PTPRJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.16618211
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.16618211
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.16618211
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.16618211
5modulation by symbiont of host immune response (GO:0052553)6.16618211
6positive regulation by symbiont of host defense response (GO:0052509)6.16618211
7regulation of interferon-beta biosynthetic process (GO:0045357)5.03655199
8macrophage activation involved in immune response (GO:0002281)4.92044792
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.44695503
10detection of other organism (GO:0098543)4.27901004
11response to host immune response (GO:0052572)4.18373269
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.18373269
13positive regulation of interferon-alpha production (GO:0032727)4.15457320
14detection of external biotic stimulus (GO:0098581)4.01660124
15regulation of interferon-alpha production (GO:0032647)3.97563454
16microglial cell activation (GO:0001774)3.93818811
17response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.92605301
18response to host (GO:0075136)3.92605301
19response to host defenses (GO:0052200)3.92605301
20detection of bacterium (GO:0016045)3.86611704
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.73380052
22regulation of gamma-delta T cell differentiation (GO:0045586)3.66963622
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62889185
24I-kappaB phosphorylation (GO:0007252)3.59531244
25leukocyte aggregation (GO:0070486)3.58941089
26detection of biotic stimulus (GO:0009595)3.54532377
27response to peptidoglycan (GO:0032494)3.54042764
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.42231586
29positive regulation of gamma-delta T cell activation (GO:0046645)3.38341520
30macrophage activation (GO:0042116)3.29816355
31regulation of B cell receptor signaling pathway (GO:0050855)3.27848017
32negative regulation of T cell mediated immunity (GO:0002710)3.21123934
33production of molecular mediator involved in inflammatory response (GO:0002532)3.19505370
34positive regulation of cellular amide metabolic process (GO:0034250)3.18699013
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15139191
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14810435
37neutrophil mediated immunity (GO:0002446)3.14774830
38neutrophil activation involved in immune response (GO:0002283)3.14043163
39negative regulation of leukocyte mediated immunity (GO:0002704)3.10349547
40antigen processing and presentation of endogenous antigen (GO:0019883)3.06844332
41positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.06635391
42regulation of mast cell activation involved in immune response (GO:0033006)3.05664175
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02654837
44regulation of cholesterol storage (GO:0010885)2.98023178
45regulation of mast cell activation (GO:0033003)2.97758552
46response to interleukin-15 (GO:0070672)2.97588922
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.96842349
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96487594
49immunoglobulin mediated immune response (GO:0016064)2.96153730
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95288122
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95288122
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94120516
53antigen processing and presentation via MHC class Ib (GO:0002475)2.92686628
54regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92561637
55leukocyte migration involved in inflammatory response (GO:0002523)2.91922829
56T-helper 1 type immune response (GO:0042088)2.91257544
57positive thymic T cell selection (GO:0045059)2.90272172
58myeloid cell activation involved in immune response (GO:0002275)2.89970556
59defense response to protozoan (GO:0042832)2.87804631
60regulation of T-helper 2 cell differentiation (GO:0045628)2.87751572
61negative regulation of cell killing (GO:0031342)2.86386742
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86386742
63negative regulation of erythrocyte differentiation (GO:0045647)2.85572943
64regulation of T cell tolerance induction (GO:0002664)2.84862620
65regulation of tolerance induction (GO:0002643)2.83744499
66myeloid leukocyte mediated immunity (GO:0002444)2.81466302
67positive regulation of interferon-beta production (GO:0032728)2.81004378
68negative thymic T cell selection (GO:0045060)2.76627106
69myeloid leukocyte activation (GO:0002274)2.75564676
70respiratory burst (GO:0045730)2.75472005
71apoptotic cell clearance (GO:0043277)2.75093153
72positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74778161
73low-density lipoprotein particle clearance (GO:0034383)2.74012201
74negative T cell selection (GO:0043383)2.71052245
75response to muramyl dipeptide (GO:0032495)2.67993732
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67832939
