PTPRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20258664
2synaptic vesicle maturation (GO:0016188)6.02409137
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.64503955
4locomotory exploration behavior (GO:0035641)5.42472306
5synaptic vesicle exocytosis (GO:0016079)5.10645696
6regulation of synaptic vesicle exocytosis (GO:2000300)4.97190925
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.96930675
8glutamate secretion (GO:0014047)4.81601297
9vocalization behavior (GO:0071625)4.79234440
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.66072918
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.53378928
12regulation of glutamate receptor signaling pathway (GO:1900449)4.45560068
13regulation of synaptic vesicle transport (GO:1902803)4.41901005
14neurotransmitter secretion (GO:0007269)4.31665340
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.31307262
16regulation of neuronal synaptic plasticity (GO:0048168)4.28099622
17neuronal action potential propagation (GO:0019227)4.16030721
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13582968
19regulation of type B pancreatic cell apoptotic process (GO:2000674)4.09590148
20exploration behavior (GO:0035640)4.03957915
21protein localization to synapse (GO:0035418)4.02613438
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.01292071
23activation of protein kinase A activity (GO:0034199)4.01079933
24negative regulation of hormone biosynthetic process (GO:0032353)3.97710479
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87133832
26regulation of synapse structural plasticity (GO:0051823)3.87072943
27proline transport (GO:0015824)3.86410511
28neuron cell-cell adhesion (GO:0007158)3.86130992
29negative regulation of cytosolic calcium ion concentration (GO:0051481)3.84933159
30glycerophospholipid catabolic process (GO:0046475)3.79764910
31positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75824370
32layer formation in cerebral cortex (GO:0021819)3.72772618
33neuromuscular process controlling posture (GO:0050884)3.71173273
34synaptic transmission, glutamatergic (GO:0035249)3.68939128
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67603308
36endocrine pancreas development (GO:0031018)3.67061171
37dendritic spine morphogenesis (GO:0060997)3.64708534
38cerebellar Purkinje cell layer development (GO:0021680)3.61323261
39long-term memory (GO:0007616)3.59288163
40positive regulation of membrane potential (GO:0045838)3.52549135
41neuron-neuron synaptic transmission (GO:0007270)3.49925030
42neurotransmitter transport (GO:0006836)3.47902732
43positive regulation of insulin secretion (GO:0032024)3.46655715
44cellular potassium ion homeostasis (GO:0030007)3.45979509
45gamma-aminobutyric acid transport (GO:0015812)3.45946379
46glutamate receptor signaling pathway (GO:0007215)3.41088274
47regulation of vesicle fusion (GO:0031338)3.40831653
48negative regulation of hormone metabolic process (GO:0032351)3.40089254
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39419369
50chemosensory behavior (GO:0007635)3.37058772
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35911794
52regulation of synaptic plasticity (GO:0048167)3.35845984
53positive regulation of glycolytic process (GO:0045821)3.35239863
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29912110
55neuromuscular process controlling balance (GO:0050885)3.29102563
56neurotransmitter-gated ion channel clustering (GO:0072578)3.28964122
57glycine transport (GO:0015816)3.28108976
58regulation of postsynaptic membrane potential (GO:0060078)3.25411109
59regulation of neurotransmitter secretion (GO:0046928)3.25115889
60negative regulation of protein oligomerization (GO:0032460)3.24614766
61sodium ion export (GO:0071436)3.24346186
62transmission of nerve impulse (GO:0019226)3.23614841
63regulation of neurotransmitter levels (GO:0001505)3.22028674
64detection of calcium ion (GO:0005513)3.21941414
65regulation of insulin secretion (GO:0050796)3.20466805
66nitric oxide mediated signal transduction (GO:0007263)3.18024409
67vesicle transport along microtubule (GO:0047496)3.16959085
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16732007
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15690829
70long-term synaptic potentiation (GO:0060291)3.15409327
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14356240
72response to dietary excess (GO:0002021)3.14081827
73regulation of calcium ion-dependent exocytosis (GO:0017158)3.13837093
74positive regulation of peptide hormone secretion (GO:0090277)3.13423830
75neuron recognition (GO:0008038)3.13350756
76peptide hormone secretion (GO:0030072)3.13081778
77neuronal ion channel clustering (GO:0045161)3.12905280
78regulation of hexokinase activity (GO:1903299)3.11885924
79regulation of glucokinase activity (GO:0033131)3.11885924
80peptide hormone processing (GO:0016486)3.11100850
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10444162
