PTPRS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90552807
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83485255
3vocalization behavior (GO:0071625)4.77180873
4neuron cell-cell adhesion (GO:0007158)4.73139348
5layer formation in cerebral cortex (GO:0021819)4.60210129
6locomotory exploration behavior (GO:0035641)4.56905661
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.49881168
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.39305528
9axonal fasciculation (GO:0007413)4.38201925
10protein localization to synapse (GO:0035418)4.35038862
11synaptic vesicle maturation (GO:0016188)4.30196660
12regulation of glutamate receptor signaling pathway (GO:1900449)4.28363650
13neuron recognition (GO:0008038)4.25400734
14paraxial mesoderm development (GO:0048339)4.19455294
15dendritic spine morphogenesis (GO:0060997)4.17190975
16cell migration in hindbrain (GO:0021535)4.13539828
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.10976845
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.09361739
19positive regulation of synapse maturation (GO:0090129)4.08842660
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94529078
21central nervous system projection neuron axonogenesis (GO:0021952)3.91127831
22postsynaptic membrane organization (GO:0001941)3.88677185
23synaptic vesicle exocytosis (GO:0016079)3.85057685
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.81677921
25exploration behavior (GO:0035640)3.77993250
26glutamate secretion (GO:0014047)3.77588448
27regulation of synaptic vesicle exocytosis (GO:2000300)3.76191953
28dendrite morphogenesis (GO:0048813)3.65930967
29regulation of synapse structural plasticity (GO:0051823)3.64286727
30regulation of neuronal synaptic plasticity (GO:0048168)3.58403287
31neurotransmitter-gated ion channel clustering (GO:0072578)3.53528590
32synaptic transmission, glutamatergic (GO:0035249)3.52551826
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47197300
34convergent extension (GO:0060026)3.40537994
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40004260
36glutamate receptor signaling pathway (GO:0007215)3.37558680
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34115449
38regulation of synapse maturation (GO:0090128)3.32233419
39regulation of synaptic vesicle transport (GO:1902803)3.27656960
40establishment of nucleus localization (GO:0040023)3.23013868
41presynaptic membrane assembly (GO:0097105)3.22386283
42pyrimidine nucleobase catabolic process (GO:0006208)3.19233117
43innervation (GO:0060384)3.17558633
44neurotransmitter secretion (GO:0007269)3.17556296
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.11743639
46neuron-neuron synaptic transmission (GO:0007270)3.10529524
47synaptic vesicle endocytosis (GO:0048488)3.08894885
48regulation of dendritic spine morphogenesis (GO:0061001)3.08786847
49cerebellar Purkinje cell differentiation (GO:0021702)3.06903118
50Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.06816450
51cerebral cortex radially oriented cell migration (GO:0021799)3.05644009
52axon extension (GO:0048675)3.05392576
53auditory behavior (GO:0031223)3.04316075
54cerebellar granule cell differentiation (GO:0021707)3.04137418
55central nervous system neuron axonogenesis (GO:0021955)3.03767748
56presynaptic membrane organization (GO:0097090)3.03481355
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03289196
58proline transport (GO:0015824)3.02780434
59dendritic spine organization (GO:0097061)3.02615502
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01960645
61positive regulation of synapse assembly (GO:0051965)2.99621383
62apical protein localization (GO:0045176)2.98094917
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97513110
64regulation of establishment of planar polarity (GO:0090175)2.95333299
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93579423
66semaphorin-plexin signaling pathway (GO:0071526)2.92535973
67response to auditory stimulus (GO:0010996)2.91735254
68regulation of postsynaptic membrane potential (GO:0060078)2.91697985
69camera-type eye morphogenesis (GO:0048593)2.91046206
70glial cell proliferation (GO:0014009)2.90816185
71positive regulation of membrane potential (GO:0045838)2.89144855
72regulation of NFAT protein import into nucleus (GO:0051532)2.86271603
73synapse assembly (GO:0007416)2.84137635
74establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.84051768
75cell communication by electrical coupling (GO:0010644)2.81837135
76neuromuscular process controlling balance (GO:0050885)2.81826490
77long-term memory (GO:0007616)2.80378420
78neuronal action potential propagation (GO:0019227)2.80354693
79regulation of axon extension involved in axon guidance (GO:0048841)2.79565799
80establishment of mitochondrion localization (GO:0051654)2.77720017
81myelination in peripheral nervous system (GO:0022011)2.77628975
82peripheral nervous system axon ensheathment (GO:0032292)2.77628975
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.76674962
84regulation of synaptic plasticity (GO:0048167)2.76551043
85regulation of synapse organization (GO:0050807)2.75754180
86positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75400715
