

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | behavioral response to nicotine (GO:0035095) | 5.49041094 |
| 2 | ribosome assembly (GO:0042255) | 4.83605549 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.71736156 |
| 4 | purine nucleobase biosynthetic process (GO:0009113) | 4.62838912 |
| 5 | formation of translation preinitiation complex (GO:0001731) | 4.46447467 |
| 6 | DNA deamination (GO:0045006) | 4.35682013 |
| 7 | proteasome assembly (GO:0043248) | 4.32878336 |
| 8 | nucleobase biosynthetic process (GO:0046112) | 4.32613468 |
| 9 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 4.28969031 |
| 10 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.28176228 |
| 11 | ribosome biogenesis (GO:0042254) | 4.21056131 |
| 12 | viral transcription (GO:0019083) | 4.18935207 |
| 13 | translational termination (GO:0006415) | 4.16865555 |
| 14 | translational initiation (GO:0006413) | 4.12004558 |
| 15 | ribosomal small subunit biogenesis (GO:0042274) | 4.11428383 |
| 16 | protein complex biogenesis (GO:0070271) | 4.08644685 |
| 17 | ribosomal large subunit biogenesis (GO:0042273) | 4.07935659 |
| 18 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.07050300 |
| 19 | axoneme assembly (GO:0035082) | 4.02754651 |
| 20 | mannosylation (GO:0097502) | 4.02121855 |
| 21 | detection of light stimulus involved in sensory perception (GO:0050962) | 4.01696520 |
| 22 | detection of light stimulus involved in visual perception (GO:0050908) | 4.01696520 |
| 23 | folic acid transport (GO:0015884) | 4.00769216 |
| 24 | folic acid metabolic process (GO:0046655) | 3.99940373 |
| 25 | positive regulation of mitochondrial fission (GO:0090141) | 3.99871617 |
| 26 | regulation of cilium movement (GO:0003352) | 3.99172843 |
| 27 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.94877502 |
| 28 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.94877502 |
| 29 | NADH dehydrogenase complex assembly (GO:0010257) | 3.94877502 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.91843523 |
| 31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.91843523 |
| 32 | epithelial cilium movement (GO:0003351) | 3.91396167 |
| 33 | ubiquinone biosynthetic process (GO:0006744) | 3.90684032 |
| 34 | response to pheromone (GO:0019236) | 3.85426228 |
| 35 | translational elongation (GO:0006414) | 3.79615564 |
| 36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.71007143 |
| 37 | cilium movement (GO:0003341) | 3.70987634 |
| 38 | regulation of G0 to G1 transition (GO:0070316) | 3.67552095 |
| 39 | axonemal dynein complex assembly (GO:0070286) | 3.67048169 |
| 40 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.63552455 |
| 41 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.61583594 |
| 42 | protein polyglutamylation (GO:0018095) | 3.59905413 |
| 43 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.58169645 |
| 44 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.56826780 |
| 45 | protein targeting to ER (GO:0045047) | 3.52892158 |
| 46 | respiratory chain complex IV assembly (GO:0008535) | 3.49981833 |
| 47 | cotranslational protein targeting to membrane (GO:0006613) | 3.49445629 |
| 48 | ubiquinone metabolic process (GO:0006743) | 3.48856465 |
| 49 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.47773224 |
| 50 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.47522773 |
| 51 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.46169959 |
| 52 | termination of RNA polymerase I transcription (GO:0006363) | 3.45106142 |
| 53 | cellular protein complex disassembly (GO:0043624) | 3.44379791 |
| 54 | viral life cycle (GO:0019058) | 3.41232665 |
| 55 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 3.39615524 |
| 56 | platelet dense granule organization (GO:0060155) | 3.38475466 |
| 57 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.38144664 |
| 58 | ATP synthesis coupled proton transport (GO:0015986) | 3.38144664 |
| 59 | protein localization to endoplasmic reticulum (GO:0070972) | 3.38011422 |
| 60 | kynurenine metabolic process (GO:0070189) | 3.37960271 |
| 61 | negative regulation of ligase activity (GO:0051352) | 3.37740212 |
| 62 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.37740212 |
| 63 | rRNA processing (GO:0006364) | 3.36961801 |
| 64 | rRNA modification (GO:0000154) | 3.35675764 |
| 65 | translation (GO:0006412) | 3.35511821 |
| 66 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.35173901 |
| 67 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.33757805 |
| 68 | transcription from RNA polymerase I promoter (GO:0006360) | 3.33608342 |
| 69 | ribosomal small subunit assembly (GO:0000028) | 3.31050026 |
| 70 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.30270554 |
| 71 | cellular ketone body metabolic process (GO:0046950) | 3.30247851 |
| 72 | cytochrome complex assembly (GO:0017004) | 3.29967483 |
| 73 | mitotic metaphase plate congression (GO:0007080) | 3.28278627 |
| 74 | cornea development in camera-type eye (GO:0061303) | 3.26581855 |
| 75 | rRNA metabolic process (GO:0016072) | 3.24082861 |
| 76 | 7-methylguanosine mRNA capping (GO:0006370) | 3.21531949 |
| 77 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.21385826 |
| 78 | protein K11-linked deubiquitination (GO:0035871) | 3.20482470 |
| 79 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.19918295 |
| 80 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.18053055 |
| 81 | response to misfolded protein (GO:0051788) | 3.17661491 |
| 82 | positive regulation of ligase activity (GO:0051351) | 3.17574864 |
| 83 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.16792468 |
| 84 | protein-cofactor linkage (GO:0018065) | 3.16640195 |
| 85 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.14568832 |
| 86 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.14568832 |
| 87 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.14568832 |
| 88 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.13143367 |
| 89 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.13143367 |
| 90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.12102228 |
| 91 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.12102228 |
| 92 | indolalkylamine metabolic process (GO:0006586) | 3.11401113 |
| 93 | blastocyst development (GO:0001824) | 3.10221122 |
| 94 | pseudouridine synthesis (GO:0001522) | 3.08710709 |
| 95 | estrogen biosynthetic process (GO:0006703) | 3.07552053 |
| 96 | RNA capping (GO:0036260) | 3.07173922 |
| 97 | 7-methylguanosine RNA capping (GO:0009452) | 3.07173922 |
| 98 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.06820543 |
| 99 | regulation of spindle organization (GO:0090224) | 3.05637320 |
| 100 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.05616299 |
| 101 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.05586587 |
| 102 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.04498345 |
| 103 | quinone biosynthetic process (GO:1901663) | 3.04114796 |
| 104 | GDP-mannose metabolic process (GO:0019673) | 3.04085395 |
| 105 | regulation of histone phosphorylation (GO:0033127) | 3.03936771 |
| 106 | chondrocyte proliferation (GO:0035988) | 3.02645868 |
| 107 | regulation of translational termination (GO:0006449) | 3.01825630 |
| 108 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.01207169 |
| 109 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.01207169 |
| 110 | retinal cone cell development (GO:0046549) | 3.00825272 |
| 111 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.00400672 |
| 112 | C-terminal protein lipidation (GO:0006501) | 2.98647879 |
| 113 | regulation of integrin-mediated signaling pathway (GO:2001044) | 2.98475067 |
| 114 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.97580357 |
| 115 | ketone body metabolic process (GO:1902224) | 2.96513165 |
| 116 | protein deneddylation (GO:0000338) | 2.96418604 |
| 117 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.96031318 |
| 118 | cell cycle G1/S phase transition (GO:0044843) | 2.96031318 |
| 119 | positive regulation of prostaglandin secretion (GO:0032308) | 2.93692302 |
| 120 | skin morphogenesis (GO:0043589) | 2.92587871 |
| 121 | cellular component biogenesis (GO:0044085) | 2.92364893 |
