PTPN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.94322648
2locomotory exploration behavior (GO:0035641)5.86424789
3synaptic vesicle maturation (GO:0016188)5.26454221
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15119076
5vocalization behavior (GO:0071625)4.93469116
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.88225171
7regulation of synaptic vesicle exocytosis (GO:2000300)4.78097520
8glutamate secretion (GO:0014047)4.76828648
9synaptic vesicle exocytosis (GO:0016079)4.68651075
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45573951
11activated T cell proliferation (GO:0050798)4.45144096
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.44050396
13cellular potassium ion homeostasis (GO:0030007)4.39637599
14neurotransmitter secretion (GO:0007269)4.35375668
15regulation of glutamate receptor signaling pathway (GO:1900449)4.33285850
16gamma-aminobutyric acid transport (GO:0015812)4.24395906
17phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.19755055
18cerebellar Purkinje cell differentiation (GO:0021702)4.19259080
19neural tube formation (GO:0001841)4.17949319
20layer formation in cerebral cortex (GO:0021819)4.16882662
21proline transport (GO:0015824)4.13709441
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.11568842
23neuronal action potential propagation (GO:0019227)4.11394757
24regulation of synaptic vesicle transport (GO:1902803)4.09489640
25sodium ion export (GO:0071436)4.05724898
26exploration behavior (GO:0035640)4.05541544
27presynaptic membrane assembly (GO:0097105)3.97650160
28neuron cell-cell adhesion (GO:0007158)3.90391430
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.89117465
30negative regulation of translation, ncRNA-mediated (GO:0040033)3.89117465
31regulation of translation, ncRNA-mediated (GO:0045974)3.89117465
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87550890
33synaptic transmission, glutamatergic (GO:0035249)3.85409722
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82383598
35neurotransmitter-gated ion channel clustering (GO:0072578)3.80055672
36protein localization to synapse (GO:0035418)3.78143618
37glutamate receptor signaling pathway (GO:0007215)3.74464204
38neuron-neuron synaptic transmission (GO:0007270)3.73692918
39activation of protein kinase A activity (GO:0034199)3.72627815
40cerebellar granule cell differentiation (GO:0021707)3.72202963
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71698683
42long-term memory (GO:0007616)3.70269907
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69497013
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69364308
45presynaptic membrane organization (GO:0097090)3.60628253
46regulation of neuronal synaptic plasticity (GO:0048168)3.56944291
47positive regulation of synapse maturation (GO:0090129)3.56256606
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.49157291
49regulation of synapse structural plasticity (GO:0051823)3.48917233
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48712197
51negative regulation of cell killing (GO:0031342)3.48712197
52cellular response to interleukin-15 (GO:0071350)3.42903891
53protein K11-linked deubiquitination (GO:0035871)3.41742007
54cell communication by electrical coupling (GO:0010644)3.41148096
55dendritic spine morphogenesis (GO:0060997)3.40441597
56neurotransmitter transport (GO:0006836)3.39393009
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38326982
58negative regulation of cAMP-mediated signaling (GO:0043951)3.36142146
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31238679
60long-term synaptic potentiation (GO:0060291)3.29765277
61establishment of nucleus localization (GO:0040023)3.29087682
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.28176115
63regulation of postsynaptic membrane potential (GO:0060078)3.27653554
64positive regulation of membrane potential (GO:0045838)3.27113569
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26785264
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25526761
67prepulse inhibition (GO:0060134)3.24538975
68potassium ion import (GO:0010107)3.19657353
69histone mRNA catabolic process (GO:0071044)3.18742172
70regulation of meiosis I (GO:0060631)3.17942533
71vesicle transport along microtubule (GO:0047496)3.16615335
72regulation of ARF protein signal transduction (GO:0032012)3.15076270
73neuromuscular process controlling balance (GO:0050885)3.12873882
74postsynaptic membrane organization (GO:0001941)3.12610991
75regulation of neurotransmitter levels (GO:0001505)3.12516089
76dendrite morphogenesis (GO:0048813)3.12129503
77membrane depolarization during action potential (GO:0086010)3.09797990
78synaptic vesicle endocytosis (GO:0048488)3.09086028
79response to interleukin-15 (GO:0070672)3.08964139
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.08950019
81startle response (GO:0001964)3.07597974
82regulation of B cell receptor signaling pathway (GO:0050855)3.07029127
83cell differentiation in hindbrain (GO:0021533)3.07015971
84auditory behavior (GO:0031223)3.05684372
85retinal cone cell development (GO:0046549)3.03602427
86regulation of synaptic plasticity (GO:0048167)3.03150882
87regulation of dendritic spine morphogenesis (GO:0061001)3.02258390
88regulation of neurotransmitter secretion (GO:0046928)3.01104208
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00160838
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99235920
91response to auditory stimulus (GO:0010996)2.98918962
