PTPRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)3.94655184
2layer formation in cerebral cortex (GO:0021819)3.81149595
3presynaptic membrane assembly (GO:0097105)3.65875639
4vascular endothelial growth factor signaling pathway (GO:0038084)3.57828178
5presynaptic membrane organization (GO:0097090)3.38598399
6regulation of axon extension involved in axon guidance (GO:0048841)3.32636115
7neuron recognition (GO:0008038)3.24269124
8axonal fasciculation (GO:0007413)3.24044157
9lymphangiogenesis (GO:0001946)3.15772349
10axon extension involved in axon guidance (GO:0048846)3.13699041
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.13699041
12hippo signaling (GO:0035329)3.11121705
13retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09483380
14regulation of axon guidance (GO:1902667)3.02904265
15positive regulation of SMAD protein import into nucleus (GO:0060391)3.00998023
16negative regulation of catenin import into nucleus (GO:0035414)2.95281759
17cell migration involved in sprouting angiogenesis (GO:0002042)2.95057162
18dendritic spine morphogenesis (GO:0060997)2.89295075
19regulation of gene silencing by RNA (GO:0060966)2.88967956
20regulation of posttranscriptional gene silencing (GO:0060147)2.88967956
21regulation of gene silencing by miRNA (GO:0060964)2.88967956
22anterior/posterior axis specification, embryo (GO:0008595)2.86833545
23peptidyl-tyrosine autophosphorylation (GO:0038083)2.86203137
24regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81329898
25negative regulation of axon extension involved in axon guidance (GO:0048843)2.78284747
26vocalization behavior (GO:0071625)2.77558414
27dorsal/ventral axis specification (GO:0009950)2.76026394
28establishment of nucleus localization (GO:0040023)2.75104135
29insulin-like growth factor receptor signaling pathway (GO:0048009)2.74612927
30notochord development (GO:0030903)2.74566827
31locomotory exploration behavior (GO:0035641)2.74432249
32pre-miRNA processing (GO:0031054)2.73877182
33dendrite morphogenesis (GO:0048813)2.69370980
34axon extension (GO:0048675)2.65986730
35convergent extension (GO:0060026)2.64664710
36artery development (GO:0060840)2.63200124
37cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62825322
38negative chemotaxis (GO:0050919)2.60896051
39glomerular filtration (GO:0003094)2.59283813
40basement membrane organization (GO:0071711)2.57489032
41renal filtration (GO:0097205)2.57021085
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56510403
43regulation of dendritic spine morphogenesis (GO:0061001)2.55198817
44vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54254542
45positive regulation of catenin import into nucleus (GO:0035413)2.52874032
46regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52088306
47plasma membrane repair (GO:0001778)2.51450960
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.50446637
49pyrimidine nucleobase catabolic process (GO:0006208)2.49238116
50regulation of cell fate specification (GO:0042659)2.48605622
51endothelial cell morphogenesis (GO:0001886)2.48167674
52embryonic foregut morphogenesis (GO:0048617)2.48061958
53endothelium development (GO:0003158)2.47547349
54postsynaptic membrane organization (GO:0001941)2.45142678
55cell migration in hindbrain (GO:0021535)2.44892473
56blood vessel endothelial cell migration (GO:0043534)2.44485513
57inner ear receptor cell development (GO:0060119)2.43104205
58regulation of transforming growth factor beta2 production (GO:0032909)2.42877381
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.42762881
60glomerular visceral epithelial cell development (GO:0072015)2.42268615
61negative regulation of axon guidance (GO:1902668)2.42217591
62patterning of blood vessels (GO:0001569)2.41955269
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.40330310
64regulation of translation, ncRNA-mediated (GO:0045974)2.40330310
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40330310
66lung-associated mesenchyme development (GO:0060484)2.39910891
67cell surface receptor signaling pathway involved in heart development (GO:0061311)2.38336344
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.36797125
69mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.36646900
70collagen fibril organization (GO:0030199)2.36409740
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35173575
72midgut development (GO:0007494)2.35064976
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.34500878
74proline transport (GO:0015824)2.32507923
75gastrulation with mouth forming second (GO:0001702)2.31692361
76regulation of SMAD protein import into nucleus (GO:0060390)2.31679959
77synaptic vesicle maturation (GO:0016188)2.31312927
78atrial cardiac muscle cell action potential (GO:0086014)2.30188048
79negative regulation of chondrocyte differentiation (GO:0032331)2.29868737
80ganglion development (GO:0061548)2.29559075
81innervation (GO:0060384)2.29362946
82regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29053003
83camera-type eye morphogenesis (GO:0048593)2.29003749
84positive regulation of axon extension (GO:0045773)2.27970304
85negative regulation of vascular permeability (GO:0043116)2.27953266
86neuron cell-cell adhesion (GO:0007158)2.27534046
87chondrocyte proliferation (GO:0035988)2.25205796
88limb bud formation (GO:0060174)2.24976666
89regulation of catenin import into nucleus (GO:0035412)2.24738549
90regulation of glutamate receptor signaling pathway (GO:1900449)2.24535061
91positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.23651197
92protein localization to synapse (GO:0035418)2.23524846
93retinal ganglion cell axon guidance (GO:0031290)2.23147894
94mitotic sister chromatid cohesion (GO:0007064)2.22588714
95outer ear morphogenesis (GO:0042473)2.21528236
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.20598582
97activation of protein kinase A activity (GO:0034199)2.20507984
98heart trabecula formation (GO:0060347)2.20380488
99polarized epithelial cell differentiation (GO:0030859)2.20002631
100neuron projection extension (GO:1990138)2.19730725
101cardiac muscle cell proliferation (GO:0060038)2.19428514
102synaptic vesicle docking involved in exocytosis (GO:0016081)2.19396497
103coronary vasculature morphogenesis (GO:0060977)2.18955251
104chemical homeostasis within a tissue (GO:0048875)2.18869306
105cell communication by electrical coupling (GO:0010644)2.18712228
106lateral sprouting from an epithelium (GO:0060601)2.18430987
107embryonic heart tube development (GO:0035050)2.17870589
108apical protein localization (GO:0045176)2.17807046
109central nervous system projection neuron axonogenesis (GO:0021952)2.17649616
110endothelial cell differentiation (GO:0045446)2.17300649
111heart morphogenesis (GO:0003007)2.16442568
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.16351421
113negative regulation of Rho protein signal transduction (GO:0035024)2.15772489
114positive regulation of synapse maturation (GO:0090129)2.14660762
115cell migration involved in gastrulation (GO:0042074)2.14323458
116membrane assembly (GO:0071709)2.14250246
117cell communication involved in cardiac conduction (GO:0086065)2.14153883
118semaphorin-plexin signaling pathway (GO:0071526)2.14025030
119glutamate secretion (GO:0014047)2.13218026
120metanephric mesenchyme development (GO:0072075)2.13197632
121ephrin receptor signaling pathway (GO:0048013)2.12989801
122embryonic retina morphogenesis in camera-type eye (GO:0060059)2.12481294
123dendritic spine organization (GO:0097061)2.12331698
124cardiac myofibril assembly (GO:0055003)2.12263505
125glomerular basement membrane development (GO:0032836)2.11623678
126renal system development (GO:0072001)2.10631561
127adherens junction assembly (GO:0034333)2.10346431
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.09855841
129mesenchymal-epithelial cell signaling (GO:0060638)2.09178835
130peripheral nervous system axon ensheathment (GO:0032292)2.08991199
131myelination in peripheral nervous system (GO:0022011)2.08991199
132exploration behavior (GO:0035640)2.08849141
133craniofacial suture morphogenesis (GO:0097094)2.08096195
134morphogenesis of an epithelial sheet (GO:0002011)2.07864098
135protein localization to endosome (GO:0036010)2.07730928
136surfactant homeostasis (GO:0043129)2.07651384
137regulation of cardioblast differentiation (GO:0051890)2.07547415
138gap junction assembly (GO:0016264)2.06745424
139kidney morphogenesis (GO:0060993)2.06713824
140cellular potassium ion homeostasis (GO:0030007)2.06365700
141negative regulation of keratinocyte proliferation (GO:0010839)2.06119812
142anterior/posterior axis specification (GO:0009948)2.05899018
143positive regulation of fatty acid beta-oxidation (GO:0032000)2.05291535
144regulation of endothelial cell differentiation (GO:0045601)2.04871535
145glomerular epithelial cell development (GO:0072310)2.04735879
146regulation of synapse structural plasticity (GO:0051823)2.04371216
147glial cell proliferation (GO:0014009)2.04322576
148glomerulus development (GO:0032835)2.03739339
149regulation of hippo signaling (GO:0035330)2.03652172
150olfactory bulb development (GO:0021772)2.03507144
151cochlea development (GO:0090102)2.03413522
152Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.02967232
153kidney mesenchyme development (GO:0072074)2.02680615
154dermatan sulfate biosynthetic process (GO:0030208)2.02654359
155substrate adhesion-dependent cell spreading (GO:0034446)2.02610785
156paraxial mesoderm development (GO:0048339)2.01853601
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.01661213
158appendage development (GO:0048736)2.01634161
159limb development (GO:0060173)2.01634161
160nuclear pore complex assembly (GO:0051292)2.00975862
161regulation of long-term neuronal synaptic plasticity (GO:0048169)2.00678665
162positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.99183744
163protein heterotrimerization (GO:0070208)1.99115841
164positive regulation of cardiac muscle tissue growth (GO:0055023)1.98365639
165bone trabecula formation (GO:0060346)1.97567216
166epithelial cell differentiation involved in kidney development (GO:0035850)1.97533511
167regulation of nephron tubule epithelial cell differentiation (GO:0072182)1.97390545
168female gonad development (GO:0008585)1.97210710
169regulation of neuron migration (GO:2001222)1.97062775
170regulation of establishment of planar polarity (GO:0090175)1.95523467
171positive regulation of cardiac muscle cell proliferation (GO:0060045)1.95328785
172non-canonical Wnt signaling pathway (GO:0035567)1.95136533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.44620329
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.45108992
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36624418
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33705351
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33705351
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24425299
