PTPRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* positive regulation of gamma-delta T cell activation (GO:0046645)6.82331780
2* negative T cell selection (GO:0043383)6.32738670
3T cell migration (GO:0072678)5.82287676
4* negative thymic T cell selection (GO:0045060)5.81629253
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.78319791
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78319791
7* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.65312545
8* negative regulation of cell killing (GO:0031342)5.65312545
9interferon-gamma production (GO:0032609)5.56010312
10antigen processing and presentation of endogenous antigen (GO:0019883)5.49594489
11response to interleukin-15 (GO:0070672)5.48728770
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.47711353
13* positive thymic T cell selection (GO:0045059)5.37033532
14cellular response to interleukin-15 (GO:0071350)5.36117380
15* positive T cell selection (GO:0043368)5.30136615
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.18948549
17positive regulation by organism of defense response of other organism involved in symbiotic interact5.18948549
18modulation by symbiont of host immune response (GO:0052553)5.18948549
19positive regulation by symbiont of host defense response (GO:0052509)5.18948549
20modulation by symbiont of host defense response (GO:0052031)5.18948549
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.18948549
22* regulation of gamma-delta T cell differentiation (GO:0045586)5.17880910
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06558330
24leukocyte aggregation (GO:0070486)5.01799312
25* T cell selection (GO:0045058)4.92264572
26* thymic T cell selection (GO:0045061)4.84846147
27* regulation of isotype switching to IgG isotypes (GO:0048302)4.84714734
28* regulation of gamma-delta T cell activation (GO:0046643)4.83862694
29* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.83833734
30* regulation of B cell receptor signaling pathway (GO:0050855)4.70986380
31activated T cell proliferation (GO:0050798)4.58089634
32regulation of interleukin-12 biosynthetic process (GO:0045075)4.50761765
33detection of molecule of bacterial origin (GO:0032490)4.40870888
34macrophage activation involved in immune response (GO:0002281)4.40676309
35cellular extravasation (GO:0045123)4.33316258
36detection of other organism (GO:0098543)4.29361552
37T cell costimulation (GO:0031295)4.19445427
38neutrophil activation involved in immune response (GO:0002283)4.16970746
39microglial cell activation (GO:0001774)4.16757442
40lymphocyte costimulation (GO:0031294)4.12079799
41* T cell receptor signaling pathway (GO:0050852)4.11504415
42regulation of T cell tolerance induction (GO:0002664)4.07438059
43positive regulation of interleukin-2 production (GO:0032743)4.06220471
44regulation of interleukin-2 biosynthetic process (GO:0045076)4.02705980
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.02232140
46regulation of natural killer cell mediated immunity (GO:0002715)4.02232140
47detection of external biotic stimulus (GO:0098581)3.99375667
48* negative regulation of lymphocyte mediated immunity (GO:0002707)3.96498571
49regulation of interferon-beta biosynthetic process (GO:0045357)3.94773212
50* antigen receptor-mediated signaling pathway (GO:0050851)3.91783970
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91036655
52tolerance induction (GO:0002507)3.89250616
53detection of bacterium (GO:0016045)3.88952442
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.87414917
55positive regulation of natural killer cell mediated immunity (GO:0002717)3.87414917
56* positive regulation of isotype switching (GO:0045830)3.83650409
57* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.81448602
58* regulation of alpha-beta T cell proliferation (GO:0046640)3.77409417
59regulation of T cell receptor signaling pathway (GO:0050856)3.72823015
60* B cell receptor signaling pathway (GO:0050853)3.69889289
61mast cell activation (GO:0045576)3.67895276
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.64560414
63response to peptidoglycan (GO:0032494)3.62447843
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60885011
65response to host immune response (GO:0052572)3.60885011
66myeloid cell activation involved in immune response (GO:0002275)3.57222478
67macrophage activation (GO:0042116)3.55484058
68detection of biotic stimulus (GO:0009595)3.54613952
69* regulation of B cell differentiation (GO:0045577)3.54427923
70lymphocyte migration (GO:0072676)3.53244581
71respiratory burst (GO:0045730)3.51844523
