PTPRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.27175954
2vascular endothelial growth factor signaling pathway (GO:0038084)6.65350935
3endothelium development (GO:0003158)6.03481774
4surfactant homeostasis (GO:0043129)5.74568646
5retina vasculature morphogenesis in camera-type eye (GO:0061299)5.07164918
6cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.01211712
7positive regulation of vasculogenesis (GO:2001214)4.93571309
8lymphangiogenesis (GO:0001946)4.67814362
9chemical homeostasis within a tissue (GO:0048875)4.66108988
10regulation of endothelial cell differentiation (GO:0045601)4.57989599
11regulation of vasculogenesis (GO:2001212)4.50055181
12ovulation from ovarian follicle (GO:0001542)4.33506100
13wound healing, spreading of epidermal cells (GO:0035313)4.27130759
14blood vessel maturation (GO:0001955)4.24706601
15endothelial cell morphogenesis (GO:0001886)4.18101382
16peptidyl-tyrosine autophosphorylation (GO:0038083)4.17955769
17vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.10887448
18cell migration involved in sprouting angiogenesis (GO:0002042)3.98780425
19glomerular filtration (GO:0003094)3.93671995
20blood vessel endothelial cell migration (GO:0043534)3.93601308
21renal filtration (GO:0097205)3.79908355
22patterning of blood vessels (GO:0001569)3.79761931
23endothelial cell differentiation (GO:0045446)3.70269014
24endothelial tube morphogenesis (GO:0061154)3.67067975
25morphogenesis of an endothelium (GO:0003159)3.67067975
26sprouting angiogenesis (GO:0002040)3.55957350
27heart trabecula formation (GO:0060347)3.44658844
28transcytosis (GO:0045056)3.42996405
29venous blood vessel morphogenesis (GO:0048845)3.42656851
30basement membrane organization (GO:0071711)3.36998743
31low-density lipoprotein particle clearance (GO:0034383)3.27596608
32fatty acid transmembrane transport (GO:1902001)3.19203555
33negative regulation of blood vessel endothelial cell migration (GO:0043537)3.11170876
34positive regulation of urine volume (GO:0035810)3.10976350
35muscle filament sliding (GO:0030049)3.07785906
36actin-myosin filament sliding (GO:0033275)3.07785906
37angiogenesis involved in wound healing (GO:0060055)3.06717453
38coronary vasculature morphogenesis (GO:0060977)3.05899521
39negative regulation of endothelial cell migration (GO:0010596)3.05341642
40negative regulation of Rho protein signal transduction (GO:0035024)3.02096675
41negative regulation of fibrinolysis (GO:0051918)2.99104237
42peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.98807107
43positive regulation of endothelial cell differentiation (GO:0045603)2.95267999
44protein localization to endosome (GO:0036010)2.91158622
45regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.88855853
46endothelial cell chemotaxis (GO:0035767)2.88810990
47regulation of blood vessel endothelial cell migration (GO:0043535)2.88460559
48regulation of establishment or maintenance of cell polarity (GO:0032878)2.88342982
49cAMP biosynthetic process (GO:0006171)2.87320899
50negative regulation of focal adhesion assembly (GO:0051895)2.86544925
51negative regulation of cell junction assembly (GO:1901889)2.86544925
52negative regulation of adherens junction organization (GO:1903392)2.86544925
53blood vessel remodeling (GO:0001974)2.86472193
54negative regulation of endothelial cell apoptotic process (GO:2000352)2.86023527
55regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.84514843
56alpha-linolenic acid metabolic process (GO:0036109)2.83206918
57vasculogenesis (GO:0001570)2.82541003
58myofibril assembly (GO:0030239)2.81231114
59endocrine hormone secretion (GO:0060986)2.81056294
60positive regulation of cell junction assembly (GO:1901890)2.81020086
61positive regulation of focal adhesion assembly (GO:0051894)2.81020086
62complement activation, alternative pathway (GO:0006957)2.79710512
63axon extension involved in axon guidance (GO:0048846)2.77943224
64neuron projection extension involved in neuron projection guidance (GO:1902284)2.77943224
65regulation of fibrinolysis (GO:0051917)2.77382788
66actin-mediated cell contraction (GO:0070252)2.76901348
67regulation of sarcomere organization (GO:0060297)2.74444203
68regulation of protein activation cascade (GO:2000257)2.73997217
69endothelial cell migration (GO:0043542)2.73582504
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73329427
71L-phenylalanine catabolic process (GO:0006559)2.73329427
72response to mercury ion (GO:0046689)2.73274559
73negative regulation of angiogenesis (GO:0016525)2.72032486
74nephron epithelium development (GO:0072009)2.71835328
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69547595
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.68703033
77negative regulation of platelet activation (GO:0010544)2.68568140
78regulation of complement activation (GO:0030449)2.68353988
79wound healing, spreading of cells (GO:0044319)2.67933302
80negative regulation of hemostasis (GO:1900047)2.67827581
81negative regulation of blood coagulation (GO:0030195)2.67827581
82negative regulation of DNA biosynthetic process (GO:2000279)2.67819676
