PTPRD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.60109677
2central nervous system myelination (GO:0022010)8.60109677
3fatty acid elongation (GO:0030497)6.10415544
4myelination (GO:0042552)5.54668144
5axon ensheathment (GO:0008366)5.53052656
6ensheathment of neurons (GO:0007272)5.53052656
7long-chain fatty acid biosynthetic process (GO:0042759)4.88974881
8negative regulation of neurotransmitter secretion (GO:0046929)4.82086732
9pyrimidine nucleobase catabolic process (GO:0006208)4.64209047
10* presynaptic membrane organization (GO:0097090)4.45218907
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.42977137
12negative regulation of neurotransmitter transport (GO:0051589)4.40647702
13neuron cell-cell adhesion (GO:0007158)4.21814066
14auditory behavior (GO:0031223)4.04653009
15central nervous system projection neuron axonogenesis (GO:0021952)4.01629931
16glycerophospholipid catabolic process (GO:0046475)3.91465317
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.90147650
18oligodendrocyte differentiation (GO:0048709)3.87449753
19apical protein localization (GO:0045176)3.85322840
20establishment of mitochondrion localization (GO:0051654)3.81010863
21L-amino acid import (GO:0043092)3.77190652
22nucleobase catabolic process (GO:0046113)3.75835866
23cell migration in hindbrain (GO:0021535)3.72880941
24* presynaptic membrane assembly (GO:0097105)3.69825073
25cerebellar granule cell differentiation (GO:0021707)3.67064523
26asymmetric protein localization (GO:0008105)3.57799640
27myelin maintenance (GO:0043217)3.57673120
28positive regulation of dendritic spine morphogenesis (GO:0061003)3.57625320
29cholesterol biosynthetic process (GO:0006695)3.54589911
30positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.53827217
31regulation of synapse structural plasticity (GO:0051823)3.52092221
32response to auditory stimulus (GO:0010996)3.49507909
33negative regulation of protein localization to cell surface (GO:2000009)3.48913311
34neuronal action potential propagation (GO:0019227)3.48704249
35exploration behavior (GO:0035640)3.48269030
36mechanosensory behavior (GO:0007638)3.43882387
37transmission of nerve impulse (GO:0019226)3.42653004
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40444705
39sodium ion export (GO:0071436)3.38614404
40photoreceptor cell differentiation (GO:0046530)3.37985569
41eye photoreceptor cell differentiation (GO:0001754)3.37985569
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35368961
43startle response (GO:0001964)3.34165965
44layer formation in cerebral cortex (GO:0021819)3.32820619
45locomotory exploration behavior (GO:0035641)3.31778091
46cerebral cortex radially oriented cell migration (GO:0021799)3.31003136
47adult walking behavior (GO:0007628)3.28121097
48regulation of collateral sprouting (GO:0048670)3.26598422
49astrocyte development (GO:0014002)3.25553954
50response to methylmercury (GO:0051597)3.24490355
51cellular potassium ion homeostasis (GO:0030007)3.23255390
52regulation of glutamate receptor signaling pathway (GO:1900449)3.19385451
53cell communication by electrical coupling (GO:0010644)3.18790256
54response to redox state (GO:0051775)3.14063173
55negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.13053879
56long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.12813267
57neuron recognition (GO:0008038)3.12710088
58positive regulation of action potential (GO:0045760)3.11783606
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10583259
60peptidyl-tyrosine autophosphorylation (GO:0038083)3.09683854
61central nervous system neuron axonogenesis (GO:0021955)3.09499789
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08929243
63neurotransmitter secretion (GO:0007269)3.08491711
64sterol biosynthetic process (GO:0016126)3.05771582
65positive regulation of dendritic spine development (GO:0060999)3.03561193
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03045756
67positive regulation of synapse maturation (GO:0090129)3.02613848
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02475043
69substantia nigra development (GO:0021762)3.02458599
70ionotropic glutamate receptor signaling pathway (GO:0035235)3.01151390
71gamma-aminobutyric acid transport (GO:0015812)3.00668370
72creatine metabolic process (GO:0006600)3.00159585
73establishment of nucleus localization (GO:0040023)2.99475890
74regulation of synaptic vesicle transport (GO:1902803)2.99228109
75regulation of neuronal synaptic plasticity (GO:0048168)2.98954276
76negative regulation of axonogenesis (GO:0050771)2.98592898
77gamma-aminobutyric acid signaling pathway (GO:0007214)2.97772056
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.96947546
79synapse assembly (GO:0007416)2.94722233
80import into cell (GO:0098657)2.93342727
81membrane depolarization during action potential (GO:0086010)2.92362821
82negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92069740
83neuronal ion channel clustering (GO:0045161)2.91859511
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91840834
85long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.91523740