92glycine transport (GO:0015816)2.97800502
93membrane hyperpolarization (GO:0060081)2.96769343
94transmission of nerve impulse (GO:0019226)2.96727020
95innervation (GO:0060384)2.95982745
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94657091
97alanine transport (GO:0032328)2.93909377
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91638990
99cAMP catabolic process (GO:0006198)2.91619006
100atrial cardiac muscle cell action potential (GO:0086014)2.90406344
101regulation of clathrin-mediated endocytosis (GO:2000369)2.89874578
102synapse assembly (GO:0007416)2.89480887
103response to histamine (GO:0034776)2.88861694
104positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88075803
105neuron recognition (GO:0008038)2.87857812
106righting reflex (GO:0060013)2.87309215
107membrane depolarization (GO:0051899)2.87228358
108protein targeting to Golgi (GO:0000042)2.85920222
109potassium ion homeostasis (GO:0055075)2.85890418
110cyclic nucleotide catabolic process (GO:0009214)2.84304907
111L-amino acid import (GO:0043092)2.83900060
112axonal fasciculation (GO:0007413)2.83537688
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83523803
114social behavior (GO:0035176)2.82572900
115intraspecies interaction between organisms (GO:0051703)2.82572900
116negative T cell selection (GO:0043383)2.80727109
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79577608
118positive regulation of gamma-delta T cell activation (GO:0046645)2.78610682
119cellular sodium ion homeostasis (GO:0006883)2.78426597
120long term synaptic depression (GO:0060292)2.77997849
121regulation of voltage-gated calcium channel activity (GO:1901385)2.74635306
122regulation of gamma-delta T cell differentiation (GO:0045586)2.74590527
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73929658
124regulation of neurotransmitter transport (GO:0051588)2.72662363
125synapse organization (GO:0050808)2.72623558
126establishment of protein localization to Golgi (GO:0072600)2.71583244
127positive regulation of potassium ion transmembrane transport (GO:1901381)2.71043346
128organelle transport along microtubule (GO:0072384)2.70844910
129detection of calcium ion (GO:0005513)2.70183233
130response to pheromone (GO:0019236)2.69495905
131regulation of vesicle fusion (GO:0031338)2.69237039
132behavioral response to nicotine (GO:0035095)2.66534876
133inositol phosphate catabolic process (GO:0071545)2.66518283
134C4-dicarboxylate transport (GO:0015740)2.62447261
135positive T cell selection (GO:0043368)2.57438383
136negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.56703245
137nucleus localization (GO:0051647)2.52934405
138monoubiquitinated protein deubiquitination (GO:0035520)2.52023168
139microtubule anchoring (GO:0034453)2.51707421
140reflex (GO:0060004)2.50483727
141positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49581552
142regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49581552
143protein K48-linked deubiquitination (GO:0071108)2.49074747
144regulation of protein glycosylation (GO:0060049)2.47949931
145negative thymic T cell selection (GO:0045060)2.46231200
146positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45458336
147regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45458336
148DNA deamination (GO:0045006)2.45148922
149auditory receptor cell stereocilium organization (GO:0060088)2.44131251
150positive regulation of dendritic spine morphogenesis (GO:0061003)2.44003546
151negative regulation of neurotransmitter transport (GO:0051589)2.43484409
152cytoplasmic mRNA processing body assembly (GO:0033962)2.41900671
153regulation of cell communication by electrical coupling (GO:0010649)2.39689529
154protein prenylation (GO:0018342)2.38897252
155prenylation (GO:0097354)2.38897252
156microtubule nucleation (GO:0007020)2.37794833
157positive regulation of granulocyte differentiation (GO:0030854)2.36856718
158adult walking behavior (GO:0007628)2.36560693
159axoneme assembly (GO:0035082)2.35177651
160protein K63-linked deubiquitination (GO:0070536)2.34804885
161interferon-gamma production (GO:0032609)2.32411361
162mechanosensory behavior (GO:0007638)2.31046773
163pyrimidine nucleobase catabolic process (GO:0006208)2.29920261
164regulation of collateral sprouting (GO:0048670)2.29347912
165positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28173838
166protein localization to Golgi apparatus (GO:0034067)2.27750536
167photoreceptor cell maintenance (GO:0045494)2.25797740
168antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25733096
169neuronal action potential (GO:0019228)2.25651238
170limb bud formation (GO:0060174)2.25599764
171positive regulation of mRNA catabolic process (GO:0061014)2.25538421
172negative regulation of DNA-dependent DNA replication (GO:2000104)2.24512592
173pre-miRNA processing (GO:0031054)2.23912079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13918760
2GBX2_23144817_ChIP-Seq_PC3_Human3.36970408
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56532207
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53157558
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51238883
6DROSHA_22980978_ChIP-Seq_HELA_Human2.44582482
7REST_21632747_ChIP-Seq_MESCs_Mouse2.41158176
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33677563
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.32480740
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.31600477
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27439301