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23597077
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.22991215
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22813952
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17584993
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15408739
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14013429
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12673933
14* GBX2_23144817_ChIP-Seq_PC3_Human2.10942752
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.04289254
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03090900
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99966270
18FUS_26573619_Chip-Seq_HEK293_Human1.95349893
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87683407
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86926955
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86734070
22* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86427009
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83749647
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.79758752
25* EP300_21415370_ChIP-Seq_HL-1_Mouse1.71764171
26* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69363137
27EWS_26573619_Chip-Seq_HEK293_Human1.64355693
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62702178
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62425072
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62201750
31AR_21572438_ChIP-Seq_LNCaP_Human1.59654777
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57889676
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.57828887
34* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57594829
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56166720
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56154653
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54722355
38DROSHA_22980978_ChIP-Seq_HELA_Human1.54591067
39AHR_22903824_ChIP-Seq_MCF-7_Human1.54427828
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52262138
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50413507
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49849908
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47964698
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47938644
45* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.47619468
46* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.47178354
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46719280
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46603153
49IGF1R_20145208_ChIP-Seq_DFB_Human1.46469211
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45647113
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45530581
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.43055672
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.43003195
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.39451011
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37422535
56TP53_16413492_ChIP-PET_HCT116_Human1.36301607
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.35925097
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.34677242
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34051554
60* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33698495
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.32652350
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32050215
63* SOX9_26525672_Chip-Seq_HEART_Mouse1.31011329
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30064901
65* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29917350
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29704932
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28993926
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.27685102
69AR_21909140_ChIP-Seq_LNCAP_Human1.26722583
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.26534706
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22489881
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22390034
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.21021761
74* CLOCK_20551151_ChIP-Seq_293T_Human1.20446725
75* CBX2_27304074_Chip-Seq_ESCs_Mouse1.19877440
76* WT1_19549856_ChIP-ChIP_CCG9911_Human1.19826027
77VDR_22108803_ChIP-Seq_LS180_Human1.19798265
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19714877
79TP53_18474530_ChIP-ChIP_U2OS_Human1.18308594
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.17960686
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.16997499
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16415056
83* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16218613
84* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16218613
85* RNF2_27304074_Chip-Seq_NSC_Mouse1.15763582
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.15526068
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.14965070
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.14916971
89* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14559238
90BCAT_22108803_ChIP-Seq_LS180_Human1.14539487
91* ERG_21242973_ChIP-ChIP_JURKAT_Human1.14491201
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.13657966
93KDM2B_26808549_Chip-Seq_K562_Human1.13571110
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.13017002
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12639452
96ZNF274_21170338_ChIP-Seq_K562_Hela1.12562348
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.12487828
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11707941
