PTPN2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.93214203
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.12900632
3negative regulation of T cell differentiation in thymus (GO:0033085)6.08272595
4retinal cone cell development (GO:0046549)5.81551211
5axoneme assembly (GO:0035082)5.64759397
6DNA deamination (GO:0045006)5.05091163
7cilium movement (GO:0003341)4.75747728
8retinal rod cell development (GO:0046548)4.64891456
9regulation of T cell receptor signaling pathway (GO:0050856)4.29841484
10epithelial cilium movement (GO:0003351)4.19043942
11negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.03248789
12cell wall macromolecule metabolic process (GO:0044036)3.92067786
13Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86957004
14synapsis (GO:0007129)3.82264982
15cytidine deamination (GO:0009972)3.80275910
16cytidine metabolic process (GO:0046087)3.80275910
17cytidine catabolic process (GO:0006216)3.80275910
18positive regulation of uterine smooth muscle contraction (GO:0070474)3.74151702
19negative regulation of T cell receptor signaling pathway (GO:0050860)3.70401750
20actin nucleation (GO:0045010)3.70003713
21negative T cell selection (GO:0043383)3.64468106
22negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.63768221
23pyrimidine ribonucleoside catabolic process (GO:0046133)3.59563544
24positive regulation of gamma-delta T cell activation (GO:0046645)3.59481881
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57621382
26proteasome assembly (GO:0043248)3.55426140
27developmental pigmentation (GO:0048066)3.54521644
28histone mRNA catabolic process (GO:0071044)3.49426570
29regulation of gamma-delta T cell differentiation (GO:0045586)3.48331242
30ubiquinone metabolic process (GO:0006743)3.48016364
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.38068394
32axonemal dynein complex assembly (GO:0070286)3.36359695
33resolution of meiotic recombination intermediates (GO:0000712)3.27184935
34replication fork processing (GO:0031297)3.22483661
35photoreceptor cell maintenance (GO:0045494)3.21333667
36negative regulation of macrophage differentiation (GO:0045650)3.19913756
37regulation of cilium movement (GO:0003352)3.19852482
38mating behavior (GO:0007617)3.19691296
39negative regulation of T cell apoptotic process (GO:0070233)3.17522173
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14952729
41cytochrome complex assembly (GO:0017004)3.14687906
42regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.12460391
43serotonin receptor signaling pathway (GO:0007210)3.11889679
44rRNA modification (GO:0000154)3.10287557
45negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.10048033
46negative regulation of thymocyte apoptotic process (GO:0070244)3.09341004
47ncRNA 3-end processing (GO:0043628)3.09097677
48negative thymic T cell selection (GO:0045060)3.08530513
49positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.07269741
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07251355
51regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.05148711
52kynurenine metabolic process (GO:0070189)3.03638679
53purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.02366767
54tryptophan catabolic process (GO:0006569)3.02216109
55indole-containing compound catabolic process (GO:0042436)3.02216109
56indolalkylamine catabolic process (GO:0046218)3.02216109
57cellular ketone body metabolic process (GO:0046950)3.02007510
58DNA double-strand break processing (GO:0000729)2.97700468
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.97513796
60positive T cell selection (GO:0043368)2.96330530
61positive regulation of natural killer cell mediated immunity (GO:0002717)2.93770205
62positive regulation of mitotic sister chromatid separation (GO:1901970)2.93151013
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93151013
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93151013
65regulation of gamma-delta T cell activation (GO:0046643)2.90938921
66protein K11-linked deubiquitination (GO:0035871)2.88775785
67regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.87917556
68positive thymic T cell selection (GO:0045059)2.87717378
