PTPRN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.67084730
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52950228
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48271257
4COPI coating of Golgi vesicle (GO:0048205)5.13044808
5Golgi transport vesicle coating (GO:0048200)5.13044808
6locomotory exploration behavior (GO:0035641)4.94276480
7regulation of synaptic vesicle exocytosis (GO:2000300)4.60660328
8synaptic vesicle exocytosis (GO:0016079)4.23564898
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.18895481
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12506347
11glutamate secretion (GO:0014047)4.09711830
12regulation of synaptic vesicle transport (GO:1902803)4.03638284
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.01991292
14postsynaptic membrane organization (GO:0001941)4.00102952
15cerebellar Purkinje cell layer development (GO:0021680)3.97861838
16insulin secretion (GO:0030073)3.89116034
17chemosensory behavior (GO:0007635)3.88367343
18activation of protein kinase A activity (GO:0034199)3.86161129
19neurotransmitter-gated ion channel clustering (GO:0072578)3.80376087
20vocalization behavior (GO:0071625)3.80202919
21positive regulation of synapse maturation (GO:0090129)3.75098350
22neurotransmitter secretion (GO:0007269)3.72119482
23positive regulation of neurotransmitter transport (GO:0051590)3.69028787
24detection of calcium ion (GO:0005513)3.66241505
25regulation of neuronal synaptic plasticity (GO:0048168)3.62136825
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.58788094
27regulation of glutamate receptor signaling pathway (GO:1900449)3.56638847
28presynaptic membrane organization (GO:0097090)3.56307306
29glutamate receptor signaling pathway (GO:0007215)3.52478243
30exploration behavior (GO:0035640)3.51931641
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51298620
32presynaptic membrane assembly (GO:0097105)3.49971599
33membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.47930729
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46922390
35cerebellar granule cell differentiation (GO:0021707)3.46223680
36regulation of ARF protein signal transduction (GO:0032012)3.44953834
37layer formation in cerebral cortex (GO:0021819)3.44670721
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44208167
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.43130311
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42818999
41proline transport (GO:0015824)3.42490535
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42408265
43type B pancreatic cell development (GO:0003323)3.41276253
44protein maturation by protein folding (GO:0022417)3.40882312
45regulation of calcium ion-dependent exocytosis (GO:0017158)3.38930404
46positive regulation of neurotransmitter secretion (GO:0001956)3.38242050
47regulation of neurotransmitter levels (GO:0001505)3.36966005
48regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.36870612
49potassium ion homeostasis (GO:0055075)3.36543734
50dendritic spine morphogenesis (GO:0060997)3.31674006
51peptide hormone processing (GO:0016486)3.30702568
52endocrine pancreas development (GO:0031018)3.30148919
53axonal fasciculation (GO:0007413)3.29804638
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28754024
55axon ensheathment in central nervous system (GO:0032291)3.28256420
56central nervous system myelination (GO:0022010)3.28256420
57neuronal action potential propagation (GO:0019227)3.20315144
58positive regulation of dendritic spine development (GO:0060999)3.19838775
59neuron recognition (GO:0008038)3.17164228
60regulation of synapse structural plasticity (GO:0051823)3.16256025
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14358995
62vesicle transport along microtubule (GO:0047496)3.14253694
63regulation of insulin secretion (GO:0050796)3.13854076
64cellular response to glucagon stimulus (GO:0071377)3.13324558
65protein retention in ER lumen (GO:0006621)3.12019684
66cell communication by electrical coupling (GO:0010644)3.11774129
67regulation of postsynaptic membrane potential (GO:0060078)3.11713399
68membrane repolarization during action potential (GO:0086011)3.10577877
69transmission of nerve impulse (GO:0019226)3.10439055
70regulation of neurotransmitter transport (GO:0051588)3.10099369
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09599505
72sodium ion export (GO:0071436)3.09393830
73innervation (GO:0060384)3.09068460
74cellular potassium ion homeostasis (GO:0030007)3.08882884
75synaptic vesicle endocytosis (GO:0048488)3.08857044
76positive regulation of insulin secretion (GO:0032024)3.07906936
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07892794
78activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.07511823
79negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06656400