72neutrophil mediated immunity (GO:0002446)3.50666127
73* negative regulation of leukocyte mediated immunity (GO:0002704)3.48955487
74natural killer cell activation (GO:0030101)3.48079098
75* positive regulation of immunoglobulin mediated immune response (GO:0002891)3.45427375
76* positive regulation of B cell mediated immunity (GO:0002714)3.45427375
77* positive regulation of DNA recombination (GO:0045911)3.45395064
78positive regulation of B cell differentiation (GO:0045579)3.43971563
79regulation of regulatory T cell differentiation (GO:0045589)3.42106911
80NIK/NF-kappaB signaling (GO:0038061)3.41357585
81* leukocyte cell-cell adhesion (GO:0007159)3.36144744
82myeloid dendritic cell activation (GO:0001773)3.35824496
83response to host (GO:0075136)3.35344499
84response to host defenses (GO:0052200)3.35344499
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.35344499
86alpha-beta T cell activation (GO:0046631)3.32460631
87granulocyte activation (GO:0036230)3.28627198
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27106461
89positive regulation of tolerance induction (GO:0002645)3.24836590
90* regulation of isotype switching (GO:0045191)3.24277077
91* positive regulation of alpha-beta T cell proliferation (GO:0046641)3.22860485
92negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.22574790
93regulation of response to interferon-gamma (GO:0060330)3.22123160
94myeloid leukocyte mediated immunity (GO:0002444)3.20895348
95interferon-gamma-mediated signaling pathway (GO:0060333)3.19811420
96dendritic cell migration (GO:0036336)3.19080423
97response to type I interferon (GO:0034340)3.19024430
98regulation of tolerance induction (GO:0002643)3.15195929
99production of molecular mediator involved in inflammatory response (GO:0002532)3.15010367
100regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.14660636
101* regulation of immunoglobulin mediated immune response (GO:0002889)3.14433183
102* regulation of B cell mediated immunity (GO:0002712)3.12317575
103T cell homeostasis (GO:0043029)3.12074482
104cellular response to type I interferon (GO:0071357)3.11688494
105type I interferon signaling pathway (GO:0060337)3.11688494
106alpha-beta T cell differentiation (GO:0046632)3.10538284
107* regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08880861
108hepatocyte apoptotic process (GO:0097284)3.08549626
109regulation of interleukin-2 production (GO:0032663)3.08006265
110* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07527105
111* T cell proliferation (GO:0042098)3.06036629
112leukocyte degranulation (GO:0043299)3.05634368
113* negative regulation of T cell mediated immunity (GO:0002710)3.05433078
114dendritic cell chemotaxis (GO:0002407)3.04782382
115* T cell differentiation (GO:0030217)3.04681767
116response to muramyl dipeptide (GO:0032495)3.03257635
117regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01781472
118positive regulation of mast cell activation (GO:0033005)3.01640249
119negative regulation of B cell proliferation (GO:0030889)3.01560217
120response to protozoan (GO:0001562)3.00615694
121JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.99872689
122positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98821367
123mature B cell differentiation (GO:0002335)2.98487336
124* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.98001265
125defense response to protozoan (GO:0042832)2.97649385
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97317225
127negative regulation of T-helper cell differentiation (GO:0045623)2.97317225
128neutrophil activation (GO:0042119)2.96741419
129lymphocyte homeostasis (GO:0002260)2.95717070
130cellular defense response (GO:0006968)2.94633263
131myeloid dendritic cell differentiation (GO:0043011)2.93489330
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93289862
133* regulation of cell killing (GO:0031341)2.92661084
134negative regulation of interleukin-12 production (GO:0032695)2.91624382
135* negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91452862
136positive regulation of interferon-alpha production (GO:0032727)2.90444294
137* regulation of T cell mediated cytotoxicity (GO:0001914)2.90177390
138* T cell activation (GO:0042110)2.89431907
139negative regulation of T cell receptor signaling pathway (GO:0050860)2.89299567
140* positive regulation of immunoglobulin production (GO:0002639)2.88336400
141regulation of mast cell degranulation (GO:0043304)2.87311631
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84873948
