PTRH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.69926619
2DNA deamination (GO:0045006)5.29674129
3viral transcription (GO:0019083)5.28540602
4maturation of SSU-rRNA (GO:0030490)5.21796713
5ribosomal small subunit biogenesis (GO:0042274)5.21094357
6translational termination (GO:0006415)5.17297133
7ribosomal large subunit biogenesis (GO:0042273)4.80282437
8telomere maintenance via semi-conservative replication (GO:0032201)4.64724588
9proteasome assembly (GO:0043248)4.62608436
10DNA strand elongation involved in DNA replication (GO:0006271)4.60139206
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.59381957
12translational elongation (GO:0006414)4.56214719
13cotranslational protein targeting to membrane (GO:0006613)4.53338788
14protein targeting to ER (GO:0045047)4.47969759
15DNA strand elongation (GO:0022616)4.42345526
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.34266145
17termination of RNA polymerase III transcription (GO:0006386)4.34266145
18translational initiation (GO:0006413)4.32910483
19DNA replication initiation (GO:0006270)4.27303196
20CENP-A containing nucleosome assembly (GO:0034080)4.27238570
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.24974090
22protein localization to endoplasmic reticulum (GO:0070972)4.23767552
23telomere maintenance via recombination (GO:0000722)4.22251306
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.20822510
25chromatin remodeling at centromere (GO:0031055)4.12150584
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10811410
27cellular protein complex disassembly (GO:0043624)4.09854169
28respiratory chain complex IV assembly (GO:0008535)4.08785154
29rRNA methylation (GO:0031167)4.06415329
30ribonucleoprotein complex biogenesis (GO:0022613)4.04975844
31formation of translation preinitiation complex (GO:0001731)4.03227017
32DNA replication checkpoint (GO:0000076)4.02303105
33viral life cycle (GO:0019058)3.99985624
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93720510
35translation (GO:0006412)3.92804853
36establishment of integrated proviral latency (GO:0075713)3.92331195
37pseudouridine synthesis (GO:0001522)3.91442190
38spliceosomal snRNP assembly (GO:0000387)3.90758936
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88716011
40regulation of mitochondrial translation (GO:0070129)3.88477367
41rRNA processing (GO:0006364)3.87983258
42mitotic recombination (GO:0006312)3.86626694
43cytochrome complex assembly (GO:0017004)3.79608768
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.75853477
457-methylguanosine mRNA capping (GO:0006370)3.75183082
46rRNA metabolic process (GO:0016072)3.74266105
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74265484
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72124171
497-methylguanosine RNA capping (GO:0009452)3.71225311
50RNA capping (GO:0036260)3.71225311
51rRNA modification (GO:0000154)3.71026278
52kinetochore assembly (GO:0051382)3.68296592
53respiratory electron transport chain (GO:0022904)3.68105621
54kinetochore organization (GO:0051383)3.66622401
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65869389
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64587687
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64490637
58telomere maintenance via telomere lengthening (GO:0010833)3.64267832
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.61595863
60electron transport chain (GO:0022900)3.61199252
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60684533
62cellular component biogenesis (GO:0044085)3.60526466
63transcription-coupled nucleotide-excision repair (GO:0006283)3.60136095
64protein complex disassembly (GO:0043241)3.59493912
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.58026687
66cullin deneddylation (GO:0010388)3.57755020
67purine nucleobase biosynthetic process (GO:0009113)3.57209264
68nucleobase biosynthetic process (GO:0046112)3.54832338
69energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54464560
70ATP synthesis coupled proton transport (GO:0015986)3.54464560
71protein deneddylation (GO:0000338)3.53415863
72DNA replication-independent nucleosome organization (GO:0034724)3.53304753
73DNA replication-independent nucleosome assembly (GO:0006336)3.53304753
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52902697
75negative regulation of ligase activity (GO:0051352)3.52902697
76ribosome assembly (GO:0042255)3.49954467
77spliceosomal complex assembly (GO:0000245)3.45821044
78macromolecular complex disassembly (GO:0032984)3.45076018
79DNA unwinding involved in DNA replication (GO:0006268)3.41294489
80maturation of 5.8S rRNA (GO:0000460)3.39359970
81transcription from mitochondrial promoter (GO:0006390)3.38028850
