PTPRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.10748811
2desmosome organization (GO:0002934)5.36553133
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.71292879
4L-phenylalanine catabolic process (GO:0006559)4.71292879
5L-phenylalanine metabolic process (GO:0006558)4.58109263
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.58109263
7cysteine metabolic process (GO:0006534)4.21186962
8negative regulation of fibrinolysis (GO:0051918)4.04482486
9aromatic amino acid family catabolic process (GO:0009074)4.00034567
10glyoxylate metabolic process (GO:0046487)3.97565930
11* cell-substrate junction assembly (GO:0007044)3.87940372
12sulfur amino acid catabolic process (GO:0000098)3.87663762
13homocysteine metabolic process (GO:0050667)3.77768500
14midgut development (GO:0007494)3.71442065
15lysine metabolic process (GO:0006553)3.70807870
16lysine catabolic process (GO:0006554)3.70807870
17kynurenine metabolic process (GO:0070189)3.58834227
18alpha-linolenic acid metabolic process (GO:0036109)3.58323146
19regulation of fibrinolysis (GO:0051917)3.57977810
20bile acid biosynthetic process (GO:0006699)3.54818979
21skin morphogenesis (GO:0043589)3.50737603
22indolalkylamine catabolic process (GO:0046218)3.39504365
23tryptophan catabolic process (GO:0006569)3.39504365
24indole-containing compound catabolic process (GO:0042436)3.39504365
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.34613960
26endodermal cell differentiation (GO:0035987)3.31949727
27urea cycle (GO:0000050)3.30852803
28urea metabolic process (GO:0019627)3.30852803
29regulation of protein activation cascade (GO:2000257)3.29084202
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.27906081
31serine family amino acid catabolic process (GO:0009071)3.26925971
32drug catabolic process (GO:0042737)3.21417751
33glutamate metabolic process (GO:0006536)3.20128374
34peptidyl-glutamic acid carboxylation (GO:0017187)3.20004962
35protein carboxylation (GO:0018214)3.20004962
36tryptophan metabolic process (GO:0006568)3.19017641
37cellular modified amino acid catabolic process (GO:0042219)3.18493549
38mesodermal cell differentiation (GO:0048333)3.17903304
39negative regulation of chondrocyte differentiation (GO:0032331)3.17386345
40regulation of transforming growth factor beta2 production (GO:0032909)3.15720958
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.13682437
42dicarboxylic acid biosynthetic process (GO:0043650)3.12284155
43regulation of complement activation (GO:0030449)3.09734075
44bile acid metabolic process (GO:0008206)3.08398882
45paraxial mesoderm development (GO:0048339)3.07811925
46epoxygenase P450 pathway (GO:0019373)3.05134021
47regulation of cholesterol homeostasis (GO:2000188)3.03044697
48COPI coating of Golgi vesicle (GO:0048205)3.02670922
49Golgi transport vesicle coating (GO:0048200)3.02670922
50cellular ketone body metabolic process (GO:0046950)3.01699622
51endocardial cushion development (GO:0003197)2.99440021
52high-density lipoprotein particle remodeling (GO:0034375)2.98740816
53aspartate family amino acid catabolic process (GO:0009068)2.95648171
54hippo signaling (GO:0035329)2.94248835
55cellular glucuronidation (GO:0052695)2.94234412
56regulation of bile acid biosynthetic process (GO:0070857)2.93979440
57negative regulation of sterol transport (GO:0032372)2.93631758
58negative regulation of cholesterol transport (GO:0032375)2.93631758
59complement activation, alternative pathway (GO:0006957)2.92766458
60nitrogen cycle metabolic process (GO:0071941)2.92159355
61epithelial cell-cell adhesion (GO:0090136)2.92078897
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91041087
63exogenous drug catabolic process (GO:0042738)2.90147187
64alpha-amino acid catabolic process (GO:1901606)2.89791264
65regulation of hippo signaling (GO:0035330)2.89496487
66lung epithelium development (GO:0060428)2.88105017
67retina vasculature morphogenesis in camera-type eye (GO:0061299)2.88060917
68positive regulation of fatty acid beta-oxidation (GO:0032000)2.86347070
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85510932
70phosphate ion transmembrane transport (GO:0035435)2.85352251
71serine family amino acid metabolic process (GO:0009069)2.85178062
72protein retention in ER lumen (GO:0006621)2.84761758
73pyrimidine nucleobase catabolic process (GO:0006208)2.82967677
74substrate-dependent cell migration (GO:0006929)2.77797324
75cellular amino acid catabolic process (GO:0009063)2.77401837
76gap junction assembly (GO:0016264)2.77148798
77triglyceride homeostasis (GO:0070328)2.75763405
78acylglycerol homeostasis (GO:0055090)2.75763405
79notochord development (GO:0030903)2.74902154
80regulation of cardioblast differentiation (GO:0051890)2.74284927
81aromatic amino acid family metabolic process (GO:0009072)2.73922707
82amino-acid betaine metabolic process (GO:0006577)2.73667140
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73114320
84* negative regulation of keratinocyte proliferation (GO:0010839)2.72961628
85cell migration involved in sprouting angiogenesis (GO:0002042)2.72851886
86ethanol oxidation (GO:0006069)2.72040435
87drug transmembrane transport (GO:0006855)2.71921481
88regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71863282
89negative regulation of fatty acid transport (GO:2000192)2.71830727
90reverse cholesterol transport (GO:0043691)2.71102686
91phosphate ion transport (GO:0006817)2.67873310
92establishment of tissue polarity (GO:0007164)2.67043807
93establishment of planar polarity (GO:0001736)2.67043807
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66846355