143antigen processing and presentation via MHC class Ib (GO:0002475)2.84656489
144* regulation of lymphocyte mediated immunity (GO:0002706)2.82989976
145* positive regulation of lymphocyte mediated immunity (GO:0002708)2.81796696
146positive regulation of granulocyte differentiation (GO:0030854)2.79456976
147immunoglobulin mediated immune response (GO:0016064)2.79377206
148* positive regulation of B cell activation (GO:0050871)2.78803554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.24220733
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.83694945
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.14804064
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.21903828
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.80894327
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.80177283
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.49047166
8* RUNX_20019798_ChIP-Seq_JUKART_Human3.46974609
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45926650
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.39153812
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.26423544
12E2F7_22180533_ChIP-Seq_HELA_Human3.17554189
13* MYB_26560356_Chip-Seq_TH2_Human3.11081236
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.07011767
15MYC_22102868_ChIP-Seq_BL_Human3.05551227
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.94105346
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.93641887
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.76848121
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76732073
20MAF_26560356_Chip-Seq_TH1_Human2.68070123
21* MYB_26560356_Chip-Seq_TH1_Human2.63210565
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58361181
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45519847
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38729617
25UTX_26944678_Chip-Seq_JUKART_Human2.36606876
26VDR_21846776_ChIP-Seq_THP-1_Human2.25021869
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23965241
28* SPI1_23547873_ChIP-Seq_NB4_Human2.15656290
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13931691
30SCL_19346495_ChIP-Seq_HPC-7_Human2.13801739
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.10435462
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.04551259
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99201195
34* GATA3_27048872_Chip-Seq_THYMUS_Human1.94187557
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92702520
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90432029
37* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87540816
38VDR_24763502_ChIP-Seq_THP-1_Human1.86674346
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.81791946
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77115787
41MAF_26560356_Chip-Seq_TH2_Human1.74812075
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73768926
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67295491
44SPI1_23127762_ChIP-Seq_K562_Human1.63336625
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61974161
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61322342
47* PU_27001747_Chip-Seq_BMDM_Mouse1.50543785
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46426743
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43809707
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41979137
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40938183
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39445605
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.38399634
54KDM2B_26808549_Chip-Seq_DND41_Human1.37202019
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36389317
56* GATA3_26560356_Chip-Seq_TH2_Human1.36299412
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36193479
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35678310
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33324876
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29405954
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28390275
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23639864
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21776026
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16383848
65CIITA_25753668_ChIP-Seq_RAJI_Human1.13952677
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07513126
67GATA1_19941826_ChIP-Seq_K562_Human1.06238622
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05390743
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05119541
70* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04722348
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02250100
