PTPN9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fatty acid transport (GO:2000192)4.25124936
2lens fiber cell development (GO:0070307)4.11124047
3COPI coating of Golgi vesicle (GO:0048205)4.03059590
4Golgi transport vesicle coating (GO:0048200)4.03059590
5lung-associated mesenchyme development (GO:0060484)4.02365619
6dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.97494355
7cell adhesion mediated by integrin (GO:0033627)3.96523186
8chondrocyte proliferation (GO:0035988)3.88122848
9respiratory tube development (GO:0030323)3.82530609
10axon extension involved in axon guidance (GO:0048846)3.81840349
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.81840349
12apoptotic process involved in morphogenesis (GO:0060561)3.68170041
13collagen fibril organization (GO:0030199)3.65743029
14paraxial mesoderm development (GO:0048339)3.63394944
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48605940
16regulation of NFAT protein import into nucleus (GO:0051532)3.44045355
17anatomical structure regression (GO:0060033)3.36681238
18endodermal cell differentiation (GO:0035987)3.36331973
19growth hormone receptor signaling pathway (GO:0060396)3.33184333
20protein heterotrimerization (GO:0070208)3.31402521
21mesenchymal-epithelial cell signaling (GO:0060638)3.27401875
22hippo signaling (GO:0035329)3.27044970
23metanephric nephron tubule development (GO:0072234)3.25117125
24metanephric tubule development (GO:0072170)3.25117125
25barbed-end actin filament capping (GO:0051016)3.21596381
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.19338016
27apoptotic cell clearance (GO:0043277)3.18502740
28embryonic body morphogenesis (GO:0010172)3.15990890
29metanephric nephron epithelium development (GO:0072243)3.13452721
30heterochromatin organization (GO:0070828)3.13040748
31negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.09480185
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.06546634
33sequestering of extracellular ligand from receptor (GO:0035581)3.05889852
34semaphorin-plexin signaling pathway (GO:0071526)3.02204231
35establishment of planar polarity (GO:0001736)2.99722513
36establishment of tissue polarity (GO:0007164)2.99722513
37positive regulation of glycogen biosynthetic process (GO:0045725)2.99093684
38apoptotic process involved in development (GO:1902742)2.98579920
39stress fiber assembly (GO:0043149)2.95951775
40cellular response to growth hormone stimulus (GO:0071378)2.95093146
41virion attachment to host cell (GO:0019062)2.94935471
42adhesion of symbiont to host cell (GO:0044650)2.94935471
43negative regulation of fibroblast apoptotic process (GO:2000270)2.94918218
44cellular response to vitamin D (GO:0071305)2.93238224
45metanephric epithelium development (GO:0072207)2.90286986
46kidney morphogenesis (GO:0060993)2.88405903
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88177503
48adhesion of symbiont to host (GO:0044406)2.87007329
49glucocorticoid receptor signaling pathway (GO:0042921)2.84746605
50camera-type eye morphogenesis (GO:0048593)2.83965831
51body morphogenesis (GO:0010171)2.81484057
52positive regulation of endothelial cell apoptotic process (GO:2000353)2.80735669
53cellular response to vitamin (GO:0071295)2.80703059
54eye morphogenesis (GO:0048592)2.80396776
55regulation of fatty acid beta-oxidation (GO:0031998)2.80196814
56positive regulation of nitric-oxide synthase activity (GO:0051000)2.80170360
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.79811894
58hemidesmosome assembly (GO:0031581)2.78811297
59nuclear pore complex assembly (GO:0051292)2.77783217
60convergent extension (GO:0060026)2.77085230
61glial cell proliferation (GO:0014009)2.76498000
62midgut development (GO:0007494)2.75823158
63cell-cell junction maintenance (GO:0045217)2.74554376
64regulation of tight junction assembly (GO:2000810)2.74190985
65regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.74043291
66collecting duct development (GO:0072044)2.73802370
67cell-substrate junction assembly (GO:0007044)2.73500540
68negative regulation of catenin import into nucleus (GO:0035414)2.73199306
69embryonic foregut morphogenesis (GO:0048617)2.72979923
70craniofacial suture morphogenesis (GO:0097094)2.72218399
71plasma membrane repair (GO:0001778)2.70766112
72endocardial cushion development (GO:0003197)2.69497738
73activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68995029
74outer ear morphogenesis (GO:0042473)2.68393069
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68345792
76protein retention in ER lumen (GO:0006621)2.66546922
77cell migration involved in sprouting angiogenesis (GO:0002042)2.65754508
78cellular response to prostaglandin stimulus (GO:0071379)2.65029845
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64502508
80regulation of early endosome to late endosome transport (GO:2000641)2.63996486
81histone H3-K36 demethylation (GO:0070544)2.63584587
82G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.62713436
83skin morphogenesis (GO:0043589)2.62345589
84chondroitin sulfate biosynthetic process (GO:0030206)2.58777247
85regulation of RNA export from nucleus (GO:0046831)2.57281437