77T cell migration (GO:0072678)2.67309178
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.66712247
79regulation of B cell differentiation (GO:0045577)2.66642781
80regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.65919230
81dendritic cell migration (GO:0036336)2.64731521
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64133315
83response to protozoan (GO:0001562)2.62495341
84granulocyte activation (GO:0036230)2.62027483
85positive T cell selection (GO:0043368)2.61605839
86negative regulation of interleukin-12 production (GO:0032695)2.61522611
87B cell receptor signaling pathway (GO:0050853)2.61509145
88dendritic cell chemotaxis (GO:0002407)2.61407206
89positive regulation of antigen processing and presentation (GO:0002579)2.61041549
90positive regulation of chemokine biosynthetic process (GO:0045080)2.60623564
91detection of molecule of bacterial origin (GO:0032490)2.59734737
92positive regulation of B cell differentiation (GO:0045579)2.56277666
93mannose metabolic process (GO:0006013)2.54877563
94interferon-gamma-mediated signaling pathway (GO:0060333)2.52866736
95germinal center formation (GO:0002467)2.52745507
96positive regulation of macrophage cytokine production (GO:0060907)2.51776765
97regulation of interleukin-8 biosynthetic process (GO:0045414)2.50185948
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49805924
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49785228
100negative regulation of toll-like receptor signaling pathway (GO:0034122)2.49383278
101complement activation, alternative pathway (GO:0006957)2.47845461
102neutrophil activation (GO:0042119)2.46872647
103regulation of membrane protein ectodomain proteolysis (GO:0051043)2.43980387
104cellular extravasation (GO:0045123)2.43180085
105lipoprotein transport (GO:0042953)2.40234522
106cell adhesion mediated by integrin (GO:0033627)2.39658754
107plasma lipoprotein particle clearance (GO:0034381)2.39111141
108regulation of gamma-delta T cell activation (GO:0046643)2.38625270
109positive regulation of phagocytosis (GO:0050766)2.38467948
110regulation of interferon-gamma biosynthetic process (GO:0045072)2.37463644
111positive regulation of mast cell activation involved in immune response (GO:0033008)2.36960661
112positive regulation of mast cell degranulation (GO:0043306)2.36960661
113positive regulation of leukocyte degranulation (GO:0043302)2.35363310
114hydrogen peroxide biosynthetic process (GO:0050665)2.33667219
115regulation of leukocyte degranulation (GO:0043300)2.33394575
116modification by symbiont of host morphology or physiology (GO:0044003)2.33255666
117response to type I interferon (GO:0034340)2.33098455
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.32945216
119negative regulation of interleukin-17 production (GO:0032700)2.32240154
120regulation of mast cell degranulation (GO:0043304)2.31810759
121positive regulation of mast cell activation (GO:0033005)2.31548518
122regulation of phagocytosis (GO:0050764)2.31026874
123type I interferon signaling pathway (GO:0060337)2.30079290
124cellular response to type I interferon (GO:0071357)2.30079290
125positive regulation of heat generation (GO:0031652)2.28894529
126regulation of podosome assembly (GO:0071801)2.28024776
127regulation of toll-like receptor signaling pathway (GO:0034121)2.26551789
128phospholipid homeostasis (GO:0055091)2.26089019
129mature B cell differentiation (GO:0002335)2.25997799
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.24570065
131regulation of mononuclear cell migration (GO:0071675)2.23163191
132regulation of macrophage cytokine production (GO:0010935)2.22306153
133cytokine secretion (GO:0050663)2.21405586
134cellular response to ethanol (GO:0071361)2.20706086
135positive regulation of p38MAPK cascade (GO:1900745)2.20014573
136regulation of ARF protein signal transduction (GO:0032012)2.18469263
137negative regulation of lipid storage (GO:0010888)2.17723088
138regulation of cellular amide metabolic process (GO:0034248)2.17472413
139neutrophil chemotaxis (GO:0030593)2.16441506
140positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.16288809
141regulation of alkaline phosphatase activity (GO:0010692)2.15857802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.63619145
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.14499283
3* IRF8_27001747_Chip-Seq_BMDM_Mouse3.42198226
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11212373
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.95181391
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76813813
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74652792
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69641295
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68801292
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66857168
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.62796936