72FOXM1_23109430_ChIP-Seq_U2OS_Human0.99149402
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98836474
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98227417
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95941180
76ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95078915
77PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95003668
78VDR_24787735_ChIP-Seq_THP-1_Human0.94733474
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92292647
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92278465
81SMRT_27268052_Chip-Seq_Bcells_Human0.92005505
82* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91883297
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91558871
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.90674995
85* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90373612
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88810142
87* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88299456
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87853744
89GATA1_22025678_ChIP-Seq_K562_Human0.87368210
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.84795197
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.82461101
92VDR_23849224_ChIP-Seq_CD4+_Human0.82418086
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81513248
94* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80350596
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78521319
96* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78158981
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.77192836
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72237788
99* NCOR1_26117541_ChIP-Seq_K562_Human0.71240890
100ELK1_19687146_ChIP-ChIP_HELA_Human0.69565716
101FOXP3_21729870_ChIP-Seq_TREG_Human0.68991037
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68811550
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67204751
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67146617
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66411184
106RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66362588
107ETS1_22383799_ChIP-Seq_G1ME_Mouse0.65675236
108SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.64469572
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.63772203
110* GATA2_19941826_ChIP-Seq_K562_Human0.62128037
111GATA3_26560356_Chip-Seq_TH1_Human0.61805348
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.60708205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.31969552
2* MP0003763_abnormal_thymus_physiology4.08783806
3MP0001835_abnormal_antigen_presentation4.07451112
4MP0000685_abnormal_immune_system3.59092273
5* MP0001800_abnormal_humoral_immune3.37279227
6MP0009785_altered_susceptibility_to3.23402651
7MP0001790_abnormal_immune_system3.22453429
8MP0005387_immune_system_phenotype3.22453429
9MP0006082_CNS_inflammation3.16765337
10* MP0005000_abnormal_immune_tolerance3.13047072
11* MP0002723_abnormal_immune_serum2.93886546
12MP0003436_decreased_susceptibility_to2.93152694
13* MP0002420_abnormal_adaptive_immunity2.89358844
14* MP0002452_abnormal_antigen_presenting2.87153781
15* MP0001819_abnormal_immune_cell2.86260433
16* MP0005025_abnormal_response_to2.70703710
17* MP0002398_abnormal_bone_marrow2.66002359
18MP0002166_altered_tumor_susceptibility2.64433422
19* MP0002405_respiratory_system_inflammati2.50715001
20MP0003303_peritoneal_inflammation2.42212237
21* MP0000716_abnormal_immune_system2.40002698
22* MP0002419_abnormal_innate_immunity2.39055780
23MP0002006_tumorigenesis2.34461983
24MP0009333_abnormal_splenocyte_physiolog2.32150736
25* MP0002148_abnormal_hypersensitivity_rea2.30655287
26MP0002396_abnormal_hematopoietic_system2.27044613
27MP0008260_abnormal_autophagy2.17767324
28* MP0000689_abnormal_spleen_morphology2.16356589
29* MP0000703_abnormal_thymus_morphology2.13734296
30* MP0002722_abnormal_immune_system2.11366619
31MP0001873_stomach_inflammation2.11116779
32MP0003300_gastrointestinal_ulcer2.10551079
33MP0010155_abnormal_intestine_physiology2.10242388
34MP0004947_skin_inflammation2.04535717
35MP0003724_increased_susceptibility_to1.98630354
36* MP0002429_abnormal_blood_cell1.94995678
37MP0005464_abnormal_platelet_physiology1.92949157
38MP0001853_heart_inflammation1.82208445
39* MP0001845_abnormal_inflammatory_respons1.81906846
40MP0000858_altered_metastatic_potential1.74564980
41MP0004510_myositis1.66614105
42MP0002933_joint_inflammation1.62560312
43MP0004808_abnormal_hematopoietic_stem1.56288781
44MP0005451_abnormal_body_composition1.53463094
45MP0004883_abnormal_blood_vessel1.52076969