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75370658
88neuronal ion channel clustering (GO:0045161)2.75192272
89transmission of nerve impulse (GO:0019226)2.75183768
90nucleobase catabolic process (GO:0046113)2.73552397
91positive regulation of synaptic transmission, GABAergic (GO:0032230)2.72898149
92regulation of axon guidance (GO:1902667)2.72813832
93negative regulation of dendrite development (GO:2000171)2.72172374
94negative regulation of axon extension (GO:0030517)2.70530878
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69395566
96response to pheromone (GO:0019236)2.69234953
97regulation of neurotransmitter secretion (GO:0046928)2.68914964
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.68576201
99negative regulation of axon extension involved in axon guidance (GO:0048843)2.67381784
100neuron projection extension (GO:1990138)2.66890078
101synapse organization (GO:0050808)2.66316051
102positive regulation of dendritic spine development (GO:0060999)2.66298279
103establishment or maintenance of bipolar cell polarity (GO:0061245)2.65842406
104establishment or maintenance of apical/basal cell polarity (GO:0035088)2.65842406
105regulation of synapse assembly (GO:0051963)2.65761040
106embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65412801
107gamma-aminobutyric acid transport (GO:0015812)2.65013724
108negative regulation of microtubule polymerization (GO:0031115)2.62374861
109non-canonical Wnt signaling pathway (GO:0035567)2.62292749
110G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.62121345
111regulation of dendritic spine development (GO:0060998)2.61678525
112regulation of respiratory system process (GO:0044065)2.60465709
113membrane depolarization during action potential (GO:0086010)2.59449221
114negative regulation of axon guidance (GO:1902668)2.59162201
115regulation of dendrite morphogenesis (GO:0048814)2.58870892
116neuron projection extension involved in neuron projection guidance (GO:1902284)2.58195243
117axon extension involved in axon guidance (GO:0048846)2.58195243
118notochord development (GO:0030903)2.57688063
119neural tube development (GO:0021915)2.57405875
120dendrite development (GO:0016358)2.56710231
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56360646
122membrane depolarization (GO:0051899)2.55467061
123negative regulation of catenin import into nucleus (GO:0035414)2.54657697
124cochlea morphogenesis (GO:0090103)2.53904374
125mitochondrion transport along microtubule (GO:0047497)2.51718432
126establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51718432
127lateral sprouting from an epithelium (GO:0060601)2.51482790
128cerebellar Purkinje cell layer development (GO:0021680)2.48458938
129asymmetric protein localization (GO:0008105)2.46887680
130positive regulation of dendrite morphogenesis (GO:0050775)2.46570977
131mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.46133221
132dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45513062
133nucleosome disassembly (GO:0006337)2.43526027
134protein-DNA complex disassembly (GO:0032986)2.43526027
135morphogenesis of an epithelial sheet (GO:0002011)2.41871350
136protein heterotrimerization (GO:0070208)2.39657992
137neuronal stem cell maintenance (GO:0097150)2.37532640
138cellular response to prostaglandin stimulus (GO:0071379)2.35248923
139forebrain development (GO:0030900)2.34868615
140insulin-like growth factor receptor signaling pathway (GO:0048009)2.34243014
141cell-cell junction maintenance (GO:0045217)2.34063799
142membrane assembly (GO:0071709)2.33058782
143outer ear morphogenesis (GO:0042473)2.32422685
144stress granule assembly (GO:0034063)2.31041343
145cranial nerve morphogenesis (GO:0021602)2.30526953
146adherens junction assembly (GO:0034333)2.30095446
147neuromuscular junction development (GO:0007528)2.27816396
148establishment of apical/basal cell polarity (GO:0035089)2.27276723
149suckling behavior (GO:0001967)2.26132898
150lens morphogenesis in camera-type eye (GO:0002089)2.24800989
151eye morphogenesis (GO:0048592)2.24244513
152establishment of tissue polarity (GO:0007164)2.23763849
153establishment of planar polarity (GO:0001736)2.23763849
154negative regulation of chondrocyte differentiation (GO:0032331)2.21710304
155calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.21119350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12047271
2GBX2_23144817_ChIP-Seq_PC3_Human3.22154769
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05713392
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91550466
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87713343
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87713343
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86363086
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.81685382
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67641579
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58745169
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.55333254
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49503156
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.42592966
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41402637