80pyrimidine nucleobase catabolic process (GO:0006208)3.06360920
81neuron cell-cell adhesion (GO:0007158)3.04323760
82regulation of synapse maturation (GO:0090128)3.03413175
83protein targeting to Golgi (GO:0000042)3.03070709
84glandular epithelial cell development (GO:0002068)3.00883776
85ionotropic glutamate receptor signaling pathway (GO:0035235)3.00682010
86nucleobase catabolic process (GO:0046113)3.00280773
87protein localization to synapse (GO:0035418)2.98777643
88response to dietary excess (GO:0002021)2.98538302
89glycine transport (GO:0015816)2.98483380
90positive regulation of exocytosis (GO:0045921)2.98461929
91membrane hyperpolarization (GO:0060081)2.98289299
92gamma-aminobutyric acid transport (GO:0015812)2.98226458
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97877145
94positive regulation of membrane potential (GO:0045838)2.97803722
95synaptic transmission, glutamatergic (GO:0035249)2.97787263
96suckling behavior (GO:0001967)2.97387239
97peptide hormone secretion (GO:0030072)2.95965445
98long-term memory (GO:0007616)2.95219658
99adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.93562121
100vesicle coating (GO:0006901)2.92307474
101neuromuscular process controlling posture (GO:0050884)2.91811557
102neurotransmitter transport (GO:0006836)2.90459774
103peptide secretion (GO:0002790)2.89089703
104potassium ion import (GO:0010107)2.88169393
105regulation of dendritic spine morphogenesis (GO:0061001)2.88044179
106positive regulation of nuclease activity (GO:0032075)2.87754156
107signal release (GO:0023061)2.87726768
108regulation of exocytosis (GO:0017157)2.86624777
109cellular sodium ion homeostasis (GO:0006883)2.85756307
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85714522
111response to auditory stimulus (GO:0010996)2.85514059
112regulation of peptide hormone secretion (GO:0090276)2.84982209
113neuromuscular process controlling balance (GO:0050885)2.83846272
114regulation of vesicle fusion (GO:0031338)2.83684999
115response to ischemia (GO:0002931)2.83510271
116membrane depolarization (GO:0051899)2.83443058
117regulation of peptide secretion (GO:0002791)2.83232069
118inner ear receptor cell development (GO:0060119)2.82080033
119membrane repolarization (GO:0086009)2.81247186
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.81054668
121neuronal ion channel clustering (GO:0045161)2.80011355
122L-amino acid import (GO:0043092)2.78075541
123establishment of protein localization to Golgi (GO:0072600)2.77785903
124neuromuscular synaptic transmission (GO:0007274)2.76502770
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75755451
126nerve growth factor signaling pathway (GO:0038180)2.74182276
127negative regulation of dendrite morphogenesis (GO:0050774)2.73709630
128regulation of neurotransmitter secretion (GO:0046928)2.73507191
129cell migration in hindbrain (GO:0021535)2.73241260
130regulation of synaptic plasticity (GO:0048167)2.72985651
131positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72638519
132synapse assembly (GO:0007416)2.71242777
133negative regulation of catecholamine secretion (GO:0033604)2.70840537
134neuron-neuron synaptic transmission (GO:0007270)2.70806482
135nitric oxide mediated signal transduction (GO:0007263)2.69966096
136synaptic transmission (GO:0007268)2.69649496
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.68892864
138regulation of type B pancreatic cell apoptotic process (GO:2000674)2.68367479
139regulation of dendritic spine development (GO:0060998)2.68323201
140positive regulation of potassium ion transport (GO:0043268)2.67722863
141startle response (GO:0001964)2.67644683
142auditory behavior (GO:0031223)2.67516070
143cerebellar Purkinje cell differentiation (GO:0021702)2.66642500
144organelle transport along microtubule (GO:0072384)2.66353189
145dendritic spine organization (GO:0097061)2.66222791
146membrane depolarization during action potential (GO:0086010)2.66054585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05334305
2* REST_21632747_ChIP-Seq_MESCs_Mouse2.92894359
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79308295
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.69884401
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69772936
6GBX2_23144817_ChIP-Seq_PC3_Human2.61891463
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60124390
8DROSHA_22980978_ChIP-Seq_HELA_Human2.58651766
9* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48761926
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42264111
11* REST_18959480_ChIP-ChIP_MESCs_Mouse2.40914030
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34295536
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28431951
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26403075
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17248995
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17248995
