PTPRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.40899930
2locomotory exploration behavior (GO:0035641)4.29330658
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14741724
4ionotropic glutamate receptor signaling pathway (GO:0035235)3.94786604
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94369748
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86901905
7vocalization behavior (GO:0071625)3.69434062
8synaptic vesicle exocytosis (GO:0016079)3.68343492
9regulation of glutamate receptor signaling pathway (GO:1900449)3.67965133
10neuron cell-cell adhesion (GO:0007158)3.64976483
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.56318481
12regulation of synapse structural plasticity (GO:0051823)3.56257706
13establishment of mitochondrion localization (GO:0051654)3.52522013
14nerve growth factor signaling pathway (GO:0038180)3.51949820
15regulation of synaptic vesicle exocytosis (GO:2000300)3.51181056
16neuronal ion channel clustering (GO:0045161)3.50335635
17glutamate secretion (GO:0014047)3.47054142
18cellular potassium ion homeostasis (GO:0030007)3.38125993
19L-amino acid import (GO:0043092)3.37446180
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.36506538
21neurotransmitter-gated ion channel clustering (GO:0072578)3.35958741
22exploration behavior (GO:0035640)3.34579738
23glutamate receptor signaling pathway (GO:0007215)3.34311271
24dendrite morphogenesis (GO:0048813)3.31600295
25regulation of neuronal synaptic plasticity (GO:0048168)3.29856905
26potassium ion homeostasis (GO:0055075)3.27833120
27neuron recognition (GO:0008038)3.25075686
28layer formation in cerebral cortex (GO:0021819)3.24842144
29protein localization to synapse (GO:0035418)3.24210027
30neuronal action potential propagation (GO:0019227)3.17597898
31positive regulation of neurotransmitter secretion (GO:0001956)3.16362665
32mitochondrion transport along microtubule (GO:0047497)3.16174719
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16174719
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.15186422
35axonal fasciculation (GO:0007413)3.12824258
36regulation of synaptic vesicle transport (GO:1902803)3.12706092
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.11345032
38clathrin coat assembly (GO:0048268)3.09489739
39synaptic transmission, glutamatergic (GO:0035249)3.09439523
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.06232969
41gamma-aminobutyric acid transport (GO:0015812)3.05551170
42sodium ion export (GO:0071436)3.04038493
43presynaptic membrane assembly (GO:0097105)3.03675981
44dendritic spine morphogenesis (GO:0060997)2.95020773
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94336939
46positive regulation of neurotransmitter transport (GO:0051590)2.94115226
47cellular response to monoamine stimulus (GO:0071868)2.92553546
48cellular response to catecholamine stimulus (GO:0071870)2.92553546
49chondroitin sulfate catabolic process (GO:0030207)2.91796584
50cellular sodium ion homeostasis (GO:0006883)2.91350579
51cerebral cortex radially oriented cell migration (GO:0021799)2.86238690
52proline transport (GO:0015824)2.85858448
53presynaptic membrane organization (GO:0097090)2.85437426
54regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84954731
55long-term memory (GO:0007616)2.84264682
56negative regulation of neurotransmitter transport (GO:0051589)2.83102864
57embryonic retina morphogenesis in camera-type eye (GO:0060059)2.81939582
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81881001
59cellular response to prostaglandin stimulus (GO:0071379)2.80601953
60astrocyte development (GO:0014002)2.78382476
61amino acid import (GO:0043090)2.78273708
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77562995
63neuron-neuron synaptic transmission (GO:0007270)2.77311585
64neurotransmitter secretion (GO:0007269)2.75435331
65activation of protein kinase A activity (GO:0034199)2.74624685
66transmission of nerve impulse (GO:0019226)2.74392704
67cell migration in hindbrain (GO:0021535)2.74283080
68regulation of dendritic spine morphogenesis (GO:0061001)2.74222098
69gamma-aminobutyric acid signaling pathway (GO:0007214)2.73724553
70cerebellar Purkinje cell layer development (GO:0021680)2.72400216
71neuromuscular process controlling balance (GO:0050885)2.72380196
72cerebellar granule cell differentiation (GO:0021707)2.71073862
73vesicle transport along microtubule (GO:0047496)2.69755772
74long-term synaptic potentiation (GO:0060291)2.69433769
75regulation of synaptic plasticity (GO:0048167)2.69211286
76postsynaptic membrane organization (GO:0001941)2.69017727
77synaptic vesicle endocytosis (GO:0048488)2.67223033
78axon ensheathment in central nervous system (GO:0032291)2.66605391
79central nervous system myelination (GO:0022010)2.66605391
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.65954476
81response to auditory stimulus (GO:0010996)2.63801404
82regulation of dendritic spine development (GO:0060998)2.63719874