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11650847
100BRD4_25478319_ChIP-Seq_HGPS_Human1.11635823
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11615997
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.11328106
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10845854
104* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10503936
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10478770
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10032470
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09538683
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09367158
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09253844
110AR_19668381_ChIP-Seq_PC3_Human1.09200045
111* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07587769
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.06792104
113* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06420880
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05865918
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05736074
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05508574
117TAF15_26573619_Chip-Seq_HEK293_Human1.05247431
118* TCF4_23295773_ChIP-Seq_U87_Human1.05176410
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05053947
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05053947
121CJUN_26792858_Chip-Seq_BT549_Human1.04799087
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04771275
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03981375
124* P300_19829295_ChIP-Seq_ESCs_Human1.03631783
125* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03597908
126* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02912261
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02334843
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01977232
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01977232
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01741838
131* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01390976
132* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00741739
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97598138
134REST_21632747_ChIP-Seq_MESCs_Mouse0.96696641
135* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96515767
136RXR_22108803_ChIP-Seq_LS180_Human0.95660682
137* AR_25329375_ChIP-Seq_VCAP_Human0.94514217
138* STAT3_23295773_ChIP-Seq_U87_Human0.94478540
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.94440848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.30447361
2MP0010368_abnormal_lymphatic_system3.12645910
3MP0005623_abnormal_meninges_morphology3.04992048
4MP0003880_abnormal_central_pattern2.59863705
5MP0001879_abnormal_lymphatic_vessel2.48330338
6MP0004859_abnormal_synaptic_plasticity2.40222444
7MP0003705_abnormal_hypodermis_morpholog2.22678931
8MP0005167_abnormal_blood-brain_barrier2.01753917
9MP0000537_abnormal_urethra_morphology1.91620293
10MP0008438_abnormal_cutaneous_collagen1.86338235
11MP0000778_abnormal_nervous_system1.82086365
12MP0009780_abnormal_chondrocyte_physiolo1.80188771
13MP0006054_spinal_hemorrhage1.72177990
14MP0006138_congestive_heart_failure1.66592404
15MP0000534_abnormal_ureter_morphology1.62943040
16MP0001293_anophthalmia1.61669766
17MP0005187_abnormal_penis_morphology1.61348300
18MP0004084_abnormal_cardiac_muscle1.60760146
19MP0002254_reproductive_system_inflammat1.57637679
20MP0004270_analgesia1.54683746
21MP0003385_abnormal_body_wall1.54080765
22MP0009053_abnormal_anal_canal1.53382698
23MP0004858_abnormal_nervous_system1.53296392
24MP0000751_myopathy1.51915641
25MP0005257_abnormal_intraocular_pressure1.48669135
26MP0003635_abnormal_synaptic_transmissio1.46621380
27MP0010234_abnormal_vibrissa_follicle1.43107431
28MP0004215_abnormal_myocardial_fiber1.41785400
29MP0004484_altered_response_of1.41605815
30MP0003122_maternal_imprinting1.41084248
31MP0005503_abnormal_tendon_morphology1.40798945
32MP0002938_white_spotting1.40145840
33MP0003941_abnormal_skin_development1.39199877
34MP0005248_abnormal_Harderian_gland1.38816521
35MP0010030_abnormal_orbit_morphology1.36893481
36MP0005423_abnormal_somatic_nervous1.36133755
37MP0009384_cardiac_valve_regurgitation1.35312093
38MP0000428_abnormal_craniofacial_morphol1.32744711
39MP0000516_abnormal_urinary_system1.30789002
40MP0005367_renal/urinary_system_phenotyp1.30789002
41MP0003942_abnormal_urinary_system1.29400509
42MP0002108_abnormal_muscle_morphology1.25871582
43MP0005275_abnormal_skin_tensile1.25602797
44MP0003121_genomic_imprinting1.21657210
45MP0009250_abnormal_appendicular_skeleto1.20884577
46MP0002249_abnormal_larynx_morphology1.20420819
47* MP0002063_abnormal_learning/memory/cond1.20225067
48MP0002084_abnormal_developmental_patter1.18231721
49MP0001286_abnormal_eye_development1.18213135
50MP0003115_abnormal_respiratory_system1.17551146
51MP0003567_abnormal_fetal_cardiomyocyte1.17034549
52MP0004085_abnormal_heartbeat1.16881049
53MP0003935_abnormal_craniofacial_develop1.16844698
54MP0003119_abnormal_digestive_system1.15707827
55MP0004133_heterotaxia1.15624629
56MP0002837_dystrophic_cardiac_calcinosis1.14458498
57MP0001984_abnormal_olfaction1.13886481
58MP0009379_abnormal_foot_pigmentation1.11300674
59MP0003283_abnormal_digestive_organ1.10607849
60MP0004233_abnormal_muscle_weight1.10254912
61MP0010352_gastrointestinal_tract_polyps1.09243530
62MP0001958_emphysema1.07576945
63MP0003890_abnormal_embryonic-extraembry1.07205758
64MP0000432_abnormal_head_morphology1.06871886