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52213454
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33891740
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.28049082
15* RXR_22158963_ChIP-Seq_LIVER_Mouse2.20349052
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.18351186
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08205631
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01362764
19GATA1_22025678_ChIP-Seq_K562_Human1.99865258
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97406339
21* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96361816
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95039012
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93828681
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91245635
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84794262
26RUNX_20019798_ChIP-Seq_JUKART_Human1.74417683
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70173839
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64956665
29* SPI1_23127762_ChIP-Seq_K562_Human1.64010884
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62256245
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59332998
32* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59170238
33* VDR_24787735_ChIP-Seq_THP-1_Human1.52914008
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45070828
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44852421
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.43941278
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42827514
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42540213
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.42487654
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40149552
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38153157
42* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31628391
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29909611
44TCF7_22412390_ChIP-Seq_EML_Mouse1.28340546
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28203727
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26603388
47GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25624231
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25602281
49VDR_24763502_ChIP-Seq_THP-1_Human1.25458559
50PU_27001747_Chip-Seq_BMDM_Mouse1.25347364
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23429187
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.22398066
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.20107889
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18363416
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17286547
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16868848
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16383936
58MAF_26560356_Chip-Seq_TH2_Human1.16379489
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16263115
60* SCL_19346495_ChIP-Seq_HPC-7_Human1.15541161
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.15401772
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15119443
63* KDM2B_26808549_Chip-Seq_DND41_Human1.12971924
64MAF_26560356_Chip-Seq_TH1_Human1.10497587
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08830598
66* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08795399
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08033758
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06966269
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05991616
70* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05658627
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04629494
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04329647
73* GATA2_19941826_ChIP-Seq_K562_Human1.04181003
74TP53_16413492_ChIP-PET_HCT116_Human1.03486046
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01428063
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.00662527
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00398097
78* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00332325
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.00152740
80VDR_21846776_ChIP-Seq_THP-1_Human1.00107896
81* GATA1_19941826_ChIP-Seq_K562_Human0.99649048
82* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99133952
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98829246
84MYB_26560356_Chip-Seq_TH2_Human0.97402215
85DROSHA_22980978_ChIP-Seq_HELA_Human0.96817504
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96229264
87RUNX1_22412390_ChIP-Seq_EML_Mouse0.94731870
88* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93953286
89MYB_26560356_Chip-Seq_TH1_Human0.93083464
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92902810
91LXR_22292898_ChIP-Seq_THP-1_Human0.92135946
92GATA3_27048872_Chip-Seq_THYMUS_Human0.91722467
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91567492
94RXR_22108803_ChIP-Seq_LS180_Human0.91398804
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91326704
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90496583
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.90313992
98* KDM2B_26808549_Chip-Seq_K562_Human0.89676650
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89564705
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89564705
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88099826
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84916894
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84224371
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82491267
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82318643
106MYC_22102868_ChIP-Seq_BL_Human0.81813674
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.81790167
108* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81458292
109* AHR_22903824_ChIP-Seq_MCF-7_Human0.81427903
110* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81424806
111EGR1_19032775_ChIP-ChIP_M12_Human0.80541651
112NCOR1_26117541_ChIP-Seq_K562_Human0.79512813
113UTX_26944678_Chip-Seq_JUKART_Human0.78073537
114* ELK3_25401928_ChIP-Seq_HUVEC_Human0.78061339
115* KDM2B_26808549_Chip-Seq_JURKAT_Human0.76374323
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76192481
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76178961
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76116394
119* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75692873
120SPI1_23547873_ChIP-Seq_NB4_Human0.75570225
121TFEB_21752829_ChIP-Seq_HELA_Human0.75121494
122GATA3_26560356_Chip-Seq_TH2_Human0.73312159
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73174369
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70946298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.00884097
2MP0001835_abnormal_antigen_presentation3.23329236
3MP0005058_abnormal_lysosome_morphology2.93940827
4MP0003436_decreased_susceptibility_to2.88543213
5MP0000569_abnormal_digit_pigmentation2.72327374
6MP0003300_gastrointestinal_ulcer2.68784768
7MP0003172_abnormal_lysosome_physiology2.59031899
8MP0005387_immune_system_phenotype2.57910444
9MP0001790_abnormal_immune_system2.57910444
10MP0002419_abnormal_innate_immunity2.46087594
11MP0006082_CNS_inflammation2.41121519
12MP0009840_abnormal_foam_cell2.38227559
13MP0008260_abnormal_autophagy2.33524211
14MP0003191_abnormal_cellular_cholesterol2.31617405
15MP0004510_myositis2.31360537
16MP0005000_abnormal_immune_tolerance2.30395264
17MP0002139_abnormal_hepatobiliary_system2.23145337
18MP0005451_abnormal_body_composition2.22773387
19MP0005360_urolithiasis2.19800101
20MP0001800_abnormal_humoral_immune2.19596984
21MP0000604_amyloidosis2.16879951
22MP0009785_altered_susceptibility_to2.16028135
23MP0003075_altered_response_to2.14306922
24MP0002452_abnormal_antigen_presenting2.11307612
25MP0000685_abnormal_immune_system2.07957387
26MP0005025_abnormal_response_to2.02050978
27MP0003763_abnormal_thymus_physiology1.98752575
28MP0005464_abnormal_platelet_physiology1.97820588
29MP0002723_abnormal_immune_serum1.88560666
30MP0002148_abnormal_hypersensitivity_rea1.85166169
31MP0003690_abnormal_glial_cell1.84028541
32MP0005365_abnormal_bile_salt1.81197034
33MP0004947_skin_inflammation1.81167779
34MP0005083_abnormal_biliary_tract1.79942511
35MP0003252_abnormal_bile_duct1.79650157
36MP0003183_abnormal_peptide_metabolism1.72266830
37MP0005085_abnormal_gallbladder_physiolo1.70894709
38MP0003828_pulmonary_edema1.65706766
39MP0001533_abnormal_skeleton_physiology1.63923226
40MP0004859_abnormal_synaptic_plasticity1.63859251
41MP0004883_abnormal_blood_vessel1.63741910
42MP0002254_reproductive_system_inflammat1.63527913
43MP0009764_decreased_sensitivity_to1.63365376
44MP0001819_abnormal_immune_cell1.62287589
45MP0000858_altered_metastatic_potential1.61423381
46MP0002420_abnormal_adaptive_immunity1.60351359
47MP0001845_abnormal_inflammatory_respons1.56363027
48MP0003724_increased_susceptibility_to1.55984674
49MP0005166_decreased_susceptibility_to1.55103509
50MP0002138_abnormal_hepatobiliary_system1.54551772
51MP0003045_fibrosis1.52549667
52MP0005671_abnormal_response_to1.50365104
53MP0008469_abnormal_protein_level1.49979984
54MP0005310_abnormal_salivary_gland1.47751702
55MP0005167_abnormal_blood-brain_barrier1.45760278
56MP0010234_abnormal_vibrissa_follicle1.45618401
57MP0004858_abnormal_nervous_system1.42303776
58MP0000465_gastrointestinal_hemorrhage1.40733231
59MP0009278_abnormal_bone_marrow1.34342881
60MP0000015_abnormal_ear_pigmentation1.33670713
61MP0008875_abnormal_xenobiotic_pharmacok1.32609821
62MP0010329_abnormal_lipoprotein_level1.31789852
63MP0009333_abnormal_splenocyte_physiolog1.31639984
64MP0004381_abnormal_hair_follicle1.31638612
65MP0010155_abnormal_intestine_physiology1.29074432
66MP0003866_abnormal_defecation1.26715051
67MP0003705_abnormal_hypodermis_morpholog1.25888402
68MP0008004_abnormal_stomach_pH1.25560288
69MP0001853_heart_inflammation1.23868591
70MP0002166_altered_tumor_susceptibility1.18690764
71MP0000609_abnormal_liver_physiology1.18627228
72MP0001851_eye_inflammation1.17283840
73MP0002405_respiratory_system_inflammati1.16575255
74MP0002006_tumorigenesis1.15447388
75MP0002998_abnormal_bone_remodeling1.15185261
76* MP0000716_abnormal_immune_system1.14549883
77MP0000703_abnormal_thymus_morphology1.07490979
78MP0003448_altered_tumor_morphology1.04474713
79MP0001666_abnormal_nutrient_absorption1.04150543
80MP0003091_abnormal_cell_migration1.04053704
81MP0005076_abnormal_cell_differentiation1.03734693
82MP0003195_calcinosis1.02334099
83MP0000343_altered_response_to1.01560363
84MP0004808_abnormal_hematopoietic_stem1.00231256
85MP0008961_abnormal_basal_metabolism0.99186952
86* MP0002398_abnormal_bone_marrow0.98699669
87* MP0000689_abnormal_spleen_morphology0.98072616
88MP0003566_abnormal_cell_adhesion0.95845552
89MP0002396_abnormal_hematopoietic_system0.95294020
90MP0002877_abnormal_melanocyte_morpholog0.95001407
91MP0009763_increased_sensitivity_to0.94714402
92MP0010352_gastrointestinal_tract_polyps0.94177122
93MP0002928_abnormal_bile_duct0.90960092
94MP0002132_abnormal_respiratory_system0.90844602
95MP0005584_abnormal_enzyme/coenzyme_acti0.90834890
96MP0004130_abnormal_muscle_cell0.90664113
97MP0000371_diluted_coat_color0.88884142
98MP0002332_abnormal_exercise_endurance0.88735817
99MP0003453_abnormal_keratinocyte_physiol0.88190141
100MP0002118_abnormal_lipid_homeostasis0.87807208
101MP0001663_abnormal_digestive_system0.87717856
102MP0002136_abnormal_kidney_physiology0.86550454
103MP0003329_amyloid_beta_deposits0.86463686
104MP0001501_abnormal_sleep_pattern0.85435115
105* MP0002429_abnormal_blood_cell0.83546366
106MP0002909_abnormal_adrenal_gland0.82917346
107MP0001545_abnormal_hematopoietic_system0.82490697
108MP0005397_hematopoietic_system_phenotyp0.82490697
109MP0008874_decreased_physiological_sensi0.81540852
110MP0005319_abnormal_enzyme/_coenzyme0.81259005
111MP0005164_abnormal_response_to0.81196994
112MP0003656_abnormal_erythrocyte_physiolo0.80471132
113MP0010307_abnormal_tumor_latency0.80211219
114MP0005409_darkened_coat_color0.79052792
115MP0002168_other_aberrant_phenotype0.78063583
116MP0003633_abnormal_nervous_system0.77736046
117MP0002090_abnormal_vision0.77027521
118MP0005174_abnormal_tail_pigmentation0.75973511
119MP0000249_abnormal_blood_vessel0.75463318
120MP0002009_preneoplasia0.74532121
121MP0002722_abnormal_immune_system0.74169430
122MP0003221_abnormal_cardiomyocyte_apopto0.71768041
123MP0005332_abnormal_amino_acid0.71422805
124MP0005390_skeleton_phenotype0.70097576
125MP0001873_stomach_inflammation0.69761492
126MP0006054_spinal_hemorrhage0.68794170
127MP0005257_abnormal_intraocular_pressure0.68502088
128MP0005075_abnormal_melanosome_morpholog0.68030598
129MP0003795_abnormal_bone_structure0.67564259
130MP0000920_abnormal_myelination0.63360464
131MP0002277_abnormal_respiratory_mucosa0.62079134

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.92491290
2Recurrent gram-negative bacterial infections (HP:0005420)4.60031070
3Recurrent abscess formation (HP:0002722)4.50289894
4Recurrent bacterial skin infections (HP:0005406)4.40076697
5Eczematoid dermatitis (HP:0000976)4.27857884
6Increased cerebral lipofuscin (HP:0011813)3.91531452
7Glomerulonephritis (HP:0000099)3.82625519
8Complement deficiency (HP:0004431)3.81053482
9T lymphocytopenia (HP:0005403)3.63975655
10Gastrointestinal infarctions (HP:0005244)3.47683170
11Myocardial infarction (HP:0001658)3.45211148
12Dysostosis multiplex (HP:0000943)3.33741936
13Mediastinal lymphadenopathy (HP:0100721)3.33375486
14Abnormality of macrophages (HP:0004311)3.31429748
15Abnormality of T cell number (HP:0011839)3.30536684
16Abnormality of complement system (HP:0005339)3.25479761
17Prolonged bleeding time (HP:0003010)3.20587346
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.13874942
19Urinary glycosaminoglycan excretion (HP:0003541)3.10067264
20Mucopolysacchariduria (HP:0008155)3.10067264
21Autoimmune thrombocytopenia (HP:0001973)3.09632949
22Vacuolated lymphocytes (HP:0001922)3.09303110
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.08787724
24Keratoconjunctivitis sicca (HP:0001097)3.05771380
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.99260914
26Abnormality of polysaccharide metabolism (HP:0011012)2.99260914
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.99260914
28Epistaxis (HP:0000421)2.92735533
29Hematochezia (HP:0002573)2.91285561
30Colitis (HP:0002583)2.88530188
31Abnormality of glycolipid metabolism (HP:0010969)2.85664237
32Abnormality of liposaccharide metabolism (HP:0010968)2.85664237
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.85664237
34Nephritis (HP:0000123)2.85300604
35Gingivitis (HP:0000230)2.78429161
36Recurrent skin infections (HP:0001581)2.76829546
37Encephalitis (HP:0002383)2.76789587
38Keratoconjunctivitis (HP:0001096)2.75466924
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.73744903
40Chest pain (HP:0100749)2.73491624
41Deep venous thrombosis (HP:0002625)2.73142092
42Cellulitis (HP:0100658)2.71116206
43Mitral stenosis (HP:0001718)2.68186643
44Recurrent viral infections (HP:0004429)2.65392841
45Hemoptysis (HP:0002105)2.65025391
46Axonal loss (HP:0003447)2.63236111
47Periodontitis (HP:0000704)2.61972782
48Abnormal platelet volume (HP:0011876)2.61320565
49Joint hemorrhage (HP:0005261)2.59297451
50Vasculitis (HP:0002633)2.59149234
51Recurrent fungal infections (HP:0002841)2.58399260
52Petechiae (HP:0000967)2.57033229
53Purpura (HP:0000979)2.54765795
54Disinhibition (HP:0000734)2.54102455
55Orchitis (HP:0100796)2.50561335
56Peritonitis (HP:0002586)2.48113658
57Leukocytosis (HP:0001974)2.46263042
58Interstitial pulmonary disease (HP:0006530)2.44918899
59Loss of speech (HP:0002371)2.42072795
60Gingival bleeding (HP:0000225)2.39293321
61Myositis (HP:0100614)2.38715335
62Slow saccadic eye movements (HP:0000514)2.36288884
63Inflammation of the large intestine (HP:0002037)2.33402932
64Arterial thrombosis (HP:0004420)2.32133207
65Subacute progressive viral hepatitis (HP:0006572)2.30833279
66Esophageal varix (HP:0002040)2.30480006
67Xanthomatosis (HP:0000991)2.30205621
68Stomatitis (HP:0010280)2.29482700
69Pustule (HP:0200039)2.24905516
70Abnormality of the common coagulation pathway (HP:0010990)2.24177966
71Increased IgE level (HP:0003212)2.23937902
72Retrobulbar optic neuritis (HP:0100654)2.22636396
73Optic neuritis (HP:0100653)2.22636396
74Increased mean platelet volume (HP:0011877)2.20844734
75Gastrointestinal inflammation (HP:0004386)2.20672905
76Anorexia (HP:0002039)2.19912038
77Thick nail (HP:0001805)2.19856731
78Abnormality of T cells (HP:0002843)2.19754036
79Abnormality of the fingertips (HP:0001211)2.19750160
80Increased CSF protein (HP:0002922)2.15067202
81Amyloidosis (HP:0011034)2.14383725
82Chronic obstructive pulmonary disease (HP:0006510)2.12325598
83Obstructive lung disease (HP:0006536)2.12325598
84Pulmonary infiltrates (HP:0002113)2.12186919
85Osteomyelitis (HP:0002754)2.11394720
86Episodic fever (HP:0001954)2.10297357
87Cerebral aneurysm (HP:0004944)2.09730762
88Tetraparesis (HP:0002273)2.07593050
89Upper motor neuron abnormality (HP:0002127)2.07189463
90Viral hepatitis (HP:0006562)2.06727084
91Global brain atrophy (HP:0002283)2.05846248
92Agammaglobulinemia (HP:0004432)2.01673684
93Meningitis (HP:0001287)1.99640000
94Spontaneous hematomas (HP:0007420)1.98586501
95Gangrene (HP:0100758)1.98231044
96Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96966085
97Gastrointestinal stroma tumor (HP:0100723)1.94239088
98Menorrhagia (HP:0000132)1.94073976
99Abnormality of the peritoneum (HP:0002585)1.92888521
100Elevated erythrocyte sedimentation rate (HP:0003565)1.89751383
101Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89153530
102Chronic otitis media (HP:0000389)1.89070832
103Sepsis (HP:0100806)1.87043521
104Neuronal loss in central nervous system (HP:0002529)1.86334026
105Urticaria (HP:0001025)1.86216408
106Granulocytopenia (HP:0001913)1.86096318
107Peripheral demyelination (HP:0011096)1.85278706
108Mutism (HP:0002300)1.85121971
109Abnormality of the endocardium (HP:0004306)1.84915730
110Hypercholesterolemia (HP:0003124)1.84837668
111Arterial tortuosity (HP:0005116)1.84616461
112Recurrent bronchitis (HP:0002837)1.84256206
113Increased serum ferritin (HP:0003281)1.83173431
114Fatigue (HP:0012378)1.83168434
115Abnormality of the pleura (HP:0002103)1.82797533
116Epidermoid cyst (HP:0200040)1.82028900
117Recurrent cutaneous fungal infections (HP:0011370)1.81943075
118Chronic mucocutaneous candidiasis (HP:0002728)1.81943075
119Glomerulopathy (HP:0100820)1.81548962
120Vertigo (HP:0002321)1.81328441
121Papilledema (HP:0001085)1.81088999
122Malnutrition (HP:0004395)1.79256699
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79062781
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.78372225
125Osteolytic defects of the hand bones (HP:0009699)1.78372225
126Amaurosis fugax (HP:0100576)1.78272926
127Absent frontal sinuses (HP:0002688)1.78256973
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76991254
129Abnormality of the periventricular white matter (HP:0002518)1.76967316
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75629559
131Retinal atrophy (HP:0001105)1.74222429
132Eosinophilia (HP:0001880)1.73658858
133Prolonged partial thromboplastin time (HP:0003645)1.73212305
134Restrictive lung disease (HP:0002091)1.73032728
135Lymphopenia (HP:0001888)1.72860798
136Pulmonary embolism (HP:0002204)1.71656463
137Emphysema (HP:0002097)1.69863361
138Coarse hair (HP:0002208)1.69853021
139Thoracic kyphosis (HP:0002942)1.69359177
140Bone pain (HP:0002653)1.69024187
