PTPN2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of dendritic spine morphogenesis (GO:0061003)5.98730876
2cellular response to nitric oxide (GO:0071732)4.99563819
3adenosine metabolic process (GO:0046085)4.29381600
4L-fucose catabolic process (GO:0042355)4.02638066
5fucose catabolic process (GO:0019317)4.02638066
6L-fucose metabolic process (GO:0042354)4.02638066
7meiotic chromosome segregation (GO:0045132)3.97235984
8acrosome assembly (GO:0001675)3.85721228
9positive regulation of developmental pigmentation (GO:0048087)3.69149707
10regulation of uterine smooth muscle contraction (GO:0070472)3.66680738
11negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.65056258
12reciprocal DNA recombination (GO:0035825)3.64073700
13reciprocal meiotic recombination (GO:0007131)3.64073700
14regulation of pigment cell differentiation (GO:0050932)3.63205545
15otic vesicle formation (GO:0030916)3.58075047
16lysine metabolic process (GO:0006553)3.50818714
17lysine catabolic process (GO:0006554)3.50818714
18cell differentiation involved in metanephros development (GO:0072202)3.48585290
19regulation of mitotic spindle checkpoint (GO:1903504)3.42766306
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42766306
21tolerance induction (GO:0002507)3.41094367
22protein localization to kinetochore (GO:0034501)3.39883748
23ventricular trabecula myocardium morphogenesis (GO:0003222)3.39147337
24protein polyglutamylation (GO:0018095)3.35750721
25response to nitric oxide (GO:0071731)3.31304648
26female gonad development (GO:0008585)3.31013747
27regulation of germinal center formation (GO:0002634)3.30675984
28limb bud formation (GO:0060174)3.24278726
29positive regulation of synapse assembly (GO:0051965)3.19410562
30positive regulation of uterine smooth muscle contraction (GO:0070474)3.17405345
31aspartate family amino acid catabolic process (GO:0009068)3.17140154
32regulation of sarcomere organization (GO:0060297)3.16982292
33anterograde synaptic vesicle transport (GO:0048490)3.14716113
34RNA destabilization (GO:0050779)3.14676812
35water-soluble vitamin biosynthetic process (GO:0042364)3.12722033
36chaperone-mediated protein transport (GO:0072321)3.10450397
37peptidyl-glutamic acid modification (GO:0018200)3.09945614
38negative regulation of norepinephrine secretion (GO:0010700)3.09142892
39positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.08603409
40presynaptic membrane assembly (GO:0097105)3.05794862
41single strand break repair (GO:0000012)3.05004824
42fucosylation (GO:0036065)3.03812165
43cell proliferation in forebrain (GO:0021846)3.03718081
44somite rostral/caudal axis specification (GO:0032525)3.03276198
45heart trabecula morphogenesis (GO:0061384)3.01900891
46UDP-N-acetylglucosamine metabolic process (GO:0006047)3.00109526
47DNA damage response, detection of DNA damage (GO:0042769)2.98673927
48cell migration in hindbrain (GO:0021535)2.94881888
49transcription elongation from RNA polymerase I promoter (GO:0006362)2.94206560
50neurotransmitter-gated ion channel clustering (GO:0072578)2.91849293
51negative regulation of T cell differentiation in thymus (GO:0033085)2.90114055
52regulation of hippo signaling (GO:0035330)2.87400081
53meiosis I (GO:0007127)2.85222226
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84379257
55cerebral cortex radially oriented cell migration (GO:0021799)2.84283888
56protein deneddylation (GO:0000338)2.82454893
57negative regulation of JAK-STAT cascade (GO:0046426)2.81514110
58positive regulation of gluconeogenesis (GO:0045722)2.81266353
59termination of RNA polymerase I transcription (GO:0006363)2.80993847
60regulation of developmental pigmentation (GO:0048070)2.79348650
61vitamin biosynthetic process (GO:0009110)2.79326400
62negative regulation of DNA-dependent DNA replication (GO:2000104)2.78938584
63negative regulation of astrocyte differentiation (GO:0048712)2.77570421
64negative regulation of transcription regulatory region DNA binding (GO:2000678)2.75805556
65regulation of dendritic spine morphogenesis (GO:0061001)2.75134874
66transcription initiation from RNA polymerase I promoter (GO:0006361)2.75045626
67regulation of T-helper 1 cell differentiation (GO:0045625)2.74899999