95basement membrane organization (GO:0071711)2.66468589
96serine family amino acid biosynthetic process (GO:0009070)2.66016954
97regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65088177
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.64749775
99axon extension involved in axon guidance (GO:0048846)2.64749775
100acetyl-CoA metabolic process (GO:0006084)2.62035897
101fibrinolysis (GO:0042730)2.61897246
102endothelial cell morphogenesis (GO:0001886)2.61661533
103renal filtration (GO:0097205)2.60871745
104keratinocyte proliferation (GO:0043616)2.60772844
105coenzyme catabolic process (GO:0009109)2.60503919
106embryonic foregut morphogenesis (GO:0048617)2.60028020
107semaphorin-plexin signaling pathway (GO:0071526)2.59939517
108COPII vesicle coating (GO:0048208)2.58962775
109regulation of plasminogen activation (GO:0010755)2.58299190
110urate metabolic process (GO:0046415)2.58120023
111polarized epithelial cell differentiation (GO:0030859)2.56974645
112regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.56122346
113tyrosine metabolic process (GO:0006570)2.56108199
114ketone body metabolic process (GO:1902224)2.55966808
115glycine metabolic process (GO:0006544)2.55865675
116cell adhesion mediated by integrin (GO:0033627)2.55339292
117regulation of triglyceride catabolic process (GO:0010896)2.54424773
118response to nitrosative stress (GO:0051409)2.53911643
119hypotonic response (GO:0006971)2.53655129
120negative regulation of axon extension involved in axon guidance (GO:0048843)2.53405656
121G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.53226648
122bile acid and bile salt transport (GO:0015721)2.52571241
123short-chain fatty acid metabolic process (GO:0046459)2.51766425
124branching involved in mammary gland duct morphogenesis (GO:0060444)2.51418769
125uronic acid metabolic process (GO:0006063)2.50896808
126glucuronate metabolic process (GO:0019585)2.50896808
127regulation of axon extension involved in axon guidance (GO:0048841)2.50778439
128* adherens junction assembly (GO:0034333)2.50201434
129nucleobase catabolic process (GO:0046113)2.50190118
130protein localization to endosome (GO:0036010)2.50121199
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50077139
132collagen fibril organization (GO:0030199)2.49123253
133anterior/posterior axis specification, embryo (GO:0008595)2.47562817
134negative regulation of lipase activity (GO:0060192)2.47007079
135* cell junction assembly (GO:0034329)2.46132907
136plasma lipoprotein particle clearance (GO:0034381)2.45909102
137regulation of fatty acid beta-oxidation (GO:0031998)2.44459222
138Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.42798681
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.41754848
140response to mercury ion (GO:0046689)2.41475940
141positive regulation of osteoblast proliferation (GO:0033690)2.41118653
142sterol homeostasis (GO:0055092)2.41057817
143flavonoid metabolic process (GO:0009812)2.40965177
144negative regulation of protein activation cascade (GO:2000258)2.40914757
145chondrocyte proliferation (GO:0035988)2.40254693
146intestinal cholesterol absorption (GO:0030299)2.40241243
147phospholipid homeostasis (GO:0055091)2.39933635
148surfactant homeostasis (GO:0043129)2.38450491
149cholesterol homeostasis (GO:0042632)2.38221070
150benzene-containing compound metabolic process (GO:0042537)2.37808135
151regulation of establishment of planar polarity (GO:0090175)2.36348470
152* focal adhesion assembly (GO:0048041)2.34123666
153* cell-substrate adherens junction assembly (GO:0007045)2.34123666
154actin filament depolymerization (GO:0030042)2.33164422
155establishment of apical/basal cell polarity (GO:0035089)2.30792556
156wound healing, spreading of epidermal cells (GO:0035313)2.29056029
157* cell junction organization (GO:0034330)2.28558103
158insulin-like growth factor receptor signaling pathway (GO:0048009)2.27343301
159substrate adhesion-dependent cell spreading (GO:0034446)2.26810916
160sodium ion export (GO:0071436)2.25380564
161lung lobe morphogenesis (GO:0060463)2.24205882
162regulation of axon guidance (GO:1902667)2.23560563
163mammary gland development (GO:0030879)2.23229509
164negative regulation of stem cell proliferation (GO:2000647)2.23090633
165positive regulation of endothelial cell apoptotic process (GO:2000353)2.22411732
166glomerular visceral epithelial cell development (GO:0072015)2.22257362
167apical protein localization (GO:0045176)2.22082711
168extracellular matrix disassembly (GO:0022617)2.21227731
169cell-cell junction assembly (GO:0007043)2.20589868
170cell communication involved in cardiac conduction (GO:0086065)2.18490976
171* adherens junction organization (GO:0034332)2.18356361
172regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.18177163
173atrioventricular valve morphogenesis (GO:0003181)2.14522076
174* regulation of keratinocyte proliferation (GO:0010837)2.13955238
175positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.11809461
176muscle cell migration (GO:0014812)2.11144984
177embryonic retina morphogenesis in camera-type eye (GO:0060059)2.11144227
178regulation of water loss via skin (GO:0033561)2.10876064
179negative regulation of axon guidance (GO:1902668)2.10863990
180sequestering of extracellular ligand from receptor (GO:0035581)2.10757941
181chemical homeostasis within a tissue (GO:0048875)2.10392785
182branching involved in salivary gland morphogenesis (GO:0060445)2.10304739
183negative regulation of cartilage development (GO:0061037)2.10007360
184regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.09357136