83regulation of postsynaptic membrane potential (GO:0060078)2.62978825
84protein localization to endosome (GO:0036010)2.61889260
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60325010
86negative regulation of neurotransmitter secretion (GO:0046929)2.60025593
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59978605
88axon extension (GO:0048675)2.59769580
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58101692
90astrocyte differentiation (GO:0048708)2.57426050
91positive regulation of membrane potential (GO:0045838)2.57172086
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56760998
93neuron projection regeneration (GO:0031102)2.56218471
94negative regulation of dendrite morphogenesis (GO:0050774)2.54560147
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.53560322
96adult walking behavior (GO:0007628)2.50199374
97regulation of ARF protein signal transduction (GO:0032012)2.49987266
98protein retention in ER lumen (GO:0006621)2.48143400
99regulation of vesicle fusion (GO:0031338)2.47538323
100dopamine receptor signaling pathway (GO:0007212)2.47337357
101neuron projection extension (GO:1990138)2.46511651
102dendritic spine organization (GO:0097061)2.45932182
103mating behavior (GO:0007617)2.44431215
104innervation (GO:0060384)2.43213225
105positive regulation of dendritic spine development (GO:0060999)2.42703713
106negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.41805978
107regulation of dendrite morphogenesis (GO:0048814)2.41449679
108cellular response to nerve growth factor stimulus (GO:1990090)2.41211721
109response to nerve growth factor (GO:1990089)2.41211721
110neuromuscular process (GO:0050905)2.40634786
111regulation of neurotransmitter secretion (GO:0046928)2.40577956
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.39805862
113establishment of nucleus localization (GO:0040023)2.39705856
114potassium ion import (GO:0010107)2.39293139
115negative regulation of axonogenesis (GO:0050771)2.39248237
116regulation of amyloid precursor protein catabolic process (GO:1902991)2.38163856
117suckling behavior (GO:0001967)2.37487771
118organelle transport along microtubule (GO:0072384)2.37349556
119cerebellar Purkinje cell differentiation (GO:0021702)2.36825967
120cortical actin cytoskeleton organization (GO:0030866)2.36665031
121positive regulation of synapse maturation (GO:0090129)2.36422690
122Rac protein signal transduction (GO:0016601)2.36341936
123regulation of ARF GTPase activity (GO:0032312)2.34312753
124membrane depolarization (GO:0051899)2.34274573
125regulation of beta-amyloid formation (GO:1902003)2.31138858
126stress fiber assembly (GO:0043149)2.30577568
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.29608440
128neurotransmitter transport (GO:0006836)2.28965171
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.28288055
130synapse assembly (GO:0007416)2.26545315
131cell communication by electrical coupling (GO:0010644)2.26083428
132regulation of Rap GTPase activity (GO:0032317)2.25857242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22713003
2GBX2_23144817_ChIP-Seq_PC3_Human3.10897027
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.94871910
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75278456
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72397030
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66302690
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49856895
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45785047
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45785047
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39477586
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38136427
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35913668
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34249869
14DROSHA_22980978_ChIP-Seq_HELA_Human2.29568429
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26190374
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25888020
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22275439
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.03678087
19* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03074075
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.99652984
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.98771022
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97512510
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.96206651
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94352501
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.94048612
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88210556
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.84821305
28AR_21572438_ChIP-Seq_LNCaP_Human1.83877808
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83250928
30REST_21632747_ChIP-Seq_MESCs_Mouse1.78401251
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75651208
