PTPRO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular epithelial cell development (GO:0072310)8.86472927
2glomerular basement membrane development (GO:0032836)7.02085503
3neuron cell-cell adhesion (GO:0007158)4.47852237
4sequestering of actin monomers (GO:0042989)4.35764725
5retinal ganglion cell axon guidance (GO:0031290)4.32983778
6neuron recognition (GO:0008038)4.27949000
7behavioral response to nicotine (GO:0035095)4.25407716
8limb bud formation (GO:0060174)4.21410498
9establishment of mitochondrion localization (GO:0051654)4.16873400
10positive regulation of dendritic spine morphogenesis (GO:0061003)4.08930963
11vocalization behavior (GO:0071625)4.05913840
12ionotropic glutamate receptor signaling pathway (GO:0035235)3.99683651
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92476656
14locomotory exploration behavior (GO:0035641)3.89980409
15axonal fasciculation (GO:0007413)3.87914469
16regulation of axon extension involved in axon guidance (GO:0048841)3.79089937
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.79020903
18dopaminergic neuron differentiation (GO:0071542)3.76871010
19synaptic vesicle maturation (GO:0016188)3.71793767
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63189106
21pyrimidine nucleobase catabolic process (GO:0006208)3.62416392
22* glomerulus development (GO:0032835)3.61814819
23* regulation of axon guidance (GO:1902667)3.57532063
24establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.55149134
25mitochondrion transport along microtubule (GO:0047497)3.55149134
26* epithelial cell differentiation involved in kidney development (GO:0035850)3.46785120
27regulation of glutamate receptor signaling pathway (GO:1900449)3.46777325
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42589265
29dendrite morphogenesis (GO:0048813)3.41989664
30central nervous system neuron axonogenesis (GO:0021955)3.40228153
31protein localization to synapse (GO:0035418)3.39777988
32mechanosensory behavior (GO:0007638)3.31085937
33exploration behavior (GO:0035640)3.29535838
34glutamate receptor signaling pathway (GO:0007215)3.29408217
35hindbrain development (GO:0030902)3.29168755
36adult walking behavior (GO:0007628)3.27891782
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.27465750
38epithelial cilium movement (GO:0003351)3.23869312
39dendritic spine morphogenesis (GO:0060997)3.23359405
40synaptic transmission, glutamatergic (GO:0035249)3.20773436
41negative regulation of axon extension involved in axon guidance (GO:0048843)3.20656593
42startle response (GO:0001964)3.19597208
43nucleobase catabolic process (GO:0046113)3.14193347
44postsynaptic membrane organization (GO:0001941)3.12293202
45protein localization to cilium (GO:0061512)3.10751184
46neuron remodeling (GO:0016322)3.10149037
47positive regulation of gastrulation (GO:2000543)3.09566303
48synaptic vesicle exocytosis (GO:0016079)3.05236385
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04969027
50heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.03830557
51ganglion development (GO:0061548)3.02546575
52negative regulation of dendrite development (GO:2000171)3.02064423
53layer formation in cerebral cortex (GO:0021819)2.99954348
54response to auditory stimulus (GO:0010996)2.98972365
55neural tube formation (GO:0001841)2.97584904
56neuron fate determination (GO:0048664)2.97499784
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96790461
58glycosphingolipid biosynthetic process (GO:0006688)2.95717377
59neurofilament cytoskeleton organization (GO:0060052)2.94470154
60* negative regulation of axon guidance (GO:1902668)2.92007328
61* negative regulation of axonogenesis (GO:0050771)2.91633230
62axon extension (GO:0048675)2.91516316
63neuron migration (GO:0001764)2.91420463
64auditory behavior (GO:0031223)2.91004116
65regulation of synaptic vesicle exocytosis (GO:2000300)2.89989552
66regulation of synapse structural plasticity (GO:0051823)2.89747576
67somite development (GO:0061053)2.89204578
68short-term memory (GO:0007614)2.89142243
69axonogenesis (GO:0007409)2.87144471
70regulation of extent of cell growth (GO:0061387)2.86831742
71neurotransmitter-gated ion channel clustering (GO:0072578)2.86714289
72neuronal action potential (GO:0019228)2.86353377
73positive regulation of oligodendrocyte differentiation (GO:0048714)2.84597724
74clathrin coat assembly (GO:0048268)2.82114802
75regulation of dendritic spine morphogenesis (GO:0061001)2.81275988
76behavioral response to ethanol (GO:0048149)2.80470042
77spinal cord development (GO:0021510)2.79638461
78synaptic vesicle endocytosis (GO:0048488)2.77650283
79calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.77602083
80neuronal action potential propagation (GO:0019227)2.77482817
81neuron-neuron synaptic transmission (GO:0007270)2.77464757
82hippocampus development (GO:0021766)2.77138718
83olfactory bulb development (GO:0021772)2.76436716
84positive regulation of axon extension (GO:0045773)2.74831516
85positive regulation of dendritic spine development (GO:0060999)2.74637966