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15468183
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13115679
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13115679
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09923371
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05422715
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02806789
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02043349
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00655167
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.97907081
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97418247
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94289080
23EWS_26573619_Chip-Seq_HEK293_Human1.91566117
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88364416
25SMAD4_21799915_ChIP-Seq_A2780_Human1.88232154
26VDR_22108803_ChIP-Seq_LS180_Human1.88228471
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87010855
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.84764455
29AR_21572438_ChIP-Seq_LNCaP_Human1.84293274
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.82925385
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77723195
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.76607487
33* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75298427
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73499747
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68219801
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.67208764
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66916623
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63226281
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.62012347
40* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60238922
41* EZH2_27294783_Chip-Seq_NPCs_Mouse1.58173461
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57007891
43TAF15_26573619_Chip-Seq_HEK293_Human1.57007457
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56850906
45STAT3_23295773_ChIP-Seq_U87_Human1.54320576
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.53634655
47ZNF274_21170338_ChIP-Seq_K562_Hela1.51999584
48* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51715716
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47555631
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47362925
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44884137
52* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43791746
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43439084
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.43425722
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43242849
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.42291363
57* NFE2_27457419_Chip-Seq_LIVER_Mouse1.41888016
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41355542
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40545635
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39957015
61* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39856272
62* AR_19668381_ChIP-Seq_PC3_Human1.39760284
63P300_19829295_ChIP-Seq_ESCs_Human1.38446212
64AR_25329375_ChIP-Seq_VCAP_Human1.37936822
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35974760
66TP53_16413492_ChIP-PET_HCT116_Human1.35456840
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.35280809
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.34718657
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32207988
70CBP_20019798_ChIP-Seq_JUKART_Human1.32207988
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.32145299
72RUNX_20019798_ChIP-Seq_JUKART_Human1.31801488
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31786856
74* TCF4_23295773_ChIP-Seq_U87_Human1.31756340
75AHR_22903824_ChIP-Seq_MCF-7_Human1.31630138
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31515145
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31023472
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29874257
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28381956
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27301804
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27262370
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26166828
83* P53_22387025_ChIP-Seq_ESCs_Mouse1.25441836
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25246218
85* CRX_20693478_ChIP-Seq_RETINA_Mouse1.22165740
86* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21623934
87* E2F1_18555785_Chip-Seq_ESCs_Mouse1.20897759
88* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20765544
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20468316
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20164668
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19621698
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19346495
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19052142
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18211357
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18203676
96TCF4_22108803_ChIP-Seq_LS180_Human1.17722500
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17041881
98IGF1R_20145208_ChIP-Seq_DFB_Human1.16869690
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16157989
100BCAT_22108803_ChIP-Seq_LS180_Human1.15052377
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.14797497
102* CMYC_18555785_Chip-Seq_ESCs_Mouse1.14668126
103KDM2B_26808549_Chip-Seq_REH_Human1.13337302
104* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13052242
105RNF2_27304074_Chip-Seq_NSC_Mouse1.12959457