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.30913505
16DROSHA_22980978_ChIP-Seq_HELA_Human2.27999010
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27166469
18REST_21632747_ChIP-Seq_MESCs_Mouse2.25252184
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25076809
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23849329
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21803100
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18842854
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18799959
24* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14634810
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14570569
26* RARB_27405468_Chip-Seq_BRAIN_Mouse2.11512361
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85155948
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.80531891
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75778782
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70914326
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.67564592
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61889550
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61150607
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59345502
35AR_21572438_ChIP-Seq_LNCaP_Human1.58955931
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58797504
37* RING1B_27294783_Chip-Seq_ESCs_Mouse1.57704508
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.54678066
39* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54669141
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50407010
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49935230
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49824153
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47405581
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44090915
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43172881
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.41201857
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.38238322
48SMAD4_21799915_ChIP-Seq_A2780_Human1.38056483
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36885671
50* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35928017
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32790080
52ZNF274_21170338_ChIP-Seq_K562_Hela1.32759280
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.30829660
54* KDM2B_26808549_Chip-Seq_K562_Human1.30159846
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29196499
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29022758
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28537674
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27079830
59AHR_22903824_ChIP-Seq_MCF-7_Human1.26910830
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.26250026
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.26240012
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25603388
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25473423
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.23818107
65AR_19668381_ChIP-Seq_PC3_Human1.23597735
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22900636
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22656660
68* CLOCK_20551151_ChIP-Seq_293T_Human1.20977460
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18286117
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17581631
71P300_19829295_ChIP-Seq_ESCs_Human1.17516628
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17199280
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16760492
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16607316
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16521301
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16495325
77POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16052387
78* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16015192
79* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14393529
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13509738
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13022036
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12013154
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.11842150
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10642326
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10642326
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10176791
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10176791
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10176791
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09409041
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.08463113
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08110765
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06868128
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06102177
94* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05787703
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05755047
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05591241
97* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05302189
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04391897
99TAF15_26573619_Chip-Seq_HEK293_Human1.04164805
100AR_25329375_ChIP-Seq_VCAP_Human1.03819411
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.03202009
102* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02864773
103KDM2B_26808549_Chip-Seq_DND41_Human1.02797091
104SMAD3_21741376_ChIP-Seq_ESCs_Human1.02314242
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02214603
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01606548
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01203968
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00933267
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.00481301
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00123939
111* STAT3_23295773_ChIP-Seq_U87_Human0.99795940
112CTCF_27219007_Chip-Seq_Bcells_Human0.99531433
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99503754
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99411459
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.99192765
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.99039251
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98876938
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.97201347
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.95927237
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95772756
121LXR_22292898_ChIP-Seq_THP-1_Human0.95294698
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94991283
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94046287
124* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93661370
125* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93625523
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93244835
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93106340
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.93005015
129* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92983546
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92874637
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.91961628
132IGF1R_20145208_ChIP-Seq_DFB_Human0.91864146
133SOX9_26525672_Chip-Seq_HEART_Mouse0.91836254
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91697726
135* TCF4_23295773_ChIP-Seq_U87_Human0.91368968
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91156181
137RUNX2_22187159_ChIP-Seq_PCA_Human0.90923331
138PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90825188
139TP53_16413492_ChIP-PET_HCT116_Human0.90619181
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90372503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.21134657
2MP0003880_abnormal_central_pattern3.72717642
3MP0003635_abnormal_synaptic_transmissio3.25707280
4MP0004270_analgesia3.01142503
5MP0000778_abnormal_nervous_system2.82578233
6MP0002063_abnormal_learning/memory/cond2.73991442
7MP0005423_abnormal_somatic_nervous2.61700286
8MP0003705_abnormal_hypodermis_morpholog2.48897704
9MP0009745_abnormal_behavioral_response2.44000509
10MP0002064_seizures2.22568204
11MP0001968_abnormal_touch/_nociception2.16377137
12MP0002572_abnormal_emotion/affect_behav2.14131322
13MP0002184_abnormal_innervation2.13102828
14MP0003787_abnormal_imprinting2.09275736
15MP0002734_abnormal_mechanical_nocicepti2.09005900
16MP0009046_muscle_twitch2.07371070
17MP0005499_abnormal_olfactory_system1.94601125
18MP0005394_taste/olfaction_phenotype1.94601125
19MP0001486_abnormal_startle_reflex1.94597668
20MP0003122_maternal_imprinting1.93236752
21MP0008438_abnormal_cutaneous_collagen1.84920523
22MP0002735_abnormal_chemical_nociception1.84053463
23MP0005257_abnormal_intraocular_pressure1.79244668
24MP0004811_abnormal_neuron_physiology1.77842270
25MP0002272_abnormal_nervous_system1.74989221
26MP0000569_abnormal_digit_pigmentation1.74063090
27MP0000955_abnormal_spinal_cord1.73817323
28MP0002736_abnormal_nociception_after1.73413025
29MP0006276_abnormal_autonomic_nervous1.72916547
30MP0008789_abnormal_olfactory_epithelium1.72703033
31MP0002557_abnormal_social/conspecific_i1.68541046
32MP0009780_abnormal_chondrocyte_physiolo1.64773134
33MP0004272_abnormal_basement_membrane1.64392181
34MP0005409_darkened_coat_color1.59074101
35MP0002067_abnormal_sensory_capabilities1.58700052
36* MP0002882_abnormal_neuron_morphology1.53746584
37MP0002697_abnormal_eye_size1.52326820
38MP0005076_abnormal_cell_differentiation1.52187943
39MP0000537_abnormal_urethra_morphology1.49513386
40MP0004885_abnormal_endolymph1.48008197
41MP0002733_abnormal_thermal_nociception1.44119925
42MP0008569_lethality_at_weaning1.42660002
43* MP0002152_abnormal_brain_morphology1.41582109
44MP0001440_abnormal_grooming_behavior1.37614641
45MP0003937_abnormal_limbs/digits/tail_de1.36926652
46MP0002653_abnormal_ependyma_morphology1.36734478
47MP0006292_abnormal_olfactory_placode1.35674367
48MP0001970_abnormal_pain_threshold1.35209460
49MP0001849_ear_inflammation1.34473135
50MP0005645_abnormal_hypothalamus_physiol1.33328274
51* MP0003861_abnormal_nervous_system1.33047285
52MP0005646_abnormal_pituitary_gland1.32894872
53MP0003385_abnormal_body_wall1.31974840
54MP0003121_genomic_imprinting1.31552427
55* MP0004858_abnormal_nervous_system1.29813659
56MP0003136_yellow_coat_color1.29074598
57MP0005623_abnormal_meninges_morphology1.27090125
58MP0001958_emphysema1.25583661
59MP0005386_behavior/neurological_phenoty1.24217862
60MP0004924_abnormal_behavior1.24217862
61MP0001501_abnormal_sleep_pattern1.21277499