65MP0003755_abnormal_palate_morphology1.05949145
66MP0001188_hyperpigmentation1.05180594
67MP0002295_abnormal_pulmonary_circulatio1.04995816
68MP0000566_synostosis1.04432013
69MP0003279_aneurysm1.04320336
70MP0009703_decreased_birth_body1.03966037
71MP0005620_abnormal_muscle_contractility1.03678704
72MP0002092_abnormal_eye_morphology1.02908034
73MP0002085_abnormal_embryonic_tissue0.99846446
74MP0000767_abnormal_smooth_muscle0.99437524
75MP0000462_abnormal_digestive_system0.99382819
76MP0004885_abnormal_endolymph0.99125785
77MP0000049_abnormal_middle_ear0.98949784
78MP0001177_atelectasis0.98251842
79MP0002896_abnormal_bone_mineralization0.98130894
80MP0009697_abnormal_copulation0.97689025
81MP0006276_abnormal_autonomic_nervous0.97571886
82MP0009672_abnormal_birth_weight0.97456808
83MP0002972_abnormal_cardiac_muscle0.97032125
84MP0003136_yellow_coat_color0.96928391
85MP0004145_abnormal_muscle_electrophysio0.96895098
86MP0002233_abnormal_nose_morphology0.96867918
87MP0002925_abnormal_cardiovascular_devel0.96778266
88MP0001299_abnormal_eye_distance/0.96251315
89MP0003091_abnormal_cell_migration0.96219517
90MP0002751_abnormal_autonomic_nervous0.94717856
91MP0002184_abnormal_innervation0.94491542
92MP0002111_abnormal_tail_morphology0.93976726
93MP0010630_abnormal_cardiac_muscle0.93941903
94MP0000733_abnormal_muscle_development0.93910467
95MP0004036_abnormal_muscle_relaxation0.93712074
96MP0000579_abnormal_nail_morphology0.93000331
97MP0003950_abnormal_plasma_membrane0.92675287
98MP0003828_pulmonary_edema0.92533605
99MP0006292_abnormal_olfactory_placode0.91344992
100MP0008775_abnormal_heart_ventricle0.90391279
101MP0008932_abnormal_embryonic_tissue0.90151060
102MP0002127_abnormal_cardiovascular_syste0.89646316
103MP0005330_cardiomyopathy0.89417096
104MP0003861_abnormal_nervous_system0.88529347
105MP0001529_abnormal_vocalization0.88507054
106MP0003937_abnormal_limbs/digits/tail_de0.88192045
107MP0004130_abnormal_muscle_cell0.87987545
108MP0003137_abnormal_impulse_conducting0.87887076
109MP0000762_abnormal_tongue_morphology0.86644479
110MP0002081_perinatal_lethality0.86295584
111MP0005595_abnormal_vascular_smooth0.85518473
112MP0002932_abnormal_joint_morphology0.85395174
113MP0004087_abnormal_muscle_fiber0.85020828
114MP0005385_cardiovascular_system_phenoty0.84503143
115MP0001544_abnormal_cardiovascular_syste0.84503143
116MP0005394_taste/olfaction_phenotype0.83972576
117MP0005499_abnormal_olfactory_system0.83972576
118MP0009745_abnormal_behavioral_response0.81668429
119MP0002234_abnormal_pharynx_morphology0.81555149
120MP0005391_vision/eye_phenotype0.81092401
121MP0005508_abnormal_skeleton_morphology0.80921040
122MP0001915_intracranial_hemorrhage0.80322551
123MP0000631_abnormal_neuroendocrine_gland0.80006715
124MP0002282_abnormal_trachea_morphology0.79980933
125MP0008789_abnormal_olfactory_epithelium0.79902466
126MP0000013_abnormal_adipose_tissue0.79639529
127MP0002114_abnormal_axial_skeleton0.78736453
128* MP0001486_abnormal_startle_reflex0.78666873
129MP0002116_abnormal_craniofacial_bone0.78588788
130MP0003566_abnormal_cell_adhesion0.78297973
131MP0005171_absent_coat_pigmentation0.77655482
132MP0001672_abnormal_embryogenesis/_devel0.77259353
133MP0005380_embryogenesis_phenotype0.77259353
134MP0000955_abnormal_spinal_cord0.77131170
135MP0002128_abnormal_blood_circulation0.76796382
136MP0008057_abnormal_DNA_replication0.76708547
137* MP0002572_abnormal_emotion/affect_behav0.76499977
138MP0003045_fibrosis0.76121663
139MP0005197_abnormal_uvea_morphology0.76038485
140MP0002109_abnormal_limb_morphology0.76036335
141MP0002152_abnormal_brain_morphology0.75293312
142MP0002697_abnormal_eye_size0.75173461
143MP0005409_darkened_coat_color0.74346805
144MP0002064_seizures0.71437448
145* MP0002734_abnormal_mechanical_nocicepti0.69826389
146MP0000266_abnormal_heart_morphology0.69406298

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.49304910
2Lymphangioma (HP:0100764)2.91360478
3Broad metatarsal (HP:0001783)2.90902620
4Short 4th metacarpal (HP:0010044)2.80934980
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.80934980
6Protrusio acetabuli (HP:0003179)2.73830135
7Hepatoblastoma (HP:0002884)2.60607326
8Abnormality of the 4th metacarpal (HP:0010012)2.57924570
9Cerebral aneurysm (HP:0004944)2.56265682
10Bifid tongue (HP:0010297)2.49641750
11Cortical dysplasia (HP:0002539)2.36017420
12Soft skin (HP:0000977)2.34478502
13Buphthalmos (HP:0000557)2.32913972
14Overgrowth (HP:0001548)2.31978439
15Neonatal short-limb short stature (HP:0008921)2.19608575
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15613629
17Coronal craniosynostosis (HP:0004440)2.15192096
18Abnormality of the lower motor neuron (HP:0002366)2.14832385
19Colon cancer (HP:0003003)2.11971502
20Myelomeningocele (HP:0002475)2.10935100
21Skull defect (HP:0001362)2.09897664
22Premature rupture of membranes (HP:0001788)2.07968136
23Bronchomalacia (HP:0002780)2.05822612
24Morphological abnormality of the middle ear (HP:0008609)2.04121349
25Focal seizures (HP:0007359)2.00375787
26Abnormality of dentin (HP:0010299)1.99490487
27Arterial tortuosity (HP:0005116)1.98838802
28Venous insufficiency (HP:0005293)1.97628278
29Mitral valve prolapse (HP:0001634)1.97158659
30Shawl scrotum (HP:0000049)1.95214238
31Aortic aneurysm (HP:0004942)1.94923841
32Vertebral arch anomaly (HP:0008438)1.94680078
33Termporal pattern (HP:0011008)1.93907622
34Insidious onset (HP:0003587)1.93907622
35Wide anterior fontanel (HP:0000260)1.93570586