82mitochondrial respiratory chain complex I assembly (GO:0032981)3.37978423
83NADH dehydrogenase complex assembly (GO:0010257)3.37978423
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37978423
85nuclear-transcribed mRNA catabolic process (GO:0000956)3.36445032
86mitochondrial RNA metabolic process (GO:0000959)3.36275365
87replication fork processing (GO:0031297)3.35474925
88histone exchange (GO:0043486)3.35072780
89ribosome biogenesis (GO:0042254)3.34186671
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33126148
91protein complex biogenesis (GO:0070271)3.32974089
92metaphase plate congression (GO:0051310)3.32848634
93protein targeting to mitochondrion (GO:0006626)3.32322751
94transcription elongation from RNA polymerase I promoter (GO:0006362)3.29855177
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28560267
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28560267
97regulation of cellular amino acid metabolic process (GO:0006521)3.27868621
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27375919
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27375919
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27375919
101positive regulation of ligase activity (GO:0051351)3.23878727
102deoxyribonucleotide biosynthetic process (GO:0009263)3.22219726
103chaperone-mediated protein transport (GO:0072321)3.21835046
104viral mRNA export from host cell nucleus (GO:0046784)3.21305828
105histone mRNA metabolic process (GO:0008334)3.21229180
106termination of RNA polymerase I transcription (GO:0006363)3.21149320
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21096475
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21096475
109mRNA catabolic process (GO:0006402)3.19902009
110transcription from RNA polymerase I promoter (GO:0006360)3.19772147
111oxidative phosphorylation (GO:0006119)3.19742487
112establishment of viral latency (GO:0019043)3.18550074
113signal transduction involved in DNA damage checkpoint (GO:0072422)3.18480767
114signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18480767
115mitotic metaphase plate congression (GO:0007080)3.18325495
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18015365
117GTP biosynthetic process (GO:0006183)3.17148193
118signal transduction involved in cell cycle checkpoint (GO:0072395)3.16559400
119mitochondrial respiratory chain complex assembly (GO:0033108)3.15732692
120peptidyl-histidine modification (GO:0018202)3.13095711
121protein localization to kinetochore (GO:0034501)3.07702521
122regulation of mitotic spindle checkpoint (GO:1903504)3.07617889
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07617889
124establishment of protein localization to mitochondrion (GO:0072655)3.06985436
125protein localization to mitochondrion (GO:0070585)3.06912000
126regulation of ubiquitin-protein transferase activity (GO:0051438)3.06175567
127DNA ligation (GO:0006266)3.00596658
128DNA double-strand break processing (GO:0000729)2.98426650
129regulation of ligase activity (GO:0051340)2.95951252
130tRNA processing (GO:0008033)2.94395803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.15065977
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.72211426
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55935181
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.87333237
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.78949936
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72732679
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68881773
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.47245457
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44905032
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23778073
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21886216
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20127496
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18924648
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08380301
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.06294638
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97010240
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.86854967
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82621167
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79168487
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78550059
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73381088
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72756135
23VDR_23849224_ChIP-Seq_CD4+_Human2.62230277
24XRN2_22483619_ChIP-Seq_HELA_Human2.57879674
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39233210
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.36374493
27DCP1A_22483619_ChIP-Seq_HELA_Human2.32540419
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31448891
