PTPRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.64967238
2hemidesmosome assembly (GO:0031581)4.53711902
3bundle of His cell to Purkinje myocyte communication (GO:0086069)3.89170707
4semaphorin-plexin signaling pathway (GO:0071526)3.80557764
5COPI coating of Golgi vesicle (GO:0048205)3.76711474
6Golgi transport vesicle coating (GO:0048200)3.76711474
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75066175
8polarized epithelial cell differentiation (GO:0030859)3.72492797
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.59166409
10regulation of hippo signaling (GO:0035330)3.57516109
11regulation of cholesterol homeostasis (GO:2000188)3.57090284
12establishment of apical/basal cell polarity (GO:0035089)3.56067042
13intestinal cholesterol absorption (GO:0030299)3.50509389
14cell-substrate junction assembly (GO:0007044)3.38160167
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.35586426
16L-phenylalanine catabolic process (GO:0006559)3.35586426
17establishment or maintenance of monopolar cell polarity (GO:0061339)3.35078413
18establishment of monopolar cell polarity (GO:0061162)3.35078413
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26948658
20L-phenylalanine metabolic process (GO:0006558)3.26948658
21intestinal absorption (GO:0050892)3.22491281
22intestinal epithelial cell development (GO:0060576)3.21639101
23branching involved in salivary gland morphogenesis (GO:0060445)3.14425550
24epithelial cell differentiation involved in prostate gland development (GO:0060742)3.10523063
25sulfur amino acid catabolic process (GO:0000098)3.09422871
26embryonic retina morphogenesis in camera-type eye (GO:0060059)3.08731821
27gap junction assembly (GO:0016264)3.07974528
28cell-cell junction maintenance (GO:0045217)3.07806413
29adherens junction assembly (GO:0034333)3.02070894
30COPII vesicle coating (GO:0048208)2.98822977
31regulation of water loss via skin (GO:0033561)2.98332112
32cytoskeletal anchoring at plasma membrane (GO:0007016)2.96052785
33negative regulation of keratinocyte proliferation (GO:0010839)2.94723407
34cysteine metabolic process (GO:0006534)2.93672794
35branching involved in mammary gland duct morphogenesis (GO:0060444)2.92433146
36proline biosynthetic process (GO:0006561)2.91158768
37regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.89942159
38alpha-linolenic acid metabolic process (GO:0036109)2.89137200
39ectoderm development (GO:0007398)2.87083078
40establishment or maintenance of bipolar cell polarity (GO:0061245)2.86829154
41establishment or maintenance of apical/basal cell polarity (GO:0035088)2.86829154
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86807647
43asymmetric protein localization (GO:0008105)2.83402298
44endothelial cell chemotaxis (GO:0035767)2.83163373
454-hydroxyproline metabolic process (GO:0019471)2.81520940
46columnar/cuboidal epithelial cell development (GO:0002066)2.80610847
47positive regulation of hormone biosynthetic process (GO:0046886)2.80277719
48lateral sprouting from an epithelium (GO:0060601)2.79533509
49glandular epithelial cell differentiation (GO:0002067)2.78553433
50dorsal/ventral axis specification (GO:0009950)2.77479853
51cell-substrate adherens junction assembly (GO:0007045)2.76620972
52focal adhesion assembly (GO:0048041)2.76620972
53midgut development (GO:0007494)2.76322385
54anterior/posterior axis specification, embryo (GO:0008595)2.75762935
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74555890
56surfactant homeostasis (GO:0043129)2.71068106
57basement membrane organization (GO:0071711)2.70797800
58regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70315630
59activation of Rac GTPase activity (GO:0032863)2.70235089
60ear development (GO:0043583)2.70085661
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.69153562
62negative regulation of chondrocyte differentiation (GO:0032331)2.69010238
63notochord development (GO:0030903)2.68397562
64apical protein localization (GO:0045176)2.68135645
65activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.67955623
66endocrine pancreas development (GO:0031018)2.67029564
67paraxial mesoderm development (GO:0048339)2.64164008
68embryonic foregut morphogenesis (GO:0048617)2.63959259
69negative regulation of cholesterol transport (GO:0032375)2.63769793
70negative regulation of sterol transport (GO:0032372)2.63769793
71skin morphogenesis (GO:0043589)2.63076014
72exocrine pancreas development (GO:0031017)2.62417766
73multicellular organismal water homeostasis (GO:0050891)2.61805646
74negative regulation of cell fate specification (GO:0009996)2.61535295
75hormone catabolic process (GO:0042447)2.61488256
76regulation of gene silencing by RNA (GO:0060966)2.60321982
77regulation of posttranscriptional gene silencing (GO:0060147)2.60321982
78regulation of gene silencing by miRNA (GO:0060964)2.60321982
79atrioventricular valve morphogenesis (GO:0003181)2.59461435
80hippo signaling (GO:0035329)2.59226496
81regulation of cell fate specification (GO:0042659)2.58231050
82non-canonical Wnt signaling pathway (GO:0035567)2.56424279
83regulation of cholesterol biosynthetic process (GO:0045540)2.55773520
84negative regulation of fibrinolysis (GO:0051918)2.54223555
85biotin metabolic process (GO:0006768)2.54048374
86macroautophagy (GO:0016236)2.53794848
87high-density lipoprotein particle remodeling (GO:0034375)2.53310776
88establishment of skin barrier (GO:0061436)2.53056762
89aromatic amino acid family catabolic process (GO:0009074)2.52883267
90camera-type eye morphogenesis (GO:0048593)2.52451316
91cell junction maintenance (GO:0034331)2.52297021
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51790461
93homocysteine metabolic process (GO:0050667)2.51126565
94cell-cell junction assembly (GO:0007043)2.51091090
95triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.51058242
96positive regulation of nuclease activity (GO:0032075)2.50972533
97vitamin transmembrane transport (GO:0035461)2.50383093
98reverse cholesterol transport (GO:0043691)2.50074769
99peptidyl-glutamic acid carboxylation (GO:0017187)2.50030756
100protein carboxylation (GO:0018214)2.50030756
101regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.49926060
102proline metabolic process (GO:0006560)2.49893365
103protein retention in ER lumen (GO:0006621)2.49622420
104regulation of glucose import in response to insulin stimulus (GO:2001273)2.47956831
105urea metabolic process (GO:0019627)2.46955039
106urea cycle (GO:0000050)2.46955039
107renal system development (GO:0072001)2.45829849
108tight junction assembly (GO:0070830)2.45607239
109collecting duct development (GO:0072044)2.45013826
110glandular epithelial cell development (GO:0002068)2.44775285
111establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.44724044
112establishment of planar polarity (GO:0001736)2.44091655
113establishment of tissue polarity (GO:0007164)2.44091655
114dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.43922153
115maternal placenta development (GO:0001893)2.43659463
116negative regulation of fatty acid transport (GO:2000192)2.43621457
117epithelial cell fate commitment (GO:0072148)2.43316758
118epithelial cell-cell adhesion (GO:0090136)2.42776276
119type B pancreatic cell development (GO:0003323)2.42642637
120convergent extension (GO:0060026)2.38801040
121regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.38675903
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37919429
123regulation of fibrinolysis (GO:0051917)2.37319250
124apoptotic process involved in morphogenesis (GO:0060561)2.36398539
125G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.36192354
126chemical homeostasis within a tissue (GO:0048875)2.36026025
127adherens junction organization (GO:0034332)2.35820684
128positive regulation of hormone metabolic process (GO:0032352)2.35537571
129L-alpha-amino acid transmembrane transport (GO:1902475)2.34660505
130glyoxylate metabolic process (GO:0046487)2.34522624
131cell adhesion mediated by integrin (GO:0033627)2.34225226
132regulation of establishment of planar polarity (GO:0090175)2.34204213
133lung epithelium development (GO:0060428)2.34157365
134lung-associated mesenchyme development (GO:0060484)2.34143810
135gastrulation with mouth forming second (GO:0001702)2.33362656
136regulation of cardioblast differentiation (GO:0051890)2.33106610
137cell junction assembly (GO:0034329)2.32880154
138water homeostasis (GO:0030104)2.32686544
139serine family amino acid catabolic process (GO:0009071)2.32521810
140positive regulation of fatty acid beta-oxidation (GO:0032000)2.32493226
141oocyte development (GO:0048599)2.31329975
142regulation of catenin import into nucleus (GO:0035412)2.30344229
143phospholipid efflux (GO:0033700)2.29866024
144primary alcohol catabolic process (GO:0034310)2.29633252
145regulation of fatty acid beta-oxidation (GO:0031998)2.25617465
146negative regulation of catenin import into nucleus (GO:0035414)2.22930259
147cell junction organization (GO:0034330)2.22341688
148calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.22026174
149neuron projection extension involved in neuron projection guidance (GO:1902284)2.22018429
150axon extension involved in axon guidance (GO:0048846)2.22018429
151regulation of cholesterol metabolic process (GO:0090181)2.20489343
152positive regulation of smoothened signaling pathway (GO:0045880)2.20295700
153endothelial cell morphogenesis (GO:0001886)2.19608575
154peptidyl-tyrosine autophosphorylation (GO:0038083)2.17598311
155cochlea morphogenesis (GO:0090103)2.17505209
156regulation of transforming growth factor beta1 production (GO:0032908)2.17089876
157neural tube development (GO:0021915)2.13392000
158layer formation in cerebral cortex (GO:0021819)2.13088467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.04666333
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.02881070
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.13559074
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.06560035
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77411506
6* LXR_22158963_ChIP-Seq_LIVER_Mouse2.64695294
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.40583225
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.34282148
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15498995
10CLOCK_20551151_ChIP-Seq_293T_Human2.13317127
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.98077908
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96873158
13* ZNF263_19887448_ChIP-Seq_K562_Human1.94187320
14* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92197103
15* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.89819124
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89319683
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83159812
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82586971
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77475626
20* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75947278
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75298502
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75298502
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75298502
24* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71829362
25* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71081491
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64971817
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60943357
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.60826142
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58008723
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54821428
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.54159158
32AR_21909140_ChIP-Seq_LNCAP_Human1.53776389
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53663687
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.49040072
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.44835344
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44042090
37* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43275929
38* RUNX1_27514584_Chip-Seq_MCF-7_Human1.43118575
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43004936
40GATA6_25053715_ChIP-Seq_YYC3_Human1.41630478
41* ISL1_27105846_Chip-Seq_CPCs_Mouse1.39952255
42* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39850027
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38086700
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37627135
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35781089
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35272578
47* KDM2B_26808549_Chip-Seq_K562_Human1.35221509
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34895442
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34890997
50* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33883205
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33653810
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33176376
53AHR_22903824_ChIP-Seq_MCF-7_Human1.32549174
54CREB1_26743006_Chip-Seq_LNCaP_Human1.32022586
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31433352
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31170188
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.29182113
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29087294
59* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27531401
60SMC4_20622854_ChIP-Seq_HELA_Human1.26690052
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.26374282
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25988600
63GATA4_25053715_ChIP-Seq_YYC3_Human1.25914372
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25456284
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24384216
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24347152
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23903660
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21198912
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20969705
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19839588
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18815488
72TP53_22127205_ChIP-Seq_IMR90_Human1.18230386
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18159311
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17621510
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.15300772
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15293120
77ATF3_27146783_Chip-Seq_COLON_Human1.15273187
78* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14750241
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13022415
80* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12873251
81LXR_22292898_ChIP-Seq_THP-1_Human1.12813193
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12160669
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10162464
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09137670
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08357964
86TP63_22573176_ChIP-Seq_HFKS_Human1.08008782
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07808591
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.07620295
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.05503827
90* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05471068
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04524819
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04141853
93* SOX2_20726797_ChIP-Seq_SW620_Human1.02974624
94P68_20966046_ChIP-Seq_HELA_Human1.01813293
95KLF5_25053715_ChIP-Seq_YYC3_Human1.01804995
96* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01344636
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00841646
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00769786
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.00089205
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.99481510
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98612945
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97946938
103P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97025375
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96184783
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96099045
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96025154
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95725537
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.95276072
109GATA1_22025678_ChIP-Seq_K562_Human0.95052539
110* CTCF_27219007_Chip-Seq_Bcells_Human0.94757522
111* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94650523
112EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94619225
113RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94619225
114* CHD1_26751641_Chip-Seq_LNCaP_Human0.94117824
115* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94116154
116* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92737614
117* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92735755
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92562283
119* TCF7_22412390_ChIP-Seq_EML_Mouse0.92375013
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92199746
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92008166
122* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91965649
123* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90420342
124* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90420342
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89060533
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88878114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.33741847
2MP0002139_abnormal_hepatobiliary_system3.39997526
3MP0005360_urolithiasis2.99634541
4MP0000537_abnormal_urethra_morphology2.81972282
5MP0003283_abnormal_digestive_organ2.75885663
6MP0003705_abnormal_hypodermis_morpholog2.73156473
7MP0005085_abnormal_gallbladder_physiolo2.69817988
8MP0002796_impaired_skin_barrier2.64131106
9MP0005365_abnormal_bile_salt2.34635428
10MP0010030_abnormal_orbit_morphology2.30201271
11MP0005409_darkened_coat_color2.29868615
12MP0002254_reproductive_system_inflammat2.24728215
13MP0000566_synostosis2.18876069
14MP0003941_abnormal_skin_development2.18151332
15MP0000579_abnormal_nail_morphology2.13796281
16MP0003252_abnormal_bile_duct2.10206733
17MP0004264_abnormal_extraembryonic_tissu2.09617899
18MP0009053_abnormal_anal_canal2.02853091
19MP0001666_abnormal_nutrient_absorption1.95780553
20MP0005083_abnormal_biliary_tract1.94136756
21MP0001849_ear_inflammation1.87788341
22MP0005257_abnormal_intraocular_pressure1.85403168
23MP0010678_abnormal_skin_adnexa1.84945130
24MP0003195_calcinosis1.84562507
25MP0009780_abnormal_chondrocyte_physiolo1.80810197
26MP0000462_abnormal_digestive_system1.76613808
27MP0002098_abnormal_vibrissa_morphology1.76528926
28MP0005275_abnormal_skin_tensile1.75374969
29MP0003119_abnormal_digestive_system1.74989766
30MP0008875_abnormal_xenobiotic_pharmacok1.74761900
31MP0005248_abnormal_Harderian_gland1.61268757
32MP0000678_abnormal_parathyroid_gland1.60206843
33MP0000467_abnormal_esophagus_morphology1.58830784
34MP0002234_abnormal_pharynx_morphology1.57192175
35MP0004272_abnormal_basement_membrane1.50634436
36MP0000762_abnormal_tongue_morphology1.45730547
37MP0005501_abnormal_skin_physiology1.41991614
38MP0010329_abnormal_lipoprotein_level1.34875205
39MP0000383_abnormal_hair_follicle1.32506391
40MP0005623_abnormal_meninges_morphology1.31558693
41MP0002060_abnormal_skin_morphology1.30162676
42MP0002089_abnormal_postnatal_growth/wei1.29235168
43MP0003890_abnormal_embryonic-extraembry1.29059927
44MP0003115_abnormal_respiratory_system1.28377010
45* MP0004858_abnormal_nervous_system1.26402482
46MP0005670_abnormal_white_adipose1.25254533
47MP0005187_abnormal_penis_morphology1.25040786
48MP0002896_abnormal_bone_mineralization1.24749664
49MP0004019_abnormal_vitamin_homeostasis1.24481183
50MP0002909_abnormal_adrenal_gland1.23116569
51MP0003566_abnormal_cell_adhesion1.22287756
52MP0002877_abnormal_melanocyte_morpholog1.22238469
53MP0010352_gastrointestinal_tract_polyps1.21999615
54MP0002653_abnormal_ependyma_morphology1.19370058
55MP0005220_abnormal_exocrine_pancreas1.19312555
56MP0008438_abnormal_cutaneous_collagen1.17354705
57MP0000516_abnormal_urinary_system1.15687842
58MP0005367_renal/urinary_system_phenotyp1.15687842
59MP0004043_abnormal_pH_regulation1.15425885
60MP0002249_abnormal_larynx_morphology1.15174146
61MP0003315_abnormal_perineum_morphology1.13047956
62MP0004782_abnormal_surfactant_physiolog1.12716792
63MP0001944_abnormal_pancreas_morphology1.12314897
64MP0001216_abnormal_epidermal_layer1.11526766
65MP0000377_abnormal_hair_follicle1.10509474
66MP0000647_abnormal_sebaceous_gland1.09311095
67MP0002233_abnormal_nose_morphology1.08592141
68MP0002697_abnormal_eye_size1.08383028
69* MP0003942_abnormal_urinary_system1.08052849
70MP0003806_abnormal_nucleotide_metabolis1.07676092
71MP0005023_abnormal_wound_healing1.07380372
72MP0003453_abnormal_keratinocyte_physiol1.07332720
73MP0005666_abnormal_adipose_tissue1.06407229
74MP0001346_abnormal_lacrimal_gland1.04648332
75MP0009672_abnormal_birth_weight1.04060236
76MP0002138_abnormal_hepatobiliary_system0.98595121
77MP0001299_abnormal_eye_distance/0.94688035
78MP0000613_abnormal_salivary_gland0.94322812
79MP0008961_abnormal_basal_metabolism0.94313885
80MP0008789_abnormal_olfactory_epithelium0.93947361
81MP0000538_abnormal_urinary_bladder0.93188949
82MP0009384_cardiac_valve_regurgitation0.93126793
83MP0009379_abnormal_foot_pigmentation0.92690128
84MP0003937_abnormal_limbs/digits/tail_de0.91607588
85MP0000427_abnormal_hair_cycle0.91587659
86* MP0000627_abnormal_mammary_gland0.90642875
87* MP0000534_abnormal_ureter_morphology0.90219548
88MP0010771_integument_phenotype0.89678154
89MP0002111_abnormal_tail_morphology0.89629630
90MP0003300_gastrointestinal_ulcer0.88841238
91MP0005375_adipose_tissue_phenotype0.88764469
92MP0003123_paternal_imprinting0.88490016
93MP0004133_heterotaxia0.88260574
94MP0009840_abnormal_foam_cell0.86695592
95MP0010368_abnormal_lymphatic_system0.86598412
96MP0000428_abnormal_craniofacial_morphol0.86422443
97* MP0001340_abnormal_eyelid_morphology0.86396128
98MP0003878_abnormal_ear_physiology0.85774509
99MP0005377_hearing/vestibular/ear_phenot0.85774509
100MP0003385_abnormal_body_wall0.84422339
101* MP0002116_abnormal_craniofacial_bone0.83518736
102MP0003868_abnormal_feces_composition0.83034889
103MP0002084_abnormal_developmental_patter0.82493589
104MP0004197_abnormal_fetal_growth/weight/0.82404340
105MP0006138_congestive_heart_failure0.80604935
106MP0009703_decreased_birth_body0.80549143
107* MP0003935_abnormal_craniofacial_develop0.79937780
108MP0002092_abnormal_eye_morphology0.79928847
109MP0003122_maternal_imprinting0.78720724
110* MP0003755_abnormal_palate_morphology0.77579314
111MP0003091_abnormal_cell_migration0.77308790
112MP0002085_abnormal_embryonic_tissue0.77244951
113MP0002118_abnormal_lipid_homeostasis0.77122827
114MP0002282_abnormal_trachea_morphology0.75536774
115MP0005332_abnormal_amino_acid0.75372057
116* MP0003861_abnormal_nervous_system0.75080303
117MP0009643_abnormal_urine_homeostasis0.74509811
118MP0004185_abnormal_adipocyte_glucose0.73709210
119MP0000003_abnormal_adipose_tissue0.72901445
120* MP0005076_abnormal_cell_differentiation0.72387204
121MP0001348_abnormal_lacrimal_gland0.72290648
122MP0000432_abnormal_head_morphology0.71438979
123MP0000477_abnormal_intestine_morphology0.68972633
124MP0001730_embryonic_growth_arrest0.68818905
125MP0004233_abnormal_muscle_weight0.66789995
126MP0005451_abnormal_body_composition0.64242768
127MP0003329_amyloid_beta_deposits0.64115698
128MP0001188_hyperpigmentation0.63300346
129MP0009931_abnormal_skin_appearance0.63294805
130MP0000778_abnormal_nervous_system0.63274568

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)3.63568918
2Right ventricular cardiomyopathy (HP:0011663)3.59242700
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.54359113
4Flat acetabular roof (HP:0003180)3.49790311
5Milia (HP:0001056)3.37199155
6Fragile nails (HP:0001808)3.07749164
7Bronchomalacia (HP:0002780)2.99128399
8Deep venous thrombosis (HP:0002625)2.98275122
9Broad face (HP:0000283)2.90296653
10Turricephaly (HP:0000262)2.89902725
11Atrophic scars (HP:0001075)2.89494611
12Hyperinsulinemic hypoglycemia (HP:0000825)2.86410617
13Hyperacusis (HP:0010780)2.75460226
14Onycholysis (HP:0001806)2.73754374
15Hypoglycemic coma (HP:0001325)2.72726011
16Hypoplastic labia majora (HP:0000059)2.72584213
17Pterygium (HP:0001059)2.71700744
18Hypoglycemic seizures (HP:0002173)2.71099669
19Short nail (HP:0001799)2.69269330
20Xanthomatosis (HP:0000991)2.69204756
21Protrusio acetabuli (HP:0003179)2.61356258
22Abnormality of the distal phalanx of the thumb (HP:0009617)2.59930574
23Abnormality of aromatic amino acid family metabolism (HP:0004338)2.54062200
24Woolly hair (HP:0002224)2.52202632
25Cervical subluxation (HP:0003308)2.51139570
26Abnormality of the labia majora (HP:0012881)2.43231558
27Ulnar bowing (HP:0003031)2.42607353
28Premature rupture of membranes (HP:0001788)2.41931846
29Obstructive sleep apnea (HP:0002870)2.40376440
30Missing ribs (HP:0000921)2.39616478
31Abnormality of nail color (HP:0100643)2.33901538
32Late onset (HP:0003584)2.33326590
33Epidermoid cyst (HP:0200040)2.31773702
34Plantar hyperkeratosis (HP:0007556)2.31440401
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29735078
36Natal tooth (HP:0000695)2.29328196
37Gout (HP:0001997)2.26044965
38Hyperglycemia (HP:0003074)2.25177522
39Abnormality of carpal bone ossification (HP:0006257)2.23640185
40Abnormal hair laboratory examination (HP:0003328)2.21162864
41Malnutrition (HP:0004395)2.20704534
42Alopecia of scalp (HP:0002293)2.20061546
43Symptomatic seizures (HP:0011145)2.19642148
44Ankyloglossia (HP:0010296)2.18922793
45Shallow orbits (HP:0000586)2.17971268
46Hypobetalipoproteinemia (HP:0003563)2.15847729
47Selective tooth agenesis (HP:0001592)2.14539544
48Arterial tortuosity (HP:0005116)2.13941404
49Neonatal death (HP:0003811)2.12622904
50Abnormal ossification of hand bones (HP:0005921)2.11775845
51Abnormality of the pancreatic islet cells (HP:0006476)2.11741158
52Abnormality of endocrine pancreas physiology (HP:0012093)2.11741158
53Back pain (HP:0003418)2.10698132
54Hepatoblastoma (HP:0002884)2.09857402
55Ketoacidosis (HP:0001993)2.09838126
56Asymmetry of the thorax (HP:0001555)2.08358899
57Neonatal short-limb short stature (HP:0008921)2.07993854
58Cerebral aneurysm (HP:0004944)2.07907288
59Broad metatarsal (HP:0001783)2.07521733
60Abnormality of permanent molar morphology (HP:0011071)2.05332604
61Abnormality of the dental root (HP:0006486)2.05332604
62Taurodontia (HP:0000679)2.05332604
63Pseudobulbar signs (HP:0002200)2.05304912
64Pili torti (HP:0003777)2.04879891
65Germ cell neoplasia (HP:0100728)2.04666726
66Absent eyelashes (HP:0000561)1.94837312
67Renal duplication (HP:0000075)1.93961416
68Spinal cord compression (HP:0002176)1.93716542
69Fat malabsorption (HP:0002630)1.93502996
70Abnormality of molar morphology (HP:0011070)1.92834619
71Abnormality of molar (HP:0011077)1.92834619
72Abnormality of the salivary glands (HP:0010286)1.91689512
73Curly hair (HP:0002212)1.91450704
74Conjugated hyperbilirubinemia (HP:0002908)1.91196950
75Labial hypoplasia (HP:0000066)1.88855206
76Unilateral renal agenesis (HP:0000122)1.88724872
77Glomerulosclerosis (HP:0000096)1.88685101
78Shawl scrotum (HP:0000049)1.88594143
79Distal upper limb amyotrophy (HP:0007149)1.88046851
80Upper limb amyotrophy (HP:0009129)1.88046851
81Abnormality of the gastric mucosa (HP:0004295)1.86450630
82Abnormal vertebral ossification (HP:0100569)1.86118114
83Thin bony cortex (HP:0002753)1.86038529
84Vascular tortuosity (HP:0004948)1.84143455
85Abnormality of glutamine family amino acid metabolism (HP:0010902)1.83754307
86Facial shape deformation (HP:0011334)1.83488305
87Potter facies (HP:0002009)1.83488305
88Hypotrichosis (HP:0001006)1.81857110
89Long palpebral fissure (HP:0000637)1.81619185
90Partial duplication of thumb phalanx (HP:0009944)1.80792292
91Hypoplasia of dental enamel (HP:0006297)1.80619027
92Absent eyebrow (HP:0002223)1.80103442
93Abnormal pancreas size (HP:0012094)1.79857549
94Focal segmental glomerulosclerosis (HP:0000097)1.79754743
95Cutaneous finger syndactyly (HP:0010554)1.79559128
96Pancreatic islet-cell hyperplasia (HP:0004510)1.78770766
97Hemorrhage of the eye (HP:0011885)1.78413118
98Ketosis (HP:0001946)1.78165608
99Hyperactive renin-angiotensin system (HP:0000841)1.77829193
100Cerebral inclusion bodies (HP:0100314)1.75764457
101Vertebral clefting (HP:0008428)1.74615833
102Coronal craniosynostosis (HP:0004440)1.74513628
103Abnormality of the dental pulp (HP:0006479)1.74029474
104Abnormal hand bone ossification (HP:0010660)1.74005244
105Rectal prolapse (HP:0002035)1.73947749
106Acanthosis nigricans (HP:0000956)1.72551673
107Abnormality of the common coagulation pathway (HP:0010990)1.71009040
108Abnormality of the intrinsic pathway (HP:0010989)1.70429397
109Choanal stenosis (HP:0000452)1.70404347
110Esophageal atresia (HP:0002032)1.70093943
111Vertebral arch anomaly (HP:0008438)1.69786355
112Mildly elevated creatine phosphokinase (HP:0008180)1.69710225
113Bifid scrotum (HP:0000048)1.68870293
114Biliary tract neoplasm (HP:0100574)1.68087281
115Arnold-Chiari malformation (HP:0002308)1.67690004
116Renovascular hypertension (HP:0100817)1.67574284
117Deviation of the thumb (HP:0009603)1.67105917
118Advanced eruption of teeth (HP:0006288)1.66778887
119Spastic diplegia (HP:0001264)1.64969226
120Laryngomalacia (HP:0001601)1.64174438
121Hypolipoproteinemia (HP:0010981)1.64058906
122Tracheal stenosis (HP:0002777)1.63306144
123Aplasia involving bones of the extremities (HP:0009825)1.62684281
124Aplasia involving bones of the upper limbs (HP:0009823)1.62684281
125Aplasia of the phalanges of the hand (HP:0009802)1.62684281
126Lymphangioma (HP:0100764)1.62558997
127Fragile skin (HP:0001030)1.62220949
128Esophageal varix (HP:0002040)1.60705737
129Midface retrusion (HP:0011800)1.60182267
130Abnormality of dentin (HP:0010299)1.59868829
131Abnormality of the distal phalanges of the toes (HP:0010182)1.59711691
132Bicornuate uterus (HP:0000813)1.59692633
133Abnormal sex determination (HP:0012244)1.59538104
134Sex reversal (HP:0012245)1.59538104
135Abnormal biliary tract morphology (HP:0012440)1.59165749
136Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58822439
137Vertebral hypoplasia (HP:0008417)1.58822439
138Lip pit (HP:0100267)1.57939096
139Stridor (HP:0010307)1.57806010
140Abnormality of the lacrimal duct (HP:0011481)1.57748702
141Subacute progressive viral hepatitis (HP:0006572)1.56596120
142Hypoplastic female external genitalia (HP:0012815)1.56275112
143Long toe (HP:0010511)1.56086132
144Bowing of the arm (HP:0006488)1.56067489
145Bowed forearm bones (HP:0003956)1.56067489
146Abnormality of sulfur amino acid metabolism (HP:0004339)1.56034714
147Hand muscle atrophy (HP:0009130)1.55968485
148Nail dystrophy (HP:0008404)1.55629483
149Coxa vara (HP:0002812)1.55497421
150Congenital glaucoma (HP:0001087)1.55165928
151Hyperglycinuria (HP:0003108)1.55152895
152Palmoplantar hyperkeratosis (HP:0000972)1.54790722
153Abdominal distention (HP:0003270)1.54288753
154Hypotension (HP:0002615)1.54113834
155Hepatocellular carcinoma (HP:0001402)1.53604789
156Flattened epiphyses (HP:0003071)1.53203144
157Prolonged partial thromboplastin time (HP:0003645)1.53043338
158Hyperparathyroidism (HP:0000843)1.52947678
159Down-sloping shoulders (HP:0200021)1.52787912
160Cutaneous syndactyly (HP:0012725)1.52775795
161Thick nail (HP:0001805)1.52726073
162Abnormality of oral frenula (HP:0000190)1.52540627
163Chronic bronchitis (HP:0004469)1.50997184
164Rickets (HP:0002748)1.50392374
165Nephrolithiasis (HP:0000787)1.49606120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.79643077
2LATS13.26703758
3SMG12.99684808
4SIK12.83996104
5MAP3K22.64193029
6FER2.35013815
7EPHB22.31705700
8TRIB32.29054658
9PTK62.25318026
10CDK122.24999764
11INSRR2.16704680
12RIPK11.92934615
13PDGFRA1.90354473
14FRK1.88284976
15ERN11.87867753
16MET1.86180189
17PASK1.83233108
18FGFR21.80736404
19PKN21.80165755
20PTK21.76841776
21MST1R1.67822567
22LATS21.67661140
23MAP3K101.60342803
24MAPK151.56700742
25FGFR41.54728471
26ERBB21.52788171
27ICK1.49007887
28WNK41.45716069
29NTRK11.41741513
30STK38L1.40561845
31EEF2K1.40509185
32DDR21.37036151
33MTOR1.34933741
34MAP2K21.27932779
35CAMK1D1.27223855
36PRKD31.23557439
37CAMK1G1.22526092
38EPHA31.22380352
39FGFR11.21922737
40DAPK21.12813405
41LMTK21.10248664
42RPS6KB21.07140436
43AKT31.07030493
44PAK31.06489048
45TAOK31.06167563
46DYRK1B1.05986647
47PRKCI1.05907623
48MAP3K31.05237957
49IRAK31.04730824
50BCKDK1.00787771
51MAP3K90.95637035
52BCR0.95541850
53RET0.92039676
54EPHB10.90428055
55TYRO30.90044908
56KSR20.89929082
57HIPK20.88527189
58WNK30.88428741
59PAK40.86266057
60MAP3K10.83627504
61DMPK0.80692775
62CDC42BPA0.80044619
63CDK60.79979900
64LRRK20.79740129
65ERBB40.79616408
66PDGFRB0.79484857
67PRKD20.76818790
68PAK20.76467114
69MAP3K60.73857095
70RPS6KA20.72097243
71STK380.71987994
72TESK10.71389093
73GSK3A0.70828621
74BRAF0.69700497
75MARK20.68462680
76SCYL20.68013534
77BRD40.67459657
78NME10.66852293
79MAPKAPK30.63263185
80BMX0.62275014
81MAP2K10.60492975
82CDK70.56714985
83NEK60.55927556
84ARAF0.55839744
85CSNK1E0.55685286
86CSNK1A1L0.54383898
87FLT30.52136729
88KSR10.49484673
89FGFR30.49328714
90PRKG20.48713031
91MST40.48551197
92ALK0.47310891
93STK390.46930430
94TTK0.46221808
95ILK0.45730115
96STK30.44317611
97PRKCZ0.42734157
98PNCK0.42209745
99PDPK10.40874515
100TAOK10.39672023
101TTN0.39383330
102UHMK10.39341711
103RPS6KA10.38705684
104ROCK20.38556244
105SGK30.37754936
106CASK0.37470842
107MAP3K70.37105218
108CSNK1G20.36249705
109CSNK1G10.35859908
110NME20.35755986
111RPS6KC10.35358256
112RPS6KL10.35358256
113CSNK1D0.34424857
114PRKAA20.34277259
115WNK10.33622742
116ROCK10.33501687
117SGK4940.32018355
118SGK2230.32018355
119MARK10.31506107
120CAMK2G0.30340907
121PBK0.29492347
122EPHA40.28988828
123AKT20.28489319
124PRKD10.28451672
125MAP3K80.28413165
126ERBB30.28004983
127CAMK2B0.27446810
128DYRK20.27244381
129PRKAA10.26815102
130CHUK0.25899027
131PIK3CA0.25851787
132NEK20.25504265
133RPS6KB10.25143716
134SRC0.24515091

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.14213919
2Nitrogen metabolism_Homo sapiens_hsa009102.77654265
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.40016993
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39025743
5Sulfur metabolism_Homo sapiens_hsa009202.26098141
6Tryptophan metabolism_Homo sapiens_hsa003802.07630485
7Basal cell carcinoma_Homo sapiens_hsa052171.98566736
8Selenocompound metabolism_Homo sapiens_hsa004501.89600302
9Fat digestion and absorption_Homo sapiens_hsa049751.86097065
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69957900
11Bile secretion_Homo sapiens_hsa049761.68723627
12Arginine biosynthesis_Homo sapiens_hsa002201.68639840
13Fatty acid degradation_Homo sapiens_hsa000711.60469072
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59315361
15Histidine metabolism_Homo sapiens_hsa003401.59004222
16Hedgehog signaling pathway_Homo sapiens_hsa043401.56920478
17Hippo signaling pathway_Homo sapiens_hsa043901.55048110
18Butanoate metabolism_Homo sapiens_hsa006501.53521658
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47676328
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43864298
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42649351
22Phenylalanine metabolism_Homo sapiens_hsa003601.41706725
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41602919
24Lysine degradation_Homo sapiens_hsa003101.40642396
25Chemical carcinogenesis_Homo sapiens_hsa052041.37041648
26Fructose and mannose metabolism_Homo sapiens_hsa000511.35724283
27Bladder cancer_Homo sapiens_hsa052191.33993745
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30785863
29Tight junction_Homo sapiens_hsa045301.29135691
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27697323
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27620599
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27554973
33Fatty acid metabolism_Homo sapiens_hsa012121.25063025
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.24790188
35Protein digestion and absorption_Homo sapiens_hsa049741.21105450
36Vitamin B6 metabolism_Homo sapiens_hsa007501.19539850
37Complement and coagulation cascades_Homo sapiens_hsa046101.18861562
38PPAR signaling pathway_Homo sapiens_hsa033201.14300847
39* Adherens junction_Homo sapiens_hsa045201.14002984
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10568878