46MP0003448_altered_tumor_morphology1.49901019
47* MP0003866_abnormal_defecation1.42323717
48MP0000569_abnormal_digit_pigmentation1.42282337
49MP0002132_abnormal_respiratory_system1.41997776
50MP0001533_abnormal_skeleton_physiology1.32573891
51MP0000465_gastrointestinal_hemorrhage1.32237747
52MP0008469_abnormal_protein_level1.29823320
53MP0005310_abnormal_salivary_gland1.27334361
54MP0005397_hematopoietic_system_phenotyp1.26450310
55MP0001545_abnormal_hematopoietic_system1.26450310
56MP0005174_abnormal_tail_pigmentation1.22405644
57MP0009278_abnormal_bone_marrow1.17534636
58MP0001851_eye_inflammation1.16765526
59MP0003656_abnormal_erythrocyte_physiolo1.15470090
60MP0003045_fibrosis1.14754457
61MP0008057_abnormal_DNA_replication1.14092106
62MP0003172_abnormal_lysosome_physiology1.12412291
63MP0003690_abnormal_glial_cell1.07481209
64MP0003787_abnormal_imprinting1.05379065
65MP0005164_abnormal_response_to1.03819605
66MP0004381_abnormal_hair_follicle1.02174891
67* MP0002019_abnormal_tumor_incidence1.01222764
68MP0005075_abnormal_melanosome_morpholog0.99975570
69MP0000490_abnormal_crypts_of0.99161209
70MP0000015_abnormal_ear_pigmentation0.99112775
71MP0010352_gastrointestinal_tract_polyps0.98095735
72* MP0002998_abnormal_bone_remodeling0.94683914
73MP0009764_decreased_sensitivity_to0.94090581
74MP0005166_decreased_susceptibility_to0.92738879
75MP0004130_abnormal_muscle_cell0.88739842
76MP0002009_preneoplasia0.85985881
77MP0005058_abnormal_lysosome_morphology0.85457874
78MP0003221_abnormal_cardiomyocyte_apopto0.85393841
79MP0003075_altered_response_to0.78077683
80MP0009763_increased_sensitivity_to0.75677312
81MP0010307_abnormal_tumor_latency0.74460314
82MP0005076_abnormal_cell_differentiation0.71492472
83MP0002138_abnormal_hepatobiliary_system0.69876977
84MP0003183_abnormal_peptide_metabolism0.69736057
85MP0005023_abnormal_wound_healing0.65925310
86MP0004484_altered_response_of0.64857268
87MP0000371_diluted_coat_color0.63709979
88MP0003077_abnormal_cell_cycle0.63245465
89MP0003453_abnormal_keratinocyte_physiol0.60118683
90MP0001986_abnormal_taste_sensitivity0.59555126
91MP0003091_abnormal_cell_migration0.58841145
92* MP0002136_abnormal_kidney_physiology0.58168566
93MP0003693_abnormal_embryo_hatching0.57049816
94MP0002095_abnormal_skin_pigmentation0.56677215
95MP0002332_abnormal_exercise_endurance0.55936735
96MP0009765_abnormal_xenobiotic_induced0.54737838
97MP0008874_decreased_physiological_sensi0.54389367
98MP0001663_abnormal_digestive_system0.53416873
99MP0001191_abnormal_skin_condition0.53052233
100MP0003828_pulmonary_edema0.52608582
101MP0008961_abnormal_basal_metabolism0.52328252
102MP0000604_amyloidosis0.51381627
103MP0003566_abnormal_cell_adhesion0.50619062
104MP0000249_abnormal_blood_vessel0.50171477
105MP0000343_altered_response_to0.49917846
106* MP0003795_abnormal_bone_structure0.49860931
107MP0005376_homeostasis/metabolism_phenot0.49725678
108MP0005390_skeleton_phenotype0.49609589
109MP0008877_abnormal_DNA_methylation0.49478652
110MP0010094_abnormal_chromosome_stability0.48209286
111MP0003252_abnormal_bile_duct0.48065942
112MP0002133_abnormal_respiratory_system0.46798857
113MP0002277_abnormal_respiratory_mucosa0.44930607
114* MP0000609_abnormal_liver_physiology0.44299705
115MP0000313_abnormal_cell_death0.44232808
116MP0003191_abnormal_cellular_cholesterol0.43395641
117MP0008058_abnormal_DNA_repair0.43069156
118MP0001243_abnormal_dermal_layer0.40223060

Predicted human phenotypes

RankGene SetZ-score
1* T lymphocytopenia (HP:0005403)6.01954199
2* Abnormality of T cell number (HP:0011839)5.83684572
3Eczematoid dermatitis (HP:0000976)4.83082287
4Recurrent viral infections (HP:0004429)4.79916469
5Recurrent fungal infections (HP:0002841)4.76014948
6Severe combined immunodeficiency (HP:0004430)4.75082917
7Recurrent abscess formation (HP:0002722)4.70681898
8Combined immunodeficiency (HP:0005387)4.46547539
9Elevated erythrocyte sedimentation rate (HP:0003565)4.37879533
10Stomatitis (HP:0010280)4.35634980
11Myositis (HP:0100614)4.29904011
12Recurrent bronchitis (HP:0002837)4.27933787
13* Abnormality of T cells (HP:0002843)4.27433729
14Panhypogammaglobulinemia (HP:0003139)4.24513137
15Nasal polyposis (HP:0100582)4.20482589
16Thyroiditis (HP:0100646)4.11776347
17Recurrent bacterial skin infections (HP:0005406)4.02981696
18Chronic mucocutaneous candidiasis (HP:0002728)3.98300244
19Recurrent cutaneous fungal infections (HP:0011370)3.98300244
20Chronic otitis media (HP:0000389)3.82296106
21Retrobulbar optic neuritis (HP:0100654)3.80076920
