PTTG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.93812409
2attachment of spindle microtubules to kinetochore (GO:0008608)6.06108443
3metaphase plate congression (GO:0051310)5.93802151
4establishment of chromosome localization (GO:0051303)5.41123752
5meiotic cell cycle (GO:0051321)5.36033939
6regulation of DNA methylation (GO:0044030)5.32007884
7piRNA metabolic process (GO:0034587)5.26886233
8kinetochore assembly (GO:0051382)5.22189035
9CENP-A containing nucleosome assembly (GO:0034080)5.04102000
10mitotic chromosome condensation (GO:0007076)5.03709993
11kinetochore organization (GO:0051383)4.95664571
12regulation of female gonad development (GO:2000194)4.91247265
13centriole replication (GO:0007099)4.87945660
14meiotic chromosome segregation (GO:0045132)4.84017124
15negative regulation of meiosis (GO:0045835)4.81499002
16chromatin remodeling at centromere (GO:0031055)4.79188781
17maturation of 5.8S rRNA (GO:0000460)4.77408615
18protein localization to kinetochore (GO:0034501)4.72126761
19mitotic sister chromatid segregation (GO:0000070)4.64242823
20regulation of exit from mitosis (GO:0007096)4.63007365
21protein localization to chromosome, centromeric region (GO:0071459)4.51729276
22female gamete generation (GO:0007292)4.39295471
23histone exchange (GO:0043486)4.37121535
24regulation of meiosis (GO:0040020)4.36422401
25synapsis (GO:0007129)4.35549566
26regulation of cell maturation (GO:1903429)4.32253670
27DNA replication-independent nucleosome assembly (GO:0006336)4.29409857
28DNA replication-independent nucleosome organization (GO:0034724)4.29409857
29histone H2A monoubiquitination (GO:0035518)4.29305135
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.27675387
31protein K6-linked ubiquitination (GO:0085020)4.23913117
32DNA replication checkpoint (GO:0000076)4.19954653
33regulation of spindle organization (GO:0090224)4.13480797
34positive regulation of chromosome segregation (GO:0051984)4.12020896
35retinal cone cell development (GO:0046549)4.07232298
36spindle checkpoint (GO:0031577)4.05228654
37regulation of histone H3-K9 methylation (GO:0051570)4.01760708
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.00352410
39positive regulation of histone H3-K4 methylation (GO:0051571)3.99813922
40regulation of mitotic spindle organization (GO:0060236)3.94157980
41regulation of sister chromatid cohesion (GO:0007063)3.91656879
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.90479584
43negative regulation of meiotic cell cycle (GO:0051447)3.87430010
44telomere maintenance via semi-conservative replication (GO:0032201)3.87002955
45DNA methylation involved in gamete generation (GO:0043046)3.81834159
46positive regulation of gastrulation (GO:2000543)3.81028693
47chromosome organization involved in meiosis (GO:0070192)3.79835317
48DNA strand elongation involved in DNA replication (GO:0006271)3.78831905
49histone H2A ubiquitination (GO:0033522)3.76395893
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75812879
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.75084049
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.75084049
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.75084049
54* chromosome segregation (GO:0007059)3.74272336
55male meiosis (GO:0007140)3.72685461
56protein localization to chromosome (GO:0034502)3.71784979
57oocyte maturation (GO:0001556)3.70420606
58primitive streak formation (GO:0090009)3.69993093
59DNA strand elongation (GO:0022616)3.69983965
60mitotic nuclear envelope disassembly (GO:0007077)3.66716741
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.63979052
62sister chromatid segregation (GO:0000819)3.62070000
63mitotic spindle checkpoint (GO:0071174)3.61648882
64regulation of chromosome segregation (GO:0051983)3.61433103
65chaperone-mediated protein transport (GO:0072321)3.56196276
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.55322963
67negative regulation of DNA-templated transcription, elongation (GO:0032785)3.55322963
68regulation of histone H3-K27 methylation (GO:0061085)3.51573249
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.50996127
70negative regulation of chromosome segregation (GO:0051985)3.50890889
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.49299967
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46993298
73negative regulation of sister chromatid segregation (GO:0033046)3.46993298
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.46993298