83cardiac myofibril assembly (GO:0055003)2.67709596
84neuron remodeling (GO:0016322)2.67055994
85negative regulation of epithelial cell migration (GO:0010633)2.65558590
86sarcomere organization (GO:0045214)2.63413910
87ovulation (GO:0030728)2.62710552
88carnitine shuttle (GO:0006853)2.61972483
89arginine catabolic process (GO:0006527)2.61456773
90negative regulation of blood vessel morphogenesis (GO:2000181)2.61442744
91positive regulation of adherens junction organization (GO:1903393)2.61256159
92embryonic heart tube development (GO:0035050)2.60950634
93artery development (GO:0060840)2.60695563
94negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.59271418
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.58502534
96adhesion of symbiont to host (GO:0044406)2.58355819
97L-phenylalanine metabolic process (GO:0006558)2.57735154
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57735154
99peptidyl-glutamic acid carboxylation (GO:0017187)2.57017436
100protein carboxylation (GO:0018214)2.57017436
101fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56631161
102Notch signaling involved in heart development (GO:0061314)2.56531814
103regulation of cholesterol storage (GO:0010885)2.54324860
104plasma lipoprotein particle clearance (GO:0034381)2.53752768
105substrate-dependent cell migration (GO:0006929)2.53473197
106negative regulation of actin filament bundle assembly (GO:0032232)2.52759071
107regulation of endothelial cell migration (GO:0010594)2.51833238
108renal absorption (GO:0070293)2.51172135
109negative regulation of complement activation (GO:0045916)2.50376096
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49210931
111regulation of axon extension involved in axon guidance (GO:0048841)2.49078439
112glomerular basement membrane development (GO:0032836)2.48775937
113triglyceride homeostasis (GO:0070328)2.48252615
114acylglycerol homeostasis (GO:0055090)2.48252615
115negative regulation of endothelial cell proliferation (GO:0001937)2.48203055
116cell volume homeostasis (GO:0006884)2.47533284
117plasma membrane repair (GO:0001778)2.46601593
118negative regulation of vasculature development (GO:1901343)2.46153968
119high-density lipoprotein particle remodeling (GO:0034375)2.45943100
120lysine metabolic process (GO:0006553)2.45843370
121lysine catabolic process (GO:0006554)2.45843370
122phagocytosis, recognition (GO:0006910)2.45233565
123regulation of actin filament-based movement (GO:1903115)2.44966603
124bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44606259
125lung vasculature development (GO:0060426)2.44104588
126fatty acid beta-oxidation (GO:0006635)2.43890752
127negative regulation of coagulation (GO:0050819)2.43083910
128regulation of epithelial cell migration (GO:0010632)2.43015613
129endothelial cell proliferation (GO:0001935)2.42949553
130triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.42129928
131blood vessel morphogenesis (GO:0048514)2.41762169
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41659219
133positive regulation of receptor recycling (GO:0001921)2.39755415
134regulation of integrin-mediated signaling pathway (GO:2001044)2.38669473
135actomyosin structure organization (GO:0031032)2.38395288
136regulation of focal adhesion assembly (GO:0051893)2.38231956
137regulation of cell-substrate junction assembly (GO:0090109)2.38231956
138regulation of endothelial cell apoptotic process (GO:2000351)2.38167581
139sodium-independent organic anion transport (GO:0043252)2.37815457
140heart valve formation (GO:0003188)2.37727197
141negative regulation of vascular permeability (GO:0043116)2.37324394
142regulation of sequestering of triglyceride (GO:0010889)2.36825794
143positive regulation of endothelial cell proliferation (GO:0001938)2.36314145
144regulation of p38MAPK cascade (GO:1900744)2.35954747
145positive regulation of endothelial cell migration (GO:0010595)2.35636405
146reverse cholesterol transport (GO:0043691)2.35567451
147* angiogenesis (GO:0001525)2.35290461
148aromatic amino acid family catabolic process (GO:0009074)2.35214571
149metanephric nephron epithelium development (GO:0072243)2.34748484
150actin filament-based movement (GO:0030048)2.34615678
151regulation of relaxation of muscle (GO:1901077)2.33834076
152regulation of adherens junction organization (GO:1903391)2.32160778
153regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.31829349
154regulation of urine volume (GO:0035809)2.31753293
155regulation of lipoprotein metabolic process (GO:0050746)2.31437026
156gap junction assembly (GO:0016264)2.31351664
157substrate adhesion-dependent cell spreading (GO:0034446)2.31047268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.17376414
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09355490
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.42103213
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.00968949
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.97689147
6CLOCK_20551151_ChIP-Seq_293T_Human2.66451698
7* GATA2_21666600_ChIP-Seq_HMVEC_Human2.60567163
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54323304