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12116301
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.11784996
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10119755
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05915530
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.05863826
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03552945
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99988915
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99327184
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.97309183
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81818072
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.81124478
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79489072
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.74831903
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68029867
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66512717
32ZNF274_21170338_ChIP-Seq_K562_Hela1.65219637
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58799491
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58012780
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53465657
36GATA1_22025678_ChIP-Seq_K562_Human1.52705707
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51759850
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46338021
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46121701
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.45397485
41RNF2_27304074_Chip-Seq_NSC_Mouse1.41679775
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.40820776
43KDM2B_26808549_Chip-Seq_K562_Human1.40740240
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37895480
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35751349
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33926702
47* AR_19668381_ChIP-Seq_PC3_Human1.32484183
48* STAT3_23295773_ChIP-Seq_U87_Human1.32342150
49* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30158172
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28509782
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26295673
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25378143
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25078685
54TAF15_26573619_Chip-Seq_HEK293_Human1.22458626
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22265177
56* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20751913
57* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20346570
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19981456
59YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19030992
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17503913
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16264836
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15764116
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14713241
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13319532
65* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13147651
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12387529
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.10999961
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10863343
69* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10738779
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09967996
71* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09809512
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.08168647
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07403929
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.06005881
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04513539
76* TCF4_23295773_ChIP-Seq_U87_Human1.03382658
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03007941
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02784025
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.02065927
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.01498475
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01465088
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99634775
83P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98694469
84AR_21572438_ChIP-Seq_LNCaP_Human0.98082426
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.97628944
86* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96789946
87* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96789946
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96110623
89* AR_25329375_ChIP-Seq_VCAP_Human0.95582491
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94976104
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94319090
92RING1B_27294783_Chip-Seq_NPCs_Mouse0.93421104
93ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92972555
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92562031
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92412945