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68391457
33LXR_22292898_ChIP-Seq_THP-1_Human1.64538928
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59243529
35* KDM2B_26808549_Chip-Seq_DND41_Human1.56758379
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54437354
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47462794
38* KDM2B_26808549_Chip-Seq_JURKAT_Human1.46920284
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.45621007
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.45494194
41CLOCK_20551151_ChIP-Seq_293T_Human1.45449138
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43967622
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42245201
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42209441
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.38834162
46TCF7_22412390_ChIP-Seq_EML_Mouse1.37579513
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36281945
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35991354
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.35860924
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33816955
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32117205
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31096289
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31018654
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30833933
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30196371
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29903541
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.28895102
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27881479
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27583624
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27562759
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26819066
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26534754
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24576275
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23764239
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22793835
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.20049847
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19919523
68TP53_18474530_ChIP-ChIP_U2OS_Human1.19868780
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.19790685
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.19226463
71P300_19829295_ChIP-Seq_ESCs_Human1.18024845
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16988186
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16722123
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.16536305
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16401957
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16334523
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16040345
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.14952266
79TP53_16413492_ChIP-PET_HCT116_Human1.14221709
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13609240
81AHR_22903824_ChIP-Seq_MCF-7_Human1.13150527
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.13060178
83ZNF274_21170338_ChIP-Seq_K562_Hela1.11739386
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.11691999
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.11557990
86* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11008941
87KDM2B_26808549_Chip-Seq_K562_Human1.09718489
88AR_25329375_ChIP-Seq_VCAP_Human1.09247885
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08423950
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08281671
91* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07959917
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06331418
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.06291092
94STAT3_23295773_ChIP-Seq_U87_Human1.06193624
95RXR_22108803_ChIP-Seq_LS180_Human1.05667141
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05500389
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.04164250
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04148725
99* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04057126
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03824351
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03561276
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02732116
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02175857
104AR_19668381_ChIP-Seq_PC3_Human1.00850501
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00701543
106TAF15_26573619_Chip-Seq_HEK293_Human1.00481858
107* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00309859
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.00188559
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00159347
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.00061618
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99751325
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99751325
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99596424
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98560263
115* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98400685
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.98316319
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.98265424
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98060492
119SMC4_20622854_ChIP-Seq_HELA_Human0.97282424
120TP63_17297297_ChIP-ChIP_HaCaT_Human0.96864678
121VDR_24787735_ChIP-Seq_THP-1_Human0.95531955
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94829361
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.94226425
124EGR1_19374776_ChIP-ChIP_THP-1_Human0.93882667
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93757083
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92900503
127IRF8_27001747_Chip-Seq_BMDM_Mouse0.92894541
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.92277947
129CREB1_26743006_Chip-Seq_LNCaP_Human0.92012695
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91917338
131TCF4_23295773_ChIP-Seq_U87_Human0.91620511
132POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91475823
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91275688
134IGF1R_20145208_ChIP-Seq_DFB_Human0.91159630
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90986851
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90781411
137POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90672455
138SPI1_23127762_ChIP-Seq_K562_Human0.90394976
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90013312
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89996937
141CTCF_27219007_Chip-Seq_Bcells_Human0.89712157
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89073086
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.88967538
144SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88262084
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87245116
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.86593813
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86194264
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.84959926
149SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84152858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05096850
2MP0003880_abnormal_central_pattern4.13896913
3MP0003635_abnormal_synaptic_transmissio3.44851541
4MP0003122_maternal_imprinting2.99017214
5MP0004270_analgesia2.92146260
6MP0002064_seizures2.78349736
7MP0009745_abnormal_behavioral_response2.75455628
8* MP0002063_abnormal_learning/memory/cond2.67335034
9MP0004858_abnormal_nervous_system2.52516188
10MP0003690_abnormal_glial_cell2.37233447
11MP0009046_muscle_twitch2.32575167
12MP0001968_abnormal_touch/_nociception2.31841684
13MP0000569_abnormal_digit_pigmentation2.31731556
14MP0003172_abnormal_lysosome_physiology2.25627915
15MP0000920_abnormal_myelination2.22721850
16MP0003329_amyloid_beta_deposits2.16676365
17* MP0002572_abnormal_emotion/affect_behav2.14867985
18MP0002735_abnormal_chemical_nociception2.13502756
19MP0002736_abnormal_nociception_after2.05404581
20MP0005058_abnormal_lysosome_morphology2.04481402
21MP0001486_abnormal_startle_reflex2.03987445
22MP0002272_abnormal_nervous_system2.03332842
23MP0002734_abnormal_mechanical_nocicepti2.01407446
24MP0004885_abnormal_endolymph1.96506880
25MP0003123_paternal_imprinting1.94621067
26MP0000778_abnormal_nervous_system1.88697564
27MP0008569_lethality_at_weaning1.82073100
28MP0005423_abnormal_somatic_nervous1.80410631
29MP0001440_abnormal_grooming_behavior1.79168236
30MP0000604_amyloidosis1.76840449
31MP0001501_abnormal_sleep_pattern1.76657563
32MP0003303_peritoneal_inflammation1.75383487
33MP0009780_abnormal_chondrocyte_physiolo1.74484152
34MP0003634_abnormal_glial_cell1.72935712
35MP0003075_altered_response_to1.66887274
36MP0001970_abnormal_pain_threshold1.66441290
37MP0002733_abnormal_thermal_nociception1.63908339
38MP0002067_abnormal_sensory_capabilities1.62592336
39MP0005171_absent_coat_pigmentation1.61119697
40MP0003633_abnormal_nervous_system1.57543574
41MP0003705_abnormal_hypodermis_morpholog1.49258780
42MP0004811_abnormal_neuron_physiology1.48236465
43MP0005623_abnormal_meninges_morphology1.43272535
44MP0000955_abnormal_spinal_cord1.41007587
45MP0002909_abnormal_adrenal_gland1.39635638
46MP0002184_abnormal_innervation1.37687574
47MP0008438_abnormal_cutaneous_collagen1.35911298
48MP0009278_abnormal_bone_marrow1.33512794
49MP0004510_myositis1.32997894
50MP0000566_synostosis1.29034190
51MP0003631_nervous_system_phenotype1.28039828
52MP0004742_abnormal_vestibular_system1.27450449
53MP0005167_abnormal_blood-brain_barrier1.27051962
54MP0005386_behavior/neurological_phenoty1.26995785
55MP0004924_abnormal_behavior1.26995785
56MP0005257_abnormal_intraocular_pressure1.26378322
57* MP0002557_abnormal_social/conspecific_i1.25869559
58* MP0002882_abnormal_neuron_morphology1.22993666
59MP0005645_abnormal_hypothalamus_physiol1.19615560
60MP0003121_genomic_imprinting1.19421431
61* MP0002066_abnormal_motor_capabilities/c1.16038864
62MP0002653_abnormal_ependyma_morphology1.14214017
63MP0002822_catalepsy1.13395702
64MP0003283_abnormal_digestive_organ1.10036635
65MP0001958_emphysema1.07476220
66MP0001905_abnormal_dopamine_level1.06474685
67MP0000015_abnormal_ear_pigmentation1.06050324
68MP0003632_abnormal_nervous_system1.05843128
69MP0003300_gastrointestinal_ulcer1.04817894
70MP0002877_abnormal_melanocyte_morpholog1.04628377
71MP0005409_darkened_coat_color1.03995458
72MP0001849_ear_inflammation1.02287447
73MP0001502_abnormal_circadian_rhythm1.01542727
74MP0005174_abnormal_tail_pigmentation0.99250366
75MP0003861_abnormal_nervous_system0.98046461
76MP0000534_abnormal_ureter_morphology0.97806162
77MP0002090_abnormal_vision0.97186180
78MP0001299_abnormal_eye_distance/0.94621232
79MP0002229_neurodegeneration0.94604279
80MP0001915_intracranial_hemorrhage0.94575507
81MP0010386_abnormal_urinary_bladder0.91247858
82* MP0002152_abnormal_brain_morphology0.91212802
83MP0002249_abnormal_larynx_morphology0.90589456
84MP0001177_atelectasis0.89926294
85MP0005646_abnormal_pituitary_gland0.89222102
86MP0005248_abnormal_Harderian_gland0.88396990
87MP0004185_abnormal_adipocyte_glucose0.87050279
88MP0005166_decreased_susceptibility_to0.85855320
89MP0004130_abnormal_muscle_cell0.85614946
90* MP0002089_abnormal_postnatal_growth/wei0.85169715
91MP0008260_abnormal_autophagy0.83443163
92MP0001188_hyperpigmentation0.81499732
93MP0003787_abnormal_imprinting0.80981319
94MP0003879_abnormal_hair_cell0.80639406
95MP0008874_decreased_physiological_sensi0.79317874
96MP0001984_abnormal_olfaction0.78194608
97MP0001346_abnormal_lacrimal_gland0.76650433
98MP0003183_abnormal_peptide_metabolism0.76480543
99MP0001963_abnormal_hearing_physiology0.76099961
100MP0005076_abnormal_cell_differentiation0.75853116
101MP0002998_abnormal_bone_remodeling0.75386553
102MP0002896_abnormal_bone_mineralization0.75380649
103MP0003115_abnormal_respiratory_system0.73764624
104MP0005666_abnormal_adipose_tissue0.73728521
105MP0001348_abnormal_lacrimal_gland0.72388775
106MP0004142_abnormal_muscle_tone0.71387881
107MP0001943_abnormal_respiration0.71122927
108MP0003091_abnormal_cell_migration0.71113191
109MP0005464_abnormal_platelet_physiology0.70644958
110MP0006082_CNS_inflammation0.69521950
111MP0003942_abnormal_urinary_system0.67287421
112MP0003045_fibrosis0.66821553
113MP0010769_abnormal_survival0.65334958
114MP0005310_abnormal_salivary_gland0.65180943
115MP0002116_abnormal_craniofacial_bone0.64927374
116MP0000751_myopathy0.64244583
117MP0000013_abnormal_adipose_tissue0.64239700
118MP0006276_abnormal_autonomic_nervous0.64192478
119MP0003385_abnormal_body_wall0.64130414
120MP0001485_abnormal_pinna_reflex0.63749188
121MP0004484_altered_response_of0.61697886
122MP0000747_muscle_weakness0.58857294
123MP0002069_abnormal_eating/drinking_beha0.57858805
124MP0002419_abnormal_innate_immunity0.54871606
125MP0002133_abnormal_respiratory_system0.54698929
126MP0005388_respiratory_system_phenotype0.54698929
127MP0005595_abnormal_vascular_smooth0.52950322
128MP0004134_abnormal_chest_morphology0.48561562
129MP0010678_abnormal_skin_adnexa0.48403501
130MP0002752_abnormal_somatic_nervous0.48394768

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.72811338
2Supranuclear gaze palsy (HP:0000605)4.68535634
3Neurofibrillary tangles (HP:0002185)4.39627340
4Myokymia (HP:0002411)4.19475466
5Increased cerebral lipofuscin (HP:0011813)3.92225989
6Cerebral inclusion bodies (HP:0100314)3.88224248
7Focal seizures (HP:0007359)3.86951718
8Visual hallucinations (HP:0002367)3.50159201
9Mutism (HP:0002300)3.43354737
10Papilledema (HP:0001085)3.35125799
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.28614886
12Action tremor (HP:0002345)3.17886312
13Ankle clonus (HP:0011448)3.09978473
14Hyperacusis (HP:0010780)3.03867116
15Epileptic encephalopathy (HP:0200134)2.93919058
16Diplopia (HP:0000651)2.92217208
17Abnormality of binocular vision (HP:0011514)2.92217208
18Apathy (HP:0000741)2.92083134
19Protrusio acetabuli (HP:0003179)2.80608569
20Akinesia (HP:0002304)2.79630693
21Dysostosis multiplex (HP:0000943)2.76720178
22Intention tremor (HP:0002080)2.75283602
23Abnormality of glycolipid metabolism (HP:0010969)2.72354363
24Abnormality of liposaccharide metabolism (HP:0010968)2.72354363
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.72354363
26Neuronal loss in central nervous system (HP:0002529)2.70221758
27Megalencephaly (HP:0001355)2.69015013
28Diminished motivation (HP:0000745)2.67539390
29Dysmetria (HP:0001310)2.66124736
30Neonatal short-limb short stature (HP:0008921)2.65025300
31Atonic seizures (HP:0010819)2.64462508
32Depression (HP:0000716)2.59096262
33Generalized tonic-clonic seizures (HP:0002069)2.53720591
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51808246
35Turricephaly (HP:0000262)2.47853166
36Progressive cerebellar ataxia (HP:0002073)2.46247578
37Inappropriate behavior (HP:0000719)2.44380542
38Abnormality of the lower motor neuron (HP:0002366)2.43653616
39Postural instability (HP:0002172)2.41626892
40Disinhibition (HP:0000734)2.40533108
41Dialeptic seizures (HP:0011146)2.39906770
42Abnormal eating behavior (HP:0100738)2.36713714
43Absence seizures (HP:0002121)2.33431907
44Arterial tortuosity (HP:0005116)2.32025800
45Progressive inability to walk (HP:0002505)2.31347871
46Truncal ataxia (HP:0002078)2.30200238
47Amblyopia (HP:0000646)2.26626845
48Febrile seizures (HP:0002373)2.24179317
49Spastic gait (HP:0002064)2.23760019
50Dysdiadochokinesis (HP:0002075)2.20209622
51J-shaped sella turcica (HP:0002680)2.18815080
52Lower limb muscle weakness (HP:0007340)2.17944914
53Hand muscle atrophy (HP:0009130)2.17129286
54Abnormality of the corticospinal tract (HP:0002492)2.16527592
55Stereotypic behavior (HP:0000733)2.16372037
56Mild short stature (HP:0003502)2.14965949
57Peripheral hypomyelination (HP:0007182)2.14698696
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14570913
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.14570913
60Urinary urgency (HP:0000012)2.13751217
61Termporal pattern (HP:0011008)2.12966042
62Insidious onset (HP:0003587)2.12966042
63Gaze-evoked nystagmus (HP:0000640)2.11998927
64Hemiplegia (HP:0002301)2.11487130
65Vascular tortuosity (HP:0004948)2.10905294
66Bronchomalacia (HP:0002780)2.10655483
67Cerebral aneurysm (HP:0004944)2.10255660
68Overriding aorta (HP:0002623)2.07972017
69Shallow orbits (HP:0000586)2.07598479
70Hammertoe (HP:0001765)2.06646186
71Excessive salivation (HP:0003781)2.06340499
72Drooling (HP:0002307)2.06340499
73Agitation (HP:0000713)2.06113402
74Impaired vibration sensation in the lower limbs (HP:0002166)2.05488995
75Upper limb amyotrophy (HP:0009129)2.05193874
76Distal upper limb amyotrophy (HP:0007149)2.05193874
77Elfin facies (HP:0004428)2.05151716
78Urinary bladder sphincter dysfunction (HP:0002839)2.04768940
79Anxiety (HP:0000739)2.03825944
80Renal duplication (HP:0000075)2.02772792
81Mitral regurgitation (HP:0001653)2.02029284
82Renovascular hypertension (HP:0100817)2.01624322
83Lower limb amyotrophy (HP:0007210)2.01610303
84Broad-based gait (HP:0002136)2.01374956
85Focal dystonia (HP:0004373)2.01350223
86Mucopolysacchariduria (HP:0008155)2.01061326
87Urinary glycosaminoglycan excretion (HP:0003541)2.01061326
88Scanning speech (HP:0002168)2.00764350
89Hemiparesis (HP:0001269)2.00197213
90Buphthalmos (HP:0000557)2.00049413
91Rapidly progressive (HP:0003678)1.99236926
92Postural tremor (HP:0002174)1.98802505
93Aplasia involving bones of the upper limbs (HP:0009823)1.97095806
94Aplasia of the phalanges of the hand (HP:0009802)1.97095806
95Aplasia involving bones of the extremities (HP:0009825)1.97095806
96Arnold-Chiari malformation (HP:0002308)1.95612501
97Macroorchidism (HP:0000053)1.94949573
98Insomnia (HP:0100785)1.94925237
99Craniofacial dystonia (HP:0012179)1.94812710
100Abnormality of polysaccharide metabolism (HP:0011012)1.94679275
101Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94679275
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94679275
103Retinal dysplasia (HP:0007973)1.94675996
104Clumsiness (HP:0002312)1.93280577
105Bladder diverticulum (HP:0000015)1.92936779
106Bowel diverticulosis (HP:0005222)1.92549081
107Broad palm (HP:0001169)1.89274965
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88958385
109Poor eye contact (HP:0000817)1.88080902
110Loss of speech (HP:0002371)1.85819841
111Lower limb asymmetry (HP:0100559)1.85750848
112Annular pancreas (HP:0001734)1.85549590
113Heterotopia (HP:0002282)1.83821929
114Bowel incontinence (HP:0002607)1.83561917
115Onion bulb formation (HP:0003383)1.83408702
116Vertebral arch anomaly (HP:0008438)1.83362827
117Global brain atrophy (HP:0002283)1.82181564
118Psychosis (HP:0000709)1.81871984
119Dementia (HP:0000726)1.78615584
120Polyphagia (HP:0002591)1.77491359
121Obstructive sleep apnea (HP:0002870)1.76985191
122Tetraplegia (HP:0002445)1.76068411
123Aqueductal stenosis (HP:0002410)1.75042075
124Axonal loss (HP:0003447)1.74980286
125Type II lissencephaly (HP:0007260)1.74786569
126Decreased motor nerve conduction velocity (HP:0003431)1.73368024
127Torticollis (HP:0000473)1.72999572
128Impaired social interactions (HP:0000735)1.72910225
129Abnormal social behavior (HP:0012433)1.72910225
130Sleep apnea (HP:0010535)1.72217812
131Atelectasis (HP:0100750)1.71511014
132Ankyloglossia (HP:0010296)1.70453537
133Pointed chin (HP:0000307)1.70314571
134Widely spaced teeth (HP:0000687)1.69906782
135Abnormality of the diencephalon (HP:0010662)1.69349363
136Abnormal large intestine physiology (HP:0012700)1.63574649
137Bradykinesia (HP:0002067)1.61976999
138Trigonocephaly (HP:0000243)1.61721593
139Thickened helices (HP:0000391)1.60641064
140Supernumerary nipples (HP:0002558)1.59234896
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59106777
142Abnormality of dentin (HP:0010299)1.58992416
143Hepatoblastoma (HP:0002884)1.58958374
144Deep palmar crease (HP:0006191)1.57540654
145Hypercortisolism (HP:0001578)1.56544536
146Deep venous thrombosis (HP:0002625)1.55955694
147Broad face (HP:0000283)1.55780235
148Coronal craniosynostosis (HP:0004440)1.55585519
149Wormian bones (HP:0002645)1.55572580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.75020638
2EPHA43.53438766
3MAP3K93.03650710
4MARK12.77771613
5RIPK42.52100791
6KSR22.26443695
7MAP3K132.23750892
8NTRK12.08812457
9CAMKK11.93519065
10FES1.93293479
11PAK61.91255999
12MINK11.87620561
13DAPK21.78214362
14LATS21.77604564
15PRPF4B1.71007128
16ICK1.69181978
17NTRK21.68258818
18CDK121.65512076
19CAMKK21.64378204
20FGFR41.64241479
21MAP3K41.62617140
22SIK21.52072085
23MAP3K21.50381783
24CDK51.49245551
25CASK1.39465315
26PLK21.38882182
27SCYL21.36671307
28TRIB31.34976299
29PRKD31.33954630
30TNIK1.30129951
31OXSR11.29378396
32FGFR31.26597525
33ARAF1.26451450
34MAP2K71.19697693
35MAPKAPK51.18231106
36PRKCH1.17117037
37PTK2B1.16921018
38SGK4941.16498747
39SGK2231.16498747
40RET1.16032753
41KSR11.14726930
42CDK191.12430918
43CAMK1G1.09995461
44TYRO31.05669883
45FGR1.05528280
46EPHB21.03829742
47MAP3K121.03428834
48MAPK131.00850361
49STK391.00036451
50EEF2K0.96254495
51UHMK10.95646611
52PHKG20.95450691
53PHKG10.95450691
54CSNK1G20.92127637
55PNCK0.89668240
56EPHB10.88995593
57BMPR20.86969194
58LMTK20.86218284
59PDPK10.85244810
60FYN0.84447124
61SGK30.81989851
62FGFR20.80900552
63ROCK20.80007290
64DAPK10.79335429
65STK110.79231352
66PKN10.79031587
67NEK60.77406381
68PDK10.76957463
69PRKCG0.76478151
70CAMK2B0.76383965
71MAPK100.75790670
72CDK140.75086452
73SGK20.74495686
74MAP2K40.74221176
75DMPK0.73700639
76* CAMK2A0.72738256
77CDK150.71528490
78SMG10.71284501
79PDGFRB0.70444532
80RAF10.70229766
81CAMK1D0.70223967
82SGK10.69102467
83MARK20.68915713
84CDK180.68804573
85PDGFRA0.68738179
86GRK50.68019018
87HCK0.67791775
88ERBB20.65461327
89PRKCE0.64826118
90STK380.64006330
91DDR20.63606176
92BRD40.63007813
93MOS0.62892118
94CAMK10.61183016
95TNK20.61121149
96TESK10.60946532
97ERBB30.59420134
98MAP3K10.58764368
99JAK10.58582849
100CDK11A0.58457019
101PAK30.56604459
102MTOR0.55746283
103SIK10.55634914
104PTK20.55520122
105WNK10.54529335
106CSNK1A1L0.54319851
107HIPK20.54052989
108KIT0.53350106
109ALK0.53089342
110MAP3K100.51046844
111DYRK1B0.50685946
112CSNK1G30.49359878
113SYK0.49026994
114FER0.48968953
115RIPK10.48654779
116BMX0.48534523
117PRKD20.48195494
118MAP3K70.47596776
119LRRK20.46201183
120DYRK1A0.45687374
121PRKD10.45407623
122BRAF0.45165666
123TAOK10.43944374
124* SRC0.43633758
125PKN20.43560254
126MAPK120.42132478
127PAK20.41306363
128YES10.40920335
129CDC42BPA0.40121893

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.22848619
2Nicotine addiction_Homo sapiens_hsa050332.19460941
3Olfactory transduction_Homo sapiens_hsa047402.07669862
4Long-term potentiation_Homo sapiens_hsa047202.03449648
5Circadian entrainment_Homo sapiens_hsa047132.02687477
6Glutamatergic synapse_Homo sapiens_hsa047242.00543426
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89539161
8GABAergic synapse_Homo sapiens_hsa047271.86174940
9Morphine addiction_Homo sapiens_hsa050321.82810041
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79862657
11Salivary secretion_Homo sapiens_hsa049701.73287727
12Gastric acid secretion_Homo sapiens_hsa049711.61030327
13Long-term depression_Homo sapiens_hsa047301.59479304
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55573217
15Cholinergic synapse_Homo sapiens_hsa047251.55353977
16Dopaminergic synapse_Homo sapiens_hsa047281.54641354
17Amphetamine addiction_Homo sapiens_hsa050311.52345936
18Renin secretion_Homo sapiens_hsa049241.50448952
19Glioma_Homo sapiens_hsa052141.38050236
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36152493
21Collecting duct acid secretion_Homo sapiens_hsa049661.32483800
22Oxytocin signaling pathway_Homo sapiens_hsa049211.30911239
23Axon guidance_Homo sapiens_hsa043601.30544947
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29537383
25GnRH signaling pathway_Homo sapiens_hsa049121.29229902
26Serotonergic synapse_Homo sapiens_hsa047261.27981377
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26236690
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23256465
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21639221
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20929540
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20205629
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20037893
33Lysosome_Homo sapiens_hsa041421.19305399
34Insulin secretion_Homo sapiens_hsa049111.16963309
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.14994678
36Calcium signaling pathway_Homo sapiens_hsa040201.13679728
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13016027
38Cocaine addiction_Homo sapiens_hsa050301.12584012
39Gap junction_Homo sapiens_hsa045401.11883671
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08576896
41cAMP signaling pathway_Homo sapiens_hsa040241.08542714
42Estrogen signaling pathway_Homo sapiens_hsa049151.08304270
43Notch signaling pathway_Homo sapiens_hsa043301.07166734
44Vibrio cholerae infection_Homo sapiens_hsa051101.05163607
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03295884
46Taste transduction_Homo sapiens_hsa047421.02459053
47Colorectal cancer_Homo sapiens_hsa052101.01664292
48ErbB signaling pathway_Homo sapiens_hsa040121.00495812
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00306346
50Adherens junction_Homo sapiens_hsa045200.99211182
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.98154810
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.96847280
53Type II diabetes mellitus_Homo sapiens_hsa049300.96817471
54mTOR signaling pathway_Homo sapiens_hsa041500.93485854
55Melanogenesis_Homo sapiens_hsa049160.92671131
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.92196746
57Endocytosis_Homo sapiens_hsa041440.91791645
58Renal cell carcinoma_Homo sapiens_hsa052110.91134283
59Dorso-ventral axis formation_Homo sapiens_hsa043200.90805207
60Osteoclast differentiation_Homo sapiens_hsa043800.90308059
61Phagosome_Homo sapiens_hsa041450.90282556
62VEGF signaling pathway_Homo sapiens_hsa043700.88735695
63Chemokine signaling pathway_Homo sapiens_hsa040620.85355259
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84674665
65Platelet activation_Homo sapiens_hsa046110.84410428
66B cell receptor signaling pathway_Homo sapiens_hsa046620.84011158
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83376322
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83255364
69Choline metabolism in cancer_Homo sapiens_hsa052310.82509433
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.82217651
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81772607
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.81502858
73ECM-receptor interaction_Homo sapiens_hsa045120.80261639
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77520686
75Non-small cell lung cancer_Homo sapiens_hsa052230.77299038
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77173627
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77076882
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77058171
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75743741
80Rheumatoid arthritis_Homo sapiens_hsa053230.74962009
81Rap1 signaling pathway_Homo sapiens_hsa040150.74431419
82Salmonella infection_Homo sapiens_hsa051320.73039739
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72690505
84Ras signaling pathway_Homo sapiens_hsa040140.72083781
85Tuberculosis_Homo sapiens_hsa051520.72059059
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70226035
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69609973
88Wnt signaling pathway_Homo sapiens_hsa043100.69405183
89Pancreatic secretion_Homo sapiens_hsa049720.69336007
90MAPK signaling pathway_Homo sapiens_hsa040100.69133641
91Insulin signaling pathway_Homo sapiens_hsa049100.68688415
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68418091
93Dilated cardiomyopathy_Homo sapiens_hsa054140.67744757
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67333423
95Thyroid hormone synthesis_Homo sapiens_hsa049180.66688502
96Bile secretion_Homo sapiens_hsa049760.66625065
97Prolactin signaling pathway_Homo sapiens_hsa049170.66587536
98Acute myeloid leukemia_Homo sapiens_hsa052210.64550853
99Pancreatic cancer_Homo sapiens_hsa052120.64254716
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63396312
101Hippo signaling pathway_Homo sapiens_hsa043900.62809344
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62643446
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62465465
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62428684
105AMPK signaling pathway_Homo sapiens_hsa041520.62409911
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61151358
107Focal adhesion_Homo sapiens_hsa045100.61104303
108MicroRNAs in cancer_Homo sapiens_hsa052060.59962269
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.59709036
110Amoebiasis_Homo sapiens_hsa051460.57348301
111Endometrial cancer_Homo sapiens_hsa052130.57338170
112Pertussis_Homo sapiens_hsa051330.56650515
113Nitrogen metabolism_Homo sapiens_hsa009100.55835472
114Chronic myeloid leukemia_Homo sapiens_hsa052200.55832526
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55416392
116Prion diseases_Homo sapiens_hsa050200.55410085
117Other glycan degradation_Homo sapiens_hsa005110.55408454
118HIF-1 signaling pathway_Homo sapiens_hsa040660.54533876
119Hedgehog signaling pathway_Homo sapiens_hsa043400.53321194
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53000659
121Proteoglycans in cancer_Homo sapiens_hsa052050.52700309
122Ovarian steroidogenesis_Homo sapiens_hsa049130.52440971
123Inositol phosphate metabolism_Homo sapiens_hsa005620.52186539

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