86cilium movement (GO:0003341)2.74051553
87positive regulation of amino acid transport (GO:0051957)2.73780075
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72597887
89regulation of collateral sprouting (GO:0048670)2.71621599
90auditory receptor cell stereocilium organization (GO:0060088)2.69703934
91presynaptic membrane assembly (GO:0097105)2.69328743
92regulation of synaptic vesicle transport (GO:1902803)2.63621828
93negative regulation of axon extension (GO:0030517)2.63009813
94axon extension involved in axon guidance (GO:0048846)2.62150744
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.62150744
96proline transport (GO:0015824)2.61315597
97microglial cell activation (GO:0001774)2.58681180
98activated T cell proliferation (GO:0050798)2.58582399
99negative regulation of homotypic cell-cell adhesion (GO:0034111)2.58182557
100dendrite development (GO:0016358)2.57213723
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55079699
102glutamate secretion (GO:0014047)2.54841556
103central nervous system projection neuron axonogenesis (GO:0021952)2.53289339
104regulation of platelet aggregation (GO:0090330)2.53152716
105transmission of nerve impulse (GO:0019226)2.51909781
106neuron projection extension (GO:1990138)2.48166149
107G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.48007977
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.47565631
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47207806
110synapse assembly (GO:0007416)2.46077869
111mating behavior (GO:0007617)2.45547430
112regulation of neuronal synaptic plasticity (GO:0048168)2.44733107
113positive regulation of synapse assembly (GO:0051965)2.43938894
114cell migration in hindbrain (GO:0021535)2.41516679
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.40935027
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40704702
117neurotransmitter secretion (GO:0007269)2.40023013
118synapse organization (GO:0050808)2.39817954
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.39642743
120regulation of axon extension (GO:0030516)2.38455764
121semaphorin-plexin signaling pathway (GO:0071526)2.37068706
122presynaptic membrane organization (GO:0097090)2.36644543
123opioid receptor signaling pathway (GO:0038003)2.36473265
124neuromuscular process controlling balance (GO:0050885)2.32667276
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.32617774
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.31224296
127sialylation (GO:0097503)2.29922097
128positive regulation of cell adhesion mediated by integrin (GO:0033630)2.29272365
129regulation of synapse assembly (GO:0051963)2.29232527
130righting reflex (GO:0060013)2.27650401
131positive regulation by symbiont of host defense response (GO:0052509)2.27190160
132modulation by symbiont of host defense response (GO:0052031)2.27190160
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.27190160
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.27190160
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.27190160
136modulation by symbiont of host immune response (GO:0052553)2.27190160
137regulation of postsynaptic membrane potential (GO:0060078)2.24667057
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.23835488
139neuronal ion channel clustering (GO:0045161)2.23783618
140nerve growth factor signaling pathway (GO:0038180)2.22646878
141regulation of Rac protein signal transduction (GO:0035020)2.22052436
142gamma-aminobutyric acid transport (GO:0015812)2.21810956
143dendritic spine organization (GO:0097061)2.21592513
144positive regulation of synaptic transmission, GABAergic (GO:0032230)2.21371089
145glomerular visceral epithelial cell development (GO:0072015)10.0040925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46880396
2GBX2_23144817_ChIP-Seq_PC3_Human3.35828352
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68383549
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68086674
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63901704
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43493782
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43493782
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37279583
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30337865
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.28705085
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23388845
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20846070
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.18448803
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16718549
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16577399
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16132697
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09365747
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06603697
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.06252024
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06019905
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.05866974
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99194558