86positive regulation of fatty acid beta-oxidation (GO:0032000)2.55890478
87cartilage morphogenesis (GO:0060536)2.54954406
88corticosteroid receptor signaling pathway (GO:0031958)2.54904911
89positive regulation of nuclease activity (GO:0032075)2.54403799
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54402570
91planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54112466
92Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54019733
93collagen metabolic process (GO:0032963)2.53997867
94cell-substrate adherens junction assembly (GO:0007045)2.53453956
95focal adhesion assembly (GO:0048041)2.53453956
96gastrulation with mouth forming second (GO:0001702)2.53405282
97positive regulation of epithelial to mesenchymal transition (GO:0010718)2.52724039
98axonal fasciculation (GO:0007413)2.52709241
99hypotonic response (GO:0006971)2.51869110
100vascular endothelial growth factor signaling pathway (GO:0038084)2.51412076
101negative regulation of sodium ion transport (GO:0010766)2.51231485
102protein localization to cell surface (GO:0034394)2.50067333
103bone trabecula formation (GO:0060346)2.48936924
104regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.48190413
105negative regulation of lipid transport (GO:0032369)2.47844943
106chondrocyte development (GO:0002063)2.46360747
107collagen catabolic process (GO:0030574)2.46302998
108extracellular matrix disassembly (GO:0022617)2.46166035
109adherens junction assembly (GO:0034333)2.45931614
110positive regulation of glycogen metabolic process (GO:0070875)2.45489389
111heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.45430423
112polarized epithelial cell differentiation (GO:0030859)2.45219287
113basement membrane organization (GO:0071711)2.45035336
114regulation of nucleobase-containing compound transport (GO:0032239)2.44349665
115protein localization to endosome (GO:0036010)2.43616148
116positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43143152
117actin filament bundle organization (GO:0061572)2.43118963
118actin filament bundle assembly (GO:0051017)2.43118963
119neuron projection extension (GO:1990138)2.42320573
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.42160031
121neural tube development (GO:0021915)2.42141215
122multicellular organismal macromolecule metabolic process (GO:0044259)2.41726442
123establishment of nucleus localization (GO:0040023)2.41714387
124mannose metabolic process (GO:0006013)2.41496409
125retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41403795
126metanephric mesenchyme development (GO:0072075)2.41227519
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41103636
128negative regulation of cell size (GO:0045792)2.41005288
129endoplasmic reticulum unfolded protein response (GO:0030968)2.40809915
130lung epithelium development (GO:0060428)2.40508033
131dorsal/ventral axis specification (GO:0009950)2.39286284
132substrate adhesion-dependent cell spreading (GO:0034446)2.38243501
133vesicle coating (GO:0006901)2.37755704
134endothelial cell morphogenesis (GO:0001886)2.37307978
135cellular protein complex localization (GO:0034629)2.37272301
136glial cell migration (GO:0008347)2.36924501
137positive regulation of histone deacetylation (GO:0031065)2.36881310
138positive regulation of macrophage activation (GO:0043032)2.36610722
139regulation of apoptotic process involved in morphogenesis (GO:1902337)2.36307666
140endothelial cell chemotaxis (GO:0035767)2.36208269
141protein hydroxylation (GO:0018126)2.36138536
142Notch signaling involved in heart development (GO:0061314)2.36071219
143negative regulation of chondrocyte differentiation (GO:0032331)2.36005429
144regulation of establishment of planar polarity (GO:0090175)2.35993138
145cortical actin cytoskeleton organization (GO:0030866)2.33635586
146regulation of membrane protein ectodomain proteolysis (GO:0051043)2.32814792
147protein complex localization (GO:0031503)2.32767904
148substrate-dependent cell migration (GO:0006929)2.32636791
149cochlea morphogenesis (GO:0090103)2.32626220
150kidney mesenchyme development (GO:0072074)2.32311296
151receptor catabolic process (GO:0032801)2.32202697
152multicellular organismal metabolic process (GO:0044236)2.31645952
153germ cell migration (GO:0008354)2.31069851
154organ induction (GO:0001759)2.30492421
155heparan sulfate proteoglycan metabolic process (GO:0030201)2.29906444
156cellular response to unfolded protein (GO:0034620)2.29610388
157regulation of polysaccharide biosynthetic process (GO:0032885)2.29382920
158epithelial cell-cell adhesion (GO:0090136)2.28534864
159multicellular organismal catabolic process (GO:0044243)2.27855902
160response to fluid shear stress (GO:0034405)2.27459568
161positive regulation of axon extension (GO:0045773)2.26992971
162blood vessel endothelial cell migration (GO:0043534)2.26781392
163mesodermal cell differentiation (GO:0048333)2.26739545
164axon extension (GO:0048675)2.26549217
165negative regulation of heart growth (GO:0061117)2.25882713
166negative regulation of cardiac muscle tissue growth (GO:0055022)2.25882713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.04351258
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.98728341
