PTRHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.93412182
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.83560514
3protein neddylation (GO:0045116)5.66942626
4ATP synthesis coupled proton transport (GO:0015986)5.65733796
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.65733796
6ribosomal small subunit biogenesis (GO:0042274)5.24641040
7termination of RNA polymerase III transcription (GO:0006386)5.23804629
8transcription elongation from RNA polymerase III promoter (GO:0006385)5.23804629
9respiratory electron transport chain (GO:0022904)5.12388574
10electron transport chain (GO:0022900)4.98173246
11central nervous system myelination (GO:0022010)4.74920866
12axon ensheathment in central nervous system (GO:0032291)4.74920866
13viral transcription (GO:0019083)4.66208458
14cotranslational protein targeting to membrane (GO:0006613)4.56637207
15translational termination (GO:0006415)4.48994447
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47382885
17protein targeting to ER (GO:0045047)4.46504355
18proteasome assembly (GO:0043248)4.39462594
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.39144192
20NADH dehydrogenase complex assembly (GO:0010257)4.39144192
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39144192
22GTP biosynthetic process (GO:0006183)4.36885003
23chaperone-mediated protein transport (GO:0072321)4.30176912
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26070554
25protein complex biogenesis (GO:0070271)4.24895658
26protein localization to endoplasmic reticulum (GO:0070972)4.24198639
27ATP biosynthetic process (GO:0006754)4.01193534
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.96559171
297-methylguanosine mRNA capping (GO:0006370)3.93118901
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.93006153
31RNA capping (GO:0036260)3.86131720
327-methylguanosine RNA capping (GO:0009452)3.86131720
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.84345794
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.82671712
35ribosomal large subunit biogenesis (GO:0042273)3.72230639
36ribosomal small subunit assembly (GO:0000028)3.70228357
37mitochondrial respiratory chain complex assembly (GO:0033108)3.67010300
38maturation of SSU-rRNA (GO:0030490)3.66489492
39oxidative phosphorylation (GO:0006119)3.63625251
40cellular protein complex disassembly (GO:0043624)3.63198558
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.62181844
42UTP biosynthetic process (GO:0006228)3.60753561
43viral life cycle (GO:0019058)3.59081336
44inner mitochondrial membrane organization (GO:0007007)3.58111653
45translation (GO:0006412)3.54954080
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53553504
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53553504
48translational elongation (GO:0006414)3.53129563
49ribonucleoside triphosphate biosynthetic process (GO:0009201)3.52359192
50platelet dense granule organization (GO:0060155)3.49986613
51translational initiation (GO:0006413)3.43106945
52mRNA catabolic process (GO:0006402)3.42374755
53cullin deneddylation (GO:0010388)3.41540610
54respiratory chain complex IV assembly (GO:0008535)3.41479046
55water-soluble vitamin biosynthetic process (GO:0042364)3.40753656
56chromatin remodeling at centromere (GO:0031055)3.34146241
57transcription elongation from RNA polymerase I promoter (GO:0006362)3.33661391
58hydrogen transport (GO:0006818)3.31475659
59guanosine-containing compound biosynthetic process (GO:1901070)3.30772387
60intracellular protein transmembrane import (GO:0044743)3.29703731
61DNA deamination (GO:0045006)3.28847073
62protein-cofactor linkage (GO:0018065)3.28574080
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28502302
64rRNA modification (GO:0000154)3.25839789
65mitochondrial transport (GO:0006839)3.25176374
66nucleoside triphosphate biosynthetic process (GO:0009142)3.21589072
67pyrimidine nucleotide catabolic process (GO:0006244)3.19326299
68CENP-A containing nucleosome assembly (GO:0034080)3.17615959
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17254956
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17161501
71cytochrome complex assembly (GO:0017004)3.16556956
72spliceosomal snRNP assembly (GO:0000387)3.15901838
73deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.15094587
74regulation of mitochondrial translation (GO:0070129)3.14871587
75RNA catabolic process (GO:0006401)3.13639066
76signal peptide processing (GO:0006465)3.13471972
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12442786
78negative regulation of ligase activity (GO:0051352)3.12442786
79protein deneddylation (GO:0000338)3.10686246
80spliceosomal complex assembly (GO:0000245)3.09665619
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.09539886
82pseudouridine synthesis (GO:0001522)3.09142037
83protein targeting to mitochondrion (GO:0006626)3.08182855
84aerobic respiration (GO:0009060)3.05499129
85establishment of protein localization to mitochondrion (GO:0072655)3.02020638
86fatty acid elongation (GO:0030497)3.01060782
87CTP biosynthetic process (GO:0006241)3.00527905
88CTP metabolic process (GO:0046036)3.00527905
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98930606