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.94571481
24DROSHA_22980978_ChIP-Seq_HELA_Human1.91594512
25* REST_21632747_ChIP-Seq_MESCs_Mouse1.91285621
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86478223
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83835878
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81942592
29VDR_22108803_ChIP-Seq_LS180_Human1.74337218
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70109817
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66348627
32FUS_26573619_Chip-Seq_HEK293_Human1.64727289
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64001955
34TAF15_26573619_Chip-Seq_HEK293_Human1.60361570
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57402553
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.56406853
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55750927
38EWS_26573619_Chip-Seq_HEK293_Human1.51923863
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50266082
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49889182
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48831465
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47690003
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.42071946
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41412554
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41054011
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40784649
47P300_19829295_ChIP-Seq_ESCs_Human1.40084147
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38931917
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.38466502
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.37641945
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36782693
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36540370
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.36370761
54* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36345185
55* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35680803
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34872237
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34866025
58AR_21572438_ChIP-Seq_LNCaP_Human1.33066861
59AHR_22903824_ChIP-Seq_MCF-7_Human1.32212927
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31169626
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31105746
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.30688702
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.28783715
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.28370676
65AR_25329375_ChIP-Seq_VCAP_Human1.28204051
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27234426
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27172444
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26252893
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25965579
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25919603
71RNF2_27304074_Chip-Seq_NSC_Mouse1.25564209
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25391595
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24779786
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.24625509
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23713550
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23700050
77ZNF274_21170338_ChIP-Seq_K562_Hela1.20956983
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20682762
79IGF1R_20145208_ChIP-Seq_DFB_Human1.17163502
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17162961
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15853541
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15486569
83CBP_20019798_ChIP-Seq_JUKART_Human1.15126565
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15126565
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.13653422
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12120310
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11416436
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.11373592
89BCAT_22108803_ChIP-Seq_LS180_Human1.11217438
90ER_23166858_ChIP-Seq_MCF-7_Human1.10026183
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.09504091
92* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09317703
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08924296
94STAT3_23295773_ChIP-Seq_U87_Human1.07462394
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07071996
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.06846840
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05992018
98RUNX2_22187159_ChIP-Seq_PCA_Human1.05506925
99* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05383389
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04813757
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03953650
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03623178
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.02859681
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02670139
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.02015204
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97894781
107* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96993777
108* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96789858
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96327742
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96327742
111* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95898374
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.94635740
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.94059552
114TCF4_23295773_ChIP-Seq_U87_Human0.93597220
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.92609822
116AR_19668381_ChIP-Seq_PC3_Human0.92566911
117KDM2B_26808549_Chip-Seq_REH_Human0.91345435
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.91166542
119JUN_21703547_ChIP-Seq_K562_Human0.91144672
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90598230
121TP53_18474530_ChIP-ChIP_U2OS_Human0.90595319
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90587123
123VDR_24787735_ChIP-Seq_THP-1_Human0.90452331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.26786919
2MP0003880_abnormal_central_pattern4.63174902
3MP0002822_catalepsy4.36597167
4MP0005423_abnormal_somatic_nervous3.61694035
5MP0003635_abnormal_synaptic_transmissio3.25983112
6MP0000569_abnormal_digit_pigmentation3.22951341
7MP0002102_abnormal_ear_morphology3.09707375
8MP0002063_abnormal_learning/memory/cond2.90935142
9MP0004270_analgesia2.56793734
10MP0001486_abnormal_startle_reflex2.55986103
11* MP0009745_abnormal_behavioral_response2.51600705
12MP0006276_abnormal_autonomic_nervous2.50605679
13MP0000778_abnormal_nervous_system2.49544877
14MP0002572_abnormal_emotion/affect_behav2.48015137
15* MP0002064_seizures2.37619938
16MP0010386_abnormal_urinary_bladder2.25868002
17MP0001968_abnormal_touch/_nociception2.19274485
18MP0003303_peritoneal_inflammation2.13071979
19MP0002735_abnormal_chemical_nociception2.12962872
20MP0000566_synostosis2.11702203
21MP0009046_muscle_twitch2.07294522
22MP0003283_abnormal_digestive_organ2.07015127
23MP0005623_abnormal_meninges_morphology2.04012468
24MP0002734_abnormal_mechanical_nocicepti2.03457286
25MP0001440_abnormal_grooming_behavior1.94061577
26MP0003690_abnormal_glial_cell1.86183204
27MP0002184_abnormal_innervation1.80340308
28MP0003121_genomic_imprinting1.79982298
29MP0001501_abnormal_sleep_pattern1.76566780
30MP0002557_abnormal_social/conspecific_i1.72169912
31MP0001986_abnormal_taste_sensitivity1.72059454
32MP0002272_abnormal_nervous_system1.68677887
33MP0005645_abnormal_hypothalamus_physiol1.68227853
34MP0003890_abnormal_embryonic-extraembry1.67322511
35MP0002751_abnormal_autonomic_nervous1.65025416
36MP0003172_abnormal_lysosome_physiology1.62803906
37MP0002067_abnormal_sensory_capabilities1.62750250
38MP0002733_abnormal_thermal_nociception1.62465867
39MP0009780_abnormal_chondrocyte_physiolo1.60896229
40MP0001905_abnormal_dopamine_level1.60564872
41MP0004858_abnormal_nervous_system1.58596005
42MP0003787_abnormal_imprinting1.58132744
43MP0002736_abnormal_nociception_after1.56331453
44MP0001529_abnormal_vocalization1.55570695
45MP0005499_abnormal_olfactory_system1.52354071
46MP0005394_taste/olfaction_phenotype1.52354071
47MP0002234_abnormal_pharynx_morphology1.48275420
48MP0000920_abnormal_myelination1.47809290
49MP0002653_abnormal_ependyma_morphology1.47682642
50MP0001970_abnormal_pain_threshold1.47362199
51MP0002909_abnormal_adrenal_gland1.43648241
52MP0004133_heterotaxia1.42412862
53MP0004811_abnormal_neuron_physiology1.41670337
54MP0003329_amyloid_beta_deposits1.39410215
55MP0005386_behavior/neurological_phenoty1.39218401
56MP0004924_abnormal_behavior1.39218401
57MP0003634_abnormal_glial_cell1.38713502
58MP0002882_abnormal_neuron_morphology1.35136527
59MP0004742_abnormal_vestibular_system1.32923245
60MP0006082_CNS_inflammation1.32521334
61MP0003183_abnormal_peptide_metabolism1.29044751
62MP0000955_abnormal_spinal_cord1.24576971
63MP0005646_abnormal_pituitary_gland1.21599840
64MP0002066_abnormal_motor_capabilities/c1.21456052
65MP0005253_abnormal_eye_physiology1.16065309
66MP0001502_abnormal_circadian_rhythm1.15294830
67MP0001963_abnormal_hearing_physiology1.14674427
68MP0002152_abnormal_brain_morphology1.11028807
69MP0008789_abnormal_olfactory_epithelium1.10630383
70MP0000604_amyloidosis1.09673948
71MP0002090_abnormal_vision1.08288021
72MP0008961_abnormal_basal_metabolism1.06557316
73MP0005197_abnormal_uvea_morphology1.05624640
74MP0000230_abnormal_systemic_arterial1.00956903
75MP0006072_abnormal_retinal_apoptosis1.00458839
76MP0004510_myositis0.99800671
77MP0008569_lethality_at_weaning0.98550858
78MP0002928_abnormal_bile_duct0.98223836
79MP0004885_abnormal_endolymph0.97459093
80MP0005058_abnormal_lysosome_morphology0.96868302
81MP0003879_abnormal_hair_cell0.95855394
82MP0002638_abnormal_pupillary_reflex0.94918587
83MP0001485_abnormal_pinna_reflex0.94887003
84MP0002938_white_spotting0.94460836
85MP0003011_delayed_dark_adaptation0.93054832
86MP0003136_yellow_coat_color0.91366595
87MP0002752_abnormal_somatic_nervous0.91036602
88MP0006292_abnormal_olfactory_placode0.87869378
89MP0008877_abnormal_DNA_methylation0.87617100