22Optic neuritis (HP:0100653)3.80076920
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.78769466
24Mediastinal lymphadenopathy (HP:0100721)3.78538408
25IgM deficiency (HP:0002850)3.75684465
26IgG deficiency (HP:0004315)3.59988439
27Meningitis (HP:0001287)3.57710118
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.55244564
29Abnormality of the nasal mucosa (HP:0000433)3.52690451
30Vasculitis (HP:0002633)3.50688929
31Abnormality of eosinophils (HP:0001879)3.50488584
32Orchitis (HP:0100796)3.47321561
33Autoimmune thrombocytopenia (HP:0001973)3.43481034
34Abnormality of the fingertips (HP:0001211)3.42084998
35Pustule (HP:0200039)3.40952423
36Abnormality of B cell number (HP:0010975)3.38907056
37B lymphocytopenia (HP:0010976)3.38907056
38Leukocytosis (HP:0001974)3.37752210
39Recurrent skin infections (HP:0001581)3.34993392
40Eosinophilia (HP:0001880)3.31520905
41Agammaglobulinemia (HP:0004432)3.25192817
42Lymphopenia (HP:0001888)3.19779532
43Inflammation of the large intestine (HP:0002037)3.15900129
44Chronic diarrhea (HP:0002028)3.12884572
45Obstructive lung disease (HP:0006536)3.12349158
46Chronic obstructive pulmonary disease (HP:0006510)3.12349158
47Abnormality of cells of the lymphoid lineage (HP:0012140)3.10465176
48Pulmonary infiltrates (HP:0002113)3.04991191
49Gastrointestinal inflammation (HP:0004386)3.01326683
50Hypoplasia of the thymus (HP:0000778)2.95077281
51Encephalitis (HP:0002383)2.92436555
52Joint swelling (HP:0001386)2.90342115
53Abnormality of T cell physiology (HP:0011840)2.90111308
54Granulocytopenia (HP:0001913)2.88771948
55Arterial thrombosis (HP:0004420)2.87584093
56Urticaria (HP:0001025)2.87205018
57Hemoptysis (HP:0002105)2.85688029
58Recurrent gram-negative bacterial infections (HP:0005420)2.84434935
59IgA deficiency (HP:0002720)2.83975552
60Colitis (HP:0002583)2.81174545
61Gastrointestinal infarctions (HP:0005244)2.80778812
62Spontaneous hematomas (HP:0007420)2.77784774
63Thrombocytosis (HP:0001894)2.77436558
64Increased IgM level (HP:0003496)2.76067494
65Recurrent sinusitis (HP:0011108)2.72361136
66Abnormality of macrophages (HP:0004311)2.69958176
67Autoimmune hemolytic anemia (HP:0001890)2.66140394
68Keratoconjunctivitis sicca (HP:0001097)2.65993272
69Periodontitis (HP:0000704)2.65265407
70Lymphoma (HP:0002665)2.64013075
71Abnormality of the prostate (HP:0008775)2.54178209
72Gingivitis (HP:0000230)2.54129549
73Peritonitis (HP:0002586)2.53060826
74Gastrointestinal stroma tumor (HP:0100723)2.52593352
75Cellulitis (HP:0100658)2.51651463
76Increased IgE level (HP:0003212)2.42437674
77Keratoconjunctivitis (HP:0001096)2.40279182
78Slow saccadic eye movements (HP:0000514)2.38807922
79Chest pain (HP:0100749)2.36064479
80Abnormality of the pleura (HP:0002103)2.34930504
81Viral hepatitis (HP:0006562)2.32542600
82Bronchitis (HP:0012387)2.31799193
83Epistaxis (HP:0000421)2.30052273
84Prolonged bleeding time (HP:0003010)2.29873267
85Verrucae (HP:0200043)2.29508642
86Papilloma (HP:0012740)2.29508642
87Acute hepatic failure (HP:0006554)2.25836985
88Episodic fever (HP:0001954)2.24914955
89Gingival bleeding (HP:0000225)2.22480346
90Chronic sinusitis (HP:0011109)2.22449679
91Papilledema (HP:0001085)2.20497869
92Hypergammaglobulinemia (HP:0010702)2.19555529
93Glomerulopathy (HP:0100820)2.16726807
94Hypochromic anemia (HP:0001931)2.16147841
95Emphysema (HP:0002097)2.15390064
96Abnormal platelet volume (HP:0011876)2.12127206
97Subacute progressive viral hepatitis (HP:0006572)2.11946523
98Pulmonary embolism (HP:0002204)2.11754673
99Abnormality of the peritoneum (HP:0002585)2.10292790
100Keratitis (HP:0000491)2.07055409
101Abnormality of the endocardium (HP:0004306)2.03147800
102Amaurosis fugax (HP:0100576)2.01615194
103Stomach cancer (HP:0012126)2.01541075
104Cheilitis (HP:0100825)1.98246609
105Vertigo (HP:0002321)1.97784875
106Microcytic anemia (HP:0001935)1.93845898
107Sepsis (HP:0100806)1.93139764
108Hypochromic microcytic anemia (HP:0004840)1.92586349
109Restrictive lung disease (HP:0002091)1.92528598
110Skin ulcer (HP:0200042)1.91997107
111Neoplasm of the tracheobronchial system (HP:0100552)1.90767488
112Polyneuropathy (HP:0001271)1.89943887
113Osteomyelitis (HP:0002754)1.86955177
114Gangrene (HP:0100758)1.86254638
115Arthralgia (HP:0002829)1.86174856
116Prostate neoplasm (HP:0100787)1.82128968
117Fatigue (HP:0012378)1.80966533
118Interstitial pulmonary disease (HP:0006530)1.80869987
119Hematochezia (HP:0002573)1.80254986
120Anorexia (HP:0002039)1.79372168
121Hepatitis (HP:0012115)1.77319428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.49471580