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98930606
91transcription from RNA polymerase I promoter (GO:0006360)2.98774724
92presynaptic membrane assembly (GO:0097105)2.97634239
93protein targeting to membrane (GO:0006612)2.96672560
94hydrogen ion transmembrane transport (GO:1902600)2.95539204
95peptidyl-histidine modification (GO:0018202)2.94986865
96rRNA processing (GO:0006364)2.94982633
97establishment of viral latency (GO:0019043)2.94834677
98UTP metabolic process (GO:0046051)2.94656612
99long-chain fatty acid biosynthetic process (GO:0042759)2.94007450
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93798301
101regulation of cellular amino acid metabolic process (GO:0006521)2.93711926
102establishment of integrated proviral latency (GO:0075713)2.93597520
103protein complex disassembly (GO:0043241)2.92707296
104DNA damage response, detection of DNA damage (GO:0042769)2.92094706
105purine nucleoside monophosphate biosynthetic process (GO:0009127)2.91132493
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.91132493
107cellular component biogenesis (GO:0044085)2.89930425
108macromolecular complex disassembly (GO:0032984)2.89020863
109signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88505689
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.88505689
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88260534
112purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86867658
113termination of RNA polymerase I transcription (GO:0006363)2.85975232
114L-methionine salvage (GO:0071267)2.84957372
115L-methionine biosynthetic process (GO:0071265)2.84957372
116amino acid salvage (GO:0043102)2.84957372
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83417511
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82212375
119nucleoside diphosphate phosphorylation (GO:0006165)2.80072894
120purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78118056
121protein localization to mitochondrion (GO:0070585)2.76810348
122substantia nigra development (GO:0021762)2.76180289
123transcription elongation from RNA polymerase II promoter (GO:0006368)2.76045381
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76020241
125DNA-templated transcription, elongation (GO:0006354)2.75645225
126ribonucleoprotein complex biogenesis (GO:0022613)2.75520633
127proton transport (GO:0015992)2.75358555
128dopamine biosynthetic process (GO:0042416)2.73699828
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73289076
130DNA ligation (GO:0006266)2.72044077
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71211746
132signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71211746
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71211746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.93429308
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.29554222
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82826692
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.27985050
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.92428978
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33296157
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27221159
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.19021510
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12474649
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99943965
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99568337
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96458063
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83339473
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66421069
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.60288719
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52175401
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34128535
18VDR_23849224_ChIP-Seq_CD4+_Human2.30370760
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27243131
20ELK1_19687146_ChIP-ChIP_HELA_Human2.17642182
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08411919
22DCP1A_22483619_ChIP-Seq_HELA_Human2.07125159
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04476538
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.04270306
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91712206
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88900618
27VDR_22108803_ChIP-Seq_LS180_Human1.88656856
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.85517530
29FOXP3_21729870_ChIP-Seq_TREG_Human1.77380651
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76722783
31TTF2_22483619_ChIP-Seq_HELA_Human1.75946178
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70806911
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.69713214
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68995147
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67391168
36XRN2_22483619_ChIP-Seq_HELA_Human1.64231596
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64017393
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63899308
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48630295
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45185208
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43896015