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.91132204
4E2F7_22180533_ChIP-Seq_HELA_Human3.82874443
5CLOCK_20551151_ChIP-Seq_293T_Human3.30800001
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.29596448
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.86063428
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35193510
9* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29765967
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29563128
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08497219
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04572701
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96222813
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94769330
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84767354
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83410472
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82371000
18DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.82076451
19P300_27058665_Chip-Seq_ZR-75-30cells_Human1.76955785
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74554373
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70793492
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.68868280
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68433689
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67875805
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66525224
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.66334139
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65636929
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63695780
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.62200346
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60740246
31* BRD4_25478319_ChIP-Seq_HGPS_Human1.60739020
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.58911554
33KDM2B_26808549_Chip-Seq_DND41_Human1.55825869
34TP53_22127205_ChIP-Seq_IMR90_Human1.54069986
35KDM2B_26808549_Chip-Seq_K562_Human1.50877655
36AR_21909140_ChIP-Seq_LNCAP_Human1.50732530
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50244284
38CJUN_26792858_Chip-Seq_BT549_Human1.50085297
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49213959
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48762599
41TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48557564
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.47844378
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47585493
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45966604
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.40448027
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40177366
47* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39467860
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.39242547
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37591811
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37407972
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37255965
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35240652
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34844191
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.34209042
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.33514844
56VDR_21846776_ChIP-Seq_THP-1_Human1.33268995
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32724340
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.32468539
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31492774
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.31153353
61* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29201766
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.26765403
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.26293494
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25784283
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25611572
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25498633
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25407779
68RACK7_27058665_Chip-Seq_MCF-7_Human1.24389159
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23472970
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23472970
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22628065
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21868908
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21443594
74LXR_22292898_ChIP-Seq_THP-1_Human1.19887888
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19836835
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19452240
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19452240
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.18969892
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.18518540
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17353496
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.17139348
82ATF3_27146783_Chip-Seq_COLON_Human1.17048665
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16811418
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16811418
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.16704044
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15670898
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15587267
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14939385
