

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.75901651 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.71561495 |
| 3 | locomotory exploration behavior (GO:0035641) | 5.52637062 |
| 4 | synaptic vesicle maturation (GO:0016188) | 5.49870187 |
| 5 | vocalization behavior (GO:0071625) | 5.27360394 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.23588103 |
| 7 | regulation of synapse structural plasticity (GO:0051823) | 5.18336256 |
| 8 | prepulse inhibition (GO:0060134) | 5.06915241 |
| 9 | synaptic vesicle exocytosis (GO:0016079) | 4.99585650 |
| 10 | cellular potassium ion homeostasis (GO:0030007) | 4.93579703 |
| 11 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.90043050 |
| 12 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.81003069 |
| 13 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.71864332 |
| 14 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.65011871 |
| 15 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.60685865 |
| 16 | synaptic transmission, dopaminergic (GO:0001963) | 4.60386304 |
| 17 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.51961400 |
| 18 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.50200682 |
| 19 | sodium ion export (GO:0071436) | 4.44380656 |
| 20 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.41285696 |
| 21 | protein localization to synapse (GO:0035418) | 4.38708313 |
| 22 | glutamate secretion (GO:0014047) | 4.37961451 |
| 23 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.31579940 |
| 24 | auditory behavior (GO:0031223) | 4.28841787 |
| 25 | neurotransmitter secretion (GO:0007269) | 4.24806777 |
| 26 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 4.21840996 |
| 27 | exploration behavior (GO:0035640) | 4.13955322 |
| 28 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 4.13161925 |
| 29 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.13021952 |
| 30 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 4.09957804 |
| 31 | neuron-neuron synaptic transmission (GO:0007270) | 4.08945014 |
| 32 | striatum development (GO:0021756) | 4.08808479 |
| 33 | neuron cell-cell adhesion (GO:0007158) | 4.06298166 |
| 34 | regulation of synaptic vesicle transport (GO:1902803) | 4.06239335 |
| 35 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 4.04143062 |
| 36 | synaptic transmission, glutamatergic (GO:0035249) | 4.01801816 |
| 37 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.98950377 |
| 38 | positive regulation of neurotransmitter transport (GO:0051590) | 3.98180533 |
| 39 | long-term memory (GO:0007616) | 3.95167828 |
| 40 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.94964174 |
| 41 | dendritic spine morphogenesis (GO:0060997) | 3.93564305 |
| 42 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.92004417 |
| 43 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.89145133 |
| 44 | adenosine receptor signaling pathway (GO:0001973) | 3.87856396 |
| 45 | cerebellar granule cell differentiation (GO:0021707) | 3.86625273 |
| 46 | neuronal action potential propagation (GO:0019227) | 3.86160160 |
| 47 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.84280459 |
| 48 | response to amphetamine (GO:0001975) | 3.84000394 |
| 49 | positive regulation of membrane potential (GO:0045838) | 3.83897260 |
| 50 | dopamine receptor signaling pathway (GO:0007212) | 3.81212381 |
| 51 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.80738553 |
| 52 | L-amino acid import (GO:0043092) | 3.80243359 |
| 53 | behavioral response to cocaine (GO:0048148) | 3.79533167 |
| 54 | regulation of glutamate secretion (GO:0014048) | 3.79485358 |
| 55 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.79323708 |
| 56 | layer formation in cerebral cortex (GO:0021819) | 3.78818449 |
| 57 | presynaptic membrane organization (GO:0097090) | 3.78274646 |
| 58 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.77867401 |
| 59 | response to auditory stimulus (GO:0010996) | 3.77075494 |
| 60 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.75340934 |
| 61 | positive regulation of dendritic spine development (GO:0060999) | 3.74575873 |
| 62 | response to histamine (GO:0034776) | 3.73862426 |
| 63 | regulation of synaptic plasticity (GO:0048167) | 3.72626440 |
| 64 | establishment of mitochondrion localization (GO:0051654) | 3.72117880 |
| 65 | glutamate receptor signaling pathway (GO:0007215) | 3.71249597 |
| 66 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.71017042 |
| 67 | gamma-aminobutyric acid transport (GO:0015812) | 3.70485420 |
| 68 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.69448703 |
| 69 | regulation of postsynaptic membrane potential (GO:0060078) | 3.67823807 |
| 70 | long-term synaptic potentiation (GO:0060291) | 3.65576112 |
| 71 | axonal fasciculation (GO:0007413) | 3.65188085 |
| 72 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.64370004 |
| 73 | synaptic vesicle endocytosis (GO:0048488) | 3.63422745 |
| 74 | presynaptic membrane assembly (GO:0097105) | 3.61693382 |
| 75 | cell migration in hindbrain (GO:0021535) | 3.61578076 |
| 76 | neuromuscular process controlling balance (GO:0050885) | 3.59758998 |
| 77 | transmission of nerve impulse (GO:0019226) | 3.54131540 |
| 78 | regulation of synapse maturation (GO:0090128) | 3.53895368 |
| 79 | activation of protein kinase A activity (GO:0034199) | 3.51930335 |
| 80 | potassium ion homeostasis (GO:0055075) | 3.49017532 |
