pathway_Homo sapiens_hsa049220.64607635
109Tuberculosis_Homo sapiens_hsa051520.64305990
110Inositol phosphate metabolism_Homo sapiens_hsa005620.63465364
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62507989
112Platelet activation_Homo sapiens_hsa046110.62168304
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60738812
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60523181
115Influenza A_Homo sapiens_hsa051640.60393877
116T cell receptor signaling pathway_Homo sapiens_hsa046600.58425449
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57416856
118Gastric acid secretion_Homo sapiens_hsa049710.56461552
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56086494
120Bile secretion_Homo sapiens_hsa049760.52874682

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »