PTPRH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.62183462
2angiotensin maturation (GO:0002003)9.32140663
3bile acid and bile salt transport (GO:0015721)6.57451455
4maintenance of gastrointestinal epithelium (GO:0030277)6.14460726
5actin filament depolymerization (GO:0030042)6.12454500
6vitamin A metabolic process (GO:0006776)5.89885030
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.89599581
8bundle of His cell to Purkinje myocyte communication (GO:0086069)5.78819953
9epoxygenase P450 pathway (GO:0019373)5.37673612
10flavonoid metabolic process (GO:0009812)5.37344838
11purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.36077229
123-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.36077229
13sulfate transmembrane transport (GO:1902358)5.34610443
14NADH metabolic process (GO:0006734)5.30782341
15digestive system process (GO:0022600)5.30578457
16fat-soluble vitamin biosynthetic process (GO:0042362)5.09154034
17regulation of bile acid biosynthetic process (GO:0070857)4.99083775
18UDP-N-acetylglucosamine metabolic process (GO:0006047)4.90248142
19virion attachment to host cell (GO:0019062)4.86349640
20adhesion of symbiont to host cell (GO:0044650)4.86349640
21epithelial structure maintenance (GO:0010669)4.78623317
22drug catabolic process (GO:0042737)4.74340886
23sulfur compound transport (GO:0072348)4.65942422
24cellular glucuronidation (GO:0052695)4.65680274
25positive regulation of guanylate cyclase activity (GO:0031284)4.59666026
26cellular response to hepatocyte growth factor stimulus (GO:0035729)4.52563744
27response to hepatocyte growth factor (GO:0035728)4.52563744
28glucuronate metabolic process (GO:0019585)4.49727429
29uronic acid metabolic process (GO:0006063)4.49727429
30sulfate transport (GO:0008272)4.38162517
31regulation of systemic arterial blood pressure (GO:0003073)4.34352414
32phospholipid efflux (GO:0033700)4.31910732
33fructose metabolic process (GO:0006000)4.31864086
34urea cycle (GO:0000050)4.23096455
35desmosome organization (GO:0002934)4.20548691
36digestion (GO:0007586)4.18320935
37vitamin transmembrane transport (GO:0035461)4.17445204
38lipoprotein transport (GO:0042953)4.12106892
39glucose 6-phosphate metabolic process (GO:0051156)4.08807435
40pyrimidine-containing compound transmembrane transport (GO:0072531)4.07942613
41intestinal epithelial cell development (GO:0060576)4.07907649
42urea metabolic process (GO:0019627)4.07196077
43drug metabolic process (GO:0017144)4.04972939
44O-glycan processing (GO:0016266)4.02854448
45plasma lipoprotein particle organization (GO:0071827)4.01727976
46modified amino acid transport (GO:0072337)4.00574594
47protein-lipid complex remodeling (GO:0034368)3.99864277
48macromolecular complex remodeling (GO:0034367)3.99864277
49plasma lipoprotein particle remodeling (GO:0034369)3.99864277
50high-density lipoprotein particle remodeling (GO:0034375)3.96686233
51adhesion of symbiont to host (GO:0044406)3.89458607
52lipoprotein metabolic process (GO:0042157)3.86773420
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.84495047
54protein-lipid complex subunit organization (GO:0071825)3.83448174
55oligosaccharide catabolic process (GO:0009313)3.80036362
56plasma lipoprotein particle assembly (GO:0034377)3.79087601
57thyroid hormone metabolic process (GO:0042403)3.78222584
58peptide hormone processing (GO:0016486)3.76420604
59arginine metabolic process (GO:0006525)3.69666349
60low-density lipoprotein particle remodeling (GO:0034374)3.67380920
61receptor guanylyl cyclase signaling pathway (GO:0007168)3.67134250
62renal system process involved in regulation of blood volume (GO:0001977)3.66076108
63regulation of triglyceride catabolic process (GO:0010896)3.66050495
64negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.65748046
65hormone catabolic process (GO:0042447)3.65517518
66nitrogen cycle metabolic process (GO:0071941)3.64656187
67regulation of cGMP biosynthetic process (GO:0030826)3.62046849
68protein-lipid complex assembly (GO:0065005)3.61757658
69bicarbonate transport (GO:0015701)3.61654107
70regulation of viral release from host cell (GO:1902186)3.61483828
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.61422579
72phosphatidylcholine biosynthetic process (GO:0006656)3.60896673
73positive regulation of lipoprotein lipase activity (GO:0051006)3.59261356
74positive regulation of triglyceride lipase activity (GO:0061365)3.59261356
75cytidine catabolic process (GO:0006216)3.59038825
76cytidine deamination (GO:0009972)3.59038825
77cytidine metabolic process (GO:0046087)3.59038825
78drug transmembrane transport (GO:0006855)3.58675502
79sulfation (GO:0051923)3.56891198
80regulation of cholesterol esterification (GO:0010872)3.56246152
81bile acid metabolic process (GO:0008206)3.56072157
82glucocorticoid biosynthetic process (GO:0006704)3.55992021
83negative regulation of protein tyrosine kinase activity (GO:0061099)3.54789513
84glutamine family amino acid biosynthetic process (GO:0009084)3.53698149
85reverse cholesterol transport (GO:0043691)3.52960170
86regulation of cellular extravasation (GO:0002691)3.51835242
87renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.50916449
88phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.48872102
89positive regulation of glycoprotein biosynthetic process (GO:0010560)3.48675382
90glycolipid catabolic process (GO:0019377)3.48290906
91thrombin receptor signaling pathway (GO:0070493)3.46596088
92very-low-density lipoprotein particle assembly (GO:0034379)3.46447515
93striated muscle atrophy (GO:0014891)3.46280975
94cholesterol homeostasis (GO:0042632)3.46129787
95ethanol oxidation (GO:0006069)3.44824008
96sterol homeostasis (GO:0055092)3.42420320
97regulation of cholesterol metabolic process (GO:0090181)3.42079078
98drinking behavior (GO:0042756)3.41821485
99drug transport (GO:0015893)3.38098563
100proline biosynthetic process (GO:0006561)3.37086206
101diacylglycerol metabolic process (GO:0046339)3.36393962
102positive regulation of pseudopodium assembly (GO:0031274)3.35822387
103proline metabolic process (GO:0006560)3.33756052
104regulation of cholesterol homeostasis (GO:2000188)3.33307048
105negative regulation of keratinocyte proliferation (GO:0010839)3.33056550
106positive regulation of lipid catabolic process (GO:0050996)3.32347247
107glycosphingolipid catabolic process (GO:0046479)3.31735549
108homocysteine metabolic process (GO:0050667)3.31539770
109calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.30955597
110sperm capacitation (GO:0048240)3.30017468
111cholesterol efflux (GO:0033344)3.26081361
112response to hydroperoxide (GO:0033194)3.25830046
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25554393
114positive regulation of glycoprotein metabolic process (GO:1903020)3.23118275
115regulation of guanylate cyclase activity (GO:0031282)3.18385193
116regulation of vitamin metabolic process (GO:0030656)3.17993829
117hemidesmosome assembly (GO:0031581)3.17603100
118negative regulation of sterol transport (GO:0032372)3.16314932
119negative regulation of cholesterol transport (GO:0032375)3.16314932
120regulation of actin nucleation (GO:0051125)3.07771199
121complement activation, classical pathway (GO:0006958)3.05337658
122regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.01313236
123endocrine process (GO:0050886)3.01313236
124regulation of systemic arterial blood pressure by hormone (GO:0001990)3.01313236
125sphingomyelin metabolic process (GO:0006684)3.01262931
126skeletal muscle adaptation (GO:0043501)3.01140991
127transcytosis (GO:0045056)3.00526726
128sterol transport (GO:0015918)2.99769357
129cholesterol transport (GO:0030301)2.99769357
130nucleobase catabolic process (GO:0046113)2.96768145
131regulation of pseudopodium assembly (GO:0031272)2.95590630
132sodium ion homeostasis (GO:0055078)2.94621207
133positive regulation of triglyceride metabolic process (GO:0090208)2.91929487
134glycerol metabolic process (GO:0006071)2.91492627
135ventricular cardiac muscle cell action potential (GO:0086005)2.91207405
136vitamin transport (GO:0051180)2.90035391
137positive regulation of T cell differentiation in thymus (GO:0033089)2.89348407
138antibacterial humoral response (GO:0019731)2.87209148
139exogenous drug catabolic process (GO:0042738)2.86455396
140cell communication involved in cardiac conduction (GO:0086065)2.86368195
141muscle atrophy (GO:0014889)2.84429493
142antimicrobial humoral response (GO:0019730)2.84384007
143neurotransmitter biosynthetic process (GO:0042136)2.81520095
144peptide catabolic process (GO:0043171)2.81417767
145transepithelial transport (GO:0070633)2.77661394
146regulation of protein glycosylation (GO:0060049)2.76471321
147alkaloid metabolic process (GO:0009820)2.76210787
148intestinal absorption (GO:0050892)10.3270443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.14908881
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.95207884
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.48096319
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.75676288
5* SOX2_20726797_ChIP-Seq_SW620_Human2.70855481
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.64165100
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.59292897
8* GATA4_25053715_ChIP-Seq_YYC3_Human2.51602390
9* GATA6_25053715_ChIP-Seq_YYC3_Human2.49036271
10ZNF263_19887448_ChIP-Seq_K562_Human2.36812061
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28254557
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26758061
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24892698
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23113883
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.13370665
16LXR_22158963_ChIP-Seq_LIVER_Mouse1.92080217
17KLF5_25053715_ChIP-Seq_YYC3_Human1.90242627
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.90015120
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.87671545
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87578695
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81735473
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78308752
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.73177894
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72442393
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69505844
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66409104
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60915358
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60554559
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.60396226
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59585404
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55472140
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53453868
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51691999
34* RUNX1_27514584_Chip-Seq_MCF-7_Human1.50991600
35RACK7_27058665_Chip-Seq_MCF-7_Human1.49194048
36VDR_22108803_ChIP-Seq_LS180_Human1.48034744
37* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45207280
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.45116157
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43892706
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35521907
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.35253204
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34934875
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32017110
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30496446
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29401966
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28808725
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28094985
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26872658
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26328176
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25045659
51* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24856583
52DROSHA_22980978_ChIP-Seq_HELA_Human1.24126767
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23386261
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23253879
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.23149508
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22420793
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18594204
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17939165
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16565562
60* ATF3_27146783_Chip-Seq_COLON_Human1.16413989
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.15376757
62SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14253103
63JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14119410
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13050225
65* GATA2_19941826_ChIP-Seq_K562_Human1.12374507
66CLOCK_20551151_ChIP-Seq_293T_Human1.09401298
67CREB1_26743006_Chip-Seq_LNCaP_Human1.09221998
68BCOR_27268052_Chip-Seq_Bcells_Human1.09076590
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08989912
70* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08896980
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08401108
72EGR1_19032775_ChIP-ChIP_M12_Human1.06714087
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.06466397
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05347330
75* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04796591
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04209991
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03644749
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03541836
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01257487
80GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01030543
81* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00983484
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00961480
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00556301
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00343219
85BCL6_27268052_Chip-Seq_Bcells_Human1.00227847
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99137250
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99033466
88GATA1_22025678_ChIP-Seq_K562_Human0.98178265
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97576947
90FOXA2_19822575_ChIP-Seq_HepG2_Human0.97237435
91CTCF_27219007_Chip-Seq_Bcells_Human0.97123400
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96831684
93CDX2_22108803_ChIP-Seq_LS180_Human0.96355475
94SA1_27219007_Chip-Seq_Bcells_Human0.96262129
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93521619
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92726509
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92726509
98LXR_22292898_ChIP-Seq_THP-1_Human0.92273486
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92044757
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.91661943
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91395445
102SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90479970
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89962249
104CEBPB_22108803_ChIP-Seq_LS180_Human0.89570447
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88836291
106AR_21909140_ChIP-Seq_LNCAP_Human0.88297146
107* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88103928
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.87040286
109FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86394147
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86323140