| 81 | neuromuscular synaptic transmission (GO:0007274) | 3.48377191 |
| 82 | amino acid import (GO:0043090) | 3.47480678 |
| 83 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.47299222 |
| 84 | regulation of female receptivity (GO:0045924) | 3.44828755 |
| 85 | cell communication by electrical coupling (GO:0010644) | 3.42594720 |
| 86 | neuronal ion channel clustering (GO:0045161) | 3.41864897 |
| 87 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.41804681 |
| 88 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.41804681 |
| 89 | central nervous system myelination (GO:0022010) | 3.41532011 |
| 90 | axon ensheathment in central nervous system (GO:0032291) | 3.41532011 |
| 91 | membrane hyperpolarization (GO:0060081) | 3.34211511 |
| 92 | dendritic spine organization (GO:0097061) | 3.33102861 |
| 93 | behavioral defense response (GO:0002209) | 3.30662620 |
| 94 | behavioral fear response (GO:0001662) | 3.30662620 |
| 95 | mechanosensory behavior (GO:0007638) | 3.30362644 |
| 96 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.29508402 |
| 97 | visual learning (GO:0008542) | 3.29209149 |
| 98 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.28944127 |
| 99 | positive regulation of synapse maturation (GO:0090129) | 3.27588265 |
| 100 | neurotransmitter transport (GO:0006836) | 3.25467566 |
| 101 | cAMP catabolic process (GO:0006198) | 3.23374669 |
| 102 | membrane depolarization (GO:0051899) | 3.21989849 |
| 103 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.20606271 |
| 104 | regulation of neurotransmitter levels (GO:0001505) | 3.19639922 |
| 105 | membrane depolarization during action potential (GO:0086010) | 3.19415815 |
| 106 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.18695009 |
| 107 | positive regulation of synaptic transmission (GO:0050806) | 3.18684799 |
| 108 | regulation of dendritic spine development (GO:0060998) | 3.17728882 |
| 109 | proline transport (GO:0015824) | 3.15322181 |
| 110 | learning (GO:0007612) | 3.14622475 |
| 111 | synaptic transmission (GO:0007268) | 3.14024944 |
| 112 | potassium ion import (GO:0010107) | 3.13489292 |
| 113 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.12781516 |
| 114 | neuron recognition (GO:0008038) | 3.12461399 |
| 115 | regulation of neurotransmitter transport (GO:0051588) | 3.12043287 |
| 116 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.11801303 |
| 117 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.11801303 |
| 118 | magnesium ion transport (GO:0015693) | 3.11783481 |
| 119 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.11766262 |
| 120 | mitochondrion transport along microtubule (GO:0047497) | 3.11766262 |
| 121 | adult walking behavior (GO:0007628) | 3.11683473 |
| 122 | negative regulation of dendrite development (GO:2000171) | 3.11069614 |
| 123 | regulation of neurotransmitter secretion (GO:0046928) | 3.10964870 |
| 124 | nucleobase catabolic process (GO:0046113) | 3.10788779 |
| 125 | regulation of neurotransmitter uptake (GO:0051580) | 3.09806836 |
| 126 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.08419893 |
| 127 | regulation of ARF protein signal transduction (GO:0032012) | 3.08127124 |
| 128 | visual behavior (GO:0007632) | 3.07980377 |
| 129 | regulation of synaptic transmission (GO:0050804) | 3.05737680 |
| 130 | synaptic vesicle transport (GO:0048489) | 3.04330934 |
| 131 | establishment of synaptic vesicle localization (GO:0097480) | 3.04330934 |
| 132 | female mating behavior (GO:0060180) | 3.03152260 |
| 133 | regulation of Rap GTPase activity (GO:0032317) | 3.02788938 |
| 134 | postsynaptic membrane organization (GO:0001941) | 3.02500221 |
| 135 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.01222494 |
| 136 | regulation of vesicle fusion (GO:0031338) | 2.96986926 |
| 137 | fear response (GO:0042596) | 2.96473202 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.77483321 |
| 2 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.51366792 |
| 3 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.06604769 |
| 4 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.04945603 |
| 5 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.01274111 |
| 6 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.90940400 |
| 7 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.90646947 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.89491661 |
| 9 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.75402022 |
| 10 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.74663426 |
| 11 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.63677651 |
| 12 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.63677651 |
| 13 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.56359488 |
| 14 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.54931914 |
| 15 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.52642783 |
| 16 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.49870219 |
| 17 | * SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.43344705 |
| 18 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.37093428 |
| 19 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.33653367 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.33592173 |
| 21 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.33255461 |
| 22 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.26697769 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.24159917 |