185layer formation in cerebral cortex (GO:0021819)2.06486421
186retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.06420091
187collagen metabolic process (GO:0032963)2.05324559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15186693
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.71707080
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.25880577
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.15507921
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.85658866
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.85137187
7* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.53900481
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.14387981
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13910796
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11931405
11CLOCK_20551151_ChIP-Seq_293T_Human2.11009333
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10663141
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07676726
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.96838099
15AR_21909140_ChIP-Seq_LNCAP_Human1.92705677
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83492727
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.78172264
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73769535
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.68293008
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59656815
21* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58706867
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58625230
23ZNF263_19887448_ChIP-Seq_K562_Human1.58336059
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.57808439
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52098287
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51894020
27* EP300_21415370_ChIP-Seq_HL-1_Mouse1.51878056
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.50556764
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.48374054
30BRD4_25478319_ChIP-Seq_HGPS_Human1.46764930
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45036096
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.43488784
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40608517
34* FOXO3_23340844_ChIP-Seq_DLD1_Human1.37920156
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36669737
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36669737
37AHR_22903824_ChIP-Seq_MCF-7_Human1.36045552
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33146326
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30078614
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28438163
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27168228
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25201244
43* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22862679
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.22632488
45TP53_16413492_ChIP-PET_HCT116_Human1.21454913
46* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19756680
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.19406493
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18751041
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18169774
50* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17951316
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.17361277
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.17148262
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16348827
54YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16275334
55* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16180346
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15895541
57* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15605406
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14631362
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13701854
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13591167
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13535536
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13535536
63* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13509495
64GBX2_23144817_ChIP-Seq_PC3_Human1.12035737
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11905269
66* CJUN_26792858_Chip-Seq_BT549_Human1.10287454
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10108298
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.10036984
69* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09753090
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.09229398
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09022831
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08373663
73SOX2_20726797_ChIP-Seq_SW620_Human1.07907487
74* TP63_23658742_ChIP-Seq_EP156T_Human1.07770592
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06918023
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06584745
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04987123
78TP53_18474530_ChIP-ChIP_U2OS_Human1.04479488
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04388777
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04165252
81GATA4_25053715_ChIP-Seq_YYC3_Human1.03838085
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03374002
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.02644484
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02283562
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01769826
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01496008
87* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01270829
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01263834
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00470302