29FOXP3_21729870_ChIP-Seq_TREG_Human2.22573956
30TTF2_22483619_ChIP-Seq_HELA_Human2.21174969
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16568437
32* GABP_19822575_ChIP-Seq_HepG2_Human2.10134527
33* SRF_21415370_ChIP-Seq_HL-1_Mouse2.07603311
34ELK1_19687146_ChIP-ChIP_HELA_Human2.06877832
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96401210
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95441102
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94997302
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.91258746
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89647850
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87990240
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81008779
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79356044
43AR_21909140_ChIP-Seq_LNCAP_Human1.79277732
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78344456
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75605770
46* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73450254
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73175215
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71726725
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68132614
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.66615379
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65443378
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57349465
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53638147
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48549731
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46472062
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.44842835
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43480688
58MYC_18940864_ChIP-ChIP_HL60_Human1.38351041
59EWS_26573619_Chip-Seq_HEK293_Human1.38016092
60CIITA_25753668_ChIP-Seq_RAJI_Human1.36886506
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33735326
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.31276320
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30937737
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30265550
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26967408
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25547177
67KDM5A_27292631_Chip-Seq_BREAST_Human1.23248039
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20600488
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19194684
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18608840
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.18405616
72* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16211293
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10690428
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09058575
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08951400
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07774834
77ELF5_23300383_ChIP-Seq_T47D_Human1.05299496
78ZNF274_21170338_ChIP-Seq_K562_Hela1.05151607
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03777051
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.01551122
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00474739
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99337899
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98718334
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96614011
85* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93454694
86IRF1_19129219_ChIP-ChIP_H3396_Human0.92944402
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89706867
88FUS_26573619_Chip-Seq_HEK293_Human0.88639578
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87708317
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80565937
91TFEB_21752829_ChIP-Seq_HELA_Human0.79226217
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77761426
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77568196
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.77256267
95* SPI1_23547873_ChIP-Seq_NB4_Human0.77101739
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76637825
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75757198
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75151410
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74492882
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73703244
101CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73437900
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71304365
103VDR_22108803_ChIP-Seq_LS180_Human0.70156912
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.66382237
105* TP53_22573176_ChIP-Seq_HFKS_Human0.66214926
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65219049
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.65031549
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.64702634