| 24 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.14062690 |
| 25 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.06714258 |
| 26 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.99554505 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.95110990 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.90271992 |
| 29 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.86843959 |
| 30 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.72350107 |
| 31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.66722530 |
| 32 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.65020536 |
| 33 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.61628191 |
| 34 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.55073024 |
| 35 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.41898991 |
| 36 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.40472489 |
| 37 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.38178949 |
| 38 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.37646005 |
| 39 | KDM2B_26808549_Chip-Seq_K562_Human | 1.37320945 |
| 40 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.34371647 |
| 41 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.33772495 |
| 42 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.32313173 |
| 43 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.32271298 |
| 44 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.31893147 |
| 45 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.31792528 |
| 46 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.31147006 |
| 47 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.30727643 |
| 48 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.30488935 |
| 49 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.30440372 |
| 50 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.29652542 |
| 51 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.29479347 |
| 52 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.25878109 |
| 53 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.25468116 |
| 54 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.24852236 |
| 55 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.24848723 |
| 56 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.23198689 |
| 57 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.18416190 |
| 58 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.16870065 |
| 59 | AR_19668381_ChIP-Seq_PC3_Human | 1.16616015 |
| 60 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.14826012 |
| 61 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.13440313 |
| 62 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.12916141 |
| 63 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.10659128 |
| 64 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.10229527 |
| 65 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.09534833 |
| 66 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08957570 |
| 67 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.07980145 |
| 68 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05482170 |
| 69 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.04565174 |
| 70 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03290309 |
| 71 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01193880 |
| 72 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.00836444 |
| 73 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.00079440 |
| 74 | P300_19829295_ChIP-Seq_ESCs_Human | 0.99916337 |
| 75 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.99875257 |
| 76 | AR_25329375_ChIP-Seq_VCAP_Human | 0.99715799 |
| 77 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.99272305 |
| 78 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.99269432 |
| 79 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.98986292 |
| 80 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.97535659 |
| 81 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96448740 |
| 82 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.96448740 |
| 83 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.96403630 |
| 84 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.96367798 |
| 85 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.96365748 |
| 86 | RXR_22108803_ChIP-Seq_LS180_Human | 0.96350444 |
| 87 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.95970355 |
| 88 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94418275 |
| 89 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.94328153 |
| 90 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.93352118 |
| 91 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.92782392 |
| 92 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.92608160 |
| 93 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.92258211 |
| 94 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.91850250 |
| 95 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.90115891 |
| 96 | TP53_16413492_ChIP-PET_HCT116_Human | 0.88174139 |
| 97 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.87987810 |
| 98 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.87448667 |
| 99 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.86613756 |
| 100 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85856403 |
| 101 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.85691159 |