42GBX2_23144817_ChIP-Seq_PC3_Human1.43810109
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43020111
44MYC_18940864_ChIP-ChIP_HL60_Human1.42471759
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.40548032
46FUS_26573619_Chip-Seq_HEK293_Human1.40390319
47IGF1R_20145208_ChIP-Seq_DFB_Human1.37031293
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36718936
49ZNF274_21170338_ChIP-Seq_K562_Hela1.35547026
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33655905
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.33281640
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31478007
53IRF1_19129219_ChIP-ChIP_H3396_Human1.30939726
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28728198
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26515991
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25862010
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22463255
58GABP_19822575_ChIP-Seq_HepG2_Human1.19935162
59TAF15_26573619_Chip-Seq_HEK293_Human1.19773865
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19689749
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17348693
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16233290
63EWS_26573619_Chip-Seq_HEK293_Human1.13063701
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12861931
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12219656
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10975841
67E2F7_22180533_ChIP-Seq_HELA_Human1.10031146
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09913963
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09665776
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09120945
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.09091879
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07448787
73EZH2_22144423_ChIP-Seq_EOC_Human1.07256814
74TP53_22573176_ChIP-Seq_HFKS_Human1.06634118
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06256398
76RNF2_27304074_Chip-Seq_NSC_Mouse1.05966837
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.04890079
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03976925
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03422872
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02896776
81KDM5A_27292631_Chip-Seq_BREAST_Human1.02656566
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02123202
83WT1_19549856_ChIP-ChIP_CCG9911_Human0.99878837
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.98991828
85ER_23166858_ChIP-Seq_MCF-7_Human0.97735930
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97159567
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96273139
88* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96054517
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95320106
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94800915
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.94500000
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94259548
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93941206
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93035029
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93035029
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93035029
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92831283
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92247259
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91960317
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90997945
101PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90594056
102P300_19829295_ChIP-Seq_ESCs_Human0.88505183
103STAT3_18555785_Chip-Seq_ESCs_Mouse0.88445162
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88264822
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87824688
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87778163
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86388334
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85444849
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83909585
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83623368
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83554200
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.81953464
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81901672
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.81403130
115P300_18555785_Chip-Seq_ESCs_Mouse0.81374060
116YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81322294
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80448283
118FOXP1_21924763_ChIP-Seq_HESCs_Human0.80192157
119CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79952876
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.79938097
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.79904939
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79876148
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79467301
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.79049515
125HTT_18923047_ChIP-ChIP_STHdh_Human0.78412950
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.78247428
127ERG_20517297_ChIP-Seq_VCAP_Human0.77857699
128AR_20517297_ChIP-Seq_VCAP_Human0.77715319
129NMYC_18555785_Chip-Seq_ESCs_Mouse0.76791790