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.26981816
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.24502826
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.22415954
12GATA1_22025678_ChIP-Seq_K562_Human2.18641782
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09714331
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00906672
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91881305
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.91396468
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.76070084
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74663153
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74421229
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.73048287
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70018407
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.65951943
23* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60854577
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.59396696
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56391066
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.55082292
27* TBX20_22328084_ChIP-Seq_HEART_Mouse1.52986222
28* TBX20_22080862_ChIP-Seq_HEART_Mouse1.52986222
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50741173
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50430612
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48693351
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44395264
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39568184
34AHR_22903824_ChIP-Seq_MCF-7_Human1.38271748
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36595744
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34695611
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34069894
38* CJUN_26792858_Chip-Seq_BT549_Human1.33867333
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33054650
40EZH2_22144423_ChIP-Seq_EOC_Human1.32663908
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.32100652
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30821387
43GATA1_19941826_ChIP-Seq_K562_Human1.28003486
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.27911949
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.27118232
46ZNF263_19887448_ChIP-Seq_K562_Human1.26944269
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25938798
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25938798
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.25450112
50GBX2_23144817_ChIP-Seq_PC3_Human1.24458363
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23737074
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22025568
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21505865
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21505865
55* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19367003
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19058493
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18886761
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18471105
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18296096
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.17300994
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17021655
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15767855
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.14659797
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13045638
65SMAD4_21799915_ChIP-Seq_A2780_Human1.09728097
66BCAT_22108803_ChIP-Seq_LS180_Human1.09628280
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09185614
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.09130890
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08796976
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.07822859
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07120937
72* SOX2_20726797_ChIP-Seq_SW620_Human1.05699797
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04705429
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04305686
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03267619
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02593382
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02524790
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02462224
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.00925296
80RXR_22108803_ChIP-Seq_LS180_Human1.00765725
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00334920
82* PIAS1_25552417_ChIP-Seq_VCAP_Human0.99361446
83AR_21572438_ChIP-Seq_LNCaP_Human0.99169566
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99020756
85DROSHA_22980978_ChIP-Seq_HELA_Human0.98874722
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97466268
87VDR_22108803_ChIP-Seq_LS180_Human0.97093549
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96611994
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96528409
90* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96042185
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.95267109
92* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94280282
93ISL1_27105846_Chip-Seq_CPCs_Mouse0.91983069
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90982854
95JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90418999
96KDM2B_26808549_Chip-Seq_K562_Human0.89895051
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89550556
98NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89545450
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89535612
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89488745
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89304225
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89013768
103* BRD4_25478319_ChIP-Seq_HGPS_Human0.88680772
104RUNX_20019798_ChIP-Seq_JUKART_Human0.88121935
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.87593063
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87281848
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87087156
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87041138
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86992848
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86817974
111GATA2_19941826_ChIP-Seq_K562_Human0.86671283
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86291149
113TP53_16413492_ChIP-PET_HCT116_Human0.86103125
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86070645
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85747085
116* STAT3_23295773_ChIP-Seq_U87_Human0.85568541
117EZH2_27304074_Chip-Seq_ESCs_Mouse0.85462639
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85417495
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84998194
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84794582
121TP63_23658742_ChIP-Seq_EP156T_Human0.84225611
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84148231
123TP53_18474530_ChIP-ChIP_U2OS_Human0.84098093
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79646341
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79498014
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79378550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.42133844
2MP0001879_abnormal_lymphatic_vessel5.03108941
3MP0005167_abnormal_blood-brain_barrier4.85814483
4MP0004272_abnormal_basement_membrane4.17926890
5MP0004084_abnormal_cardiac_muscle3.09678089
6MP0003724_increased_susceptibility_to3.03889610
7MP0005360_urolithiasis2.93069735
8MP0003828_pulmonary_edema2.78880979
9MP0002139_abnormal_hepatobiliary_system2.73717588
10MP0005085_abnormal_gallbladder_physiolo2.62205023
11MP0005365_abnormal_bile_salt2.37789018
12MP0004145_abnormal_muscle_electrophysio2.33705680
13MP0002138_abnormal_hepatobiliary_system2.29399488
14MP0006138_congestive_heart_failure2.24820154
15MP0008875_abnormal_xenobiotic_pharmacok2.07428223
16MP0004036_abnormal_muscle_relaxation2.06144478
17MP0000465_gastrointestinal_hemorrhage2.00327185
18MP0004215_abnormal_myocardial_fiber1.96909222
19MP0003252_abnormal_bile_duct1.88415954
20MP0005165_increased_susceptibility_to1.82561245
21MP0005670_abnormal_white_adipose1.77366682
22MP0005330_cardiomyopathy1.75778445
23MP0004130_abnormal_muscle_cell1.73555103
24MP0004484_altered_response_of1.72978072
25MP0010329_abnormal_lipoprotein_level1.72852918
26MP0000767_abnormal_smooth_muscle1.72312323
27MP0008775_abnormal_heart_ventricle1.69246922
28MP0002837_dystrophic_cardiac_calcinosis1.68989132
29MP0003279_aneurysm1.67678537
30MP0000751_myopathy1.67182317
31MP0003646_muscle_fatigue1.63639358
32MP0003191_abnormal_cellular_cholesterol1.63337157
33MP0004147_increased_porphyrin_level1.62177561
34MP0003705_abnormal_hypodermis_morpholog1.59516498
35MP0005409_darkened_coat_color1.58162495
36MP0005385_cardiovascular_system_phenoty1.57418092
37MP0001544_abnormal_cardiovascular_syste1.57418092
38MP0005595_abnormal_vascular_smooth1.46525757
39MP0002295_abnormal_pulmonary_circulatio1.45854152
40MP0000249_abnormal_blood_vessel1.43212818
41MP0001958_emphysema1.41804777
42MP0005084_abnormal_gallbladder_morpholo1.39983005
43MP0002332_abnormal_exercise_endurance1.37697821
44MP0008004_abnormal_stomach_pH1.36753265
45MP0005623_abnormal_meninges_morphology1.32895626
46MP0002127_abnormal_cardiovascular_syste1.32267195
47MP0002972_abnormal_cardiac_muscle1.32219117
48MP0000013_abnormal_adipose_tissue1.31537604
49MP0004782_abnormal_surfactant_physiolog1.28063980
50MP0009697_abnormal_copulation1.27529404
51MP0002128_abnormal_blood_circulation1.27358371
52MP0004883_abnormal_blood_vessel1.26473784
53MP0004085_abnormal_heartbeat1.26130288
54MP0003566_abnormal_cell_adhesion1.21947069
55MP0005620_abnormal_muscle_contractility1.21268422
56MP0002106_abnormal_muscle_physiology1.20591365
57MP0005164_abnormal_response_to1.18749771
58MP0002933_joint_inflammation1.18446281
59MP0000343_altered_response_to1.15828252
60* MP0010630_abnormal_cardiac_muscle1.12701271
61MP0000759_abnormal_skeletal_muscle1.11983368
62MP0003300_gastrointestinal_ulcer1.10576142
63MP0008438_abnormal_cutaneous_collagen1.09906920
64MP0002118_abnormal_lipid_homeostasis1.09652473
65MP0005332_abnormal_amino_acid1.08478379
66MP0005369_muscle_phenotype1.08280041
67MP0000747_muscle_weakness1.06740945
68MP0000230_abnormal_systemic_arterial1.05411799
69MP0005666_abnormal_adipose_tissue1.02540672
70MP0009379_abnormal_foot_pigmentation1.02494773