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12912146
107* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12254236
108FUS_26573619_Chip-Seq_HEK293_Human1.09640536
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09263746
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09066906
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09031125
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08629247
113* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08148709
114RXR_22108803_ChIP-Seq_LS180_Human1.07692480
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.07572591
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07283298
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07283298
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07093047
119* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06914799
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06131213
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05918635
122* P300_18555785_Chip-Seq_ESCs_Mouse1.05343095
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.04843503
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.04527849
125* STAT3_18555785_Chip-Seq_ESCs_Mouse1.03604067
126ER_23166858_ChIP-Seq_MCF-7_Human1.03345002
127* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02985315
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02739846
129* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02431001
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02256978
131SOX2_19829295_ChIP-Seq_ESCs_Human1.02104110
132NANOG_19829295_ChIP-Seq_ESCs_Human1.02104110
133RUNX2_22187159_ChIP-Seq_PCA_Human1.01800676
134* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01307465
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01291576
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.98855573
137* OCT4_18555785_Chip-Seq_ESCs_Mouse0.97959922
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.97367357
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.96708842
140* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96568040
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.96140847
142KDM2B_26808549_Chip-Seq_K562_Human0.95975536
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95257103
144RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94824984
145* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94573084
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94333874
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.93427768
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.92969315
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92620842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.94753763
2* MP0003635_abnormal_synaptic_transmissio3.92863800
3MP0003880_abnormal_central_pattern3.73166767
4MP0009046_muscle_twitch3.66741587
5MP0008057_abnormal_DNA_replication3.21717094
6MP0009745_abnormal_behavioral_response3.16920265
7MP0004270_analgesia3.08942179
8* MP0002063_abnormal_learning/memory/cond3.00117214
9MP0002064_seizures2.97819141
10MP0005423_abnormal_somatic_nervous2.74341926
11MP0009780_abnormal_chondrocyte_physiolo2.69217441
12MP0002572_abnormal_emotion/affect_behav2.50921660
13MP0002272_abnormal_nervous_system2.42847074
14MP0008569_lethality_at_weaning2.42215986
15MP0001486_abnormal_startle_reflex2.41822218
16MP0002734_abnormal_mechanical_nocicepti2.25850475
17MP0002909_abnormal_adrenal_gland2.25219134
18MP0001968_abnormal_touch/_nociception2.21795239
19MP0003787_abnormal_imprinting2.18047489
20MP0001501_abnormal_sleep_pattern2.16341918
21MP0000569_abnormal_digit_pigmentation2.11343519
22MP0002067_abnormal_sensory_capabilities2.04401801
23MP0001440_abnormal_grooming_behavior1.89490972
24MP0005386_behavior/neurological_phenoty1.87497040
25MP0004924_abnormal_behavior1.87497040
26MP0002102_abnormal_ear_morphology1.83818361
27MP0005646_abnormal_pituitary_gland1.81506805
28MP0002822_catalepsy1.81021382
29MP0000013_abnormal_adipose_tissue1.79147508
30MP0001984_abnormal_olfaction1.73294522
31MP0002009_preneoplasia1.72920158
32MP0002557_abnormal_social/conspecific_i1.68590380
33MP0004885_abnormal_endolymph1.68381500
34MP0005075_abnormal_melanosome_morpholog1.68113552
35MP0002184_abnormal_innervation1.67420219
36MP0004811_abnormal_neuron_physiology1.63562810
37MP0000778_abnormal_nervous_system1.59266068
38MP0003763_abnormal_thymus_physiology1.55271613
39MP0005551_abnormal_eye_electrophysiolog1.52718592
40MP0003633_abnormal_nervous_system1.52035211
41MP0002733_abnormal_thermal_nociception1.49739200
42MP0003329_amyloid_beta_deposits1.49279585
43MP0001970_abnormal_pain_threshold1.45218767
44MP0002736_abnormal_nociception_after1.42739254
45MP0000955_abnormal_spinal_cord1.41532405
46MP0003890_abnormal_embryonic-extraembry1.39405470
47MP0004130_abnormal_muscle_cell1.39260341
48MP0004145_abnormal_muscle_electrophysio1.37236178
49MP0004215_abnormal_myocardial_fiber1.36088821
50MP0002735_abnormal_chemical_nociception1.35673771
51MP0002882_abnormal_neuron_morphology1.33768177
52MP0004858_abnormal_nervous_system1.32645130
53* MP0002066_abnormal_motor_capabilities/c1.32015983
54MP0002837_dystrophic_cardiac_calcinosis1.31960936
55MP0010234_abnormal_vibrissa_follicle1.31620438
56MP0005174_abnormal_tail_pigmentation1.28166555
57MP0001502_abnormal_circadian_rhythm1.26713440
58MP0003631_nervous_system_phenotype1.24706564
59MP0005645_abnormal_hypothalamus_physiol1.20524027
60MP0004147_increased_porphyrin_level1.20136760
