PTPN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.71422380
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59713539
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.43426884
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.43426884
5positive regulation of gamma-delta T cell activation (GO:0046645)5.42170279
6detection of other organism (GO:0098543)4.64439969
7detection of bacterium (GO:0016045)4.62483241
8immunoglobulin mediated immune response (GO:0016064)4.55708944
9* regulation of B cell receptor signaling pathway (GO:0050855)4.48306128
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.36127229
11positive regulation of B cell differentiation (GO:0045579)4.23731918
12* B cell receptor signaling pathway (GO:0050853)4.21354839
13negative regulation of interleukin-12 production (GO:0032695)4.09542808
14regulation of gamma-delta T cell differentiation (GO:0045586)4.06234940
15leukocyte aggregation (GO:0070486)4.05530726
16* regulation of B cell differentiation (GO:0045577)3.99681488
17regulation of gamma-delta T cell activation (GO:0046643)3.81642826
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.80428052
19B cell mediated immunity (GO:0019724)3.76893303
20detection of external biotic stimulus (GO:0098581)3.75575496
21response to host immune response (GO:0052572)3.64141684
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64141684
23positive thymic T cell selection (GO:0045059)3.62872247
24negative regulation of phagocytosis (GO:0050765)3.62117648
25regulation of mast cell degranulation (GO:0043304)3.61838492
26interferon-gamma production (GO:0032609)3.56199404
27antigen processing and presentation via MHC class Ib (GO:0002475)3.54930215
28negative thymic T cell selection (GO:0045060)3.53491111
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53148190
30cellular response to zinc ion (GO:0071294)3.52734267
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52287724
32negative regulation of cell killing (GO:0031342)3.52287724
33negative regulation of T cell mediated immunity (GO:0002710)3.49582273
34respiratory burst (GO:0045730)3.49313387
35* negative regulation of lymphocyte mediated immunity (GO:0002707)3.48626235
36regulation of interferon-beta biosynthetic process (GO:0045357)3.47272682
37defense response to protozoan (GO:0042832)3.45370128
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.44796031
39negative regulation of erythrocyte differentiation (GO:0045647)3.42522069
40negative T cell selection (GO:0043383)3.41492402
41response to interleukin-15 (GO:0070672)3.34879491
42neutrophil activation involved in immune response (GO:0002283)3.33935184
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.33053738
44response to host (GO:0075136)3.33053738
45response to host defenses (GO:0052200)3.33053738
46* negative regulation of leukocyte mediated immunity (GO:0002704)3.31294250
47regulation of mast cell activation involved in immune response (GO:0033006)3.30859178
48detection of biotic stimulus (GO:0009595)3.29691546
49microglial cell activation (GO:0001774)3.28254213
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27683120
51cellular response to interleukin-15 (GO:0071350)3.27483407
52response to peptidoglycan (GO:0032494)3.25784240
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25654434
54response to protozoan (GO:0001562)3.21773500
55T cell migration (GO:0072678)3.18924463
56mast cell activation (GO:0045576)3.18630280
57NIK/NF-kappaB signaling (GO:0038061)3.18222944
58positive regulation of interferon-alpha production (GO:0032727)3.17995711
59* interferon-gamma-mediated signaling pathway (GO:0060333)3.17768102
60regulation of leukocyte degranulation (GO:0043300)3.16976545
61ribosomal small subunit assembly (GO:0000028)3.16714771
62regulation of T cell tolerance induction (GO:0002664)3.16286926
63detection of molecule of bacterial origin (GO:0032490)3.16266069
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.13760192
65mature B cell differentiation (GO:0002335)3.13447429
66positive regulation of antigen processing and presentation (GO:0002579)3.09599032
67* response to type I interferon (GO:0034340)3.09079031
68* type I interferon signaling pathway (GO:0060337)3.08690871
69* cellular response to type I interferon (GO:0071357)3.08690871
70mature B cell differentiation involved in immune response (GO:0002313)3.08637230
71leukocyte degranulation (GO:0043299)3.06314981
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.05159786
73regulation of tolerance induction (GO:0002643)3.05156816
74* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.04953330