68mismatch repair (GO:0006298)2.73972094
69cellular response to reactive nitrogen species (GO:1902170)2.72580186
70regulation of energy homeostasis (GO:2000505)2.69267067
71replication fork processing (GO:0031297)2.65417847
72somite development (GO:0061053)2.64718968
73CENP-A containing nucleosome assembly (GO:0034080)2.64266521
74DNA double-strand break processing (GO:0000729)2.64173896
75protein K6-linked ubiquitination (GO:0085020)2.62615179
76resolution of meiotic recombination intermediates (GO:0000712)2.61710911
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58660223
78negative regulation of execution phase of apoptosis (GO:1900118)2.58615501
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58548689
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.58391916
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58391916
82cardiac right ventricle morphogenesis (GO:0003215)2.58054532
83regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.57607679
84natural killer cell mediated cytotoxicity (GO:0042267)2.57254895
85natural killer cell mediated immunity (GO:0002228)2.57254895
86positive regulation of dendrite morphogenesis (GO:0050775)2.55900289
87protein K11-linked deubiquitination (GO:0035871)2.55240921
88chromatin remodeling at centromere (GO:0031055)2.54653697
89preassembly of GPI anchor in ER membrane (GO:0016254)2.54372291
90protein carboxylation (GO:0018214)2.52701506
91peptidyl-glutamic acid carboxylation (GO:0017187)2.52701506
92regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.50689103
93artery development (GO:0060840)2.50383896
94negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.49488442
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47934090
96mitochondrion transport along microtubule (GO:0047497)2.47934090
97somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47854218
98isotype switching (GO:0045190)2.47854218
99somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47854218
100regulation of T cell receptor signaling pathway (GO:0050856)2.46873007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.46769932
2VDR_22108803_ChIP-Seq_LS180_Human3.28351585
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.18940689
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.98487437
5GBX2_23144817_ChIP-Seq_PC3_Human2.86327028
6ZNF274_21170338_ChIP-Seq_K562_Hela2.71992331
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70051422
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70030719
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65462850
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.46703923
11TAF15_26573619_Chip-Seq_HEK293_Human2.36477743
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34497938
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31650758
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25947136
15FUS_26573619_Chip-Seq_HEK293_Human2.21756801
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19904095
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.18142729
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17513572
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15320497
20P300_19829295_ChIP-Seq_ESCs_Human2.14992966
21IRF1_19129219_ChIP-ChIP_H3396_Human2.00623600
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90576363
23ELK1_19687146_ChIP-ChIP_HELA_Human1.86101705
24EWS_26573619_Chip-Seq_HEK293_Human1.85891172
25IGF1R_20145208_ChIP-Seq_DFB_Human1.83898140
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81228684
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80418721
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.79400622
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.77233590
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74721319
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74707850
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73475702
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73475702
34CBP_20019798_ChIP-Seq_JUKART_Human1.71367344
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71367344
36BCAT_22108803_ChIP-Seq_LS180_Human1.64806349
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63719929