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14345741
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.13492583
91* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11727397
92SOX2_20726797_ChIP-Seq_SW620_Human1.11562084
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11132113
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11014002
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10814935
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10200415
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09433472
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09220091
99MYC_22102868_ChIP-Seq_BL_Human1.09112356
100TP53_16413492_ChIP-PET_HCT116_Human1.07055454
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06288503
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05888359
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05686503
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.04995952
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.04995952
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04181190
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.03773852
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03588372
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02487447
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02470282
111TP53_23651856_ChIP-Seq_MEFs_Mouse1.02266739
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.01208966
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01126265
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00813524
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00812360
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00307359
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99812419
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99704396
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99426580
120POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98684108
121ZNF263_19887448_ChIP-Seq_K562_Human0.98511206
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98423498
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98421669
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.98095283
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97991953
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97202649
127SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96995195
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96962034
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96929608
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.96824169
131TP53_18474530_ChIP-ChIP_U2OS_Human0.96374882
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.96329787
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96217499
134* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95560927
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91218777
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90969313
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90464437
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.89555166
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88508539
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.88185086
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87632607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.99930426
2MP0003705_abnormal_hypodermis_morpholog4.55166515
3MP0003300_gastrointestinal_ulcer3.11972167
4MP0005503_abnormal_tendon_morphology3.05100396
5MP0005275_abnormal_skin_tensile2.97674168
6MP0003279_aneurysm2.90001178
7MP0009384_cardiac_valve_regurgitation2.89452040
8MP0005409_darkened_coat_color2.75107079
9MP0001958_emphysema2.59866922
10MP0004272_abnormal_basement_membrane2.58139653
11MP0006054_spinal_hemorrhage2.49649419
12MP0010352_gastrointestinal_tract_polyps2.46243670
13MP0005623_abnormal_meninges_morphology2.41674028
14MP0000569_abnormal_digit_pigmentation2.39269002
15MP0009840_abnormal_foam_cell2.20945067
16MP0002877_abnormal_melanocyte_morpholog2.17416501
17MP0004858_abnormal_nervous_system2.17156664
18MP0009053_abnormal_anal_canal2.04092242
19MP0000537_abnormal_urethra_morphology1.96281493
20MP0003566_abnormal_cell_adhesion1.95236682
21MP0009780_abnormal_chondrocyte_physiolo1.94370652
22MP0010368_abnormal_lymphatic_system1.91420092
23MP0010234_abnormal_vibrissa_follicle1.80827723
24MP0003942_abnormal_urinary_system1.80251481
25MP0000534_abnormal_ureter_morphology1.79310913
26MP0003091_abnormal_cell_migration1.76746291
27MP0001299_abnormal_eye_distance/1.74594143
28MP0005076_abnormal_cell_differentiation1.74506162
29MP0000015_abnormal_ear_pigmentation1.71368862
30MP0002896_abnormal_bone_mineralization1.69959448
31MP0000733_abnormal_muscle_development1.68248875
32MP0010030_abnormal_orbit_morphology1.67555372
33MP0003303_peritoneal_inflammation1.57494115
34MP0003115_abnormal_respiratory_system1.54746799
35MP0005508_abnormal_skeleton_morphology1.54480473
36MP0001348_abnormal_lacrimal_gland1.54102435
37MP0005248_abnormal_Harderian_gland1.53747199
38MP0002092_abnormal_eye_morphology1.49656426
39MP0001849_ear_inflammation1.45732503
40MP0003385_abnormal_body_wall1.44967534
41MP0005023_abnormal_wound_healing1.39938148
42MP0003045_fibrosis1.39895642