141Inappropriate behavior (HP:0000719)1.68688232
142Urethral obstruction (HP:0000796)1.67817699
143Spastic tetraparesis (HP:0001285)1.67505165
144Pathologic fracture (HP:0002756)1.66372265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.99400886
2ERN12.96855992
3TYK22.73154278
4MAP3K132.64427626
5MAP3K142.49149467
6PRPF4B2.37186302
7TBK12.33491690
8MAP4K12.30064301
9MAP3K32.26695663
10JAK12.25464199
11BLK2.10702074
12MAP3K92.09789953
13TGFBR22.03456912
14TAOK31.87191108
15DAPK21.80453512
16CAMK1D1.79773253
17IRAK31.79126363
18CSF1R1.75792660
19RIPK11.74712474
20TXK1.64022102
21FES1.63567091
22CSK1.62960399
23IKBKE1.61603952
24CAMK1G1.57264581
25IRAK41.50208299
26EPHB11.47280029
27TRIB31.45008127
28SIK21.42090432
29FGR1.39848913
30MAP3K111.35349096
31KSR21.35166227
32PTK61.34904989
33MAP3K101.30286927
34IKBKB1.29532596
35HCK1.27065085
36YES11.27032309
37JAK31.26461624
38JAK21.24273812
39MATK1.24186603
40KIT1.22043184
41CAMKK11.21794576
42STK241.21363867
43SCYL21.19731285
44TNK21.15526455
45SYK1.15298445
46FGFR31.13971246
47FRK1.12675371
48FGFR41.12636897
49MST1R1.12171591
50SIK11.11081304
51GRK61.10919296
52SGK31.06410163
53BMX1.06128518
54PKN21.03047343
55IRAK11.01962318
56TAOK20.99772349
57STK100.98914446
58MAP3K20.97444567
59IRAK20.96630704
60MARK20.94672250
61CDC42BPA0.91992283
62CHUK0.90788911
63PIK3CG0.90402654
64PDK10.89825636
65TEC0.85222532
66EPHA40.85156892
67SIK30.84591622
68MARK30.83870145
69LYN0.83169485
70ZAP700.82956370
71CDK120.82857444
72NTRK30.81628187
73EGFR0.81339632
74PRKCH0.79605084
75PDPK10.79448838
76WNK10.76700850
77RET0.73016083
78LCK0.72911662
79ALK0.68839314
80MAP3K10.68656561
81BTK0.68222108
82FYN0.68115729
83MAP3K60.67295058
84LRRK20.66233537
85TAOK10.66118025
86ACVR1B0.63416342
87BMPR20.62722513
88DAPK10.62546815
89CAMKK20.61049362
90MAP3K70.59612804
91SGK20.58909672
92TRPM70.54753035
93PAK60.54270166
94PDGFRB0.53727336
95CDK60.53574703
96RPS6KC10.53439358
97RPS6KL10.53439358
98PIM10.52292235
99MAPK120.52238993
100ABL10.52036651
101SGK10.51698414
102MAP3K50.51547835
103DMPK0.50891876
104MAP2K40.49402905
105PRKCQ0.49355207
106NTRK10.48516651
107TTN0.48415496
108ITK0.48323636
109HIPK20.48081959
110MAPK70.47713694
111NEK90.47237382
112EPHA30.46985745
113MELK0.46374890
114RPS6KA60.44290045
115PRKD20.42725600
116MAP2K30.41527289
117GSK3A0.40651373
118STK380.40643293
119INSR0.40598767
120GRK70.40538568
121PRKCD0.40097466
122STK110.39891264
123PTK2B0.39244970
124CAMK40.37592351
125IGF1R0.36391377
126MOS0.34533841
127STK30.33037970
128PRKAA20.32819908
129KSR10.32774396

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.26732124
2Nitrogen metabolism_Homo sapiens_hsa009102.48955914
3Leishmaniasis_Homo sapiens_hsa051402.29225298
4Osteoclast differentiation_Homo sapiens_hsa043802.04148252
5B cell receptor signaling pathway_Homo sapiens_hsa046622.04055410
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96981437
7Complement and coagulation cascades_Homo sapiens_hsa046101.83157784
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.72383460
9Tuberculosis_Homo sapiens_hsa051521.63799106
10Pertussis_Homo sapiens_hsa051331.60268125
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.58955839
12Autoimmune thyroid disease_Homo sapiens_hsa053201.58545350
13Lysosome_Homo sapiens_hsa041421.54320262
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.45938480
15Arginine biosynthesis_Homo sapiens_hsa002201.44803095
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44364943
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38213330
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32173122
19Primary immunodeficiency_Homo sapiens_hsa053401.28792830
20African trypanosomiasis_Homo sapiens_hsa051431.27921505
21TNF signaling pathway_Homo sapiens_hsa046681.26057923
22Malaria_Homo sapiens_hsa051441.25628409
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23665993
24Type II diabetes mellitus_Homo sapiens_hsa049301.21706011
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20851876
26Caffeine metabolism_Homo sapiens_hsa002321.17059986
27Viral myocarditis_Homo sapiens_hsa054161.14914515
28Toxoplasmosis_Homo sapiens_hsa051451.14462297
29Legionellosis_Homo sapiens_hsa051341.13631409
30Influenza A_Homo sapiens_hsa051641.13604600
31Chemokine signaling pathway_Homo sapiens_hsa040621.13418866
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12173530
33Renal cell carcinoma_Homo sapiens_hsa052111.08967949
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06357100
35Measles_Homo sapiens_hsa051621.05578001
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05149809
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04969844
38Other glycan degradation_Homo sapiens_hsa005110.99860998
39Prion diseases_Homo sapiens_hsa050200.96595891
40Graft-versus-host disease_Homo sapiens_hsa053320.94363772
41Salmonella infection_Homo sapiens_hsa051320.92386672