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59373745
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58705861
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56026429
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51562092
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51186450
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49677985
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.49224006
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.48301949
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41581561
47LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36809240
48ER_23166858_ChIP-Seq_MCF-7_Human1.35976340
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34406869
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.34375334
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.34209134
52SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.33290866
53MYC_18940864_ChIP-ChIP_HL60_Human1.32879790
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32035428
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.31816962
56SMAD4_21799915_ChIP-Seq_A2780_Human1.30714356
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28737855
58STAT3_23295773_ChIP-Seq_U87_Human1.28646726
59NANOG_19829295_ChIP-Seq_ESCs_Human1.26135504
60SOX2_19829295_ChIP-Seq_ESCs_Human1.26135504
61HTT_18923047_ChIP-ChIP_STHdh_Human1.25761206
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.25239355
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25165027
64P300_18555785_Chip-Seq_ESCs_Mouse1.24698526
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.23830045
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23595376
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23277940
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21459856
69P53_22387025_ChIP-Seq_ESCs_Mouse1.20918696
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20703827
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20295347
72TCF4_23295773_ChIP-Seq_U87_Human1.18833517
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18644508
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16997376
75TCF4_22108803_ChIP-Seq_LS180_Human1.15546943
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.15155984
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12253722
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.11455385
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11229285
80VDR_23849224_ChIP-Seq_CD4+_Human1.08919187
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06719621
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06516551
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.06437481
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06077375
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05617245
86ETV1_20927104_ChIP-Seq_GIST48_Human1.05612182
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04068124
88FOXH1_21741376_ChIP-Seq_EPCs_Human1.02862611
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01974387
90RUNX2_22187159_ChIP-Seq_PCA_Human1.01585670
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00431778
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98880234
93AR_25329375_ChIP-Seq_VCAP_Human0.98678819
94NCOR_22424771_ChIP-Seq_293T_Human0.98482156
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98248389
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.98229114
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97214546
98RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95745215
99NFYB_21822215_ChIP-Seq_K562_Human0.95075723
100TBL1_22424771_ChIP-Seq_293T_Human0.94507342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.76462617
2MP0005075_abnormal_melanosome_morpholog3.13221736
3MP0003195_calcinosis3.10344149
4MP0006292_abnormal_olfactory_placode3.05082768
5MP0005408_hypopigmentation3.00483514
6MP0005174_abnormal_tail_pigmentation2.67571760
7MP0008877_abnormal_DNA_methylation2.53645639
8MP0003221_abnormal_cardiomyocyte_apopto2.42423419
9MP0002138_abnormal_hepatobiliary_system2.37689064
10MP0008872_abnormal_physiological_respon2.35816314
11MP0005551_abnormal_eye_electrophysiolog2.25145828