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00051075
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99930337
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99676946
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99389110
94TBX20_22328084_ChIP-Seq_HEART_Mouse0.99166945
95TBX20_22080862_ChIP-Seq_HEART_Mouse0.99166945
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98726734
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98351854
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.98046886
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97500059
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97285267
101* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96856694
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96340838
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96112548
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95868049
105AR_21572438_ChIP-Seq_LNCaP_Human0.95778884
106TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95633682
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95298423
108TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94996053
109GATA6_25053715_ChIP-Seq_YYC3_Human0.94707158
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94506283
111* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94498736
112* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94498736
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.94445611
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.94370301
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94166990
116MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92527558
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92475035
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92384205
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.92285310
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92219038
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92188578
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92097211
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90287041
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.90281775
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89906440
126JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89485611
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89319122
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.89223001
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88268241
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87956757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.02259552
2MP0002139_abnormal_hepatobiliary_system4.73439874
3MP0005085_abnormal_gallbladder_physiolo3.97772905
4MP0005365_abnormal_bile_salt3.53214350
5MP0003252_abnormal_bile_duct3.10387645
6MP0003705_abnormal_hypodermis_morpholog3.06213519
7MP0010234_abnormal_vibrissa_follicle2.93196151
8MP0008875_abnormal_xenobiotic_pharmacok2.79610794
9MP0000537_abnormal_urethra_morphology2.68433739
10MP0005257_abnormal_intraocular_pressure2.41153976
11MP0009053_abnormal_anal_canal2.16590756
12MP0003806_abnormal_nucleotide_metabolis2.11310704
13MP0004272_abnormal_basement_membrane2.02551796
14MP0005409_darkened_coat_color2.02283125
15MP0003950_abnormal_plasma_membrane1.91641847
16MP0001666_abnormal_nutrient_absorption1.88492606
17MP0010329_abnormal_lipoprotein_level1.86519387
18MP0005083_abnormal_biliary_tract1.85694680
19MP0005623_abnormal_meninges_morphology1.76673143
20MP0010368_abnormal_lymphatic_system1.76083054
21MP0008438_abnormal_cutaneous_collagen1.75737892
22MP0005332_abnormal_amino_acid1.75235026
23MP0009384_cardiac_valve_regurgitation1.71072473
24MP0003283_abnormal_digestive_organ1.65174527
25MP0004019_abnormal_vitamin_homeostasis1.62161966
26MP0009780_abnormal_chondrocyte_physiolo1.54769846
27MP0010030_abnormal_orbit_morphology1.49293694
28MP0003195_calcinosis1.44263304
29MP0002138_abnormal_hepatobiliary_system1.43145876
30MP0006054_spinal_hemorrhage1.41658017
31MP0002089_abnormal_postnatal_growth/wei1.34788197
32MP0005275_abnormal_skin_tensile1.34314885
33MP0010678_abnormal_skin_adnexa1.32999998
34MP0003868_abnormal_feces_composition1.29429890
35MP0005248_abnormal_Harderian_gland1.29376956
36MP0002896_abnormal_bone_mineralization1.24976288
37MP0010352_gastrointestinal_tract_polyps1.23438921
38MP0005187_abnormal_penis_morphology1.22519491
39MP0000534_abnormal_ureter_morphology1.20823663
40MP0000566_synostosis1.18569538
41MP0000462_abnormal_digestive_system1.18540081
42MP0000767_abnormal_smooth_muscle1.17229060
43MP0003115_abnormal_respiratory_system1.16862395
44MP0002877_abnormal_melanocyte_morpholog1.14380685
45MP0005076_abnormal_cell_differentiation1.11595088
46MP0000579_abnormal_nail_morphology1.10540010
47MP0003937_abnormal_limbs/digits/tail_de1.10436500
48MP0003941_abnormal_skin_development1.09334376
49MP0000762_abnormal_tongue_morphology1.08846176
50MP0004264_abnormal_extraembryonic_tissu1.08804793
51MP0005501_abnormal_skin_physiology1.08368207
52MP0003119_abnormal_digestive_system1.08031848
53MP0003566_abnormal_cell_adhesion1.07164850
54MP0003279_aneurysm1.06768150
55MP0001849_ear_inflammation1.06658417
56MP0001216_abnormal_epidermal_layer1.04912555
57MP0003942_abnormal_urinary_system1.01311640
58MP0002118_abnormal_lipid_homeostasis1.00788786
59MP0003315_abnormal_perineum_morphology1.00549301
60MP0000751_myopathy0.95983787
61MP0000627_abnormal_mammary_gland0.95866315
62MP0002796_impaired_skin_barrier0.95638221
63MP0003385_abnormal_body_wall0.95327597
64MP0002249_abnormal_larynx_morphology0.95041204