2TXK5.24159574
3ITK3.31340800
4JAK33.30051455
5MAP3K142.99568695
6TYK22.95724209
7ZAP702.63477830
8JAK12.55454641
9STK102.50926046
10IKBKE2.45139141
11FGFR42.17138410
12PRPF4B2.04432491
13IRAK41.96085172
14BLK1.95245328
15GRK61.90057871
16FGFR31.86863825
17LCK1.84736370
18TBK11.83648734
19TEC1.82810582
20MAP3K131.80318118
21SYK1.75753273
22BTK1.74727003
23KIT1.61612636
24HCK1.61291956
25NLK1.61090298
26IKBKB1.59874149
27RIPK41.52470124
28* CSK1.42547437
29MAP3K101.41136992
30BMPR21.35422718
31MARK31.32073760
32MST41.30751877
33PIK3CG1.29692733
34PRKCQ1.25968604
35CDK121.24244083
36CAMKK21.20487099
37CHUK1.15071555
38PIM11.14443797
39TGFBR21.13124492
40SIK21.10602335
41MAP3K11.09013122
42CSF1R1.07095520
43LRRK21.06854947
44EEF2K1.05702214
45LYN1.05527564
46CLK11.04947718
47IRAK31.02615599
48FES1.02045527
49MAP3K31.00958679
50JAK20.98867115
51RPS6KA40.97943961
52MAP3K20.96653372
53PRKCH0.96117130
54KSR20.91404330
55MATK0.89942707
56NME20.84209468
57MAP2K30.80030638
58EPHB10.77499890
59IRAK20.77456842
60MELK0.77047258
61CAMKK10.75657634
62MAP3K110.74402030
63TTN0.73320365
64NEK90.72976668
65MAP3K70.72588486
66WNK10.71724161
67BRD40.71505404
68SGK20.69221831
69STK40.68636650
70SIK30.65166041
71TAOK30.63292716
72PTK2B0.62203853
73PKN20.62073871
74PDGFRB0.60033920
75MAPK70.59998856
76CDK40.59654174
77MAP3K60.59549453
78TNK20.59542768
79TRPM70.57855224
80RAF10.57155447
81TESK20.56092711
82CDK90.54931126
83EPHA30.53434712
84NUAK10.52687578
85PDK10.51961004
86GRK70.51513481
87FLT30.50880699
88STK110.47590961
89ERN10.46781500
90MAP3K50.44855796
91PDPK10.44570843
92RET0.44518043
93IRAK10.44225954
94HIPK20.44198246
95ALK0.43111708
96DYRK1B0.40699457
97FYN0.38541483
98NEK60.37734801
99CDK60.37510243
100INSR0.37279432
101ABL10.37027615
102KSR10.36607142
103FRK0.36204330
104EGFR0.34701897
105IGF1R0.34674636
106PASK0.34013099
107KDR0.33477759
108STK380.33094981
109TGFBR10.32876785
110YES10.32838746
111GRK50.32651436
112CDC42BPA0.32592626
113CAMK40.32191550
114MAP2K60.31254450
115PTK60.29863684
116RPS6KA60.28581697
117MAPK120.28468077
118MAPK40.28393133
119TAOK10.28169915
120MAP3K80.27951690
121TRIB30.25431267
122PRKCD0.25141533
123ATR0.24743051
124MAPK30.24723189
125RPS6KA50.23972464
126MAPK110.23752641
127ACVR1B0.23293394
128SGK30.22769747
129MAPKAPK20.22644465
130TYRO30.22486227
131MARK20.21698888
132FGR0.19395291

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053404.39395847
2Graft-versus-host disease_Homo sapiens_hsa053323.22414861
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.06043539
4* T cell receptor signaling pathway_Homo sapiens_hsa046602.98199178
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.95086222
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.78114016
7Allograft rejection_Homo sapiens_hsa053302.68409139
8Measles_Homo sapiens_hsa051622.64536502
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.62838222
10Leishmaniasis_Homo sapiens_hsa051402.50331906
11B cell receptor signaling pathway_Homo sapiens_hsa046622.44900421
12Antigen processing and presentation_Homo sapiens_hsa046122.43599643
13Osteoclast differentiation_Homo sapiens_hsa043802.24713702
14Hematopoietic cell lineage_Homo sapiens_hsa046402.15829533
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75861195
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75517445
17Autoimmune thyroid disease_Homo sapiens_hsa053201.74859998
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72608583
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.72605461
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70538743
21Herpes simplex infection_Homo sapiens_hsa051681.70106233
22Viral myocarditis_Homo sapiens_hsa054161.64389967
23Chemokine signaling pathway_Homo sapiens_hsa040621.57326618
24Type I diabetes mellitus_Homo sapiens_hsa049401.49576626
25Toxoplasmosis_Homo sapiens_hsa051451.46989945
26Influenza A_Homo sapiens_hsa051641.43034714
27Staphylococcus aureus infection_Homo sapiens_hsa051501.42646443
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39907679
29TNF signaling pathway_Homo sapiens_hsa046681.39599362
30* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38790758
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36708080
32Malaria_Homo sapiens_hsa051441.35766897
33Hepatitis B_Homo sapiens_hsa051611.34966764
34Acute myeloid leukemia_Homo sapiens_hsa052211.32615189
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.30007196
36Tuberculosis_Homo sapiens_hsa051521.28685732
37Legionellosis_Homo sapiens_hsa051341.25243179