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85706959
112* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83575066
113TP63_22573176_ChIP-Seq_HFKS_Human0.83483281
114* FOXA1_25552417_ChIP-Seq_VCAP_Human0.82553043
115GATA1_19941826_ChIP-Seq_K562_Human0.81890797
116RXR_22108803_ChIP-Seq_LS180_Human0.80911760
117IRF8_22096565_ChIP-ChIP_GC-B_Human0.80418566
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80406063
119ETS1_21867929_ChIP-Seq_TH2_Mouse0.80402723
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80352872
121NANOG_20526341_ChIP-Seq_ESCs_Human0.80323490
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79767185
123PHF8_20622854_ChIP-Seq_HELA_Human0.79578654
124E2F1_20622854_ChIP-Seq_HELA_Human0.78996067
125MYC_19915707_ChIP-ChIP_AK7_Human0.77629864
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.77273102
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75318315
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73864218
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73849991
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73179815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.59913646
2MP0005360_urolithiasis7.35131635
3MP0001666_abnormal_nutrient_absorption5.44198573
4MP0002822_catalepsy3.66370077
5MP0004264_abnormal_extraembryonic_tissu3.60922330
6MP0003866_abnormal_defecation3.33484522
7MP0003878_abnormal_ear_physiology3.16317221
8MP0005377_hearing/vestibular/ear_phenot3.16317221
9MP0005085_abnormal_gallbladder_physiolo3.09987403
10MP0000462_abnormal_digestive_system3.08004653
11MP0008875_abnormal_xenobiotic_pharmacok2.79076021
12MP0002139_abnormal_hepatobiliary_system2.65527751
13MP0003252_abnormal_bile_duct2.59123661
14MP0001873_stomach_inflammation2.41362771
15MP0003183_abnormal_peptide_metabolism2.36785558
16MP0009840_abnormal_foam_cell2.36744913
17MP0001663_abnormal_digestive_system2.23114395
18MP0005409_darkened_coat_color2.22627307
19MP0005381_digestive/alimentary_phenotyp2.18469126
20MP0001664_abnormal_digestion2.09620988
21MP0010329_abnormal_lipoprotein_level2.07254000
22MP0003283_abnormal_digestive_organ2.03873515
23MP0010155_abnormal_intestine_physiology1.88389377
24MP0000477_abnormal_intestine_morphology1.85105153
25MP0004019_abnormal_vitamin_homeostasis1.73693229
26MP0003705_abnormal_hypodermis_morpholog1.71761202
27MP0005670_abnormal_white_adipose1.69108719
28MP0000490_abnormal_crypts_of1.67125088
29MP0002796_impaired_skin_barrier1.63132081
30MP0010352_gastrointestinal_tract_polyps1.62022884
31MP0000537_abnormal_urethra_morphology1.61670285
32MP0000566_synostosis1.60739230
33MP0004147_increased_porphyrin_level1.60228027
34MP0010678_abnormal_skin_adnexa1.57571207
35MP0005167_abnormal_blood-brain_barrier1.57244154
36MP0005365_abnormal_bile_salt1.56998168
37MP0004043_abnormal_pH_regulation1.54351346
38MP0000538_abnormal_urinary_bladder1.49558400
39MP0003191_abnormal_cellular_cholesterol1.44254380
40MP0005084_abnormal_gallbladder_morpholo1.40229464
41MP0003300_gastrointestinal_ulcer1.37271026
42MP0005257_abnormal_intraocular_pressure1.36072235
43MP0001764_abnormal_homeostasis1.33931177
44MP0003315_abnormal_perineum_morphology1.32189370
45MP0002876_abnormal_thyroid_physiology1.30961946
46MP0004947_skin_inflammation1.23405725
47MP0004858_abnormal_nervous_system1.23172800
48MP0002138_abnormal_hepatobiliary_system1.17628093
49MP0009643_abnormal_urine_homeostasis1.10574103
50MP0009053_abnormal_anal_canal1.09371940
51MP0001849_ear_inflammation1.06793557
52MP0003879_abnormal_hair_cell1.05653958
53MP0008872_abnormal_physiological_respon1.05634251
54MP0006054_spinal_hemorrhage1.05244678
55MP0001765_abnormal_ion_homeostasis1.04884702
56MP0003329_amyloid_beta_deposits1.02961323
57MP0005448_abnormal_energy_balance1.02825830
58MP0001188_hyperpigmentation1.00370985
59MP0003195_calcinosis0.96027189
60MP0005310_abnormal_salivary_gland0.95980215
61MP0004270_analgesia0.94504962
62MP0002098_abnormal_vibrissa_morphology0.94491405
63MP0005501_abnormal_skin_physiology0.94325766
64MP0003453_abnormal_keratinocyte_physiol0.93775105
65MP0004185_abnormal_adipocyte_glucose0.93142203
66MP0005058_abnormal_lysosome_morphology0.91266434
67MP0003868_abnormal_feces_composition0.90620697
68MP0002118_abnormal_lipid_homeostasis0.89126529
69MP0005166_decreased_susceptibility_to0.88327459
70MP0003806_abnormal_nucleotide_metabolis0.87259570
71MP0000467_abnormal_esophagus_morphology0.86219707
72MP0002971_abnormal_brown_adipose0.85112364
73MP0009115_abnormal_fat_cell0.83463555
74MP0000470_abnormal_stomach_morphology0.81118472
75MP0002909_abnormal_adrenal_gland0.80850383
76MP0005636_abnormal_mineral_homeostasis0.79795182
77MP0003953_abnormal_hormone_level0.78834798
78MP0003950_abnormal_plasma_membrane0.78497160
79MP0001216_abnormal_epidermal_layer0.78080150
80MP0005083_abnormal_biliary_tract0.75047033
81MP0002089_abnormal_postnatal_growth/wei0.74049557
82MP0009379_abnormal_foot_pigmentation0.73114047
83MP0003045_fibrosis0.72675025
84MP0008004_abnormal_stomach_pH0.71638302
85MP0002254_reproductive_system_inflammat0.70696502