71MP0003950_abnormal_plasma_membrane0.99193222
72* MP0002925_abnormal_cardiovascular_devel0.98722825
73* MP0001614_abnormal_blood_vessel0.98649068
74MP0000609_abnormal_liver_physiology0.96604714
75MP0006054_spinal_hemorrhage0.95851412
76MP0004087_abnormal_muscle_fiber0.95642602
77MP0005083_abnormal_biliary_tract0.94839416
78MP0002168_other_aberrant_phenotype0.94603715
79MP0005503_abnormal_tendon_morphology0.93839929
80MP0000749_muscle_degeneration0.93052716
81MP0003091_abnormal_cell_migration0.91947671
82MP0004233_abnormal_muscle_weight0.91698146
83MP0009278_abnormal_bone_marrow0.91501553
84MP0009764_decreased_sensitivity_to0.90274470
85MP0005319_abnormal_enzyme/_coenzyme0.89639209
86MP0005388_respiratory_system_phenotype0.89058435
87MP0002133_abnormal_respiratory_system0.89058435
88MP0009643_abnormal_urine_homeostasis0.88978830
89MP0001661_extended_life_span0.88934318
90MP0002877_abnormal_melanocyte_morpholog0.87903639
91MP0002269_muscular_atrophy0.86457132
92MP0003303_peritoneal_inflammation0.84024401
93MP0010030_abnormal_orbit_morphology0.83267674
94MP0005023_abnormal_wound_healing0.81346813
95MP0001756_abnormal_urination0.80987262
96MP0000750_abnormal_muscle_regeneration0.80729859
97MP0000733_abnormal_muscle_development0.80541562
98MP0003868_abnormal_feces_composition0.80388427
99MP0005375_adipose_tissue_phenotype0.79454834
100MP0003690_abnormal_glial_cell0.78898151
101MP0004185_abnormal_adipocyte_glucose0.78496041
102MP0004510_myositis0.76988035
103MP0003045_fibrosis0.75322752
104* MP0000266_abnormal_heart_morphology0.74688291
105MP0003137_abnormal_impulse_conducting0.71103733
106MP0003943_abnormal_hepatobiliary_system0.71069757
107MP0008961_abnormal_basal_metabolism0.70817881
108MP0005647_abnormal_sex_gland0.68698070
109MP0000003_abnormal_adipose_tissue0.68044616
110MP0002971_abnormal_brown_adipose0.68020143
111MP0003075_altered_response_to0.66549835
112MP0009780_abnormal_chondrocyte_physiolo0.66228861
113MP0001666_abnormal_nutrient_absorption0.66218241
114MP0005275_abnormal_skin_tensile0.65865211
115MP0001915_intracranial_hemorrhage0.65469819
116MP0010352_gastrointestinal_tract_polyps0.64898117
117MP0003806_abnormal_nucleotide_metabolis0.63905127
118MP0005187_abnormal_penis_morphology0.62274533
119MP0001784_abnormal_fluid_regulation0.62265707
120MP0002108_abnormal_muscle_morphology0.61478906
121MP0002896_abnormal_bone_mineralization0.61013491
122MP0009115_abnormal_fat_cell0.58799723
123MP0001851_eye_inflammation0.58389824
124MP0001501_abnormal_sleep_pattern0.58189559
125MP0005166_decreased_susceptibility_to0.55967300
126MP0002638_abnormal_pupillary_reflex0.53652213
127MP0003941_abnormal_skin_development0.52803228
128MP0003948_abnormal_gas_homeostasis0.49235113
129MP0003633_abnormal_nervous_system0.48074044

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.02862011
2Esophageal varix (HP:0002040)5.45597975
3Deep venous thrombosis (HP:0002625)5.08070293
4Spontaneous hematomas (HP:0007420)4.46280398
5Hematochezia (HP:0002573)4.43079914
6Hypoglycemic coma (HP:0001325)4.26873020
7Muscle fiber inclusion bodies (HP:0100299)3.79810354
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.74742745
9Cerebral hemorrhage (HP:0001342)3.69634735
10Protrusio acetabuli (HP:0003179)3.65955089
11Nemaline bodies (HP:0003798)3.60081566
12Adactyly (HP:0009776)3.58122852
13Wrist flexion contracture (HP:0001239)3.47923019
14Muscle fiber splitting (HP:0003555)3.43368786
15Intrahepatic cholestasis (HP:0001406)3.39374476
16Joint hemorrhage (HP:0005261)3.38070073
17Hemorrhage of the eye (HP:0011885)3.33290789
18Complement deficiency (HP:0004431)3.32686510
19Type 1 muscle fiber predominance (HP:0003803)3.32109990
20Arterial tortuosity (HP:0005116)3.30367503
21Absent hand (HP:0004050)3.25964497
22Hyperlipoproteinemia (HP:0010980)3.25297903
23Lymphangioma (HP:0100764)3.22944391
24Portal hypertension (HP:0001409)3.22920703
25Xanthomatosis (HP:0000991)3.18156720
26Vascular tortuosity (HP:0004948)3.16555534
27Conjunctival telangiectasia (HP:0000524)3.14383571
28Interstitial pulmonary disease (HP:0006530)3.13164267
29Visceral angiomatosis (HP:0100761)3.10880108
30Cerebral aneurysm (HP:0004944)3.09789559
31Increased connective tissue (HP:0009025)3.07286944
32Spinal rigidity (HP:0003306)3.05048365
33Sudden death (HP:0001699)3.04768081
34Hypoglycemic seizures (HP:0002173)3.04581606
35Hyporeflexia of lower limbs (HP:0002600)3.04258296
36Hyperinsulinemic hypoglycemia (HP:0000825)3.03710573
37Aortic dissection (HP:0002647)3.02658277
38Ventricular tachycardia (HP:0004756)3.01203205
39Bundle branch block (HP:0011710)2.99699613
40Broad metatarsal (HP:0001783)2.96719945
41Hemangiomatosis (HP:0007461)2.94182435
42Abnormal atrioventricular conduction (HP:0005150)2.92797856
43Prolonged partial thromboplastin time (HP:0003645)2.91869474
44Heart block (HP:0012722)2.88045205
45Abnormality of the hepatic vasculature (HP:0006707)2.87858605
46EMG: myopathic abnormalities (HP:0003458)2.86441822
47Abnormality of the intrinsic pathway (HP:0010989)2.81294353
48Hypoalphalipoproteinemia (HP:0003233)2.81109707