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75835987
131EZH2_27304074_Chip-Seq_ESCs_Mouse0.75779527
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75642308
133NANOG_20526341_ChIP-Seq_ESCs_Human0.75457864
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75165147
135P53_22387025_ChIP-Seq_ESCs_Mouse0.75148187
136FOXA1_25329375_ChIP-Seq_VCAP_Human0.72299740
137FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72299740
138EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72202416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.78972247
2MP0003880_abnormal_central_pattern3.62099503
3MP0001529_abnormal_vocalization3.45665485
4MP0003136_yellow_coat_color3.33615551
5MP0001188_hyperpigmentation3.32030931
6MP0005409_darkened_coat_color3.23321680
7MP0001905_abnormal_dopamine_level3.08351345
8MP0003806_abnormal_nucleotide_metabolis2.71623975
9MP0002638_abnormal_pupillary_reflex2.45859685
10MP0002837_dystrophic_cardiac_calcinosis2.24613314
11MP0006292_abnormal_olfactory_placode2.19834677
12MP0000372_irregular_coat_pigmentation2.10686960
13MP0000920_abnormal_myelination2.09598432
14MP0002163_abnormal_gland_morphology2.09135898
15MP0002653_abnormal_ependyma_morphology2.02660823
16MP0003718_maternal_effect1.99284690
17MP0004381_abnormal_hair_follicle1.94459603
18MP0006276_abnormal_autonomic_nervous1.93267297
19MP0008877_abnormal_DNA_methylation1.86015698
20MP0003787_abnormal_imprinting1.83654582
21MP0004142_abnormal_muscle_tone1.83409390
22MP0005084_abnormal_gallbladder_morpholo1.77004095
23MP0008789_abnormal_olfactory_epithelium1.75370721
24MP0001986_abnormal_taste_sensitivity1.73421317
25MP0000015_abnormal_ear_pigmentation1.73367229
26MP0004742_abnormal_vestibular_system1.71735259
27MP0009697_abnormal_copulation1.70073239
28MP0008875_abnormal_xenobiotic_pharmacok1.67389561
29MP0008932_abnormal_embryonic_tissue1.66324798
30MP0001293_anophthalmia1.64640822
31MP0005379_endocrine/exocrine_gland_phen1.64018883
32MP0003123_paternal_imprinting1.62417650
33MP0008995_early_reproductive_senescence1.61997419
34MP0008057_abnormal_DNA_replication1.60200286
35MP0002277_abnormal_respiratory_mucosa1.51656576
36MP0005171_absent_coat_pigmentation1.51204489
37MP0002736_abnormal_nociception_after1.51195534
38MP0003011_delayed_dark_adaptation1.50439220
39MP0010030_abnormal_orbit_morphology1.49640432
40MP0002160_abnormal_reproductive_system1.49061156
41MP0000566_synostosis1.49017429
42MP0010386_abnormal_urinary_bladder1.48820161
43MP0001968_abnormal_touch/_nociception1.46167953
44MP0002734_abnormal_mechanical_nocicepti1.44536896
45MP0002272_abnormal_nervous_system1.43778258
46MP0004270_analgesia1.42566568
47MP0003724_increased_susceptibility_to1.42080378
48MP0001485_abnormal_pinna_reflex1.39571708
49MP0003693_abnormal_embryo_hatching1.36527514
50MP0003646_muscle_fatigue1.33925477
51MP0008260_abnormal_autophagy1.33095711
52MP0000778_abnormal_nervous_system1.29221064
53MP0004147_increased_porphyrin_level1.28643573
54MP0003121_genomic_imprinting1.27799797
55MP0006072_abnormal_retinal_apoptosis1.27336616
56MP0008872_abnormal_physiological_respon1.25994862
57MP0005389_reproductive_system_phenotype1.23798815
58MP0002822_catalepsy1.23490310
59MP0004957_abnormal_blastocyst_morpholog1.20109924
60MP0008058_abnormal_DNA_repair1.18152104
61MP0002234_abnormal_pharynx_morphology1.16507347
62MP0003315_abnormal_perineum_morphology1.15777477
63MP0002751_abnormal_autonomic_nervous1.15612416
64MP0003195_calcinosis1.12766429
65MP0001764_abnormal_homeostasis1.11443239
66MP0005394_taste/olfaction_phenotype1.11081590
67MP0005499_abnormal_olfactory_system1.11081590
68MP0005423_abnormal_somatic_nervous1.10968152
69MP0002064_seizures1.09449016
70MP0001919_abnormal_reproductive_system1.07598546
71MP0001486_abnormal_startle_reflex1.07520938
72MP0001970_abnormal_pain_threshold1.06279868
73MP0002148_abnormal_hypersensitivity_rea1.05656851
74MP0002210_abnormal_sex_determination1.04917012
75MP0002876_abnormal_thyroid_physiology1.03836927
76MP0001727_abnormal_embryo_implantation1.03084520
77MP0002090_abnormal_vision1.02138500
78MP0003186_abnormal_redox_activity1.01210840
79MP0005174_abnormal_tail_pigmentation0.99921109
80MP0005075_abnormal_melanosome_morpholog0.99720242
81MP0002938_white_spotting0.99692431
82MP0002095_abnormal_skin_pigmentation0.99387982
83MP0001984_abnormal_olfaction0.95766801
84MP0005408_hypopigmentation0.94330275
85MP0002102_abnormal_ear_morphology0.93763632
86MP0001286_abnormal_eye_development0.93007575
87MP0006036_abnormal_mitochondrial_physio0.92770427
88MP0001440_abnormal_grooming_behavior0.92035902
89MP0002572_abnormal_emotion/affect_behav0.91811760
90MP0005645_abnormal_hypothalamus_physiol0.91288657
91MP0001963_abnormal_hearing_physiology0.90233379
92MP0002735_abnormal_chemical_nociception0.90029625
93MP0002177_abnormal_outer_ear0.89763055
94MP0005646_abnormal_pituitary_gland0.89390577
95MP0003077_abnormal_cell_cycle0.89024845
96MP0009745_abnormal_behavioral_response0.88580755
97MP0002067_abnormal_sensory_capabilities0.86553230
98MP0006035_abnormal_mitochondrial_morpho0.86024839
99MP0005253_abnormal_eye_physiology0.85605543
100MP0005195_abnormal_posterior_eye0.85224489