61MP0003045_fibrosis1.17685431
62MP0000427_abnormal_hair_cycle1.17159935
63MP0003879_abnormal_hair_cell1.16945348
64MP0002152_abnormal_brain_morphology1.16353762
65MP0005671_abnormal_response_to1.15577105
66MP0003690_abnormal_glial_cell1.13573610
67MP0001485_abnormal_pinna_reflex1.13357545
68MP0000015_abnormal_ear_pigmentation1.11488820
69MP0008961_abnormal_basal_metabolism1.09738196
70MP0004233_abnormal_muscle_weight1.07975392
71MP0001299_abnormal_eye_distance/1.05051885
72MP0006072_abnormal_retinal_apoptosis1.03170563
73MP0001177_atelectasis1.02660915
74MP0002229_neurodegeneration1.01648592
75MP0000751_myopathy1.00080274
76MP0003632_abnormal_nervous_system0.99577140
77MP0003122_maternal_imprinting0.97586005
78MP0003195_calcinosis0.95798128
79MP0005535_abnormal_body_temperature0.95240498
80MP0006292_abnormal_olfactory_placode0.94559157
81MP0000003_abnormal_adipose_tissue0.91510320
82MP0005187_abnormal_penis_morphology0.90965607
83MP0006035_abnormal_mitochondrial_morpho0.88917798
84MP0004085_abnormal_heartbeat0.88261401
85MP0001986_abnormal_taste_sensitivity0.88191956
86MP0004742_abnormal_vestibular_system0.87856687
87MP0005253_abnormal_eye_physiology0.86205309
88MP0005623_abnormal_meninges_morphology0.86122228
89MP0004142_abnormal_muscle_tone0.86046043
90MP0000703_abnormal_thymus_morphology0.85806743
91MP0001188_hyperpigmentation0.83765128
92MP0002069_abnormal_eating/drinking_beha0.83262861
93MP0003634_abnormal_glial_cell0.82320993
94MP0008872_abnormal_physiological_respon0.82210359
95MP0002163_abnormal_gland_morphology0.81868017
96MP0002090_abnormal_vision0.80455152
97MP0003283_abnormal_digestive_organ0.79804047
98MP0004043_abnormal_pH_regulation0.79650599
99MP0002638_abnormal_pupillary_reflex0.79542082
100MP0004484_altered_response_of0.78163669
101MP0000631_abnormal_neuroendocrine_gland0.77675084
102MP0003698_abnormal_male_reproductive0.77156858
103MP0003567_abnormal_fetal_cardiomyocyte0.75564499
104MP0005666_abnormal_adipose_tissue0.74717306
105MP0006276_abnormal_autonomic_nervous0.74575187
106MP0000372_irregular_coat_pigmentation0.74218132
107MP0002095_abnormal_skin_pigmentation0.72843027
108MP0003137_abnormal_impulse_conducting0.71682660
109MP0005670_abnormal_white_adipose0.71241638
110MP0003121_genomic_imprinting0.70420746
111MP0002877_abnormal_melanocyte_morpholog0.69726639
112MP0005375_adipose_tissue_phenotype0.69610233
113MP0003646_muscle_fatigue0.68330758
114MP0001929_abnormal_gametogenesis0.67829856
115MP0008877_abnormal_DNA_methylation0.66577866
116MP0008995_early_reproductive_senescence0.65921248
117MP0008874_decreased_physiological_sensi0.65623186
118MP0008058_abnormal_DNA_repair0.65450642
119MP0004036_abnormal_muscle_relaxation0.65385762
120MP0001963_abnormal_hearing_physiology0.65308075
121MP0001943_abnormal_respiration0.64763432
122MP0003724_increased_susceptibility_to0.63431686
123MP0005379_endocrine/exocrine_gland_phen0.63175440
124MP0002752_abnormal_somatic_nervous0.63127013
125MP0002166_altered_tumor_susceptibility0.63119183
126MP0004084_abnormal_cardiac_muscle0.61345822
127MP0005394_taste/olfaction_phenotype0.60853843
128MP0005499_abnormal_olfactory_system0.60853843
129MP0003123_paternal_imprinting0.60672926
130MP0010769_abnormal_survival0.60465833
131MP0004185_abnormal_adipocyte_glucose0.60218648
132MP0002751_abnormal_autonomic_nervous0.59514452

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.25213686
2Focal seizures (HP:0007359)4.71595958
3Progressive cerebellar ataxia (HP:0002073)4.52858835
4Visual hallucinations (HP:0002367)4.20894415
5Febrile seizures (HP:0002373)4.18650028
6Myokymia (HP:0002411)4.16368170
7Epileptic encephalopathy (HP:0200134)4.14886512
8Action tremor (HP:0002345)4.14426315
9Atonic seizures (HP:0010819)4.13944501
10Gaze-evoked nystagmus (HP:0000640)3.76729772
11Absence seizures (HP:0002121)3.70641463
12Dysmetric saccades (HP:0000641)3.63927902
13Broad-based gait (HP:0002136)3.56758870
14Truncal ataxia (HP:0002078)3.56421334
15Dysdiadochokinesis (HP:0002075)3.50438506
16T lymphocytopenia (HP:0005403)3.46239882
17Volvulus (HP:0002580)3.43503342
18Hepatoblastoma (HP:0002884)3.40722661
19Hyperventilation (HP:0002883)3.33441275
20Impaired vibration sensation in the lower limbs (HP:0002166)3.32928447
21Genetic anticipation (HP:0003743)3.27213350
22Impaired smooth pursuit (HP:0007772)3.22992093
23Abnormality of the labia minora (HP:0012880)3.17764507
24Hemiplegia (HP:0002301)3.14705723
25Poor eye contact (HP:0000817)3.14347511
26Dialeptic seizures (HP:0011146)3.14113261
27Abnormal social behavior (HP:0012433)3.09584905
28Impaired social interactions (HP:0000735)3.09584905
29Abnormality of T cell number (HP:0011839)3.06802954
30Urinary bladder sphincter dysfunction (HP:0002839)3.06372772
31Generalized tonic-clonic seizures (HP:0002069)3.05641755
32Abnormality of ocular smooth pursuit (HP:0000617)3.01908753
33Scanning speech (HP:0002168)3.00110704
34Abnormality of the lower motor neuron (HP:0002366)3.00048621
35Drooling (HP:0002307)2.99988195
36Excessive salivation (HP:0003781)2.99988195
37Depression (HP:0000716)2.97282330
38Macroorchidism (HP:0000053)2.83202680
39Postural instability (HP:0002172)2.81397700
40Intention tremor (HP:0002080)2.73956021
41Dysmetria (HP:0001310)2.73840960
42Thyroiditis (HP:0100646)2.70971466
43Papilledema (HP:0001085)2.66372384
44Urinary urgency (HP:0000012)2.63471090
45Abnormality of the renal cortex (HP:0011035)2.61802696
46Abnormality of binocular vision (HP:0011514)2.58314017