86peripheral nervous system axon ensheathment (GO:0032292)2.90746661
87myelination in peripheral nervous system (GO:0022011)2.90746661
88positive regulation of oligodendrocyte differentiation (GO:0048714)2.84298963
89regulation of synapse assembly (GO:0051963)2.83833092
90neuron remodeling (GO:0016322)2.83070819
91regulation of postsynaptic membrane potential (GO:0060078)2.80161431
92regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78792564
93protein localization to synapse (GO:0035418)2.78346387
94axonal fasciculation (GO:0007413)2.78059064
95fatty-acyl-CoA biosynthetic process (GO:0046949)2.77969544
96glutamate receptor signaling pathway (GO:0007215)2.77432712
97synaptic transmission, glutamatergic (GO:0035249)2.76875500
98nerve growth factor signaling pathway (GO:0038180)2.76089400
99dendritic spine morphogenesis (GO:0060997)2.75758729
100negative regulation of dendrite development (GO:2000171)2.75195275
101long-term memory (GO:0007616)2.74971658
102amino acid import (GO:0043090)2.74031533
103regulation of axon guidance (GO:1902667)2.73270628
104adhesion of symbiont to host cell (GO:0044650)2.72676216
105virion attachment to host cell (GO:0019062)2.72676216
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72524549
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72134191
108mitochondrion transport along microtubule (GO:0047497)2.72134191
109cochlea development (GO:0090102)2.72048903
110limb bud formation (GO:0060174)2.71989708
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71322580
112regulation of synaptic transmission, GABAergic (GO:0032228)2.71196667
113synapse organization (GO:0050808)2.70926462
114glutamate secretion (GO:0014047)2.70849091
115isoprenoid biosynthetic process (GO:0008299)2.70842488
116cellular sodium ion homeostasis (GO:0006883)2.70709689
117neuron-neuron synaptic transmission (GO:0007270)2.70250396
118cell communication involved in cardiac conduction (GO:0086065)2.69939127
119retinal ganglion cell axon guidance (GO:0031290)2.69292902
120cellular response to epinephrine stimulus (GO:0071872)2.69076237
121membrane tubulation (GO:0097320)2.68880926
122protein palmitoylation (GO:0018345)2.67336220
123vocalization behavior (GO:0071625)2.66978686
124synaptic vesicle exocytosis (GO:0016079)2.66605389
125dendrite morphogenesis (GO:0048813)2.66146383
126neuromuscular process controlling balance (GO:0050885)2.65193015
127regulation of axon extension involved in axon guidance (GO:0048841)2.65131779
128regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64790520
129membrane depolarization (GO:0051899)2.64284798
130regulation of neurotransmitter secretion (GO:0046928)2.62290564
131spinal cord development (GO:0021510)2.62204735
132axonogenesis (GO:0007409)2.61803407
133negative regulation of axon extension (GO:0030517)2.61742778
134magnesium ion transport (GO:0015693)2.61480169
135L-phenylalanine catabolic process (GO:0006559)2.60929293
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60929293
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60789712
138postsynaptic membrane organization (GO:0001941)2.60575403
139fatty-acyl-CoA metabolic process (GO:0035337)2.60451793
140very long-chain fatty acid metabolic process (GO:0000038)2.60120955
141regulation of synaptic vesicle exocytosis (GO:2000300)2.58758831
142synaptic vesicle maturation (GO:0016188)2.56782763
143positive regulation of synapse assembly (GO:0051965)2.55323180
144axon development (GO:0061564)2.52876504
145negative regulation of JUN kinase activity (GO:0043508)2.52195333
146positive regulation of membrane potential (GO:0045838)2.51325749
147amyloid precursor protein metabolic process (GO:0042982)2.48451479
148membrane hyperpolarization (GO:0060081)2.48256895
149negative regulation of synaptic transmission (GO:0050805)2.47436348
150positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46970113
151regulation of dendritic spine development (GO:0060998)2.46060111
152response to epinephrine (GO:0071871)2.42541304
153regulation of dendritic spine morphogenesis (GO:0061001)2.42464465
154neurotransmitter-gated ion channel clustering (GO:0072578)2.41862972
155cyclic nucleotide catabolic process (GO:0009214)2.41791084
156dendrite development (GO:0016358)2.41467390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* GBX2_23144817_ChIP-Seq_PC3_Human3.79497120
2EZH2_22144423_ChIP-Seq_EOC_Human3.41071715
3TAF15_26573619_Chip-Seq_HEK293_Human2.62482825
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60290539
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59894620
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47094878
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32935501
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23966133
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23966133
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.22873673
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18682649
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.16071025
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15313348