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.02542038
76regulation of natural killer cell mediated immunity (GO:0002715)3.02542038
77macrophage activation (GO:0042116)3.01589604
78regulation of interferon-alpha production (GO:0032647)3.00196467
79tolerance induction (GO:0002507)2.99191480
80modulation by symbiont of host immune response (GO:0052553)2.98500265
81positive regulation by symbiont of host defense response (GO:0052509)2.98500265
82modulation by symbiont of host defense response (GO:0052031)2.98500265
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98500265
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98500265
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.98500265
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98093147
87regulation of T cell mediated cytotoxicity (GO:0001914)2.98028066
88thymic T cell selection (GO:0045061)2.96868990
89negative regulation of innate immune response (GO:0045824)2.95634471
90cellular extravasation (GO:0045123)2.94164359
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93405099
92neutrophil mediated immunity (GO:0002446)2.91676682
93myeloid dendritic cell activation (GO:0001773)2.91262223
94* antigen receptor-mediated signaling pathway (GO:0050851)2.87939538
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86719877
96regulation of alpha-beta T cell proliferation (GO:0046640)2.85779775
97positive regulation of isotype switching (GO:0045830)2.83484783
98neutrophil activation (GO:0042119)2.81667017
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76527964
100actin nucleation (GO:0045010)2.75593181
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73918147
102regulation of antigen processing and presentation (GO:0002577)2.73394881
103response to interferon-beta (GO:0035456)2.72607150
104T cell homeostasis (GO:0043029)2.71936968
105cellular response to interferon-beta (GO:0035458)2.71135980
106positive regulation of lamellipodium assembly (GO:0010592)2.70123558
107myeloid cell activation involved in immune response (GO:0002275)2.69595234
108positive regulation of macrophage differentiation (GO:0045651)2.69126625
109T cell selection (GO:0045058)2.67348927
110leukocyte cell-cell adhesion (GO:0007159)2.64712014
111lymphocyte homeostasis (GO:0002260)2.63733603
112response to muramyl dipeptide (GO:0032495)2.63704843
113negative regulation of B cell proliferation (GO:0030889)2.63287169
114positive regulation of mast cell activation (GO:0033005)2.63218940
115natural killer cell activation (GO:0030101)2.62625697
116macrophage activation involved in immune response (GO:0002281)2.60363584
117positive T cell selection (GO:0043368)2.60316087
118granulocyte activation (GO:0036230)2.59889335
119positive regulation of interferon-beta production (GO:0032728)2.59633703
120myeloid dendritic cell differentiation (GO:0043011)2.59598727
121positive regulation of B cell activation (GO:0050871)2.58529556
122regulation of necroptotic process (GO:0060544)2.57700529
123pinocytosis (GO:0006907)2.56848830
124positive regulation of interleukin-2 production (GO:0032743)2.56658889
125germinal center formation (GO:0002467)2.52952126
126* T cell costimulation (GO:0031295)2.51911365
127B cell proliferation (GO:0042100)2.51684444
128regulation of mast cell activation (GO:0033003)2.51566232
129mast cell degranulation (GO:0043303)2.50567431
130mast cell activation involved in immune response (GO:0002279)2.50567431
131positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50405987
132* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.49350527
133* lymphocyte costimulation (GO:0031294)2.48795720
134positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.48683700
135natural killer cell differentiation (GO:0001779)2.48433065
136* regulation of T cell receptor signaling pathway (GO:0050856)2.48224958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.89748072
2E2F7_22180533_ChIP-Seq_HELA_Human4.84005991
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.84738039
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.82605250
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72802067
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21514281
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14056388
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03496897
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96100051
10MYC_22102868_ChIP-Seq_BL_Human2.91954206
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65247917
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.62414197
13SCL_19346495_ChIP-Seq_HPC-7_Human2.61465458