82cell communication by electrical coupling (GO:0010644)3.10423091
83positive regulation of peptide secretion (GO:0002793)3.09642179
84cerebellar Purkinje cell differentiation (GO:0021702)3.07008714
85righting reflex (GO:0060013)3.05794259
86positive regulation of neurotransmitter transport (GO:0051590)3.05096587
87synaptic vesicle endocytosis (GO:0048488)3.04530533
88regulation of neurotransmitter transport (GO:0051588)3.04496577
89regulation of ARF protein signal transduction (GO:0032012)3.04249762
90regulation of dendritic spine morphogenesis (GO:0061001)3.03474351
91innervation (GO:0060384)3.03013429
92membrane depolarization during action potential (GO:0086010)3.01895929
93prepulse inhibition (GO:0060134)3.01578466
94startle response (GO:0001964)3.01469562
95peptide secretion (GO:0002790)3.01200973
96auditory behavior (GO:0031223)3.00267982
97potassium ion homeostasis (GO:0055075)2.99241913
98positive regulation of neurotransmitter secretion (GO:0001956)2.96492611
99insulin secretion (GO:0030073)2.96381011
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.95896912
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.95824566
102inositol phosphate catabolic process (GO:0071545)2.94724692
103response to auditory stimulus (GO:0010996)2.92068920
104regulation of peptide hormone secretion (GO:0090276)2.90920661
105regulation of female receptivity (GO:0045924)2.90029309
106axonal fasciculation (GO:0007413)2.89275310
107positive regulation of synaptic transmission (GO:0050806)2.87043774
108regulation of peptide secretion (GO:0002791)2.86970344
109dendritic spine organization (GO:0097061)2.86928766
110membrane depolarization (GO:0051899)2.85933446
111positive regulation of synapse maturation (GO:0090129)2.85677513
112L-alpha-amino acid transmembrane transport (GO:1902475)2.85602632
113suckling behavior (GO:0001967)2.85058002
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.84809141
115regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.84809141
116social behavior (GO:0035176)2.83916668
117intraspecies interaction between organisms (GO:0051703)2.83916668
118signal release (GO:0023061)2.83723796
119regulation of glutamate secretion (GO:0014048)2.83329309
120mating behavior (GO:0007617)2.82403405
121regulation of neurotransmitter uptake (GO:0051580)2.82042523
122regulation of exocytosis (GO:0017157)2.82003203
123regulation of synaptic transmission (GO:0050804)2.81553854
124positive regulation of meiosis (GO:0045836)2.80407550
125regulation of synaptic transmission, GABAergic (GO:0032228)2.80301950
126calcium ion-dependent exocytosis (GO:0017156)2.80213694
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79671148
128negative regulation of dendrite morphogenesis (GO:0050774)2.79108515
129negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78753054
130synaptic transmission (GO:0007268)2.78715210
131positive regulation of vesicle fusion (GO:0031340)2.78026462
132neuromuscular process (GO:0050905)2.77692791
133cellular ketone body metabolic process (GO:0046950)2.77025137
134membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.76181185
135positive regulation of exocytosis (GO:0045921)2.67156012
136calcium ion import (GO:0070509)2.66726583
137glandular epithelial cell differentiation (GO:0002067)2.64526438
138macroautophagy (GO:0016236)2.61485287
139positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.61141853
140alanine transport (GO:0032328)2.59416850
141negative regulation of glycogen metabolic process (GO:0070874)2.58323595
142negative regulation of gluconeogenesis (GO:0045721)2.57967547
143regulation of hormone secretion (GO:0046883)2.57170139
144positive regulation of meiotic cell cycle (GO:0051446)2.57040917
145cellular potassium ion transport (GO:0071804)2.55732989
146potassium ion transmembrane transport (GO:0071805)2.55732989
147regulation of heart rate by cardiac conduction (GO:0086091)2.54221816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94389027
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09504055
3GBX2_23144817_ChIP-Seq_PC3_Human3.02915530
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99240654
5REST_21632747_ChIP-Seq_MESCs_Mouse2.97373317
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.90094501
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89836136
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64760494
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63355720
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60899344
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60899344
12DROSHA_22980978_ChIP-Seq_HELA_Human2.59024779
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57594116
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54345965
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53669870
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.45102652
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40356038