| 122 | tRNA modification (GO:0006400) | 2.91853528 |
| 123 | regulation of mitochondrial fission (GO:0090140) | 2.91344052 |
| 124 | protein complex disassembly (GO:0043241) | 2.89683164 |
| 125 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.89540079 |
| 126 | DNA replication checkpoint (GO:0000076) | 2.88593047 |
| 127 | histone-serine phosphorylation (GO:0035404) | 2.87803069 |
| 128 | spliceosomal snRNP assembly (GO:0000387) | 2.87066087 |
| 129 | indole-containing compound catabolic process (GO:0042436) | 2.86245382 |
| 130 | indolalkylamine catabolic process (GO:0046218) | 2.86245382 |
| 131 | tryptophan catabolic process (GO:0006569) | 2.86245382 |
| 132 | cellular biogenic amine catabolic process (GO:0042402) | 2.86188184 |
| 133 | amine catabolic process (GO:0009310) | 2.86188184 |
| 134 | C-terminal protein amino acid modification (GO:0018410) | 2.85464388 |
| 135 | peptidyl-histidine modification (GO:0018202) | 2.85170774 |
| 136 | tRNA processing (GO:0008033) | 2.83138672 |
| 137 | chaperone-mediated protein transport (GO:0072321) | 2.82999096 |
| 138 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.82824725 |
| 139 | sperm motility (GO:0030317) | 2.82528802 |
| 140 | cellular response to ATP (GO:0071318) | 2.81993615 |
| 141 | regulation of ligase activity (GO:0051340) | 2.80681968 |
| 142 | wound healing, spreading of epidermal cells (GO:0035313) | 2.80334593 |
| 143 | piRNA metabolic process (GO:0034587) | 2.80081994 |
| 144 | regulation of translation in response to stress (GO:0043555) | 2.79884418 |
| 145 | cilium morphogenesis (GO:0060271) | 2.79765355 |
| 146 | positive regulation of cell cycle arrest (GO:0071158) | 2.78231797 |
| 147 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.78190078 |
| 148 | macromolecular complex disassembly (GO:0032984) | 2.77927831 |
| 149 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.77765356 |
| 150 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.76206965 |
| 151 | neural tube formation (GO:0001841) | 2.75456138 |
| 152 | detection of chemical stimulus involved in sensory perception (GO:0050907) | 2.73429189 |
| 153 | motile cilium assembly (GO:0044458) | 2.72965228 |
| 154 | multicellular organism reproduction (GO:0032504) | 2.72942259 |
| 155 | regulation of protein heterodimerization activity (GO:0043497) | 2.72215395 |
| 156 | synaptic transmission, cholinergic (GO:0007271) | 2.72164918 |
| 157 | mitotic nuclear envelope disassembly (GO:0007077) | 2.71539688 |
| 158 | photoreceptor cell maintenance (GO:0045494) | 2.71437448 |
| 159 | regulation of microtubule-based movement (GO:0060632) | 2.70695001 |
| 160 | electron transport chain (GO:0022900) | 2.70684078 |
| 161 | iron-sulfur cluster assembly (GO:0016226) | 2.70379991 |
| 162 | metallo-sulfur cluster assembly (GO:0031163) | 2.70379991 |
| 163 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.70036257 |
| 164 | GTP biosynthetic process (GO:0006183) | 2.66123144 |
| 165 | regulation of mitotic spindle organization (GO:0060236) | 2.65527934 |
| 166 | membrane disassembly (GO:0030397) | 2.64647269 |
| 167 | nuclear envelope disassembly (GO:0051081) | 2.64647269 |
| 168 | purine nucleotide salvage (GO:0032261) | 2.64496857 |
| 169 | photoreceptor cell development (GO:0042461) | 2.64026927 |
| 170 | nonmotile primary cilium assembly (GO:0035058) | 2.63827535 |
| 171 | peptidyl-proline hydroxylation (GO:0019511) | 2.63200704 |
| 172 | membrane budding (GO:0006900) | 2.63148347 |
| 173 | respiratory electron transport chain (GO:0022904) | 2.63119624 |
| 174 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.61945652 |
| 175 | GMP metabolic process (GO:0046037) | 2.60630993 |
| 176 | tryptophan metabolic process (GO:0006568) | 2.60496117 |
| 177 | retinal rod cell development (GO:0046548) | 2.58805835 |
| 178 | DNA methylation involved in gamete generation (GO:0043046) | 2.58700414 |
| 179 | cullin deneddylation (GO:0010388) | 2.58315921 |
| 180 | base-excision repair, AP site formation (GO:0006285) | 2.57826984 |
| 181 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.57274684 |
| 182 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.56060307 |
| 183 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.56060307 |
| 184 | cilium organization (GO:0044782) | 2.55473098 |
| 185 | NAD biosynthetic process (GO:0009435) | 2.54895002 |
| 186 | GPI anchor metabolic process (GO:0006505) | 2.53217585 |
| 187 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 2.53083449 |
| 188 | protein localization to cilium (GO:0061512) | 2.51191872 |
| 189 | fucose catabolic process (GO:0019317) | 2.50415231 |
| 190 | L-fucose metabolic process (GO:0042354) | 2.50415231 |
| 191 | L-fucose catabolic process (GO:0042355) | 2.50415231 |
| 192 | negative regulation of telomere maintenance (GO:0032205) | 2.48976019 |
| 193 | tachykinin receptor signaling pathway (GO:0007217) | 2.47271438 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.02456169 |
| 2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.72275107 |
| 3 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.46505566 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.45268809 |
| 5 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.25232016 |
| 6 | VDR_22108803_ChIP-Seq_LS180_Human | 3.21333118 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.10131408 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.06435923 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.95262206 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.94456569 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.90760581 |
| 12 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.79991190 |
| 13 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.75023466 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.68779313 |
| 15 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.59448799 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.48082701 |
| 17 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.31486076 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.17931741 |
| 19 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.14698707 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.14108077 |
| 21 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.07330313 |
| 22 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.06084641 |
| 23 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.05520849 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.03991242 |
| 25 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.03904762 |
| 26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.02196063 |
| 27 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.97594764 |
| 28 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.97007168 |
| 29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.96503065 |
| 30 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.94568971 |
| 31 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.94556876 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.90953042 |
| 33 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.90096352 |
| 34 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.88760094 |
| 35 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.87645053 |
| 36 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.84075182 |
| 37 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.83288315 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.80724387 |
| 39 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.80648379 |
| 40 | ERA_21632823_ChIP-Seq_H3396_Human | 1.79769782 |
| 41 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.77817519 |
| 42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.71325976 |
| 43 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.69847889 |
| 44 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.69796111 |
| 45 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.69028364 |
| 46 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.68891353 |
| 47 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.68326707 |
| 48 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.64734162 |