69respiratory chain complex IV assembly (GO:0008535)2.86800024
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.86371046
71indolalkylamine metabolic process (GO:0006586)2.84237762
72negative regulation by host of viral transcription (GO:0043922)2.83818182
73positive regulation of calcium-mediated signaling (GO:0050850)2.78057033
74adenosine metabolic process (GO:0046085)2.75711553
75negative regulation of T cell differentiation (GO:0045581)2.75486162
76positive regulation of T cell apoptotic process (GO:0070234)2.73277669
77regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.72904788
78motile cilium assembly (GO:0044458)2.72017870
79water-soluble vitamin biosynthetic process (GO:0042364)2.70785795
80ketone body metabolic process (GO:1902224)2.70213943
81tryptophan metabolic process (GO:0006568)2.69138082
82response to pheromone (GO:0019236)2.68387703
83protein complex biogenesis (GO:0070271)2.63313164
84regulation of alpha-beta T cell proliferation (GO:0046640)2.60720620
85positive regulation of lymphocyte apoptotic process (GO:0070230)2.60715105
86regulation of thymocyte apoptotic process (GO:0070243)2.59598584
87positive regulation of gluconeogenesis (GO:0045722)2.58884235
88regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.57241420
89regulation of uterine smooth muscle contraction (GO:0070472)2.56396257
90rhodopsin mediated signaling pathway (GO:0016056)2.55908500
91prenylation (GO:0097354)2.55538603
92protein prenylation (GO:0018342)2.55538603
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51723669
94regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50621955
95regulation of activation of Janus kinase activity (GO:0010533)2.49527840
96negative regulation of nitric-oxide synthase activity (GO:0051001)2.47988897
97pseudouridine synthesis (GO:0001522)2.47714604
98positive regulation of protein homooligomerization (GO:0032464)2.47002856
99mitochondrial respiratory chain complex assembly (GO:0033108)2.46239744
100regulation of calcium-mediated signaling (GO:0050848)2.45059318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32132026
2VDR_22108803_ChIP-Seq_LS180_Human4.17959474
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85712481
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.94702488
5ZNF274_21170338_ChIP-Seq_K562_Hela2.83634092
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76559882
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.43343788
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42583383
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19219381
10IGF1R_20145208_ChIP-Seq_DFB_Human2.17434835
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09188539
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06226391
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02280727
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93956289
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92820858
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91168103
17TAF15_26573619_Chip-Seq_HEK293_Human1.90416611
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90149180
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.88544875
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.84214091
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.77562845
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74803064
23GBX2_23144817_ChIP-Seq_PC3_Human1.74539108
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72921105
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.71681536
26BCAT_22108803_ChIP-Seq_LS180_Human1.70370933
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69361683
28EWS_26573619_Chip-Seq_HEK293_Human1.69173980
29ER_23166858_ChIP-Seq_MCF-7_Human1.67738970
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64624375
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.64517317
32GATA3_26560356_Chip-Seq_TH2_Human1.63749044
33FUS_26573619_Chip-Seq_HEK293_Human1.62922307
34CBP_20019798_ChIP-Seq_JUKART_Human1.61923103
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61923103
36MYB_26560356_Chip-Seq_TH2_Human1.61453951
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59718981
38TP53_22573176_ChIP-Seq_HFKS_Human1.57679881