90MP0002229_neurodegeneration0.86738199
91MP0002282_abnormal_trachea_morphology0.86405927
92MP0005551_abnormal_eye_electrophysiolog0.84915352
93MP0005391_vision/eye_phenotype0.83386503
94MP0005409_darkened_coat_color0.82978229
95MP0003119_abnormal_digestive_system0.82444248
96MP0003633_abnormal_nervous_system0.79445698
97MP0000049_abnormal_middle_ear0.78374548
98MP0003075_altered_response_to0.77979756
99MP0002069_abnormal_eating/drinking_beha0.77867401
100MP0003315_abnormal_perineum_morphology0.77583794
101MP0001984_abnormal_olfaction0.77570615
102MP0000026_abnormal_inner_ear0.76932734
103MP0005167_abnormal_blood-brain_barrier0.76902343
104MP0004142_abnormal_muscle_tone0.76686999
105MP0001188_hyperpigmentation0.76535851
106MP0002998_abnormal_bone_remodeling0.75513481
107MP0001293_anophthalmia0.74242303
108MP0005084_abnormal_gallbladder_morpholo0.73129142
109MP0000015_abnormal_ear_pigmentation0.72212176
110MP0005195_abnormal_posterior_eye0.71987022
111MP0004272_abnormal_basement_membrane0.71922022
112MP0003631_nervous_system_phenotype0.71568634
113MP0001879_abnormal_lymphatic_vessel0.70904119
114MP0003632_abnormal_nervous_system0.66297285
115MP0004145_abnormal_muscle_electrophysio0.65729860
116MP0005310_abnormal_salivary_gland0.65276977
117MP0003942_abnormal_urinary_system0.64602460
118MP0001835_abnormal_antigen_presentation0.63979972
119MP0001324_abnormal_eye_pigmentation0.63704330
120MP0004134_abnormal_chest_morphology0.63178516
121MP0001299_abnormal_eye_distance/0.62066664
122MP0004084_abnormal_cardiac_muscle0.61866366
123MP0003861_abnormal_nervous_system0.60488899
124MP0003122_maternal_imprinting0.59371609
125MP0000538_abnormal_urinary_bladder0.58901494
126MP0000534_abnormal_ureter_morphology0.58610144
127MP0004085_abnormal_heartbeat0.58369240
128MP0000631_abnormal_neuroendocrine_gland0.58312208
129MP0002277_abnormal_respiratory_mucosa0.57209498
130MP0005187_abnormal_penis_morphology0.56727609
131MP0003938_abnormal_ear_development0.54668718

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)4.94884033
2Glomerulonephritis (HP:0000099)4.92174494
3* Focal segmental glomerulosclerosis (HP:0000097)4.20530921
4Focal motor seizures (HP:0011153)4.14496813
5Cortical dysplasia (HP:0002539)4.14401502
6Mutism (HP:0002300)4.07750232
7Nephritis (HP:0000123)3.86328233
8Neurofibrillary tangles (HP:0002185)3.74527177
9True hermaphroditism (HP:0010459)3.68320920
10Supranuclear gaze palsy (HP:0000605)3.63902787
11Pancreatic fibrosis (HP:0100732)3.37427272
12Stage 5 chronic kidney disease (HP:0003774)3.34028013
13Focal seizures (HP:0007359)3.33109894
14Inappropriate behavior (HP:0000719)3.30980032
15Recurrent abscess formation (HP:0002722)3.30373693
16Myokymia (HP:0002411)3.27758245
17* Hypoalbuminemia (HP:0003073)3.27118446
18* Abnormal albumin level (HP:0012116)3.27118446
19Pancreatic cysts (HP:0001737)3.26491607
20Gait imbalance (HP:0002141)3.16867756
21Abnormal ciliary motility (HP:0012262)3.16256579
22Abnormality of the labia minora (HP:0012880)3.09618064
23Agitation (HP:0000713)3.07916659
24Disinhibition (HP:0000734)3.03281924
25Febrile seizures (HP:0002373)3.02284830
26Cerebral inclusion bodies (HP:0100314)3.02085589
27Abnormal respiratory motile cilium morphology (HP:0005938)3.01530315
28Abnormal respiratory epithelium morphology (HP:0012253)3.01530315
29Polyphagia (HP:0002591)2.99150627
30Rapidly progressive (HP:0003678)2.95805444
31Retinal dysplasia (HP:0007973)2.95228222
32Epileptic encephalopathy (HP:0200134)2.93697170
33* Glomerulosclerosis (HP:0000096)2.89189626
34Abnormality of midbrain morphology (HP:0002418)2.86079450
35Molar tooth sign on MRI (HP:0002419)2.86079450
36Excessive salivation (HP:0003781)2.84122184
37Drooling (HP:0002307)2.84122184
38Specific learning disability (HP:0001328)2.81779084
39Nephronophthisis (HP:0000090)2.78866131
40* Nephrotic syndrome (HP:0000100)2.78431302
41Abnormal respiratory motile cilium physiology (HP:0012261)2.75627616
42Medial flaring of the eyebrow (HP:0010747)2.73874163
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73614428
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73229598
45Exotropia (HP:0000577)2.68142084
46Esotropia (HP:0000565)2.64425119
47Blue irides (HP:0000635)2.63176878
48Tubular atrophy (HP:0000092)2.61707849
49Visual hallucinations (HP:0002367)2.61635000
50Congenital primary aphakia (HP:0007707)2.60151424
51Limb dystonia (HP:0002451)2.58558292
52Atonic seizures (HP:0010819)2.50718610
53Genital tract atresia (HP:0001827)2.49906554
54Nephrogenic diabetes insipidus (HP:0009806)2.48264738
55Progressive cerebellar ataxia (HP:0002073)2.47724192
56Urinary bladder sphincter dysfunction (HP:0002839)2.46369706
57Progressive inability to walk (HP:0002505)2.45866402
58Vaginal atresia (HP:0000148)2.43488902
59Neonatal respiratory distress (HP:0002643)2.43339532
60Recurrent bacterial skin infections (HP:0005406)2.43026011
61Abnormality of salivation (HP:0100755)2.39152469
62Broad-based gait (HP:0002136)2.37403232
63Cystic liver disease (HP:0006706)2.37049599