101MP0005410_abnormal_fertilization0.84925367
102MP0000653_abnormal_sex_gland0.84485360
103MP0000631_abnormal_neuroendocrine_gland0.84223928
104MP0005000_abnormal_immune_tolerance0.83625110
105MP0001145_abnormal_male_reproductive0.83555102
106MP0003950_abnormal_plasma_membrane0.83403272
107MP0000049_abnormal_middle_ear0.82813925
108MP0008007_abnormal_cellular_replicative0.82761048
109MP0009333_abnormal_splenocyte_physiolog0.82622501
110MP0005671_abnormal_response_to0.82103539
111MP0003878_abnormal_ear_physiology0.81838676
112MP0005377_hearing/vestibular/ear_phenot0.81838676
113MP0001929_abnormal_gametogenesis0.81730838
114MP0000647_abnormal_sebaceous_gland0.81578598
115MP0003638_abnormal_response/metabolism_0.81007994
116MP0002733_abnormal_thermal_nociception0.80836190
117MP0004145_abnormal_muscle_electrophysio0.80736221
118MP0001346_abnormal_lacrimal_gland0.80140772
119MP0003634_abnormal_glial_cell0.79570642
120MP0005332_abnormal_amino_acid0.79198302
121MP0003937_abnormal_limbs/digits/tail_de0.79030117
122MP0002752_abnormal_somatic_nervous0.78639480
123MP0004043_abnormal_pH_regulation0.78119628
124MP0004019_abnormal_vitamin_homeostasis0.76340148
125MP0002229_neurodegeneration0.75126358
126MP0003567_abnormal_fetal_cardiomyocyte0.74659290
127MP0005551_abnormal_eye_electrophysiolog0.74452738
128MP0009250_abnormal_appendicular_skeleto0.73850717
129MP0000026_abnormal_inner_ear0.73834949
130MP0001324_abnormal_eye_pigmentation0.72904719
131MP0005386_behavior/neurological_phenoty0.72654770
132MP0004924_abnormal_behavior0.72654770
133MP0002282_abnormal_trachea_morphology0.72328923
134MP0002184_abnormal_innervation0.72138950
135MP0001835_abnormal_antigen_presentation0.71586573
136MP0010094_abnormal_chromosome_stability0.71109476
137MP0002933_joint_inflammation0.70133210
138MP0004133_heterotaxia0.69588449
139MP0002233_abnormal_nose_morphology0.69169896
140MP0003786_premature_aging0.67866153
141MP0001542_abnormal_bone_strength0.66847554
142MP0003938_abnormal_ear_development0.66061669
143MP0009046_muscle_twitch0.66034546
144MP0003635_abnormal_synaptic_transmissio0.65589253
145MP0002295_abnormal_pulmonary_circulatio0.65466452
146MP0000613_abnormal_salivary_gland0.64946363
147MP0002882_abnormal_neuron_morphology0.63383877
148MP0001177_atelectasis0.62998330

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.86050831
2Mitochondrial inheritance (HP:0001427)5.17390512
3Abnormal mitochondria in muscle tissue (HP:0008316)5.02359316
4Progressive macrocephaly (HP:0004481)4.92859728
5Increased hepatocellular lipid droplets (HP:0006565)4.49249400
6Acute encephalopathy (HP:0006846)4.44505765
7Parakeratosis (HP:0001036)4.21073821
8Increased CSF lactate (HP:0002490)4.14981191
9Hepatocellular necrosis (HP:0001404)4.09022404
10Renal Fanconi syndrome (HP:0001994)4.08287393
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.95293922
123-Methylglutaconic aciduria (HP:0003535)3.87290215
13Lipid accumulation in hepatocytes (HP:0006561)3.81581848
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.74567172
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.64064810
16Hepatic necrosis (HP:0002605)3.46853062
17Abnormality of glycolysis (HP:0004366)3.43813930
18Increased serum pyruvate (HP:0003542)3.43813930
19Exertional dyspnea (HP:0002875)3.38912950
20Leukodystrophy (HP:0002415)3.35596152
21Optic disc pallor (HP:0000543)3.25459256
22Abnormality of cells of the erythroid lineage (HP:0012130)3.13715892
23Cerebral hypomyelination (HP:0006808)3.02419366
24Pancreatic fibrosis (HP:0100732)2.98465660
25Respiratory failure (HP:0002878)2.97377443
26Macrocytic anemia (HP:0001972)2.95187110
27Abnormal number of erythroid precursors (HP:0012131)2.93800395
28Exercise intolerance (HP:0003546)2.91218041
29Hyperglycinemia (HP:0002154)2.89190806
30Reticulocytopenia (HP:0001896)2.85528915
31Aplastic anemia (HP:0001915)2.83367683
32Abnormality of midbrain morphology (HP:0002418)2.73936547
33Molar tooth sign on MRI (HP:0002419)2.73936547
34Increased intramyocellular lipid droplets (HP:0012240)2.71144544
35Congenital, generalized hypertrichosis (HP:0004540)2.69242638
36Hypothermia (HP:0002045)2.68412828
37Respiratory difficulties (HP:0002880)2.62486806
38Cerebral edema (HP:0002181)2.57688279
39Lethargy (HP:0001254)2.54951662
40Congenital ichthyosiform erythroderma (HP:0007431)2.54380946
41Increased serum lactate (HP:0002151)2.52620516
42Abnormal pupillary function (HP:0007686)2.50244744
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50199523
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50199523
45Abnormality of renal resorption (HP:0011038)2.49947321
46Sclerocornea (HP:0000647)2.46937905
47Aplasia/hypoplasia of the uterus (HP:0008684)2.37247277
48Birth length less than 3rd percentile (HP:0003561)2.36254843
49Colon cancer (HP:0003003)2.35306038
50Retinal dysplasia (HP:0007973)2.32860147
51Septo-optic dysplasia (HP:0100842)2.32506641
52Split foot (HP:0001839)2.29001479
53Breast hypoplasia (HP:0003187)2.28385245
54Lactic acidosis (HP:0003128)2.26562298
55Methylmalonic aciduria (HP:0012120)2.25906377
56Sensory axonal neuropathy (HP:0003390)2.22463750