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64514231
110ZNF263_19887448_ChIP-Seq_K562_Human0.62068815
111* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.61999515
112* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.61463260
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.61398521
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.60722172
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59903956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12996969
2MP0010094_abnormal_chromosome_stability4.45363419
3MP0008057_abnormal_DNA_replication4.22182964
4MP0004957_abnormal_blastocyst_morpholog4.07534645
5MP0003111_abnormal_nucleus_morphology3.82522412
6MP0008058_abnormal_DNA_repair3.81959785
7MP0003077_abnormal_cell_cycle3.68458642
8MP0009379_abnormal_foot_pigmentation3.28590270
9MP0008932_abnormal_embryonic_tissue2.99001980
10MP0008007_abnormal_cellular_replicative2.97000652
11MP0006292_abnormal_olfactory_placode2.87767924
12MP0003786_premature_aging2.20320891
13MP0003123_paternal_imprinting2.12085169
14MP0001529_abnormal_vocalization2.09948256
15MP0008877_abnormal_DNA_methylation2.06360731
16MP0003315_abnormal_perineum_morphology2.06156099
17MP0002396_abnormal_hematopoietic_system1.93267846
18MP0010030_abnormal_orbit_morphology1.92993734
19MP0002102_abnormal_ear_morphology1.91311496
20MP0003806_abnormal_nucleotide_metabolis1.90410963
21MP0003718_maternal_effect1.88573544
22MP0009697_abnormal_copulation1.72214512
23MP0001730_embryonic_growth_arrest1.71563147
24MP0002938_white_spotting1.71425463
25MP0003941_abnormal_skin_development1.67848483
26MP0003950_abnormal_plasma_membrane1.66229182
27MP0002132_abnormal_respiratory_system1.62629787
28MP0000350_abnormal_cell_proliferation1.59335977
29MP0003186_abnormal_redox_activity1.47727021
30MP0000490_abnormal_crypts_of1.46932682
31MP0006036_abnormal_mitochondrial_physio1.46419609
32MP0008789_abnormal_olfactory_epithelium1.46115725
33MP0003890_abnormal_embryonic-extraembry1.36321458
34MP0000566_synostosis1.28759308
35MP0000372_irregular_coat_pigmentation1.27578591
36MP0004147_increased_porphyrin_level1.27171024
37MP0001697_abnormal_embryo_size1.25159360
38MP0008995_early_reproductive_senescence1.23452180
39MP0002210_abnormal_sex_determination1.22565277
40MP0002163_abnormal_gland_morphology1.21985977
41MP0003121_genomic_imprinting1.21395970
42MP0002638_abnormal_pupillary_reflex1.21043581
43* MP0000313_abnormal_cell_death1.20229364
44MP0003195_calcinosis1.17717126
45MP0008872_abnormal_physiological_respon1.17654273
46MP0001293_anophthalmia1.17504966
47MP0002160_abnormal_reproductive_system1.16916744
48MP0004133_heterotaxia1.16786968
49MP0001905_abnormal_dopamine_level1.15324534
50MP0000049_abnormal_middle_ear1.12845590
51MP0002080_prenatal_lethality1.11395096
52MP0002095_abnormal_skin_pigmentation1.10729109
53MP0005395_other_phenotype1.10004029
54MP0001661_extended_life_span1.08948605
55MP0005408_hypopigmentation1.07964654
56MP0008875_abnormal_xenobiotic_pharmacok1.06658861
57MP0003763_abnormal_thymus_physiology1.05677996
58MP0001672_abnormal_embryogenesis/_devel1.04510679
59MP0005380_embryogenesis_phenotype1.04510679
60MP0003567_abnormal_fetal_cardiomyocyte1.04072482
61MP0002019_abnormal_tumor_incidence1.03992176
62MP0009333_abnormal_splenocyte_physiolog1.03636467
63MP0001145_abnormal_male_reproductive1.01817297
64MP0002085_abnormal_embryonic_tissue1.01431637
65MP0001188_hyperpigmentation1.00980886
66MP0005084_abnormal_gallbladder_morpholo1.00242853
67MP0000015_abnormal_ear_pigmentation0.99553307
68MP0003656_abnormal_erythrocyte_physiolo0.99416743
69MP0006035_abnormal_mitochondrial_morpho0.96962409
70MP0003011_delayed_dark_adaptation0.96227165
71MP0004808_abnormal_hematopoietic_stem0.96123493
72MP0002736_abnormal_nociception_after0.95944086
73MP0003136_yellow_coat_color0.95836455
74MP0005075_abnormal_melanosome_morpholog0.95299678
75MP0001119_abnormal_female_reproductive0.93352571
76MP0005174_abnormal_tail_pigmentation0.92947269
77MP0000653_abnormal_sex_gland0.92661731
78MP0002111_abnormal_tail_morphology0.91840834
79MP0000537_abnormal_urethra_morphology0.91446263
80MP0005389_reproductive_system_phenotype0.90418950
81MP0001929_abnormal_gametogenesis0.90416721
82MP0003938_abnormal_ear_development0.88562806
83MP0002277_abnormal_respiratory_mucosa0.88116299
84MP0003937_abnormal_limbs/digits/tail_de0.88087442
85MP0000427_abnormal_hair_cycle0.87953105
86MP0002751_abnormal_autonomic_nervous0.87310486
87MP0009672_abnormal_birth_weight0.87011152
88MP0002234_abnormal_pharynx_morphology0.86851773
89MP0000647_abnormal_sebaceous_gland0.86589679
90MP0005394_taste/olfaction_phenotype0.85718424
91MP0005499_abnormal_olfactory_system0.85718424