| 102 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.85649811 |
| 103 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.85610909 |
| 104 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.85024145 |
| 105 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.84465981 |
| 106 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.84404505 |
| 107 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84036552 |
| 108 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.84003628 |
| 109 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.83468087 |
| 110 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.82720294 |
| 111 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.82343766 |
| 112 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.81181112 |
| 113 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.80532158 |
| 114 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.79639985 |
| 115 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.79243985 |
| 116 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.78927881 |
| 117 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.78647207 |
| 118 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.78493835 |
| 119 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.77295102 |
| 120 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.77056588 |
| 121 | JUN_21703547_ChIP-Seq_K562_Human | 0.75975408 |
| 122 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.75378314 |
| 123 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.74068999 |
| 124 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.74030765 |
| 125 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.73793509 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.73567295 |
| 2 | MP0002822_catalepsy | 6.29338068 |
| 3 | MP0003880_abnormal_central_pattern | 4.75025483 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 4.23504415 |
| 5 | MP0009745_abnormal_behavioral_response | 3.69885211 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.69283342 |
| 7 | MP0004270_analgesia | 3.30576240 |
| 8 | MP0002064_seizures | 3.18263024 |
| 9 | MP0002572_abnormal_emotion/affect_behav | 3.11204203 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.84018118 |
| 11 | MP0009046_muscle_twitch | 2.79885341 |
| 12 | MP0001968_abnormal_touch/_nociception | 2.77972256 |
| 13 | MP0001486_abnormal_startle_reflex | 2.65383647 |
| 14 | MP0002272_abnormal_nervous_system | 2.42583360 |
| 15 | MP0002909_abnormal_adrenal_gland | 2.31401564 |
| 16 | MP0001529_abnormal_vocalization | 2.22159220 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.11548842 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.07342703 |
| 19 | MP0002736_abnormal_nociception_after | 2.05622829 |
| 20 | MP0002557_abnormal_social/conspecific_i | 1.99854489 |
| 21 | MP0005646_abnormal_pituitary_gland | 1.92661625 |
| 22 | MP0001440_abnormal_grooming_behavior | 1.92023129 |
| 23 | MP0002733_abnormal_thermal_nociception | 1.89243873 |
| 24 | MP0001970_abnormal_pain_threshold | 1.84041319 |
| 25 | MP0004924_abnormal_behavior | 1.83221545 |
| 26 | MP0005386_behavior/neurological_phenoty | 1.83221545 |
| 27 | MP0008569_lethality_at_weaning | 1.81972004 |
| 28 | MP0003123_paternal_imprinting | 1.78693969 |
| 29 | MP0004811_abnormal_neuron_physiology | 1.74228802 |
| 30 | MP0009780_abnormal_chondrocyte_physiolo | 1.71393443 |
| 31 | MP0002735_abnormal_chemical_nociception | 1.68827643 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.67243155 |
| 33 | MP0001984_abnormal_olfaction | 1.61959536 |
| 34 | MP0003879_abnormal_hair_cell | 1.59021424 |
| 35 | MP0003329_amyloid_beta_deposits | 1.57226791 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.53044347 |
| 37 | MP0002184_abnormal_innervation | 1.48665461 |
| 38 | MP0003303_peritoneal_inflammation | 1.47020119 |
| 39 | MP0008961_abnormal_basal_metabolism | 1.45162040 |
| 40 | MP0000778_abnormal_nervous_system | 1.43530136 |
| 41 | MP0003121_genomic_imprinting | 1.42026066 |
| 42 | MP0001905_abnormal_dopamine_level | 1.37421718 |
| 43 | MP0000955_abnormal_spinal_cord | 1.35567124 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.35480172 |
| 45 | MP0008872_abnormal_physiological_respon | 1.30501324 |
| 46 | MP0005409_darkened_coat_color | 1.29471954 |
| 47 | MP0003787_abnormal_imprinting | 1.28130423 |
| 48 | MP0003633_abnormal_nervous_system | 1.27738619 |
| 49 | MP0004885_abnormal_endolymph | 1.23866705 |
| 50 | MP0005645_abnormal_hypothalamus_physiol | 1.22762896 |
| 51 | MP0008874_decreased_physiological_sensi | 1.22738905 |
| 52 | MP0002882_abnormal_neuron_morphology | 1.19135314 |
| 53 | MP0008877_abnormal_DNA_methylation | 1.18564784 |
| 54 | MP0004858_abnormal_nervous_system | 1.16759759 |
| 55 | MP0002638_abnormal_pupillary_reflex | 1.12579781 |
| 56 | MP0003122_maternal_imprinting | 1.11652212 |
| 57 | MP0006276_abnormal_autonomic_nervous | 1.11078063 |
| 58 | MP0001188_hyperpigmentation | 1.07938478 |
| 59 | MP0003075_altered_response_to | 1.05481089 |
| 60 | MP0001502_abnormal_circadian_rhythm | 1.05372658 |
| 61 | MP0004142_abnormal_muscle_tone | 1.02496979 |
| 62 | MP0002069_abnormal_eating/drinking_beha | 1.01350922 |
| 63 | MP0005551_abnormal_eye_electrophysiolog | 1.01276020 |
| 64 | MP0004742_abnormal_vestibular_system | 1.01180074 |
| 65 | MP0001177_atelectasis | 0.99811008 |
| 66 | MP0003631_nervous_system_phenotype | 0.98600993 |