86MP0005451_abnormal_body_composition0.68835323
87MP0000609_abnormal_liver_physiology0.68819632
88MP0003122_maternal_imprinting0.68033599
89MP0002234_abnormal_pharynx_morphology0.67983930
90MP0002078_abnormal_glucose_homeostasis0.67300049
91MP0003385_abnormal_body_wall0.65270849
92MP0005666_abnormal_adipose_tissue0.64304808
93MP0005535_abnormal_body_temperature0.64073944
94MP0009780_abnormal_chondrocyte_physiolo0.63621998
95MP0005332_abnormal_amino_acid0.61911916
96MP0002896_abnormal_bone_mineralization0.61741699
97MP0000230_abnormal_systemic_arterial0.61374767
98MP0003941_abnormal_skin_development0.60424539
99MP0008873_increased_physiological_sensi0.58804621
100MP0005334_abnormal_fat_pad0.57949774
101MP0002136_abnormal_kidney_physiology0.56148133
102MP0005319_abnormal_enzyme/_coenzyme0.55801107
103MP0005408_hypopigmentation0.54642737
104MP0000377_abnormal_hair_follicle0.53918780
105MP0000598_abnormal_liver_morphology0.53832324
106MP0000604_amyloidosis0.52807648
107MP0009384_cardiac_valve_regurgitation0.52062187
108MP0009785_altered_susceptibility_to0.51881299
109MP0008469_abnormal_protein_level0.51786596
110MP0000383_abnormal_hair_follicle0.50827313
111MP0005367_renal/urinary_system_phenotyp0.47285465
112MP0000516_abnormal_urinary_system0.47285465
113MP0000249_abnormal_blood_vessel0.47270489
114MP0000678_abnormal_parathyroid_gland0.45930516
115MP0003718_maternal_effect0.45406984
116MP0005076_abnormal_cell_differentiation0.45369877
117MP0009642_abnormal_blood_homeostasis0.45127064
118MP0005266_abnormal_metabolism0.44934144
119MP0001845_abnormal_inflammatory_respons0.44323214
120MP0002060_abnormal_skin_morphology0.42943483
121MP0004782_abnormal_surfactant_physiolog0.42593404
122MP0001756_abnormal_urination0.42105974
123MP0003123_paternal_imprinting0.42016889
124MP0000639_abnormal_adrenal_gland0.41622276
125MP0005584_abnormal_enzyme/coenzyme_acti0.41323658
126MP0005395_other_phenotype0.40654761
127MP0000681_abnormal_thyroid_gland0.40348156
128MP0002277_abnormal_respiratory_mucosa0.40190708
129MP0002166_altered_tumor_susceptibility0.39599071
130MP0002970_abnormal_white_adipose0.39555343
131MP0002132_abnormal_respiratory_system0.39426083
132MP0008775_abnormal_heart_ventricle0.39261980
133MP0005023_abnormal_wound_healing0.38368425
134MP0001501_abnormal_sleep_pattern0.38137925
135MP0010771_integument_phenotype0.37422560
136MP0001485_abnormal_pinna_reflex0.36800781

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.50031086
2Malnutrition (HP:0004395)6.55287664
3Right ventricular cardiomyopathy (HP:0011663)6.37200182
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.41868240
5Flat acetabular roof (HP:0003180)5.23326881
6Acanthocytosis (HP:0001927)5.14468036
7Cupped ribs (HP:0000887)4.85571015
8Hypobetalipoproteinemia (HP:0003563)4.56836215
9Villous atrophy (HP:0011473)4.38335605
10Abnormality of small intestinal villus morphology (HP:0011472)4.38335605
11Abdominal distention (HP:0003270)4.26759604
12Hydroxyprolinuria (HP:0003080)4.17959069
13Abnormality of proline metabolism (HP:0010907)4.17959069
14Systemic lupus erythematosus (HP:0002725)4.14747522
15Conjugated hyperbilirubinemia (HP:0002908)4.12889842
16Hemorrhage of the eye (HP:0011885)4.06940164
17Chronic diarrhea (HP:0002028)3.93884206
18Pustule (HP:0200039)3.72010144
19Autoimmune thrombocytopenia (HP:0001973)3.70842904
20Decreased circulating renin level (HP:0003351)3.68840451
21Complement deficiency (HP:0004431)3.67682427
22Deep venous thrombosis (HP:0002625)3.67436500
23Hyperactive renin-angiotensin system (HP:0000841)3.63759694
24Widely patent fontanelles and sutures (HP:0004492)3.45571755
25Fat malabsorption (HP:0002630)3.43183543
26Abnormality of the 1st metacarpal (HP:0010009)3.35770786
27Pili torti (HP:0003777)3.32069791
28Dehydration (HP:0001944)3.27855459
29Proximal tubulopathy (HP:0000114)3.23291379
30Alkalosis (HP:0001948)3.23102977
31Confusion (HP:0001289)3.21279777
32Abnormality of the distal phalanx of the thumb (HP:0009617)3.20341467
33Abnormality of complement system (HP:0005339)3.20293013
34Abnormal tarsal ossification (HP:0008369)3.18093705
35Glomerulonephritis (HP:0000099)3.17706256
36Hypolipoproteinemia (HP:0010981)3.13380215
37Woolly hair (HP:0002224)3.08068988
38Mildly elevated creatine phosphokinase (HP:0008180)3.06002176
39Progressive sensorineural hearing impairment (HP:0000408)3.01872714
40Gastrointestinal dysmotility (HP:0002579)2.98870683
41Poikilocytosis (HP:0004447)2.97882039
42Epidermoid cyst (HP:0200040)2.94398466
43Metabolic alkalosis (HP:0200114)2.93924435
44Steatorrhea (HP:0002570)2.93747064
45Focal segmental glomerulosclerosis (HP:0000097)2.93501565
46Pigmentary retinal degeneration (HP:0001146)2.93193195
47Autoimmune hemolytic anemia (HP:0001890)2.92863644
48Fragile nails (HP:0001808)2.89805542
49Alopecia of scalp (HP:0002293)2.85596696
50Prostate neoplasm (HP:0100787)2.83720071
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79143809
52Milia (HP:0001056)2.77044686
53Abnormality of serine family amino acid metabolism (HP:0010894)2.75182854
54Abnormality of glycine metabolism (HP:0010895)2.75182854