92MP0003984_embryonic_growth_retardation0.84987524
93MP0000703_abnormal_thymus_morphology0.84874783
94MP0002088_abnormal_embryonic_growth/wei0.83551166
95MP0006276_abnormal_autonomic_nervous0.82629190
96MP0005409_darkened_coat_color0.81255871
97MP0001853_heart_inflammation0.80274475
98MP0001286_abnormal_eye_development0.79961246
99MP0001764_abnormal_homeostasis0.79146726
100MP0005253_abnormal_eye_physiology0.78884728
101MP0000371_diluted_coat_color0.77804002
102MP0001186_pigmentation_phenotype0.77107775
103MP0002084_abnormal_developmental_patter0.73807445
104MP0000358_abnormal_cell_content/0.72659883
105MP0006054_spinal_hemorrhage0.72232115
106MP0001881_abnormal_mammary_gland0.71694949
107MP0002398_abnormal_bone_marrow0.71527823
108MP0005671_abnormal_response_to0.71483020
109MP0003698_abnormal_male_reproductive0.70398395
110MP0002722_abnormal_immune_system0.69810800
111MP0002233_abnormal_nose_morphology0.69610127
112MP0005646_abnormal_pituitary_gland0.69478429
113MP0004381_abnormal_hair_follicle0.67914756
114MP0005551_abnormal_eye_electrophysiolog0.67773388
115MP0004142_abnormal_muscle_tone0.67480143
116MP0001919_abnormal_reproductive_system0.64980765
117MP0000689_abnormal_spleen_morphology0.64930571
118MP0003699_abnormal_female_reproductive0.64251858
119MP0000631_abnormal_neuroendocrine_gland0.63697193
120MP0009703_decreased_birth_body0.63605910
121MP0001727_abnormal_embryo_implantation0.63205026
122MP0005332_abnormal_amino_acid0.63091394
123MP0003755_abnormal_palate_morphology0.62634336
124MP0001324_abnormal_eye_pigmentation0.61983990
125MP0006072_abnormal_retinal_apoptosis0.61664222
126MP0005410_abnormal_fertilization0.61379117
127* MP0002429_abnormal_blood_cell0.59398102
128MP0002282_abnormal_trachea_morphology0.58241291
129MP0005171_absent_coat_pigmentation0.57628714
130MP0010307_abnormal_tumor_latency0.57315222
131MP0002075_abnormal_coat/hair_pigmentati0.56127961
132MP0002086_abnormal_extraembryonic_tissu0.55937578
133MP0004197_abnormal_fetal_growth/weight/0.55224953

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.02108726
2Abnormal number of erythroid precursors (HP:0012131)5.60267300
3Birth length less than 3rd percentile (HP:0003561)5.36197457
4Reticulocytopenia (HP:0001896)4.74214584
5Acute necrotizing encephalopathy (HP:0006965)4.63265498
6Abnormal mitochondria in muscle tissue (HP:0008316)4.13618214
7Mitochondrial inheritance (HP:0001427)4.06522116
8Macrocytic anemia (HP:0001972)3.79332897
9Progressive macrocephaly (HP:0004481)3.75819855
10Breast hypoplasia (HP:0003187)3.73123765
11Increased CSF lactate (HP:0002490)3.62784180
12Acute encephalopathy (HP:0006846)3.62277332
13Pallor (HP:0000980)3.48059971
14Hepatocellular necrosis (HP:0001404)3.45128438
15Microvesicular hepatic steatosis (HP:0001414)3.42832768
16Abnormality of glycolysis (HP:0004366)3.39136781
17Increased serum pyruvate (HP:0003542)3.39136781
18Increased hepatocellular lipid droplets (HP:0006565)3.36045578
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35269870
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35269870
21Colon cancer (HP:0003003)3.27000228
22Aplastic anemia (HP:0001915)3.22731696
23Oral leukoplakia (HP:0002745)3.21071942
243-Methylglutaconic aciduria (HP:0003535)3.04085526
25Cerebral hypomyelination (HP:0006808)2.98779010
26Short middle phalanx of the 5th finger (HP:0004220)2.95451361
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94913333
28Increased serum lactate (HP:0002151)2.94802522
29Lipid accumulation in hepatocytes (HP:0006561)2.92945031
30Hepatic necrosis (HP:0002605)2.87291303
31Patellar aplasia (HP:0006443)2.86591884
32Abnormality of alanine metabolism (HP:0010916)2.86558048
33Hyperalaninemia (HP:0003348)2.86558048
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86558048
35Exercise intolerance (HP:0003546)2.79219262
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74646663
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74632056
38Aplasia/Hypoplasia of the patella (HP:0006498)2.66705864
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.66402454
40Rough bone trabeculation (HP:0100670)2.64529322
4111 pairs of ribs (HP:0000878)2.60675493
42Abnormality of the preputium (HP:0100587)2.56687759
43Renal Fanconi syndrome (HP:0001994)2.53916996
44Type I transferrin isoform profile (HP:0003642)2.53194652
45Cerebral edema (HP:0002181)2.48168196
46Horseshoe kidney (HP:0000085)2.46586617
47Supernumerary spleens (HP:0009799)2.45201379
48Chromsome breakage (HP:0040012)2.43864439
49Meckel diverticulum (HP:0002245)2.43708147
50Agnosia (HP:0010524)2.42008061
51Lactic acidosis (HP:0003128)2.41865708
52Exertional dyspnea (HP:0002875)2.39742206
53Respiratory failure (HP:0002878)2.39513025
54Amniotic constriction ring (HP:0009775)2.36693209