| 67 | MP0002152_abnormal_brain_morphology | 0.96647358 |
| 68 | MP0005535_abnormal_body_temperature | 0.92098192 |
| 69 | MP0002653_abnormal_ependyma_morphology | 0.91909490 |
| 70 | MP0001986_abnormal_taste_sensitivity | 0.89786665 |
| 71 | MP0004085_abnormal_heartbeat | 0.89396884 |
| 72 | MP0003690_abnormal_glial_cell | 0.87205832 |
| 73 | MP0000751_myopathy | 0.86514235 |
| 74 | MP0000013_abnormal_adipose_tissue | 0.86173837 |
| 75 | MP0004147_increased_porphyrin_level | 0.84056273 |
| 76 | MP0000569_abnormal_digit_pigmentation | 0.82502034 |
| 77 | MP0005499_abnormal_olfactory_system | 0.80729249 |
| 78 | MP0005394_taste/olfaction_phenotype | 0.80729249 |
| 79 | MP0001348_abnormal_lacrimal_gland | 0.78088097 |
| 80 | MP0001485_abnormal_pinna_reflex | 0.77545304 |
| 81 | MP0000631_abnormal_neuroendocrine_gland | 0.74562708 |
| 82 | MP0003861_abnormal_nervous_system | 0.73739935 |
| 83 | MP0000920_abnormal_myelination | 0.73018255 |
| 84 | MP0000604_amyloidosis | 0.72067302 |
| 85 | MP0010234_abnormal_vibrissa_follicle | 0.71753984 |
| 86 | MP0005167_abnormal_blood-brain_barrier | 0.71166878 |
| 87 | MP0004510_myositis | 0.70301599 |
| 88 | MP0001943_abnormal_respiration | 0.67574478 |
| 89 | MP0000026_abnormal_inner_ear | 0.67272698 |
| 90 | MP0003183_abnormal_peptide_metabolism | 0.66746360 |
| 91 | MP0002229_neurodegeneration | 0.66613623 |
| 92 | MP0003172_abnormal_lysosome_physiology | 0.65181471 |
| 93 | MP0001346_abnormal_lacrimal_gland | 0.64520119 |
| 94 | MP0003634_abnormal_glial_cell | 0.61706584 |
| 95 | MP0002090_abnormal_vision | 0.61582980 |
| 96 | MP0003938_abnormal_ear_development | 0.61224103 |
| 97 | MP0003283_abnormal_digestive_organ | 0.61166541 |
| 98 | MP0004130_abnormal_muscle_cell | 0.61111459 |
| 99 | MP0005166_decreased_susceptibility_to | 0.56790633 |
| 100 | MP0001299_abnormal_eye_distance/ | 0.56182166 |
| 101 | MP0001963_abnormal_hearing_physiology | 0.55151866 |
| 102 | MP0004133_heterotaxia | 0.54967483 |
| 103 | MP0005187_abnormal_penis_morphology | 0.51126954 |
| 104 | MP0003137_abnormal_impulse_conducting | 0.50897814 |
| 105 | MP0003632_abnormal_nervous_system | 0.49739673 |
| 106 | MP0010769_abnormal_survival | 0.48007719 |
| 107 | MP0003956_abnormal_body_size | 0.46384489 |
| 108 | MP0002752_abnormal_somatic_nervous | 0.46284766 |
| 109 | MP0005623_abnormal_meninges_morphology | 0.45121284 |
| 110 | MP0010770_preweaning_lethality | 0.44679406 |
| 111 | MP0002082_postnatal_lethality | 0.44679406 |
| 112 | MP0010768_mortality/aging | 0.44447421 |
| 113 | MP0001664_abnormal_digestion | 0.44267713 |
| 114 | MP0001790_abnormal_immune_system | 0.43053705 |
| 115 | MP0005387_immune_system_phenotype | 0.43053705 |
| 116 | MP0005448_abnormal_energy_balance | 0.41546516 |
| 117 | MP0010386_abnormal_urinary_bladder | 0.41390056 |
| 118 | MP0005310_abnormal_salivary_gland | 0.39778232 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 8.14603839 |
| 2 | Focal motor seizures (HP:0011153) | 7.66013314 |
| 3 | Focal seizures (HP:0007359) | 5.79544235 |
| 4 | Visual hallucinations (HP:0002367) | 4.66195313 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.27810781 |
| 6 | Poor eye contact (HP:0000817) | 3.88209071 |
| 7 | Febrile seizures (HP:0002373) | 3.86623389 |
| 8 | Atonic seizures (HP:0010819) | 3.75355040 |
| 9 | Annular pancreas (HP:0001734) | 3.71661470 |
| 10 | Torticollis (HP:0000473) | 3.69301608 |
| 11 | Ankle clonus (HP:0011448) | 3.67663291 |
| 12 | Broad-based gait (HP:0002136) | 3.65189051 |
| 13 | Abnormal social behavior (HP:0012433) | 3.59334817 |
| 14 | Impaired social interactions (HP:0000735) | 3.59334817 |
| 15 | Absence seizures (HP:0002121) | 3.59211883 |
| 16 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.54248273 |
| 17 | Abnormal eating behavior (HP:0100738) | 3.52987493 |
| 18 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.52382095 |
| 19 | Generalized tonic-clonic seizures (HP:0002069) | 3.49216208 |
| 20 | Depression (HP:0000716) | 3.48765594 |
| 21 | Hyperventilation (HP:0002883) | 3.35211470 |
| 22 | Anxiety (HP:0000739) | 3.35184415 |
| 23 | Dialeptic seizures (HP:0011146) | 3.33670435 |
| 24 | Action tremor (HP:0002345) | 3.33283789 |
| 25 | Progressive cerebellar ataxia (HP:0002073) | 3.31785994 |
| 26 | Focal dystonia (HP:0004373) | 3.26296863 |
| 27 | Supranuclear gaze palsy (HP:0000605) | 3.26235036 |
| 28 | Urinary urgency (HP:0000012) | 3.23407825 |
| 29 | Dysdiadochokinesis (HP:0002075) | 3.21630406 |
| 30 | Truncal ataxia (HP:0002078) | 3.19869307 |
| 31 | Resting tremor (HP:0002322) | 3.17064361 |
| 32 | Craniofacial dystonia (HP:0012179) | 3.10997176 |
| 33 | Stereotypic behavior (HP:0000733) | 3.05775422 |
| 34 | Gaze-evoked nystagmus (HP:0000640) | 3.03081383 |
| 35 | Dysmetric saccades (HP:0000641) | 3.00431019 |
| 36 | Dysmetria (HP:0001310) | 3.00232139 |
| 37 | Postural instability (HP:0002172) | 2.96667097 |
| 38 | Papilledema (HP:0001085) | 2.92799032 |
| 39 | Akinesia (HP:0002304) | 2.90761748 |
| 40 | Lower limb amyotrophy (HP:0007210) | 2.87326214 |
| 41 | Spastic gait (HP:0002064) | 2.86811139 |
| 42 | Cerebral hypomyelination (HP:0006808) | 2.85238575 |
| 43 | Progressive inability to walk (HP:0002505) | 2.72076395 |
| 44 | Amblyopia (HP:0000646) | 2.67715258 |
| 45 | Limb dystonia (HP:0002451) | 2.67221431 |
| 46 | Impaired smooth pursuit (HP:0007772) | 2.65441793 |
| 47 | Tetraplegia (HP:0002445) | 2.62436056 |