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13919284
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11679955
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10875998
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09441820
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00761590
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98818112
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95162862
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94539771
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.93740728
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90090373
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84459527
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80727382
26DROSHA_22980978_ChIP-Seq_HELA_Human1.79928173
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79383790
28AR_21572438_ChIP-Seq_LNCaP_Human1.75662553
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73406085
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70982561
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69292235
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68054521
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67257345
34IGF1R_20145208_ChIP-Seq_DFB_Human1.63483046
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62306365
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60827967
37ER_23166858_ChIP-Seq_MCF-7_Human1.60400288
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.59659522
39* SMAD3_21741376_ChIP-Seq_EPCs_Human1.59536886
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59338766
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.58945367
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56710259
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56262429
44VDR_22108803_ChIP-Seq_LS180_Human1.56089806
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55282390
46P300_19829295_ChIP-Seq_ESCs_Human1.54609561
47* REST_21632747_ChIP-Seq_MESCs_Mouse1.54426824
48FUS_26573619_Chip-Seq_HEK293_Human1.47512641
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46298996
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44689552
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.43016454
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.41520206
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41022322
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40713120
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.39148458
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37091912
57* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31387288
58* STAT3_23295773_ChIP-Seq_U87_Human1.29389557
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.25524050
60* SOX9_26525672_Chip-Seq_HEART_Mouse1.22678673
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22104954
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21805119
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21338338
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21305935
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21225745
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20791645
67* REST_18959480_ChIP-ChIP_MESCs_Mouse1.19746720
68EWS_26573619_Chip-Seq_HEK293_Human1.18896839
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.17755338
70* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17159989
71TCF4_23295773_ChIP-Seq_U87_Human1.16432483
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16336165
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15449779
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.15384274
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14471092
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13816849
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13073784
78* AR_19668381_ChIP-Seq_PC3_Human1.12266142
79* RNF2_27304074_Chip-Seq_NSC_Mouse1.11289510
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.10925943
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10405888
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08753929
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07689753
84AHR_22903824_ChIP-Seq_MCF-7_Human1.07082479
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06968614
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06534027
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06534027
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06273770
89* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06090062
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05178353
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.05148149
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04717421
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04235602
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02250710
95TP53_16413492_ChIP-PET_HCT116_Human1.01896553
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01432587
97* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00688233
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00450148
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00286364