49Abnormality of the nasal mucosa (HP:0000433)2.79741042
50Abnormality of the calf musculature (HP:0001430)2.74722679
51Abnormality of skeletal muscle fiber size (HP:0012084)2.73290008
52Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73261041
53Ketosis (HP:0001946)2.72275860
54Right ventricular cardiomyopathy (HP:0011663)2.71290484
55Distal lower limb muscle weakness (HP:0009053)2.71186942
56Asymmetric septal hypertrophy (HP:0001670)2.65026507
57Ketoacidosis (HP:0001993)2.65022363
58Nonimmune hydrops fetalis (HP:0001790)2.62960879
59Difficulty running (HP:0009046)2.62482241
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56523955
61Pancreatic islet-cell hyperplasia (HP:0004510)2.56053351
62Atrial fibrillation (HP:0005110)2.55730885
63Delayed CNS myelination (HP:0002188)2.52641757
64Exercise-induced muscle cramps (HP:0003710)2.52565041
65Round ear (HP:0100830)2.50495722
66Distal arthrogryposis (HP:0005684)2.49814557
67Cavernous hemangioma (HP:0001048)2.47495277
68Stroke (HP:0001297)2.47106758
69Overgrowth (HP:0001548)2.46266849
70Neck muscle weakness (HP:0000467)2.45821423
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45226506
72Abnormality of the common coagulation pathway (HP:0010990)2.44804632
73Porencephaly (HP:0002132)2.44665674
74Difficulty climbing stairs (HP:0003551)2.43788587
75Aneurysm (HP:0002617)2.42891994
76Hyperammonemia (HP:0001987)2.41040388
77Hip contracture (HP:0003273)2.39942354
78Muscle hypertrophy of the lower extremities (HP:0008968)2.38525588
79Pigmentary retinal degeneration (HP:0001146)2.38253554
80Skull defect (HP:0001362)2.37777697
81Supraventricular arrhythmia (HP:0005115)2.37713159
82Facial shape deformation (HP:0011334)2.35343340
83Potter facies (HP:0002009)2.35343340
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34347670
85Calf muscle hypertrophy (HP:0008981)2.32000000
86Limited hip movement (HP:0008800)2.31206866
87Lipoatrophy (HP:0100578)2.30898762
88Reduced subcutaneous adipose tissue (HP:0003758)2.30341599
89Primary atrial arrhythmia (HP:0001692)2.29825607
90Myocardial infarction (HP:0001658)2.28130930
91Hyperglycinuria (HP:0003108)2.26616993
92Pulmonary artery stenosis (HP:0004415)2.26357857
93Centrally nucleated skeletal muscle fibers (HP:0003687)2.26062816
94Growth hormone excess (HP:0000845)2.25213827
95Hyperkalemia (HP:0002153)2.23825517
96Hypolipoproteinemia (HP:0010981)2.20242561
97Aortic aneurysm (HP:0004942)2.19731473
98Distal lower limb amyotrophy (HP:0008944)2.19348335
99Venous insufficiency (HP:0005293)2.19336636
100Areflexia of lower limbs (HP:0002522)2.14851188
101Acanthosis nigricans (HP:0000956)2.14433028
102Abnormality of complement system (HP:0005339)2.14186494
103Pulmonary hypertension (HP:0002092)2.13737706
104Supraventricular tachycardia (HP:0004755)2.12972243
105Mitral valve prolapse (HP:0001634)2.12029615
106Short chin (HP:0000331)2.11354406
107Striae distensae (HP:0001065)2.11327757
108Abnormality of glycine metabolism (HP:0010895)2.06383803
109Abnormality of serine family amino acid metabolism (HP:0010894)2.06383803
110Mildly elevated creatine phosphokinase (HP:0008180)2.06246459
111Hemiplegia (HP:0002301)2.06181695
112Epidermoid cyst (HP:0200040)2.05983859
113Aortic valve stenosis (HP:0001650)2.05928801
114Hypercholesterolemia (HP:0003124)2.05696163
115Abnormality of fatty-acid metabolism (HP:0004359)2.05468927
116Mesangial abnormality (HP:0001966)2.05451925
117Nephritis (HP:0000123)2.03329694
118Cardiovascular calcification (HP:0011915)2.02111237
119Pulmonary embolism (HP:0002204)2.02065477
120Premature rupture of membranes (HP:0001788)1.98837607
121Frequent falls (HP:0002359)1.98593307
122Increased variability in muscle fiber diameter (HP:0003557)1.98532027
123Venous abnormality (HP:0002624)1.98265321
124Myoglobinuria (HP:0002913)1.97137215
125Decreased circulating renin level (HP:0003351)1.96756793
126Scapular winging (HP:0003691)1.94047200
127Hypoplasia of the iris (HP:0007676)1.94023353
128Mucosal telangiectasiae (HP:0100579)1.93594454
129Neonatal death (HP:0003811)1.93061596
130Menorrhagia (HP:0000132)1.92743175
131Atrioventricular block (HP:0001678)1.92639995
132Muscular dystrophy (HP:0003560)1.92324976
133Vascular calcification (HP:0004934)1.91864949
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89769231
135Tetraparesis (HP:0002273)1.89337797
136Dilated cardiomyopathy (HP:0001644)1.89183011
137Shallow orbits (HP:0000586)1.87709998
138Exercise-induced myalgia (HP:0003738)1.87670084
139Mitral stenosis (HP:0001718)1.86991893
140Myotonia (HP:0002486)1.86416401
141Hepatocellular carcinoma (HP:0001402)1.86323927
142Abnormality of the right ventricle (HP:0001707)1.86169770
143Symptomatic seizures (HP:0011145)1.85914461
144Syncope (HP:0001279)1.85807738
145Wormian bones (HP:0002645)1.84500723
146Hyperglycinemia (HP:0002154)1.84200062
147Skin nodule (HP:0200036)1.83922574
148Thrombophlebitis (HP:0004418)1.83584478
149Lower limb amyotrophy (HP:0007210)1.78131374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.78652574
2KDR6.41211945
3TGFBR23.79943643
4INSRR2.62236121
5RIPK12.48107224
6PTK2B2.02841820
7TGFBR12.01566499
8PDK21.85887378