36Midline defect of the nose (HP:0004122)1.91708266
37Vascular tortuosity (HP:0004948)1.91341614
38Hydroureter (HP:0000072)1.90564341
39Right ventricular cardiomyopathy (HP:0011663)1.90456144
40Cutaneous finger syndactyly (HP:0010554)1.89651870
41Sudden death (HP:0001699)1.89395980
42Hyperventilation (HP:0002883)1.89194347
43Choanal stenosis (HP:0000452)1.88455621
44Vitreoretinal degeneration (HP:0000655)1.88271695
45Aortic dissection (HP:0002647)1.87994549
46Difficulty running (HP:0009046)1.87010558
47Renal hypoplasia (HP:0000089)1.86565943
48Enlarged penis (HP:0000040)1.86396539
49Increased connective tissue (HP:0009025)1.86278856
50Adactyly (HP:0009776)1.84798444
51Action tremor (HP:0002345)1.81556503
52Aneurysm (HP:0002617)1.80348166
53Abnormal lung lobation (HP:0002101)1.78972008
54Omphalocele (HP:0001539)1.78237243
55Short hallux (HP:0010109)1.77766410
56Aplasia involving bones of the extremities (HP:0009825)1.76865165
57Aplasia involving bones of the upper limbs (HP:0009823)1.76865165
58Aplasia of the phalanges of the hand (HP:0009802)1.76865165
59Anophthalmia (HP:0000528)1.75586590
60Renal duplication (HP:0000075)1.74792697
61Turricephaly (HP:0000262)1.74772411
62Atrophic scars (HP:0001075)1.74706448
63Increased variability in muscle fiber diameter (HP:0003557)1.73810554
64Broad long bones (HP:0005622)1.73591154
65Volvulus (HP:0002580)1.73243742
66Subacute progressive viral hepatitis (HP:0006572)1.73056135
67Abnormality of the labia minora (HP:0012880)1.72403941
68Venous abnormality (HP:0002624)1.72294755
69Chorioretinal atrophy (HP:0000533)1.72213812
70Hypoplastic ischia (HP:0003175)1.71891103
71Pulmonic stenosis (HP:0001642)1.70377713
72Vaginal atresia (HP:0000148)1.70188552
73Abnormality of the ischium (HP:0003174)1.69602717
74Esophageal varix (HP:0002040)1.69359161
75Supranuclear gaze palsy (HP:0000605)1.69088176
76Bowel diverticulosis (HP:0005222)1.68980640
77Amblyopia (HP:0000646)1.68189472
78Genital tract atresia (HP:0001827)1.66871157
79Hyporeflexia of lower limbs (HP:0002600)1.66256106
80Wrist flexion contracture (HP:0001239)1.65388223
81Septo-optic dysplasia (HP:0100842)1.64590440
82Hypoplasia of the iris (HP:0007676)1.64390060
83Focal motor seizures (HP:0011153)1.63470139
84Bladder diverticulum (HP:0000015)1.63414623
85Drooling (HP:0002307)1.63080344
86Excessive salivation (HP:0003781)1.63080344
87Macroorchidism (HP:0000053)1.62100096
88Arnold-Chiari malformation (HP:0002308)1.61813837
89High anterior hairline (HP:0009890)1.61493402
90Visceral angiomatosis (HP:0100761)1.61174991
91Exotropia (HP:0000577)1.61065327
92Absent eyebrow (HP:0002223)1.60902697
93Ankle contracture (HP:0006466)1.60419502
94Intestinal atresia (HP:0011100)1.58893032
95Rectal prolapse (HP:0002035)1.58488474
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.56590308
97Ankyloglossia (HP:0010296)1.56443794
98Abnormality of the nasal septum (HP:0000419)1.56054800
99Papillary thyroid carcinoma (HP:0002895)1.55907004
100Deviation of the hallux (HP:0010051)1.55581346
101Aplasia/Hypoplasia of the hallux (HP:0008362)1.55571990
102Broad phalanx (HP:0006009)1.55335819
103Abnormality of the calf musculature (HP:0001430)1.55030044
104Deep venous thrombosis (HP:0002625)1.54881108
105Embryonal renal neoplasm (HP:0011794)1.53621154
106Absent frontal sinuses (HP:0002688)1.53464454
107Germ cell neoplasia (HP:0100728)1.52556179
108Atonic seizures (HP:0010819)1.51903382
109Facial cleft (HP:0002006)1.51814876
110Asymmetry of the thorax (HP:0001555)1.51808432
111Hip contracture (HP:0003273)1.51789021
112Narrow palate (HP:0000189)1.51084451
113Hemangiomatosis (HP:0007461)1.50243283
114Spinal rigidity (HP:0003306)1.50209795
115Hyperextensible skin (HP:0000974)1.50125857
116Cutaneous syndactyly (HP:0012725)1.49874514
117Hematochezia (HP:0002573)1.49780961
118Genetic anticipation (HP:0003743)1.49745472
119Muscle fiber splitting (HP:0003555)1.49665032
120Abnormality of the pubic bones (HP:0003172)1.49407743
121Follicular hyperkeratosis (HP:0007502)1.48769269
122Aqueductal stenosis (HP:0002410)1.48762115
123Preaxial foot polydactyly (HP:0001841)1.48446463
124Astrocytoma (HP:0009592)1.47770585
125Abnormality of the astrocytes (HP:0100707)1.47770585
126Atrial fibrillation (HP:0005110)1.47711273
127Limited hip movement (HP:0008800)1.47458596
128Broad thumb (HP:0011304)1.46660718
129Micropenis (HP:0000054)1.46215740
130Nephroblastoma (Wilms tumor) (HP:0002667)1.46096214
131Absent eyelashes (HP:0000561)1.45455319
132Decreased muscle mass (HP:0003199)1.44808157
133Facial shape deformation (HP:0011334)1.44439601
134Potter facies (HP:0002009)1.44439601
135Increased nuchal translucency (HP:0010880)1.44365001
136Hallux valgus (HP:0001822)1.43863339
137Hypoplastic nipples (HP:0002557)1.43688213
138Hyperthyroidism (HP:0000836)1.43445450
139Primary atrial arrhythmia (HP:0001692)1.43292478
140Renovascular hypertension (HP:0100817)1.42900352
141Broad toe (HP:0001837)1.42510294
142Supernumerary spleens (HP:0009799)1.42213495
143Transitional cell carcinoma of the bladder (HP:0006740)1.41893736
144Abnormality of the antihelix (HP:0009738)1.41524256
145Gastrointestinal carcinoma (HP:0002672)1.41022805
146Malignant gastrointestinal tract tumors (HP:0006749)1.41022805
147Broad finger (HP:0001500)1.39893678
148Tracheal stenosis (HP:0002777)1.39135628
149Bilateral microphthalmos (HP:0007633)1.38844335
150Ulnar bowing (HP:0003031)1.38741215
151Bicornuate uterus (HP:0000813)1.38336899