96CTCF_27219007_Chip-Seq_Bcells_Human0.92388977
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91780162
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89798809
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.89686989
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89145483
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88457442
102P300_19829295_ChIP-Seq_ESCs_Human0.88448532
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.87873786
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86130010
105* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85552840
106* ARNT_22903824_ChIP-Seq_MCF-7_Human0.85426347
107* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84577289
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83939612
109KLF4_19829295_ChIP-Seq_ESCs_Human0.83721205
110* AHR_22903824_ChIP-Seq_MCF-7_Human0.83317637
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82898668
112RXR_22108803_ChIP-Seq_LS180_Human0.82682490
113GATA1_19941826_ChIP-Seq_K562_Human0.82527565
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.82110100
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81591943
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80143697
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79954742
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79738195
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79730628
120CREB1_26743006_Chip-Seq_LNCaP_Human0.79654314
121* IGF1R_20145208_ChIP-Seq_DFB_Human0.79288180
122* RUNX2_22187159_ChIP-Seq_PCA_Human0.79143053
123BCAT_22108803_ChIP-Seq_LS180_Human0.77826292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06293619
2MP0002909_abnormal_adrenal_gland4.05841785
3MP0003283_abnormal_digestive_organ3.92966284
4MP0009780_abnormal_chondrocyte_physiolo3.80389589
5MP0004270_analgesia3.66167228
6MP0003635_abnormal_synaptic_transmissio3.25253693
7MP0002877_abnormal_melanocyte_morpholog2.75944944
8MP0000013_abnormal_adipose_tissue2.59113538
9MP0002693_abnormal_pancreas_physiology2.58737331
10MP0003880_abnormal_central_pattern2.52234211
11MP0002063_abnormal_learning/memory/cond2.51234898
12MP0004043_abnormal_pH_regulation2.36132047
13MP0009745_abnormal_behavioral_response2.35393462
14MP0001944_abnormal_pancreas_morphology2.27938015
15MP0002734_abnormal_mechanical_nocicepti2.22474331
16MP0002064_seizures2.21760432
17MP0005646_abnormal_pituitary_gland2.12794768
18MP0002572_abnormal_emotion/affect_behav2.11800422
19MP0002822_catalepsy1.97779829
20MP0003122_maternal_imprinting1.97673193
21MP0005645_abnormal_hypothalamus_physiol1.97617844
22MP0010386_abnormal_urinary_bladder1.92438770
23MP0009046_muscle_twitch1.90742052
24MP0002272_abnormal_nervous_system1.88716727
25MP0003195_calcinosis1.87429559
26MP0008961_abnormal_basal_metabolism1.83872218
27MP0000678_abnormal_parathyroid_gland1.81184904
28MP0002733_abnormal_thermal_nociception1.79746313
29MP0005423_abnormal_somatic_nervous1.78359272
30MP0003787_abnormal_imprinting1.75546385
31MP0005379_endocrine/exocrine_gland_phen1.75541068
32MP0003183_abnormal_peptide_metabolism1.74510677
33MP0001486_abnormal_startle_reflex1.70760787
34MP0004858_abnormal_nervous_system1.68412036
35MP0001501_abnormal_sleep_pattern1.67574507
36MP0001968_abnormal_touch/_nociception1.60372872
37MP0001970_abnormal_pain_threshold1.59843731
38MP0002234_abnormal_pharynx_morphology1.58611763
39MP0003172_abnormal_lysosome_physiology1.53324204
40MP0004811_abnormal_neuron_physiology1.52932996
41MP0003121_genomic_imprinting1.52835731
42MP0003879_abnormal_hair_cell1.50154999
43MP0008569_lethality_at_weaning1.48608685
44MP0003329_amyloid_beta_deposits1.47424510
45* MP0002078_abnormal_glucose_homeostasis1.45401167
46MP0000955_abnormal_spinal_cord1.43015111
47MP0002557_abnormal_social/conspecific_i1.40345889
48MP0001905_abnormal_dopamine_level1.39513482
49MP0000003_abnormal_adipose_tissue1.31846247
50MP0005386_behavior/neurological_phenoty1.28726555
51MP0004924_abnormal_behavior1.28726555
52MP0002638_abnormal_pupillary_reflex1.27923523
53MP0008877_abnormal_DNA_methylation1.26594765
54MP0002067_abnormal_sensory_capabilities1.25534534
55MP0002184_abnormal_innervation1.24746005
56MP0001440_abnormal_grooming_behavior1.22956254
57MP0002735_abnormal_chemical_nociception1.22155851
58MP0003633_abnormal_nervous_system1.22003114
59MP0005551_abnormal_eye_electrophysiolog1.21595890
60MP0002837_dystrophic_cardiac_calcinosis1.21100172
61MP0004145_abnormal_muscle_electrophysio1.17861316
62MP0005535_abnormal_body_temperature1.17172053
63MP0004742_abnormal_vestibular_system1.15271085
64MP0002653_abnormal_ependyma_morphology1.13572781
65MP0001502_abnormal_circadian_rhythm1.13518831
66MP0004885_abnormal_endolymph1.10981611
67MP0000631_abnormal_neuroendocrine_gland1.10786885
68MP0003690_abnormal_glial_cell1.10584032
69MP0001986_abnormal_taste_sensitivity1.09776208