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35704953
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.35704953
66Spastic tetraplegia (HP:0002510)2.34938730
67Urinary urgency (HP:0000012)2.34835085
68Genetic anticipation (HP:0003743)2.33712384
69Neoplasm of the adrenal cortex (HP:0100641)2.32661129
70Apathy (HP:0000741)2.30866747
71Retinal atrophy (HP:0001105)2.29593842
72High anterior hairline (HP:0009890)2.28554753
73Hypsarrhythmia (HP:0002521)2.28504953
74Ankle clonus (HP:0011448)2.27366965
75Type II lissencephaly (HP:0007260)2.26724107
76Papilledema (HP:0001085)2.26250077
77Amblyopia (HP:0000646)2.25310353
78Abnormality of the renal medulla (HP:0100957)2.24342822
79Absent speech (HP:0001344)2.23675861
80Action tremor (HP:0002345)2.23656761
81Impaired vibration sensation in the lower limbs (HP:0002166)2.22849899
82Epileptiform EEG discharges (HP:0011182)2.22807694
83EEG with generalized epileptiform discharges (HP:0011198)2.21088544
84Anencephaly (HP:0002323)2.18585241
85Metaphyseal dysplasia (HP:0100255)2.17600534
86Abnormal eating behavior (HP:0100738)2.17439933
87Pendular nystagmus (HP:0012043)2.17339527
88Akinesia (HP:0002304)2.17209210
89Abnormality of the corticospinal tract (HP:0002492)2.16959873
90Nonprogressive disorder (HP:0003680)2.16931427
91Intellectual disability, moderate (HP:0002342)2.16072643
92Generalized tonic-clonic seizures (HP:0002069)2.13439841
93Anophthalmia (HP:0000528)2.13097651
94Hepatoblastoma (HP:0002884)2.12899843
95Absence seizures (HP:0002121)2.11630313
96Hypoplasia of the corpus callosum (HP:0002079)2.11434951
97Abnormal large intestine physiology (HP:0012700)2.11207762
98Bowel incontinence (HP:0002607)2.11150267
99Chronic hepatic failure (HP:0100626)2.08280921
100Narrow forehead (HP:0000341)2.06666385
101Abnormality of glycolipid metabolism (HP:0010969)2.06583006
102Abnormality of liposaccharide metabolism (HP:0010968)2.06583006
103Abnormality of glycosphingolipid metabolism (HP:0004343)2.06583006
104Protruding tongue (HP:0010808)2.06034930
105Hyperthyroidism (HP:0000836)2.04658466
106Hypoplasia of the brainstem (HP:0002365)2.04507640
107Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04507640
108Failure to thrive in infancy (HP:0001531)2.03926497
109Oligodactyly (hands) (HP:0001180)2.03910035
110Diminished motivation (HP:0000745)2.02959463
111Abnormality of the lower motor neuron (HP:0002366)2.02398499
112Neuronal loss in central nervous system (HP:0002529)2.01774401
113Aplasia/Hypoplasia of the tongue (HP:0010295)2.01709058
114Rhinitis (HP:0012384)2.01638349
115Anomalous pulmonary venous return (HP:0010772)2.00851850
116Increased cerebral lipofuscin (HP:0011813)1.99811446
117Hyperventilation (HP:0002883)1.98964404
118Optic nerve hypoplasia (HP:0000609)1.98742181
119Systemic lupus erythematosus (HP:0002725)1.98145147
120Increased circulating renin level (HP:0000848)1.98141158
121Sclerocornea (HP:0000647)1.97873941
122Ulnar claw (HP:0001178)1.96927502
123Dialeptic seizures (HP:0011146)1.96553169
124Corneal erosion (HP:0200020)1.96042066
125Spastic gait (HP:0002064)1.94933100
126Stomach cancer (HP:0012126)1.91680629
127Lissencephaly (HP:0001339)1.91159294
128Lymphangioma (HP:0100764)1.88067957
129Fetal akinesia sequence (HP:0001989)1.86017367
130Abnormality of binocular vision (HP:0011514)1.83804375
131Diplopia (HP:0000651)1.83804375
132Pheochromocytoma (HP:0002666)1.83557349
133Polymicrogyria (HP:0002126)1.83471527
134Intellectual disability, severe (HP:0010864)1.83177131
135* Proteinuria (HP:0000093)1.82626814
136Morphological abnormality of the pyramidal tract (HP:0002062)1.82183815
137Congenital hepatic fibrosis (HP:0002612)1.82173202
138Hypothermia (HP:0002045)1.82165100
139Atelectasis (HP:0100750)1.82005466
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.80996187
141Absent/shortened dynein arms (HP:0200106)1.80996187
142Obstructive lung disease (HP:0006536)1.79866206
143Chronic obstructive pulmonary disease (HP:0006510)1.79866206
144Generalized myoclonic seizures (HP:0002123)1.79487737
145Hypoproteinemia (HP:0003075)1.79418400
146Concave nail (HP:0001598)1.79238082
147Arterial tortuosity (HP:0005116)1.76122725
148Mediastinal lymphadenopathy (HP:0100721)1.75969123
149Heterochromia iridis (HP:0001100)1.74888150
150Poor eye contact (HP:0000817)1.74883796
151Dysostosis multiplex (HP:0000943)1.74151591
152Aqueductal stenosis (HP:0002410)1.73114765
153Abnormality of calcium-phosphate metabolism (HP:0100530)1.72705759
154Amyotrophic lateral sclerosis (HP:0007354)1.71563767
155Inability to walk (HP:0002540)1.71529605
156Curly hair (HP:0002212)1.70979061
157Hemiparesis (HP:0001269)1.70887725
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.70843058
159Tented upper lip vermilion (HP:0010804)1.66434672
160Recurrent corneal erosions (HP:0000495)1.66305838
161Pachygyria (HP:0001302)1.65598204
162Anosmia (HP:0000458)1.63673058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.17987403
2NTRK33.36456439
3SIK22.76396610
4ICK2.55784077
5MAP3K92.25717306
6NTRK22.17275562
7SIK32.06670777
8OXSR12.06194821