43MP0005257_abnormal_intraocular_pressure1.39774798
44MP0002282_abnormal_trachea_morphology1.39003054
45MP0000767_abnormal_smooth_muscle1.35132851
46MP0009250_abnormal_appendicular_skeleto1.33283453
47MP0000013_abnormal_adipose_tissue1.32640270
48MP0000516_abnormal_urinary_system1.30996084
49MP0005367_renal/urinary_system_phenotyp1.30996084
50MP0005058_abnormal_lysosome_morphology1.28230733
51MP0000428_abnormal_craniofacial_morphol1.23549342
52MP0003122_maternal_imprinting1.23277467
53MP0008057_abnormal_DNA_replication1.22593042
54MP0000462_abnormal_digestive_system1.18388625
55MP0008961_abnormal_basal_metabolism1.18261107
56MP0003283_abnormal_digestive_organ1.16410187
57* MP0002115_abnormal_skeleton_extremities1.10570328
58MP0002932_abnormal_joint_morphology1.09599002
59MP0002089_abnormal_postnatal_growth/wei1.08307175
60MP0002168_other_aberrant_phenotype1.07732557
61MP0005187_abnormal_penis_morphology1.07380905
62MP0003252_abnormal_bile_duct1.07364409
63MP0000163_abnormal_cartilage_morphology1.06662686
64MP0003172_abnormal_lysosome_physiology1.06086849
65MP0009379_abnormal_foot_pigmentation1.06001145
66MP0001879_abnormal_lymphatic_vessel1.05757793
67MP0002009_preneoplasia1.02205419
68MP0002113_abnormal_skeleton_development1.00654018
69MP0003453_abnormal_keratinocyte_physiol0.99706205
70MP0002295_abnormal_pulmonary_circulatio0.97147984
71MP0002084_abnormal_developmental_patter0.96412559
72MP0000003_abnormal_adipose_tissue0.94870370
73MP0001270_distended_abdomen0.93403884
74* MP0002085_abnormal_embryonic_tissue0.92644024
75MP0003935_abnormal_craniofacial_develop0.92452356
76MP0002909_abnormal_adrenal_gland0.92024061
77MP0000778_abnormal_nervous_system0.90993287
78MP0000538_abnormal_urinary_bladder0.90397360
79MP0005390_skeleton_phenotype0.89643516
80MP0001730_embryonic_growth_arrest0.89121289
81MP0000350_abnormal_cell_proliferation0.88547401
82MP0000762_abnormal_tongue_morphology0.88042429
83MP0005220_abnormal_exocrine_pancreas0.86332433
84MP0010307_abnormal_tumor_latency0.86049125
85MP0003634_abnormal_glial_cell0.85775918
86MP0002060_abnormal_skin_morphology0.85617020
87MP0005174_abnormal_tail_pigmentation0.85165984
88MP0002998_abnormal_bone_remodeling0.84588893
89MP0002086_abnormal_extraembryonic_tissu0.84314277
90MP0005197_abnormal_uvea_morphology0.84299292
91MP0001188_hyperpigmentation0.83312636
92MP0000049_abnormal_middle_ear0.82774659
93MP0003693_abnormal_embryo_hatching0.82337139
94MP0003890_abnormal_embryonic-extraembry0.81707808
95MP0002925_abnormal_cardiovascular_devel0.81601004
96MP0005595_abnormal_vascular_smooth0.81238991
97* MP0002128_abnormal_blood_circulation0.80328491
98MP0002109_abnormal_limb_morphology0.80189216
99MP0002396_abnormal_hematopoietic_system0.78882719
100MP0010386_abnormal_urinary_bladder0.78131654
101MP0002108_abnormal_muscle_morphology0.77865877
102* MP0002114_abnormal_axial_skeleton0.77787204
103MP0002254_reproductive_system_inflammat0.77415346
104MP0001533_abnormal_skeleton_physiology0.76839779
105MP0002111_abnormal_tail_morphology0.76139004
106MP0005193_abnormal_anterior_eye0.75487387
107MP0000490_abnormal_crypts_of0.75484815
108MP0003795_abnormal_bone_structure0.75223450
109MP0001614_abnormal_blood_vessel0.74057329
110* MP0003861_abnormal_nervous_system0.72559328
111MP0002928_abnormal_bile_duct0.72104267
112MP0005621_abnormal_cell_physiology0.71610201
113MP0003941_abnormal_skin_development0.71513641
114* MP0005380_embryogenesis_phenotype0.71097289
115* MP0001672_abnormal_embryogenesis/_devel0.71097289
116MP0003755_abnormal_palate_morphology0.70455294
117MP0004130_abnormal_muscle_cell0.70296640
118MP0004197_abnormal_fetal_growth/weight/0.69727668
119* MP0003984_embryonic_growth_retardation0.69613464
120MP0005381_digestive/alimentary_phenotyp0.68091474
121MP0004808_abnormal_hematopoietic_stem0.67806352
122* MP0002116_abnormal_craniofacial_bone0.67036976
123* MP0000432_abnormal_head_morphology0.64357712
124MP0002933_joint_inflammation0.63158596
125MP0004883_abnormal_blood_vessel0.62774894
126MP0001175_abnormal_lung_morphology0.62756364
127MP0002697_abnormal_eye_size0.61810410
128MP0003329_amyloid_beta_deposits0.60915512
129MP0009278_abnormal_bone_marrow0.60462988
130* MP0001915_intracranial_hemorrhage0.60112016
131MP0000858_altered_metastatic_potential0.58470909
132MP0003123_paternal_imprinting0.58237729
133MP0001177_atelectasis0.58113812
134MP0009672_abnormal_birth_weight0.57446771
135MP0002233_abnormal_nose_morphology0.56893302
136MP0003448_altered_tumor_morphology0.56880017
137MP0002177_abnormal_outer_ear0.56829506
138MP0001881_abnormal_mammary_gland0.56531701
139MP0001346_abnormal_lacrimal_gland0.55801493

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.42022087
2Premature rupture of membranes (HP:0001788)4.38812670
3Shallow orbits (HP:0000586)3.97724210
4Cerebral aneurysm (HP:0004944)3.53551222
5Aortic aneurysm (HP:0004942)3.45287506
6Broad metatarsal (HP:0001783)3.34852616
7Cervical subluxation (HP:0003308)3.26176254
8Ankle contracture (HP:0006466)3.25545163
9Aortic dissection (HP:0002647)3.21458340
10Dilatation of the ascending aorta (HP:0005111)3.13863814
11Bladder diverticulum (HP:0000015)3.08995419