| 49 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.63937633 |
| 50 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.63768216 |
| 51 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.63592793 |
| 52 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.63590696 |
| 53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.63222110 |
| 54 | ATF3_27146783_Chip-Seq_COLON_Human | 1.60653925 |
| 55 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.60201942 |
| 56 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.59878481 |
| 57 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.56530107 |
| 58 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.55093440 |
| 59 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.55055762 |
| 60 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.54257879 |
| 61 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.53244359 |
| 62 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.52335373 |
| 63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.51595562 |
| 64 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.50425355 |
| 65 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.48322208 |
| 66 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.47008111 |
| 67 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.46048344 |
| 68 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.46016576 |
| 69 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.45655179 |
| 70 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.45627456 |
| 71 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.44604917 |
| 72 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.44170258 |
| 73 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.42819277 |
| 74 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.42696436 |
| 75 | * MYC_19829295_ChIP-Seq_ESCs_Human | 1.42263064 |
| 76 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.42258841 |
| 77 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.42222252 |
| 78 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.41650112 |
| 79 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.41435128 |
| 80 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.40847748 |
| 81 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.40406367 |
| 82 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.40358450 |
| 83 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.36416211 |
| 84 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.33845209 |
| 85 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.33449672 |
| 86 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.32693626 |
| 87 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.32356979 |
| 88 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.32286997 |
| 89 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.32055540 |
| 90 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.31644537 |
| 91 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.29910687 |
| 92 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.28959853 |
| 93 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.27391291 |
| 94 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.26366164 |
| 95 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.26157704 |
| 96 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.25145948 |
| 97 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.24372037 |
| 98 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.24372037 |
| 99 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.24273045 |
| 100 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.23921215 |
| 101 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.23710261 |
| 102 | NCOR_22424771_ChIP-Seq_293T_Human | 1.23663586 |
| 103 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.23388813 |
| 104 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22609386 |
| 105 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.22285652 |
| 106 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.21924445 |
| 107 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.21887277 |
| 108 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.21848210 |
| 109 | AR_20517297_ChIP-Seq_VCAP_Human | 1.21504544 |
| 110 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20210004 |
| 111 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.20135935 |
| 112 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.19533764 |
| 113 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.18819441 |
| 114 | P68_20966046_ChIP-Seq_HELA_Human | 1.18546490 |
| 115 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.18174831 |
| 116 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.17804209 |
| 117 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.17389869 |
| 118 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.17240676 |
| 119 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.17240676 |
| 120 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.17072675 |
| 121 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.16712154 |
| 122 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16559552 |
| 123 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.15857275 |
| 124 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.15363841 |
| 125 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.14489178 |
| 126 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.14489178 |
| 127 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.13794921 |
| 128 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.13372107 |
| 129 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.13368601 |
| 130 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.12482743 |
| 131 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.11995975 |
| 132 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.10087821 |
| 133 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.09684204 |
| 134 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.09296474 |
| 135 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.08757027 |
| 136 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.08324258 |
| 137 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.08094585 |
| 138 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.07889239 |
| 139 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.07603493 |
| 140 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.07111026 |
| 141 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.07023426 |
| 142 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.06266096 |
| 143 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06012276 |
| 144 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.05450764 |
| 145 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.05278093 |
| 146 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.05227006 |
| 147 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.04712718 |
| 148 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.04372998 |
| 149 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.04005528 |
| 150 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.03995572 |
| 151 | P300_27268052_Chip-Seq_Bcells_Human | 1.03635567 |
| 152 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.02367887 |
| 153 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.02259005 |
| 154 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.01765116 |
| 155 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.01602873 |
| 156 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.01489220 |
| 157 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01130807 |
| 158 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.00469926 |
| 159 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.00469926 |
| 160 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.00427591 |
| 161 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.00410928 |
| 162 | EWS_26573619_Chip-Seq_HEK293_Human | 1.00234085 |
| 163 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.99949358 |
| 164 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.99508873 |
| 165 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99121349 |