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39566253
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25176314
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.23918779
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22838952
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.15983266
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.13032850
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07759777
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07581094
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06856353
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05647047
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88058968
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76801798
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.66456874
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61890691
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58200587
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57714456
34SMAD4_21799915_ChIP-Seq_A2780_Human1.53346078
35ZNF274_21170338_ChIP-Seq_K562_Hela1.50749909
36NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48401377
37HTT_18923047_ChIP-ChIP_STHdh_Human1.47247861
38* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43456162
39AR_21572438_ChIP-Seq_LNCaP_Human1.39644287
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38012565
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35863305
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35720562
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35647302
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35062458
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33319289
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.31201615
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27380224
48KDM2B_26808549_Chip-Seq_K562_Human1.26088008
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.25405380
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24457807
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24066384
52AR_19668381_ChIP-Seq_PC3_Human1.23609984
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.21255954
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21242184
55STAT3_23295773_ChIP-Seq_U87_Human1.20749922
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20169722
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.20102238
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20055525
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19853929
60BCAT_22108803_ChIP-Seq_LS180_Human1.18906731
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18202478
62TAF15_26573619_Chip-Seq_HEK293_Human1.16656566
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14492552
64IGF1R_20145208_ChIP-Seq_DFB_Human1.14052643
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.13973597
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10067334
67AR_25329375_ChIP-Seq_VCAP_Human1.09714096
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09146354
69FUS_26573619_Chip-Seq_HEK293_Human1.09010017
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08067234
71P300_19829295_ChIP-Seq_ESCs_Human1.06994394
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05075016
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04943157
74* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04646796
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04498567
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03347598
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03107292
78* P53_22387025_ChIP-Seq_ESCs_Mouse1.02738739
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.02444615
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01972967
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01946423
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01696856
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01057945
84TCF4_23295773_ChIP-Seq_U87_Human1.00990738
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.00981084
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00969346
87* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00502150
88TP53_22573176_ChIP-Seq_HFKS_Human1.00189657
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99903712
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.99800725
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99783992
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99741267
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99683941
94TET1_21490601_ChIP-Seq_MESCs_Mouse0.97505741
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96883326
96* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96544238
97* SOX2_18555785_Chip-Seq_ESCs_Mouse0.96331338
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.95685309
99* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95060901
100CTCF_27219007_Chip-Seq_Bcells_Human0.94886749