62MP0000579_abnormal_nail_morphology1.20121918
63MP0000751_myopathy1.18561111
64MP0002066_abnormal_motor_capabilities/c1.15346066
65MP0009672_abnormal_birth_weight1.14340590
66MP0000534_abnormal_ureter_morphology1.12555509
67MP0002089_abnormal_postnatal_growth/wei1.11530901
68MP0002092_abnormal_eye_morphology1.09124532
69MP0000049_abnormal_middle_ear1.08343007
70MP0003938_abnormal_ear_development1.08243538
71MP0001177_atelectasis1.07062859
72MP0005171_absent_coat_pigmentation1.06939212
73MP0009053_abnormal_anal_canal1.06921280
74* MP0000631_abnormal_neuroendocrine_gland1.06523435
75MP0002751_abnormal_autonomic_nervous1.04950952
76MP0010030_abnormal_orbit_morphology1.04388951
77MP0001502_abnormal_circadian_rhythm1.02830432
78MP0003283_abnormal_digestive_organ1.02460255
79MP0002752_abnormal_somatic_nervous1.02137908
80MP0002234_abnormal_pharynx_morphology0.99766654
81MP0002108_abnormal_muscle_morphology0.99229537
82MP0001299_abnormal_eye_distance/0.99080824
83* MP0001984_abnormal_olfaction0.98719264
84MP0003942_abnormal_urinary_system0.98071361
85MP0001188_hyperpigmentation0.97679774
86MP0000432_abnormal_head_morphology0.96979626
87MP0000733_abnormal_muscle_development0.96719818
88MP0003878_abnormal_ear_physiology0.96651930
89MP0005377_hearing/vestibular/ear_phenot0.96651930
90MP0003755_abnormal_palate_morphology0.94867327
91MP0001348_abnormal_lacrimal_gland0.94546296
92MP0002249_abnormal_larynx_morphology0.93040320
93MP0001293_anophthalmia0.92078916
94MP0004742_abnormal_vestibular_system0.90826495
95MP0002084_abnormal_developmental_patter0.89690276
96MP0002822_catalepsy0.89491549
97MP0005248_abnormal_Harderian_gland0.89283439
98MP0000462_abnormal_digestive_system0.88423697
99MP0005187_abnormal_penis_morphology0.88326479
100MP0002233_abnormal_nose_morphology0.87828656
101MP0004133_heterotaxia0.87732481
102MP0002932_abnormal_joint_morphology0.87269774
103MP0003115_abnormal_respiratory_system0.87238726
104MP0002116_abnormal_craniofacial_bone0.86686815
105MP0002114_abnormal_axial_skeleton0.86090775
106MP0005275_abnormal_skin_tensile0.85861229
107* MP0002081_perinatal_lethality0.85534811
108MP0002085_abnormal_embryonic_tissue0.84992384
109MP0003634_abnormal_glial_cell0.84467901
110MP0003329_amyloid_beta_deposits0.84292335
111MP0009384_cardiac_valve_regurgitation0.84280449
112MP0002102_abnormal_ear_morphology0.84229902
113MP0005508_abnormal_skeleton_morphology0.84022458
114MP0003119_abnormal_digestive_system0.83820491
115MP0000026_abnormal_inner_ear0.83604433
116MP0002909_abnormal_adrenal_gland0.83447551
117MP0009703_decreased_birth_body0.83037190
118MP0002111_abnormal_tail_morphology0.80296328
119MP0009250_abnormal_appendicular_skeleto0.80081070
120MP0001346_abnormal_lacrimal_gland0.79558606
121MP0004197_abnormal_fetal_growth/weight/0.79492781
122MP0001915_intracranial_hemorrhage0.79265584
123MP0000762_abnormal_tongue_morphology0.78307342
124MP0001943_abnormal_respiration0.77461405
125MP0002069_abnormal_eating/drinking_beha0.76433640
126MP0003123_paternal_imprinting0.76257169
127MP0003137_abnormal_impulse_conducting0.74790592
128MP0003935_abnormal_craniofacial_develop0.74746951
129MP0000566_synostosis0.74426605
130MP0001963_abnormal_hearing_physiology0.74386322
131MP0003631_nervous_system_phenotype0.73237690
132MP0003879_abnormal_hair_cell0.72832830
133MP0004233_abnormal_muscle_weight0.72019862
134MP0004085_abnormal_heartbeat0.71725805
135MP0003633_abnormal_nervous_system0.70833667
136MP0000428_abnormal_craniofacial_morphol0.70349868
137MP0001529_abnormal_vocalization0.68947279
138MP0005503_abnormal_tendon_morphology0.68022448

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.13373038
2Myokymia (HP:0002411)3.86575171
3Focal seizures (HP:0007359)3.65916681
4Epileptic encephalopathy (HP:0200134)3.10465139
5Febrile seizures (HP:0002373)2.93699327
6Turricephaly (HP:0000262)2.91975304
7Bronchomalacia (HP:0002780)2.89409939
8Progressive cerebellar ataxia (HP:0002073)2.77525771
9Atonic seizures (HP:0010819)2.70407542
10Protrusio acetabuli (HP:0003179)2.70247777
11Visual hallucinations (HP:0002367)2.68298449
12Neonatal short-limb short stature (HP:0008921)2.65831484
13Hyperacusis (HP:0010780)2.60437354
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52037085
15Short 4th metacarpal (HP:0010044)2.52037085
16Vertebral arch anomaly (HP:0008438)2.51257426
17Insomnia (HP:0100785)2.48940935
18Ankle clonus (HP:0011448)2.42855391
19Vitreoretinal degeneration (HP:0000655)2.40680532
20Drooling (HP:0002307)2.40360678
21Excessive salivation (HP:0003781)2.40360678
22Broad-based gait (HP:0002136)2.39963549
23Action tremor (HP:0002345)2.37745129
24Pointed chin (HP:0000307)2.35795819
25Renal duplication (HP:0000075)2.35777189
26Elfin facies (HP:0004428)2.34215877
27Ulnar bowing (HP:0003031)2.33448557
28Broad metatarsal (HP:0001783)2.32989530
29Genetic anticipation (HP:0003743)2.32987839
30Shallow orbits (HP:0000586)2.32564758
31Premature rupture of membranes (HP:0001788)2.30406930
32Abnormality of the lower motor neuron (HP:0002366)2.29013779
33Megalencephaly (HP:0001355)2.28134111
34Amblyopia (HP:0000646)2.27898058
35Coronal craniosynostosis (HP:0004440)2.25266276