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.53232213
40NANOG_19829295_ChIP-Seq_ESCs_Human1.52678468
41SOX2_19829295_ChIP-Seq_ESCs_Human1.52678468
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51385063
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49752354
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49196083
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45826456
46GATA3_27048872_Chip-Seq_THYMUS_Human1.41174132
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40893822
48VDR_23849224_ChIP-Seq_CD4+_Human1.39966165
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38774913
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38088561
51P300_19829295_ChIP-Seq_ESCs_Human1.37349619
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37103458
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33754949
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.33349739
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33349739
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32884974
57AR_21572438_ChIP-Seq_LNCaP_Human1.32289541
58ERG_20517297_ChIP-Seq_VCAP_Human1.31774785
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.30556724
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29811231
61TCF4_22108803_ChIP-Seq_LS180_Human1.28949756
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.28295484
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.27950963
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27948731
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27110562
66CDX2_22108803_ChIP-Seq_LS180_Human1.25677803
67AR_20517297_ChIP-Seq_VCAP_Human1.24418406
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23058278
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21909908
70FOXP3_21729870_ChIP-Seq_TREG_Human1.19567708
71ELK1_19687146_ChIP-ChIP_HELA_Human1.18958294
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18581655
73HTT_18923047_ChIP-ChIP_STHdh_Human1.17634981
74RBPJ_21746931_ChIP-Seq_IB4_Human1.17169600
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15523047
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15114663
77PHF8_20622853_ChIP-Seq_HELA_Human1.14159317
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.12492281
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.11845196
80STAT3_23295773_ChIP-Seq_U87_Human1.11533374
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.11000841
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.09926765
83RUNX_20019798_ChIP-Seq_JUKART_Human1.09910598
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09501981
85ETV1_20927104_ChIP-Seq_GIST48_Human1.09291411
86SMRT_27268052_Chip-Seq_Bcells_Human1.08123731
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07755300
88NCOR_22424771_ChIP-Seq_293T_Human1.07496264
89NFYB_21822215_ChIP-Seq_K562_Human1.07312077
90HOXB7_26014856_ChIP-Seq_BT474_Human1.06976062
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06805528
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06143778
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04559463
94TP53_16413492_ChIP-PET_HCT116_Human1.04218860
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03921638
96SMAD4_21799915_ChIP-Seq_A2780_Human1.03719228
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02825198
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02779863
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02634036
100P53_22387025_ChIP-Seq_ESCs_Mouse1.01813197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.35493564
2MP0010386_abnormal_urinary_bladder3.18286534
3MP0000569_abnormal_digit_pigmentation3.13955604
4MP0008877_abnormal_DNA_methylation3.00716544
5MP0005174_abnormal_tail_pigmentation2.97113311
6MP0005671_abnormal_response_to2.90844529
7MP0008057_abnormal_DNA_replication2.74856089
8MP0001835_abnormal_antigen_presentation2.38355242
9MP0002138_abnormal_hepatobiliary_system2.37340664
10MP0001188_hyperpigmentation2.35057656
11MP0003763_abnormal_thymus_physiology2.31753957
12MP0009379_abnormal_foot_pigmentation2.27575678
13MP0005075_abnormal_melanosome_morpholog2.27002504
14MP0003806_abnormal_nucleotide_metabolis2.23009026