12MP0001486_abnormal_startle_reflex2.18064953
13MP0002735_abnormal_chemical_nociception2.17336126
14MP0000372_irregular_coat_pigmentation2.17046338
15MP0000569_abnormal_digit_pigmentation2.14730280
16MP0004145_abnormal_muscle_electrophysio2.14616368
17MP0002876_abnormal_thyroid_physiology2.12440393
18MP0006035_abnormal_mitochondrial_morpho2.01071770
19MP0003011_delayed_dark_adaptation1.77396559
20MP0004270_analgesia1.76217454
21MP0009384_cardiac_valve_regurgitation1.70703026
22MP0001293_anophthalmia1.66218827
23MP0003890_abnormal_embryonic-extraembry1.57859061
24MP0001968_abnormal_touch/_nociception1.53243013
25MP0006072_abnormal_retinal_apoptosis1.46109248
26MP0006054_spinal_hemorrhage1.37985298
27MP0002127_abnormal_cardiovascular_syste1.35972405
28MP0001440_abnormal_grooming_behavior1.35469613
29MP0002277_abnormal_respiratory_mucosa1.35340141
30MP0004484_altered_response_of1.32690310
31MP0005084_abnormal_gallbladder_morpholo1.31085918
32MP0010368_abnormal_lymphatic_system1.30919925
33MP0008789_abnormal_olfactory_epithelium1.28457574
34MP0002653_abnormal_ependyma_morphology1.25990413
35MP0000749_muscle_degeneration1.24888677
36MP0002837_dystrophic_cardiac_calcinosis1.24720814
37MP0002736_abnormal_nociception_after1.23854998
38MP0003718_maternal_effect1.23501209
39MP0002095_abnormal_skin_pigmentation1.20844226
40MP0002272_abnormal_nervous_system1.19363290
41MP0004215_abnormal_myocardial_fiber1.18435033
42MP0003183_abnormal_peptide_metabolism1.17771361
43MP0004885_abnormal_endolymph1.14849570
44MP0005253_abnormal_eye_physiology1.14231259
45MP0010094_abnormal_chromosome_stability1.14208821
46MP0002733_abnormal_thermal_nociception1.12067677
47MP0002249_abnormal_larynx_morphology1.10429708
48MP0004924_abnormal_behavior1.06202040
49MP0005386_behavior/neurological_phenoty1.06202040
50MP0009046_muscle_twitch1.05508258
51MP0001501_abnormal_sleep_pattern1.05202332
52MP0003633_abnormal_nervous_system1.04787706
53MP0003879_abnormal_hair_cell1.03774680
54MP0008058_abnormal_DNA_repair1.03619109
55MP0003635_abnormal_synaptic_transmissio1.03339615
56MP0005195_abnormal_posterior_eye1.03149109
57MP0001485_abnormal_pinna_reflex1.02731184
58MP0001984_abnormal_olfaction1.01412067
59MP0002102_abnormal_ear_morphology1.00426004
60MP0004381_abnormal_hair_follicle0.99492717
61MP0002938_white_spotting0.98379462
62MP0000613_abnormal_salivary_gland0.97600069
63MP0009745_abnormal_behavioral_response0.97241742
64MP0000371_diluted_coat_color0.96981607
65MP0002734_abnormal_mechanical_nocicepti0.95932658
66MP0005395_other_phenotype0.94204816
67MP0002168_other_aberrant_phenotype0.93205348
68MP0003698_abnormal_male_reproductive0.91460247
69MP0003119_abnormal_digestive_system0.89630588
70MP0003045_fibrosis0.88146856
71MP0000778_abnormal_nervous_system0.87587671
72MP0002088_abnormal_embryonic_growth/wei0.86976375
73MP0002160_abnormal_reproductive_system0.85408367
74MP0002332_abnormal_exercise_endurance0.84948194
75MP0005389_reproductive_system_phenotype0.84336895
76MP0000465_gastrointestinal_hemorrhage0.84265299
77MP0004133_heterotaxia0.84097850
78MP0003136_yellow_coat_color0.82130610
79MP0002006_tumorigenesis0.81474185
80MP0001970_abnormal_pain_threshold0.80592666
81MP0003984_embryonic_growth_retardation0.79944205
82MP0002254_reproductive_system_inflammat0.79657831
83MP0005165_increased_susceptibility_to0.79035362
84MP0005085_abnormal_gallbladder_physiolo0.76375889
85MP0004142_abnormal_muscle_tone0.75295322
86MP0004084_abnormal_cardiac_muscle0.74943079
87MP0002233_abnormal_nose_morphology0.74817203
88MP0001929_abnormal_gametogenesis0.74620917
89MP0000762_abnormal_tongue_morphology0.73845672
90MP0003631_nervous_system_phenotype0.71985552
91MP0005646_abnormal_pituitary_gland0.71926643
92MP0005620_abnormal_muscle_contractility0.71856314
93MP0002166_altered_tumor_susceptibility0.71517527
94MP0001188_hyperpigmentation0.71067705
95MP0005410_abnormal_fertilization0.71003285
96MP0002067_abnormal_sensory_capabilities0.70727081
97MP0003111_abnormal_nucleus_morphology0.70007788
98MP0003137_abnormal_impulse_conducting0.69861160
99MP0001672_abnormal_embryogenesis/_devel0.69531867
100MP0005380_embryogenesis_phenotype0.69531867