152Chronic hepatic failure (HP:0100626)1.37263097
153Intellectual disability, moderate (HP:0002342)1.36399440
154Large earlobe (HP:0009748)1.35028930
155Wormian bones (HP:0002645)1.35023668
156Labial hypoplasia (HP:0000066)1.34558124
157Dental crowding (HP:0000678)1.34232500
158Trigonocephaly (HP:0000243)1.32912167
159Short humerus (HP:0005792)1.32027784
160Fibular hypoplasia (HP:0003038)1.31751817
161Cupped ear (HP:0000378)1.31580396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.07062176
2TNIK2.94254908
3LATS12.54095179
4MKNK22.43149988
5WNK32.40086620
6LATS22.37792189
7EPHA42.27100202
8EPHB22.25074544
9MARK12.23245491
10RIPK12.16048013
11DDR22.06876478
12NTRK32.04936558
13KDR2.00585715
14PDGFRA2.00128560
15MKNK11.78952419
16FER1.78156978
17MAP3K41.75242308
18PRKD31.69871764
19TSSK61.68152397
20PAK61.65249483
21BMPR1B1.64624204
22CAMK1G1.63417920
23TTK1.47593541
24MAP3K91.47042406
25FGFR21.45960177
26PTK2B1.44151463
27TYRO31.43809024
28DMPK1.39759967
29CDC71.37469645
30PAK31.36632806
31TRIM281.34389423
32NTRK11.34044852
33PLK31.29239650
34PHKG21.28223157
35PHKG11.28223157
36AKT31.28105213
37NTRK21.28042747
38MAP2K41.26969756
39MINK11.24009775
40LMTK21.23393088
41TAF11.23022642
42CAMK1D1.22649507
43SIK11.21470985
44TTN1.20013947
45SRPK11.18654336
46INSRR1.18515149
47NUAK11.18295078
48FRK1.18210776
49PNCK1.18113256
50KSR11.17938175
51TGFBR21.11060085
52PTK21.10583841
53SIK21.09259245
54TRIB31.06218068
55DAPK21.04660608
56STK31.03447473
57KSR21.02562067
58DYRK21.01188307
59PLK41.00718255
60MYLK0.97128142
61PDK20.97108646
62CSNK1G10.95453714
63PLK20.95177782
64BRD40.91940466
65MAP3K20.91284556
66RET0.91188023
67ICK0.88624512
68STK380.86738683
69BRSK20.86167850
70PBK0.86064376
71CASK0.83995842
72PTK60.83222898
73NEK10.81504212
74WEE10.81421726
75FGFR10.80235822
76ZAK0.79027499
77PDGFRB0.78323094
78ACVR1B0.77836849
79DYRK30.77275052
80CDK50.76613087
81NLK0.76166508
82BMX0.75054336
83MAP3K100.74465725
84STK390.74056945
85ROCK10.73889452
86TGFBR10.72334118
87PAK20.71885850
88MAP3K60.71792603
89ERBB40.71237538
90ERBB20.68011422
91SGK2230.66833573
92SGK4940.66833573
93MAPK130.66404621
94MAP2K10.65585674
95PLK10.65443530
96SGK20.65376371
97GRK50.64644877
98ERBB30.64576280
99CAMK2A0.63628970
100PRKCH0.63562668
101MTOR0.63391609
102CSNK1G20.62895826
103STK38L0.62440994
104PRKCE0.62181474
105MELK0.60156700
106SGK30.58949223
107CSNK1A1L0.58467701
108MARK20.57870271
109OBSCN0.57769967
110PRKD10.57720533
111BCR0.57579036
112MAP2K70.57355167
113NEK20.55735005
114CAMK40.55039845
115STK110.55003285
116PRKCZ0.54239292
117PKN20.54048611
118CDC42BPA0.53695855
119CAMKK10.53376992
120FGFR30.53346146
121ATM0.53022825
122PRKCG0.52425754
123ROCK20.51907019
124PDK30.51582606
125PDK40.51582606
126PIK3CA0.51228926
127EEF2K0.51218076
128FLT30.51191692
129GSK3A0.50779160
130DYRK1A0.50684485
131MAPK120.50163781
132CDK120.48661283
133MAP3K70.46958716
134WNK40.46675159
135MET0.46455477
136PRKAA20.46278390
137CSNK1G30.44668447
138PINK10.44388019
139PRKDC0.43940092
140OXSR10.41393857
141CHEK20.40711955
142CDK180.39809697
143BUB10.38847058
144CSNK1E0.37973196

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.42105223
2Axon guidance_Homo sapiens_hsa043601.83061175
3Adherens junction_Homo sapiens_hsa045201.79790500
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72138781
5Nicotine addiction_Homo sapiens_hsa050331.64865192
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62055723
7ECM-receptor interaction_Homo sapiens_hsa045121.57514268
8Dilated cardiomyopathy_Homo sapiens_hsa054141.56566651
9Circadian entrainment_Homo sapiens_hsa047131.52185280
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49447796
11Steroid biosynthesis_Homo sapiens_hsa001001.49171709
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47323587
13Focal adhesion_Homo sapiens_hsa045101.44795856
14GABAergic synapse_Homo sapiens_hsa047271.43424062
15Non-homologous end-joining_Homo sapiens_hsa034501.42828657
16Glutamatergic synapse_Homo sapiens_hsa047241.42703229
17Renin secretion_Homo sapiens_hsa049241.40305611
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40258306
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40085873
20Propanoate metabolism_Homo sapiens_hsa006401.38608968
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38450304
22Long-term potentiation_Homo sapiens_hsa047201.38260247
23Melanogenesis_Homo sapiens_hsa049161.37487425
24Hippo signaling pathway_Homo sapiens_hsa043901.36617962
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35640051
26Salivary secretion_Homo sapiens_hsa049701.35277883
27Basal cell carcinoma_Homo sapiens_hsa052171.34699079
28Bile secretion_Homo sapiens_hsa049761.34467711
29Gastric acid secretion_Homo sapiens_hsa049711.33505089
30Gap junction_Homo sapiens_hsa045401.32599217
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30851886
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26917293
33Dorso-ventral axis formation_Homo sapiens_hsa043201.25955946
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24440502
35Morphine addiction_Homo sapiens_hsa050321.20371734
36Insulin secretion_Homo sapiens_hsa049111.20264701
37Amphetamine addiction_Homo sapiens_hsa050311.19403751
38Estrogen signaling pathway_Homo sapiens_hsa049151.18987009
39Dopaminergic synapse_Homo sapiens_hsa047281.15925337
40Vitamin B6 metabolism_Homo sapiens_hsa007501.15913610
41Oxytocin signaling pathway_Homo sapiens_hsa049211.14902434