15MP0005551_abnormal_eye_electrophysiolog2.09891552
16MP0001800_abnormal_humoral_immune2.05000275
17MP0002837_dystrophic_cardiac_calcinosis2.04088139
18MP0004147_increased_porphyrin_level2.03649038
19MP0002148_abnormal_hypersensitivity_rea2.00104128
20MP0003866_abnormal_defecation1.98312488
21MP0000015_abnormal_ear_pigmentation1.97305972
22MP0008875_abnormal_xenobiotic_pharmacok1.97217584
23MP0002102_abnormal_ear_morphology1.88174024
24MP0008007_abnormal_cellular_replicative1.76544685
25MP0000372_irregular_coat_pigmentation1.76426426
26MP0003950_abnormal_plasma_membrane1.74107951
27MP0002160_abnormal_reproductive_system1.69264491
28MP0003195_calcinosis1.63876572
29MP0009785_altered_susceptibility_to1.63396075
30MP0001968_abnormal_touch/_nociception1.60465258
31MP0005000_abnormal_immune_tolerance1.58614663
32MP0002166_altered_tumor_susceptibility1.55814299
33MP0002723_abnormal_immune_serum1.52017656
34MP0002420_abnormal_adaptive_immunity1.50805836
35MP0001819_abnormal_immune_cell1.46907085
36MP0000383_abnormal_hair_follicle1.46453878
37MP0003786_premature_aging1.46326942
38MP0005084_abnormal_gallbladder_morpholo1.46277956
39MP0005645_abnormal_hypothalamus_physiol1.44200697
40MP0002452_abnormal_antigen_presenting1.41991143
41MP0005389_reproductive_system_phenotype1.37997671
42MP0002405_respiratory_system_inflammati1.36868831
43MP0001873_stomach_inflammation1.34771458
44MP0000716_abnormal_immune_system1.31654673
45MP0002398_abnormal_bone_marrow1.29306926
46MP0009333_abnormal_splenocyte_physiolog1.26928805
47MP0002638_abnormal_pupillary_reflex1.24523584
48MP0005646_abnormal_pituitary_gland1.24100586
49MP0002163_abnormal_gland_morphology1.22601555
50MP0008872_abnormal_physiological_respon1.21640125
51MP0005360_urolithiasis1.20338019
52MP0005266_abnormal_metabolism1.19718370
53MP0005025_abnormal_response_to1.18257148
54MP0001845_abnormal_inflammatory_respons1.15541296
55MP0002693_abnormal_pancreas_physiology1.14340551
56MP0002735_abnormal_chemical_nociception1.14086996
57MP0010678_abnormal_skin_adnexa1.13779400
58MP0005310_abnormal_salivary_gland1.13199712
59MP0005253_abnormal_eye_physiology1.13103561
60MP0002006_tumorigenesis1.10456313
61MP0005379_endocrine/exocrine_gland_phen1.09591471
62MP0003045_fibrosis1.07352875
63MP0003172_abnormal_lysosome_physiology1.07324680
64MP0004145_abnormal_muscle_electrophysio1.06072927
65MP0002933_joint_inflammation1.03344553
66MP0006036_abnormal_mitochondrial_physio1.02429027
67MP0005387_immune_system_phenotype1.01158195
68MP0001790_abnormal_immune_system1.01158195
69MP0002095_abnormal_skin_pigmentation1.01001692
70MP0002254_reproductive_system_inflammat0.98487284
71MP0000538_abnormal_urinary_bladder0.98338229
72MP0005377_hearing/vestibular/ear_phenot0.98036050
73MP0003878_abnormal_ear_physiology0.98036050
74MP0000689_abnormal_spleen_morphology0.97530890
75MP0009643_abnormal_urine_homeostasis0.93356901
76MP0003252_abnormal_bile_duct0.93282250
77MP0000703_abnormal_thymus_morphology0.93265351
78MP0002429_abnormal_blood_cell0.93126750
79MP0008873_increased_physiological_sensi0.87778861
80MP0001764_abnormal_homeostasis0.87506634
81MP0001661_extended_life_span0.84239727
82MP0005464_abnormal_platelet_physiology0.82009049
83MP0002136_abnormal_kidney_physiology0.81618935
84MP0002653_abnormal_ependyma_morphology0.80603870
85MP0004215_abnormal_myocardial_fiber0.80376855
86MP0005410_abnormal_fertilization0.79870525
87MP0000685_abnormal_immune_system0.78190552
88MP0002722_abnormal_immune_system0.77469148
89MP0002019_abnormal_tumor_incidence0.76737962
90MP0009764_decreased_sensitivity_to0.76481192
91MP0002876_abnormal_thyroid_physiology0.76143333
92MP0005083_abnormal_biliary_tract0.75287409
93MP0000230_abnormal_systemic_arterial0.75144749
94MP0002909_abnormal_adrenal_gland0.74457145
95MP0001542_abnormal_bone_strength0.73854343
96MP0001929_abnormal_gametogenesis0.73812116
97MP0005085_abnormal_gallbladder_physiolo0.72469664
98MP0001905_abnormal_dopamine_level0.72351676
99MP0001119_abnormal_female_reproductive0.71010447
100MP0004957_abnormal_blastocyst_morpholog0.69912956

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.31382596
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.98303063