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51491682
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.51447311
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45898560
17* VDR_21846776_ChIP-Seq_THP-1_Human2.44344642
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41809772
19* SPI1_23547873_ChIP-Seq_NB4_Human2.40110819
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39822759
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31214428
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28654233
23MYB_26560356_Chip-Seq_TH2_Human2.21639151
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18616809
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15569627
26* MAF_26560356_Chip-Seq_TH1_Human2.12267905
27* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09084620
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07114913
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05626638
30* MYB_26560356_Chip-Seq_TH1_Human2.01533939
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01121932
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00621502
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.97868805
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93419646
35* UTX_26944678_Chip-Seq_JUKART_Human1.86161246
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.85375365
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84164230
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82812302
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81744249
40* VDR_24763502_ChIP-Seq_THP-1_Human1.81171335
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78764785
42RUNX_20019798_ChIP-Seq_JUKART_Human1.78302801
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72256900
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68048119
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.67781109
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64051623
47TCF7_22412390_ChIP-Seq_EML_Mouse1.57631548
48SPI1_23127762_ChIP-Seq_K562_Human1.53702249
49VDR_24787735_ChIP-Seq_THP-1_Human1.50926233
50GATA1_22025678_ChIP-Seq_K562_Human1.49805921
51CIITA_25753668_ChIP-Seq_RAJI_Human1.48197232
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45473262
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43405164
54LXR_22292898_ChIP-Seq_THP-1_Human1.42131743
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41811219
56* MAF_26560356_Chip-Seq_TH2_Human1.40824544
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40105047
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37493453
59* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35962422
60VDR_23849224_ChIP-Seq_CD4+_Human1.35246668
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.31653530
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31279336
63FOXP3_21729870_ChIP-Seq_TREG_Human1.31182909
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30845697
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28747551
66GATA3_27048872_Chip-Seq_THYMUS_Human1.28697787
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27849180
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23213586
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20596439
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19093971
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17802114
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15738063
73BCOR_27268052_Chip-Seq_Bcells_Human1.15379422
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.15009636
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14874189
76PU_27001747_Chip-Seq_BMDM_Mouse1.14511998
77* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13646244
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.12131660
79* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11031058
80GATA1_19941826_ChIP-Seq_K562_Human1.10631586
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09652915
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07759559
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.07647650
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06467165
85* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05790995
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05563980
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04670713
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04568336
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04171842
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.03569788
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02076131
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.01942470
93* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99710919
94GATA3_26560356_Chip-Seq_TH2_Human0.99639775
95TFEB_21752829_ChIP-Seq_HELA_Human0.99032690
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97591109
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97311380
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97311247
99* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96687912
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96407720
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96081181
102* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95064860
103MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94675255
104* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93605423
105XRN2_22483619_ChIP-Seq_HELA_Human0.93391782
106* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92360092
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91755630
108SPI1_20517297_ChIP-Seq_HL60_Human0.91737718
109MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91583331
110KDM2B_26808549_Chip-Seq_DND41_Human0.90546534
111* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89278641
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.88643197
113ETS1_20019798_ChIP-Seq_JURKAT_Human0.88607652
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87926413
115* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85046149
116E2F1_21310950_ChIP-Seq_MCF-7_Human0.83785023
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83056441
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82979601
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82261321
120BCL6_27268052_Chip-Seq_Bcells_Human0.82044065
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.82020015
122NCOR1_26117541_ChIP-Seq_K562_Human0.81965690
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81461824
124P300_27268052_Chip-Seq_Bcells_Human0.81158983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.86384365
2MP0005671_abnormal_response_to3.51923567
3* MP0001800_abnormal_humoral_immune3.33600496
4MP0000685_abnormal_immune_system3.27848480
5MP0001790_abnormal_immune_system3.18208438
6MP0005387_immune_system_phenotype3.18208438
7MP0003436_decreased_susceptibility_to3.06111826
8* MP0005000_abnormal_immune_tolerance3.01275317
9* MP0009785_altered_susceptibility_to2.96549588
10* MP0002452_abnormal_antigen_presenting2.94568726
11MP0003763_abnormal_thymus_physiology2.81693280
12* MP0002723_abnormal_immune_serum2.77489257
13* MP0002420_abnormal_adaptive_immunity2.75093303
14* MP0005025_abnormal_response_to2.73088348
15* MP0001819_abnormal_immune_cell2.71757328
16MP0002396_abnormal_hematopoietic_system2.67867704
17MP0002148_abnormal_hypersensitivity_rea2.63379611
18MP0002419_abnormal_innate_immunity2.55431610
19* MP0002398_abnormal_bone_marrow2.51565327
20MP0006082_CNS_inflammation2.39901622
21* MP0000716_abnormal_immune_system2.31033670
22MP0003303_peritoneal_inflammation2.30361521
23* MP0000689_abnormal_spleen_morphology2.21243621
24MP0005464_abnormal_platelet_physiology2.17806622
25* MP0002405_respiratory_system_inflammati2.09501936
26* MP0002722_abnormal_immune_system2.06516147
27MP0009333_abnormal_splenocyte_physiolog2.02813984
28MP0002166_altered_tumor_susceptibility2.01613887
29* MP0002429_abnormal_blood_cell1.99051467
30MP0001853_heart_inflammation1.92367721
31MP0010155_abnormal_intestine_physiology1.87594714
32MP0001873_stomach_inflammation1.85051160
33MP0003724_increased_susceptibility_to1.84042971
34* MP0001845_abnormal_inflammatory_respons1.81319817
35MP0004808_abnormal_hematopoietic_stem1.72014566
36MP0004947_skin_inflammation1.67482146
37MP0002006_tumorigenesis1.65573814
38MP0000465_gastrointestinal_hemorrhage1.58305287
39* MP0000703_abnormal_thymus_morphology1.57252975
40MP0001545_abnormal_hematopoietic_system1.55824260
41MP0005397_hematopoietic_system_phenotyp1.55824260
42MP0008260_abnormal_autophagy1.52112585
43MP0005075_abnormal_melanosome_morpholog1.51886109
44MP0003172_abnormal_lysosome_physiology1.50676040
45MP0003183_abnormal_peptide_metabolism1.49395901
46MP0003300_gastrointestinal_ulcer1.49123686
47MP0000490_abnormal_crypts_of1.48214713
48MP0005058_abnormal_lysosome_morphology1.46349335
49MP0008057_abnormal_DNA_replication1.42677411
50MP0008469_abnormal_protein_level1.40808693
51MP0004510_myositis1.34771428
52MP0005451_abnormal_body_composition1.34607439
53MP0001533_abnormal_skeleton_physiology1.33827435
54MP0003693_abnormal_embryo_hatching1.33447299
55MP0005174_abnormal_tail_pigmentation1.33271121
56MP0000858_altered_metastatic_potential1.31769457
57MP0009278_abnormal_bone_marrow1.31714959
58MP0003866_abnormal_defecation1.30925023