| 166 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.98745271 |
| 167 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.98044872 |
| 168 | FUS_26573619_Chip-Seq_HEK293_Human | 0.96954019 |
| 169 | MYC_22102868_ChIP-Seq_BL_Human | 0.96567273 |
| 170 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96294673 |
| 171 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.96155932 |
| 172 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.94378400 |
| 173 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.94316653 |
| 174 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.93632980 |
| 175 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.93328892 |
| 176 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.93040012 |
| 177 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.92790010 |
| 178 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.91092184 |
| 179 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.91044540 |
| 180 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90429222 |
| 181 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.90348964 |
| 182 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.90093548 |
| 183 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.89214933 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.54816248 |
| 2 | MP0008438_abnormal_cutaneous_collagen | 4.14053580 |
| 3 | MP0003136_yellow_coat_color | 3.46091672 |
| 4 | MP0005275_abnormal_skin_tensile | 3.43712631 |
| 5 | MP0003705_abnormal_hypodermis_morpholog | 3.43174321 |
| 6 | MP0005084_abnormal_gallbladder_morpholo | 3.35530734 |
| 7 | MP0008875_abnormal_xenobiotic_pharmacok | 3.16540121 |
| 8 | MP0010352_gastrointestinal_tract_polyps | 2.75711154 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.74504193 |
| 10 | MP0004957_abnormal_blastocyst_morpholog | 2.74502926 |
| 11 | MP0005551_abnormal_eye_electrophysiolog | 2.57601821 |
| 12 | MP0001542_abnormal_bone_strength | 2.56201652 |
| 13 | MP0003195_calcinosis | 2.41091011 |
| 14 | MP0000372_irregular_coat_pigmentation | 2.37570238 |
| 15 | MP0002638_abnormal_pupillary_reflex | 2.30971623 |
| 16 | MP0002736_abnormal_nociception_after | 2.26065479 |
| 17 | MP0003111_abnormal_nucleus_morphology | 2.25993850 |
| 18 | MP0003279_aneurysm | 2.25108873 |
| 19 | MP0001986_abnormal_taste_sensitivity | 2.22848654 |
| 20 | MP0002653_abnormal_ependyma_morphology | 2.18107483 |
| 21 | MP0005253_abnormal_eye_physiology | 2.08316625 |
| 22 | MP0003566_abnormal_cell_adhesion | 2.05946798 |
| 23 | MP0001905_abnormal_dopamine_level | 2.05346712 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 2.04679967 |
| 25 | MP0002837_dystrophic_cardiac_calcinosis | 2.03397824 |
| 26 | MP0005503_abnormal_tendon_morphology | 2.02111152 |
| 27 | MP0005257_abnormal_intraocular_pressure | 1.99660249 |
| 28 | MP0003077_abnormal_cell_cycle | 1.98737382 |
| 29 | MP0000750_abnormal_muscle_regeneration | 1.96104749 |
| 30 | MP0005023_abnormal_wound_healing | 1.95919600 |
| 31 | MP0005451_abnormal_body_composition | 1.94935028 |
| 32 | MP0005171_absent_coat_pigmentation | 1.90081345 |
| 33 | MP0002796_impaired_skin_barrier | 1.89673296 |
| 34 | MP0003011_delayed_dark_adaptation | 1.89347234 |
| 35 | MP0005423_abnormal_somatic_nervous | 1.85055484 |
| 36 | MP0009333_abnormal_splenocyte_physiolog | 1.83925997 |
| 37 | MP0003941_abnormal_skin_development | 1.83746451 |
| 38 | MP0008932_abnormal_embryonic_tissue | 1.83197153 |
| 39 | MP0003718_maternal_effect | 1.82818348 |
| 40 | MP0001529_abnormal_vocalization | 1.82405612 |
| 41 | MP0005410_abnormal_fertilization | 1.81825236 |
| 42 | MP0010307_abnormal_tumor_latency | 1.79968226 |
| 43 | MP0005645_abnormal_hypothalamus_physiol | 1.78480440 |
| 44 | MP0002060_abnormal_skin_morphology | 1.75967425 |
| 45 | MP0010030_abnormal_orbit_morphology | 1.73725918 |
| 46 | MP0002877_abnormal_melanocyte_morpholog | 1.72073165 |
| 47 | MP0000858_altered_metastatic_potential | 1.71808379 |
| 48 | MP0006292_abnormal_olfactory_placode | 1.71529017 |
| 49 | MP0009046_muscle_twitch | 1.70498202 |
| 50 | MP0003646_muscle_fatigue | 1.69798281 |
| 51 | MP0008872_abnormal_physiological_respon | 1.68379233 |
| 52 | MP0002102_abnormal_ear_morphology | 1.67481532 |
| 53 | MP0002876_abnormal_thyroid_physiology | 1.66550104 |
| 54 | MP0001958_emphysema | 1.64470547 |
| 55 | MP0005623_abnormal_meninges_morphology | 1.64160623 |
| 56 | MP0002928_abnormal_bile_duct | 1.63173435 |
| 57 | MP0002396_abnormal_hematopoietic_system | 1.62245715 |
| 58 | MP0008007_abnormal_cellular_replicative | 1.61441662 |
| 59 | MP0004133_heterotaxia | 1.61284580 |
| 60 | MP0005174_abnormal_tail_pigmentation | 1.58951124 |
| 61 | MP0005083_abnormal_biliary_tract | 1.58444592 |
| 62 | MP0005379_endocrine/exocrine_gland_phen | 1.57435558 |
| 63 | MP0005501_abnormal_skin_physiology | 1.56001635 |
| 64 | MP0006276_abnormal_autonomic_nervous | 1.55229885 |
| 65 | MP0006054_spinal_hemorrhage | 1.53181897 |
| 66 | MP0005377_hearing/vestibular/ear_phenot | 1.51744811 |
| 67 | MP0003878_abnormal_ear_physiology | 1.51744811 |
| 68 | MP0010386_abnormal_urinary_bladder | 1.47196468 |
| 69 | MP0000350_abnormal_cell_proliferation | 1.47195986 |
| 70 | MP0001730_embryonic_growth_arrest | 1.46842281 |
| 71 | MP0009745_abnormal_behavioral_response | 1.45927355 |
| 72 | MP0004142_abnormal_muscle_tone | 1.45588826 |
| 73 | MP0010094_abnormal_chromosome_stability | 1.44537013 |
| 74 | MP0001243_abnormal_dermal_layer | 1.44046650 |
| 75 | MP0008260_abnormal_autophagy | 1.41361107 |
| 76 | MP0003786_premature_aging | 1.40220075 |
| 77 | MP0004043_abnormal_pH_regulation | 1.40072815 |
| 78 | MP0000358_abnormal_cell_content/ | 1.39753765 |
| 79 | MP0009840_abnormal_foam_cell | 1.38344701 |
| 80 | MP0005508_abnormal_skeleton_morphology | 1.38194555 |
| 81 | MP0010234_abnormal_vibrissa_follicle | 1.35138998 |
| 82 | MP0003880_abnormal_central_pattern | 1.33095895 |
| 83 | MP0005646_abnormal_pituitary_gland | 1.32676273 |
| 84 | MP0000490_abnormal_crypts_of | 1.28008773 |
| 85 | MP0002572_abnormal_emotion/affect_behav | 1.26226656 |
| 86 | MP0003091_abnormal_cell_migration | 1.25574831 |
| 87 | MP0002272_abnormal_nervous_system | 1.25347348 |
| 88 | MP0006036_abnormal_mitochondrial_physio | 1.25201473 |
| 89 | MP0005389_reproductive_system_phenotype | 1.24366678 |
| 90 | MP0008877_abnormal_DNA_methylation | 1.22306825 |
| 91 | MP0001485_abnormal_pinna_reflex | 1.22154962 |
| 92 | MP0001970_abnormal_pain_threshold | 1.19998506 |
| 93 | MP0003950_abnormal_plasma_membrane | 1.18820148 |
| 94 | MP0003806_abnormal_nucleotide_metabolis | 1.17062879 |
| 95 | MP0002735_abnormal_chemical_nociception | 1.16495378 |
| 96 | MP0004947_skin_inflammation | 1.15910443 |
| 97 | MP0001501_abnormal_sleep_pattern | 1.15909674 |
| 98 | MP0000733_abnormal_muscle_development | 1.13245228 |
| 99 | MP0002909_abnormal_adrenal_gland | 1.11824616 |
| 100 | MP0008961_abnormal_basal_metabolism | 1.10934781 |
| 101 | MP0002557_abnormal_social/conspecific_i | 1.10108575 |
| 102 | MP0003186_abnormal_redox_activity | 1.09916110 |
| 103 | MP0001545_abnormal_hematopoietic_system | 1.07906273 |
| 104 | MP0005397_hematopoietic_system_phenotyp | 1.07906273 |
| 105 | MP0001764_abnormal_homeostasis | 1.07257586 |
| 106 | MP0003448_altered_tumor_morphology | 1.06910517 |
| 107 | MP0000026_abnormal_inner_ear | 1.06564906 |
| 108 | MP0005076_abnormal_cell_differentiation | 1.04779657 |
| 109 | MP0002733_abnormal_thermal_nociception | 1.04416830 |
| 110 | MP0005332_abnormal_amino_acid | 1.03437501 |
| 111 | MP0004808_abnormal_hematopoietic_stem | 1.03431924 |
| 112 | MP0000538_abnormal_urinary_bladder | 1.03209110 |
| 113 | MP0005390_skeleton_phenotype | 1.02987873 |
| 114 | MP0004147_increased_porphyrin_level | 1.02063084 |
| 115 | MP0004742_abnormal_vestibular_system | 1.01949733 |
| 116 | MP0009379_abnormal_foot_pigmentation | 1.01857932 |
| 117 | MP0009384_cardiac_valve_regurgitation | 1.01773638 |
| 118 | MP0002751_abnormal_autonomic_nervous | 1.01586492 |
| 119 | MP0001216_abnormal_epidermal_layer | 1.00520748 |
| 120 | MP0008789_abnormal_olfactory_epithelium | 1.00460045 |
| 121 | MP0002080_prenatal_lethality | 0.99837207 |