55Abnormality of placental membranes (HP:0011409)2.36693209
56Absent thumb (HP:0009777)2.34495353
57Respiratory difficulties (HP:0002880)2.34051878
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33913818
59Abnormality of the ileum (HP:0001549)2.31997808
60Abnormality of methionine metabolism (HP:0010901)2.30006075
61Abnormal lung lobation (HP:0002101)2.29770921
62CNS demyelination (HP:0007305)2.27978389
63Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.24393032
64Premature graying of hair (HP:0002216)2.23143111
65Abnormality of chromosome stability (HP:0003220)2.22801552
66Triphalangeal thumb (HP:0001199)2.21744366
67Trismus (HP:0000211)2.19751893
68Abnormality of the anterior horn cell (HP:0006802)2.18456306
69Degeneration of anterior horn cells (HP:0002398)2.18456306
70Abnormality of the duodenum (HP:0002246)2.17464215
71Selective tooth agenesis (HP:0001592)2.17208534
72Microretrognathia (HP:0000308)2.16956947
73Hyperinsulinemic hypoglycemia (HP:0000825)2.13512086
74Glossoptosis (HP:0000162)2.12467069
75Abnormality of the pons (HP:0007361)2.10805974
76Lethargy (HP:0001254)2.10726330
77Leukodystrophy (HP:0002415)2.10468159
78Medulloblastoma (HP:0002885)2.08772393
79Testicular atrophy (HP:0000029)2.08145875
80Carpal bone hypoplasia (HP:0001498)2.07170217
81Increased intramyocellular lipid droplets (HP:0012240)2.07149068
82Hypoplasia of the radius (HP:0002984)2.06519107
83Optic disc pallor (HP:0000543)2.05922873
84Hypoplasia of the pons (HP:0012110)2.03775279
85Secondary amenorrhea (HP:0000869)2.03077128
86Abnormal trabecular bone morphology (HP:0100671)2.02692044
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.02389941
88Type 2 muscle fiber atrophy (HP:0003554)2.01668446
89Methylmalonic acidemia (HP:0002912)2.01469156
90Abnormal number of incisors (HP:0011064)1.99597480
91Stenosis of the external auditory canal (HP:0000402)1.99282036
92Abnormality of serum amino acid levels (HP:0003112)1.98338881
93Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.98250718
94Sparse eyelashes (HP:0000653)1.96488109
95Reduced antithrombin III activity (HP:0001976)1.96337117
96Progressive muscle weakness (HP:0003323)1.96174140
97Sloping forehead (HP:0000340)1.95871643
98Aplasia/Hypoplasia of the sternum (HP:0006714)1.94432597
99Duplicated collecting system (HP:0000081)1.94407187
100Small intestinal stenosis (HP:0012848)1.93634057
101Duodenal stenosis (HP:0100867)1.93634057
102Bone marrow hypocellularity (HP:0005528)1.91666011
103Abnormality of the labia minora (HP:0012880)1.90925116
104Pancytopenia (HP:0001876)1.90753983
105Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90552775
106Acanthocytosis (HP:0001927)1.89051598
107Muscle fiber atrophy (HP:0100295)1.88283862
108Poor head control (HP:0002421)1.87285885
109Atresia of the external auditory canal (HP:0000413)1.86458672
110Slender long bone (HP:0003100)1.86383983
111Increased muscle lipid content (HP:0009058)1.85908381
112Cellular immunodeficiency (HP:0005374)1.85160885
113Aplasia/hypoplasia of the uterus (HP:0008684)1.84663889
114Cleft eyelid (HP:0000625)1.83435094
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83419985
116Abnormality of the renal collecting system (HP:0004742)1.82619519
117Methylmalonic aciduria (HP:0012120)1.82551756
118Abnormality of renal resorption (HP:0011038)1.82245453
119Rhabdomyosarcoma (HP:0002859)1.80457953
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79735387
121Abnormal protein N-linked glycosylation (HP:0012347)1.79735387
122Abnormal protein glycosylation (HP:0012346)1.79735387
123Abnormal glycosylation (HP:0012345)1.79735387
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79069118
125Pancreatic cysts (HP:0001737)1.78559947
126Myelodysplasia (HP:0002863)1.78489104
127Homocystinuria (HP:0002156)1.78273567
128Abnormality of homocysteine metabolism (HP:0010919)1.78273567
129Hypoglycemic coma (HP:0001325)1.78224575
130Abnormality of the carotid arteries (HP:0005344)1.77153986
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.75011466
132Absent radius (HP:0003974)1.73518340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.38482895
2VRK24.18127001
3EIF2AK14.14871508
4NME23.61535449
5STK163.60285682
6WEE13.39034278
7PDK23.27135653
8VRK12.97091595
9SRPK12.82877781
10TLK12.82191853
11CDC72.64113537
12CDK192.54481110
13MKNK12.29920400
14EIF2AK32.28102860
15ACVR1B2.17628785
16PLK42.15622939
17NUAK12.05352386
18DYRK31.90062722
19CDK81.87040027
20MKNK21.82071495
21BRSK21.68580682
22CCNB11.64000178
23PLK31.63834311
24PLK11.58232195
25TSSK61.58141411
26RPS6KB21.44719127
27AURKB1.44346203
28TRIM281.42132250
29NME11.41497515
30PBK1.40654643
31CDK71.39485648
32ZAK1.38252056
33ATR1.32374347
34MAPKAPK31.27238504