59MP0003191_abnormal_cellular_cholesterol1.30167202
60MP0002138_abnormal_hepatobiliary_system1.27085696
61MP0002019_abnormal_tumor_incidence1.16230163
62MP0003448_altered_tumor_morphology1.11928662
63MP0000343_altered_response_to1.07635087
64MP0010094_abnormal_chromosome_stability1.04999501
65MP0002132_abnormal_respiratory_system1.01382344
66MP0009764_decreased_sensitivity_to1.00536335
67* MP0005310_abnormal_salivary_gland1.00431803
68MP0004883_abnormal_blood_vessel0.99654604
69MP0010352_gastrointestinal_tract_polyps0.98648303
70* MP0003077_abnormal_cell_cycle0.96973141
71MP0003806_abnormal_nucleotide_metabolis0.94323047
72MP0004957_abnormal_blastocyst_morpholog0.93346634
73* MP0002933_joint_inflammation0.91676806
74MP0000604_amyloidosis0.90921035
75MP0008007_abnormal_cellular_replicative0.90696190
76MP0000015_abnormal_ear_pigmentation0.89669960
77MP0010307_abnormal_tumor_latency0.86231518
78MP0009840_abnormal_foam_cell0.83665134
79MP0009763_increased_sensitivity_to0.82940302
80MP0003690_abnormal_glial_cell0.79811891
81MP0001851_eye_inflammation0.76682628
82* MP0000313_abnormal_cell_death0.75856222
83MP0003111_abnormal_nucleus_morphology0.74948695
84MP0002009_preneoplasia0.73263532
85MP0000371_diluted_coat_color0.72174464
86MP0002277_abnormal_respiratory_mucosa0.71199498
87MP0005164_abnormal_response_to0.70712261
88MP0003045_fibrosis0.70656871
89MP0008058_abnormal_DNA_repair0.69711848
90MP0002998_abnormal_bone_remodeling0.66509532
91MP0005023_abnormal_wound_healing0.66231048
92MP0003075_altered_response_to0.66194249
93MP0003828_pulmonary_edema0.65417043
94MP0003656_abnormal_erythrocyte_physiolo0.65055481
95MP0002254_reproductive_system_inflammat0.62863248
96MP0008004_abnormal_stomach_pH0.62595084
97MP0000249_abnormal_blood_vessel0.61453645
98MP0008874_decreased_physiological_sensi0.60812854
99MP0005166_decreased_susceptibility_to0.60766375
100MP0002136_abnormal_kidney_physiology0.58641689
101MP0005390_skeleton_phenotype0.58209104
102MP0001986_abnormal_taste_sensitivity0.57321593
103MP0004264_abnormal_extraembryonic_tissu0.56972797
104* MP0002095_abnormal_skin_pigmentation0.56604636
105MP0008873_increased_physiological_sensi0.55179567
106MP0009765_abnormal_xenobiotic_induced0.54615514
107MP0000598_abnormal_liver_morphology0.54482166
108MP0000609_abnormal_liver_physiology0.53842670
109MP0003795_abnormal_bone_structure0.53562609
110MP0001663_abnormal_digestive_system0.53285886
111MP0000477_abnormal_intestine_morphology0.53184124
112MP0000350_abnormal_cell_proliferation0.53009062
113MP0002693_abnormal_pancreas_physiology0.52895196
114MP0004381_abnormal_hair_follicle0.52652528
115MP0003091_abnormal_cell_migration0.51827022
116MP0005319_abnormal_enzyme/_coenzyme0.49690810
117MP0005381_digestive/alimentary_phenotyp0.44890310
118MP0005584_abnormal_enzyme/coenzyme_acti0.40013441
119MP0005076_abnormal_cell_differentiation0.39499847

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.47622811
2Eczematoid dermatitis (HP:0000976)5.01322657
3IgM deficiency (HP:0002850)4.85477031
4Recurrent bacterial skin infections (HP:0005406)4.83897466
5Elevated erythrocyte sedimentation rate (HP:0003565)4.57905344
6Agammaglobulinemia (HP:0004432)4.49405737
7Recurrent bronchitis (HP:0002837)4.41300258
8Recurrent viral infections (HP:0004429)4.18535180
9Myositis (HP:0100614)4.09772822
10Cellulitis (HP:0100658)4.05197458
11Recurrent fungal infections (HP:0002841)4.04496531
12Chronic otitis media (HP:0000389)4.03788332
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.82136968
14Meningitis (HP:0001287)3.73556527
15Gastrointestinal infarctions (HP:0005244)3.61736748
16Thrombocytosis (HP:0001894)3.59448324
17Recurrent skin infections (HP:0001581)3.58509710
18Mediastinal lymphadenopathy (HP:0100721)3.55690956
19Gastrointestinal stroma tumor (HP:0100723)3.54838308
20Inflammation of the large intestine (HP:0002037)3.53603902
21Gastrointestinal inflammation (HP:0004386)3.50588365
22Recurrent gram-negative bacterial infections (HP:0005420)3.49162117
23Vasculitis (HP:0002633)3.47420578
24Colitis (HP:0002583)3.46787031
25Panhypogammaglobulinemia (HP:0003139)3.46564968
26Chronic mucocutaneous candidiasis (HP:0002728)3.44521734
27Recurrent cutaneous fungal infections (HP:0011370)3.44521734
28Abnormality of T cell physiology (HP:0011840)3.42806294
29Lymphopenia (HP:0001888)3.39336576
30Nasal polyposis (HP:0100582)3.39333114
31Abnormality of T cells (HP:0002843)3.37567582
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.33101279
33Obstructive lung disease (HP:0006536)3.32585686
34Chronic obstructive pulmonary disease (HP:0006510)3.32585686