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.99889970
101* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99456542
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.99329070
103* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99157324
104AR_25329375_ChIP-Seq_VCAP_Human0.98390240
105EP300_21415370_ChIP-Seq_HL-1_Mouse0.98254027
106P300_18555785_Chip-Seq_ESCs_Mouse0.97872465
107E2F1_18555785_Chip-Seq_ESCs_Mouse0.97690043
108TP53_18474530_ChIP-ChIP_U2OS_Human0.97215586
109* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96983780
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96913559
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96913559
112* RUNX2_22187159_ChIP-Seq_PCA_Human0.96549819
113RING1B_27294783_Chip-Seq_ESCs_Mouse0.96346655
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.95650729
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95515821
116P53_22387025_ChIP-Seq_ESCs_Mouse0.95156396
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94936859
118HTT_18923047_ChIP-ChIP_STHdh_Human0.94803137
119* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94466867
120* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92131254
121KDM2B_26808549_Chip-Seq_REH_Human0.92089840
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91403698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.73131725
2MP0000920_abnormal_myelination4.01570337
3MP0004270_analgesia3.73109048
4MP0004859_abnormal_synaptic_plasticity3.44744480
5MP0001486_abnormal_startle_reflex2.74093325
6MP0002064_seizures2.69232542
7MP0002272_abnormal_nervous_system2.69225174
8* MP0003635_abnormal_synaptic_transmissio2.55350169
9MP0003690_abnormal_glial_cell2.53271935
10MP0009046_muscle_twitch2.52147786
11MP0009745_abnormal_behavioral_response2.48142672
12MP0005423_abnormal_somatic_nervous2.41296783
13MP0005171_absent_coat_pigmentation2.33424560
14MP0004885_abnormal_endolymph2.30561735
15MP0000778_abnormal_nervous_system2.29703114
16MP0003950_abnormal_plasma_membrane2.27475000
17MP0004742_abnormal_vestibular_system2.24597807
18MP0003329_amyloid_beta_deposits2.24197241
19MP0001529_abnormal_vocalization2.19834554
20MP0002734_abnormal_mechanical_nocicepti2.11395979
21MP0001905_abnormal_dopamine_level2.00588244
22MP0004142_abnormal_muscle_tone1.98771966
23MP0002572_abnormal_emotion/affect_behav1.94120642
24MP0003122_maternal_imprinting1.92446094
25* MP0002063_abnormal_learning/memory/cond1.91315852
26MP0005409_darkened_coat_color1.90810238
27MP0001485_abnormal_pinna_reflex1.84771592
28MP0003634_abnormal_glial_cell1.80219509
29MP0003136_yellow_coat_color1.77698419
30MP0001440_abnormal_grooming_behavior1.76333770
31MP0003787_abnormal_imprinting1.76103397
32MP0002229_neurodegeneration1.70892329
33MP0005551_abnormal_eye_electrophysiolog1.67865847
34MP0002067_abnormal_sensory_capabilities1.65063162
35MP0001968_abnormal_touch/_nociception1.54801486
36MP0005386_behavior/neurological_phenoty1.51520232
37MP0004924_abnormal_behavior1.51520232
38MP0003632_abnormal_nervous_system1.48181877
39MP0008569_lethality_at_weaning1.45658995
40MP0000569_abnormal_digit_pigmentation1.43289720
41* MP0002882_abnormal_neuron_morphology1.42527941
42* MP0000955_abnormal_spinal_cord1.39438684
43MP0003121_genomic_imprinting1.36373766
44MP0003631_nervous_system_phenotype1.33004472
45* MP0002066_abnormal_motor_capabilities/c1.32968953
46MP0001970_abnormal_pain_threshold1.32707538
47MP0000462_abnormal_digestive_system1.32578909
48MP0001501_abnormal_sleep_pattern1.31271548
49MP0004043_abnormal_pH_regulation1.30341627
50MP0003633_abnormal_nervous_system1.29105709
51MP0002735_abnormal_chemical_nociception1.28318076
52MP0002733_abnormal_thermal_nociception1.28026189
53MP0004147_increased_porphyrin_level1.27893832
54MP0005187_abnormal_penis_morphology1.21937383
55MP0003861_abnormal_nervous_system1.19788909
56MP0001963_abnormal_hearing_physiology1.18833056
57MP0010678_abnormal_skin_adnexa1.18729225
58MP0005410_abnormal_fertilization1.17894822
59MP0003195_calcinosis1.16668628
60MP0000537_abnormal_urethra_morphology1.16534356
61MP0002184_abnormal_innervation1.15426066
62MP0002736_abnormal_nociception_after1.15318970
63MP0005451_abnormal_body_composition1.14286018
64MP0003890_abnormal_embryonic-extraembry1.10772852
65MP0002638_abnormal_pupillary_reflex1.10034259
66MP0002557_abnormal_social/conspecific_i1.09863793
67MP0009780_abnormal_chondrocyte_physiolo1.09404887
68MP0000534_abnormal_ureter_morphology1.08410996
69* MP0002752_abnormal_somatic_nervous1.08213601
70MP0005248_abnormal_Harderian_gland1.07903472
71MP0000604_amyloidosis1.07374258
72MP0003119_abnormal_digestive_system1.05958154
73MP0001188_hyperpigmentation1.04715289
74MP0000383_abnormal_hair_follicle1.04582091
75MP0004145_abnormal_muscle_electrophysio1.03174511
76MP0001502_abnormal_circadian_rhythm1.02371845
77MP0004381_abnormal_hair_follicle1.01310042
78MP0001661_extended_life_span1.00450896
79MP0002233_abnormal_nose_morphology0.99502433
80MP0003938_abnormal_ear_development0.99348129
81MP0001299_abnormal_eye_distance/0.98856211
82MP0002152_abnormal_brain_morphology0.98363573