36Renovascular hypertension (HP:0100817)2.23739287
37Wide anterior fontanel (HP:0000260)2.23503009
38Supranuclear gaze palsy (HP:0000605)2.22310657
39Hepatoblastoma (HP:0002884)2.21302339
40High anterior hairline (HP:0009890)2.20957980
41Aqueductal stenosis (HP:0002410)2.19780157
42Impaired vibration sensation in the lower limbs (HP:0002166)2.18446799
43Urinary bladder sphincter dysfunction (HP:0002839)2.17499861
44Overriding aorta (HP:0002623)2.12946907
45Broad thumb (HP:0011304)2.12227138
46Termporal pattern (HP:0011008)2.11223782
47Insidious onset (HP:0003587)2.11223782
48Hyperventilation (HP:0002883)2.11173909
49Narrow nasal bridge (HP:0000446)2.10521911
50Absence seizures (HP:0002121)2.10281000
51Arnold-Chiari malformation (HP:0002308)2.07593995
52Choanal stenosis (HP:0000452)2.01034824
53Flat cornea (HP:0007720)1.99697195
54Morphological abnormality of the middle ear (HP:0008609)1.99371621
55Cerebral aneurysm (HP:0004944)1.98992328
56Tracheomalacia (HP:0002779)1.96771157
57Abnormality of the corticospinal tract (HP:0002492)1.95065171
58Hypoventilation (HP:0002791)1.94334413
59Fetal akinesia sequence (HP:0001989)1.94182186
60Broad long bones (HP:0005622)1.94131497
61Truncal ataxia (HP:0002078)1.93945811
62Poor eye contact (HP:0000817)1.92384161
63Hypoplasia of the brainstem (HP:0002365)1.91393720
64Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91393720
65Obstructive sleep apnea (HP:0002870)1.90038604
66Megalocornea (HP:0000485)1.89987629
67Broad phalanges of the hand (HP:0009768)1.89043880
68Abnormality of dentin (HP:0010299)1.88998281
69Broad palm (HP:0001169)1.88766939
70Generalized tonic-clonic seizures (HP:0002069)1.88159934
71Precocious puberty (HP:0000826)1.87383816
72Broad finger (HP:0001500)1.87293013
73Mild short stature (HP:0003502)1.86762532
74Cutaneous finger syndactyly (HP:0010554)1.86506054
75Abnormality of the 4th metacarpal (HP:0010012)1.86056650
76Limb dystonia (HP:0002451)1.83962840
77Dialeptic seizures (HP:0011146)1.83918719
78Urinary urgency (HP:0000012)1.83253843
79Broad phalanx (HP:0006009)1.83006111
80Bowel diverticulosis (HP:0005222)1.82523291
81Abnormality of the ischium (HP:0003174)1.82387807
82Thin ribs (HP:0000883)1.82261192
83Depression (HP:0000716)1.80932370
84Stereotypic behavior (HP:0000733)1.79491409
85Aplasia involving bones of the extremities (HP:0009825)1.79373033
86Aplasia involving bones of the upper limbs (HP:0009823)1.79373033
87Aplasia of the phalanges of the hand (HP:0009802)1.79373033
88Increased nuchal translucency (HP:0010880)1.79370224
89Neurofibrillary tangles (HP:0002185)1.79213029
90Biconcave vertebral bodies (HP:0004586)1.78537711
91Cortical dysplasia (HP:0002539)1.78451505
92Hammertoe (HP:0001765)1.78411358
93Sacral dimple (HP:0000960)1.77674084
94Mitral valve prolapse (HP:0001634)1.76952679
95Genu recurvatum (HP:0002816)1.76377710
96Absent speech (HP:0001344)1.76117844
97Hemiparesis (HP:0001269)1.76106212
98Broad face (HP:0000283)1.75730302
99Urethral obstruction (HP:0000796)1.75515355
100Overgrowth (HP:0001548)1.75090596
101Lower limb amyotrophy (HP:0007210)1.74618306
102Lower limb muscle weakness (HP:0007340)1.74593014
103Abnormality of the diencephalon (HP:0010662)1.74581201
104Asymmetry of the thorax (HP:0001555)1.74172679
105Pachygyria (HP:0001302)1.73980646
106Vascular tortuosity (HP:0004948)1.73617389
107Impaired social interactions (HP:0000735)1.73079701
108Abnormal social behavior (HP:0012433)1.73079701
109Gaze-evoked nystagmus (HP:0000640)1.72899850
110Lissencephaly (HP:0001339)1.72836211
111Spina bifida occulta (HP:0003298)1.72213996
112Bladder diverticulum (HP:0000015)1.72209682
113Autism (HP:0000717)1.70370370
114Arterial tortuosity (HP:0005116)1.70135685
115Trigonocephaly (HP:0000243)1.68784264
116Exotropia (HP:0000577)1.66717274
117Cutaneous syndactyly (HP:0012725)1.64982321
118Abnormality of the aortic arch (HP:0012303)1.64897410
119Midface retrusion (HP:0011800)1.64767011
120Epileptiform EEG discharges (HP:0011182)1.64147085
121Neoplasm of the heart (HP:0100544)1.64085372
122Shoulder girdle muscle weakness (HP:0003547)1.63834418
123Mitral regurgitation (HP:0001653)1.63677989
124Abnormality of the labia minora (HP:0012880)1.63560908
125Dysdiadochokinesis (HP:0002075)1.62975273
126Blue irides (HP:0000635)1.62937787
127Failure to thrive in infancy (HP:0001531)1.62662862
128Spastic gait (HP:0002064)1.62259466
129Neoplasm of the adrenal cortex (HP:0100641)1.62197201
130Open mouth (HP:0000194)1.62136329
131Torticollis (HP:0000473)1.61715612
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.60456079
133Abnormal eating behavior (HP:0100738)1.60388696
134Protruding tongue (HP:0010808)1.60220156
135Midline defect of the nose (HP:0004122)1.60005570
136Obsessive-compulsive behavior (HP:0000722)1.58968908
137Sleep apnea (HP:0010535)1.58888633
138Abnormality of salivation (HP:0100755)1.58815967
139Shawl scrotum (HP:0000049)1.58436727
140EEG with generalized epileptiform discharges (HP:0011198)1.58312035
141Cerebral inclusion bodies (HP:0100314)1.58052839
142Astrocytoma (HP:0009592)1.57851997
143Abnormality of the astrocytes (HP:0100707)1.57851997
144Omphalocele (HP:0001539)1.57767216
145Abnormality of the calcaneus (HP:0008364)1.56807514