42Cholinergic synapse_Homo sapiens_hsa047251.14747669
43Arginine biosynthesis_Homo sapiens_hsa002201.14024577
44Tight junction_Homo sapiens_hsa045301.13113694
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12169088
46Rap1 signaling pathway_Homo sapiens_hsa040151.11081179
47Glioma_Homo sapiens_hsa052141.10231139
48Hedgehog signaling pathway_Homo sapiens_hsa043401.09446921
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07066093
50Wnt signaling pathway_Homo sapiens_hsa043101.06701635
51Proteoglycans in cancer_Homo sapiens_hsa052051.05304364
52GnRH signaling pathway_Homo sapiens_hsa049121.05221199
53Cell cycle_Homo sapiens_hsa041101.04997255
54TGF-beta signaling pathway_Homo sapiens_hsa043501.02926087
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02673966
56Olfactory transduction_Homo sapiens_hsa047401.02222324
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01701075
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01690673
59cAMP signaling pathway_Homo sapiens_hsa040241.01079603
60Taste transduction_Homo sapiens_hsa047420.98092752
61Long-term depression_Homo sapiens_hsa047300.97091301
62Calcium signaling pathway_Homo sapiens_hsa040200.95346084
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.92703195
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92441741
65Ovarian steroidogenesis_Homo sapiens_hsa049130.91093717
66Endometrial cancer_Homo sapiens_hsa052130.89709288
67Protein digestion and absorption_Homo sapiens_hsa049740.89667049
68Basal transcription factors_Homo sapiens_hsa030220.88896003
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88840607
70Cocaine addiction_Homo sapiens_hsa050300.88694696
71Pyruvate metabolism_Homo sapiens_hsa006200.87528588
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85972044
73Renal cell carcinoma_Homo sapiens_hsa052110.85902747
74Selenocompound metabolism_Homo sapiens_hsa004500.85715495
75Protein export_Homo sapiens_hsa030600.85319305
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84792417
77Glucagon signaling pathway_Homo sapiens_hsa049220.82677655
78Synaptic vesicle cycle_Homo sapiens_hsa047210.82449127
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81076863
80Type II diabetes mellitus_Homo sapiens_hsa049300.80956303
81PPAR signaling pathway_Homo sapiens_hsa033200.80657419
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79637811
83ErbB signaling pathway_Homo sapiens_hsa040120.78805348
84Amoebiasis_Homo sapiens_hsa051460.78706966
85Fatty acid biosynthesis_Homo sapiens_hsa000610.78564130
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.78460810
87Oocyte meiosis_Homo sapiens_hsa041140.78163019
88Serotonergic synapse_Homo sapiens_hsa047260.78107602
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76753192
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75803467
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74804434
92mRNA surveillance pathway_Homo sapiens_hsa030150.73067545
93Thyroid hormone synthesis_Homo sapiens_hsa049180.72456065
94Melanoma_Homo sapiens_hsa052180.72317518
95Choline metabolism in cancer_Homo sapiens_hsa052310.72111425
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71536424
97Fanconi anemia pathway_Homo sapiens_hsa034600.71365895
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71106271
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.71087837
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71015910
101Ras signaling pathway_Homo sapiens_hsa040140.70852813
102MicroRNAs in cancer_Homo sapiens_hsa052060.70726593
103Colorectal cancer_Homo sapiens_hsa052100.69912120
104mTOR signaling pathway_Homo sapiens_hsa041500.69017817
105Butanoate metabolism_Homo sapiens_hsa006500.68950498
106RNA transport_Homo sapiens_hsa030130.68756115
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66405242
108Fatty acid metabolism_Homo sapiens_hsa012120.65872371
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65626693
110Mismatch repair_Homo sapiens_hsa034300.64788540
111Lysine degradation_Homo sapiens_hsa003100.64620793
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64361700
113AMPK signaling pathway_Homo sapiens_hsa041520.63282401
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63079759
115Notch signaling pathway_Homo sapiens_hsa043300.62936726
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62437151
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62173295
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61606998
119Insulin resistance_Homo sapiens_hsa049310.61286502
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.61234305
121VEGF signaling pathway_Homo sapiens_hsa043700.61182408
122Pathways in cancer_Homo sapiens_hsa052000.60450765
123Insulin signaling pathway_Homo sapiens_hsa049100.58687305
124Cardiac muscle contraction_Homo sapiens_hsa042600.58579314
125Small cell lung cancer_Homo sapiens_hsa052220.58457691
126Circadian rhythm_Homo sapiens_hsa047100.57065039
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56669101
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52340134
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50958436
130Thyroid cancer_Homo sapiens_hsa052160.50577666
131Prostate cancer_Homo sapiens_hsa052150.48588273
132RNA degradation_Homo sapiens_hsa030180.46864863
133Fatty acid degradation_Homo sapiens_hsa000710.46549317
134Phototransduction_Homo sapiens_hsa047440.44770459
135Alcoholism_Homo sapiens_hsa050340.44125653

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