57Generalized aminoaciduria (HP:0002909)2.19800185
58Type I transferrin isoform profile (HP:0003642)2.19379148
59Methylmalonic acidemia (HP:0002912)2.19282274
60Pallor (HP:0000980)2.18283850
61Abnormal hemoglobin (HP:0011902)2.17129190
62Limb dystonia (HP:0002451)2.15630203
63Hyperphosphaturia (HP:0003109)2.15292109
64Nephronophthisis (HP:0000090)2.12858299
65Male pseudohermaphroditism (HP:0000037)2.10260134
66Hypoplastic pelvis (HP:0008839)2.09389989
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08442329
68Hyperglycinuria (HP:0003108)2.07273444
69Neuroendocrine neoplasm (HP:0100634)2.04569622
70Adrenal hypoplasia (HP:0000835)2.00563601
71Abnormality of serum amino acid levels (HP:0003112)2.00382454
72Myokymia (HP:0002411)1.99625799
73Pancytopenia (HP:0001876)1.98734385
74Increased muscle lipid content (HP:0009058)1.97944144
75Medial flaring of the eyebrow (HP:0010747)1.96469023
76X-linked dominant inheritance (HP:0001423)1.94442732
77Abnormality of serine family amino acid metabolism (HP:0010894)1.94427816
78Abnormality of glycine metabolism (HP:0010895)1.94427816
79Neurofibrillary tangles (HP:0002185)1.94008684
80Delusions (HP:0000746)1.91675419
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89633072
82Blindness (HP:0000618)1.88498426
83Microvesicular hepatic steatosis (HP:0001414)1.86719867
84Anencephaly (HP:0002323)1.86102997
85Irregular epiphyses (HP:0010582)1.84410673
86Concave nail (HP:0001598)1.84234252
87Patchy hypopigmentation of hair (HP:0011365)1.83580101
88Abnormality of the septum pellucidum (HP:0007375)1.82445504
89Poor head control (HP:0002421)1.82420782
90Degeneration of the lateral corticospinal tracts (HP:0002314)1.81659475
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81659475
92Absent thumb (HP:0009777)1.79728831
93Rib fusion (HP:0000902)1.79530295
94Degeneration of anterior horn cells (HP:0002398)1.78972623
95Abnormality of the anterior horn cell (HP:0006802)1.78972623
96Congenital stationary night blindness (HP:0007642)1.78134731
97Oral leukoplakia (HP:0002745)1.77692502
98Hypoplasia of the uterus (HP:0000013)1.77062218
99Bile duct proliferation (HP:0001408)1.75504470
100Abnormal biliary tract physiology (HP:0012439)1.75504470
101Type II lissencephaly (HP:0007260)1.75221865
102True hermaphroditism (HP:0010459)1.74703260
103Abnormality of the axillary hair (HP:0100134)1.74701954
104Abnormality of secondary sexual hair (HP:0009888)1.74701954
105CNS demyelination (HP:0007305)1.73616221
106Type 2 muscle fiber atrophy (HP:0003554)1.73214106
107Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72904548
108Dicarboxylic aciduria (HP:0003215)1.72904548
109Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72222593
110Abnormality of placental membranes (HP:0011409)1.71991996
111Amniotic constriction ring (HP:0009775)1.71991996
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.71855265
113Occipital encephalocele (HP:0002085)1.71026373
114Abnormality of the labia minora (HP:0012880)1.70628953
115Abnormal rod and cone electroretinograms (HP:0008323)1.70614372
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70565659
117CNS hypomyelination (HP:0003429)1.70326094
118Microretrognathia (HP:0000308)1.70215182
119Emotional lability (HP:0000712)1.70019651
120Anophthalmia (HP:0000528)1.69955937
121Triphalangeal thumb (HP:0001199)1.69526619
122Depressed nasal ridge (HP:0000457)1.69454400
123Pheochromocytoma (HP:0002666)1.68782550
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68653946
125Abnormal protein N-linked glycosylation (HP:0012347)1.68653946
126Abnormal protein glycosylation (HP:0012346)1.68653946
127Abnormal glycosylation (HP:0012345)1.68653946
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68562611
129Abolished electroretinogram (ERG) (HP:0000550)1.68385564
130Abnormal hair whorl (HP:0010721)1.66942556
131Abnormal urine phosphate concentration (HP:0012599)1.66712183
132Hepatosplenomegaly (HP:0001433)1.66327012
133Spastic paraparesis (HP:0002313)1.66103251
134Glycosuria (HP:0003076)1.65926876
135Abnormality of urine glucose concentration (HP:0011016)1.65926876
136Absent septum pellucidum (HP:0001331)1.65478290
137Abnormality of the renal medulla (HP:0100957)1.64852909
138Muscle fiber atrophy (HP:0100295)1.64385787
139Abnormality of dental color (HP:0011073)1.63861742
140Abnormal respiratory epithelium morphology (HP:0012253)1.63831798
141Abnormal respiratory motile cilium morphology (HP:0005938)1.63831798
142Abnormal respiratory motile cilium physiology (HP:0012261)1.62742548
143Nasolacrimal duct obstruction (HP:0000579)1.62420305
144Stenosis of the external auditory canal (HP:0000402)1.62389081
145Pancreatic cysts (HP:0001737)1.59283803
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59176954
147Absent epiphyses (HP:0010577)1.59176954
148Secondary amenorrhea (HP:0000869)1.56962730
149Carpal bone hypoplasia (HP:0001498)1.55666711
150Hypomagnesemia (HP:0002917)1.54474163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.39449688
2NME13.73206877
3PBK3.22229989
4BUB13.11702119
5TLK13.02129749
6NME22.94117162
7STK162.92988212
8CDK192.70294615
9STK392.68414098
10CASK2.66215293
11BCKDK2.64178652
12IRAK22.44868716