55Xanthomatosis (HP:0000991)2.73684187
56Symphalangism affecting the phalanges of the hand (HP:0009773)2.73451384
57Hyperammonemia (HP:0001987)2.68869180
58Increased purine levels (HP:0004368)2.67763683
59Hyperuricemia (HP:0002149)2.67763683
60Intrahepatic cholestasis (HP:0001406)2.64551367
61Hypotension (HP:0002615)2.62659157
62Abnormality of chloride homeostasis (HP:0011422)2.62608726
63Flattened epiphyses (HP:0003071)2.62137064
64Gout (HP:0001997)2.62096001
65Neonatal short-limb short stature (HP:0008921)2.61725307
66Abnormality of carpal bone ossification (HP:0006257)2.59581485
67Nausea (HP:0002018)2.59076033
68Hyperaldosteronism (HP:0000859)2.58911067
69Potter facies (HP:0002009)2.57856667
70Facial shape deformation (HP:0011334)2.57856667
71Glomerulosclerosis (HP:0000096)2.57014135
72Progressive hearing impairment (HP:0001730)2.51417743
73Abnormal biliary tract morphology (HP:0012440)2.50717771
74Prolonged partial thromboplastin time (HP:0003645)2.49867005
75Palpitations (HP:0001962)2.47483439
76Myopathic facies (HP:0002058)2.47446026
77Hypophosphatemia (HP:0002148)2.46583995
78Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45014308
79Hoarse voice (HP:0001609)2.43471339
80Abnormality of the vitamin B12 metabolism (HP:0004341)2.37527650
81Megaloblastic anemia (HP:0001889)2.34852393
82Hypercholesterolemia (HP:0003124)2.33262643
83Biliary tract neoplasm (HP:0100574)2.28452436
84Syncope (HP:0001279)2.23610039
85Short phalanx of the thumb (HP:0009660)2.22510424
86Abnormality of vitamin B metabolism (HP:0004340)2.20917270
87Cone-rod dystrophy (HP:0000548)2.20582045
88Late onset (HP:0003584)2.20486175
89Nephritis (HP:0000123)2.19275210
90Cerebral palsy (HP:0100021)2.19147372
91Abnormal foot bone ossification (HP:0010675)2.18896507
92Vascular calcification (HP:0004934)2.18681388
93Curly hair (HP:0002212)2.16477127
94Glycosuria (HP:0003076)2.16142948
95Abnormality of urine glucose concentration (HP:0011016)2.16142948
96Abnormality of purine metabolism (HP:0004352)2.15372787
97Hyperglycinuria (HP:0003108)2.13565145
98Abnormal urine phosphate concentration (HP:0012599)2.12552710
99Growth hormone excess (HP:0000845)2.12477663
100Skin nodule (HP:0200036)2.12292053
101Nephrolithiasis (HP:0000787)2.11879317
102Hypophosphatemic rickets (HP:0004912)2.11280686
103Atrophic scars (HP:0001075)2.08828001
104Ventricular tachycardia (HP:0004756)2.08408120
105Abnormality of nucleobase metabolism (HP:0010932)2.07999638
106Goiter (HP:0000853)2.07736764
107Wide cranial sutures (HP:0010537)2.07034096
108Congenital sensorineural hearing impairment (HP:0008527)2.06274980
109Cheilitis (HP:0100825)2.03315074
110Joint hemorrhage (HP:0005261)2.01924405
111Abnormal hair laboratory examination (HP:0003328)2.01220735
112Abnormality of the gastric mucosa (HP:0004295)2.00849390
113Breech presentation (HP:0001623)2.00806545
114Flat capital femoral epiphysis (HP:0003370)1.99707377
115Plantar hyperkeratosis (HP:0007556)1.99624294
116Abnormality of vitamin metabolism (HP:0100508)1.99262294
117Increased mean platelet volume (HP:0011877)1.97862281
118Abnormality of renin-angiotensin system (HP:0000847)1.97317378
119Renal tubular acidosis (HP:0001947)1.96499343
120Subcapsular cataract (HP:0000523)1.95027644
121Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.94763340
122Hyperphosphaturia (HP:0003109)1.94281048
123Delayed epiphyseal ossification (HP:0002663)1.94118281
124Metabolic acidosis (HP:0001942)1.93849917
125Increased IgE level (HP:0003212)1.91840258
126Abnormal hand bone ossification (HP:0010660)1.91076244
127Hyperparathyroidism (HP:0000843)1.90988389
128Abnormal glucose tolerance (HP:0001952)1.90910154
129Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90787924
130Irregular epiphyses (HP:0010582)1.90493028
131Rickets (HP:0002748)1.90412859
132Enlarged epiphyses (HP:0010580)1.90059956
133Abnormal cartilage morphology (HP:0002763)1.89548333
134Vertebral clefting (HP:0008428)1.89522484
135Hyponatremia (HP:0002902)1.89256430
136Protuberant abdomen (HP:0001538)1.88644726
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88439709
138Ureteral stenosis (HP:0000071)1.87714377
139Polygenic inheritance (HP:0010982)1.87340736
140Mesangial abnormality (HP:0001966)1.87239424
141Abnormal ossification of hand bones (HP:0005921)1.86780218
142Thin bony cortex (HP:0002753)1.84920060
143Polycythemia (HP:0001901)1.84803861
144Spinal cord compression (HP:0002176)1.84391656
145Metaphyseal irregularity (HP:0003025)1.83896023
146Rectal prolapse (HP:0002035)1.83259791
147Posterior subcapsular cataract (HP:0007787)1.82536422
148Cardiovascular calcification (HP:0011915)1.81891672
149Combined immunodeficiency (HP:0005387)1.81178436
150Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80884417
151Dicarboxylic aciduria (HP:0003215)1.80884417
152Pancreatitis (HP:0001733)1.78268577
153Hypokalemia (HP:0002900)1.78057407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.09468226
2PIK3CA5.38780704
3ACVR1B4.69853726
4FRK4.64266218
5TAOK33.98395214
6MST43.76796938
7MAP3K23.60884884
8RIPK13.24162291
9LMTK23.17785327
10KSR23.15247748