47Diplopia (HP:0000651)2.58314017
48Pancreatic cysts (HP:0001737)2.56392014
49Pancreatic fibrosis (HP:0100732)2.55168047
50Colon cancer (HP:0003003)2.50386886
51Hemiparesis (HP:0001269)2.49896237
52Abnormal eating behavior (HP:0100738)2.47290076
53Progressive inability to walk (HP:0002505)2.44635233
54Resting tremor (HP:0002322)2.40692180
55Megalencephaly (HP:0001355)2.39942958
56Long clavicles (HP:0000890)2.39547148
57Insidious onset (HP:0003587)2.33125752
58Termporal pattern (HP:0011008)2.33125752
59Ankle clonus (HP:0011448)2.31307678
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.29694771
61Intestinal atresia (HP:0011100)2.29379923
62Central scotoma (HP:0000603)2.25969533
63Oligodactyly (hands) (HP:0001180)2.24804274
64Anxiety (HP:0000739)2.24581479
65Impaired vibratory sensation (HP:0002495)2.24411054
66Abnormality of the renal medulla (HP:0100957)2.23292304
67Neoplasm of the adrenal cortex (HP:0100641)2.22096149
68Inappropriate behavior (HP:0000719)2.20501089
69Severe combined immunodeficiency (HP:0004430)2.19964703
70Aqueductal stenosis (HP:0002410)2.18483482
71Fair hair (HP:0002286)2.18053820
72Stomach cancer (HP:0012126)2.15549963
73Absent speech (HP:0001344)2.15364413
74Medial flaring of the eyebrow (HP:0010747)2.14749037
75Blue irides (HP:0000635)2.13839274
76Inability to walk (HP:0002540)2.13666975
77Status epilepticus (HP:0002133)2.13285514
78Epileptiform EEG discharges (HP:0011182)2.13047675
79Bradykinesia (HP:0002067)2.12616129
80True hermaphroditism (HP:0010459)2.12472616
81Supranuclear gaze palsy (HP:0000605)2.12283576
82Spastic gait (HP:0002064)2.12248639
83Pheochromocytoma (HP:0002666)2.12083087
84Nephronophthisis (HP:0000090)2.11293383
85EEG with generalized epileptiform discharges (HP:0011198)2.10048745
86Increased density of long bones (HP:0006392)2.09151832
87Gait ataxia (HP:0002066)2.09110761
88Abnormality of the corticospinal tract (HP:0002492)2.06773428
89Nephrogenic diabetes insipidus (HP:0009806)2.03467514
90Stereotypic behavior (HP:0000733)2.03279142
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98240391
92Hypochromic microcytic anemia (HP:0004840)1.98151644
93Amyotrophic lateral sclerosis (HP:0007354)1.97699604
94Hypsarrhythmia (HP:0002521)1.97462862
95Pointed chin (HP:0000307)1.97203172
96Molar tooth sign on MRI (HP:0002419)1.96955167
97Abnormality of midbrain morphology (HP:0002418)1.96955167
98Ventricular fibrillation (HP:0001663)1.95072708
99Congenital stationary night blindness (HP:0007642)1.93660868
100Genital tract atresia (HP:0001827)1.93589907
101Short chin (HP:0000331)1.93229641
102Agitation (HP:0000713)1.93042554
103Gait imbalance (HP:0002141)1.92804994
104Protruding tongue (HP:0010808)1.92140518
105Papillary thyroid carcinoma (HP:0002895)1.91840891
106Horizontal nystagmus (HP:0000666)1.90430859
107Abnormality of saccadic eye movements (HP:0000570)1.90383975
108Lower limb muscle weakness (HP:0007340)1.89862831
109Amblyopia (HP:0000646)1.89564443
110Abnormality of the astrocytes (HP:0100707)1.88669306
111Astrocytoma (HP:0009592)1.88669306
112Tetraplegia (HP:0002445)1.88437517
113Renal cortical cysts (HP:0000803)1.88096563
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.86976707
115Abnormality of salivation (HP:0100755)1.86569098
116Bundle branch block (HP:0011710)1.85366326
117Ankyloglossia (HP:0010296)1.83932727
118Hip dysplasia (HP:0001385)1.83157015
119Intellectual disability, profound (HP:0002187)1.82896062
120Hypoplastic labia majora (HP:0000059)1.82791581
121Poor coordination (HP:0002370)1.82360701
122Thyroid carcinoma (HP:0002890)1.80498271
123Dyskinesia (HP:0100660)1.80427340
124Abnormality of eosinophils (HP:0001879)1.79955836
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.79315767
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79315767
127Vaginal atresia (HP:0000148)1.78774207
128Congenital primary aphakia (HP:0007707)1.78128450
129Mutism (HP:0002300)1.78031934
130Obsessive-compulsive behavior (HP:0000722)1.77863495
131Calf muscle hypertrophy (HP:0008981)1.77634617
132Stomatitis (HP:0010280)1.77408327
133Abolished electroretinogram (ERG) (HP:0000550)1.77029555
134Congenital sensorineural hearing impairment (HP:0008527)1.75703541
135Neoplasm of the heart (HP:0100544)1.75598853
136Postural tremor (HP:0002174)1.75586480
137Abnormality of the labia majora (HP:0012881)1.75416780
138Lower limb asymmetry (HP:0100559)1.75186585
139Annular pancreas (HP:0001734)1.74123157
140Widely spaced teeth (HP:0000687)1.74052215
141Insomnia (HP:0100785)1.73605261
142Generalized hypopigmentation of hair (HP:0011358)1.72458574
143Chronic hepatic failure (HP:0100626)1.72347755
144Exercise-induced myalgia (HP:0003738)1.71657476
145Menstrual irregularities (HP:0000858)1.71229336
146Labial hypoplasia (HP:0000066)1.70577985
147Muscle hypertrophy of the lower extremities (HP:0008968)1.70095239
148Aplasia involving bones of the extremities (HP:0009825)1.68592713
149Aplasia involving bones of the upper limbs (HP:0009823)1.68592713
150Aplasia of the phalanges of the hand (HP:0009802)1.68592713
151Truncal obesity (HP:0001956)1.68405064
152Neuroendocrine neoplasm (HP:0100634)1.67267209
153Abnormal hair whorl (HP:0010721)1.67219034
154Neoplasm of the oral cavity (HP:0100649)1.66477144
155Attenuation of retinal blood vessels (HP:0007843)1.65874620
156Scotoma (HP:0000575)1.65579659
157Enlarged penis (HP:0000040)1.65316979
158Limb ataxia (HP:0002070)1.64710839