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46993298
76regulation of meiotic cell cycle (GO:0051445)3.45410075
77mitotic spindle assembly checkpoint (GO:0007094)3.39941175
78negative regulation of nuclear division (GO:0051784)3.38169493
79spindle assembly checkpoint (GO:0071173)3.38080953
80regulation of mitotic sister chromatid separation (GO:0010965)3.37982372
81regulation of mitotic sister chromatid segregation (GO:0033047)3.37982372
82regulation of sister chromatid segregation (GO:0033045)3.37982372
83gene silencing by RNA (GO:0031047)3.37304254
847-methylguanosine mRNA capping (GO:0006370)3.36804601
85synaptonemal complex assembly (GO:0007130)3.36489847
86centriole assembly (GO:0098534)3.36444504
87negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.35779146
88chromatin assembly or disassembly (GO:0006333)3.35758704
89proteasome assembly (GO:0043248)3.34800571
90telomere maintenance via recombination (GO:0000722)3.34772236
91translesion synthesis (GO:0019985)3.34096880
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33230119
93mitotic recombination (GO:0006312)3.33045247
94nuclear envelope disassembly (GO:0051081)3.32881793
95membrane disassembly (GO:0030397)3.32881793
967-methylguanosine RNA capping (GO:0009452)3.32778388
97RNA capping (GO:0036260)3.32778388
98DNA damage induced protein phosphorylation (GO:0006975)3.32450974
99negative regulation of histone methylation (GO:0031061)3.31984566
100mitotic G2/M transition checkpoint (GO:0044818)3.31816897
101negative regulation of cell division (GO:0051782)3.28155205
102rRNA modification (GO:0000154)3.22414517
103meiotic nuclear division (GO:0007126)3.22213146
104neuron fate determination (GO:0048664)3.21691803
105chromosome condensation (GO:0030261)3.20281311
106histone-serine phosphorylation (GO:0035404)3.19830197
107regulation of mitotic spindle checkpoint (GO:1903504)3.16346656
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16346656
109meiotic cell cycle process (GO:1903046)3.15343824
110male meiosis I (GO:0007141)3.13961006
111negative regulation of mitosis (GO:0045839)3.13085383
112positive regulation of megakaryocyte differentiation (GO:0045654)3.07517581
113regulation of spindle checkpoint (GO:0090231)3.06940778
114* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06764268
115DNA ligation (GO:0006266)3.06067946
116replication fork processing (GO:0031297)3.04234860
117synaptonemal complex organization (GO:0070193)2.97708733
118base-excision repair, AP site formation (GO:0006285)2.96485782
119spermatid nucleus differentiation (GO:0007289)2.96043373
120meiosis I (GO:0007127)2.95769272
121establishment of integrated proviral latency (GO:0075713)2.95661305
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93711512
123DNA replication-dependent nucleosome organization (GO:0034723)2.93695346
124DNA replication-dependent nucleosome assembly (GO:0006335)2.93695346
125DNA damage response, signal transduction resulting in transcription (GO:0042772)2.92531326
126ribosome assembly (GO:0042255)2.92024877
127regulation of meiosis I (GO:0060631)2.90053411
128DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.89659234
129transcription elongation from RNA polymerase II promoter (GO:0006368)2.89454824
130DNA replication initiation (GO:0006270)2.88419606
131notochord development (GO:0030903)2.87038642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.78481395
2E2F7_22180533_ChIP-Seq_HELA_Human5.64269576
3EZH2_22144423_ChIP-Seq_EOC_Human5.04075949
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.70558068
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.31307037
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.15778559
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97896346
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.74549022
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.22782249
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20503016
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.12053886
12AR_21909140_ChIP-Seq_LNCAP_Human3.00870111
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98596222
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.91892628
15KAP1_22055183_ChIP-Seq_ESCs_Mouse2.88812818
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71129619
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68079545
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.53026690