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94558180
102CBP_20019798_ChIP-Seq_JUKART_Human0.94558180
103AHR_22903824_ChIP-Seq_MCF-7_Human0.93779617
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93073581
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.92551400
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92025002
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.91620999
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91460373
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90443913
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.90171338
111FLI1_21867929_ChIP-Seq_TH2_Mouse0.90171117
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.90047267
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89550933
114* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88648807
115* E2F1_18555785_Chip-Seq_ESCs_Mouse0.88438958
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88391021
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88162768
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.88159538
119RUNX2_22187159_ChIP-Seq_PCA_Human0.87938682
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87554620
121TCF4_22108803_ChIP-Seq_LS180_Human0.87404552
122* CTCF_18555785_Chip-Seq_ESCs_Mouse0.87162990
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85987197
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85785939
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85309355
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.85001048
127RXR_22108803_ChIP-Seq_LS180_Human0.84872113
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84377626
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83890855
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82104434
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81545707
132RNF2_27304074_Chip-Seq_NSC_Mouse0.81499976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02697282
2MP0003880_abnormal_central_pattern4.00472325
3MP0003635_abnormal_synaptic_transmissio3.90194382
4MP0004270_analgesia3.64135846
5MP0002822_catalepsy3.20932635
6MP0009745_abnormal_behavioral_response3.18681106
7MP0002063_abnormal_learning/memory/cond3.08064287
8MP0002909_abnormal_adrenal_gland3.04142528
9MP0002064_seizures2.91763816
10MP0009780_abnormal_chondrocyte_physiolo2.72004614
11MP0009046_muscle_twitch2.64691228
12MP0002572_abnormal_emotion/affect_behav2.63329832
13MP0001968_abnormal_touch/_nociception2.63245948
14MP0003195_calcinosis2.55097470
15MP0002734_abnormal_mechanical_nocicepti2.47852464
16MP0002272_abnormal_nervous_system2.41442763
17MP0005423_abnormal_somatic_nervous2.40914534
18MP0003283_abnormal_digestive_organ2.37351199
19MP0001501_abnormal_sleep_pattern2.27429530
20MP0008877_abnormal_DNA_methylation2.24557159
21MP0003122_maternal_imprinting2.24130309
22MP0001486_abnormal_startle_reflex2.15948298
23MP0005645_abnormal_hypothalamus_physiol2.07532226
24MP0002733_abnormal_thermal_nociception2.05517437
25MP0001970_abnormal_pain_threshold1.94498573
26MP0000013_abnormal_adipose_tissue1.93426831
27MP0005646_abnormal_pituitary_gland1.92615676
28MP0001440_abnormal_grooming_behavior1.91447133
29MP0002735_abnormal_chemical_nociception1.87992170
30MP0002736_abnormal_nociception_after1.85660580
31MP0004858_abnormal_nervous_system1.83229263
32MP0002163_abnormal_gland_morphology1.73283910
33MP0003787_abnormal_imprinting1.71260870
34MP0003329_amyloid_beta_deposits1.69769925
35MP0004811_abnormal_neuron_physiology1.66527785
36MP0002067_abnormal_sensory_capabilities1.65763528
37MP0008569_lethality_at_weaning1.65440929
38MP0006276_abnormal_autonomic_nervous1.64164483
39MP0002557_abnormal_social/conspecific_i1.62228570
40MP0003879_abnormal_hair_cell1.57954681
41MP0005386_behavior/neurological_phenoty1.56360643
42MP0004924_abnormal_behavior1.56360643
43MP0010386_abnormal_urinary_bladder1.55715780
44MP0002184_abnormal_innervation1.52315309
45MP0008961_abnormal_basal_metabolism1.49349741
46MP0000955_abnormal_spinal_cord1.46981781
47MP0004043_abnormal_pH_regulation1.42277731
48MP0001502_abnormal_circadian_rhythm1.37097850
49MP0002066_abnormal_motor_capabilities/c1.30060848
50MP0003633_abnormal_nervous_system1.28375985
51MP0002882_abnormal_neuron_morphology1.25268554
52MP0001529_abnormal_vocalization1.23638233
53MP0001984_abnormal_olfaction1.23617318
54MP0000778_abnormal_nervous_system1.20502675
55MP0004885_abnormal_endolymph1.20447172
56MP0005448_abnormal_energy_balance1.13461594
57* MP0002693_abnormal_pancreas_physiology1.10212264
58MP0001756_abnormal_urination1.09953847
59MP0005535_abnormal_body_temperature1.06916134
60MP0002837_dystrophic_cardiac_calcinosis1.06332855
61MP0001905_abnormal_dopamine_level1.06269916
62MP0002139_abnormal_hepatobiliary_system1.05966215
63MP0005220_abnormal_exocrine_pancreas1.05446638
64MP0002069_abnormal_eating/drinking_beha1.03964129
65MP0001944_abnormal_pancreas_morphology1.03962849