13CDC72.07022121
14MST42.01230648
15BCR1.94827621
16TAF11.93799326
17PNCK1.93558285
18VRK11.90665843
19BMPR1B1.88509974
20PLK41.82505436
21OXSR11.75786973
22WNK31.72194678
23IRAK41.67182254
24MAP4K21.52952326
25IRAK11.50069219
26ARAF1.48297129
27DYRK21.44907543
28LIMK11.41504725
29TESK21.41160494
30WEE11.40637189
31PIM21.34369851
32INSRR1.33842977
33EIF2AK11.33732647
34GRK11.32410167
35TRIM281.32395372
36IRAK31.30843980
37MKNK21.30701380
38MAPKAPK51.30519488
39TNIK1.27311296
40SRPK11.27096705
41NEK11.24511156
42BMPR21.18472557
43MKNK11.17618514
44CLK11.12642418
45PLK21.11431889
46CSNK1G31.08593889
47WNK41.07499750
48EIF2AK31.04357902
49ABL21.03995976
50PKN11.00780448
51BLK1.00327731
52UHMK10.98172668
53FES0.97169408
54MAP3K120.95616385
55ZAK0.94964502
56ILK0.90918176
57BRAF0.89990417
58NEK60.85244955
59ADRBK20.83935598
60AURKB0.83295929
61FGR0.82603091
62MAPK150.82367210
63KDR0.80083062
64RPS6KA50.79714902
65AURKA0.79622885
66CSNK1G10.79290871
67TIE10.78467041
68CHEK20.78149770
69EIF2AK20.77296522
70DAPK30.75804086
71CAMK2B0.74863760
72PASK0.73412335
73EPHB10.73205977
74GRK70.71271265
75DYRK30.70189029
76LRRK20.70057358
77PDK20.66351566
78GRK50.65800770
79PRKCI0.65599135
80MYLK0.65323629
81TTK0.64661891
82PLK30.64491652
83DAPK10.64027655
84DYRK1A0.63851442
85CDK140.63234885
86CCNB10.62721508
87YES10.61068672
88PINK10.60864647
89CSNK1A1L0.58514947
90MUSK0.58243670
91ATR0.58115652
92ACVR1B0.55910773
93CSNK1G20.54711818
94ADRBK10.54423212
95MAPK130.52045169
96TSSK60.51721773
97NLK0.51645581
98TEC0.50582905
99PRKCG0.50263955
100CDK80.49981016
101IKBKB0.49799650
102CAMK2D0.49413988
103CAMK2A0.48845337
104CDK11A0.48817358
105CSNK2A10.48354636
106MARK10.48344775
107CSNK2A20.47736485
108ROCK20.46963567
109MET0.46623480
110MAP3K110.46594208
111CDK30.45504836
112MAP2K70.44659256
113CDK180.44534637
114BRSK20.43443543
115TXK0.42866120
116STK40.42297835
117OBSCN0.42002668
118CDK150.41547419
119BRSK10.41299643
120LYN0.40830159
121RIPK40.40711560
122MINK10.39936460
123LCK0.38435813
124PRKACA0.38104590
125CAMK2G0.37222836
126TGFBR10.36634489
127PAK10.36561528
128AKT30.34354993
129PRKCQ0.34255305
130CSNK1A10.33569204
131EPHB20.33472969
132FRK0.33299713
133CDK70.33137047
134NUAK10.33128568
135PRKCE0.32652455
136SIK30.31766470
137PLK10.31596813
138STK30.31338117
139PIM10.31133468

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.78757752
2Ribosome_Homo sapiens_hsa030104.53264197
3Parkinsons disease_Homo sapiens_hsa050124.06670144
4RNA polymerase_Homo sapiens_hsa030203.98035227
5Protein export_Homo sapiens_hsa030603.94181883
6Proteasome_Homo sapiens_hsa030503.59716530
7Huntingtons disease_Homo sapiens_hsa050163.04137574
8Alzheimers disease_Homo sapiens_hsa050103.02534349
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57009892
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.46622328
11Steroid biosynthesis_Homo sapiens_hsa001002.02629541
12Pyrimidine metabolism_Homo sapiens_hsa002401.96947173
13Homologous recombination_Homo sapiens_hsa034401.96001600
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90049912
15Basal transcription factors_Homo sapiens_hsa030221.83827349
16Spliceosome_Homo sapiens_hsa030401.59606460
17Sulfur relay system_Homo sapiens_hsa041221.57438815
18Cardiac muscle contraction_Homo sapiens_hsa042601.56367969
19Ether lipid metabolism_Homo sapiens_hsa005651.53784461
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46594625
21Fatty acid elongation_Homo sapiens_hsa000621.44957216
22One carbon pool by folate_Homo sapiens_hsa006701.44419733
23DNA replication_Homo sapiens_hsa030301.41577806
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40155425
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38401486
26Sulfur metabolism_Homo sapiens_hsa009201.37540875
27Nucleotide excision repair_Homo sapiens_hsa034201.36270441
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35921838
29Mismatch repair_Homo sapiens_hsa034301.35242959
30Collecting duct acid secretion_Homo sapiens_hsa049661.31725356
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29049784
32Sphingolipid metabolism_Homo sapiens_hsa006001.25791126
33Propanoate metabolism_Homo sapiens_hsa006401.20408542
34Purine metabolism_Homo sapiens_hsa002301.15432752
35Vibrio cholerae infection_Homo sapiens_hsa051101.06122396
36Pyruvate metabolism_Homo sapiens_hsa006201.05820860
37Non-homologous end-joining_Homo sapiens_hsa034501.05381448
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02024831
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98352848
40Linoleic acid metabolism_Homo sapiens_hsa005910.97350280
41Rheumatoid arthritis_Homo sapiens_hsa053230.96962834
42RNA degradation_Homo sapiens_hsa030180.94365174
43RNA transport_Homo sapiens_hsa030130.91261552
44Arachidonic acid metabolism_Homo sapiens_hsa005900.86768400
45Peroxisome_Homo sapiens_hsa041460.86094038
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86058661
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.84760123
48Base excision repair_Homo sapiens_hsa034100.82322882
49Fanconi anemia pathway_Homo sapiens_hsa034600.77507970
50Butanoate metabolism_Homo sapiens_hsa006500.77242193