| 48 | Mutism (HP:0002300) | 2.62300075 |
| 49 | Abnormality of binocular vision (HP:0011514) | 2.59999602 |
| 50 | Diplopia (HP:0000651) | 2.59999602 |
| 51 | Pointed chin (HP:0000307) | 2.57827034 |
| 52 | Abnormality of the lower motor neuron (HP:0002366) | 2.57279965 |
| 53 | Delusions (HP:0000746) | 2.53920246 |
| 54 | Agammaglobulinemia (HP:0004432) | 2.52765944 |
| 55 | Scanning speech (HP:0002168) | 2.52705308 |
| 56 | Peripheral hypomyelination (HP:0007182) | 2.51369446 |
| 57 | Hemiplegia (HP:0002301) | 2.51257105 |
| 58 | Bradykinesia (HP:0002067) | 2.44599943 |
| 59 | Drooling (HP:0002307) | 2.43629627 |
| 60 | Excessive salivation (HP:0003781) | 2.43629627 |
| 61 | Ankyloglossia (HP:0010296) | 2.38274101 |
| 62 | Apathy (HP:0000741) | 2.36003175 |
| 63 | Polyphagia (HP:0002591) | 2.35944645 |
| 64 | Impaired vibratory sensation (HP:0002495) | 2.30821624 |
| 65 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.29330130 |
| 66 | Failure to thrive in infancy (HP:0001531) | 2.24392342 |
| 67 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.23567321 |
| 68 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.23567321 |
| 69 | Hemiparesis (HP:0001269) | 2.22990888 |
| 70 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.21353929 |
| 71 | Epileptiform EEG discharges (HP:0011182) | 2.20231796 |
| 72 | Lower limb muscle weakness (HP:0007340) | 2.19869870 |
| 73 | Spastic tetraplegia (HP:0002510) | 2.19030317 |
| 74 | Genetic anticipation (HP:0003743) | 2.18971257 |
| 75 | Intention tremor (HP:0002080) | 2.17489425 |
| 76 | Gait imbalance (HP:0002141) | 2.16910703 |
| 77 | Diminished motivation (HP:0000745) | 2.16435293 |
| 78 | Absent speech (HP:0001344) | 2.16227322 |
| 79 | Status epilepticus (HP:0002133) | 2.16226561 |
| 80 | Amyotrophic lateral sclerosis (HP:0007354) | 2.14766830 |
| 81 | Abnormal EKG (HP:0003115) | 2.12322770 |
| 82 | Split foot (HP:0001839) | 2.10869708 |
| 83 | Verrucae (HP:0200043) | 2.10764362 |
| 84 | Papilloma (HP:0012740) | 2.10764362 |
| 85 | CNS hypomyelination (HP:0003429) | 2.09573169 |
| 86 | Cerebral inclusion bodies (HP:0100314) | 2.09213879 |
| 87 | Megalencephaly (HP:0001355) | 2.09161181 |
| 88 | EEG with generalized epileptiform discharges (HP:0011198) | 2.08461918 |
| 89 | Neurofibrillary tangles (HP:0002185) | 2.08398728 |
| 90 | Ventricular fibrillation (HP:0001663) | 2.07641668 |
| 91 | Clonus (HP:0002169) | 2.05964282 |
| 92 | Incomplete penetrance (HP:0003829) | 2.03850100 |
| 93 | Hypsarrhythmia (HP:0002521) | 2.03032505 |
| 94 | Spinal canal stenosis (HP:0003416) | 2.02782086 |
| 95 | Distal lower limb amyotrophy (HP:0008944) | 2.02643365 |
| 96 | Insomnia (HP:0100785) | 2.01417670 |
| 97 | Obstructive sleep apnea (HP:0002870) | 2.00831077 |
| 98 | Abnormality of the corticospinal tract (HP:0002492) | 2.00189844 |
| 99 | Neoplasm of the heart (HP:0100544) | 2.00095820 |
| 100 | Generalized hypotonia (HP:0001290) | 1.99446035 |
| 101 | Abnormality of saccadic eye movements (HP:0000570) | 1.98223475 |
| 102 | Neuronal loss in central nervous system (HP:0002529) | 1.96956655 |
| 103 | Spastic tetraparesis (HP:0001285) | 1.96730880 |
| 104 | Deep palmar crease (HP:0006191) | 1.95889764 |
| 105 | Fetal akinesia sequence (HP:0001989) | 1.94083612 |
| 106 | Agitation (HP:0000713) | 1.93380366 |
| 107 | Inability to walk (HP:0002540) | 1.92613274 |
| 108 | Sleep apnea (HP:0010535) | 1.92598797 |
| 109 | Insidious onset (HP:0003587) | 1.92496829 |
| 110 | Termporal pattern (HP:0011008) | 1.92496829 |
| 111 | Hypoplasia of the corpus callosum (HP:0002079) | 1.91833121 |
| 112 | Specific learning disability (HP:0001328) | 1.90455383 |
| 113 | Lower limb asymmetry (HP:0100559) | 1.90233952 |
| 114 | Prolonged QT interval (HP:0001657) | 1.89788309 |
| 115 | Abnormality of oral frenula (HP:0000190) | 1.88671759 |
| 116 | Psychosis (HP:0000709) | 1.85530726 |
| 117 | Poor suck (HP:0002033) | 1.85048883 |
| 118 | Rapidly progressive (HP:0003678) | 1.84811988 |
| 119 | Rigidity (HP:0002063) | 1.81985439 |
| 120 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.78318480 |
| 121 | Iris hypopigmentation (HP:0007730) | 1.78268730 |
| 122 | Hypoventilation (HP:0002791) | 1.77819356 |
| 123 | Abnormality of the labia minora (HP:0012880) | 1.76261277 |
| 124 | Paraplegia (HP:0010550) | 1.73027272 |
| 125 | Choreoathetosis (HP:0001266) | 1.71464241 |
| 126 | Hypoplasia of the brainstem (HP:0002365) | 1.71204395 |
| 127 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.71204395 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.94889196 |
| 2 | MAP3K9 | 4.15989624 |
| 3 | NTRK3 | 3.86744325 |
| 4 | DAPK2 | 2.74056416 |
| 5 | RIPK4 | 2.68002147 |
| 6 | MARK1 | 2.48614633 |
| 7 | MAP3K4 | 2.22450381 |
| 8 | MINK1 | 2.20466817 |
| 9 | KSR2 | 2.17807827 |
| 10 | SIK2 | 2.07412569 |
| 11 | CAMKK1 | 1.94096229 |
| 12 | NTRK2 | 1.90786230 |
| 13 | MAP4K1 | 1.87579200 |
| 14 | PAK6 | 1.85967355 |
| 15 | FES | 1.84508830 |
| 16 | PRKD3 | 1.79829606 |
| 17 | MAP3K13 | 1.78929285 |
| 18 | TAOK1 | 1.76905116 |
| 19 | MAP2K7 | 1.75049609 |
| 20 | KSR1 | 1.73296315 |
| 21 | DAPK1 | 1.64104522 |
| 22 | MAP3K12 | 1.63600237 |
| 23 | CDK5 | 1.63214833 |
| 24 | CDK19 | 1.59952416 |
| 25 | CASK | 1.54805497 |
| 26 | PRPF4B | 1.48717388 |
| 27 | ARAF | 1.48550031 |
| 28 | NTRK1 | 1.45673227 |
| 29 | SIK3 | 1.45250269 |
| 30 | PAK3 | 1.41407442 |