35Recurrent sinusitis (HP:0011108)3.31088299
36Petechiae (HP:0000967)3.15839040
37Abnormality of macrophages (HP:0004311)3.14799770
38T lymphocytopenia (HP:0005403)3.10992723
39Abnormality of T cell number (HP:0011839)3.08187741
40Abnormality of the nasal mucosa (HP:0000433)3.06024057
41Keratoconjunctivitis sicca (HP:0001097)3.00130612
42Orchitis (HP:0100796)2.99811606
43Combined immunodeficiency (HP:0005387)2.93346721
44Pustule (HP:0200039)2.90195342
45IgG deficiency (HP:0004315)2.88144685
46Thyroiditis (HP:0100646)2.87589282
47Spontaneous hematomas (HP:0007420)2.87383335
48Gingivitis (HP:0000230)2.79981664
49Keratoconjunctivitis (HP:0001096)2.77729231
50Stomatitis (HP:0010280)2.77209897
51Chronic diarrhea (HP:0002028)2.73521503
52Autoimmune thrombocytopenia (HP:0001973)2.70513452
53Vacuolated lymphocytes (HP:0001922)2.70288685
54Osteomyelitis (HP:0002754)2.68416090
55Interstitial pulmonary disease (HP:0006530)2.62057118
56Recurrent pneumonia (HP:0006532)2.61381796
57IgA deficiency (HP:0002720)2.59619744
58Prolonged bleeding time (HP:0003010)2.59411381
59Epistaxis (HP:0000421)2.58839484
60Pulmonary infiltrates (HP:0002113)2.57970037
61Recurrent lower respiratory tract infections (HP:0002783)2.56450519
62Leukocytosis (HP:0001974)2.56347775
63Emphysema (HP:0002097)2.52569797
64Lymphoma (HP:0002665)2.52139817
65Severe combined immunodeficiency (HP:0004430)2.51826557
66Chronic sinusitis (HP:0011109)2.48723634
67Encephalitis (HP:0002383)2.48340348
68Bronchitis (HP:0012387)2.47226632
69Retrobulbar optic neuritis (HP:0100654)2.45887461
70Optic neuritis (HP:0100653)2.45887461
71Chest pain (HP:0100749)2.44358763
72Increased cerebral lipofuscin (HP:0011813)2.43893671
73B lymphocytopenia (HP:0010976)2.43259762
74Abnormality of B cell number (HP:0010975)2.43259762
75Pulmonary embolism (HP:0002204)2.42849933
76Periodontitis (HP:0000704)2.39135922
77Papilloma (HP:0012740)2.37990155
78Verrucae (HP:0200043)2.37990155
79Purpura (HP:0000979)2.36803604
80Autoimmune hemolytic anemia (HP:0001890)2.36440546
81Increased IgE level (HP:0003212)2.35760253
82Restrictive lung disease (HP:0002091)2.34104952
83Impaired platelet aggregation (HP:0003540)2.31078042
84Abnormal platelet function (HP:0011869)2.31078042
85Abnormality of the prostate (HP:0008775)2.28020338
86Abnormality of the pleura (HP:0002103)2.27717198
87Abnormality of eosinophils (HP:0001879)2.27469581
88Urticaria (HP:0001025)2.26087324
89Sepsis (HP:0100806)2.25963700
90Hypergammaglobulinemia (HP:0010702)2.22552399
91Viral hepatitis (HP:0006562)2.22378853
92Eosinophilia (HP:0001880)2.22175779
93Episodic fever (HP:0001954)2.21523679
94Hypochromic microcytic anemia (HP:0004840)2.21281277
95Anorexia (HP:0002039)2.18920280
96Granulocytopenia (HP:0001913)2.18648414
97Hepatosplenomegaly (HP:0001433)2.18228123
98Skin ulcer (HP:0200042)2.18085839
99Arterial thrombosis (HP:0004420)2.17660094
100Gingival bleeding (HP:0000225)2.17135416
101Increased serum ferritin (HP:0003281)2.17119550
102Leukopenia (HP:0001882)2.16171863
103Systemic lupus erythematosus (HP:0002725)2.15153636
104Gangrene (HP:0100758)2.14435017
105Aplastic anemia (HP:0001915)2.12659470
106Increased neuronal autofluorescent lipopigment (HP:0002074)2.11202774
107Hemoptysis (HP:0002105)2.09343205
108Increased IgM level (HP:0003496)2.08113858
109Premature loss of primary teeth (HP:0006323)2.07731348
110Reduced antithrombin III activity (HP:0001976)2.04171548
111Agnosia (HP:0010524)2.03614863
112Hypochromic anemia (HP:0001931)2.03399121
113Skin rash (HP:0000988)2.03244865
114Dysostosis multiplex (HP:0000943)2.02865063
115Loss of speech (HP:0002371)2.02434187
116Arthralgia (HP:0002829)2.01043168
117Amyloidosis (HP:0011034)1.99505567
118Amaurosis fugax (HP:0100576)1.99423265
119Glomerulopathy (HP:0100820)1.98579751
120Abnormality of liposaccharide metabolism (HP:0010968)1.93921435
121Abnormality of glycosphingolipid metabolism (HP:0004343)1.93921435
122Abnormality of glycolipid metabolism (HP:0010969)1.93921435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.09453817
2BLK3.19666772
3ERN12.91983587
4CSF1R2.91686020
5PRPF4B2.84731981
6KIT2.62501028
7STK102.45835843
8TYK22.44979512
9GRK62.42571190
10BTK2.41242804
11IRAK42.38126093
12ZAP702.30003660
13TXK2.20780580
14MAP3K142.13071614
15TBK12.08451940
16SYK2.05215910
17TGFBR22.00037585
18TEC1.98912971
19JAK31.96791490
20RIPK41.80083642
21IKBKE1.75455724
22CDK121.65601406
23ITK1.63184587
24CSK1.62623876
25IKBKB1.57278818
26NME21.48845921
27MAP3K111.48159558
28HCK1.45389307
29LRRK21.41828713
30MAP3K101.41651824
31JAK11.41069606
32FLT31.39942606
33* LCK1.36775932
34EEF2K1.34048904