9EPHB21.79365143
10BCKDK1.67648689
11MYLK1.67527536
12TRPM71.66017370
13GRK11.45338364
14TTN1.40850895
15FGFR41.34418668
16DMPK1.24693075
17ERN11.23298895
18CAMK1D1.22261126
19PDGFRA1.20161597
20FER1.19998462
21EEF2K1.14113845
22MAPKAPK31.14027977
23MAPK151.12933924
24EPHB11.10007728
25NTRK11.09187684
26FGFR21.07944735
27CAMK1G1.07638568
28PRKG21.06873979
29MAPK121.05186570
30PTK61.03914102
31SIK11.03013604
32BMPR1B1.02432082
33TRIB31.01205724
34PRKD10.99067582
35PRKAA20.98397748
36AKT30.95826833
37MAP2K30.92583392
38OBSCN0.89695781
39SGK20.85768095
40MST1R0.84997733
41PRKCH0.83158524
42LATS10.81880418
43MAP3K30.80569053
44MAPK70.78554063
45FGFR30.77676472
46CSK0.73142327
47LMTK20.71186763
48PHKG10.68546229
49PHKG20.68546229
50PDPK10.67608573
51PIK3CG0.67428525
52PTK20.65945588
53FRK0.64847448
54SGK2230.64272760
55SGK4940.64272760
56PKN20.62385043
57GSK3A0.60836279
58NUAK10.60598225
59LATS20.60516389
60RPS6KA20.60410659
61PAK40.57417700
62MET0.57137505
63JAK10.57130107
64WNK40.56908939
65PDGFRB0.56720070
66NTRK30.56564128
67LRRK20.55764727
68MAP3K70.54622997
69CDC42BPA0.54104980
70IGF1R0.52779404
71OXSR10.51505969
72PRKD30.50698141
73DAPK20.50674183
74MAP3K130.50519189
75STK390.49009949
76MAP2K20.48751681
77PDK40.48412929
78PDK30.48412929
79ITK0.47913295
80PAK30.45533246
81FES0.45521904
82PRKAA10.45211803
83MAP3K60.45107944
84PIK3CA0.44786386
85MAP2K10.42341466
86MOS0.42001393
87PRKD20.41828426
88STK38L0.41581986
89CAMK40.41566465
90STK380.41347667
91EGFR0.40778919
92TEC0.40724412
93RET0.39784642
94BCR0.39757070
95PRKCE0.38279431
96JAK20.37063123
97ROCK20.36635902
98ZAP700.36250747
99NLK0.36045404
100DDR20.35927858
101INSR0.35555342
102SRC0.35120108
103MAPKAPK50.35021945
104PAK60.34949683
105ROCK10.33941475
106PINK10.33504412
107MARK20.32640698
108PAK20.31321180
109STK100.30876075
110TYK20.30770522
111CAMK10.30342464
112MAP3K10.30242105
113CAMK2A0.29806524
114CAMK2D0.29452275
115DAPK30.28899605
116NEK90.28841973
117MAP2K40.28170478
118TBK10.28016852
119PRKG10.27250448
120PDK10.27049088
121MARK10.27004338
122MAPK40.26912170
123MUSK0.26465422
124GRK70.25461881
125CAMK2B0.25057969
126SGK30.24295977
127PRKACG0.23509734
128MTOR0.23277626
129GRK50.22907209
130BMX0.22222274
131EPHA30.22107006
132ABL10.21574640
133PRKCQ0.20979375

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.06672697
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.80047086
3Arginine biosynthesis_Homo sapiens_hsa002202.78420031
4Fatty acid degradation_Homo sapiens_hsa000712.48276754
5Complement and coagulation cascades_Homo sapiens_hsa046102.44714507
6Propanoate metabolism_Homo sapiens_hsa006402.22773330
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22683141
8PPAR signaling pathway_Homo sapiens_hsa033202.22391878
9Bile secretion_Homo sapiens_hsa049762.11896592
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09454707
11Tryptophan metabolism_Homo sapiens_hsa003802.03640782
12Fatty acid metabolism_Homo sapiens_hsa012121.93389601
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75458002
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67252726
15ECM-receptor interaction_Homo sapiens_hsa045121.66758280
16Caffeine metabolism_Homo sapiens_hsa002321.59382810
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57642408
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.54638977
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51356117
20Butanoate metabolism_Homo sapiens_hsa006501.40106993
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39584950
22Focal adhesion_Homo sapiens_hsa045101.39212659
23Circadian rhythm_Homo sapiens_hsa047101.38265528
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34734907
25Staphylococcus aureus infection_Homo sapiens_hsa051501.34600168
26Dilated cardiomyopathy_Homo sapiens_hsa054141.32438326
27ABC transporters_Homo sapiens_hsa020101.31157064
28Vitamin digestion and absorption_Homo sapiens_hsa049771.23795211
29Peroxisome_Homo sapiens_hsa041461.22455743
30beta-Alanine metabolism_Homo sapiens_hsa004101.19013789
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16984609
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15392143
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14806277
34Oxytocin signaling pathway_Homo sapiens_hsa049211.13048892
35Fat digestion and absorption_Homo sapiens_hsa049751.09928108
36Dorso-ventral axis formation_Homo sapiens_hsa043201.09464655
37Fatty acid elongation_Homo sapiens_hsa000621.08265662
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05874335
39* Adherens junction_Homo sapiens_hsa045201.01263837
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00590681
41Fatty acid biosynthesis_Homo sapiens_hsa000610.99214905
42Insulin resistance_Homo sapiens_hsa049310.97704465
43TGF-beta signaling pathway_Homo sapiens_hsa043500.96619042
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94260770
45Histidine metabolism_Homo sapiens_hsa003400.94037649
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.93699114
47Phenylalanine metabolism_Homo sapiens_hsa003600.93218708
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91494066