35AURKA1.26132107
36BRSK11.23738080
37PIM21.22636927
38EIF2AK21.18864639
39PASK1.17841012
40KDR1.14673382
41TESK21.11414207
42CHEK21.09790158
43DYRK21.09278953
44TTK1.07320313
45TAF11.05579675
46NEK21.05061982
47MAPKAPK51.01893330
48TGFBR10.99341189
49BMPR1B0.97871770
50SCYL20.97287160
51MAP4K20.90493078
52EEF2K0.86945305
53BRD40.81811881
54MST40.81577815
55RPS6KA40.79271500
56CSNK2A20.79099612
57IRAK40.77600000
58CHEK10.76487272
59YES10.76402707
60BRAF0.76173296
61MAPK130.75410118
62CSNK2A10.75151479
63MAP3K120.71864242
64CSNK1G30.70899140
65NEK10.70711483
66MAP3K100.68833503
67WNK30.66574766
68TNIK0.65794514
69CDK40.65000017
70STK40.64775771
71CDK120.64026985
72ILK0.62799957
73ERBB40.59831087
74RPS6KA50.59744176
75OXSR10.58980154
76ATM0.55758696
77TEC0.54696153
78MAP3K80.53968711
79MST1R0.52788224
80STK390.52143697
81LIMK10.52048886
82DAPK10.51953594
83ABL20.51298629
84CSNK1G10.50425659
85AKT30.50271881
86BCKDK0.50043376
87MAP2K70.50040757
88CSNK1A1L0.48130719
89CDK20.47801232
90PAK40.47183687
91GRK10.47129550
92STK240.45375028
93EPHA20.44520140
94STK38L0.44401543
95MET0.42597225
96INSRR0.42270410
97CSNK1E0.41890016
98PAK10.41804011
99ALK0.41651426
100PIM10.41542909
101ARAF0.41020646
102CDK30.40293561
103CDK10.39872741
104ADRBK20.39850287
105BCR0.38221258
106MELK0.37738928
107STK100.37722810
108NLK0.34640623
109PNCK0.34290446
110STK30.33466933
111NEK60.32991907
112FGFR10.32932503
113CDK90.32417253
114FLT30.31355759
115DAPK30.29642636
116CDK11A0.29509178
117CSNK1G20.29050086
118PLK20.28365536
119FRK0.28158357
120CSNK1A10.25746528
121CLK10.25173199
122PRKCI0.25137264
123NEK90.24258185
124IRAK10.24158627
125SIK30.23813609
126MAP3K110.23437945
127ERBB30.22933686
128LYN0.22499891
129OBSCN0.22468648

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.05783540
2DNA replication_Homo sapiens_hsa030304.53076097
3Mismatch repair_Homo sapiens_hsa034304.22668628
4Proteasome_Homo sapiens_hsa030504.18032865
5RNA polymerase_Homo sapiens_hsa030204.06606397
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16352344
7Spliceosome_Homo sapiens_hsa030403.11437923
8Homologous recombination_Homo sapiens_hsa034402.95076960
9Pyrimidine metabolism_Homo sapiens_hsa002402.79743438
10Nucleotide excision repair_Homo sapiens_hsa034202.76244991
11RNA transport_Homo sapiens_hsa030132.46011634
12Oxidative phosphorylation_Homo sapiens_hsa001902.44533658
13Parkinsons disease_Homo sapiens_hsa050122.38384465
14Base excision repair_Homo sapiens_hsa034102.37840898
15Protein export_Homo sapiens_hsa030602.20062984
16Cell cycle_Homo sapiens_hsa041102.11788634
17Non-homologous end-joining_Homo sapiens_hsa034502.09528301
18Fanconi anemia pathway_Homo sapiens_hsa034602.07478516
19Basal transcription factors_Homo sapiens_hsa030221.98213272
20One carbon pool by folate_Homo sapiens_hsa006701.91445678
21Huntingtons disease_Homo sapiens_hsa050161.89102646
22RNA degradation_Homo sapiens_hsa030181.87603543
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86378647
24Purine metabolism_Homo sapiens_hsa002301.63035353
25Alzheimers disease_Homo sapiens_hsa050101.45933769
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41624351
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27336977
28Systemic lupus erythematosus_Homo sapiens_hsa053221.13194466
29p53 signaling pathway_Homo sapiens_hsa041151.10673523
30mRNA surveillance pathway_Homo sapiens_hsa030151.10434478
31Propanoate metabolism_Homo sapiens_hsa006401.05945907
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05028203
33Sulfur relay system_Homo sapiens_hsa041221.02929086
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01603223
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97096390
36Folate biosynthesis_Homo sapiens_hsa007900.96023727
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93324412
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93028712
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91088182
40Epstein-Barr virus infection_Homo sapiens_hsa051690.90238962
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.81998377
42Sulfur metabolism_Homo sapiens_hsa009200.76352869
43Glutathione metabolism_Homo sapiens_hsa004800.73873475
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72571449
45Butanoate metabolism_Homo sapiens_hsa006500.70130077
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.68982866
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.63717114
48Peroxisome_Homo sapiens_hsa041460.61414725
49Cardiac muscle contraction_Homo sapiens_hsa042600.57290530
50Metabolic pathways_Homo sapiens_hsa011000.55111008
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52172282
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51599185
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50557990