3Absent/shortened dynein arms (HP:0200106)5.98303063
4Abnormal rod and cone electroretinograms (HP:0008323)4.75498491
5Abnormality of B cell number (HP:0010975)4.30032252
6Chronic hepatic failure (HP:0100626)4.19751698
7Abnormal ciliary motility (HP:0012262)4.07209203
8Abnormal respiratory epithelium morphology (HP:0012253)3.98471181
9Abnormal respiratory motile cilium morphology (HP:0005938)3.98471181
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.68912288
11B lymphocytopenia (HP:0010976)3.64887513
12Abnormal respiratory motile cilium physiology (HP:0012261)3.62890896
13Pancreatic cysts (HP:0001737)3.45539095
14Bronchiectasis (HP:0002110)3.44857775
15Recurrent bronchitis (HP:0002837)3.33522994
163-Methylglutaconic aciduria (HP:0003535)3.27865492
17Attenuation of retinal blood vessels (HP:0007843)3.16961257
18Abnormality of T cell number (HP:0011839)3.11831329
19IgG deficiency (HP:0004315)3.07656678
20Bony spicule pigmentary retinopathy (HP:0007737)3.01780667
21Pancreatic fibrosis (HP:0100732)2.96634797
22IgM deficiency (HP:0002850)2.91655348
23True hermaphroditism (HP:0010459)2.89675043
24Bronchitis (HP:0012387)2.89109564
25Severe combined immunodeficiency (HP:0004430)2.87562840
26Autoimmune hemolytic anemia (HP:0001890)2.84587478
27Rhinitis (HP:0012384)2.81227508
28T lymphocytopenia (HP:0005403)2.77030688
29Neoplasm of the tracheobronchial system (HP:0100552)2.67255259
30Abnormality of T cells (HP:0002843)2.67145407
31Thyroiditis (HP:0100646)2.60188571
32Partial agenesis of the corpus callosum (HP:0001338)2.59594877
33Constricted visual fields (HP:0001133)2.58102734
34Congenital stationary night blindness (HP:0007642)2.57814141
35Combined immunodeficiency (HP:0005387)2.56781550
36Abnormality of midbrain morphology (HP:0002418)2.55152813
37Molar tooth sign on MRI (HP:0002419)2.55152813
38Ependymoma (HP:0002888)2.52844784
39Abnormality of T cell physiology (HP:0011840)2.51456315
40Increased CSF lactate (HP:0002490)2.50427859
41Acute necrotizing encephalopathy (HP:0006965)2.40030227
42Abnormal biliary tract physiology (HP:0012439)2.37566068
43Bile duct proliferation (HP:0001408)2.37566068
44Abnormality of the astrocytes (HP:0100707)2.37542665
45Astrocytoma (HP:0009592)2.37542665
46Hepatocellular necrosis (HP:0001404)2.35797442
47Mitochondrial inheritance (HP:0001427)2.34834793
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.33693620
49Abnormality of the prostate (HP:0008775)2.33508880
50Abnormal mitochondria in muscle tissue (HP:0008316)2.33358362
51Recurrent sinusitis (HP:0011108)2.30716885
52Eosinophilia (HP:0001880)2.29893614
53Autoimmune thrombocytopenia (HP:0001973)2.26600905
54Chronic bronchitis (HP:0004469)2.24508210
55Chronic sinusitis (HP:0011109)2.23672018
56Alveolar cell carcinoma (HP:0006519)2.23508431
57Stomach cancer (HP:0012126)2.16085686
58Hypoproteinemia (HP:0003075)2.14683489
59Progressive macrocephaly (HP:0004481)2.14157737
60Carpal bone hypoplasia (HP:0001498)2.13233997
61Increased IgM level (HP:0003496)2.11034204
62Elevated erythrocyte sedimentation rate (HP:0003565)2.10037298
63IgA deficiency (HP:0002720)2.09746224
64Joint swelling (HP:0001386)2.08304328
65Abnormality of eosinophils (HP:0001879)2.06485539
66Decreased central vision (HP:0007663)2.04081959
67Hepatic necrosis (HP:0002605)2.03338533
68Type 2 muscle fiber atrophy (HP:0003554)2.01909141
69Cone-rod dystrophy (HP:0000548)1.99249293
70Cystic liver disease (HP:0006706)1.96696981
71Abnormality of the renal cortex (HP:0011035)1.96008459
72Abolished electroretinogram (ERG) (HP:0000550)1.94061305
73Prominent nose (HP:0000448)1.92208388
74Glioma (HP:0009733)1.89383464
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83282402
76Abnormality of alanine metabolism (HP:0010916)1.83282402
77Hyperalaninemia (HP:0003348)1.83282402
78Clubbing of toes (HP:0100760)1.82950056
79Recurrent otitis media (HP:0000403)1.82007686
80Renal cortical cysts (HP:0000803)1.80409301
81Rhabdomyosarcoma (HP:0002859)1.80137509
82Pulmonary infiltrates (HP:0002113)1.79719016
83Nephronophthisis (HP:0000090)1.79231560
84High pitched voice (HP:0001620)1.76335320
85Granulocytopenia (HP:0001913)1.75727504
86Pancytopenia (HP:0001876)1.75307584