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91158834
50Chemical carcinogenesis_Homo sapiens_hsa052040.90897335
51Calcium signaling pathway_Homo sapiens_hsa040200.90715627
52Circadian entrainment_Homo sapiens_hsa047130.90463124
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90389946
54Pyruvate metabolism_Homo sapiens_hsa006200.89855197
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.89817365
56Ovarian steroidogenesis_Homo sapiens_hsa049130.88812451
57GnRH signaling pathway_Homo sapiens_hsa049120.88044061
58Glutamatergic synapse_Homo sapiens_hsa047240.87417060
59Rap1 signaling pathway_Homo sapiens_hsa040150.86065087
60Retinol metabolism_Homo sapiens_hsa008300.85158394
61Amoebiasis_Homo sapiens_hsa051460.84379457
62Starch and sucrose metabolism_Homo sapiens_hsa005000.82925987
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82577620
64Morphine addiction_Homo sapiens_hsa050320.80865322
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.79729695
66Renin secretion_Homo sapiens_hsa049240.79665605
67Insulin secretion_Homo sapiens_hsa049110.79057252
68Lysine degradation_Homo sapiens_hsa003100.76227069
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76154508
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.75415479
71Serotonergic synapse_Homo sapiens_hsa047260.75207595
72Tyrosine metabolism_Homo sapiens_hsa003500.74327234
73Pertussis_Homo sapiens_hsa051330.73853309
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71449571
75Linoleic acid metabolism_Homo sapiens_hsa005910.71083516
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71000741
77Arginine and proline metabolism_Homo sapiens_hsa003300.70939885
78Protein digestion and absorption_Homo sapiens_hsa049740.70161717
79Glycerolipid metabolism_Homo sapiens_hsa005610.67741595
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67208574
81Platelet activation_Homo sapiens_hsa046110.65203736
82African trypanosomiasis_Homo sapiens_hsa051430.64833265
83Cardiac muscle contraction_Homo sapiens_hsa042600.64791230
84Small cell lung cancer_Homo sapiens_hsa052220.64317134
85Carbon metabolism_Homo sapiens_hsa012000.64008766
86Mineral absorption_Homo sapiens_hsa049780.62629261
87Axon guidance_Homo sapiens_hsa043600.62572988
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61987728
89Long-term potentiation_Homo sapiens_hsa047200.61470737
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60896369
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60746198
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60364953
93Tight junction_Homo sapiens_hsa045300.57944812
94Insulin signaling pathway_Homo sapiens_hsa049100.57821552
95Notch signaling pathway_Homo sapiens_hsa043300.56469723
96Thyroid hormone synthesis_Homo sapiens_hsa049180.56400851
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56357343
98Pathways in cancer_Homo sapiens_hsa052000.55942154
99GABAergic synapse_Homo sapiens_hsa047270.55507390
100Long-term depression_Homo sapiens_hsa047300.54890701
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54476033
102MAPK signaling pathway_Homo sapiens_hsa040100.53924960
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53251063
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53069800
105Taste transduction_Homo sapiens_hsa047420.52366705
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52291835
107Melanogenesis_Homo sapiens_hsa049160.52065194
108Proteoglycans in cancer_Homo sapiens_hsa052050.51083129
109Glucagon signaling pathway_Homo sapiens_hsa049220.49454018
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48474045
111Prion diseases_Homo sapiens_hsa050200.48214311
112Malaria_Homo sapiens_hsa051440.47960551
113Renal cell carcinoma_Homo sapiens_hsa052110.47376877
114HIF-1 signaling pathway_Homo sapiens_hsa040660.47222376
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46963946
116Cholinergic synapse_Homo sapiens_hsa047250.46664806
117Choline metabolism in cancer_Homo sapiens_hsa052310.46003456
118VEGF signaling pathway_Homo sapiens_hsa043700.45530413
119AMPK signaling pathway_Homo sapiens_hsa041520.45504021
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44912369
121Ras signaling pathway_Homo sapiens_hsa040140.41226012
122Sulfur metabolism_Homo sapiens_hsa009200.40504035
123cAMP signaling pathway_Homo sapiens_hsa040240.38857037
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38207442
125Selenocompound metabolism_Homo sapiens_hsa004500.37619857
126Gap junction_Homo sapiens_hsa045400.35439945
127Estrogen signaling pathway_Homo sapiens_hsa049150.35009899
128Gastric acid secretion_Homo sapiens_hsa049710.35007646
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34447105
130Salivary secretion_Homo sapiens_hsa049700.34074757
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32863687
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32789428
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.31523964
134Pancreatic secretion_Homo sapiens_hsa049720.31304852
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.30877600

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