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.53026690
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.53026690
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.52330363
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.42913350
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39357073
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26713270
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.22570369
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20941375
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09624602
28VDR_23849224_ChIP-Seq_CD4+_Human2.04608673
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93911782
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90687587
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87828457
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81799876
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80637635
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.77542119
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75365543
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74003592
37MYC_18940864_ChIP-ChIP_HL60_Human1.73439471
38DCP1A_22483619_ChIP-Seq_HELA_Human1.68054882
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66408664
40* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65514426
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.65022640
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.64489064
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.59668768
44GABP_19822575_ChIP-Seq_HepG2_Human1.59360904
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57867678
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.57504523
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55842268
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53192275
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52487627
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.49048490
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48706419
52FOXP3_21729870_ChIP-Seq_TREG_Human1.44076867
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43841180
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41779969
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37983804
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.37385554
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36877737
58ELK1_19687146_ChIP-ChIP_HELA_Human1.31072301
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30235682
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29284352
61XRN2_22483619_ChIP-Seq_HELA_Human1.29160889
62TTF2_22483619_ChIP-Seq_HELA_Human1.28845821
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28704836
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28528858
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.28030929
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.27002559
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24414069
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.17525552
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15664652
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13037501
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12165425
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05765152
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.02249533
74KDM5A_27292631_Chip-Seq_BREAST_Human1.02027547
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00764463
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00522648
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97925592
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97328421
79VDR_22108803_ChIP-Seq_LS180_Human0.97262626
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95352333
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95197604
82HTT_18923047_ChIP-ChIP_STHdh_Human0.94616066
83GATA3_21867929_ChIP-Seq_TH1_Mouse0.94280579
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93966713
85FUS_26573619_Chip-Seq_HEK293_Human0.93550311
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89860683
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89495492
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89116853
89EWS_26573619_Chip-Seq_HEK293_Human0.88909639
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88504588
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83563445
92ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83530617
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.83404203