| 122 | MP0004885_abnormal_endolymph | 0.99671437 |
| 123 | MP0005195_abnormal_posterior_eye | 0.98241965 |
| 124 | MP0002163_abnormal_gland_morphology | 0.97604286 |
| 125 | MP0005621_abnormal_cell_physiology | 0.96832773 |
| 126 | MP0005058_abnormal_lysosome_morphology | 0.96643426 |
| 127 | MP0005395_other_phenotype | 0.96586907 |
| 128 | MP0001919_abnormal_reproductive_system | 0.96376443 |
| 129 | MP0010771_integument_phenotype | 0.94325108 |
| 130 | MP0005380_embryogenesis_phenotype | 0.94087569 |
| 131 | MP0001672_abnormal_embryogenesis/_devel | 0.94087569 |
| 132 | MP0003698_abnormal_male_reproductive | 0.93985147 |
| 133 | MP0002938_white_spotting | 0.93227259 |
| 134 | MP0001697_abnormal_embryo_size | 0.92797752 |
| 135 | MP0001299_abnormal_eye_distance/ | 0.92323054 |
| 136 | MP0005636_abnormal_mineral_homeostasis | 0.91992562 |
| 137 | MP0001533_abnormal_skeleton_physiology | 0.91515455 |
| 138 | MP0000427_abnormal_hair_cycle | 0.91316270 |
| 139 | MP0003787_abnormal_imprinting | 0.90871710 |
| 140 | MP0001984_abnormal_olfaction | 0.89552975 |
| 141 | MP0002064_seizures | 0.89151922 |
| 142 | MP0000631_abnormal_neuroendocrine_gland | 0.88954090 |
| 143 | MP0002229_neurodegeneration | 0.88633720 |
| 144 | MP0002019_abnormal_tumor_incidence | 0.88429415 |
| 145 | MP0002067_abnormal_sensory_capabilities | 0.87633207 |
| 146 | MP0008058_abnormal_DNA_repair | 0.87631814 |
| 147 | MP0002138_abnormal_hepatobiliary_system | 0.87397758 |
| 148 | MP0003436_decreased_susceptibility_to | 0.86498891 |
| 149 | MP0005365_abnormal_bile_salt | 0.86073789 |
| 150 | MP0001486_abnormal_startle_reflex | 0.85249975 |
| 151 | MP0001502_abnormal_circadian_rhythm | 0.85199047 |
| 152 | MP0006035_abnormal_mitochondrial_morpho | 0.84972745 |
| 153 | MP0003984_embryonic_growth_retardation | 0.82784666 |
| 154 | MP0003635_abnormal_synaptic_transmissio | 0.82577710 |
| 155 | MP0004858_abnormal_nervous_system | 0.82432427 |
| 156 | MP0002234_abnormal_pharynx_morphology | 0.81295385 |
| 157 | MP0005384_cellular_phenotype | 0.81276935 |
| 158 | MP0000647_abnormal_sebaceous_gland | 0.81143093 |
| 159 | MP0002210_abnormal_sex_determination | 0.80939441 |
| 160 | MP0001756_abnormal_urination | 0.80508666 |
| 161 | MP0002088_abnormal_embryonic_growth/wei | 0.80415014 |
| 162 | MP0009931_abnormal_skin_appearance | 0.79940601 |
| 163 | MP0004019_abnormal_vitamin_homeostasis | 0.79260869 |
| 164 | MP0002160_abnormal_reproductive_system | 0.79109812 |
| 165 | MP0001963_abnormal_hearing_physiology | 0.79026442 |
| 166 | MP0002752_abnormal_somatic_nervous | 0.78583659 |
| 167 | MP0000428_abnormal_craniofacial_morphol | 0.78150803 |
| 168 | MP0001324_abnormal_eye_pigmentation | 0.77957102 |
| 169 | MP0002693_abnormal_pancreas_physiology | 0.77796082 |
| 170 | MP0000627_abnormal_mammary_gland | 0.77624095 |
| 171 | MP0002295_abnormal_pulmonary_circulatio | 0.77504970 |
| 172 | MP0005386_behavior/neurological_phenoty | 0.77466530 |
| 173 | MP0004924_abnormal_behavior | 0.77466530 |
| 174 | MP0000230_abnormal_systemic_arterial | 0.77098495 |
| 175 | MP0003879_abnormal_hair_cell | 0.76102645 |
| 176 | MP0001929_abnormal_gametogenesis | 0.75900270 |
| 177 | MP0001727_abnormal_embryo_implantation | 0.73660711 |
| 178 | MP0002086_abnormal_extraembryonic_tissu | 0.72618768 |
| 179 | MP0004185_abnormal_adipocyte_glucose | 0.71092357 |
| 180 | MP0004272_abnormal_basement_membrane | 0.70843595 |
| 181 | MP0000313_abnormal_cell_death | 0.69791540 |
| 182 | MP0003453_abnormal_keratinocyte_physiol | 0.69765569 |
| 183 | MP0009250_abnormal_appendicular_skeleto | 0.69746498 |
| 184 | MP0003567_abnormal_fetal_cardiomyocyte | 0.68780268 |
| 185 | MP0002132_abnormal_respiratory_system | 0.67116935 |
| 186 | MP0000377_abnormal_hair_follicle | 0.66264466 |
| 187 | MP0003795_abnormal_bone_structure | 0.66031064 |
| 188 | MP0002085_abnormal_embryonic_tissue | 0.65214994 |
| 189 | MP0004197_abnormal_fetal_growth/weight/ | 0.63935102 |
| 190 | MP0003221_abnormal_cardiomyocyte_apopto | 0.63201730 |
| 191 | MP0000747_muscle_weakness | 0.62821980 |
| 192 | MP0002405_respiratory_system_inflammati | 0.62615354 |
| 193 | MP0009053_abnormal_anal_canal | 0.62204544 |
| 194 | MP0002089_abnormal_postnatal_growth/wei | 0.60215204 |
| 195 | MP0000013_abnormal_adipose_tissue | 0.58145221 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Premature rupture of membranes (HP:0001788) | 6.80938415 |
| 2 | Protrusio acetabuli (HP:0003179) | 5.82218882 |
| 3 | Congenital stationary night blindness (HP:0007642) | 4.13588012 |
| 4 | Abnormality of midbrain morphology (HP:0002418) | 3.94659024 |
| 5 | Molar tooth sign on MRI (HP:0002419) | 3.94659024 |
| 6 | Pancreatic fibrosis (HP:0100732) | 3.79002024 |
| 7 | Cervical subluxation (HP:0003308) | 3.78037965 |
| 8 | Absent/shortened dynein arms (HP:0200106) | 3.77644559 |
| 9 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.77644559 |
| 10 | Vertebral compression fractures (HP:0002953) | 3.71265226 |
| 11 | Pancreatic cysts (HP:0001737) | 3.71208789 |
| 12 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.68591837 |
| 13 | Mitochondrial inheritance (HP:0001427) | 3.67981073 |
| 14 | Ankle contracture (HP:0006466) | 3.64307095 |
| 15 | Acute necrotizing encephalopathy (HP:0006965) | 3.60045889 |
| 16 | Carpal bone hypoplasia (HP:0001498) | 3.50409613 |
| 17 | True hermaphroditism (HP:0010459) | 3.47110072 |
| 18 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.43741054 |
| 19 | Breast hypoplasia (HP:0003187) | 3.41270797 |
| 20 | Attenuation of retinal blood vessels (HP:0007843) | 3.41235702 |
| 21 | Peritonitis (HP:0002586) | 3.35123596 |
| 22 | Short nail (HP:0001799) | 3.32758773 |
| 23 | Osteolytic defects of the hand bones (HP:0009699) | 3.32708646 |
| 24 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 3.32708646 |
| 25 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.30802745 |
| 26 | Increased CSF lactate (HP:0002490) | 3.30634228 |
| 27 | Rough bone trabeculation (HP:0100670) | 3.30135504 |
| 28 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.29702383 |
| 29 | Nephronophthisis (HP:0000090) | 3.29111510 |
| 30 | Hepatocellular necrosis (HP:0001404) | 3.27406500 |
| 31 | Soft skin (HP:0000977) | 3.21598364 |
| 32 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.21214885 |
| 33 | Abnormality of the umbilical cord (HP:0010881) | 3.20055497 |
| 34 | Acute encephalopathy (HP:0006846) | 3.15934932 |
| 35 | Lipid accumulation in hepatocytes (HP:0006561) | 3.15716359 |
| 36 | Polydipsia (HP:0001959) | 3.13863178 |
| 37 | Abnormal drinking behavior (HP:0030082) | 3.13863178 |
| 38 | Polyuria (HP:0000103) | 3.13361542 |
| 39 | Trismus (HP:0000211) | 3.07438028 |
| 40 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.07267495 |
| 41 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.06663116 |
| 42 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.06663116 |
| 43 | Multiple enchondromatosis (HP:0005701) | 2.96968263 |
| 44 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.95611958 |
| 45 | Hepatic necrosis (HP:0002605) | 2.94922296 |
| 46 | Genu recurvatum (HP:0002816) | 2.92945212 |
| 47 | Progressive macrocephaly (HP:0004481) | 2.91052358 |
| 48 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.90441533 |
| 49 | Increased hepatocellular lipid droplets (HP:0006565) | 2.89689099 |
| 50 | Dilatation of the ascending aorta (HP:0005111) | 2.85811953 |
| 51 | Renal Fanconi syndrome (HP:0001994) | 2.84026602 |
| 52 | Abnormal ciliary motility (HP:0012262) | 2.83550657 |
| 53 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.80193306 |
| 54 | Chronic hepatic failure (HP:0100626) | 2.78522290 |
| 55 | Decreased central vision (HP:0007663) | 2.74205502 |
| 56 | Biconcave vertebral bodies (HP:0004586) | 2.72927185 |
| 57 | Abnormality of the renal medulla (HP:0100957) | 2.72456109 |
| 58 | Type II lissencephaly (HP:0007260) | 2.70982234 |
| 59 | Difficulty climbing stairs (HP:0003551) | 2.70915221 |
| 60 | Thoracolumbar scoliosis (HP:0002944) | 2.70517942 |
| 61 | Atrophic scars (HP:0001075) | 2.69498045 |
| 62 | Achilles tendon contracture (HP:0001771) | 2.68681096 |