70MP0000566_synostosis1.09128131
71MP0001765_abnormal_ion_homeostasis1.09093603
72MP0002066_abnormal_motor_capabilities/c1.08043421
73MP0002882_abnormal_neuron_morphology1.07533631
74MP0004133_heterotaxia1.06379468
75MP0003953_abnormal_hormone_level1.05415343
76MP0001485_abnormal_pinna_reflex1.05278101
77MP0004142_abnormal_muscle_tone1.03958207
78MP0006072_abnormal_retinal_apoptosis1.03457487
79MP0005187_abnormal_penis_morphology1.01562781
80MP0001188_hyperpigmentation1.00793484
81MP0002069_abnormal_eating/drinking_beha1.00467105
82MP0001984_abnormal_olfaction0.99928223
83MP0003045_fibrosis0.99050773
84MP0005220_abnormal_exocrine_pancreas0.98157628
85MP0002896_abnormal_bone_mineralization0.97977589
86MP0010234_abnormal_vibrissa_follicle0.95661758
87MP0000778_abnormal_nervous_system0.93912215
88MP0001299_abnormal_eye_distance/0.92827059
89MP0001963_abnormal_hearing_physiology0.92607358
90MP0002736_abnormal_nociception_after0.90698869
91MP0002229_neurodegeneration0.89701940
92MP0000920_abnormal_myelination0.86170871
93MP0006276_abnormal_autonomic_nervous0.85979766
94MP0003631_nervous_system_phenotype0.84190265
95MP0004085_abnormal_heartbeat0.83332969
96MP0003632_abnormal_nervous_system0.81634953
97MP0004264_abnormal_extraembryonic_tissu0.81573453
98MP0003634_abnormal_glial_cell0.81490879
99MP0003075_altered_response_to0.79757819
100MP0003300_gastrointestinal_ulcer0.78475756
101MP0010329_abnormal_lipoprotein_level0.77336230
102MP0002152_abnormal_brain_morphology0.77076024
103MP0002752_abnormal_somatic_nervous0.76672135
104MP0005448_abnormal_energy_balance0.76323311
105MP0006292_abnormal_olfactory_placode0.76295047
106MP0003123_paternal_imprinting0.76179238
107MP0000569_abnormal_digit_pigmentation0.75928331
108MP0003868_abnormal_feces_composition0.75840733
109MP0000462_abnormal_digestive_system0.74604670
110MP0003119_abnormal_digestive_system0.72948826
111MP0005394_taste/olfaction_phenotype0.72354254
112MP0005499_abnormal_olfactory_system0.72354254
113MP0002928_abnormal_bile_duct0.71592280
114MP0003938_abnormal_ear_development0.71028884
115MP0000026_abnormal_inner_ear0.70351898
116MP0003959_abnormal_lean_body0.68589035
117MP0008872_abnormal_physiological_respon0.67459902
118MP0001664_abnormal_digestion0.67171528
119MP0000639_abnormal_adrenal_gland0.66255730
120MP0002876_abnormal_thyroid_physiology0.63684885
121MP0005253_abnormal_eye_physiology0.63009316
122MP0002163_abnormal_gland_morphology0.61778667
123MP0000230_abnormal_systemic_arterial0.61544677
124MP0008875_abnormal_xenobiotic_pharmacok0.60610879
125MP0001529_abnormal_vocalization0.60458979
126MP0001756_abnormal_urination0.59550603
127MP0004233_abnormal_muscle_weight0.58932545

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.15165063
2Hyperinsulinemic hypoglycemia (HP:0000825)5.46369847
3Hypoglycemic seizures (HP:0002173)4.61863831
4Visual hallucinations (HP:0002367)4.54073372
5Papilledema (HP:0001085)4.45997702
6Focal motor seizures (HP:0011153)4.32456913
7Symptomatic seizures (HP:0011145)4.05503325
8Myokymia (HP:0002411)4.02417224
9Limb dystonia (HP:0002451)3.92240578
10Abnormality of calcium-phosphate metabolism (HP:0100530)3.70249653
11Insulin-resistant diabetes mellitus (HP:0000831)3.65938344
12Abnormality of the pancreatic islet cells (HP:0006476)3.55968280
13Abnormality of endocrine pancreas physiology (HP:0012093)3.55968280
14Pancreatic islet-cell hyperplasia (HP:0004510)3.54978015
15Focal seizures (HP:0007359)3.47289576
16Agitation (HP:0000713)3.44884334
17Hyperglycemia (HP:0003074)3.34507560
18Large for gestational age (HP:0001520)3.34137466
19Hypoglycemic coma (HP:0001325)3.30967685
20Ketoacidosis (HP:0001993)3.20883102
21EEG with generalized epileptiform discharges (HP:0011198)3.15617492
22Abnormality of binocular vision (HP:0011514)3.13874886
23Diplopia (HP:0000651)3.13874886
24Hypsarrhythmia (HP:0002521)3.12455606
25Polyphagia (HP:0002591)3.12170133
26Epileptiform EEG discharges (HP:0011182)3.11032635
27Depression (HP:0000716)3.04910972
28Amblyopia (HP:0000646)2.98305121
29Supranuclear gaze palsy (HP:0000605)2.97487842
30Action tremor (HP:0002345)2.92577406
31Decreased circulating renin level (HP:0003351)2.88018967
32Epileptic encephalopathy (HP:0200134)2.85532730
33Atonic seizures (HP:0010819)2.84879673
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82158484
35Abnormal respiratory motile cilium morphology (HP:0005938)2.80716455
36Abnormal respiratory epithelium morphology (HP:0012253)2.80716455
37Absence seizures (HP:0002121)2.80075158
38Ankle clonus (HP:0011448)2.78527114
39Abnormal ciliary motility (HP:0012262)2.73270713
40Focal dystonia (HP:0004373)2.70675705
41Akinesia (HP:0002304)2.69605131
42Generalized tonic-clonic seizures (HP:0002069)2.67229540
43Anxiety (HP:0000739)2.62302190
44Ventricular fibrillation (HP:0001663)2.61733020