35MATK1.31560324
36MAP3K131.31341500
37KDR1.30349749
38TAOK11.29286194
39* LYN1.29091067
40IRAK31.27873775
41MAP3K31.26195903
42TESK21.24513334
43MAP2K31.23561520
44FES1.23203976
45SMG11.22267798
46CLK11.18721107
47BMPR21.12157137
48MAP3K11.07553810
49PIM21.02153974
50PIM11.00655503
51TAOK21.00462316
52ACVR1B0.98845314
53RPS6KA40.96633303
54TAOK30.93495721
55CHUK0.91571485
56NEK20.89118788
57FGFR40.84772127
58PKN20.82655331
59FGFR30.81874633
60TNK20.76577781
61TGFBR10.76083127
62MAPK120.74438357
63MST40.73978691
64NLK0.73841261
65GRK10.73171385
66ADRBK20.72821722
67MARK20.72109247
68KSR20.70022767
69STK40.69139791
70MAP2K60.68193545
71CDC42BPA0.67949387
72CDK190.67294091
73PDPK10.65462225
74SIK20.64624294
75YES10.64208531
76PRKD20.63328991
77JAK20.63076556
78IRAK10.61019770
79CDK40.60641181
80GRK70.58485801
81MARK30.58229287
82EIF2AK30.57693329
83HIPK20.57340315
84PAK40.56891853
85MAP3K80.56071868
86EPHB10.56001876
87* FYN0.54550287
88EIF2AK10.52331404
89IRAK20.51647251
90RPS6KB20.51082020
91MAP3K50.47124624
92CDK70.46758150
93PRKCD0.46743114
94MAPK40.46412249
95TRIB30.46147846
96MAPKAPK20.46113971
97RPS6KL10.45818794
98RPS6KC10.45818794
99MOS0.44839906
100PTK60.44773119
101NEK90.43866961
102PIK3CG0.43776358
103MAP3K70.42637498
104SIK10.42533394
105SIK30.40912077
106ATR0.40774391
107CAMKK10.40739988
108PRKG20.38921965
109MAPK110.36670282
110MAPK70.36407514
111MAP2K20.36118777
112CDC70.35951976
113SCYL20.34781991
114PDK10.34493486
115FGR0.34343148
116CAMKK20.34312069
117EIF2AK20.33603857
118BUB10.33130458
119* ABL10.31614689
120CDK60.31371624
121PASK0.31299238
122WEE10.31269283
123RAF10.31173064
124RPS6KA60.29323339
125PRKCH0.29113556
126* PRKCQ0.28656434
127TRPM70.28320663
128DYRK30.28250703
129ALK0.27956740
130STK110.27021192
131EGFR0.26014382
132IGF1R0.25229101
133CDK90.24823218

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.12032619
2* B cell receptor signaling pathway_Homo sapiens_hsa046622.80949541
3Antigen processing and presentation_Homo sapiens_hsa046122.57654403
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.54742093
5* Leishmaniasis_Homo sapiens_hsa051402.48936393
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.33506689
7DNA replication_Homo sapiens_hsa030302.33310886
8Measles_Homo sapiens_hsa051622.17257098
9Hematopoietic cell lineage_Homo sapiens_hsa046402.15072931
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10621885
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09397416
12Osteoclast differentiation_Homo sapiens_hsa043802.06070873
13* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94592556
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90440108
15Staphylococcus aureus infection_Homo sapiens_hsa051501.82262542
16Ribosome_Homo sapiens_hsa030101.80172051
17Herpes simplex infection_Homo sapiens_hsa051681.79666685
18Base excision repair_Homo sapiens_hsa034101.78616940
19Mismatch repair_Homo sapiens_hsa034301.76596635
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73293661
21Other glycan degradation_Homo sapiens_hsa005111.70892449
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69291684
23Legionellosis_Homo sapiens_hsa051341.64579709
24Graft-versus-host disease_Homo sapiens_hsa053321.61482731
25* T cell receptor signaling pathway_Homo sapiens_hsa046601.53315504
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.53294594
27Allograft rejection_Homo sapiens_hsa053301.50659796
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45374980
29Pertussis_Homo sapiens_hsa051331.44447551
30Tuberculosis_Homo sapiens_hsa051521.41287882
31Influenza A_Homo sapiens_hsa051641.38351454
32* Jak-STAT signaling pathway_Homo sapiens_hsa046301.37803742
33Shigellosis_Homo sapiens_hsa051311.37001751
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36782396
35Apoptosis_Homo sapiens_hsa042101.30286399
36Toxoplasmosis_Homo sapiens_hsa051451.26846752
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24635911
38Homologous recombination_Homo sapiens_hsa034401.23653559
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23210964
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.22411782
41Acute myeloid leukemia_Homo sapiens_hsa052211.17174359
42Chemokine signaling pathway_Homo sapiens_hsa040621.16182981
43Malaria_Homo sapiens_hsa051441.15209921
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08831810
45Hepatitis B_Homo sapiens_hsa051611.08181624
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04569903
47Lysosome_Homo sapiens_hsa041421.02548354
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00483453
49Viral myocarditis_Homo sapiens_hsa054161.00350599