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24922189
39Apoptosis_Homo sapiens_hsa042101.20800951
40Shigellosis_Homo sapiens_hsa051311.16378032
41Asthma_Homo sapiens_hsa053101.10806969
42Pertussis_Homo sapiens_hsa051331.08994631
43Pancreatic cancer_Homo sapiens_hsa052121.03978587
44Chronic myeloid leukemia_Homo sapiens_hsa052201.03826042
45HTLV-I infection_Homo sapiens_hsa051660.93656644
46Epstein-Barr virus infection_Homo sapiens_hsa051690.91292229
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90751321
48Hepatitis C_Homo sapiens_hsa051600.90627628
49Platelet activation_Homo sapiens_hsa046110.90138068
50Salmonella infection_Homo sapiens_hsa051320.88856189
51Dorso-ventral axis formation_Homo sapiens_hsa043200.88587728
52Rheumatoid arthritis_Homo sapiens_hsa053230.86418062
53Non-homologous end-joining_Homo sapiens_hsa034500.82943602
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79798981
55Prolactin signaling pathway_Homo sapiens_hsa049170.79451828
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74300230
57Viral carcinogenesis_Homo sapiens_hsa052030.74033795
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70524026
59Colorectal cancer_Homo sapiens_hsa052100.70495500
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.70068017
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68541111
62* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65434845
63VEGF signaling pathway_Homo sapiens_hsa043700.64026414
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63768657
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60881929
66Small cell lung cancer_Homo sapiens_hsa052220.59100857
67Non-small cell lung cancer_Homo sapiens_hsa052230.59030129
68African trypanosomiasis_Homo sapiens_hsa051430.58140937
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58013183
70Other glycan degradation_Homo sapiens_hsa005110.56534370
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.54769035
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54710931
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53570885
74GnRH signaling pathway_Homo sapiens_hsa049120.51090944
75FoxO signaling pathway_Homo sapiens_hsa040680.49487550
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49484940
77p53 signaling pathway_Homo sapiens_hsa041150.48029944
78ErbB signaling pathway_Homo sapiens_hsa040120.47754324
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47403100
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46497139
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45690279
82Regulation of autophagy_Homo sapiens_hsa041400.44350144
83Glioma_Homo sapiens_hsa052140.43555400
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.43218599
85Notch signaling pathway_Homo sapiens_hsa043300.42709527
86Long-term potentiation_Homo sapiens_hsa047200.40503097
87Type II diabetes mellitus_Homo sapiens_hsa049300.38809389
88Lysosome_Homo sapiens_hsa041420.38330749
89Inositol phosphate metabolism_Homo sapiens_hsa005620.38024187
90mTOR signaling pathway_Homo sapiens_hsa041500.37066160
91MAPK signaling pathway_Homo sapiens_hsa040100.36751364
92Insulin resistance_Homo sapiens_hsa049310.36635980
93Prostate cancer_Homo sapiens_hsa052150.36617188
94Endocytosis_Homo sapiens_hsa041440.35754536
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34292627
96Base excision repair_Homo sapiens_hsa034100.33891951
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.31369554
98Ras signaling pathway_Homo sapiens_hsa040140.30129665
99HIF-1 signaling pathway_Homo sapiens_hsa040660.29473393
100RNA degradation_Homo sapiens_hsa030180.29010431
101MicroRNAs in cancer_Homo sapiens_hsa052060.28867789
102Renal cell carcinoma_Homo sapiens_hsa052110.28617155
103Endometrial cancer_Homo sapiens_hsa052130.25624666
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25105717
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24987053
106Phagosome_Homo sapiens_hsa041450.24700738
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23456508
108Caffeine metabolism_Homo sapiens_hsa002320.23073296
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22980230
110Spliceosome_Homo sapiens_hsa030400.21966376
111Amoebiasis_Homo sapiens_hsa051460.21132903
112Choline metabolism in cancer_Homo sapiens_hsa052310.20961429
113Rap1 signaling pathway_Homo sapiens_hsa040150.20089990
114Pathways in cancer_Homo sapiens_hsa052000.19822137
115Mismatch repair_Homo sapiens_hsa034300.19121099
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19041817

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