| 63 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.67488346 |
| 64 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.64638228 |
| 65 | Abnormality of renal resorption (HP:0011038) | 2.61176876 |
| 66 | Optic disc pallor (HP:0000543) | 2.59951698 |
| 67 | Shallow orbits (HP:0000586) | 2.54970880 |
| 68 | Fragile skin (HP:0001030) | 2.54834095 |
| 69 | Increased connective tissue (HP:0009025) | 2.52743538 |
| 70 | Abnormal urine output (HP:0012590) | 2.51409792 |
| 71 | Pustule (HP:0200039) | 2.51064365 |
| 72 | 3-Methylglutaconic aciduria (HP:0003535) | 2.50699103 |
| 73 | Mesangial abnormality (HP:0001966) | 2.49616204 |
| 74 | Birth length less than 3rd percentile (HP:0003561) | 2.49440738 |
| 75 | Entropion (HP:0000621) | 2.48381419 |
| 76 | Beaking of vertebral bodies (HP:0004568) | 2.48332002 |
| 77 | Microretrognathia (HP:0000308) | 2.48326000 |
| 78 | Abnormal trabecular bone morphology (HP:0100671) | 2.46286306 |
| 79 | Sparse lateral eyebrow (HP:0005338) | 2.45686205 |
| 80 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.44774233 |
| 81 | Cerebral hypomyelination (HP:0006808) | 2.44757872 |
| 82 | Cystic liver disease (HP:0006706) | 2.41638602 |
| 83 | Medial flaring of the eyebrow (HP:0010747) | 2.41620434 |
| 84 | Increased serum lactate (HP:0002151) | 2.40452056 |
| 85 | Wormian bones (HP:0002645) | 2.38777682 |
| 86 | Abnormal delivery (HP:0001787) | 2.37443917 |
| 87 | Abnormal number of erythroid precursors (HP:0012131) | 2.36794872 |
| 88 | Sparse eyelashes (HP:0000653) | 2.35654083 |
| 89 | Type 2 muscle fiber atrophy (HP:0003554) | 2.32903995 |
| 90 | Lactic acidosis (HP:0003128) | 2.32633764 |
| 91 | Tubular atrophy (HP:0000092) | 2.32144916 |
| 92 | Cerebellar dysplasia (HP:0007033) | 2.29230128 |
| 93 | Distal arthrogryposis (HP:0005684) | 2.27474782 |
| 94 | Abnormality of the Achilles tendon (HP:0005109) | 2.26206890 |
| 95 | Abnormal biliary tract physiology (HP:0012439) | 2.25795717 |
| 96 | Bile duct proliferation (HP:0001408) | 2.25795717 |
| 97 | Rhinitis (HP:0012384) | 2.25342304 |
| 98 | Increased intramyocellular lipid droplets (HP:0012240) | 2.24868266 |
| 99 | Amelogenesis imperfecta (HP:0000705) | 2.24596165 |
| 100 | Aortic aneurysm (HP:0004942) | 2.23763223 |
| 101 | Abnormality of the acetabulum (HP:0003170) | 2.23293190 |
| 102 | Glossoptosis (HP:0000162) | 2.22433144 |
| 103 | Sclerocornea (HP:0000647) | 2.21582254 |
| 104 | Retinal dysplasia (HP:0007973) | 2.20503741 |
| 105 | Rib fusion (HP:0000902) | 2.20103480 |
| 106 | Abnormality of dental color (HP:0011073) | 2.20075387 |
| 107 | Wrist flexion contracture (HP:0001239) | 2.19819502 |
| 108 | Abnormality of renal excretion (HP:0011036) | 2.18759131 |
| 109 | Spinal rigidity (HP:0003306) | 2.18631719 |
| 110 | Degeneration of anterior horn cells (HP:0002398) | 2.18267596 |
| 111 | Abnormality of the anterior horn cell (HP:0006802) | 2.18267596 |
| 112 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.17992975 |
| 113 | Cerebral edema (HP:0002181) | 2.17743637 |
| 114 | Increased muscle lipid content (HP:0009058) | 2.15802138 |
| 115 | Ureteral duplication (HP:0000073) | 2.15760726 |
| 116 | Abnormality of dentin (HP:0010299) | 2.15656440 |
| 117 | Macrocytic anemia (HP:0001972) | 2.15067103 |
| 118 | Aortic dissection (HP:0002647) | 2.14567402 |
| 119 | Spinal cord compression (HP:0002176) | 2.13590480 |
| 120 | Elbow flexion contracture (HP:0002987) | 2.11101010 |
| 121 | Natal tooth (HP:0000695) | 2.10557683 |
| 122 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.08369176 |
| 123 | Secondary amenorrhea (HP:0000869) | 2.06492291 |
| 124 | Blue sclerae (HP:0000592) | 2.06031707 |
| 125 | Muscle fiber atrophy (HP:0100295) | 2.05780476 |
| 126 | Severe muscular hypotonia (HP:0006829) | 2.05522453 |
| 127 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.05384717 |
| 128 | Occipital encephalocele (HP:0002085) | 2.05087373 |
| 129 | Ileus (HP:0002595) | 2.04913263 |
| 130 | Chronic bronchitis (HP:0004469) | 2.04093734 |
| 131 | Abnormality of the renal cortex (HP:0011035) | 2.03825019 |
| 132 | Gait imbalance (HP:0002141) | 2.03784188 |
| 133 | Pendular nystagmus (HP:0012043) | 2.03687955 |
| 134 | Congenital hepatic fibrosis (HP:0002612) | 2.03379176 |
| 135 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.03305616 |
| 136 | Pallor (HP:0000980) | 2.01882545 |
| 137 | Breech presentation (HP:0001623) | 2.00996333 |
| 138 | Selective tooth agenesis (HP:0001592) | 2.00846997 |
| 139 | Ketosis (HP:0001946) | 2.00778676 |
| 140 | Abolished electroretinogram (ERG) (HP:0000550) | 2.00324120 |
| 141 | Areflexia of lower limbs (HP:0002522) | 1.99311872 |
| 142 | Abnormal cartilage morphology (HP:0002763) | 1.99208498 |
| 143 | Abnormality of macular pigmentation (HP:0008002) | 1.98023085 |
| 144 | Abnormal protein glycosylation (HP:0012346) | 1.97933797 |
| 145 | Abnormal glycosylation (HP:0012345) | 1.97933797 |
| 146 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.97933797 |
| 147 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.97933797 |
| 148 | Exertional dyspnea (HP:0002875) | 1.97507051 |
| 149 | Abnormality of the calcaneus (HP:0008364) | 1.96869912 |
| 150 | Large for gestational age (HP:0001520) | 1.96599404 |
| 151 | Abnormality of subcutaneous fat tissue (HP:0001001) | 1.96340431 |
| 152 | Slender long bone (HP:0003100) | 1.96204457 |
| 153 | Coxa vara (HP:0002812) | 1.95471726 |
| 154 | Chorioretinal atrophy (HP:0000533) | 1.94718557 |
| 155 | Progressive microcephaly (HP:0000253) | 1.94547603 |
| 156 | Anencephaly (HP:0002323) | 1.93980332 |
| 157 | Congenital primary aphakia (HP:0007707) | 1.93814449 |
| 158 | Cerebral aneurysm (HP:0004944) | 1.92986073 |
| 159 | Reticulocytopenia (HP:0001896) | 1.92965637 |
| 160 | Male pseudohermaphroditism (HP:0000037) | 1.92816731 |
| 161 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.92465380 |
| 162 | Retinitis pigmentosa (HP:0000510) | 1.91879962 |
| 163 | Lack of skin elasticity (HP:0100679) | 1.91786751 |
| 164 | Patellar aplasia (HP:0006443) | 1.91643166 |
| 165 | Decreased circulating renin level (HP:0003351) | 1.91365217 |
| 166 | Nonimmune hydrops fetalis (HP:0001790) | 1.91286788 |
| 167 | Methylmalonic aciduria (HP:0012120) | 1.91102434 |
| 168 | Ketoacidosis (HP:0001993) | 1.90570347 |
| 169 | Opisthotonus (HP:0002179) | 1.90456038 |
| 170 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.89983974 |
| 171 | Joint stiffness (HP:0001387) | 1.88917216 |
| 172 | Abnormality of alanine metabolism (HP:0010916) | 1.88235539 |
| 173 | Hyperalaninemia (HP:0003348) | 1.88235539 |
| 174 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.88235539 |
| 175 | Decreased subcutaneous fat (HP:0001002) | 1.88205138 |
| 176 | Patent foramen ovale (HP:0001655) | 1.87974388 |
| 177 | Premature ovarian failure (HP:0008209) | 1.87477653 |
| 178 | Broad face (HP:0000283) | 1.86967827 |
| 179 | Hyperventilation (HP:0002883) | 1.85206321 |
| 180 | Testicular atrophy (HP:0000029) | 1.85052652 |
| 181 | Muscle fiber splitting (HP:0003555) | 1.82901078 |
| 182 | Type I transferrin isoform profile (HP:0003642) | 1.82613405 |
| 183 | Neonatal short-limb short stature (HP:0008921) | 1.82496597 |
| 184 | Glycosuria (HP:0003076) | 1.82329402 |
| 185 | Progressive muscle weakness (HP:0003323) | 1.82105312 |
| 186 | Increased IgE level (HP:0003212) | 1.81834210 |
| 187 | Calcaneovalgus deformity (HP:0001848) | 1.81653192 |
| 188 | Fused cervical vertebrae (HP:0002949) | 1.78651045 |
| 189 | Gastrointestinal dysmotility (HP:0002579) | 1.78343345 |
| 190 | Stillbirth (HP:0003826) | 1.77267660 |
| 191 | Submucous cleft hard palate (HP:0000176) | 1.76754162 |
| 192 | Delayed cranial suture closure (HP:0000270) | 1.75857503 |
| 193 | Abnormal hemoglobin (HP:0011902) | 1.71272442 |
| 194 | Deformed tarsal bones (HP:0008119) | 1.68941137 |
| 195 | Concave nail (HP:0001598) | 1.68893679 |
| 196 | Alopecia of scalp (HP:0002293) | 1.68358959 |
| 197 | Pterygium (HP:0001059) | 1.67930413 |
| 198 | Single umbilical artery (HP:0001195) | 1.67791080 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 5.39698046 |
| 2 | FRK | 3.84324469 |
| 3 | PIM2 | 3.81386035 |