45Late onset (HP:0003584)2.61336451
46Abnormal respiratory motile cilium physiology (HP:0012261)2.60776028
47Increased circulating renin level (HP:0000848)2.60365723
48Status epilepticus (HP:0002133)2.58205868
49Progressive cerebellar ataxia (HP:0002073)2.57622809
50Pheochromocytoma (HP:0002666)2.55631927
51Hyperparathyroidism (HP:0000843)2.53575355
52Impaired smooth pursuit (HP:0007772)2.52963300
53Hypercortisolism (HP:0001578)2.51748377
54Hyperventilation (HP:0002883)2.51530077
55Congenital malformation of the right heart (HP:0011723)2.51091426
56Double outlet right ventricle (HP:0001719)2.51091426
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.49392346
58Absent/shortened dynein arms (HP:0200106)2.49392346
59Sleep apnea (HP:0010535)2.49345581
60Abnormality of the corticospinal tract (HP:0002492)2.48801704
61Gait imbalance (HP:0002141)2.47850720
62Dialeptic seizures (HP:0011146)2.47432409
63Macroorchidism (HP:0000053)2.45744591
64Urinary glycosaminoglycan excretion (HP:0003541)2.44848632
65Mucopolysacchariduria (HP:0008155)2.44848632
66Truncal ataxia (HP:0002078)2.44241339
67Retinal atrophy (HP:0001105)2.42637452
68Abnormal pancreas size (HP:0012094)2.38323014
69Rhinitis (HP:0012384)2.38008274
70Craniofacial dystonia (HP:0012179)2.37391687
71Broad-based gait (HP:0002136)2.36682981
72Menstrual irregularities (HP:0000858)2.33673767
73Abnormality of polysaccharide metabolism (HP:0011012)2.31772030
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31772030
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31772030
76Poor eye contact (HP:0000817)2.31386866
77Hypokalemia (HP:0002900)2.30621153
78Postural instability (HP:0002172)2.27469628
79Bundle branch block (HP:0011710)2.27035252
80Fetal akinesia sequence (HP:0001989)2.26434191
81Insomnia (HP:0100785)2.26112143
82Abnormality of renin-angiotensin system (HP:0000847)2.24464340
83Abnormal social behavior (HP:0012433)2.22279641
84Impaired social interactions (HP:0000735)2.22279641
85Febrile seizures (HP:0002373)2.21842650
86Megalencephaly (HP:0001355)2.21548551
87Cerebral inclusion bodies (HP:0100314)2.20567470
88Failure to thrive in infancy (HP:0001531)2.19709846
89Dysostosis multiplex (HP:0000943)2.18809445
90Impaired vibration sensation in the lower limbs (HP:0002166)2.17276069
91Neurofibrillary tangles (HP:0002185)2.16977672
92Mutism (HP:0002300)2.13993613
93Hemiparesis (HP:0001269)2.13700237
94Hyperthyroidism (HP:0000836)2.13649753
95Obstructive sleep apnea (HP:0002870)2.11745366
96Unilateral renal agenesis (HP:0000122)2.09093114
97Neuroendocrine neoplasm (HP:0100634)2.08279675
98Resting tremor (HP:0002322)2.07574444
99Prominent metopic ridge (HP:0005487)2.06527702
100Enlarged penis (HP:0000040)2.05112327
101Ankyloglossia (HP:0010296)2.04294283
102Urinary bladder sphincter dysfunction (HP:0002839)2.00469388
103Restlessness (HP:0000711)2.00023669
104Excessive salivation (HP:0003781)1.98169203
105Drooling (HP:0002307)1.98169203
106Abnormality of ocular smooth pursuit (HP:0000617)1.97768691
107Spastic gait (HP:0002064)1.97144358
108Neoplasm of the heart (HP:0100544)1.96819478
109Nephronophthisis (HP:0000090)1.96672016
110Spastic tetraplegia (HP:0002510)1.96418651
111Urinary urgency (HP:0000012)1.95811815
112Dysdiadochokinesis (HP:0002075)1.94851408
113Gaze-evoked nystagmus (HP:0000640)1.94527438
114Hyperphosphatemia (HP:0002905)1.94500127
115Abnormality of potassium homeostasis (HP:0011042)1.94162412
116Genetic anticipation (HP:0003743)1.94108210
117Medial flaring of the eyebrow (HP:0010747)1.93020703
118Dysmetria (HP:0001310)1.91469971
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91439737
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.91439737
121Postural tremor (HP:0002174)1.90302166
122Bradykinesia (HP:0002067)1.88598136
123Clonus (HP:0002169)1.87485036
124Absent speech (HP:0001344)1.86519713
125Prolonged QT interval (HP:0001657)1.86402414
126Cortical visual impairment (HP:0100704)1.85458556
127Intention tremor (HP:0002080)1.84432082
128Abnormality of the metopic suture (HP:0005556)1.82863859
129Hemiplegia (HP:0002301)1.82084356
130Congenital glaucoma (HP:0001087)1.81400518
131Abnormal eating behavior (HP:0100738)1.80630922
132Abnormality of the lower motor neuron (HP:0002366)1.80526653
133Poor suck (HP:0002033)1.78935640
134Congenital primary aphakia (HP:0007707)1.78633880
135Muscular hypotonia of the trunk (HP:0008936)1.78126796
136Abnormal EKG (HP:0003115)1.77348262
137Insulin resistance (HP:0000855)1.77238194
138Adrenal overactivity (HP:0002717)1.76801070
139Hepatoblastoma (HP:0002884)1.76188193
140Morphological abnormality of the pyramidal tract (HP:0002062)1.76109423
141Hypomagnesemia (HP:0002917)1.74132588
142Specific learning disability (HP:0001328)1.74060844
143Torticollis (HP:0000473)1.73672822
144Impaired vibratory sensation (HP:0002495)1.72516665