65MP0002254_reproductive_system_inflammat0.94522518
66MP0001915_intracranial_hemorrhage0.94422272
67MP0001958_emphysema0.94282686
68MP0000538_abnormal_urinary_bladder0.91592406
69MP0005197_abnormal_uvea_morphology0.91333414
70MP0000467_abnormal_esophagus_morphology0.90380191
71MP0002295_abnormal_pulmonary_circulatio0.90256200
72MP0010771_integument_phenotype0.89604366
73MP0003890_abnormal_embryonic-extraembry0.89252318
74MP0001879_abnormal_lymphatic_vessel0.88071010
75MP0000609_abnormal_liver_physiology0.87139492
76MP0004270_analgesia0.86852701
77MP0002932_abnormal_joint_morphology0.86294444
78MP0002282_abnormal_trachea_morphology0.86118201
79MP0000516_abnormal_urinary_system0.85621541
80MP0005367_renal/urinary_system_phenotyp0.85621541
81MP0004782_abnormal_surfactant_physiolog0.85336108
82MP0002697_abnormal_eye_size0.84486857
83MP0000377_abnormal_hair_follicle0.83796431
84MP0005503_abnormal_tendon_morphology0.83616672
85MP0004858_abnormal_nervous_system0.81371280
86MP0009643_abnormal_urine_homeostasis0.81306400
87MP0002234_abnormal_pharynx_morphology0.81196132
88MP0009840_abnormal_foam_cell0.81092559
89MP0003329_amyloid_beta_deposits0.80701273
90MP0004885_abnormal_endolymph0.80285594
91MP0001299_abnormal_eye_distance/0.79663495
92MP0000013_abnormal_adipose_tissue0.79020989
93MP0003935_abnormal_craniofacial_develop0.78957795
94MP0004133_heterotaxia0.78570436
95MP0002060_abnormal_skin_morphology0.78526709
96MP0003091_abnormal_cell_migration0.78255754
97MP0005319_abnormal_enzyme/_coenzyme0.76597359
98MP0003755_abnormal_palate_morphology0.76447769
99MP0002168_other_aberrant_phenotype0.76226570
100MP0000733_abnormal_muscle_development0.75944673
101MP0002108_abnormal_muscle_morphology0.75331801
102MP0005167_abnormal_blood-brain_barrier0.75106173
103MP0005023_abnormal_wound_healing0.74867282
104MP0002092_abnormal_eye_morphology0.73355690
105MP0005084_abnormal_gallbladder_morpholo0.73317482
106MP0006138_congestive_heart_failure0.73245083
107MP0002233_abnormal_nose_morphology0.73175865
108MP0003453_abnormal_keratinocyte_physiol0.73086756
109MP0001177_atelectasis0.71808618
110MP0001340_abnormal_eyelid_morphology0.71675145
111MP0000163_abnormal_cartilage_morphology0.71604567
112MP0005220_abnormal_exocrine_pancreas0.71439915
113MP0004233_abnormal_muscle_weight0.70538836
114MP0002925_abnormal_cardiovascular_devel0.69873767
115MP0000003_abnormal_adipose_tissue0.69717963
116MP0005508_abnormal_skeleton_morphology0.68926975
117MP0001286_abnormal_eye_development0.67767242
118MP0003191_abnormal_cellular_cholesterol0.67636931
119MP0000383_abnormal_hair_follicle0.67550445
120MP0004134_abnormal_chest_morphology0.67388362
121MP0002116_abnormal_craniofacial_bone0.67137728
122MP0000778_abnormal_nervous_system0.66506377
123MP0000428_abnormal_craniofacial_morphol0.66343968
124MP0002111_abnormal_tail_morphology0.66300438
125MP0003300_gastrointestinal_ulcer0.65503629
126MP0002086_abnormal_extraembryonic_tissu0.64909017
127MP0000427_abnormal_hair_cycle0.63251110
128MP0009250_abnormal_appendicular_skeleto0.61690840
129MP0001348_abnormal_lacrimal_gland0.61611290
130MP0002098_abnormal_vibrissa_morphology0.61060223
131MP0001346_abnormal_lacrimal_gland0.60781447
132MP0002928_abnormal_bile_duct0.60364517
133MP0002084_abnormal_developmental_patter0.60327569
134MP0008004_abnormal_stomach_pH0.60320019
135MP0005666_abnormal_adipose_tissue0.59734880
136MP0000432_abnormal_head_morphology0.59628151

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.77104455
2Intrahepatic cholestasis (HP:0001406)4.65126647
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96379054
4Arterial tortuosity (HP:0005116)3.71990884
5Xanthomatosis (HP:0000991)3.58788677
6Vascular tortuosity (HP:0004948)3.54365441
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.49196586
8Milia (HP:0001056)3.48899685
9Right ventricular cardiomyopathy (HP:0011663)3.24669702
10Hypobetalipoproteinemia (HP:0003563)3.18968453
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.18556137
12Onycholysis (HP:0001806)3.03378380
13Fragile nails (HP:0001808)2.95250422
14Shallow orbits (HP:0000586)2.93455549
15Lymphangioma (HP:0100764)2.83385087
16Epidermoid cyst (HP:0200040)2.79253471
17Cervical subluxation (HP:0003308)2.76205501
18Coronal craniosynostosis (HP:0004440)2.73162507
19Hypolipoproteinemia (HP:0010981)2.65486947
20Gout (HP:0001997)2.65344721
21Focal segmental glomerulosclerosis (HP:0000097)2.64249773
22Pterygium (HP:0001059)2.59594473
23Glomerulosclerosis (HP:0000096)2.57649808
24Hypoalphalipoproteinemia (HP:0003233)2.55212032
25Hepatoblastoma (HP:0002884)2.54148891
26Cardiovascular calcification (HP:0011915)2.54078907
27Natal tooth (HP:0000695)2.53867751
28Protrusio acetabuli (HP:0003179)2.53349433
29Premature rupture of membranes (HP:0001788)2.52607155
30Turricephaly (HP:0000262)2.49950134
31Hyperammonemia (HP:0001987)2.49175037
32Hepatocellular carcinoma (HP:0001402)2.49040888
33Vascular calcification (HP:0004934)2.46085194
34Hyperlipoproteinemia (HP:0010980)2.44692089
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.42946466
36Complement deficiency (HP:0004431)2.42554717
37Spastic diplegia (HP:0001264)2.41105992
38Ketosis (HP:0001946)2.39864189
39Plantar hyperkeratosis (HP:0007556)2.38136202
40Esophageal varix (HP:0002040)2.37706190
41Abnormality of carpal bone ossification (HP:0006257)2.37445896
42Short nail (HP:0001799)2.37445075
43Fat malabsorption (HP:0002630)2.34371545
44Abnormality of glycine metabolism (HP:0010895)2.33983816
45Abnormality of serine family amino acid metabolism (HP:0010894)2.33983816
46Advanced eruption of teeth (HP:0006288)2.33767622