| 31 | LATS2 | 1.34218303 |
| 32 | TNIK | 1.24882990 |
| 33 | MAP2K4 | 1.20979364 |
| 34 | PRKCH | 1.19859194 |
| 35 | DYRK2 | 1.18025400 |
| 36 | STK11 | 1.08555674 |
| 37 | MARK2 | 1.04045569 |
| 38 | TNK2 | 1.01865119 |
| 39 | SGK223 | 0.98775320 |
| 40 | SGK494 | 0.98775320 |
| 41 | UHMK1 | 0.95276068 |
| 42 | SGK3 | 0.94897121 |
| 43 | ALK | 0.94392430 |
| 44 | SGK2 | 0.92824178 |
| 45 | RAF1 | 0.92512592 |
| 46 | STK38 | 0.92356814 |
| 47 | MAP3K2 | 0.91719645 |
| 48 | MAPK13 | 0.91032272 |
| 49 | GRK5 | 0.88018762 |
| 50 | TYRO3 | 0.87903412 |
| 51 | PRKCG | 0.87632682 |
| 52 | CDK18 | 0.87287353 |
| 53 | CAMKK2 | 0.86053376 |
| 54 | PDK1 | 0.82945806 |
| 55 | PKN1 | 0.82479862 |
| 56 | CDK15 | 0.82452812 |
| 57 | PLK2 | 0.81785373 |
| 58 | BMPR2 | 0.81270944 |
| 59 | CAMK1 | 0.76921004 |
| 60 | LIMK1 | 0.76619193 |
| 61 | PRKD2 | 0.76195431 |
| 62 | CAMK2A | 0.75799641 |
| 63 | SYK | 0.74736694 |
| 64 | BCR | 0.74687573 |
| 65 | CDK14 | 0.74028100 |
| 66 | CDK11A | 0.72742761 |
| 67 | SGK1 | 0.70392605 |
| 68 | PDPK1 | 0.69934224 |
| 69 | FYN | 0.65839651 |
| 70 | RET | 0.64886428 |
| 71 | MAP3K1 | 0.64841896 |
| 72 | PTK2B | 0.64151283 |
| 73 | NEK6 | 0.62977183 |
| 74 | CAMK2B | 0.62343232 |
| 75 | CSNK1G2 | 0.61992320 |
| 76 | DAPK3 | 0.61981103 |
| 77 | CAMK2G | 0.61951577 |
| 78 | GRK6 | 0.60846238 |
| 79 | MAP2K1 | 0.59132858 |
| 80 | TRIB3 | 0.58884027 |
| 81 | MAP3K11 | 0.58652195 |
| 82 | BRSK1 | 0.56922086 |
| 83 | PHKG2 | 0.55127190 |
| 84 | PHKG1 | 0.55127190 |
| 85 | CSNK1G3 | 0.54227288 |
| 86 | LMTK2 | 0.53577988 |
| 87 | PRKCZ | 0.52724959 |
| 88 | CSNK1A1L | 0.52574717 |
| 89 | PINK1 | 0.52117094 |
| 90 | FGR | 0.48568443 |
| 91 | CAMK4 | 0.47884585 |
| 92 | RPS6KA3 | 0.46950687 |
| 93 | RIPK1 | 0.45942520 |
| 94 | HCK | 0.42897192 |
| 95 | DYRK1B | 0.42571440 |
| 96 | RPS6KA2 | 0.42118208 |
| 97 | PRKCQ | 0.41943833 |
| 98 | CDC42BPA | 0.41770729 |
| 99 | MAPK12 | 0.37888317 |
| 100 | CAMK2D | 0.37887858 |
| 101 | MAPK10 | 0.37430340 |
| 102 | CSNK1E | 0.37305998 |
| 103 | TESK1 | 0.36614404 |
| 104 | PRKCB | 0.36409760 |
| 105 | MAP3K7 | 0.36322692 |
| 106 | CLK1 | 0.36283646 |
| 107 | OXSR1 | 0.36050917 |
| 108 | MAPK7 | 0.36036267 |
| 109 | DYRK1A | 0.35583433 |
| 110 | PRKCA | 0.35137946 |
| 111 | CAMK1G | 0.34602284 |
| 112 | JAK1 | 0.34535916 |
| 113 | FGFR2 | 0.33678867 |
| 114 | * PRKACA | 0.33311362 |
| 115 | DMPK | 0.33158860 |
| 116 | CSNK1A1 | 0.32719274 |
| 117 | BRAF | 0.32678501 |
| 118 | CSNK1D | 0.32594104 |
| 119 | PRKCE | 0.32498913 |
| 120 | PNCK | 0.32400317 |
| 121 | PRKG1 | 0.32002280 |
| 122 | CCNB1 | 0.31923406 |
| 123 | ERBB2 | 0.31624050 |
| 124 | BMX | 0.31454422 |
| 125 | CSNK1G1 | 0.30761528 |
| 126 | WNK3 | 0.30367967 |
| 127 | TRIM28 | 0.29633251 |
| 128 | MAPK8 | 0.28398210 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.15249966 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.14595129 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.00537250 |
| 4 | Morphine addiction_Homo sapiens_hsa05032 | 2.73845637 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.68503066 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.62616241 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.54649008 |
| 8 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.50042358 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.41053607 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.39799364 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.26406320 |
| 12 | Cocaine addiction_Homo sapiens_hsa05030 | 2.24949781 |
| 13 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.00592103 |
| 14 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.99767936 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 1.97475224 |
| 16 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.89818757 |
| 17 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.84870852 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.77251632 |
| 19 | Insulin secretion_Homo sapiens_hsa04911 | 1.74827482 |
| 20 | Renin secretion_Homo sapiens_hsa04924 | 1.74708168 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.68616691 |
| 22 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.64211919 |
| 23 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.57685715 |
| 24 | Long-term depression_Homo sapiens_hsa04730 | 1.54211055 |
| 25 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.50333274 |
| 26 | Gap junction_Homo sapiens_hsa04540 | 1.45818387 |
| 27 | Taste transduction_Homo sapiens_hsa04742 | 1.43699256 |
| 28 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.36537982 |
| 29 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.27109908 |
| 30 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.26850669 |
| 31 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.18999386 |
| 32 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.18842740 |
| 33 | Glioma_Homo sapiens_hsa05214 | 1.18201389 |
| 34 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.18058942 |
| 35 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.12596351 |
| 36 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.11313322 |
| 37 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.09597081 |
| 38 | Axon guidance_Homo sapiens_hsa04360 | 1.04644913 |
| 39 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.02867830 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.02448482 |