83MP0004134_abnormal_chest_morphology0.97971219
84MP0002822_catalepsy0.97764421
85MP0002751_abnormal_autonomic_nervous0.97712667
86MP0001177_atelectasis0.95737817
87MP0005646_abnormal_pituitary_gland0.95623412
88MP0000566_synostosis0.94963150
89MP0001293_anophthalmia0.93696339
90MP0006292_abnormal_olfactory_placode0.93010075
91MP0002653_abnormal_ependyma_morphology0.92851131
92MP0001346_abnormal_lacrimal_gland0.91882820
93MP0002102_abnormal_ear_morphology0.91457320
94MP0002249_abnormal_larynx_morphology0.90317556
95MP0004811_abnormal_neuron_physiology0.89731588
96MP0005195_abnormal_posterior_eye0.89566121
97MP0004133_heterotaxia0.89450732
98MP0006276_abnormal_autonomic_nervous0.88961328
99MP0000747_muscle_weakness0.86031985
100MP0000026_abnormal_inner_ear0.85414962
101MP0002909_abnormal_adrenal_gland0.84744886
102MP0003879_abnormal_hair_cell0.83828911
103MP0003385_abnormal_body_wall0.83572500
104MP0000049_abnormal_middle_ear0.83211089
105MP0003283_abnormal_digestive_organ0.81084488
106MP0005499_abnormal_olfactory_system0.80046843
107MP0005394_taste/olfaction_phenotype0.80046843
108MP0002234_abnormal_pharynx_morphology0.79471453
109MP0005645_abnormal_hypothalamus_physiol0.77373687
110MP0000631_abnormal_neuroendocrine_gland0.76705832
111MP0001984_abnormal_olfaction0.76231563
112MP0002697_abnormal_eye_size0.75859965
113* MP0002081_perinatal_lethality0.74990807
114MP0002938_white_spotting0.74428843
115MP0005253_abnormal_eye_physiology0.74012726
116MP0003123_paternal_imprinting0.73371075
117MP0000647_abnormal_sebaceous_gland0.73138061
118MP0003937_abnormal_limbs/digits/tail_de0.72526204
119MP0008875_abnormal_xenobiotic_pharmacok0.72498281
120MP0002090_abnormal_vision0.69262602
121MP0006072_abnormal_retinal_apoptosis0.68771823
122MP0003806_abnormal_nucleotide_metabolis0.68739889
123MP0000579_abnormal_nail_morphology0.66987251
124MP0003137_abnormal_impulse_conducting0.66043604
125MP0008260_abnormal_autophagy0.63578697
126MP0000762_abnormal_tongue_morphology0.63352372
127MP0003868_abnormal_feces_composition0.62162196
128MP0008874_decreased_physiological_sensi0.61107764
129MP0000639_abnormal_adrenal_gland0.60243347
130MP0001340_abnormal_eyelid_morphology0.58746512
131MP0004085_abnormal_heartbeat0.58486773
132* MP0002069_abnormal_eating/drinking_beha0.58344055

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.04012087
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.04012087
3Neurofibrillary tangles (HP:0002185)5.45327680
4Abnormality of the corticospinal tract (HP:0002492)4.91589318
5Sensory axonal neuropathy (HP:0003390)4.84735746
6Parakeratosis (HP:0001036)4.26212264
7Focal motor seizures (HP:0011153)4.06872858
8Cerebral inclusion bodies (HP:0100314)4.02968029
9Febrile seizures (HP:0002373)3.95191904
10Spastic gait (HP:0002064)3.75901002
11Myokymia (HP:0002411)3.57181377
12Peripheral hypomyelination (HP:0007182)3.45485929
13Supranuclear gaze palsy (HP:0000605)3.45142991
14Scanning speech (HP:0002168)3.42808964
15Intention tremor (HP:0002080)3.39669392
16Dysmetria (HP:0001310)3.36674406
17Hyperventilation (HP:0002883)3.36332581
18Termporal pattern (HP:0011008)3.26220351
19Insidious onset (HP:0003587)3.26220351
20Epileptic encephalopathy (HP:0200134)3.15272709
21Onion bulb formation (HP:0003383)3.12609685
22Retinal dysplasia (HP:0007973)3.06311513
23Akinesia (HP:0002304)3.05859686
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.96861017
25Cutaneous finger syndactyly (HP:0010554)2.95536842
26Ankle clonus (HP:0011448)2.93088302
27Alacrima (HP:0000522)2.91945266
28Atonic seizures (HP:0010819)2.84177266
29Thickened helices (HP:0000391)2.83914885
30Focal seizures (HP:0007359)2.71115036
31Broad-based gait (HP:0002136)2.63366701
32Cutaneous syndactyly (HP:0012725)2.62037373
33Vitreoretinal degeneration (HP:0000655)2.60346043
34Hemiparesis (HP:0001269)2.58534598
35Hepatoblastoma (HP:0002884)2.57810813
36Limb dystonia (HP:0002451)2.52011765
37Anteriorly placed anus (HP:0001545)2.51780659
38Cerebral hypomyelination (HP:0006808)2.50174132
39Slow saccadic eye movements (HP:0000514)2.48649955
40Abnormal auditory evoked potentials (HP:0006958)2.48648588
41Gaze-evoked nystagmus (HP:0000640)2.41789031
42Partial agenesis of the corpus callosum (HP:0001338)2.35783014
43Clumsiness (HP:0002312)2.34272398
44Lower limb muscle weakness (HP:0007340)2.33273694
45Decreased lacrimation (HP:0000633)2.30990968
46Midline defect of the nose (HP:0004122)2.30566247
47Absent speech (HP:0001344)2.28741243
48Spastic tetraparesis (HP:0001285)2.28142425
49Polyphagia (HP:0002591)2.27805021
50Action tremor (HP:0002345)2.24784767
51Pheochromocytoma (HP:0002666)2.24502869
52Aplasia involving bones of the extremities (HP:0009825)2.23970741
53Aplasia involving bones of the upper limbs (HP:0009823)2.23970741
54Aplasia of the phalanges of the hand (HP:0009802)2.23970741
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23916048
56Short 4th metacarpal (HP:0010044)2.23916048
57Abnormality of the labia minora (HP:0012880)2.22546759
58Increased serum pyruvate (HP:0003542)2.21392586
59Abnormality of glycolysis (HP:0004366)2.21392586