47Ulnar bowing (HP:0003031)2.32559150
48Hyperglycinuria (HP:0003108)2.32330143
49Prolonged partial thromboplastin time (HP:0003645)2.31916931
50Back pain (HP:0003418)2.30816368
51Bladder diverticulum (HP:0000015)2.28856053
52Ankle contracture (HP:0006466)2.28816172
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27513494
54Hyperglycinemia (HP:0002154)2.27136063
55Mitral stenosis (HP:0001718)2.25708558
56Atrophic scars (HP:0001075)2.25434065
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23743579
58Wormian bones (HP:0002645)2.23595833
59Abnormality of nail color (HP:0100643)2.20571464
60Alopecia of scalp (HP:0002293)2.15042081
61Abnormal ossification of hand bones (HP:0005921)2.13683617
62Follicular hyperkeratosis (HP:0007502)2.12434357
63Abnormality of dentin (HP:0010299)2.09026964
64Vertebral arch anomaly (HP:0008438)2.08934545
65Hypoplasia of dental enamel (HP:0006297)2.08212832
66Asymmetry of the thorax (HP:0001555)2.07730372
67Bronchomalacia (HP:0002780)2.07521490
68Abnormality of the common coagulation pathway (HP:0010990)2.05308216
69Ketoacidosis (HP:0001993)2.00323394
70Spinal rigidity (HP:0003306)1.97818784
71Malnutrition (HP:0004395)1.95982726
72Thick nail (HP:0001805)1.94893236
73Enlarged kidneys (HP:0000105)1.94254832
74Broad face (HP:0000283)1.91149591
75Osteolytic defects of the hand bones (HP:0009699)1.90282576
76Osteolytic defects of the phalanges of the hand (HP:0009771)1.90282576
77Abnormal hand bone ossification (HP:0010660)1.88053884
78Broad metatarsal (HP:0001783)1.86873864
79Hypoglycemic coma (HP:0001325)1.86357928
80Abnormality of purine metabolism (HP:0004352)1.86165852
81Hydroxyprolinuria (HP:0003080)1.84832385
82Abnormality of proline metabolism (HP:0010907)1.84832385
83Abnormality of the acetabulum (HP:0003170)1.84169601
84Soft skin (HP:0000977)1.83860876
85Abnormality of the Achilles tendon (HP:0005109)1.83707292
86Mitral valve prolapse (HP:0001634)1.83554925
87Nail dystrophy (HP:0008404)1.82624494
88Selective tooth agenesis (HP:0001592)1.82520232
89Delayed CNS myelination (HP:0002188)1.81958432
90Subacute progressive viral hepatitis (HP:0006572)1.81635423
91Mildly elevated creatine phosphokinase (HP:0008180)1.80997104
92Absent frontal sinuses (HP:0002688)1.80721999
93Neonatal death (HP:0003811)1.80677746
94Buphthalmos (HP:0000557)1.79516218
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.79404509
96Abnormality of methionine metabolism (HP:0010901)1.79021974
97Rickets (HP:0002748)1.78884578
98Increased purine levels (HP:0004368)1.78531824
99Hyperuricemia (HP:0002149)1.78531824
100Vertebral compression fractures (HP:0002953)1.77223023
101Skin nodule (HP:0200036)1.76422002
102Infantile muscular hypotonia (HP:0008947)1.75357234
103Spinal cord compression (HP:0002176)1.74839554
104Overgrowth (HP:0001548)1.74284475
105Abnormality of the lower motor neuron (HP:0002366)1.73792261
106Abnormality of the intrinsic pathway (HP:0010989)1.73313945
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72767177
108Hypercholesterolemia (HP:0003124)1.72600046
109Microglossia (HP:0000171)1.72407845
110Absent eyelashes (HP:0000561)1.70342965
111Abnormality of nucleobase metabolism (HP:0010932)1.69966084
112Arnold-Chiari malformation (HP:0002308)1.68395879
113Wide anterior fontanel (HP:0000260)1.67172856
114Abnormality of complement system (HP:0005339)1.66952287
115Joint laxity (HP:0001388)1.65818251
116Hyperacusis (HP:0010780)1.65784107
117Blue sclerae (HP:0000592)1.65616425
118Cerebral inclusion bodies (HP:0100314)1.65503692
119Limited hip movement (HP:0008800)1.65480293
120Pseudobulbar signs (HP:0002200)1.64740962
121Chorioretinal atrophy (HP:0000533)1.63845068
122Abnormal delivery (HP:0001787)1.63660684
123Tibial bowing (HP:0002982)1.62495755
124Abnormal cartilage morphology (HP:0002763)1.62357241
125Aneurysm (HP:0002617)1.62342658
126Pili torti (HP:0003777)1.61163283
127Abnormality of oral frenula (HP:0000190)1.60996739
128Cerebral aneurysm (HP:0004944)1.60507799
129Renal duplication (HP:0000075)1.59942935
130Abnormality of the 4th metacarpal (HP:0010012)1.59422479
131Neonatal short-limb short stature (HP:0008921)1.58968526
132Fragile skin (HP:0001030)1.58808331
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.57749962
134Short 4th metacarpal (HP:0010044)1.57749962
135Short hallux (HP:0010109)1.57697114
136Termporal pattern (HP:0011008)1.57550130
137Insidious onset (HP:0003587)1.57550130
138Ridged nail (HP:0001807)1.57269815
139Aortic dissection (HP:0002647)1.57097247
140Flat acetabular roof (HP:0003180)1.56932321
141Popliteal pterygium (HP:0009756)1.56839652
142Elbow flexion contracture (HP:0002987)1.56432795
143Upper limb amyotrophy (HP:0009129)1.55665457
144Distal upper limb amyotrophy (HP:0007149)1.55665457
145Hypoplastic ischia (HP:0003175)1.55222197
146Syringomyelia (HP:0003396)1.55038853
147Spinal cord lesions (HP:0100561)1.55038853
148Rectal prolapse (HP:0002035)1.54728498
149Aplasia involving bones of the extremities (HP:0009825)1.54679027
150Aplasia involving bones of the upper limbs (HP:0009823)1.54679027
151Aplasia of the phalanges of the hand (HP:0009802)1.54679027
152Ileus (HP:0002595)1.54426665
153Limited elbow extension (HP:0001377)1.54294538
154Hyperextensible skin (HP:0000974)1.54009410
155Abnormality of the nasal septum (HP:0000419)1.53652973
156Neurofibrillary tangles (HP:0002185)1.53143971
157Abnormality of the ischium (HP:0003174)1.52881358
158Vertebral clefting (HP:0008428)1.52859425
159Hypophosphatemic rickets (HP:0004912)1.52163763
160Myocardial infarction (HP:0001658)1.51433986