11NME13.11156963
12MAP2K22.99947235
13STK392.62182296
14EPHB22.58414345
15PRKG22.50884188
16MET2.44017832
17GRK62.40430361
18WNK42.33756938
19FGFR31.89371975
20EPHA31.78140166
21TAOK11.71929231
22EPHA21.69331219
23AKT31.55708466
24TESK11.42789935
25MAP2K11.38373913
26PTK61.32649947
27MYLK1.30243055
28IRAK31.27144569
29OXSR11.25721301
30MAP3K101.23742242
31RIPK41.23522015
32MAP3K11.13104743
33PTK20.98783842
34MAP3K80.98607608
35PRKCI0.96388709
36TESK20.96063709
37EPHA40.92375609
38NUAK10.91565967
39TRIB30.90144204
40SIK10.89577455
41CAMK2D0.88496274
42MAP3K90.86937977
43STK100.85819194
44MAP3K120.85203655
45TNIK0.83272635
46STK240.82786320
47ERN10.79997979
48EPHB10.77747646
49DDR20.76856593
50PKN20.75931182
51TYK20.74426575
52PDGFRA0.71957313
53PRPF4B0.70572448
54MATK0.67457482
55FER0.66574121
56ERBB20.65099506
57TBK10.63933354
58TTK0.62349048
59CASK0.61753142
60DMPK0.61073239
61MAP3K110.55877884
62BCR0.54952968
63PRKAA20.50917519
64MAP3K140.50160624
65MAP3K70.48626906
66INSRR0.47561037
67LIMK10.47494829
68ICK0.47003398
69MAP2K60.45920776
70PRKCZ0.44504179
71RET0.43782660
72BMX0.42744727
73YES10.40627725
74PDPK10.38090467
75MAPK110.37062805
76MELK0.35354036
77CDK90.35037919
78ARAF0.34121590
79MAPKAPK30.33771249
80SRC0.32747167
81PAK40.32048177
82IRAK10.31879219
83FGFR10.31534718
84ERBB40.31452589
85PAK30.30819900
86STK110.29509001
87AURKB0.28757062
88MAP3K30.27799291
89NEK60.26946698
90EEF2K0.26496165
91PRKCA0.26429338
92MAP3K50.24850016
93EIF2AK10.24419140
94PBK0.23663989
95ITK0.22996915
96NTRK30.22954392
97PRKAA10.20612681
98CAMK2B0.20039781
99PDK10.19942076
100NTRK10.19691267
101PAK10.19173108
102MAP3K60.18844154
103CAMK2G0.18395952
104CSK0.17571296
105SGK10.16725851
106MAPK30.16534702
107IGF1R0.16132550
108MAPKAPK20.16064380
109FYN0.15032823
110ROCK10.13547325
111NLK0.13387850
112PAK20.12628105
113LATS10.12405732
114PRKACG0.12377032
115PDK20.12202709
116DYRK1B0.12045191
117CSNK1E0.11815328
118IKBKE0.10811903
119PRKCD0.10060757
120CSNK1A10.09687188
121FGFR40.09649997
122RPS6KA10.09548026
123TYRO30.08511388
124CDC42BPA0.08214733
125PRKCQ0.07981512
126CDK150.07976187
127PTK2B0.07916018
128GRK10.07378962
129CDK180.07130568
130JAK20.06706077
131CDK11A0.06546082
132KSR10.06304912
133CDK50.06158650
134AKT20.04478192
135WNK10.03268541

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.06558790
2Mineral absorption_Homo sapiens_hsa049784.93001996
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.72419931
4Renin-angiotensin system_Homo sapiens_hsa046144.08325896
5Sulfur metabolism_Homo sapiens_hsa009203.65035036
6Vitamin digestion and absorption_Homo sapiens_hsa049773.14028280
7Bile secretion_Homo sapiens_hsa049762.88575793
8Galactose metabolism_Homo sapiens_hsa000522.70735501
9Caffeine metabolism_Homo sapiens_hsa002322.69435115
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.39976364
11Starch and sucrose metabolism_Homo sapiens_hsa005002.15022361
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13393428
13Protein digestion and absorption_Homo sapiens_hsa049742.04877864
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77032603
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.75402596
16Folate biosynthesis_Homo sapiens_hsa007901.75124403
17Fructose and mannose metabolism_Homo sapiens_hsa000511.71785409
18Histidine metabolism_Homo sapiens_hsa003401.66702593
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66687108
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60906557
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41299177
22Complement and coagulation cascades_Homo sapiens_hsa046101.36018621
23Glycerolipid metabolism_Homo sapiens_hsa005611.30751695
24PPAR signaling pathway_Homo sapiens_hsa033201.25292512
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20865297
26Sphingolipid metabolism_Homo sapiens_hsa006001.17178302
27Tryptophan metabolism_Homo sapiens_hsa003801.15384262
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10083012
29Glutathione metabolism_Homo sapiens_hsa004801.09980110
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08280394
31Fatty acid metabolism_Homo sapiens_hsa012121.01053202
32Tight junction_Homo sapiens_hsa045301.00799996
33Fatty acid biosynthesis_Homo sapiens_hsa000610.95123559
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94123212
35Other glycan degradation_Homo sapiens_hsa005110.92433602
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89489198
37Salivary secretion_Homo sapiens_hsa049700.88572833
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86277922
39Thyroid hormone synthesis_Homo sapiens_hsa049180.85503327
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84295391
41Pancreatic secretion_Homo sapiens_hsa049720.81838099
42ABC transporters_Homo sapiens_hsa020100.76730120
43Tyrosine metabolism_Homo sapiens_hsa003500.76434564
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76302646
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.75544352
46Type II diabetes mellitus_Homo sapiens_hsa049300.73251295
47Arginine biosynthesis_Homo sapiens_hsa002200.72805835