50Asthma_Homo sapiens_hsa053100.99893106
51Spliceosome_Homo sapiens_hsa030400.99669331
52Epstein-Barr virus infection_Homo sapiens_hsa051690.98960879
53Salmonella infection_Homo sapiens_hsa051320.98300983
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95819346
55Non-homologous end-joining_Homo sapiens_hsa034500.95032255
56TNF signaling pathway_Homo sapiens_hsa046680.92255059
57Platelet activation_Homo sapiens_hsa046110.90854771
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90101328
59Nucleotide excision repair_Homo sapiens_hsa034200.82462900
60Pancreatic cancer_Homo sapiens_hsa052120.76923374
61Pentose phosphate pathway_Homo sapiens_hsa000300.76666814
62Viral carcinogenesis_Homo sapiens_hsa052030.75646997
63p53 signaling pathway_Homo sapiens_hsa041150.75181674
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73452461
65Pyrimidine metabolism_Homo sapiens_hsa002400.70878310
66HTLV-I infection_Homo sapiens_hsa051660.70869180
67Hepatitis C_Homo sapiens_hsa051600.70697178
68Chronic myeloid leukemia_Homo sapiens_hsa052200.69743909
69Fanconi anemia pathway_Homo sapiens_hsa034600.69310707
70African trypanosomiasis_Homo sapiens_hsa051430.68409396
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67182945
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66392023
73Caffeine metabolism_Homo sapiens_hsa002320.64686195
74Proteasome_Homo sapiens_hsa030500.62718287
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60379490
76Autoimmune thyroid disease_Homo sapiens_hsa053200.58676296
77Cell cycle_Homo sapiens_hsa041100.58490728
78Non-small cell lung cancer_Homo sapiens_hsa052230.55334324
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.54249335
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53569867
81RNA polymerase_Homo sapiens_hsa030200.53327385
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.53029873
83RNA degradation_Homo sapiens_hsa030180.53010204
84Endocytosis_Homo sapiens_hsa041440.52658581
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50704614
86Type I diabetes mellitus_Homo sapiens_hsa049400.49309279
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49051472
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48100243
89VEGF signaling pathway_Homo sapiens_hsa043700.47565366
90RNA transport_Homo sapiens_hsa030130.45234974
91Renal cell carcinoma_Homo sapiens_hsa052110.45092567
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.44814320
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43362646
94One carbon pool by folate_Homo sapiens_hsa006700.42357634
95Phagosome_Homo sapiens_hsa041450.41072175
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40908629
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.40899512
98Galactose metabolism_Homo sapiens_hsa000520.40494969
99Rheumatoid arthritis_Homo sapiens_hsa053230.39665897
100Systemic lupus erythematosus_Homo sapiens_hsa053220.38741591
101Colorectal cancer_Homo sapiens_hsa052100.36873598
102Notch signaling pathway_Homo sapiens_hsa043300.36489440
103N-Glycan biosynthesis_Homo sapiens_hsa005100.35853043
104HIF-1 signaling pathway_Homo sapiens_hsa040660.34530855
105Small cell lung cancer_Homo sapiens_hsa052220.33930359
106GnRH signaling pathway_Homo sapiens_hsa049120.33232807
107Choline metabolism in cancer_Homo sapiens_hsa052310.33138781
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32587395
109Prolactin signaling pathway_Homo sapiens_hsa049170.31612823
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30985769
111FoxO signaling pathway_Homo sapiens_hsa040680.30896762
112MAPK signaling pathway_Homo sapiens_hsa040100.30880848
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30327603
114Inositol phosphate metabolism_Homo sapiens_hsa005620.30064018
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29347028
116mTOR signaling pathway_Homo sapiens_hsa041500.28653961
117Insulin resistance_Homo sapiens_hsa049310.28457665
118Fructose and mannose metabolism_Homo sapiens_hsa000510.28246974
119Amoebiasis_Homo sapiens_hsa051460.27355721
120Endometrial cancer_Homo sapiens_hsa052130.27074281
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.26392236
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25346417
123Dorso-ventral axis formation_Homo sapiens_hsa043200.19937373
124Type II diabetes mellitus_Homo sapiens_hsa049300.19871599
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17306042
126Bladder cancer_Homo sapiens_hsa052190.17063372
127Prostate cancer_Homo sapiens_hsa052150.15797992
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14258790

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