87Male pseudohermaphroditism (HP:0000037)1.74941983
88Chest pain (HP:0100749)1.74618614
89Optic disc pallor (HP:0000543)1.74319397
90Neoplasm of striated muscle (HP:0009728)1.70221806
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.70104831
92Tubular atrophy (HP:0000092)1.69991409
93Panhypogammaglobulinemia (HP:0003139)1.68453038
94Acute encephalopathy (HP:0006846)1.67985830
95Sloping forehead (HP:0000340)1.66867950
96Infertility (HP:0000789)1.65151257
97Small epiphyses (HP:0010585)1.64951510
98Abnormality of the renal collecting system (HP:0004742)1.63696193
99Chronic diarrhea (HP:0002028)1.63605755
100Meckel diverticulum (HP:0002245)1.62820388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.72266146
2EIF2AK33.63507812
3MST43.51608059
4MAP3K123.48510823
5TXK3.43613091
6KDR2.99927696
7STK162.87628281
8NUAK12.38321172
9BMPR22.29258686
10ADRBK22.28472942
11IKBKB1.96210817
12GRK11.83040592
13VRK21.80356106
14STK391.77557515
15CDC71.75264804
16ZAK1.74596362
17PINK11.69951198
18ITK1.63171314
19TEC1.54675946
20TESK21.51955087
21BUB11.50796658
22WNK41.49845190
23OXSR11.45116044
24MAPK111.43525585
25TAOK31.38295571
26IKBKE1.34584812
27PRKCQ1.33397148
28PIK3CG1.28653378
29MUSK1.26250317
30MAPKAPK31.24755383
31TRIM281.16980945
32TLK11.16613628
33WNK31.16176415
34VRK11.10836762
35SYK1.08539371
36BMPR1B1.07586800
37BRSK21.06574281
38GRK71.00678703
39BLK0.97737852
40LIMK10.97272674
41BCR0.96484107
42MYLK0.92076173
43ADRBK10.91791445
44ZAP700.90187917
45MAP4K10.88504150
46BCKDK0.86495563
47RPS6KA40.82837876
48NLK0.76546882
49CSF1R0.75341100
50TSSK60.74886761
51CSNK1G10.74473457
52TYK20.74218922
53LCK0.73648277
54PRKCI0.73578708
55NTRK30.72352404
56TTK0.71694409
57TRPM70.70830972
58EIF2AK10.70391847
59MAP4K20.69743815
60CSK0.66994529
61FES0.66281403
62PRKCE0.64755205
63CSNK1G30.63840971
64PLK40.62152352
65CHUK0.61213344
66ARAF0.59006445
67LYN0.57948976
68IRAK10.57561868
69CSNK1A1L0.57091287
70RPS6KA50.56691918
71STK100.56403277
72MKNK20.55480272
73OBSCN0.55480027
74LATS10.55325254
75SCYL20.54953402
76JAK30.52167713
77INSRR0.50109507
78CAMKK20.46311066
79MAP3K90.45301723
80STK30.44447949
81ABL10.44421149
82ERBB20.44198221
83BTK0.43760314
84ATR0.41653507
85HCK0.40600470
86NME10.40532178
87MELK0.40250061
88PAK30.39637868
89EGFR0.37674307
90PIM10.36668540
91RPS6KB20.35432736
92PLK30.34934716
93TIE10.34858290
94CSNK1A10.33356510
95RAF10.32896873
96STK38L0.32256286
97GRK50.30872249
98STK110.29744975
99PRKCA0.29283231
100MAPKAPK20.28674821

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.96723406
2Proteasome_Homo sapiens_hsa030503.42271233
3Phototransduction_Homo sapiens_hsa047443.33931457
4Protein export_Homo sapiens_hsa030603.05798933
5Autoimmune thyroid disease_Homo sapiens_hsa053202.26395694
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13843143
7T cell receptor signaling pathway_Homo sapiens_hsa046602.08099055
8Allograft rejection_Homo sapiens_hsa053302.07592204
9Oxidative phosphorylation_Homo sapiens_hsa001902.06723065
10Graft-versus-host disease_Homo sapiens_hsa053322.05260194
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04520779
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99851424
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.97786422
14Fanconi anemia pathway_Homo sapiens_hsa034601.95852891
15Parkinsons disease_Homo sapiens_hsa050121.91943607
16Hematopoietic cell lineage_Homo sapiens_hsa046401.81922026
17Homologous recombination_Homo sapiens_hsa034401.75700204
18One carbon pool by folate_Homo sapiens_hsa006701.73224425
19Type I diabetes mellitus_Homo sapiens_hsa049401.69269939
20Antigen processing and presentation_Homo sapiens_hsa046121.68685278
21Huntingtons disease_Homo sapiens_hsa050161.59938068
22RNA polymerase_Homo sapiens_hsa030201.54458605
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54285117
24Asthma_Homo sapiens_hsa053101.49854280
25Linoleic acid metabolism_Homo sapiens_hsa005911.49612244
26Basal transcription factors_Homo sapiens_hsa030221.47667611
27Nitrogen metabolism_Homo sapiens_hsa009101.44589883
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42416825
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37884191