60Coronal craniosynostosis (HP:0004440)2.20683420
61Abnormal eating behavior (HP:0100738)2.20377616
62Impaired vibration sensation in the lower limbs (HP:0002166)2.19739153
63Dialeptic seizures (HP:0011146)2.16872809
64Absent septum pellucidum (HP:0001331)2.15442553
65Leukodystrophy (HP:0002415)2.15245823
66Spastic paraparesis (HP:0002313)2.13632701
67Epileptiform EEG discharges (HP:0011182)2.13061933
68Abnormality of the lower motor neuron (HP:0002366)2.12790739
69Metabolic alkalosis (HP:0200114)2.12045771
70Cerebral hemorrhage (HP:0001342)2.11477605
71Increased circulating renin level (HP:0000848)2.11422909
72Generalized myoclonic seizures (HP:0002123)2.10509475
73Abnormality of the ischium (HP:0003174)2.10500186
74Protruding tongue (HP:0010808)2.09873603
75Renal hypoplasia (HP:0000089)2.06105589
76Dysdiadochokinesis (HP:0002075)2.04905426
77Aqueductal stenosis (HP:0002410)2.04649850
78Type II lissencephaly (HP:0007260)2.04020178
79Autoamputation (HP:0001218)2.03445495
80Infantile muscular hypotonia (HP:0008947)2.03285251
81Synostosis involving the elbow (HP:0003938)2.03264733
82Humeroradial synostosis (HP:0003041)2.03264733
83Megalencephaly (HP:0001355)2.02973151
84Urinary bladder sphincter dysfunction (HP:0002839)2.01694972
85Blue irides (HP:0000635)2.01459254
86Hypophosphatemic rickets (HP:0004912)2.00952474
87Congenital ichthyosiform erythroderma (HP:0007431)1.99137253
88Drooling (HP:0002307)1.98716108
89Excessive salivation (HP:0003781)1.98716108
90Gait imbalance (HP:0002141)1.97026973
91Progressive cerebellar ataxia (HP:0002073)1.96772846
92Septo-optic dysplasia (HP:0100842)1.96588205
93Clonus (HP:0002169)1.96150752
94Methylmalonic acidemia (HP:0002912)1.95971368
95Morphological abnormality of the pyramidal tract (HP:0002062)1.95105633
96Hemiplegia (HP:0002301)1.94464353
97Genetic anticipation (HP:0003743)1.94366995
98Split foot (HP:0001839)1.92102394
99Genital tract atresia (HP:0001827)1.91999053
100Absence seizures (HP:0002121)1.91970931
101EEG with generalized epileptiform discharges (HP:0011198)1.91826609
102Amyotrophic lateral sclerosis (HP:0007354)1.91511164
103Preaxial foot polydactyly (HP:0001841)1.91472357
104Neuroendocrine neoplasm (HP:0100634)1.90970589
105Bronchomalacia (HP:0002780)1.90959253
106Hypoplastic pelvis (HP:0008839)1.89403117
107Poor eye contact (HP:0000817)1.89380214
108Abnormal social behavior (HP:0012433)1.89343173
109Impaired social interactions (HP:0000735)1.89343173
110Hypsarrhythmia (HP:0002521)1.89073256
111Tracheomalacia (HP:0002779)1.86768904
112Cupped ear (HP:0000378)1.85891550
113Urinary urgency (HP:0000012)1.84641575
114Optic nerve hypoplasia (HP:0000609)1.83588856
115Widely spaced teeth (HP:0000687)1.81151251
116Poor speech (HP:0002465)1.80594013
117Buphthalmos (HP:0000557)1.79747468
118Abnormality of the 4th metacarpal (HP:0010012)1.79164506
119Amblyopia (HP:0000646)1.79121638
120Truncal ataxia (HP:0002078)1.78620958
121Abnormality of the septum pellucidum (HP:0007375)1.78089031
122Hypomagnesemia (HP:0002917)1.76843675
123Abnormality of salivation (HP:0100755)1.76174681
124Intrahepatic cholestasis (HP:0001406)1.76032095
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75834709
126Papillary thyroid carcinoma (HP:0002895)1.75121959
127Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75053454
128Intellectual disability, moderate (HP:0002342)1.74746798
129Generalized tonic-clonic seizures (HP:0002069)1.74423744
130Bowel incontinence (HP:0002607)1.73929618
131Premature skin wrinkling (HP:0100678)1.73851707
132Vaginal atresia (HP:0000148)1.73042801
133Turricephaly (HP:0000262)1.73037301
134Intestinal atresia (HP:0011100)1.71336932
135Stridor (HP:0010307)1.71106218
136Status epilepticus (HP:0002133)1.71059233
137Progressive inability to walk (HP:0002505)1.70427523
138Absent/shortened dynein arms (HP:0200106)1.69207005
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.69207005
140Morphological abnormality of the middle ear (HP:0008609)1.68366230
141Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68328127
142Sleep apnea (HP:0010535)1.68287698
143Diminished movement (HP:0002374)1.68251597
144Hypoplasia of the corpus callosum (HP:0002079)1.67890329
145CNS hypomyelination (HP:0003429)1.67845189
146Neuronal loss in central nervous system (HP:0002529)1.67743345
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.66892560
148Torticollis (HP:0000473)1.64111726
149Abnormality of binocular vision (HP:0011514)1.62720505
150Diplopia (HP:0000651)1.62720505
151Oligodactyly (hands) (HP:0001180)1.61335736
152Specific learning disability (HP:0001328)1.60807894
153Lissencephaly (HP:0001339)1.60778419
154Exotropia (HP:0000577)1.57077462
155Anophthalmia (HP:0000528)1.56912732
156Partial duplication of thumb phalanx (HP:0009944)1.56886150
157Postural instability (HP:0002172)1.56081293
158Gastrointestinal atresia (HP:0002589)1.55717025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.28843208
2OXSR14.40163477
3CASK3.07539827
4CDK192.94942929
5TNIK2.74798807
6EPHA42.53656583
7BCR2.36946944
8PNCK2.17918825
9WNK42.14691576
10EPHB12.14192037