145Spastic tetraparesis (HP:0001285)1.71406901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.36087748
2INSRR3.93785630
3PRKD33.79509788
4CASK3.44176451
5MAP3K93.08187629
6EPHA42.64243124
7MAP3K22.58424548
8NTRK12.51022484
9PASK2.40600675
10TAOK32.37285790
11MARK12.34737877
12MAP3K42.12549579
13UHMK12.11941040
14KSR22.07330512
15CAMKK12.02650415
16DAPK22.01748361
17MINK11.92232956
18PAK61.91767247
19HIPK21.86770695
20SCYL21.84583258
21MAP3K11.84158192
22WNK31.77200053
23CAMKK21.73206478
24MAPK151.71604318
25PRKCH1.69655525
26FGFR21.60474863
27NTRK21.55206290
28CDK51.39163671
29MAP2K71.37601174
30FRK1.37381253
31PDGFRA1.24597060
32CDC42BPA1.22950805
33RET1.17908943
34MAP2K41.16151903
35ALK1.14490990
36PAK31.09832274
37DYRK21.09665274
38CDK191.07099430
39GRK51.05731435
40WNK41.04617145
41DAPK11.03877499
42TAOK11.02829656
43STK381.02600594
44KSR11.01941248
45MAP2K61.00305574
46FGFR30.97719963
47TRIB30.97652822
48PRKCG0.94169983
49MARK20.85946240
50EPHA30.85581710
51SGK2230.83474996
52SGK4940.83474996
53STK110.83281235
54RIPK10.82691909
55FES0.81858070
56PRKD20.81339330
57BRSK10.81251253
58RIPK40.81027036
59SGK30.77960348
60WNK10.77152003
61PRKCZ0.75319543
62OXSR10.75257743
63SGK20.71677030
64MAPK130.70979867
65TYRO30.68705526
66PTK20.68336009
67CAMK10.65127661
68TNIK0.65003598
69CAMK2B0.64785815
70CAMK2A0.64406653
71CAMK1G0.63636527
72PNCK0.63024325
73FER0.62477386
74TNK20.61012385
75CAMK40.60610461
76SGK10.58833080
77PKN10.57679641
78PDPK10.57648554
79PDK10.57507520
80LMTK20.56192241
81ERBB20.56015454
82RPS6KA30.55842235
83PHKG20.55183269
84PHKG10.55183269
85CAMK2D0.55160102
86SIK20.53837623
87MAP4K20.52339367
88PRKAA10.50646833
89DYRK1A0.50521734
90PRKCE0.50506520
91PTK60.49927557
92CSNK1G20.49860559
93RPS6KA20.49829299
94NEK60.48930653
95ARAF0.47621053
96CAMK2G0.47538892
97JAK20.47448077
98PRKG10.46945994
99AKT30.46473555
100LIMK10.45088578
101STK390.44931300
102CDK140.44786026
103MAPK100.44269906
104BCR0.43541958
105PINK10.43517707
106PRKACA0.43347244
107PRKD10.42599363
108CDK150.42033521
109LATS20.41785352
110ERN10.41680136
111CDK180.41611668
112MAP2K10.41316408
113PRPF4B0.41041726
114PRKACG0.40404430
115GRK10.39291230
116DYRK1B0.38347394
117MAP3K130.38333555
118CSNK1E0.37791066
119MAP3K120.37424011
120CAMK1D0.37122153
121PRKCA0.36482519
122FYN0.36364711
123PDGFRB0.36286930
124CSNK1G30.36091560
125PLK20.33911853
126PRKCB0.33468005
127CDK11A0.32243086

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.36319944
2Insulin secretion_Homo sapiens_hsa049113.27751914
3Synaptic vesicle cycle_Homo sapiens_hsa047212.55848518
4Type II diabetes mellitus_Homo sapiens_hsa049302.54099084
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39948751
6Amphetamine addiction_Homo sapiens_hsa050312.26930742
7Circadian entrainment_Homo sapiens_hsa047132.25443876
8GABAergic synapse_Homo sapiens_hsa047272.25428240
9Long-term potentiation_Homo sapiens_hsa047202.22356780
10Nicotine addiction_Homo sapiens_hsa050332.06613858
11Olfactory transduction_Homo sapiens_hsa047401.98134367
12Cocaine addiction_Homo sapiens_hsa050301.97501142
13Glutamatergic synapse_Homo sapiens_hsa047241.93049032
14Morphine addiction_Homo sapiens_hsa050321.92971127
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92332084
16Dopaminergic synapse_Homo sapiens_hsa047281.91742853
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87171196
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82165271
19Cholinergic synapse_Homo sapiens_hsa047251.80228692
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75338437
21Taste transduction_Homo sapiens_hsa047421.64524642
22Salivary secretion_Homo sapiens_hsa049701.61546438
23Gastric acid secretion_Homo sapiens_hsa049711.60118308
24Pancreatic secretion_Homo sapiens_hsa049721.57421450
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55678129
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46733502
27Renin secretion_Homo sapiens_hsa049241.43824425
28Butanoate metabolism_Homo sapiens_hsa006501.37948811
29Serotonergic synapse_Homo sapiens_hsa047261.35875367
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31899128
31Vibrio cholerae infection_Homo sapiens_hsa051101.29605151
32Estrogen signaling pathway_Homo sapiens_hsa049151.29583734
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28658072
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22257339
35Nitrogen metabolism_Homo sapiens_hsa009101.21663760
36Vitamin B6 metabolism_Homo sapiens_hsa007501.21557055
37GnRH signaling pathway_Homo sapiens_hsa049121.20941542
38Cardiac muscle contraction_Homo sapiens_hsa042601.20347086
39Long-term depression_Homo sapiens_hsa047301.20017672
40Phototransduction_Homo sapiens_hsa047441.18871193
41Oxytocin signaling pathway_Homo sapiens_hsa049211.18396605
42Gap junction_Homo sapiens_hsa045401.16880738