146Tented upper lip vermilion (HP:0010804)1.56177753
147Generalized hypotonia (HP:0001290)1.55685618
148Macroorchidism (HP:0000053)1.55559591
149Wormian bones (HP:0002645)1.55279362
150Patellar dislocation (HP:0002999)1.54029356
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.53998154
152Disproportionate tall stature (HP:0001519)1.52999186
153Lymphangioma (HP:0100764)1.52904637
154Hyperextensible skin (HP:0000974)1.52609499
155Preaxial foot polydactyly (HP:0001841)1.50860221
156Partial duplication of thumb phalanx (HP:0009944)1.50342704
157Deviation of the hallux (HP:0010051)1.49907925
158Dysmetric saccades (HP:0000641)1.49316451
159Soft skin (HP:0000977)1.49048867
160Partial duplication of the phalanx of hand (HP:0009999)1.48403329
161Alacrima (HP:0000522)1.47456805
162Skull defect (HP:0001362)1.46145724
163Laryngomalacia (HP:0001601)1.45257316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.62218221
2NTRK33.49991284
3EPHA43.19922682
4CASK2.59407120
5NTRK22.57413258
6CDK122.56149499
7MINK12.54854923
8MAP3K92.46168241
9MAP3K42.45552199
10PRPF4B2.35860459
11KSR12.26737954
12MAPK132.20992515
13MAP3K102.18602161
14MAP2K72.05114009
15PAK61.94282254
16DAPK21.94229633
17PRKD31.86366489
18SIK21.85903157
19FGFR41.66087418
20ERBB31.62212126
21PLK21.61773530
22EPHB21.58968520
23CAMK1D1.52194012
24UHMK11.47950429
25TYRO31.46632829
26LATS11.45961350
27BRD41.43156569
28SGK21.39805091
29TNIK1.37152019
30EPHA31.34786370
31MTOR1.33506002
32CAMKK11.32729493
33SGK2231.30919779
34SGK4941.30919779
35CDK51.30690283
36PKN21.25739397
37ICK1.25380012
38NTRK11.19199751
39SIK31.17583793
40SMG11.16944279
41SIK11.16169008
42LATS21.15624022
43DDR21.13538183
44RIPK11.12362420
45TTN1.11814332
46MAP2K41.10032851
47SGK31.09613906
48DAPK11.07865548
49PTK21.07511080
50KSR21.07221131
51PDGFRA1.03658115
52PHKG10.99820195
53PHKG20.99820195
54CDK180.95222533
55PRKCG0.93863600
56RPS6KA20.93234158
57DYRK20.93020779
58BCR0.88482204
59CDK150.87556404
60FGFR20.86724931
61PRKCH0.85459582
62PDGFRB0.83150912
63MAP3K120.83040515
64PAK20.82684532
65MARK20.82134996
66CSNK1G20.81223106
67PNCK0.81185988
68PAK30.80799191
69CDK140.79921354
70CAMK1G0.78146505
71DYRK1A0.76967404
72DMPK0.76161138
73CDK11A0.74400309
74MET0.73121588
75ARAF0.73003498
76CDC42BPA0.72272266
77DYRK1B0.72163717
78AKT30.72004014
79STK380.71954082
80RET0.70898855
81ROCK10.70744102
82MAP3K60.69301591
83CAMK2A0.66811244
84LIMK10.65040804
85FGFR30.63840508
86ROCK20.63259259
87SGK10.62971528
88CSNK1A1L0.61969261
89PRKCZ0.60115010
90STK110.59720987
91TAOK10.58984798
92PRKAA10.57630337
93LMTK20.56816854
94BMX0.56020921
95CAMK40.55817509
96GRK50.54737850
97ALK0.53380696
98FER0.51475138
99FGFR10.51123725
100WNK10.50562024
101TAOK20.49268454
102PRKCE0.49064985
103NEK20.47015537
104CAMK10.46978072
105MAPK80.46627892
106CSNK1G30.46564213
107CAMK2B0.46115800
108MKNK10.45936962
109CSNK1G10.45861676
110RAF10.45845191
111ERBB20.45345713
112EEF2K0.44549327
113PTK60.44121742
114TRIB30.43986858
115CDK190.43363074
116RPS6KA30.43250564
117PTK2B0.43033226
118MAP3K20.41459545
119MAPK100.41429906
120MAPK90.41143331
121PKN10.39926129
122PLK30.38977338
123CSNK1D0.38746425
124GSK3B0.37623546
125CDK10.37256996
126PRKDC0.36987489
127PRKD20.36568890
128EPHB10.36361768
129STK38L0.35900729
130MAP2K10.34563960
131FYN0.32866767
132MAP3K70.32724300

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02275298
2Synaptic vesicle cycle_Homo sapiens_hsa047212.56986031
3Olfactory transduction_Homo sapiens_hsa047402.52231436
4Circadian entrainment_Homo sapiens_hsa047132.41171567
5Glutamatergic synapse_Homo sapiens_hsa047242.23412294
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20074030
7GABAergic synapse_Homo sapiens_hsa047272.18300559
8Long-term potentiation_Homo sapiens_hsa047202.10320921
9Morphine addiction_Homo sapiens_hsa050322.09804549
10Axon guidance_Homo sapiens_hsa043602.03482904
11Dopaminergic synapse_Homo sapiens_hsa047281.97607688
12Amphetamine addiction_Homo sapiens_hsa050311.83998393
13Cholinergic synapse_Homo sapiens_hsa047251.82403605
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74476324
15ECM-receptor interaction_Homo sapiens_hsa045121.70893955
16Salivary secretion_Homo sapiens_hsa049701.56937706
17Insulin secretion_Homo sapiens_hsa049111.56582276
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56481276
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55512453
20Taste transduction_Homo sapiens_hsa047421.52459848
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51350658
22Serotonergic synapse_Homo sapiens_hsa047261.49277034
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47536748
24Oxytocin signaling pathway_Homo sapiens_hsa049211.46994187
25Gastric acid secretion_Homo sapiens_hsa049711.46858115
26Glioma_Homo sapiens_hsa052141.46610867
27Gap junction_Homo sapiens_hsa045401.44924377
28Long-term depression_Homo sapiens_hsa047301.44302325
29Endometrial cancer_Homo sapiens_hsa052131.41616685
30Lysine degradation_Homo sapiens_hsa003101.38409106
31Cocaine addiction_Homo sapiens_hsa050301.38171031
32Melanogenesis_Homo sapiens_hsa049161.35920971
33ErbB signaling pathway_Homo sapiens_hsa040121.35423955