11MARK12.13650378
12PKN12.12032091
13FGFR22.09822327
14PRPF4B1.95251140
15WNK11.86396185
16MET1.77562262
17PAK61.75580924
18CSNK1G31.75505033
19CSNK1A1L1.74900623
20NEK61.65773529
21ICK1.61250861
22UHMK11.56385692
23CSNK1G21.54113013
24CSNK1G11.43204228
25PBK1.43085598
26NTRK11.42210358
27CAMK2B1.41552058
28LATS21.39814715
29MAPKAPK51.39538000
30SGK21.38975982
31SIK21.36816201
32NTRK31.33238407
33EPHB21.30426579
34SGK2231.28568171
35SGK4941.28568171
36FGR1.27495927
37ROCK21.17398716
38LIMK11.10576267
39CAMK2D1.09434736
40CDK51.09022171
41MAP3K41.08933133
42PRKD31.03444901
43CAMK1G1.01187128
44CAMKK10.99801163
45PINK10.99397531
46NTRK20.98753458
47PAK30.98718919
48CAMK2A0.98053943
49MKNK20.97260072
50CAMK2G0.96013770
51EPHA30.94424549
52FRK0.93007449
53MAP2K70.92118379
54DAPK20.91449428
55MARK20.89625338
56CLK10.87803579
57MAP3K90.86969958
58TYRO30.85863557
59CDK140.84191236
60MAPK130.83913906
61ERBB40.81648929
62PHKG20.80479323
63PHKG10.80479323
64PKN20.79396884
65CDK150.77815724
66SGK30.77074644
67CCNB10.76426592
68OBSCN0.76405381
69CDK180.74630979
70LATS10.74428050
71BMPR1B0.73913551
72DYRK20.72893540
73PRKCQ0.71882664
74MINK10.70297289
75PRKCE0.69360786
76CDK11A0.68883572
77STK110.68753787
78CAMKK20.68245709
79CAMK40.66406053
80MUSK0.66278550
81CAMK1D0.66223004
82PDPK10.64183498
83FGFR10.62944597
84FES0.60437875
85KSR20.58004866
86STK38L0.57967933
87WNK30.57921417
88AKT30.57060194
89ARAF0.55555503
90PRKG10.55411296
91FYN0.55371179
92MAP4K20.54714888
93MKNK10.54313660
94PLK20.54214961
95MAP3K130.53716793
96MAPK70.53461578
97MAPK150.53347429
98PRKCG0.52922356
99IRAK20.52915659
100PRKCH0.52202873
101ERBB20.52181106
102DYRK1A0.51879956
103DMPK0.50882080
104RPS6KA30.49177918
105PRKD10.48057235
106ROCK10.47990327
107ERBB30.47930497
108CSNK1D0.47442640
109PDGFRA0.47393017
110YES10.46887332
111MAP2K40.44959175
112PIK3CA0.43772334
113CDK30.43149791
114PTK2B0.42625945
115CSNK1A10.42360370
116SGK10.42326413
117BRD40.42260586
118CSNK1E0.41753218
119RET0.40547825
120KSR10.40418164
121MST40.39927763
122TESK20.38995706
123PRKACB0.38205668
124GRK50.38008838
125INSRR0.37212291
126CAMK10.35619811
127PDK10.35526675
128MAP3K100.35505304
129GSK3B0.35039414
130ADRBK20.32798689
131PRKACA0.31629744
132DDR20.30828610
133MAPK100.29674429
134GRK70.29560045
135PRKCZ0.29476713

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.66219571
2Steroid biosynthesis_Homo sapiens_hsa001003.46430957
3Fatty acid elongation_Homo sapiens_hsa000623.22504622
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18482997
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32066581
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21721383
7Ether lipid metabolism_Homo sapiens_hsa005652.21201161
8Nicotine addiction_Homo sapiens_hsa050332.20711744
9GABAergic synapse_Homo sapiens_hsa047272.00153964
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99724508
11Sulfur metabolism_Homo sapiens_hsa009201.97413185
12Axon guidance_Homo sapiens_hsa043601.94975457
13Glutamatergic synapse_Homo sapiens_hsa047241.91069251
14Butanoate metabolism_Homo sapiens_hsa006501.84761633
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79941091
16Morphine addiction_Homo sapiens_hsa050321.67730123
17Circadian entrainment_Homo sapiens_hsa047131.52951678
18Serotonergic synapse_Homo sapiens_hsa047261.50548152
19Synaptic vesicle cycle_Homo sapiens_hsa047211.44396934
20Nitrogen metabolism_Homo sapiens_hsa009101.43316602
21Long-term depression_Homo sapiens_hsa047301.42949087
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42890492
23Histidine metabolism_Homo sapiens_hsa003401.30931785
24Salivary secretion_Homo sapiens_hsa049701.26866736
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26088308
26Hippo signaling pathway_Homo sapiens_hsa043901.23421713
27Basal cell carcinoma_Homo sapiens_hsa052171.23194348
28Oxidative phosphorylation_Homo sapiens_hsa001901.19230534
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17694114
30Sphingolipid metabolism_Homo sapiens_hsa006001.15644676
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15406430
32Dilated cardiomyopathy_Homo sapiens_hsa054141.14245844
33Vitamin B6 metabolism_Homo sapiens_hsa007501.13598805
34Estrogen signaling pathway_Homo sapiens_hsa049151.10458374
35Phototransduction_Homo sapiens_hsa047441.09518398
36Dopaminergic synapse_Homo sapiens_hsa047281.08586263
37Collecting duct acid secretion_Homo sapiens_hsa049661.07827018
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07628613
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06452794
40Amphetamine addiction_Homo sapiens_hsa050311.06434884
41Cocaine addiction_Homo sapiens_hsa050301.05688714
42Linoleic acid metabolism_Homo sapiens_hsa005911.00948159
43Taste transduction_Homo sapiens_hsa047420.97135408
44Long-term potentiation_Homo sapiens_hsa047200.97056447
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.95031103
46Cholinergic synapse_Homo sapiens_hsa047250.94436138
47Renin secretion_Homo sapiens_hsa049240.94400155
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92105822
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.92062222