| 4 | BUB1 | 3.66777540 |
| 5 | ADRBK2 | 2.99734816 |
| 6 | WEE1 | 2.98904096 |
| 7 | MAP4K2 | 2.98426661 |
| 8 | PINK1 | 2.97436965 |
| 9 | WNK4 | 2.80961431 |
| 10 | TESK2 | 2.75941423 |
| 11 | EPHA2 | 2.75289942 |
| 12 | LATS2 | 2.72251284 |
| 13 | MAPK15 | 2.62085380 |
| 14 | EIF2AK1 | 2.59922181 |
| 15 | TESK1 | 2.55594024 |
| 16 | ARAF | 2.50350597 |
| 17 | NTRK2 | 2.50038425 |
| 18 | VRK2 | 2.41468540 |
| 19 | BCKDK | 2.27325112 |
| 20 | WNK3 | 2.11939018 |
| 21 | LIMK1 | 2.11262858 |
| 22 | MUSK | 2.06017562 |
| 23 | INSRR | 1.95730580 |
| 24 | RPS6KA4 | 1.88067321 |
| 25 | MAP2K7 | 1.79152212 |
| 26 | EIF2AK3 | 1.76186535 |
| 27 | MAPKAPK3 | 1.75330368 |
| 28 | TAOK3 | 1.74624638 |
| 29 | NEK2 | 1.72841445 |
| 30 | GRK1 | 1.69129816 |
| 31 | BRSK2 | 1.60493993 |
| 32 | DDR2 | 1.58339866 |
| 33 | IRAK3 | 1.54524022 |
| 34 | TRIB3 | 1.53903460 |
| 35 | ERN1 | 1.50443755 |
| 36 | MAPK13 | 1.49359624 |
| 37 | LRRK2 | 1.49276525 |
| 38 | STK39 | 1.46536100 |
| 39 | NUAK1 | 1.46075030 |
| 40 | TRIM28 | 1.45953132 |
| 41 | BMPR1B | 1.45302727 |
| 42 | ADRBK1 | 1.42801207 |
| 43 | MAP3K4 | 1.42735038 |
| 44 | PBK | 1.38439424 |
| 45 | TXK | 1.38030723 |
| 46 | DYRK3 | 1.35883956 |
| 47 | PAK4 | 1.34923226 |
| 48 | TTN | 1.31050038 |
| 49 | CASK | 1.30643244 |
| 50 | DYRK2 | 1.29197728 |
| 51 | MAP3K3 | 1.28081038 |
| 52 | BRAF | 1.23886540 |
| 53 | ACVR1B | 1.22582008 |
| 54 | SRPK1 | 1.21182375 |
| 55 | TSSK6 | 1.21060954 |
| 56 | RPS6KB2 | 1.18424506 |
| 57 | MAP3K11 | 1.18391580 |
| 58 | ABL2 | 1.17785748 |
| 59 | GRK5 | 1.15109799 |
| 60 | PLK4 | 1.14443044 |
| 61 | MAP3K8 | 1.14049998 |
| 62 | PAK1 | 1.12575483 |
| 63 | MOS | 1.12070416 |
| 64 | LATS1 | 1.10807271 |
| 65 | NEK1 | 1.10774503 |
| 66 | PAK2 | 1.09421011 |
| 67 | ILK | 1.07901810 |
| 68 | PLK1 | 1.06844974 |
| 69 | STK10 | 1.06573757 |
| 70 | SIK2 | 1.04976216 |
| 71 | TTK | 1.04005389 |
| 72 | CSNK1G3 | 1.02088405 |
| 73 | STK38L | 1.01186969 |
| 74 | NME1 | 1.00103481 |
| 75 | PLK2 | 0.99732182 |
| 76 | NEK9 | 0.98494095 |
| 77 | AURKB | 0.98159276 |
| 78 | PRKCG | 0.97886281 |
| 79 | PHKG1 | 0.95838804 |
| 80 | PHKG2 | 0.95838804 |
| 81 | AURKA | 0.95211856 |
| 82 | STK3 | 0.94897380 |
| 83 | ZAK | 0.93127004 |
| 84 | EEF2K | 0.91180260 |
| 85 | CSNK1A1L | 0.90052003 |
| 86 | SCYL2 | 0.89602027 |
| 87 | BCR | 0.88472244 |
| 88 | PAK3 | 0.87960432 |
| 89 | PLK3 | 0.85230876 |
| 90 | CSNK1G2 | 0.85081769 |
| 91 | CAMKK2 | 0.84796196 |
| 92 | MAP2K6 | 0.83809257 |
| 93 | MARK3 | 0.81846606 |
| 94 | PRKCE | 0.81778845 |
| 95 | RAF1 | 0.81001454 |
| 96 | MARK1 | 0.80726524 |
| 97 | GRK7 | 0.80026710 |
| 98 | MST4 | 0.78459690 |
| 99 | PRKCQ | 0.77863320 |
| 100 | OXSR1 | 0.77329822 |
| 101 | TAOK1 | 0.77288717 |
| 102 | BRSK1 | 0.74307863 |
| 103 | CDK7 | 0.71986912 |
| 104 | TRPM7 | 0.70666419 |
| 105 | DAPK2 | 0.70662417 |
| 106 | PRKCI | 0.70570846 |
| 107 | TIE1 | 0.70550209 |
| 108 | KDR | 0.69732146 |
| 109 | MAP3K10 | 0.69616600 |
| 110 | EPHB2 | 0.68798795 |
| 111 | EPHA3 | 0.66181071 |
| 112 | MAP2K3 | 0.66111528 |
| 113 | PDGFRA | 0.65585327 |
| 114 | PTK2B | 0.64823980 |
| 115 | MAP2K2 | 0.60937470 |
| 116 | PIM1 | 0.60895476 |
| 117 | CSNK1G1 | 0.60368456 |
| 118 | AKT3 | 0.60107320 |
| 119 | DAPK3 | 0.59808315 |
| 120 | CHEK2 | 0.57440290 |
| 121 | PTK2 | 0.57141642 |
| 122 | PKN1 | 0.57139779 |
| 123 | MAP2K1 | 0.56739311 |
| 124 | CDC7 | 0.55215861 |
| 125 | MAP4K1 | 0.54404517 |
| 126 | TNK2 | 0.54188006 |
| 127 | MAP3K2 | 0.54139133 |
| 128 | PKN2 | 0.54016135 |
| 129 | TNIK | 0.53157386 |
| 130 | PDK2 | 0.50833238 |
| 131 | KSR2 | 0.48468512 |
| 132 | IKBKB | 0.47357572 |
| 133 | MST1R | 0.45959477 |
| 134 | PRKACA | 0.45861456 |
| 135 | CSNK1A1 | 0.45418716 |
| 136 | CAMK2A | 0.42906576 |
| 137 | PRKCH | 0.42354814 |
| 138 | TAOK2 | 0.42123783 |
| 139 | MET | 0.41127863 |
| 140 | PRKCA | 0.40944413 |
| 141 | ZAP70 | 0.40312276 |
| 142 | RPS6KA5 | 0.40283256 |
| 143 | VRK1 | 0.39512232 |
| 144 | TLK1 | 0.39159842 |
| 145 | CDK8 | 0.38930346 |
| 146 | DAPK1 | 0.36261590 |
| 147 | CAMK2D | 0.35814221 |
| 148 | ERBB3 | 0.34680513 |
| 149 | PRKG2 | 0.33759635 |
| 150 | GRK6 | 0.32833021 |
| 151 | CSNK2A2 | 0.32243482 |
| 152 | MKNK1 | 0.32089452 |
| 153 | MTOR | 0.31980307 |
| 154 | CCNB1 | 0.31041905 |
| 155 | ALK | 0.29974600 |
| 156 | TBK1 | 0.29344801 |
| 157 | PRKCZ | 0.29321589 |
| 158 | MAPKAPK5 | 0.29061553 |
| 159 | MATK | 0.28939289 |
| 160 | PRKCD | 0.28559149 |
| 161 | MAPKAPK2 | 0.28295021 |
| 162 | CSNK2A1 | 0.28293987 |
| 163 | RPS6KA6 | 0.27723949 |
| 164 | BMX | 0.27600953 |
| 165 | STK16 | 0.27187019 |
| 166 | CAMK2G | 0.26011758 |
| 167 | MYLK | 0.25985935 |
| 168 | BLK | 0.25219406 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.46440826 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.14161589 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.94558149 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.70162934 |
| 5 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.52191918 |
| 6 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 3.04622751 |
| 7 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.85447995 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.65931593 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.45097805 |
| 10 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.39593903 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.35115680 |
| 12 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.32930327 |
| 13 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.23939546 |
| 14 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 2.15873238 |
| 15 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.12410159 |
| 16 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 2.08513056 |
| 17 | Phototransduction_Homo sapiens_hsa04744 | 2.06452990 |
| 18 | Spliceosome_Homo sapiens_hsa03040 | 1.98940263 |
| 19 | Cell cycle_Homo sapiens_hsa04110 | 1.91728485 |
| 20 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.82765786 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.80056498 |
| 22 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.68093254 |
| 23 | Alzheimers disease_Homo sapiens_hsa05010 | 1.67876044 |
| 24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.66889171 |
| 25 | Base excision repair_Homo sapiens_hsa03410 | 1.61744184 |
| 26 | Olfactory transduction_Homo sapiens_hsa04740 | 1.61619951 |
| 27 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.58426973 |
| 28 | Mismatch repair_Homo sapiens_hsa03430 | 1.57866681 |
| 29 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.55336292 |
| 30 | Nicotine addiction_Homo sapiens_hsa05033 | 1.48635855 |
| 31 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.48411472 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.44857239 |
| 33 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.43534470 |
| 34 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.43217185 |
| 35 | Homologous recombination_Homo sapiens_hsa03440 | 1.42470581 |
| 36 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.40796806 |
| 37 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.39833001 |
| 38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.39807308 |
| 39 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.36919376 |
| 40 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.36359391 |
| 41 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.36091846 |
| 42 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.34230915 |
| 43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.29911244 |
| 44 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.29190485 |
| 45 | Bladder cancer_Homo sapiens_hsa05219 | 1.27569253 |
| 46 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.26741857 |
| 47 | Basal transcription factors_Homo sapiens_hsa03022 | 1.25942953 |
| 48 | Sulfur relay system_Homo sapiens_hsa04122 | 1.23386855 |
| 49 | Shigellosis_Homo sapiens_hsa05131 | 1.22486760 |
| 50 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.21862485 |
| 51 | Taste transduction_Homo sapiens_hsa04742 | 1.21576778 |
| 52 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.21455079 |
| 53 | Peroxisome_Homo sapiens_hsa04146 | 1.21384035 |