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90810001
43Hematopoietic cell lineage_Homo sapiens_hsa046400.88747852
44Phagosome_Homo sapiens_hsa041450.88522605
45Amoebiasis_Homo sapiens_hsa051460.86650520
46Rheumatoid arthritis_Homo sapiens_hsa053230.86138729
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.84149287
48Bile secretion_Homo sapiens_hsa049760.83318123
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82744619
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.80798668
51Hepatitis C_Homo sapiens_hsa051600.79735448
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79150767
53Endometrial cancer_Homo sapiens_hsa052130.79006659
54Dorso-ventral axis formation_Homo sapiens_hsa043200.76996576
55ABC transporters_Homo sapiens_hsa020100.75967115
56FoxO signaling pathway_Homo sapiens_hsa040680.75744325
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75072767
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74985235
59Insulin resistance_Homo sapiens_hsa049310.74480967
60Chronic myeloid leukemia_Homo sapiens_hsa052200.74408504
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73865948
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72818347
63Pancreatic cancer_Homo sapiens_hsa052120.72796982
64Shigellosis_Homo sapiens_hsa051310.72510791
65mTOR signaling pathway_Homo sapiens_hsa041500.71946490
66Hepatitis B_Homo sapiens_hsa051610.71065828
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.71043637
68Notch signaling pathway_Homo sapiens_hsa043300.70327180
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70216780
70Glioma_Homo sapiens_hsa052140.69952710
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69119464
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67759789
73Apoptosis_Homo sapiens_hsa042100.67249588
74Platelet activation_Homo sapiens_hsa046110.67230659
75T cell receptor signaling pathway_Homo sapiens_hsa046600.65900274
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65722018
77GnRH signaling pathway_Homo sapiens_hsa049120.64180963
78Prolactin signaling pathway_Homo sapiens_hsa049170.63565649
79HIF-1 signaling pathway_Homo sapiens_hsa040660.63497522
80Type I diabetes mellitus_Homo sapiens_hsa049400.62275277
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61858261
82Antigen processing and presentation_Homo sapiens_hsa046120.61854039
83Choline metabolism in cancer_Homo sapiens_hsa052310.60910385
84VEGF signaling pathway_Homo sapiens_hsa043700.60448674
85PPAR signaling pathway_Homo sapiens_hsa033200.59763900
86ErbB signaling pathway_Homo sapiens_hsa040120.59461914
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.59121737
88Non-small cell lung cancer_Homo sapiens_hsa052230.58038308
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.57489638
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57041219
91Allograft rejection_Homo sapiens_hsa053300.55686924
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55529548
93Acute myeloid leukemia_Homo sapiens_hsa052210.54946602
94Viral carcinogenesis_Homo sapiens_hsa052030.54617678
95Prostate cancer_Homo sapiens_hsa052150.53299875
96Long-term potentiation_Homo sapiens_hsa047200.52735044
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50626412
98Salivary secretion_Homo sapiens_hsa049700.49645415
99Bladder cancer_Homo sapiens_hsa052190.49010911
100Endocytosis_Homo sapiens_hsa041440.48030697
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47389348
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.47315659
103Rap1 signaling pathway_Homo sapiens_hsa040150.47202019
104HTLV-I infection_Homo sapiens_hsa051660.46177945
105Synaptic vesicle cycle_Homo sapiens_hsa047210.45980952
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45616039
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45455009
108Asthma_Homo sapiens_hsa053100.45399467
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.45303849
110Colorectal cancer_Homo sapiens_hsa052100.45146207
111Epstein-Barr virus infection_Homo sapiens_hsa051690.45096735
112Herpes simplex infection_Homo sapiens_hsa051680.44672818
113Proteoglycans in cancer_Homo sapiens_hsa052050.44511743
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44243205
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43875544
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43075048
117MAPK signaling pathway_Homo sapiens_hsa040100.41810641
118Inositol phosphate metabolism_Homo sapiens_hsa005620.41479977
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40955427
120Tryptophan metabolism_Homo sapiens_hsa003800.40644890
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39916226
122Olfactory transduction_Homo sapiens_hsa047400.39630019
123Estrogen signaling pathway_Homo sapiens_hsa049150.39307996
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39112329

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