159Pancreatic islet-cell hyperplasia (HP:0004510)1.63585379
160Abnormality of T cells (HP:0002843)1.63510640
161Polydipsia (HP:0001959)1.62761549
162Abnormal drinking behavior (HP:0030082)1.62761549
163Neoplasm of the small intestine (HP:0100833)1.61619740
164Cupped ear (HP:0000378)1.60873827
165Hematochezia (HP:0002573)1.60767124
166Abnormality of the left ventricular outflow tract (HP:0011103)1.59756809
167Subaortic stenosis (HP:0001682)1.59756809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.87055777
2MAP3K43.20981432
3MAP3K93.08823943
4EPHA42.84594841
5NUAK12.73596592
6MARK12.62345143
7PRKD32.55377743
8NTRK22.49444057
9MAP2K72.16864055
10TXK2.10729959
11MINK12.08018721
12DAPK22.06739019
13MAP4K22.06091570
14CAMKK12.01227400
15PAK61.96928148
16ACVR1B1.96575544
17MAP2K41.84324699
18OBSCN1.79043412
19STK381.73412926
20PDK31.71266327
21PDK41.71266327
22CASK1.70403436
23CAMK1G1.65209563
24CAMKK21.61601360
25SCYL21.61060886
26TAOK31.49632782
27SGK21.47097863
28SGK31.43494851
29RIPK11.42476329
30LATS11.41780505
31TYRO31.39884162
32NTRK11.38541637
33TRIM281.37259608
34MAP3K21.36886021
35OXSR11.34837350
36CDK51.33136349
37KSR11.31303621
38PNCK1.28831255
39KSR21.28280753
40NLK1.27927835
41FRK1.27759921
42CAMK1D1.27524427
43FGFR21.23626812
44PRKCH1.23212956
45RIPK41.20849320
46BMPR1B1.18548944
47TEC1.18143692
48RET1.17782196
49SGK4941.17292425
50SGK2231.17292425
51LMTK21.16639452
52TRIB31.14454640
53YES11.12551075
54PHKG11.11589622
55PHKG21.11589622
56WNK11.10515872
57SIK21.07715043
58STK111.04896052
59ALK1.03659417
60PRPF4B1.00021221
61PDK10.99618972
62MAP3K120.97985990
63CDK30.97841691
64PLK20.96115926
65DAPK10.96085081
66PRKCG0.95859144
67SGK10.92491902
68STK390.91052052
69MKNK20.89085196
70ITK0.87996032
71MAPK130.86233044
72TNIK0.85199981
73ZAK0.85088190
74PTK2B0.85049314
75MAP3K130.84353331
76GRK50.83559113
77MAP4K10.83208267
78PDK20.82597603
79GRK60.81234304
80FGFR30.80984113
81MAP3K70.79182515
82PDPK10.78088440
83PRKCQ0.77175946
84CAMK10.75627538
85CSNK1G10.75590463
86FES0.74696670
87INSRR0.74228592
88PINK10.70642361
89CDK190.69280261
90RPS6KA30.67967840
91BCR0.66818373
92PAK30.64942581
93CAMK2A0.64685356
94BRSK20.64065088
95SYK0.62797317
96CDC42BPA0.62312840
97UHMK10.62202198
98FGR0.61823503
99BTK0.61602196
100TAOK10.60690750
101ADRBK20.57632806
102MAPK100.56840821
103DYRK1A0.56779483
104PIM10.54529087
105NEK10.53933942
106PDGFRA0.53643487
107PLK40.53082586
108HIPK20.53002448
109TNK20.52567598
110FER0.52390746
111CSNK1D0.52313839
112DMPK0.51892382
113JAK10.51825378
114AKT30.51717546
115PLK30.50844272
116WNK30.50833264
117PIK3CA0.50750630
118PRKCE0.50288263
119ERBB30.49918852
120FGFR10.49471542
121LCK0.49417462
122CDK150.48139833
123MARK30.48087341
124CDK180.47974695
125CAMK40.47524404
126PRKAA10.46952278
127STK38L0.46251695
128MARK20.45871160
129GRK10.45708890
130CDK140.45414396
131PKN10.45367250
132CSNK1G20.44748795
133PDGFRB0.44107970
134PKN20.43857408
135MAPK120.43851015
136CAMK2B0.43134964
137PIK3CG0.43065801
138RPS6KB10.43008566
139NEK60.41220382
140CCNB10.40444265
141FYN0.40272982
142PRKCB0.39230052
143PRKCZ0.39017780
144PTK60.38191677

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28066364
2Synaptic vesicle cycle_Homo sapiens_hsa047212.61254546
3GABAergic synapse_Homo sapiens_hsa047272.51849132
4Long-term potentiation_Homo sapiens_hsa047202.47049754
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36972753
6Circadian entrainment_Homo sapiens_hsa047132.34353333
7Glutamatergic synapse_Homo sapiens_hsa047242.32271245
8Morphine addiction_Homo sapiens_hsa050322.29662629
9Olfactory transduction_Homo sapiens_hsa047402.18222510
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07850315
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00560358
12Amphetamine addiction_Homo sapiens_hsa050311.98987069
13Salivary secretion_Homo sapiens_hsa049701.95993429
14Insulin secretion_Homo sapiens_hsa049111.90896008
15Dopaminergic synapse_Homo sapiens_hsa047281.84847411
16Primary immunodeficiency_Homo sapiens_hsa053401.77827963
17Gastric acid secretion_Homo sapiens_hsa049711.74256539
18Nitrogen metabolism_Homo sapiens_hsa009101.72342755
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68291353
20Regulation of autophagy_Homo sapiens_hsa041401.67994020
21Cholinergic synapse_Homo sapiens_hsa047251.67948795
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67488725
23Renin secretion_Homo sapiens_hsa049241.67192636
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66997387
25Taste transduction_Homo sapiens_hsa047421.66665054
26T cell receptor signaling pathway_Homo sapiens_hsa046601.63738190
27Long-term depression_Homo sapiens_hsa047301.62750860
28Type II diabetes mellitus_Homo sapiens_hsa049301.59426982
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57484886
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52444821
31Non-homologous end-joining_Homo sapiens_hsa034501.49187707
32Oxytocin signaling pathway_Homo sapiens_hsa049211.46479076
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39361644
34Calcium signaling pathway_Homo sapiens_hsa040201.32870857
35Butanoate metabolism_Homo sapiens_hsa006501.32600131
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30422798
37Propanoate metabolism_Homo sapiens_hsa006401.26621475
38Cocaine addiction_Homo sapiens_hsa050301.26537351
39cAMP signaling pathway_Homo sapiens_hsa040241.26269009
40Estrogen signaling pathway_Homo sapiens_hsa049151.24760592
41GnRH signaling pathway_Homo sapiens_hsa049121.23685528