9MAPK132.04527732
10EPHA42.03783738
11MAP4K22.02652339
12MAPK151.93176880
13FES1.92992745
14MINK11.92919628
15EPHB21.92228773
16MAP3K41.89233718
17MAP2K71.83270914
18CASK1.70900507
19TGFBR21.67239770
20PINK11.61933752
21PAK61.61254503
22GRK71.57239115
23RIPK41.56172358
24EPHA31.55628908
25DYRK21.54451377
26DYRK31.52185993
27STK391.49647781
28IRAK21.47897872
29TNIK1.45555854
30TYRO31.40079617
31PKN11.39126767
32NTRK11.37442610
33WNK41.37122891
34ERBB31.32586210
35CDK51.30461569
36PRPF4B1.26882102
37GRK51.21970450
38PHKG11.20055397
39PHKG21.20055397
40FGR1.19751024
41TRIM281.08530232
42KSR11.07834949
43CSNK1G21.02304644
44CDK191.02224673
45DYRK1B0.97560414
46CAMK1G0.95456459
47CAMK2B0.95169576
48NEK10.93816191
49DAPK20.93015947
50CSNK1A1L0.90552497
51PLK20.86361785
52UHMK10.83031228
53SGK20.81656449
54CCNB10.79215984
55PNCK0.79112989
56FRK0.78942433
57LATS20.78427664
58FYN0.78007025
59MAP2K40.77767593
60CSNK1G30.77497448
61DYRK1A0.77201561
62IRAK40.76184948
63PRKCE0.74444274
64CDK180.72628908
65ADRBK20.72592701
66CAMK40.72476175
67PAK30.72399496
68MAP3K60.72302608
69CAMKK10.72269943
70RPS6KA40.71857481
71CDK150.69151772
72CDK140.68924693
73CAMK1D0.67629520
74MARK20.67243344
75KSR20.66727047
76CAMK2A0.66426249
77SGK2230.66339171
78SGK4940.66339171
79PRKCG0.65191191
80PRKCZ0.63823019
81JAK10.61504499
82MAP3K120.60073888
83KIT0.59750394
84LATS10.58726697
85CSK0.56090240
86CDK11A0.55606862
87PAK40.53972600
88PRKCH0.53258653
89STK110.52584231
90IRAK10.52088661
91SGK10.51542697
92TYK20.50633707
93ROCK10.50302674
94WNK30.50158264
95MAP3K130.49844230
96CDK30.48849520
97CSNK1G10.47796624
98TIE10.47758621
99INSRR0.47621113
100NEK60.47133715
101PRKACB0.46598245
102VRK10.46492268
103BMPR20.46288804
104NEK20.45507708
105MAPK120.44652660
106CSF1R0.44591833
107BCR0.44373253
108YES10.43257388
109MAP3K140.42621861
110ERBB20.42222965
111BMPR1B0.42128657
112MAPK90.41534005
113TAOK10.41513788
114RET0.40986518
115PRKG10.40976315
116CAMKK20.40916574
117PDPK10.40753385
118RPS6KA20.40319001
119PDGFRB0.40136175
120EPHB10.39731809
121HCK0.38655374
122BLK0.37995113
123ADRBK10.37367349
124PRKACA0.37296349
125MAPK40.34345227
126MAP3K50.34121942
127STK38L0.32971304
128BRD40.32196099
129MATK0.29159780
130PRKAA10.27794223
131CSNK1A10.26889443
132CAMK10.25916416
133SGK30.25170104
134RPS6KA50.24616773

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17799788
2Synaptic vesicle cycle_Homo sapiens_hsa047212.24113613
3Axon guidance_Homo sapiens_hsa043602.17850210
4GABAergic synapse_Homo sapiens_hsa047271.99448998
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91849722
6Morphine addiction_Homo sapiens_hsa050321.85551000
7Glutamatergic synapse_Homo sapiens_hsa047241.85096910
8Circadian entrainment_Homo sapiens_hsa047131.85014708
9Steroid biosynthesis_Homo sapiens_hsa001001.70563713
10Cholinergic synapse_Homo sapiens_hsa047251.59858451
11Long-term potentiation_Homo sapiens_hsa047201.57445136
12Olfactory transduction_Homo sapiens_hsa047401.53168184
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46716824
14Salivary secretion_Homo sapiens_hsa049701.43733170
15Serotonergic synapse_Homo sapiens_hsa047261.42174024
16Cocaine addiction_Homo sapiens_hsa050301.38510067
17Renin secretion_Homo sapiens_hsa049241.38166926
18Amphetamine addiction_Homo sapiens_hsa050311.37263992
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35932760
20Dopaminergic synapse_Homo sapiens_hsa047281.35019501
21Collecting duct acid secretion_Homo sapiens_hsa049661.34647676
22Dorso-ventral axis formation_Homo sapiens_hsa043201.24437497
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22394330
24Long-term depression_Homo sapiens_hsa047301.20871011
25Renal cell carcinoma_Homo sapiens_hsa052111.20689412
26Taste transduction_Homo sapiens_hsa047421.19434206
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19300837
28Oxytocin signaling pathway_Homo sapiens_hsa049211.19130570
29Gap junction_Homo sapiens_hsa045401.18862763
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18694714
31Alcoholism_Homo sapiens_hsa050341.17626377
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17102312
33Phagosome_Homo sapiens_hsa041451.16936878
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15382731
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14857067
36Gastric acid secretion_Homo sapiens_hsa049711.14752438
37Calcium signaling pathway_Homo sapiens_hsa040201.13966696
38GnRH signaling pathway_Homo sapiens_hsa049121.12793296
39ErbB signaling pathway_Homo sapiens_hsa040121.11270363
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10405344
41Insulin secretion_Homo sapiens_hsa049111.08085036
42Cardiac muscle contraction_Homo sapiens_hsa042601.07456104
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07063226
44Rheumatoid arthritis_Homo sapiens_hsa053231.06895478
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05873636
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02919460
47Lysosome_Homo sapiens_hsa041421.00977162
48Oxidative phosphorylation_Homo sapiens_hsa001900.99249370