51Allograft rejection_Homo sapiens_hsa053300.76417582
52Serotonergic synapse_Homo sapiens_hsa047260.74872816
53Nitrogen metabolism_Homo sapiens_hsa009100.70795976
54Autoimmune thyroid disease_Homo sapiens_hsa053200.69394896
55Epstein-Barr virus infection_Homo sapiens_hsa051690.69135657
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68873815
57Asthma_Homo sapiens_hsa053100.68628854
58Folate biosynthesis_Homo sapiens_hsa007900.68550119
59Graft-versus-host disease_Homo sapiens_hsa053320.66865533
60Phototransduction_Homo sapiens_hsa047440.65874442
61Metabolic pathways_Homo sapiens_hsa011000.65332367
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63677972
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63633796
64Chemical carcinogenesis_Homo sapiens_hsa052040.62249661
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.60811039
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59281642
67Phagosome_Homo sapiens_hsa041450.58305713
68Regulation of autophagy_Homo sapiens_hsa041400.57931468
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57802141
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55592371
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55024889
72Long-term depression_Homo sapiens_hsa047300.54242920
73Cell cycle_Homo sapiens_hsa041100.53998149
74Selenocompound metabolism_Homo sapiens_hsa004500.53138913
75Tryptophan metabolism_Homo sapiens_hsa003800.52467480
76Vitamin B6 metabolism_Homo sapiens_hsa007500.51791593
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.50983382
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49001905
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47953902
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45450515
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44967023
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.43706706
83Carbon metabolism_Homo sapiens_hsa012000.43166353
84Caffeine metabolism_Homo sapiens_hsa002320.41017116
85Glutathione metabolism_Homo sapiens_hsa004800.40936114
86Vitamin digestion and absorption_Homo sapiens_hsa049770.40077708
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38536100
88Retinol metabolism_Homo sapiens_hsa008300.38213496
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37481628
90Fatty acid degradation_Homo sapiens_hsa000710.36434824
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36144011
92Alcoholism_Homo sapiens_hsa050340.35645379
93Nicotine addiction_Homo sapiens_hsa050330.34647501
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34464524
95Type I diabetes mellitus_Homo sapiens_hsa049400.32957784
96Tyrosine metabolism_Homo sapiens_hsa003500.32436491
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.30948179
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30925641
99Cocaine addiction_Homo sapiens_hsa050300.30647185
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29950252
101beta-Alanine metabolism_Homo sapiens_hsa004100.29892501
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29768631
103Histidine metabolism_Homo sapiens_hsa003400.29046898
104Fatty acid metabolism_Homo sapiens_hsa012120.28555338
105Axon guidance_Homo sapiens_hsa043600.28215917
106Biosynthesis of amino acids_Homo sapiens_hsa012300.27906188
107Olfactory transduction_Homo sapiens_hsa047400.27231854
108Pertussis_Homo sapiens_hsa051330.26968124
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26614456
110Fat digestion and absorption_Homo sapiens_hsa049750.26494089
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26194208
112Oocyte meiosis_Homo sapiens_hsa041140.25239281
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.25145124
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.24722759
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24489332
116African trypanosomiasis_Homo sapiens_hsa051430.24176343
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24095213
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23152981
119Systemic lupus erythematosus_Homo sapiens_hsa053220.21941718
120Hematopoietic cell lineage_Homo sapiens_hsa046400.21909378
121Other glycan degradation_Homo sapiens_hsa005110.21641551
122mRNA surveillance pathway_Homo sapiens_hsa030150.21217960
123Synaptic vesicle cycle_Homo sapiens_hsa047210.20078469
124Primary immunodeficiency_Homo sapiens_hsa053400.18793901
125Dopaminergic synapse_Homo sapiens_hsa047280.17243128
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17061884
127Malaria_Homo sapiens_hsa051440.15815914
128Phenylalanine metabolism_Homo sapiens_hsa003600.15781461
129Taste transduction_Homo sapiens_hsa047420.15265105
130Shigellosis_Homo sapiens_hsa051310.15105227
131Glutamatergic synapse_Homo sapiens_hsa047240.13950731
132Amphetamine addiction_Homo sapiens_hsa050310.12329325
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.11544374
134p53 signaling pathway_Homo sapiens_hsa041150.09556547
135Arginine and proline metabolism_Homo sapiens_hsa003300.08627934
136Salmonella infection_Homo sapiens_hsa051320.07975066
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06570740
138GABAergic synapse_Homo sapiens_hsa047270.05486478

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