42Fatty acid biosynthesis_Homo sapiens_hsa000611.20734779
43Serotonergic synapse_Homo sapiens_hsa047261.18271677
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15940242
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14086733
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14053266
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13108125
48Dorso-ventral axis formation_Homo sapiens_hsa043201.12523020
49Gap junction_Homo sapiens_hsa045401.12162559
50Glioma_Homo sapiens_hsa052141.10704901
51Phototransduction_Homo sapiens_hsa047441.07977484
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03181424
53mTOR signaling pathway_Homo sapiens_hsa041500.99061579
54ErbB signaling pathway_Homo sapiens_hsa040120.98675089
55Glucagon signaling pathway_Homo sapiens_hsa049220.95229554
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93101462
57Fanconi anemia pathway_Homo sapiens_hsa034600.92407869
58Pancreatic secretion_Homo sapiens_hsa049720.90930914
59Melanogenesis_Homo sapiens_hsa049160.90231212
60Thyroid hormone synthesis_Homo sapiens_hsa049180.89359875
61Dilated cardiomyopathy_Homo sapiens_hsa054140.89326077
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86844289
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86671941
64Oocyte meiosis_Homo sapiens_hsa041140.83985343
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83931487
66Ether lipid metabolism_Homo sapiens_hsa005650.82463770
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82439005
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81570819
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.79974964
70RNA degradation_Homo sapiens_hsa030180.79927942
71Inositol phosphate metabolism_Homo sapiens_hsa005620.79365504
72Circadian rhythm_Homo sapiens_hsa047100.78975846
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76153467
74Axon guidance_Homo sapiens_hsa043600.74643933
75Basal transcription factors_Homo sapiens_hsa030220.73929151
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73621338
77Collecting duct acid secretion_Homo sapiens_hsa049660.72709511
78ABC transporters_Homo sapiens_hsa020100.72620488
79MAPK signaling pathway_Homo sapiens_hsa040100.72451384
80Insulin signaling pathway_Homo sapiens_hsa049100.72056117
81Endometrial cancer_Homo sapiens_hsa052130.71020166
82Choline metabolism in cancer_Homo sapiens_hsa052310.70948415
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70643429
84Type I diabetes mellitus_Homo sapiens_hsa049400.69846957
85Linoleic acid metabolism_Homo sapiens_hsa005910.69536707
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68097921
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67715063
88Alcoholism_Homo sapiens_hsa050340.67237259
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.65711924
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64047365
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.63977278
92Platelet activation_Homo sapiens_hsa046110.63816992
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63224617
94Non-small cell lung cancer_Homo sapiens_hsa052230.58760713
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58636588
96Cardiac muscle contraction_Homo sapiens_hsa042600.57160999
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56773241
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56328625
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55530588
100Renal cell carcinoma_Homo sapiens_hsa052110.54676631
101Rap1 signaling pathway_Homo sapiens_hsa040150.53739335
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.53694341
103AMPK signaling pathway_Homo sapiens_hsa041520.53575307
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.52761992
105Insulin resistance_Homo sapiens_hsa049310.52503278
106Lysine degradation_Homo sapiens_hsa003100.52362766
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51217736
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51173892
109VEGF signaling pathway_Homo sapiens_hsa043700.50068445
110Bile secretion_Homo sapiens_hsa049760.50014403
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.49960831
112Measles_Homo sapiens_hsa051620.48817601
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47490546
114Colorectal cancer_Homo sapiens_hsa052100.47322068
115Wnt signaling pathway_Homo sapiens_hsa043100.45502652
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45221789
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.45088047
118Ras signaling pathway_Homo sapiens_hsa040140.44674524
119Ovarian steroidogenesis_Homo sapiens_hsa049130.44311227
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42427954
121Endocytosis_Homo sapiens_hsa041440.42134988
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42049952
123Vibrio cholerae infection_Homo sapiens_hsa051100.41943910
124Homologous recombination_Homo sapiens_hsa034400.40067543
125Prolactin signaling pathway_Homo sapiens_hsa049170.39923047
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.38936581
127Chemokine signaling pathway_Homo sapiens_hsa040620.38624189
128mRNA surveillance pathway_Homo sapiens_hsa030150.36934412
129Graft-versus-host disease_Homo sapiens_hsa053320.36346098
130FoxO signaling pathway_Homo sapiens_hsa040680.35845067
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33906376
132Glycerolipid metabolism_Homo sapiens_hsa005610.33590087
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32679428

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