41Thyroid cancer_Homo sapiens_hsa052161.08914176
42ABC transporters_Homo sapiens_hsa020101.08775500
43Tyrosine metabolism_Homo sapiens_hsa003501.07363332
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06940479
45Retinol metabolism_Homo sapiens_hsa008301.06451656
46ECM-receptor interaction_Homo sapiens_hsa045121.05962760
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05323751
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04875281
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.00678842
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99700628
51Starch and sucrose metabolism_Homo sapiens_hsa005000.99170711
52Caffeine metabolism_Homo sapiens_hsa002320.98818054
53Endometrial cancer_Homo sapiens_hsa052130.95828386
54Insulin secretion_Homo sapiens_hsa049110.89438332
55Small cell lung cancer_Homo sapiens_hsa052220.89355703
56Melanogenesis_Homo sapiens_hsa049160.88217258
57Type II diabetes mellitus_Homo sapiens_hsa049300.87856614
58beta-Alanine metabolism_Homo sapiens_hsa004100.85765992
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85374272
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.84946654
61Fatty acid biosynthesis_Homo sapiens_hsa000610.83774267
62Peroxisome_Homo sapiens_hsa041460.83376859
63Renin-angiotensin system_Homo sapiens_hsa046140.83261938
64Pentose phosphate pathway_Homo sapiens_hsa000300.82934039
65ErbB signaling pathway_Homo sapiens_hsa040120.81298196
66* Insulin signaling pathway_Homo sapiens_hsa049100.79686606
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78739194
68Pyruvate metabolism_Homo sapiens_hsa006200.77379511
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77208137
70Chronic myeloid leukemia_Homo sapiens_hsa052200.76998565
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76006603
72Notch signaling pathway_Homo sapiens_hsa043300.75604016
73Steroid biosynthesis_Homo sapiens_hsa001000.75575952
74* Insulin resistance_Homo sapiens_hsa049310.73483696
75Propanoate metabolism_Homo sapiens_hsa006400.73447280
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.71882400
77Mineral absorption_Homo sapiens_hsa049780.71718458
78N-Glycan biosynthesis_Homo sapiens_hsa005100.71102812
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70275217
80TGF-beta signaling pathway_Homo sapiens_hsa043500.69640137
81Proteoglycans in cancer_Homo sapiens_hsa052050.69007946
82Wnt signaling pathway_Homo sapiens_hsa043100.68554786
83Sphingolipid metabolism_Homo sapiens_hsa006000.68518510
84Vibrio cholerae infection_Homo sapiens_hsa051100.68288145
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68060456
86Fatty acid elongation_Homo sapiens_hsa000620.66766476
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66679508
88Axon guidance_Homo sapiens_hsa043600.66176355
89Folate biosynthesis_Homo sapiens_hsa007900.65885280
90Dorso-ventral axis formation_Homo sapiens_hsa043200.65557656
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64354572
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63624309
93Carbon metabolism_Homo sapiens_hsa012000.63249021
94Prion diseases_Homo sapiens_hsa050200.62665649
95Thyroid hormone synthesis_Homo sapiens_hsa049180.62388776
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62378050
97Glucagon signaling pathway_Homo sapiens_hsa049220.62266494
98Vitamin digestion and absorption_Homo sapiens_hsa049770.61847967
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61728578
100Choline metabolism in cancer_Homo sapiens_hsa052310.61534630
101Renal cell carcinoma_Homo sapiens_hsa052110.60471717
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60255677
103Focal adhesion_Homo sapiens_hsa045100.59995110
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58863432
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58458840
106Amoebiasis_Homo sapiens_hsa051460.58088573
107VEGF signaling pathway_Homo sapiens_hsa043700.57329145
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56860070
109Estrogen signaling pathway_Homo sapiens_hsa049150.56786998
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.56779918
111Glioma_Homo sapiens_hsa052140.56028085
112AMPK signaling pathway_Homo sapiens_hsa041520.55621334
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.54768694
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54733042
115Arginine and proline metabolism_Homo sapiens_hsa003300.54671595
116Biosynthesis of amino acids_Homo sapiens_hsa012300.53714511
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53329906
118Pancreatic secretion_Homo sapiens_hsa049720.52946746
119Gap junction_Homo sapiens_hsa045400.52934297
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52362168
121GnRH signaling pathway_Homo sapiens_hsa049120.50944640
122Pathways in cancer_Homo sapiens_hsa052000.50088544
123mTOR signaling pathway_Homo sapiens_hsa041500.48411475
124Glycerolipid metabolism_Homo sapiens_hsa005610.47834934
125Glutathione metabolism_Homo sapiens_hsa004800.46912149
126Prostate cancer_Homo sapiens_hsa052150.46473684
127MicroRNAs in cancer_Homo sapiens_hsa052060.44433109
128Galactose metabolism_Homo sapiens_hsa000520.43034252

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