66MP0004145_abnormal_muscle_electrophysio1.03860420
67MP0005379_endocrine/exocrine_gland_phen1.03056232
68MP0002877_abnormal_melanocyte_morpholog1.02687427
69MP0003631_nervous_system_phenotype1.00924565
70MP0010329_abnormal_lipoprotein_level0.99791186
71MP0002638_abnormal_pupillary_reflex0.98773668
72MP0002928_abnormal_bile_duct0.98639391
73MP0003183_abnormal_peptide_metabolism0.98545111
74MP0003172_abnormal_lysosome_physiology0.97862920
75MP0003123_paternal_imprinting0.97588444
76MP0000639_abnormal_adrenal_gland0.93780515
77MP0004142_abnormal_muscle_tone0.93590425
78MP0002229_neurodegeneration0.93349913
79MP0005332_abnormal_amino_acid0.91951024
80MP0002152_abnormal_brain_morphology0.91062037
81MP0003075_altered_response_to0.89997875
82MP0000631_abnormal_neuroendocrine_gland0.89497348
83MP0004085_abnormal_heartbeat0.88585738
84MP0000751_myopathy0.87768810
85MP0008872_abnormal_physiological_respon0.83211221
86MP0002234_abnormal_pharynx_morphology0.83053191
87MP0000003_abnormal_adipose_tissue0.82866027
88MP0004510_myositis0.82663052
89MP0002078_abnormal_glucose_homeostasis0.82412994
90MP0003634_abnormal_glial_cell0.82262996
91MP0001188_hyperpigmentation0.81403789
92MP0005636_abnormal_mineral_homeostasis0.81010076
93MP0001177_atelectasis0.80268096
94MP0000462_abnormal_digestive_system0.79088110
95MP0001299_abnormal_eye_distance/0.78392670
96MP0010234_abnormal_vibrissa_follicle0.78385663
97MP0008874_decreased_physiological_sensi0.76835900
98MP0005253_abnormal_eye_physiology0.76497099
99MP0006072_abnormal_retinal_apoptosis0.72123512
100MP0001765_abnormal_ion_homeostasis0.71887611
101MP0000678_abnormal_parathyroid_gland0.71833402
102MP0001664_abnormal_digestion0.71495552
103MP0005167_abnormal_blood-brain_barrier0.71319977
104MP0003690_abnormal_glial_cell0.71093571
105MP0003045_fibrosis0.70853303
106MP0002090_abnormal_vision0.70039418
107MP0003953_abnormal_hormone_level0.69516773
108MP0005084_abnormal_gallbladder_morpholo0.69423846
109MP0004133_heterotaxia0.68879279
110MP0002118_abnormal_lipid_homeostasis0.68834645
111MP0003121_genomic_imprinting0.66848240
112MP0003632_abnormal_nervous_system0.65877131
113MP0000604_amyloidosis0.64281059
114MP0005452_abnormal_adipose_tissue0.64204269
115MP0005551_abnormal_eye_electrophysiolog0.63192670
116MP0002876_abnormal_thyroid_physiology0.62018637
117MP0001986_abnormal_taste_sensitivity0.61131807
118MP0000569_abnormal_digit_pigmentation0.60994624
119MP0000920_abnormal_myelination0.60865481

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.59964239
2Myokymia (HP:0002411)6.22596222
3Visual hallucinations (HP:0002367)5.22830814
4Hypoglycemic coma (HP:0001325)5.21630758
5Focal seizures (HP:0007359)5.10368115
6Ketoacidosis (HP:0001993)4.94355813
7Hyperglycemia (HP:0003074)4.51632110
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.35567412
9Atonic seizures (HP:0010819)4.23685474
10Abnormality of endocrine pancreas physiology (HP:0012093)4.15951047
11Abnormality of the pancreatic islet cells (HP:0006476)4.15951047
12Epileptic encephalopathy (HP:0200134)4.00857103
13Papilledema (HP:0001085)3.93876285
14Late onset (HP:0003584)3.89230205
15Absence seizures (HP:0002121)3.88209138
16Large for gestational age (HP:0001520)3.67960370
17Generalized tonic-clonic seizures (HP:0002069)3.63019836
18Insulin-resistant diabetes mellitus (HP:0000831)3.60052398
19Febrile seizures (HP:0002373)3.58146939
20Supranuclear gaze palsy (HP:0000605)3.57656779
21Action tremor (HP:0002345)3.55959684
22Progressive cerebellar ataxia (HP:0002073)3.53174033
23Dialeptic seizures (HP:0011146)3.51258074
24Depression (HP:0000716)3.49304392
25Double outlet right ventricle (HP:0001719)3.32663260
26Congenital malformation of the right heart (HP:0011723)3.32663260
27Anxiety (HP:0000739)3.31169363
28Agitation (HP:0000713)3.28517260
29Ankle clonus (HP:0011448)3.27450394
30Impaired vibration sensation in the lower limbs (HP:0002166)3.13215565
31Hyperthyroidism (HP:0000836)3.03294224
32Ketosis (HP:0001946)3.01323115
33Poor eye contact (HP:0000817)2.92165085
34Truncal ataxia (HP:0002078)2.89756748
35Enlarged penis (HP:0000040)2.89568598
36Intestinal atresia (HP:0011100)2.86196537
37Prominent metopic ridge (HP:0005487)2.86088335
38Pheochromocytoma (HP:0002666)2.83203934
39Hypothermia (HP:0002045)2.83192457
40Epileptiform EEG discharges (HP:0011182)2.81125480
41Hypomagnesemia (HP:0002917)2.79979125
42Postural instability (HP:0002172)2.79779163
43Dysmetria (HP:0001310)2.76641341
44EEG with generalized epileptiform discharges (HP:0011198)2.75467341
45Abnormal social behavior (HP:0012433)2.73883176
46Impaired social interactions (HP:0000735)2.73883176
47Impaired smooth pursuit (HP:0007772)2.73236838
48Urinary bladder sphincter dysfunction (HP:0002839)2.72420424
49Ventricular fibrillation (HP:0001663)2.71268242
50Abnormality of calcium-phosphate metabolism (HP:0100530)2.70440087
51Dysdiadochokinesis (HP:0002075)2.70192556