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71232846
49Salmonella infection_Homo sapiens_hsa051320.70341003
50Thyroid cancer_Homo sapiens_hsa052160.68203839
51Peroxisome_Homo sapiens_hsa041460.67551252
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.66112404
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65905236
54Biosynthesis of amino acids_Homo sapiens_hsa012300.65287273
55Fatty acid degradation_Homo sapiens_hsa000710.62999060
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61583345
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61220419
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59654534
59Gastric acid secretion_Homo sapiens_hsa049710.58965522
60Hepatitis C_Homo sapiens_hsa051600.58913679
61African trypanosomiasis_Homo sapiens_hsa051430.56985456
62Arginine and proline metabolism_Homo sapiens_hsa003300.55311972
63Staphylococcus aureus infection_Homo sapiens_hsa051500.54304385
64Chemical carcinogenesis_Homo sapiens_hsa052040.54175075
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.53979483
66Sulfur relay system_Homo sapiens_hsa041220.53175735
67Bladder cancer_Homo sapiens_hsa052190.51598845
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.49700371
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.49239404
70Adherens junction_Homo sapiens_hsa045200.48816729
71Pentose phosphate pathway_Homo sapiens_hsa000300.48078060
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.46561613
73Insulin resistance_Homo sapiens_hsa049310.45279128
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41226758
75Linoleic acid metabolism_Homo sapiens_hsa005910.39482223
76Ovarian steroidogenesis_Homo sapiens_hsa049130.39414885
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38022874
78GnRH signaling pathway_Homo sapiens_hsa049120.37357700
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.37084549
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.36844712
81Choline metabolism in cancer_Homo sapiens_hsa052310.36736826
82Propanoate metabolism_Homo sapiens_hsa006400.36656817
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36162603
84Pyruvate metabolism_Homo sapiens_hsa006200.34944103
85Butanoate metabolism_Homo sapiens_hsa006500.33053376
86Nitrogen metabolism_Homo sapiens_hsa009100.32361949
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30779189
88beta-Alanine metabolism_Homo sapiens_hsa004100.30763929
89Retinol metabolism_Homo sapiens_hsa008300.30719251
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30439974
91Carbon metabolism_Homo sapiens_hsa012000.29446179
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29043994
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28037896
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27606610
95Dorso-ventral axis formation_Homo sapiens_hsa043200.26947737
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26611500
97N-Glycan biosynthesis_Homo sapiens_hsa005100.26088892
98Gap junction_Homo sapiens_hsa045400.25871106
99Glucagon signaling pathway_Homo sapiens_hsa049220.25785625
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24129781
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23519724
102Fatty acid elongation_Homo sapiens_hsa000620.21176726
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20948761
104Renin secretion_Homo sapiens_hsa049240.20573775
105Arachidonic acid metabolism_Homo sapiens_hsa005900.19802883
106Pertussis_Homo sapiens_hsa051330.19354412
107Insulin secretion_Homo sapiens_hsa049110.19198491
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19180434
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.19071873
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18696424
111Metabolic pathways_Homo sapiens_hsa011000.17123190
112VEGF signaling pathway_Homo sapiens_hsa043700.15577629
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.15571226
114AMPK signaling pathway_Homo sapiens_hsa041520.15228797
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.14890980
116Alzheimers disease_Homo sapiens_hsa050100.14690997
117Long-term depression_Homo sapiens_hsa047300.14625983
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13428342
119Ether lipid metabolism_Homo sapiens_hsa005650.11051360
120Vibrio cholerae infection_Homo sapiens_hsa051100.10920902
121Influenza A_Homo sapiens_hsa051640.09662886
122TNF signaling pathway_Homo sapiens_hsa046680.09661838
123Steroid biosynthesis_Homo sapiens_hsa001000.09217653
124Phenylalanine metabolism_Homo sapiens_hsa003600.09214003
125Toxoplasmosis_Homo sapiens_hsa051450.09064392
126HIF-1 signaling pathway_Homo sapiens_hsa040660.08882804
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.08758022
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08436379
129Hematopoietic cell lineage_Homo sapiens_hsa046400.08121002
130Vitamin B6 metabolism_Homo sapiens_hsa007500.06828392
131Cocaine addiction_Homo sapiens_hsa050300.05857677
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05721449
133Prion diseases_Homo sapiens_hsa050200.04886267
134Asthma_Homo sapiens_hsa053100.03978828

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