12Peritonitis (HP:0002586)3.04419708
13Asymmetry of the thorax (HP:0001555)2.96319171
14Mitral valve prolapse (HP:0001634)2.91561049
15Atrophic scars (HP:0001075)2.76761452
16Deviation of the hallux (HP:0010051)2.73432960
17Subacute progressive viral hepatitis (HP:0006572)2.69775365
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69661922
19Short 4th metacarpal (HP:0010044)2.69661922
20Bowel diverticulosis (HP:0005222)2.65200752
21Buphthalmos (HP:0000557)2.61399062
22Hallux valgus (HP:0001822)2.60108989
23Arnold-Chiari malformation (HP:0002308)2.58682439
24Hyperacusis (HP:0010780)2.58463587
25Enlarged penis (HP:0000040)2.57233051
26Genu recurvatum (HP:0002816)2.51594698
27Aneurysm (HP:0002617)2.49600628
28Long toe (HP:0010511)2.47975113
29Overriding aorta (HP:0002623)2.45606871
30Absent frontal sinuses (HP:0002688)2.45352724
31Increased density of long bones (HP:0006392)2.42872779
32Vascular tortuosity (HP:0004948)2.41166156
33Abnormality of the 4th metacarpal (HP:0010012)2.37916731
34Insomnia (HP:0100785)2.35797068
35Overgrowth (HP:0001548)2.33879142
36Thin bony cortex (HP:0002753)2.33350766
37Camptodactyly of toe (HP:0001836)2.32128815
38Arterial tortuosity (HP:0005116)2.31521866
39Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.31458775
40Soft skin (HP:0000977)2.29503817
41Wrist flexion contracture (HP:0001239)2.28228242
42Abnormality of dentin (HP:0010299)2.25722189
43Lymphangioma (HP:0100764)2.25230224
44Blue sclerae (HP:0000592)2.24965152
45Fragile skin (HP:0001030)2.23006451
46Wormian bones (HP:0002645)2.22238931
47Renal duplication (HP:0000075)2.21847524
48Striae distensae (HP:0001065)2.19902150
49Mitral regurgitation (HP:0001653)2.19542286
50Turricephaly (HP:0000262)2.19273017
51Macroorchidism (HP:0000053)2.15234605
52Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.11605131
53Long palpebral fissure (HP:0000637)2.08643812
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.08381072
55Osteolytic defects of the hand bones (HP:0009699)2.08381072
56Exostoses (HP:0100777)2.07977137
57Radial bowing (HP:0002986)2.06754669
58Syringomyelia (HP:0003396)2.05277780
59Spinal cord lesions (HP:0100561)2.05277780
60Trigonocephaly (HP:0000243)2.04868497
61Flat cornea (HP:0007720)2.04430146
62Hyperextensible skin (HP:0000974)2.04170446
63Wide anterior fontanel (HP:0000260)2.01249096
64Rectal prolapse (HP:0002035)1.97969951
65Persistence of primary teeth (HP:0006335)1.97047948
66Back pain (HP:0003418)1.95351814
67Vertebral arch anomaly (HP:0008438)1.93441530
68Vertebral compression fractures (HP:0002953)1.93330599
69Coronal craniosynostosis (HP:0004440)1.93324096
70Ectopia lentis (HP:0001083)1.92955204
71Broad ribs (HP:0000885)1.91087770
72Neonatal short-limb short stature (HP:0008921)1.90423019
73Long eyelashes (HP:0000527)1.89068856
74Disproportionate tall stature (HP:0001519)1.87682119
75Congenital glaucoma (HP:0001087)1.87314760
76High anterior hairline (HP:0009890)1.87068654
77Renovascular hypertension (HP:0100817)1.85477454
78Ulnar bowing (HP:0003031)1.85017695
79Follicular hyperkeratosis (HP:0007502)1.84454875
80Abnormality of the thoracic spine (HP:0100711)1.84308431
81Deep venous thrombosis (HP:0002625)1.84045881
82Abnormality of the acetabulum (HP:0003170)1.83501337
83Biconcave vertebral bodies (HP:0004586)1.82958736
84Joint laxity (HP:0001388)1.81122839
85Flat acetabular roof (HP:0003180)1.80862353
86Joint contractures involving the joints of the feet (HP:0100492)1.80638461
87Flexion contracture of toe (HP:0005830)1.80638461
88Broad long bones (HP:0005622)1.80271948
89Hypercortisolism (HP:0001578)1.78968102
90Bowed forearm bones (HP:0003956)1.78170744
91Bowing of the arm (HP:0006488)1.78170744
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.77036588
93Hematochezia (HP:0002573)1.77005393
94Broad thumb (HP:0011304)1.76887654
95Inguinal hernia (HP:0000023)1.76461750
96Relative macrocephaly (HP:0004482)1.74826581
97Upper limb amyotrophy (HP:0009129)1.71183953
98Distal upper limb amyotrophy (HP:0007149)1.71183953
99Pseudobulbar signs (HP:0002200)1.70920212
100Mesomelia (HP:0003027)1.70670407
101Thoracic kyphosis (HP:0002942)1.70342991
102Osteopenia (HP:0000938)1.70202553
103Selective tooth agenesis (HP:0001592)1.68881962
104Elfin facies (HP:0004428)1.68834749
105Narrow palate (HP:0000189)1.68725929
106Spinal rigidity (HP:0003306)1.68581998
107Spondylolisthesis (HP:0003302)1.68175526
108Patellar dislocation (HP:0002999)1.67663649
109Broad distal phalanx of finger (HP:0009836)1.67524073
110Abnormality of the diencephalon (HP:0010662)1.66725696
111Broad phalanges of the hand (HP:0009768)1.66234693
112Venous abnormality (HP:0002624)1.65984596
113Genu valgum (HP:0002857)1.65609333
114Broad face (HP:0000283)1.65419481
115Hand muscle atrophy (HP:0009130)1.64527531
116Abnormality of the frontal sinuses (HP:0002687)1.61878650
117Nuclear cataract (HP:0100018)1.61763902
118Hypoventilation (HP:0002791)1.61748009
119Protruding ear (HP:0000411)1.61296771
120Bronchomalacia (HP:0002780)1.61059788
121Short nail (HP:0001799)1.60851772
122Choanal stenosis (HP:0000452)1.59817841
123Arachnodactyly (HP:0001166)1.58545464
124Hammertoe (HP:0001765)1.58153218