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99245453
50Glioma_Homo sapiens_hsa052140.98646103
51Ether lipid metabolism_Homo sapiens_hsa005650.95991933
52Estrogen signaling pathway_Homo sapiens_hsa049150.95752574
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95702851
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.95184007
55cAMP signaling pathway_Homo sapiens_hsa040240.94672527
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94652360
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94542277
58Chemokine signaling pathway_Homo sapiens_hsa040620.94144997
59Endometrial cancer_Homo sapiens_hsa052130.92694817
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91033850
61Hedgehog signaling pathway_Homo sapiens_hsa043400.89770900
62Regulation of autophagy_Homo sapiens_hsa041400.87844681
63Parkinsons disease_Homo sapiens_hsa050120.87635508
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.87457718
65Tuberculosis_Homo sapiens_hsa051520.87178409
66Type II diabetes mellitus_Homo sapiens_hsa049300.86245246
67Dilated cardiomyopathy_Homo sapiens_hsa054140.85408733
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85086830
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82808962
70Prion diseases_Homo sapiens_hsa050200.82735132
71Basal cell carcinoma_Homo sapiens_hsa052170.81647141
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81616723
73Osteoclast differentiation_Homo sapiens_hsa043800.81218189
74Vibrio cholerae infection_Homo sapiens_hsa051100.80422472
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.80273074
76Choline metabolism in cancer_Homo sapiens_hsa052310.79094697
77Ras signaling pathway_Homo sapiens_hsa040140.78646059
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78013494
79Butanoate metabolism_Homo sapiens_hsa006500.77134820
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77078106
81Amoebiasis_Homo sapiens_hsa051460.76649673
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75715006
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75079120
84MAPK signaling pathway_Homo sapiens_hsa040100.74211785
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73433766
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71652498
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.71483058
88B cell receptor signaling pathway_Homo sapiens_hsa046620.69599884
89Renin-angiotensin system_Homo sapiens_hsa046140.69530434
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68288703
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.67973099
92Linoleic acid metabolism_Homo sapiens_hsa005910.67504631
93Salmonella infection_Homo sapiens_hsa051320.67003908
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.66636342
95Rap1 signaling pathway_Homo sapiens_hsa040150.66620474
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66161985
97Phototransduction_Homo sapiens_hsa047440.65799034
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65068057
99Other glycan degradation_Homo sapiens_hsa005110.64885637
100Focal adhesion_Homo sapiens_hsa045100.64597800
101ECM-receptor interaction_Homo sapiens_hsa045120.63894624
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63136135
103Leishmaniasis_Homo sapiens_hsa051400.62707002
104Alzheimers disease_Homo sapiens_hsa050100.61876772
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61738339
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60750213
107Endocytosis_Homo sapiens_hsa041440.60737716
108Sphingolipid metabolism_Homo sapiens_hsa006000.60636514
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59738577
110Melanogenesis_Homo sapiens_hsa049160.59439582
111Colorectal cancer_Homo sapiens_hsa052100.59279395
112Pertussis_Homo sapiens_hsa051330.58889245
113Graft-versus-host disease_Homo sapiens_hsa053320.58781471
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58483285
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58264653
116VEGF signaling pathway_Homo sapiens_hsa043700.57766330
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57694056
118Pancreatic cancer_Homo sapiens_hsa052120.57073035
119Staphylococcus aureus infection_Homo sapiens_hsa051500.56036327
120Viral myocarditis_Homo sapiens_hsa054160.55271772
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.51744156
122Huntingtons disease_Homo sapiens_hsa050160.46440879
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45709158
124Wnt signaling pathway_Homo sapiens_hsa043100.44515279
125Prolactin signaling pathway_Homo sapiens_hsa049170.40605307
126Hippo signaling pathway_Homo sapiens_hsa043900.39868661
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38175897
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35045218
129Ovarian steroidogenesis_Homo sapiens_hsa049130.30741515
130Basal transcription factors_Homo sapiens_hsa030220.27644593
131Asthma_Homo sapiens_hsa053100.27421720
132Tryptophan metabolism_Homo sapiens_hsa003800.25940730
133Oocyte meiosis_Homo sapiens_hsa041140.24085476

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