52Abnormal eating behavior (HP:0100738)2.68389759
53Hypercortisolism (HP:0001578)2.68142637
54Hypsarrhythmia (HP:0002521)2.67962323
55Hypokinesia (HP:0002375)2.66486222
56Amblyopia (HP:0000646)2.64393424
57Pancreatic islet-cell hyperplasia (HP:0004510)2.63901878
58Muscular hypotonia of the trunk (HP:0008936)2.59669695
59Gaze-evoked nystagmus (HP:0000640)2.59452392
60Broad-based gait (HP:0002136)2.58522137
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58293363
62Polyphagia (HP:0002591)2.54917294
63Abnormality of the metopic suture (HP:0005556)2.53373311
64Hyperinsulinemic hypoglycemia (HP:0000825)2.50523274
65Failure to thrive in infancy (HP:0001531)2.49541284
66Cerebral inclusion bodies (HP:0100314)2.48154373
67Menstrual irregularities (HP:0000858)2.47899995
68Genetic anticipation (HP:0003743)2.44605715
69Abnormality of the lower motor neuron (HP:0002366)2.43759964
70Diminished movement (HP:0002374)2.42360539
71Torticollis (HP:0000473)2.41410409
72Bradykinesia (HP:0002067)2.40828572
73Neurofibrillary tangles (HP:0002185)2.40583977
74Hyperphosphatemia (HP:0002905)2.39764105
75Neuroendocrine neoplasm (HP:0100634)2.38550395
76Spastic gait (HP:0002064)2.36004713
77Abnormal pancreas size (HP:0012094)2.35963660
78Hemiparesis (HP:0001269)2.32510402
79Resting tremor (HP:0002322)2.29495230
80Poor suck (HP:0002033)2.26599880
81Abnormality of magnesium homeostasis (HP:0004921)2.25465389
82Hemiplegia (HP:0002301)2.24180362
83Focal dystonia (HP:0004373)2.23619276
84Abnormality of ocular smooth pursuit (HP:0000617)2.22386746
85Drooling (HP:0002307)2.20449686
86Excessive salivation (HP:0003781)2.20449686
87Urinary urgency (HP:0000012)2.19495395
88Hyperventilation (HP:0002883)2.17688751
89Megalencephaly (HP:0001355)2.16340882
90Insomnia (HP:0100785)2.16225003
91Hypoventilation (HP:0002791)2.16189520
92Mutism (HP:0002300)2.16005800
93Intention tremor (HP:0002080)2.14728658
94Testicular neoplasm (HP:0010788)2.14072813
95Limb dystonia (HP:0002451)2.12345091
96Unilateral renal agenesis (HP:0000122)2.11363912
97Scanning speech (HP:0002168)2.10636770
98Akinesia (HP:0002304)2.10214091
99Insulin resistance (HP:0000855)2.09861623
100Hypoglycemic seizures (HP:0002173)2.09262267
101Neuronal loss in central nervous system (HP:0002529)2.09018300
102Bundle branch block (HP:0011710)2.07047852
103Decreased circulating renin level (HP:0003351)2.05807948
104Stereotypic behavior (HP:0000733)2.04138103
105Psychosis (HP:0000709)2.02532696
106Ankyloglossia (HP:0010296)2.01971980
107Polydipsia (HP:0001959)2.00937301
108Abnormal drinking behavior (HP:0030082)2.00937301
109Abnormal EKG (HP:0003115)2.00542385
110Postural tremor (HP:0002174)2.00393594
111Diplopia (HP:0000651)1.99721614
112Abnormality of binocular vision (HP:0011514)1.99721614
113Craniofacial dystonia (HP:0012179)1.99199394
114Sleep apnea (HP:0010535)1.97001873
115Lower limb muscle weakness (HP:0007340)1.94674587
116Impaired vibratory sensation (HP:0002495)1.94499692
117Macroorchidism (HP:0000053)1.94424951
118Progressive inability to walk (HP:0002505)1.93461365
119Clonus (HP:0002169)1.92784712
120Abnormal sex determination (HP:0012244)1.90501741
121Sex reversal (HP:0012245)1.90501741
122Status epilepticus (HP:0002133)1.90039858
123Increased circulating renin level (HP:0000848)1.89508483
124Nuclear cataract (HP:0100018)1.89292194
125Neoplasm of the heart (HP:0100544)1.89092440
126Hyperparathyroidism (HP:0000843)1.88686649
127Termporal pattern (HP:0011008)1.87733309
128Insidious onset (HP:0003587)1.87733309
129Restlessness (HP:0000711)1.87386554
130Gait ataxia (HP:0002066)1.86881999
131Dysmetric saccades (HP:0000641)1.86496346
132Symptomatic seizures (HP:0011145)1.85995590
133Prolonged QT interval (HP:0001657)1.85460596
134Tongue fasciculations (HP:0001308)1.85256778
135Rapidly progressive (HP:0003678)1.84128663
136J-shaped sella turcica (HP:0002680)1.83747927
137Pointed chin (HP:0000307)1.82206352
138Rigidity (HP:0002063)1.82112140
139Aqueductal stenosis (HP:0002410)1.81801050
140Generalized myoclonic seizures (HP:0002123)1.80710163
141Neoplasm of the peripheral nervous system (HP:0100007)1.80472608
142Retinal atrophy (HP:0001105)1.77379678
143Abnormality of vitamin B metabolism (HP:0004340)1.77367973
144Increased CSF protein (HP:0002922)1.74222403
145Abnormality of renin-angiotensin system (HP:0000847)1.70634697
146Type I diabetes mellitus (HP:0100651)1.70103487
147Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66461061
148Abnormality of polysaccharide metabolism (HP:0011012)1.66461061
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66461061
150Medial flaring of the eyebrow (HP:0010747)1.64018983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.05752385
2EPHA44.20589926
3MAP3K93.82428524
4PRKD32.96138105
5MAP3K42.64288313
6FGFR22.52179089
7NTRK12.49652263
8MINK12.42306562
9KSR22.41362523
10MAP4K22.33871415
11DAPK22.33638797
12PAK62.22648245
13MAP2K72.00827040