125Nonimmune hydrops fetalis (HP:0001790)1.58132771
126Tarsal synostosis (HP:0008368)1.57726319
127Megalocornea (HP:0000485)1.56737353
128Abnormal cortical bone morphology (HP:0003103)1.55848403
129Osteoarthritis (HP:0002758)1.55236369
130Broad phalanx (HP:0006009)1.55081619
131Termporal pattern (HP:0011008)1.54738196
132Insidious onset (HP:0003587)1.54738196
133Deviation of the thumb (HP:0009603)1.54522973
134Urinary glycosaminoglycan excretion (HP:0003541)1.54369444
135Mucopolysacchariduria (HP:0008155)1.54369444
136Pectus excavatum (HP:0000767)1.54313118
137Spastic diplegia (HP:0001264)1.54294415
138Elbow flexion contracture (HP:0002987)1.54161932
139Broad finger (HP:0001500)1.52691775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.12654202
2PKN23.49502411
3PDGFRA3.06337882
4DDR22.79866757
5LATS12.46708296
6PTK62.29078317
7RIPK12.26574122
8ERN12.17885686
9PRPF4B2.14567625
10TTN2.10849493
11EEF2K2.08827427
12LATS22.00360491
13IRAK31.99823851
14EPHA31.97861983
15SIK11.90534052
16SMG11.87042122
17PNCK1.83984189
18MAP3K101.73102229
19PTK21.68942756
20SCYL21.67127743
21TESK11.65832718
22LRRK21.65735034
23BMX1.64475282
24KSR21.59757388
25FER1.57948796
26RET1.53293964
27MAP3K21.50979335
28PRKD31.47865240
29FGFR41.41135267
30PAK41.34652750
31DMPK1.33729360
32PDGFRB1.33515981
33EPHB21.32671995
34CAMK1D1.29486269
35CDK61.29388261
36FGFR31.29350759
37FRK1.29233841
38NTRK11.28545291
39FGFR11.26072636
40PAK21.25881068
41PAK31.25673237
42ERBB41.22377940
43MOS1.21252875
44FGFR21.20723225
45CAMK1G1.16222724
46LIMK11.13855306
47STK241.08386909
48EPHB11.06587924
49TGFBR11.06488779
50STK31.05565977
51ILK1.02555122
52MARK21.02475631
53MAP3K131.02448827
54MTOR1.01851376
55LMTK21.01286664
56CAMKK10.98928667
57DYRK1B0.94589244
58PRKCH0.92447876
59WNK10.92343853
60TYRO30.90711722
61KSR10.90423018
62MAP2K10.90235548
63PRKD20.88943325
64TNIK0.87893647
65JAK10.84496173
66PAK60.81426269
67PTK2B0.80704789
68MELK0.79964846
69FGR0.79376171
70MARK30.79316220
71ERBB30.78278997
72TGFBR20.76515636
73CLK10.76236203
74ERBB20.73418530
75CDK40.72816977
76ALK0.70748989
77RPS6KA20.70575444
78NEK90.67563441
79RPS6KA40.67508711
80ICK0.64663882
81IRAK20.64151487
82RPS6KC10.63875660
83RPS6KL10.63875660
84MINK10.63856873
85TAOK10.63807388
86TAF10.61441152
87MAP3K90.59823275
88NEK20.59613496
89ROCK10.58448604
90CHUK0.57854831
91STK38L0.56799347
92CDK80.56440959
93YES10.55713230
94MAP3K70.54888803
95JAK30.54368787
96MAP3K60.54251815
97DAPK20.52846361
98JAK20.51630610
99NEK10.50427750
100MARK10.49928706
101SGK30.48896792
102CDK90.48870507
103SRC0.48036299
104SIK20.46361037
105RPS6KA60.45604915
106STK380.43244788
107ACVR1B0.42436265
108CDK120.42231854
109CDK150.40536945
110IGF1R0.39091823
111MATK0.38904132
112MST1R0.37550402
113PRKD10.37275762
114MET0.36255909
115PASK0.36159246
116ARAF0.36123931
117MAP3K10.35672259
118CDK11A0.34699773
119INSR0.34558095
120HIPK20.34491523
121CDK180.34268733
122CHEK10.34211492
123CAMKK20.33856743
124NTRK20.32529036
125CDC70.32357865
126CHEK20.31747532
127MAP3K80.31178663
128EGFR0.30768301
129GSK3A0.30736575
130CDC42BPA0.30617679
131FLT30.30462985
132TBK10.30378457
133PIK3CA0.30267722
134CSNK1A1L0.29529759
135ROCK20.28670310
136CDK140.28389305
137PRKG20.28349742
138STK100.27805149

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.27389064
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08627322
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.94641982
4ECM-receptor interaction_Homo sapiens_hsa045121.88161213
5Focal adhesion_Homo sapiens_hsa045101.86731452
6Chronic myeloid leukemia_Homo sapiens_hsa052201.77802482
7Proteoglycans in cancer_Homo sapiens_hsa052051.77146735
8Notch signaling pathway_Homo sapiens_hsa043301.74337992
9Adherens junction_Homo sapiens_hsa045201.62431706
10Bladder cancer_Homo sapiens_hsa052191.60646519
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58914537
12Glioma_Homo sapiens_hsa052141.51690586
13Amoebiasis_Homo sapiens_hsa051461.50995100
14Endometrial cancer_Homo sapiens_hsa052131.49625210
15Other glycan degradation_Homo sapiens_hsa005111.43342450
16Small cell lung cancer_Homo sapiens_hsa052221.40396818
17Pancreatic cancer_Homo sapiens_hsa052121.37331676
18Caffeine metabolism_Homo sapiens_hsa002321.34967424
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32120341
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31890731
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.29803347
22mTOR signaling pathway_Homo sapiens_hsa041501.24369970
23Selenocompound metabolism_Homo sapiens_hsa004501.23627742
24Hippo signaling pathway_Homo sapiens_hsa043901.18159708
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17047271
26TGF-beta signaling pathway_Homo sapiens_hsa043501.16155046
27MicroRNAs in cancer_Homo sapiens_hsa052061.15924783
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.15900628
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15485011
30Toxoplasmosis_Homo sapiens_hsa051451.13895444
31Galactose metabolism_Homo sapiens_hsa000521.13198990
32Colorectal cancer_Homo sapiens_hsa052101.13076986
33Prolactin signaling pathway_Homo sapiens_hsa049171.11692720
34Viral myocarditis_Homo sapiens_hsa054161.11577934