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82524582
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81796350
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81165535
97RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81071389
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.80205994
99RNF2_27304074_Chip-Seq_NSC_Mouse0.79508208
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79492800
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79303919
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79277484
103NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78765884
104KAP1_27257070_Chip-Seq_ESCs_Mouse0.78317246
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76944360
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.76288744
107IRF1_19129219_ChIP-ChIP_H3396_Human0.75753920
108STAT1_17558387_ChIP-Seq_HELA_Human0.75609109
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73801505
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72894988
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71777343
112NANOG_20526341_ChIP-Seq_ESCs_Human0.71424540
113NANOG_18692474_ChIP-Seq_MESCs_Mouse0.71061758
114FOXH1_21741376_ChIP-Seq_EPCs_Human0.70620658
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70444756
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.70017989
117NANOG_18692474_ChIP-Seq_MEFs_Mouse0.69784202
118* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.69601055
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68924748
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68393012
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67815739
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67005386
123ERG_20517297_ChIP-Seq_VCAP_Human0.66835744
124* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.66636051
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.66240461
126ELF1_17652178_ChIP-ChIP_JURKAT_Human0.65244869
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.64471198
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63873145
129* SALL4_22934838_ChIP-ChIP_CD34+_Human0.63171514
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.63017671
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.62562963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.42221172
2MP0003693_abnormal_embryo_hatching5.22606443
3MP0008789_abnormal_olfactory_epithelium4.39021396
4MP0003111_abnormal_nucleus_morphology4.03292287
5MP0003646_muscle_fatigue3.97303068
6MP0010094_abnormal_chromosome_stability3.96680152
7MP0005451_abnormal_body_composition3.81890393
8MP0005394_taste/olfaction_phenotype3.67158774
9MP0005499_abnormal_olfactory_system3.67158774
10MP0004957_abnormal_blastocyst_morpholog3.64492412
11* MP0003077_abnormal_cell_cycle3.53979739
12MP0008877_abnormal_DNA_methylation3.26897595
13MP0006292_abnormal_olfactory_placode2.69756134
14MP0005395_other_phenotype2.65023414
15MP0002234_abnormal_pharynx_morphology2.56451379
16MP0002653_abnormal_ependyma_morphology2.50370618
17MP0002102_abnormal_ear_morphology2.48136189
18MP0008932_abnormal_embryonic_tissue2.46934674
19MP0008057_abnormal_DNA_replication2.42230830
20MP0008058_abnormal_DNA_repair2.41057202
21MP0008007_abnormal_cellular_replicative2.38950148
22MP0001119_abnormal_female_reproductive2.34499797
23MP0001293_anophthalmia2.21117501
24MP0003136_yellow_coat_color2.20249603
25MP0005408_hypopigmentation2.16054142
26MP0003950_abnormal_plasma_membrane2.09408441
27MP0001929_abnormal_gametogenesis2.03999741
28* MP0002210_abnormal_sex_determination1.95732599
29* MP0003699_abnormal_female_reproductive1.94275984
30MP0003315_abnormal_perineum_morphology1.89725365
31* MP0000653_abnormal_sex_gland1.81478151
32MP0002139_abnormal_hepatobiliary_system1.72055533
33MP0010234_abnormal_vibrissa_follicle1.71991346
34MP0003937_abnormal_limbs/digits/tail_de1.66335109
35MP0009379_abnormal_foot_pigmentation1.50978059
36MP0008004_abnormal_stomach_pH1.48179180
37MP0005410_abnormal_fertilization1.46172474
38MP0002233_abnormal_nose_morphology1.42644141
39MP0005360_urolithiasis1.39416901
40* MP0000350_abnormal_cell_proliferation1.38552270
41MP0001529_abnormal_vocalization1.37558523
42MP0001730_embryonic_growth_arrest1.37165223
43MP0008260_abnormal_autophagy1.36586302
44MP0009697_abnormal_copulation1.36425449
45* MP0001145_abnormal_male_reproductive1.36291733
46MP0003123_paternal_imprinting1.35590278
47MP0003786_premature_aging1.35276196