14MARK11.97084733
15MAP3K21.96836882
16CAMKK11.95228301
17NTRK21.82065446
18MAP3K121.75447291
19UHMK11.72291389
20MAP2K61.70946830
21MAP2K41.66916277
22RIPK41.57480978
23CDK51.56905485
24ARAF1.51651190
25MAP3K11.40673803
26MST41.39920773
27FGFR31.38219743
28GRK51.37892965
29CAMKK21.37829550
30DAPK11.37665806
31EPHA31.37235487
32PNCK1.35401226
33INSRR1.33234645
34KSR11.32110786
35PRKCH1.28942864
36MAP3K131.27542251
37STK381.27161707
38GRK11.15923354
39TNIK1.15345456
40PRKCG1.14397413
41TAOK11.13792161
42FES1.13403963
43SCYL21.11458483
44PLK21.08095085
45RET1.05575407
46PAK31.01146504
47SIK20.99954218
48CDK190.99591957
49ALK0.99541124
50ADRBK20.98742102
51TYRO30.98588565
52CASK0.98480983
53CAMK2A0.96675679
54CAMK10.95589006
55TRPM70.94381579
56CDC42BPA0.92320703
57HIPK20.91681113
58STK38L0.87623598
59CSNK1G10.86733804
60MARK20.86212514
61STK110.85997997
62SGK2230.82870410
63SGK4940.82870410
64TAOK30.82852236
65CSNK1G30.82526199
66CAMK2B0.82321079
67MAPK130.81106517
68NLK0.80382225
69CDK180.77533186
70CDK150.76999244
71CDK140.76677143
72PRPF4B0.76588893
73TRIM280.73138030
74LIMK10.68675867
75PRKAA10.67383362
76CDK11A0.65795066
77FER0.65333067
78PDGFRA0.65225672
79CAMK1G0.64536889
80WNK30.64526397
81SGK10.64491800
82SGK30.64329672
83WNK10.63994158
84PDPK10.63987431
85CAMK2D0.62962824
86LATS20.62281452
87TNK20.61688255
88PDK10.61586468
89SGK20.60643087
90PINK10.60360976
91RAF10.59473643
92PRKCI0.58127212
93WNK40.57856577
94PTK2B0.56583807
95RIPK10.56187809
96BMPR20.55856435
97CSNK1G20.55628136
98PRKD20.55404195
99BRSK10.55247327
100PRKCE0.54648044
101PASK0.54500665
102YES10.54401456
103PHKG20.54041871
104PHKG10.54041871
105RPS6KA30.52139992
106LMTK20.50839699
107PRKCZ0.49464411
108DYRK1A0.49106298
109NEK60.48943992
110MAP2K10.48164592
111PTK20.47365952
112MAPK100.46874656
113CAMK2G0.46635349
114BRAF0.43790607
115PRKG20.43768349
116STK30.43467595
117TESK10.42980429
118AKT30.42388437
119PRKACA0.42382016
120OXSR10.42092655
121PRKG10.40524330
122DAPK30.40324412
123CSNK1A10.40207838
124FRK0.40107344
125FYN0.39586096
126PRKCA0.39282784
127CSNK1A1L0.37505734
128PRKAA20.37045307
129RPS6KA20.36744592
130STK390.35966032
131EPHB10.35889017
132IRAK20.35016702

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.22890067
2Nicotine addiction_Homo sapiens_hsa050333.06352011
3Insulin secretion_Homo sapiens_hsa049112.71455210
4GABAergic synapse_Homo sapiens_hsa047272.63596005
5Amphetamine addiction_Homo sapiens_hsa050312.60624028
6Circadian entrainment_Homo sapiens_hsa047132.57258649
7Olfactory transduction_Homo sapiens_hsa047402.52299830
8Long-term potentiation_Homo sapiens_hsa047202.52106227
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43778140
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38953256
11Morphine addiction_Homo sapiens_hsa050322.36046551
12Glutamatergic synapse_Homo sapiens_hsa047242.31313861
13Dopaminergic synapse_Homo sapiens_hsa047282.17756075
14Cocaine addiction_Homo sapiens_hsa050302.10719784
15Salivary secretion_Homo sapiens_hsa049701.97630175
16Cholinergic synapse_Homo sapiens_hsa047251.93126706
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92120262
18Butanoate metabolism_Homo sapiens_hsa006501.87773140
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85639706
20Gastric acid secretion_Homo sapiens_hsa049711.82997898
21Vitamin B6 metabolism_Homo sapiens_hsa007501.79106055
22Taste transduction_Homo sapiens_hsa047421.76505053
23Type II diabetes mellitus_Homo sapiens_hsa049301.73420314
24Renin secretion_Homo sapiens_hsa049241.62914810
25Serotonergic synapse_Homo sapiens_hsa047261.62738370
26Protein export_Homo sapiens_hsa030601.62453888
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62364908
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.59322433
29Long-term depression_Homo sapiens_hsa047301.56796043
30Collecting duct acid secretion_Homo sapiens_hsa049661.48207670
31Oxytocin signaling pathway_Homo sapiens_hsa049211.47488637
32Calcium signaling pathway_Homo sapiens_hsa040201.41688858
33GnRH signaling pathway_Homo sapiens_hsa049121.40992476
34Vibrio cholerae infection_Homo sapiens_hsa051101.40106219
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35110011
36Regulation of autophagy_Homo sapiens_hsa041401.31616412
37Gap junction_Homo sapiens_hsa045401.29384889
38Estrogen signaling pathway_Homo sapiens_hsa049151.25867648
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25463911
40cAMP signaling pathway_Homo sapiens_hsa040241.24638402
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18867150
42Oxidative phosphorylation_Homo sapiens_hsa001901.12637563
43Pancreatic secretion_Homo sapiens_hsa049721.12310405
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10479623
45Sulfur metabolism_Homo sapiens_hsa009201.09554436
46Glioma_Homo sapiens_hsa052141.07637172
47Melanogenesis_Homo sapiens_hsa049161.04088772
48Thyroid hormone synthesis_Homo sapiens_hsa049181.02636879