161Ankyloglossia (HP:0010296)1.51315972
162Conjugated hyperbilirubinemia (HP:0002908)1.50688934
163Aortic aneurysm (HP:0004942)1.50271373
164Steatorrhea (HP:0002570)1.49847821
165Coxa vara (HP:0002812)1.49194775
166Heterotopia (HP:0002282)1.48808736
167Knee flexion contracture (HP:0006380)1.48391792
168Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.47752580
169Mitral regurgitation (HP:0001653)1.46948785
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.44826935
171Palmoplantar hyperkeratosis (HP:0000972)1.40923070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.75044167
2EPHA23.74709925
3DDR22.93609071
4FRK2.61902913
5SIK12.49619409
6FGFR22.46036608
7LATS22.28572117
8PDGFRA2.11647890
9MYLK2.11306079
10EPHB22.05780648
11PKN21.93442114
12MET1.89796225
13TTN1.89673087
14RIPK11.88111437
15FER1.86996043
16STK391.80963488
17CASK1.77855225
18WNK41.69377455
19PTK21.68925695
20ERBB41.65801532
21PTK61.61022840
22TRIB31.60471164
23MARK11.58817498
24DAPK21.53088673
25PAK31.50417580
26BCKDK1.50078194
27STK38L1.46581749
28MST1R1.45553451
29OXSR11.36534615
30SCYL21.34232630
31FGFR41.30198626
32MAP3K121.21268771
33BMX1.18972498
34FGFR11.18670090
35PAK21.13180113
36TESK11.07110547
37ERBB21.02985518
38ICK1.02968111
39LMTK21.01219604
40BCR1.00892639
41TYRO30.99869284
42LIMK10.99094882
43EPHA40.97609838
44MAP3K90.97158091
45MAP3K20.97026882
46SMG10.93691260
47KSR10.93216466
48MTOR0.93188928
49EEF2K0.91729233
50TGFBR20.90440812
51PAK40.86834917
52NEK60.85185238
53PAK60.84039021
54CAMK1D0.83888627
55WNK30.83568856
56MAP2K40.83149285
57CAMK1G0.82710633
58DMPK0.81623052
59PIK3CA0.80437415
60NTRK10.80305167
61AKT30.80264196
62EPHA30.80026124
63KSR20.79165767
64PBK0.79029341
65MAP3K100.78633830
66PDGFRB0.77688278
67STK30.77286967
68CSNK1A1L0.76712139
69MAP3K70.76285632
70NEK90.74050597
71STK380.73676819
72STK240.72494384
73MELK0.71755145
74RET0.70581651
75ROCK10.68954913
76TIE10.68298526
77ERN10.67537800
78KDR0.65363899
79GSK3A0.65223970
80MAP2K10.64505590
81CDK120.64077313
82RPS6KA20.63089045
83EPHB10.62850922
84NEK10.62765817
85CAMKK10.61227951
86PHKG10.61220694
87PHKG20.61220694
88DYRK1B0.60431649
89FLT30.59664958
90PRKG20.59450767
91CDK60.59277338
92ARAF0.58846897
93MAP3K40.56857964
94ILK0.55454780
95PTK2B0.55401737
96CDC42BPA0.55361507
97TRPM70.54510477
98WNK10.53077821
99INSRR0.53022489
100MAPKAPK30.51308196
101CSNK1E0.50568567
102CSNK1G20.49078070
103PRKD30.48799555
104ERBB30.47894651
105CAMK2B0.47211577
106CSNK1D0.46991719
107CSNK1G10.46933368
108PRKCZ0.46925254
109LRRK20.46894224
110PRKCI0.44748875
111ROCK20.44240523
112CAMK2G0.43412872
113PRKCE0.43327597
114PDK40.41738856
115PDK30.41738856
116SGK30.41720085
117MINK10.40802822
118MAP3K60.40751978
119PRKD10.39834462
120RPS6KB20.39672889
121BRSK20.39579503
122PNCK0.39198493
123FGFR30.39007772
124PDK20.38896462
125CAMK2D0.38610920
126MAP2K20.38396293
127BRSK10.38109668
128MAP3K30.37336322
129DAPK30.37211336
130CDK80.36511437
131TGFBR10.36392561
132NUAK10.36316422
133PRKD20.33020102
134CDK90.32903093
135CDK70.31450138
136SRC0.30573062
137RPS6KB10.29478109
138PIM20.27589244

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.08517692
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.30486413
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95515710
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94268456
5Arginine biosynthesis_Homo sapiens_hsa002202.77607431
6Tryptophan metabolism_Homo sapiens_hsa003802.18347162
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16233689
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15621644
9Fatty acid degradation_Homo sapiens_hsa000712.10938725
10Butanoate metabolism_Homo sapiens_hsa006502.05796683
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03382689
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95681333
13Complement and coagulation cascades_Homo sapiens_hsa046101.91531625
14Bile secretion_Homo sapiens_hsa049761.84910845
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76668381
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73756895
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70628673
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64722022
19Fatty acid metabolism_Homo sapiens_hsa012121.60763786
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60063421
21Chemical carcinogenesis_Homo sapiens_hsa052041.59110865
22Propanoate metabolism_Homo sapiens_hsa006401.56082264
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54483632
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54129902
25PPAR signaling pathway_Homo sapiens_hsa033201.53819157
26Sulfur metabolism_Homo sapiens_hsa009201.45283047
27Histidine metabolism_Homo sapiens_hsa003401.37957721
28Thyroid cancer_Homo sapiens_hsa052161.37313372
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.31931317
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.30514981
31Peroxisome_Homo sapiens_hsa041461.30055486
32Retinol metabolism_Homo sapiens_hsa008301.30002476
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20929997
34Selenocompound metabolism_Homo sapiens_hsa004501.19379466
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17405594
36ECM-receptor interaction_Homo sapiens_hsa045121.14458628
37Fat digestion and absorption_Homo sapiens_hsa049751.14242170
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13975722
39beta-Alanine metabolism_Homo sapiens_hsa004101.13104079
40Phenylalanine metabolism_Homo sapiens_hsa003601.12497611
41Lysine degradation_Homo sapiens_hsa003101.11935127
42Starch and sucrose metabolism_Homo sapiens_hsa005001.08684469