43Thyroid hormone synthesis_Homo sapiens_hsa049181.14868480
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14680635
45cAMP signaling pathway_Homo sapiens_hsa040241.12996037
46Calcium signaling pathway_Homo sapiens_hsa040201.10786036
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07449900
48* Type I diabetes mellitus_Homo sapiens_hsa049401.01571509
49Glucagon signaling pathway_Homo sapiens_hsa049220.98967411
50Dorso-ventral axis formation_Homo sapiens_hsa043200.96681768
51Glioma_Homo sapiens_hsa052140.95511851
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.95488920
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94691056
54Protein export_Homo sapiens_hsa030600.94036371
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92512461
56Melanogenesis_Homo sapiens_hsa049160.91387179
57Collecting duct acid secretion_Homo sapiens_hsa049660.87318323
58mTOR signaling pathway_Homo sapiens_hsa041500.87062426
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83441030
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81753417
61Sulfur metabolism_Homo sapiens_hsa009200.81741079
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81544594
63Circadian rhythm_Homo sapiens_hsa047100.78107056
64Prion diseases_Homo sapiens_hsa050200.74624583
65ErbB signaling pathway_Homo sapiens_hsa040120.74602638
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.70940934
67Histidine metabolism_Homo sapiens_hsa003400.70910210
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68914294
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68659000
70beta-Alanine metabolism_Homo sapiens_hsa004100.67516007
71Prolactin signaling pathway_Homo sapiens_hsa049170.66825602
72N-Glycan biosynthesis_Homo sapiens_hsa005100.66309933
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65666732
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.65013340
75Insulin signaling pathway_Homo sapiens_hsa049100.64376092
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63779969
77Lysosome_Homo sapiens_hsa041420.63764480
78Insulin resistance_Homo sapiens_hsa049310.62678947
79Inositol phosphate metabolism_Homo sapiens_hsa005620.62328704
80Regulation of autophagy_Homo sapiens_hsa041400.61223299
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60164453
82Alcoholism_Homo sapiens_hsa050340.58985622
83Dilated cardiomyopathy_Homo sapiens_hsa054140.58229510
84Oocyte meiosis_Homo sapiens_hsa041140.55792654
85Endometrial cancer_Homo sapiens_hsa052130.55549144
86Mineral absorption_Homo sapiens_hsa049780.54853989
87Bile secretion_Homo sapiens_hsa049760.54405041
88MAPK signaling pathway_Homo sapiens_hsa040100.52871980
89Fatty acid biosynthesis_Homo sapiens_hsa000610.51256330
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.50558839
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50192872
92Axon guidance_Homo sapiens_hsa043600.50058656
93Oxidative phosphorylation_Homo sapiens_hsa001900.49654247
94Arginine biosynthesis_Homo sapiens_hsa002200.48973590
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48627902
96Alzheimers disease_Homo sapiens_hsa050100.47959982
97Endocytosis_Homo sapiens_hsa041440.47933559
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47474257
99VEGF signaling pathway_Homo sapiens_hsa043700.45537639
100Ovarian steroidogenesis_Homo sapiens_hsa049130.44557893
101Choline metabolism in cancer_Homo sapiens_hsa052310.44501926
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43840904
103Renal cell carcinoma_Homo sapiens_hsa052110.43174431
104Folate biosynthesis_Homo sapiens_hsa007900.43044746
105Ras signaling pathway_Homo sapiens_hsa040140.42864251
106Ether lipid metabolism_Homo sapiens_hsa005650.42176574
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41909411
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41906208
109Fatty acid metabolism_Homo sapiens_hsa012120.39570384
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39330188
111Non-small cell lung cancer_Homo sapiens_hsa052230.36983030
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35248188
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.33644862
114Rap1 signaling pathway_Homo sapiens_hsa040150.33602164
115Protein digestion and absorption_Homo sapiens_hsa049740.32909217
116Tight junction_Homo sapiens_hsa045300.32071479
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31797805
118ABC transporters_Homo sapiens_hsa020100.30554715
119Chemokine signaling pathway_Homo sapiens_hsa040620.30441039
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.30120133
121Phenylalanine metabolism_Homo sapiens_hsa003600.29894694
122AMPK signaling pathway_Homo sapiens_hsa041520.29262619
123Arginine and proline metabolism_Homo sapiens_hsa003300.28251408
124Sphingolipid metabolism_Homo sapiens_hsa006000.27711747

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