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35899196
31Tryptophan metabolism_Homo sapiens_hsa003801.35182065
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34058624
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28278494
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26349224
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23970579
36Selenocompound metabolism_Homo sapiens_hsa004501.22561552
37Alzheimers disease_Homo sapiens_hsa050101.19993760
38Sulfur metabolism_Homo sapiens_hsa009201.14975451
39Caffeine metabolism_Homo sapiens_hsa002321.14662919
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.14590055
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11120807
42Taste transduction_Homo sapiens_hsa047421.04713790
43Rheumatoid arthritis_Homo sapiens_hsa053231.03960974
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03400241
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99735584
46RNA degradation_Homo sapiens_hsa030180.98520133
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.98175409
48Purine metabolism_Homo sapiens_hsa002300.95686244
49Measles_Homo sapiens_hsa051620.90332661
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89502579
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.89381453
52Butanoate metabolism_Homo sapiens_hsa006500.87655825
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87610364
54Viral myocarditis_Homo sapiens_hsa054160.83835533
55Olfactory transduction_Homo sapiens_hsa047400.78654524
56Pyrimidine metabolism_Homo sapiens_hsa002400.75053433
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74179775
58Chemical carcinogenesis_Homo sapiens_hsa052040.73086981
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73002381
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70994580
61Peroxisome_Homo sapiens_hsa041460.69852612
62Retinol metabolism_Homo sapiens_hsa008300.68057165
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65191862
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64745091
65Serotonergic synapse_Homo sapiens_hsa047260.64151602
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60980864
67African trypanosomiasis_Homo sapiens_hsa051430.57657574
68Systemic lupus erythematosus_Homo sapiens_hsa053220.57552835
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55818858
70Propanoate metabolism_Homo sapiens_hsa006400.54300854
71Herpes simplex infection_Homo sapiens_hsa051680.54266606
72Staphylococcus aureus infection_Homo sapiens_hsa051500.50092877
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49296097
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48286890
75Arachidonic acid metabolism_Homo sapiens_hsa005900.48051702
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47352949
77Ether lipid metabolism_Homo sapiens_hsa005650.46878033
78Cardiac muscle contraction_Homo sapiens_hsa042600.46711909
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.46386270
80ABC transporters_Homo sapiens_hsa020100.45105281
81Salivary secretion_Homo sapiens_hsa049700.44066576
82p53 signaling pathway_Homo sapiens_hsa041150.43596144
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39507838
84Histidine metabolism_Homo sapiens_hsa003400.37960792
85RNA transport_Homo sapiens_hsa030130.36739026
86Non-homologous end-joining_Homo sapiens_hsa034500.36368466
87Calcium signaling pathway_Homo sapiens_hsa040200.36298693
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.34936825
89Shigellosis_Homo sapiens_hsa051310.34128495
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.33193814
91Metabolic pathways_Homo sapiens_hsa011000.30671240
92Mismatch repair_Homo sapiens_hsa034300.28423890
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.27237532
94Epstein-Barr virus infection_Homo sapiens_hsa051690.25624593
95Pancreatic secretion_Homo sapiens_hsa049720.25341456
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24358666
97Mineral absorption_Homo sapiens_hsa049780.24218169
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23968804
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23705631
100Nucleotide excision repair_Homo sapiens_hsa034200.22175267

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