35Protein digestion and absorption_Homo sapiens_hsa049741.10934062
36Insulin resistance_Homo sapiens_hsa049311.09008213
37Non-small cell lung cancer_Homo sapiens_hsa052231.07031727
38Estrogen signaling pathway_Homo sapiens_hsa049151.06200987
39VEGF signaling pathway_Homo sapiens_hsa043701.02781128
40Lysosome_Homo sapiens_hsa041421.02491114
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01890533
42Melanoma_Homo sapiens_hsa052181.01412699
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01208205
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00352910
45Prostate cancer_Homo sapiens_hsa052150.99545772
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97823381
47Shigellosis_Homo sapiens_hsa051310.96252864
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94890080
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93420196
50Renal cell carcinoma_Homo sapiens_hsa052110.92690288
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.92564091
52Platelet activation_Homo sapiens_hsa046110.90540426
53Wnt signaling pathway_Homo sapiens_hsa043100.90202796
54Thyroid cancer_Homo sapiens_hsa052160.89604731
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88044602
56Leishmaniasis_Homo sapiens_hsa051400.87613160
57Rap1 signaling pathway_Homo sapiens_hsa040150.87251209
58Type II diabetes mellitus_Homo sapiens_hsa049300.85376139
59TNF signaling pathway_Homo sapiens_hsa046680.84414631
60Insulin signaling pathway_Homo sapiens_hsa049100.83596515
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81861496
62B cell receptor signaling pathway_Homo sapiens_hsa046620.81516824
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.81334909
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.80915251
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80826731
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79061605
67Gap junction_Homo sapiens_hsa045400.79009772
68Choline metabolism in cancer_Homo sapiens_hsa052310.77301503
69Dilated cardiomyopathy_Homo sapiens_hsa054140.77299878
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77088359
71Basal cell carcinoma_Homo sapiens_hsa052170.76893616
72Axon guidance_Homo sapiens_hsa043600.76704455
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76257593
74Sphingolipid metabolism_Homo sapiens_hsa006000.76221145
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75564782
76Hepatitis B_Homo sapiens_hsa051610.75325366
77Melanogenesis_Homo sapiens_hsa049160.75037048
78Dorso-ventral axis formation_Homo sapiens_hsa043200.74749038
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74746581
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74314123
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73402419
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73003668
83Bile secretion_Homo sapiens_hsa049760.72116854
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72030947
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71575725
86Acute myeloid leukemia_Homo sapiens_hsa052210.71400000
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.71050569
88Osteoclast differentiation_Homo sapiens_hsa043800.68557479
89AMPK signaling pathway_Homo sapiens_hsa041520.67605181
90Hedgehog signaling pathway_Homo sapiens_hsa043400.67326693
91Pathways in cancer_Homo sapiens_hsa052000.66815147
92Prion diseases_Homo sapiens_hsa050200.66674539
93Thyroid hormone synthesis_Homo sapiens_hsa049180.66440377
94Chemokine signaling pathway_Homo sapiens_hsa040620.66432003
95Ras signaling pathway_Homo sapiens_hsa040140.66057981
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65718664
97Endocytosis_Homo sapiens_hsa041440.64744523
98ErbB signaling pathway_Homo sapiens_hsa040120.63635164
99Glucagon signaling pathway_Homo sapiens_hsa049220.63557085
100FoxO signaling pathway_Homo sapiens_hsa040680.63126962
101GnRH signaling pathway_Homo sapiens_hsa049120.62789054
102Hepatitis C_Homo sapiens_hsa051600.59918165
103Lysine degradation_Homo sapiens_hsa003100.59836231
104Salmonella infection_Homo sapiens_hsa051320.59425596
105Cocaine addiction_Homo sapiens_hsa050300.59242384
106N-Glycan biosynthesis_Homo sapiens_hsa005100.58688320
107HIF-1 signaling pathway_Homo sapiens_hsa040660.58537213
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.58245322
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56120229
110PPAR signaling pathway_Homo sapiens_hsa033200.55483352
111Complement and coagulation cascades_Homo sapiens_hsa046100.54976127
112HTLV-I infection_Homo sapiens_hsa051660.54845711
113Tight junction_Homo sapiens_hsa045300.54047271
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53989918
115Apoptosis_Homo sapiens_hsa042100.53722381
116Malaria_Homo sapiens_hsa051440.53680606
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53139579
118Inositol phosphate metabolism_Homo sapiens_hsa005620.53021635
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52645080
120MAPK signaling pathway_Homo sapiens_hsa040100.51404430
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51156180
122Cell cycle_Homo sapiens_hsa041100.50340149
123Cholinergic synapse_Homo sapiens_hsa047250.48993514

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