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)5.02431278
2B lymphocytopenia (HP:0010976)4.97346927
3Conical tooth (HP:0000698)4.67648697
4Colon cancer (HP:0003003)4.43424640
5Increased serum pyruvate (HP:0003542)3.55062591
6Hematochezia (HP:0002573)3.46534263
7Joint hemorrhage (HP:0005261)3.29465484
8Broad-based gait (HP:0002136)3.19708507
9Prolonged partial thromboplastin time (HP:0003645)3.16324998
10Rhabdomyosarcoma (HP:0002859)2.91185161
11Inability to walk (HP:0002540)2.88642387
12IgG deficiency (HP:0004315)2.86930508
13Thyroiditis (HP:0100646)2.78381665
14Biliary tract neoplasm (HP:0100574)2.76592556
15Abnormality of the intrinsic pathway (HP:0010989)2.75262132
16Ependymoma (HP:0002888)2.73810857
17Abnormality of alanine metabolism (HP:0010916)2.70944964
18Hyperalaninemia (HP:0003348)2.70944964
19Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70944964
20IgM deficiency (HP:0002850)2.70317708
21Molar tooth sign on MRI (HP:0002419)2.66217924
22Abnormality of midbrain morphology (HP:0002418)2.66217924
23Abnormality of glycolysis (HP:0004366)2.66057483
24Pancreatic cysts (HP:0001737)2.55373627
25Severe combined immunodeficiency (HP:0004430)2.52088026
26Hepatocellular necrosis (HP:0001404)2.50189916
27Glioma (HP:0009733)2.49952347
28Neoplasm of the small intestine (HP:0100833)2.47702316
29Hyperglycinuria (HP:0003108)2.40962653
30Chronic sinusitis (HP:0011109)2.39475416
31Hyperventilation (HP:0002883)2.37565468
32Abnormality of the astrocytes (HP:0100707)2.35250930
33Astrocytoma (HP:0009592)2.35250930
34Abnormal rod and cone electroretinograms (HP:0008323)2.34142821
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32365376
36Pancreatic fibrosis (HP:0100732)2.25577004
37Mitochondrial inheritance (HP:0001427)2.25355087
38Long nose (HP:0003189)2.21466421
39Poor eye contact (HP:0000817)2.17961063
40Pendular nystagmus (HP:0012043)2.17567726
41Adactyly (HP:0009776)2.17143864
42Combined immunodeficiency (HP:0005387)2.15113495
43Meckel diverticulum (HP:0002245)2.14924142
44Neoplasm of the rectum (HP:0100743)2.13690434
45Hypoplastic pelvis (HP:0008839)2.10202740
46Hepatic necrosis (HP:0002605)2.09126384
47Neoplasm of striated muscle (HP:0009728)2.06357358
48Neoplasm of the colon (HP:0100273)2.05107926
49Type II lissencephaly (HP:0007260)2.03097745
50Abnormality of the ileum (HP:0001549)2.02515828
51Increased CSF lactate (HP:0002490)2.01070180
52Small hand (HP:0200055)1.99991719
53Abnormality of macular pigmentation (HP:0008002)1.99688227
54True hermaphroditism (HP:0010459)1.97894526
55Congenital stationary night blindness (HP:0007642)1.95823089
56Abnormality of chromosome stability (HP:0003220)1.95523219
57Spinal muscular atrophy (HP:0007269)1.94477471
58Abnormality of serum amino acid levels (HP:0003112)1.94374689
59Acute necrotizing encephalopathy (HP:0006965)1.94242277
60Abnormal mitochondria in muscle tissue (HP:0008316)1.93536254
61Aplasia/Hypoplasia of the uvula (HP:0010293)1.92251602
62Abnormal ciliary motility (HP:0012262)1.92058377
63Febrile seizures (HP:0002373)1.89033109
64Clubbing of toes (HP:0100760)1.88981708
65Abnormality of the labia minora (HP:0012880)1.88896910
66Protruding tongue (HP:0010808)1.88788380
67Abnormality of the pons (HP:0007361)1.88703555
68Stomach cancer (HP:0012126)1.88665563
69Abnormal respiratory epithelium morphology (HP:0012253)1.87466023
70Abnormal respiratory motile cilium morphology (HP:0005938)1.87466023
71Birth length less than 3rd percentile (HP:0003561)1.85477222
72Progressive inability to walk (HP:0002505)1.85216956
73Dynein arm defect of respiratory motile cilia (HP:0012255)1.84257117
74Absent/shortened dynein arms (HP:0200106)1.84257117
75Acute encephalopathy (HP:0006846)1.83758610
76Prominent metopic ridge (HP:0005487)1.82254754
77Hypoplasia of the pons (HP:0012110)1.82115197
78Abnormal albumin level (HP:0012116)1.82113730
79Hypoalbuminemia (HP:0003073)1.82113730
80Action tremor (HP:0002345)1.81948671
81Drooling (HP:0002307)1.80950486
82IgA deficiency (HP:0002720)1.80258697
83Short chin (HP:0000331)1.79319987
84Recurrent bronchitis (HP:0002837)1.78892373
85Abnormality of the costochondral junction (HP:0000919)1.78139672