34GnRH signaling pathway_Homo sapiens_hsa049121.34931913
35Renin secretion_Homo sapiens_hsa049241.34672422
36Calcium signaling pathway_Homo sapiens_hsa040201.25541661
37Basal cell carcinoma_Homo sapiens_hsa052171.19605524
38Estrogen signaling pathway_Homo sapiens_hsa049151.17375947
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16737334
40Colorectal cancer_Homo sapiens_hsa052101.16716873
41Hedgehog signaling pathway_Homo sapiens_hsa043401.15894011
42cAMP signaling pathway_Homo sapiens_hsa040241.13169830
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12488043
44AMPK signaling pathway_Homo sapiens_hsa041521.12358418
45Type II diabetes mellitus_Homo sapiens_hsa049301.10116608
46Wnt signaling pathway_Homo sapiens_hsa043101.07992329
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.05569306
48Dilated cardiomyopathy_Homo sapiens_hsa054141.05278570
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02890688
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00321804
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96899382
52Hippo signaling pathway_Homo sapiens_hsa043900.96506240
53Oocyte meiosis_Homo sapiens_hsa041140.96366841
54Protein digestion and absorption_Homo sapiens_hsa049740.96016208
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95955713
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95682523
57Phototransduction_Homo sapiens_hsa047440.95321376
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93992602
59Vitamin B6 metabolism_Homo sapiens_hsa007500.88272663
60Prion diseases_Homo sapiens_hsa050200.88205848
61Dorso-ventral axis formation_Homo sapiens_hsa043200.86423320
62MAPK signaling pathway_Homo sapiens_hsa040100.86114119
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84325312
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.83680623
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82831679
66Non-small cell lung cancer_Homo sapiens_hsa052230.82740998
67Alcoholism_Homo sapiens_hsa050340.81106213
68Collecting duct acid secretion_Homo sapiens_hsa049660.80807728
69Rap1 signaling pathway_Homo sapiens_hsa040150.79631835
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78615109
71Prostate cancer_Homo sapiens_hsa052150.78586117
72Ras signaling pathway_Homo sapiens_hsa040140.77094375
73Thyroid cancer_Homo sapiens_hsa052160.77007160
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.76845342
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76796663
76mTOR signaling pathway_Homo sapiens_hsa041500.76740409
77Renal cell carcinoma_Homo sapiens_hsa052110.75793627
78Choline metabolism in cancer_Homo sapiens_hsa052310.75677631
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75642435
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74315130
81Melanoma_Homo sapiens_hsa052180.73446405
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71339791
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70541004
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70463254
85Inositol phosphate metabolism_Homo sapiens_hsa005620.69900703
86VEGF signaling pathway_Homo sapiens_hsa043700.69450877
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68951165
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66822842
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66692408
90Tight junction_Homo sapiens_hsa045300.66574731
91Glucagon signaling pathway_Homo sapiens_hsa049220.64626271
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63944972
93Small cell lung cancer_Homo sapiens_hsa052220.63452765
94Chronic myeloid leukemia_Homo sapiens_hsa052200.62945722
95Focal adhesion_Homo sapiens_hsa045100.62939368
96Vibrio cholerae infection_Homo sapiens_hsa051100.62237719
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62143487
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62056920
99Fatty acid biosynthesis_Homo sapiens_hsa000610.61810373
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61740334
101Proteoglycans in cancer_Homo sapiens_hsa052050.61586893
102Bile secretion_Homo sapiens_hsa049760.61530973
103Bladder cancer_Homo sapiens_hsa052190.61480906
104Cardiac muscle contraction_Homo sapiens_hsa042600.60686689
105Amoebiasis_Homo sapiens_hsa051460.59958230
106Notch signaling pathway_Homo sapiens_hsa043300.58962953
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58655012
108Insulin signaling pathway_Homo sapiens_hsa049100.58650045
109MicroRNAs in cancer_Homo sapiens_hsa052060.57613779
110Adherens junction_Homo sapiens_hsa045200.55090627
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54750076
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53461642
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.53188531
114Endocytosis_Homo sapiens_hsa041440.51579042
115Thyroid hormone synthesis_Homo sapiens_hsa049180.51392159
116Prolactin signaling pathway_Homo sapiens_hsa049170.50384480
117mRNA surveillance pathway_Homo sapiens_hsa030150.49042357
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.48945472
119Pancreatic cancer_Homo sapiens_hsa052120.46647233
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46251170
121Pathways in cancer_Homo sapiens_hsa052000.44568961

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