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02518813
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01795458
51Folate biosynthesis_Homo sapiens_hsa007901.01539255
52Nitrogen metabolism_Homo sapiens_hsa009101.00233940
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.99939184
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93708936
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93704914
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92408921
57Dorso-ventral axis formation_Homo sapiens_hsa043200.91992727
58Fatty acid elongation_Homo sapiens_hsa000620.89757519
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86653114
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86475136
61ErbB signaling pathway_Homo sapiens_hsa040120.85217656
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.78191119
63Glucagon signaling pathway_Homo sapiens_hsa049220.78061263
64Cardiac muscle contraction_Homo sapiens_hsa042600.77532193
65Oocyte meiosis_Homo sapiens_hsa041140.75598668
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75482015
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75459300
68Dilated cardiomyopathy_Homo sapiens_hsa054140.73687967
69* Type I diabetes mellitus_Homo sapiens_hsa049400.73455974
70Axon guidance_Homo sapiens_hsa043600.73347788
71beta-Alanine metabolism_Homo sapiens_hsa004100.72351663
72Mineral absorption_Homo sapiens_hsa049780.70848176
73Sphingolipid metabolism_Homo sapiens_hsa006000.69096510
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.65940700
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65378949
76Ether lipid metabolism_Homo sapiens_hsa005650.64853537
77Prion diseases_Homo sapiens_hsa050200.64781639
78MAPK signaling pathway_Homo sapiens_hsa040100.64405050
79ABC transporters_Homo sapiens_hsa020100.64237297
80Alcoholism_Homo sapiens_hsa050340.60777883
81Alzheimers disease_Homo sapiens_hsa050100.60371780
82mTOR signaling pathway_Homo sapiens_hsa041500.60232249
83Choline metabolism in cancer_Homo sapiens_hsa052310.55830235
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.55642795
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54886864
86Selenocompound metabolism_Homo sapiens_hsa004500.54584128
87Fatty acid metabolism_Homo sapiens_hsa012120.53923159
88Phototransduction_Homo sapiens_hsa047440.53259271
89Circadian rhythm_Homo sapiens_hsa047100.52895573
90Bile secretion_Homo sapiens_hsa049760.52726125
91VEGF signaling pathway_Homo sapiens_hsa043700.52388126
92Inositol phosphate metabolism_Homo sapiens_hsa005620.51989536
93Ras signaling pathway_Homo sapiens_hsa040140.51442428
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51032334
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49447414
96Insulin signaling pathway_Homo sapiens_hsa049100.49099015
97Tryptophan metabolism_Homo sapiens_hsa003800.48960393
98Ovarian steroidogenesis_Homo sapiens_hsa049130.48795407
99Endocytosis_Homo sapiens_hsa041440.48355702
100Rap1 signaling pathway_Homo sapiens_hsa040150.46845395
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46311775
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44718401
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43462318
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42803523
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42691914
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.41351304
107Arginine biosynthesis_Homo sapiens_hsa002200.39361949
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38995203
109Peroxisome_Homo sapiens_hsa041460.38597759
110AMPK signaling pathway_Homo sapiens_hsa041520.38417927
111Non-small cell lung cancer_Homo sapiens_hsa052230.37099585
112Prolactin signaling pathway_Homo sapiens_hsa049170.36724447
113Renal cell carcinoma_Homo sapiens_hsa052110.36665241
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36476715
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36233180
116Parkinsons disease_Homo sapiens_hsa050120.35817909
117Lysosome_Homo sapiens_hsa041420.34704826
118Endometrial cancer_Homo sapiens_hsa052130.33649308
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31937991
120Wnt signaling pathway_Homo sapiens_hsa043100.30715200
121Chemokine signaling pathway_Homo sapiens_hsa040620.29634137
122Propanoate metabolism_Homo sapiens_hsa006400.29075688
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27133876
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26771473
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26410140
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.25956412
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25471877
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24745326
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23394860
130Insulin resistance_Homo sapiens_hsa049310.23130135
131Arginine and proline metabolism_Homo sapiens_hsa003300.21798943

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