86Absent speech (HP:0001344)1.76487911
87Absent eyebrow (HP:0002223)1.76380184
88Erythroderma (HP:0001019)1.75670223
89Submucous cleft hard palate (HP:0000176)1.74954732
90Nephronophthisis (HP:0000090)1.73629834
91Chronic otitis media (HP:0000389)1.71730644
92Agnosia (HP:0010524)1.69592055
93Eosinophilia (HP:0001880)1.69148377
94Progressive macrocephaly (HP:0004481)1.68539673
95Abnormality of the pubic bones (HP:0003172)1.67923832
96Hypoplastic iliac wings (HP:0002866)1.66794265
97Preaxial foot polydactyly (HP:0001841)1.66216519
98Posterior subcapsular cataract (HP:0007787)1.64163257
99Constricted visual fields (HP:0001133)1.64157878
100Abnormality of the preputium (HP:0100587)1.62835371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.89137418
2EIF2AK33.73170747
3MAP3K63.67632969
4EIF2AK13.55883179
5CCNB13.34392410
6NLK3.03569032
7FRK3.02500747
8MAP3K42.97604634
9MAP2K72.76973527
10TRIM282.49899526
11PDK22.03692125
12ZAK2.00439651
13TSSK61.89595327
14MAP2K41.77646816
15TIE11.70836956
16TXK1.68946724
17SGK21.57679093
18NUAK11.52709003
19STK391.52217060
20CASK1.49625591
21TAF11.48091689
22WNK41.37573015
23EIF2AK21.37205452
24AKT31.35647111
25MST41.35368392
26CSNK1G11.33877381
27SIK31.33389464
28VRK11.30980723
29PLK31.30679056
30PLK21.27345972
31PHKG21.24395475
32PHKG11.24395475
33GRK11.17054529
34ADRBK21.14561755
35TEC1.14376421
36INSRR1.12921107
37WNK31.05842387
38TYK21.05144919
39TLK10.99481576
40MAP4K20.97696120
41MAP3K50.96483568
42SGK4940.96106549
43SGK2230.96106549
44SGK30.92695426
45MINK10.90015950
46PAK30.84966898
47KIT0.82349607
48IKBKE0.80738960
49STK38L0.80307259
50MAP2K60.75172788
51STK240.74763710
52MKNK20.72880920
53NEK10.70671827
54BCR0.69300328
55OXSR10.67226665
56IKBKB0.67090394
57YES10.64628056
58MAPK130.63078052
59KSR10.59859053
60CDK40.59095546
61OBSCN0.58235228
62TNIK0.58034999
63MAP2K20.55757614
64PRKCG0.54102194
65VRK20.52706548
66PLK40.51523386
67TAOK30.50759113
68MAP3K140.50469635
69DYRK20.49707234
70FES0.49478979
71PBK0.48599070
72PRKCE0.47753385
73STK40.47299899
74PIK3CA0.46116570
75ADRBK10.44019769
76FGFR30.43048712
77BMPR1B0.41178056
78NTRK30.40916659
79STK30.40338063
80PRKG10.39425279
81PRKCQ0.36914868
82PRKCD0.32696870
83CSNK1A10.31584385
84NEK90.30681786
85SIK20.30330864
86SGK10.29793347
87ATR0.29273245
88NEK20.29019706
89ATM0.28722749
90MAPK120.28687192
91TRPM70.28666406
92CSK0.27968870
93NEK60.27383919
94FGFR20.25891098
95PRKCI0.25073581
96MKNK10.24710917
97LCK0.24303010
98MARK10.23719554
99ROCK10.23102098
100INSR0.22628069

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.79836998
2Proteasome_Homo sapiens_hsa030503.61910301
3Steroid biosynthesis_Homo sapiens_hsa001003.27517191
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.10694921
5Mismatch repair_Homo sapiens_hsa034302.88402328
6Non-homologous end-joining_Homo sapiens_hsa034502.17908836
7Butanoate metabolism_Homo sapiens_hsa006502.17461449
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15835043
9Primary immunodeficiency_Homo sapiens_hsa053402.13940367
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09191188
11Linoleic acid metabolism_Homo sapiens_hsa005912.02236547
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96864366
13Oxidative phosphorylation_Homo sapiens_hsa001901.95029837
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91850561
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83191277
16Homologous recombination_Homo sapiens_hsa034401.78734662
17Parkinsons disease_Homo sapiens_hsa050121.68605314
18Tryptophan metabolism_Homo sapiens_hsa003801.60520268
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58561958
20Basal transcription factors_Homo sapiens_hsa030221.54218498
21Nicotine addiction_Homo sapiens_hsa050331.51990192
22Taste transduction_Homo sapiens_hsa047421.46348530
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40875975
24Phototransduction_Homo sapiens_hsa047441.40451091
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37102627
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37047344
27One carbon pool by folate_Homo sapiens_hsa006701.34395871
28Fatty acid elongation_Homo sapiens_hsa000621.34143716
29Ether lipid metabolism_Homo sapiens_hsa005651.31904518