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90441353
51Gastric acid secretion_Homo sapiens_hsa049710.88451513
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88450502
53Alzheimers disease_Homo sapiens_hsa050100.88279190
54Thyroid hormone synthesis_Homo sapiens_hsa049180.87696775
55Rap1 signaling pathway_Homo sapiens_hsa040150.87360131
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85859034
57Renal cell carcinoma_Homo sapiens_hsa052110.85558246
58Fatty acid metabolism_Homo sapiens_hsa012120.85552025
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85047857
60Type II diabetes mellitus_Homo sapiens_hsa049300.84386935
61Olfactory transduction_Homo sapiens_hsa047400.83864841
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.82102764
63Ovarian steroidogenesis_Homo sapiens_hsa049130.80763739
64Vibrio cholerae infection_Homo sapiens_hsa051100.79723865
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78963358
66ErbB signaling pathway_Homo sapiens_hsa040120.77635737
67Protein digestion and absorption_Homo sapiens_hsa049740.77365819
68Arginine and proline metabolism_Homo sapiens_hsa003300.76819270
69Glioma_Homo sapiens_hsa052140.76223588
70Propanoate metabolism_Homo sapiens_hsa006400.76064080
71Insulin secretion_Homo sapiens_hsa049110.75901129
72Cardiac muscle contraction_Homo sapiens_hsa042600.74513192
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74271876
74Oocyte meiosis_Homo sapiens_hsa041140.72816627
75cAMP signaling pathway_Homo sapiens_hsa040240.71145342
76Endometrial cancer_Homo sapiens_hsa052130.70949764
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70459218
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68643799
79Alcoholism_Homo sapiens_hsa050340.68025990
80Gap junction_Homo sapiens_hsa045400.67778238
81Calcium signaling pathway_Homo sapiens_hsa040200.67603398
82Peroxisome_Homo sapiens_hsa041460.67325761
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66842880
84Tight junction_Homo sapiens_hsa045300.66771691
85Oxytocin signaling pathway_Homo sapiens_hsa049210.66698295
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66694340
87Ras signaling pathway_Homo sapiens_hsa040140.65936267
88Protein export_Homo sapiens_hsa030600.64601338
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64080336
90Parkinsons disease_Homo sapiens_hsa050120.63921774
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63331566
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.62604265
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.62549089
94Circadian rhythm_Homo sapiens_hsa047100.62413580
95Fatty acid biosynthesis_Homo sapiens_hsa000610.61631678
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59930416
97Dorso-ventral axis formation_Homo sapiens_hsa043200.59189333
98Adherens junction_Homo sapiens_hsa045200.58895205
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58712127
100Colorectal cancer_Homo sapiens_hsa052100.57637329
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57420829
102Pancreatic secretion_Homo sapiens_hsa049720.56110543
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55744949
104Bile secretion_Homo sapiens_hsa049760.55664499
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.54561659
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53703115
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53048478
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52301823
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51509542
110TGF-beta signaling pathway_Homo sapiens_hsa043500.51280233
111Retinol metabolism_Homo sapiens_hsa008300.50344632
112Autoimmune thyroid disease_Homo sapiens_hsa053200.50021971
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49661038
114Endocytosis_Homo sapiens_hsa041440.48948682
115Chemical carcinogenesis_Homo sapiens_hsa052040.47849714
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46387689
117Choline metabolism in cancer_Homo sapiens_hsa052310.46351065
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45146295
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44148855
120Inositol phosphate metabolism_Homo sapiens_hsa005620.43858638
121Melanogenesis_Homo sapiens_hsa049160.42966862
122Hedgehog signaling pathway_Homo sapiens_hsa043400.41751308
123Prion diseases_Homo sapiens_hsa050200.41739395
124GnRH signaling pathway_Homo sapiens_hsa049120.41587936
125Rheumatoid arthritis_Homo sapiens_hsa053230.40704030
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40638996
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40410768
128beta-Alanine metabolism_Homo sapiens_hsa004100.40176465
129Vitamin digestion and absorption_Homo sapiens_hsa049770.39889173
130Wnt signaling pathway_Homo sapiens_hsa043100.38695812
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38096968
132MAPK signaling pathway_Homo sapiens_hsa040100.37618876
133Melanoma_Homo sapiens_hsa052180.34680669
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34251382
135Glucagon signaling pathway_Homo sapiens_hsa049220.33709833

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