54Alcoholism_Homo sapiens_hsa050340.48315353
55Oocyte meiosis_Homo sapiens_hsa041140.47764066
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45213687
57Arachidonic acid metabolism_Homo sapiens_hsa005900.45085746
58Herpes simplex infection_Homo sapiens_hsa051680.45085664
59Biosynthesis of amino acids_Homo sapiens_hsa012300.44557785
60Pentose phosphate pathway_Homo sapiens_hsa000300.43332974
61Fatty acid metabolism_Homo sapiens_hsa012120.41997640
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41964795
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40990042
64Collecting duct acid secretion_Homo sapiens_hsa049660.40420823
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39342727
66Viral carcinogenesis_Homo sapiens_hsa052030.39189167
67Tryptophan metabolism_Homo sapiens_hsa003800.39029749
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37261665
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.36175158
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35619808
71N-Glycan biosynthesis_Homo sapiens_hsa005100.34916359
72Antigen processing and presentation_Homo sapiens_hsa046120.34637091
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34178213
74Chemical carcinogenesis_Homo sapiens_hsa052040.34110715
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32464067
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32375351
77HTLV-I infection_Homo sapiens_hsa051660.32284559
78Mineral absorption_Homo sapiens_hsa049780.32124574
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.31780255
80Steroid biosynthesis_Homo sapiens_hsa001000.30900038
81Vitamin digestion and absorption_Homo sapiens_hsa049770.30620999
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29988391
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28959890
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27530592
85Renin-angiotensin system_Homo sapiens_hsa046140.26388906
86Fatty acid elongation_Homo sapiens_hsa000620.26053487
87Vitamin B6 metabolism_Homo sapiens_hsa007500.25921937
88Primary immunodeficiency_Homo sapiens_hsa053400.25798162
89Selenocompound metabolism_Homo sapiens_hsa004500.23608024
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23317026
91Thyroid cancer_Homo sapiens_hsa052160.22672629
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22250764
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.22222465
94Fatty acid degradation_Homo sapiens_hsa000710.21574604
95Carbon metabolism_Homo sapiens_hsa012000.19703199
96Retinol metabolism_Homo sapiens_hsa008300.16975310
97Linoleic acid metabolism_Homo sapiens_hsa005910.16606341
98Regulation of autophagy_Homo sapiens_hsa041400.15426128
99Phototransduction_Homo sapiens_hsa047440.15184312
100Tyrosine metabolism_Homo sapiens_hsa003500.14485547
101Arginine and proline metabolism_Homo sapiens_hsa003300.13815490
102Galactose metabolism_Homo sapiens_hsa000520.13779690
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12433232
104Basal cell carcinoma_Homo sapiens_hsa052170.11966392
105TGF-beta signaling pathway_Homo sapiens_hsa043500.11755698
106beta-Alanine metabolism_Homo sapiens_hsa004100.10751103
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10483486
108Hematopoietic cell lineage_Homo sapiens_hsa046400.10033266
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.10017366
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09847757
111Phenylalanine metabolism_Homo sapiens_hsa003600.09747534
112Vibrio cholerae infection_Homo sapiens_hsa051100.09739502
113Legionellosis_Homo sapiens_hsa051340.09618528
114Lysine degradation_Homo sapiens_hsa003100.09581629
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09407260
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08206228
117Allograft rejection_Homo sapiens_hsa053300.05112638
118Other glycan degradation_Homo sapiens_hsa005110.04649563
119Autoimmune thyroid disease_Homo sapiens_hsa053200.03965953
120Colorectal cancer_Homo sapiens_hsa052100.03851495
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03582480
122Pyruvate metabolism_Homo sapiens_hsa006200.03262202
123Bladder cancer_Homo sapiens_hsa052190.02026176
124Fructose and mannose metabolism_Homo sapiens_hsa000510.01778450
125Sphingolipid metabolism_Homo sapiens_hsa006000.01556105
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.01173983
127Asthma_Homo sapiens_hsa053100.00703610
128alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0187842
129Measles_Homo sapiens_hsa05162-0.0132959
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072-0.0101571
131Apoptosis_Homo sapiens_hsa04210-0.0083137
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0067216

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