| 54 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.21165097 |
| 55 | Purine metabolism_Homo sapiens_hsa00230 | 1.20700941 |
| 56 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.16617420 |
| 57 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.14965101 |
| 58 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.13717283 |
| 59 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.13077226 |
| 60 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.09436439 |
| 61 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.06500750 |
| 62 | Apoptosis_Homo sapiens_hsa04210 | 1.05593290 |
| 63 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.03142727 |
| 64 | Thyroid cancer_Homo sapiens_hsa05216 | 1.02931343 |
| 65 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.02922904 |
| 66 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.96416942 |
| 67 | Protein export_Homo sapiens_hsa03060 | 0.94930141 |
| 68 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.92489474 |
| 69 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.90860524 |
| 70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.89881543 |
| 71 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.89625318 |
| 72 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.89466294 |
| 73 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.89127570 |
| 74 | Morphine addiction_Homo sapiens_hsa05032 | 0.88068279 |
| 75 | Lysosome_Homo sapiens_hsa04142 | 0.85834689 |
| 76 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.85799679 |
| 77 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.85430505 |
| 78 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.85118538 |
| 79 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.84658296 |
| 80 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.83574176 |
| 81 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.80658516 |
| 82 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.80152832 |
| 83 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.80128164 |
| 84 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.78896402 |
| 85 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.76585780 |
| 86 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.76215825 |
| 87 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.75601637 |
| 88 | Phagosome_Homo sapiens_hsa04145 | 0.74549248 |
| 89 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.74129923 |
| 90 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.73255812 |
| 91 | Legionellosis_Homo sapiens_hsa05134 | 0.72913968 |
| 92 | Huntingtons disease_Homo sapiens_hsa05016 | 0.72685569 |
| 93 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.70736421 |
| 94 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.70626034 |
| 95 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.69897678 |
| 96 | RNA degradation_Homo sapiens_hsa03018 | 0.69358999 |
| 97 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.68791736 |
| 98 | GABAergic synapse_Homo sapiens_hsa04727 | 0.68133534 |
| 99 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.68045957 |
| 100 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.65986095 |
| 101 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65811419 |
| 102 | Retinol metabolism_Homo sapiens_hsa00830 | 0.64279777 |
| 103 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.64111484 |
| 104 | ABC transporters_Homo sapiens_hsa02010 | 0.63765127 |
| 105 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.63534809 |
| 106 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.63405521 |
| 107 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.62156886 |
| 108 | Focal adhesion_Homo sapiens_hsa04510 | 0.61774551 |
| 109 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.60406932 |
| 110 | Salivary secretion_Homo sapiens_hsa04970 | 0.60038158 |
| 111 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.59819939 |
| 112 | Malaria_Homo sapiens_hsa05144 | 0.59783819 |
| 113 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58753582 |
| 114 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.58115566 |
| 115 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.56021812 |
| 116 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.55162463 |
| 117 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.54680284 |
| 118 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.54647832 |
| 119 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.54491907 |
| 120 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.53907761 |
| 121 | Adherens junction_Homo sapiens_hsa04520 | 0.52696489 |
| 122 | Parkinsons disease_Homo sapiens_hsa05012 | 0.51661847 |
| 123 | Insulin secretion_Homo sapiens_hsa04911 | 0.51061257 |
| 124 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.50125250 |
| 125 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.49669051 |
| 126 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.49591352 |
| 127 | Melanoma_Homo sapiens_hsa05218 | 0.49084831 |
| 128 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.47947460 |
| 129 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.47906577 |
| 130 | Hepatitis B_Homo sapiens_hsa05161 | 0.47549377 |
| 131 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.47462869 |
| 132 | Salmonella infection_Homo sapiens_hsa05132 | 0.47339939 |
| 133 | Asthma_Homo sapiens_hsa05310 | 0.47242252 |
| 134 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.47126911 |
| 135 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.47109223 |
| 136 | Tight junction_Homo sapiens_hsa04530 | 0.47096638 |
| 137 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.46882194 |
| 138 | Tuberculosis_Homo sapiens_hsa05152 | 0.46750489 |
| 139 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.46536269 |
| 140 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.46398244 |
| 141 | Circadian entrainment_Homo sapiens_hsa04713 | 0.45654951 |
| 142 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.45244839 |
| 143 | Cocaine addiction_Homo sapiens_hsa05030 | 0.44837407 |
| 144 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.44587465 |
| 145 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.44015259 |
| 146 | Mineral absorption_Homo sapiens_hsa04978 | 0.43864967 |
| 147 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.43678749 |
| 148 | Galactose metabolism_Homo sapiens_hsa00052 | 0.42790463 |
| 149 | Other glycan degradation_Homo sapiens_hsa00511 | 0.42516419 |
| 150 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.42200493 |
| 151 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.42008297 |
| 152 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.41198797 |
| 153 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.40796872 |
| 154 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.40235858 |
| 155 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.40176350 |
| 156 | Prostate cancer_Homo sapiens_hsa05215 | 0.39027968 |
| 157 | Amoebiasis_Homo sapiens_hsa05146 | 0.38494669 |
| 158 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.38321594 |
| 159 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.38315500 |
| 160 | Leishmaniasis_Homo sapiens_hsa05140 | 0.38282142 |
| 161 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.38275223 |
| 162 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.37887774 |
| 163 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.37140441 |
| 164 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.36913095 |
| 165 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.36724882 |
| 166 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.35825139 |
| 167 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.35514256 |
| 168 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.35402555 |
| 169 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.34593117 |
| 170 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.33288655 |
| 171 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.32572993 |
| 172 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.31237579 |
| 173 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.30449733 |