30Huntingtons disease_Homo sapiens_hsa050161.29913816
31RNA polymerase_Homo sapiens_hsa030201.24626579
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23350932
33Fatty acid degradation_Homo sapiens_hsa000711.22328084
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.18495938
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15037770
36Nitrogen metabolism_Homo sapiens_hsa009101.14968511
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14703064
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09313433
39Arachidonic acid metabolism_Homo sapiens_hsa005901.08005756
40Propanoate metabolism_Homo sapiens_hsa006401.06990585
41Alzheimers disease_Homo sapiens_hsa050101.02004196
42Cardiac muscle contraction_Homo sapiens_hsa042600.99926055
43Fanconi anemia pathway_Homo sapiens_hsa034600.95729060
44Glutamatergic synapse_Homo sapiens_hsa047240.90342010
45Fat digestion and absorption_Homo sapiens_hsa049750.88606056
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86160478
47RNA degradation_Homo sapiens_hsa030180.84885629
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83682090
49GABAergic synapse_Homo sapiens_hsa047270.82265531
50DNA replication_Homo sapiens_hsa030300.80493489
51Caffeine metabolism_Homo sapiens_hsa002320.80480259
52Nucleotide excision repair_Homo sapiens_hsa034200.79089827
53Long-term depression_Homo sapiens_hsa047300.76523393
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75108895
55Fatty acid metabolism_Homo sapiens_hsa012120.68798182
56Pyruvate metabolism_Homo sapiens_hsa006200.67760360
57beta-Alanine metabolism_Homo sapiens_hsa004100.67319422
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65744887
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63832921
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60695886
61Collecting duct acid secretion_Homo sapiens_hsa049660.60378581
62Serotonergic synapse_Homo sapiens_hsa047260.59701831
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.59638930
64Ovarian steroidogenesis_Homo sapiens_hsa049130.56193182
65RNA transport_Homo sapiens_hsa030130.55929985
66Ribosome_Homo sapiens_hsa030100.55737795
67Morphine addiction_Homo sapiens_hsa050320.55128516
68Olfactory transduction_Homo sapiens_hsa047400.53485380
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52321444
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.52308414
71Circadian entrainment_Homo sapiens_hsa047130.50355403
72Salivary secretion_Homo sapiens_hsa049700.49484169
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49098044
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48952663
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47151523
76T cell receptor signaling pathway_Homo sapiens_hsa046600.46594725
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46294422
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45517717
79Protein export_Homo sapiens_hsa030600.44086805
80Sphingolipid metabolism_Homo sapiens_hsa006000.41421455
81Oocyte meiosis_Homo sapiens_hsa041140.41285180
82Purine metabolism_Homo sapiens_hsa002300.40669041
83Oxytocin signaling pathway_Homo sapiens_hsa049210.40635316
84Retinol metabolism_Homo sapiens_hsa008300.39520055
85Lysine degradation_Homo sapiens_hsa003100.38536479
86Glycerolipid metabolism_Homo sapiens_hsa005610.37770601
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37459177
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36894280
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36731629
90cAMP signaling pathway_Homo sapiens_hsa040240.36666907
91Circadian rhythm_Homo sapiens_hsa047100.36536330
92Histidine metabolism_Homo sapiens_hsa003400.35692617
93Metabolic pathways_Homo sapiens_hsa011000.35634515
94Pancreatic secretion_Homo sapiens_hsa049720.33243106
95Chemical carcinogenesis_Homo sapiens_hsa052040.33084149
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31339520
97Pyrimidine metabolism_Homo sapiens_hsa002400.30330055
98Gastric acid secretion_Homo sapiens_hsa049710.30303045
99Peroxisome_Homo sapiens_hsa041460.27756621
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23353288

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