43Hippo signaling pathway_Homo sapiens_hsa043901.08680765
44Pyruvate metabolism_Homo sapiens_hsa006201.07875186
45Vitamin B6 metabolism_Homo sapiens_hsa007501.06977063
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05636328
47Biosynthesis of amino acids_Homo sapiens_hsa012301.04012651
48Tight junction_Homo sapiens_hsa045301.00954470
49Adherens junction_Homo sapiens_hsa045201.00386719
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99341470
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98323555
52Steroid biosynthesis_Homo sapiens_hsa001000.98294978
53Basal cell carcinoma_Homo sapiens_hsa052170.97516305
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96357741
55ErbB signaling pathway_Homo sapiens_hsa040120.95435106
56Carbon metabolism_Homo sapiens_hsa012000.93798436
57Glioma_Homo sapiens_hsa052140.93690527
58Caffeine metabolism_Homo sapiens_hsa002320.92100827
59Tyrosine metabolism_Homo sapiens_hsa003500.91180921
60Arginine and proline metabolism_Homo sapiens_hsa003300.89030467
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88469825
62Sphingolipid metabolism_Homo sapiens_hsa006000.86350784
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86221368
64Melanoma_Homo sapiens_hsa052180.85950288
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83795666
66Protein digestion and absorption_Homo sapiens_hsa049740.83511488
67N-Glycan biosynthesis_Homo sapiens_hsa005100.82503753
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.81318380
69Focal adhesion_Homo sapiens_hsa045100.81254140
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79026920
71Vitamin digestion and absorption_Homo sapiens_hsa049770.79005725
72Chronic myeloid leukemia_Homo sapiens_hsa052200.78280572
73Pathways in cancer_Homo sapiens_hsa052000.78046195
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77647700
75Bladder cancer_Homo sapiens_hsa052190.77212160
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.76105763
77Axon guidance_Homo sapiens_hsa043600.75582854
78Prostate cancer_Homo sapiens_hsa052150.73316542
79Fatty acid biosynthesis_Homo sapiens_hsa000610.72837391
80Pancreatic secretion_Homo sapiens_hsa049720.72631380
81Estrogen signaling pathway_Homo sapiens_hsa049150.69330971
82Fatty acid elongation_Homo sapiens_hsa000620.68088126
83Renin-angiotensin system_Homo sapiens_hsa046140.67094766
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66869119
85Proteoglycans in cancer_Homo sapiens_hsa052050.64915645
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64913795
87Vibrio cholerae infection_Homo sapiens_hsa051100.64582510
88Renal cell carcinoma_Homo sapiens_hsa052110.63105402
89Glutathione metabolism_Homo sapiens_hsa004800.62980133
90Galactose metabolism_Homo sapiens_hsa000520.62184446
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.61988420
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.61543676
93ABC transporters_Homo sapiens_hsa020100.59926238
94Hedgehog signaling pathway_Homo sapiens_hsa043400.59749423
95Inositol phosphate metabolism_Homo sapiens_hsa005620.59538045
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56156415
97Insulin signaling pathway_Homo sapiens_hsa049100.55325674
98Pancreatic cancer_Homo sapiens_hsa052120.55313981
99Choline metabolism in cancer_Homo sapiens_hsa052310.54935841
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54860184
101Circadian rhythm_Homo sapiens_hsa047100.54657995
102Renin secretion_Homo sapiens_hsa049240.53220177
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53074165
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.52347131
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52046275
106Notch signaling pathway_Homo sapiens_hsa043300.50989592
107TGF-beta signaling pathway_Homo sapiens_hsa043500.50915240
108Glycerolipid metabolism_Homo sapiens_hsa005610.49413025
109Amoebiasis_Homo sapiens_hsa051460.49387401
110Dilated cardiomyopathy_Homo sapiens_hsa054140.48604844
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48102093
112Mineral absorption_Homo sapiens_hsa049780.45900590
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43011512
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42381669
115Insulin resistance_Homo sapiens_hsa049310.42286481
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41248551
117Folate biosynthesis_Homo sapiens_hsa007900.40183085
118Melanogenesis_Homo sapiens_hsa049160.39584165
119Thyroid hormone synthesis_Homo sapiens_hsa049180.37929814
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37788092
121Dorso-ventral axis formation_Homo sapiens_hsa043200.37686603
122AMPK signaling pathway_Homo sapiens_hsa041520.37331371
123Prion diseases_Homo sapiens_hsa050200.36505068
124Small cell lung cancer_Homo sapiens_hsa052220.36403941
125Wnt signaling pathway_Homo sapiens_hsa043100.33115390
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.31907791
127Endometrial cancer_Homo sapiens_hsa052130.31552261
128One carbon pool by folate_Homo sapiens_hsa006700.30909368
129Glucagon signaling pathway_Homo sapiens_hsa049220.30805229
130Rap1 signaling pathway_Homo sapiens_hsa040150.29316087
131MicroRNAs in cancer_Homo sapiens_hsa052060.28932463
132Gap junction_Homo sapiens_hsa045400.28743081
133Staphylococcus aureus infection_Homo sapiens_hsa051500.28559084
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22918277
135Gastric acid secretion_Homo sapiens_hsa049710.22523305
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21834905
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21707015

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