| 41 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.02336576 |
| 42 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.00098437 |
| 43 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.97468871 |
| 44 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.96599943 |
| 45 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.95810110 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.94936459 |
| 47 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.93182136 |
| 48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.92250631 |
| 49 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.88067540 |
| 50 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.85672981 |
| 51 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.83422045 |
| 52 | Melanogenesis_Homo sapiens_hsa04916 | 0.83417034 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.82389214 |
| 54 | * MAPK signaling pathway_Homo sapiens_hsa04010 | 0.81119288 |
| 55 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.80736706 |
| 56 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.78646236 |
| 57 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.76898349 |
| 58 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.76064780 |
| 59 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.75402753 |
| 60 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73171285 |
| 61 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.69608287 |
| 62 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.68792518 |
| 63 | Alcoholism_Homo sapiens_hsa05034 | 0.67445200 |
| 64 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.66383260 |
| 65 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.66281945 |
| 66 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.66078681 |
| 67 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.64972573 |
| 68 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.63605115 |
| 69 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.63108259 |
| 70 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.62615499 |
| 71 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.61085047 |
| 72 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.60394604 |
| 73 | Alzheimers disease_Homo sapiens_hsa05010 | 0.59938318 |
| 74 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57372654 |
| 75 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.56464979 |
| 76 | Endocytosis_Homo sapiens_hsa04144 | 0.55394475 |
| 77 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.54639989 |
| 78 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.53981366 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.53920605 |
| 80 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.52494735 |
| 81 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.52162685 |
| 82 | Endometrial cancer_Homo sapiens_hsa05213 | 0.51384669 |
| 83 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.50170839 |
| 84 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.49787951 |
| 85 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49475475 |
| 86 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.49026907 |
| 87 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.48873685 |
| 88 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.48752105 |
| 89 | Platelet activation_Homo sapiens_hsa04611 | 0.47298902 |
| 90 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.46799120 |
| 91 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.46185630 |
| 92 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.45796473 |
| 93 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.44782448 |
| 94 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.44205961 |
| 95 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.41404417 |
| 96 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.40941176 |
| 97 | Circadian rhythm_Homo sapiens_hsa04710 | 0.40193089 |
| 98 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.38611983 |
| 99 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.38611396 |
| 100 | Bile secretion_Homo sapiens_hsa04976 | 0.37044207 |
| 101 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.36401152 |
| 102 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.35845647 |
| 103 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.34709609 |
| 104 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.34098982 |
| 105 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.33752080 |
| 106 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.33452519 |
| 107 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.33407163 |
| 108 | Parkinsons disease_Homo sapiens_hsa05012 | 0.32561738 |
| 109 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.32232976 |
| 110 | Prion diseases_Homo sapiens_hsa05020 | 0.32109046 |
| 111 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32105685 |
| 112 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30506888 |
| 113 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.29602628 |
| 114 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.28252190 |
| 115 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.26813991 |
| 116 | Tight junction_Homo sapiens_hsa04530 | 0.26663062 |
| 117 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.19248822 |
| 118 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.18617379 |
| 119 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18360644 |