48MP0003186_abnormal_redox_activity1.28168235
49MP0000762_abnormal_tongue_morphology1.27395086
50MP0002138_abnormal_hepatobiliary_system1.25422061
51MP0001984_abnormal_olfaction1.24281187
52MP0002085_abnormal_embryonic_tissue1.20724590
53MP0003121_genomic_imprinting1.18996163
54* MP0002161_abnormal_fertility/fecundity1.18033790
55MP0000372_irregular_coat_pigmentation1.17123286
56MP0002019_abnormal_tumor_incidence1.09672676
57MP0005646_abnormal_pituitary_gland1.07841306
58MP0001697_abnormal_embryo_size1.05355611
59MP0001672_abnormal_embryogenesis/_devel1.05186458
60MP0005380_embryogenesis_phenotype1.05186458
61MP0003787_abnormal_imprinting1.04864625
62MP0000631_abnormal_neuroendocrine_gland1.03238205
63MP0001485_abnormal_pinna_reflex1.03148852
64MP0002249_abnormal_larynx_morphology1.01973027
65MP0000566_synostosis1.00744805
66MP0000049_abnormal_middle_ear1.00683323
67MP0003890_abnormal_embryonic-extraembry0.99904580
68MP0002132_abnormal_respiratory_system0.98970025
69MP0005389_reproductive_system_phenotype0.97781344
70MP0003119_abnormal_digestive_system0.97416222
71MP0005171_absent_coat_pigmentation0.93796721
72MP0001905_abnormal_dopamine_level0.93426632
73MP0003878_abnormal_ear_physiology0.91700230
74MP0005377_hearing/vestibular/ear_phenot0.91700230
75MP0003698_abnormal_male_reproductive0.91575811
76MP0001919_abnormal_reproductive_system0.91093049
77MP0002277_abnormal_respiratory_mucosa0.88856914
78MP0000313_abnormal_cell_death0.85932773
79MP0005647_abnormal_sex_gland0.85343488
80MP0002163_abnormal_gland_morphology0.84485676
81MP0003763_abnormal_thymus_physiology0.84379442
82MP0000579_abnormal_nail_morphology0.82961187
83MP0001324_abnormal_eye_pigmentation0.82032771
84MP0002084_abnormal_developmental_patter0.81778599
85MP0003806_abnormal_nucleotide_metabolis0.79506242
86MP0005310_abnormal_salivary_gland0.78713202
87MP0004782_abnormal_surfactant_physiolog0.78496054
88MP0003941_abnormal_skin_development0.78323534
89MP0006072_abnormal_retinal_apoptosis0.76937339
90MP0000490_abnormal_crypts_of0.76341716
91MP0009333_abnormal_splenocyte_physiolog0.75646300
92MP0002638_abnormal_pupillary_reflex0.73208645
93MP0001346_abnormal_lacrimal_gland0.72974690
94MP0002080_prenatal_lethality0.70521556
95MP0005075_abnormal_melanosome_morpholog0.70419903
96MP0002095_abnormal_skin_pigmentation0.69386643
97MP0000613_abnormal_salivary_gland0.69160539
98MP0000427_abnormal_hair_cycle0.68359244
99MP0002396_abnormal_hematopoietic_system0.68188493
100MP0003183_abnormal_peptide_metabolism0.67828041
101MP0001851_eye_inflammation0.67717954
102MP0003879_abnormal_hair_cell0.67226336
103MP0002697_abnormal_eye_size0.66805479
104MP0010307_abnormal_tumor_latency0.66627037
105MP0003984_embryonic_growth_retardation0.66587818
106MP0005621_abnormal_cell_physiology0.65210861
107MP0002092_abnormal_eye_morphology0.64441653
108MP0003453_abnormal_keratinocyte_physiol0.64366444
109MP0002796_impaired_skin_barrier0.64025277
110MP0002088_abnormal_embryonic_growth/wei0.62775909
111MP0002751_abnormal_autonomic_nervous0.62747814
112MP0005501_abnormal_skin_physiology0.60213620
113MP0002160_abnormal_reproductive_system0.59845770
114MP0004142_abnormal_muscle_tone0.59125918
115MP0003936_abnormal_reproductive_system0.58677060
116MP0002090_abnormal_vision0.58521509
117MP0003755_abnormal_palate_morphology0.58296277
118MP0000428_abnormal_craniofacial_morphol0.57720506
119MP0003938_abnormal_ear_development0.56850540
120MP0003252_abnormal_bile_duct0.55661055
121MP0005551_abnormal_eye_electrophysiolog0.55204197
122MP0003935_abnormal_craniofacial_develop0.55139282
123MP0005384_cellular_phenotype0.53856642
124MP0004264_abnormal_extraembryonic_tissu0.53139863
125MP0005197_abnormal_uvea_morphology0.52755157
126MP0010030_abnormal_orbit_morphology0.51742161
127MP0002332_abnormal_exercise_endurance0.51741075
128MP0004510_myositis0.51561952
129MP0002086_abnormal_extraembryonic_tissu0.50770926
130MP0000015_abnormal_ear_pigmentation0.50560167
131MP0000627_abnormal_mammary_gland0.50502944
132MP0006036_abnormal_mitochondrial_physio0.49323791
133MP0003567_abnormal_fetal_cardiomyocyte0.49261777
134MP0004381_abnormal_hair_follicle0.48344381
135MP0004145_abnormal_muscle_electrophysio0.48071261
136MP0000639_abnormal_adrenal_gland0.48054355
137MP0002127_abnormal_cardiovascular_syste0.46789279
138MP0008995_early_reproductive_senescence0.46765428
139MP0005391_vision/eye_phenotype0.46452622
140MP0000432_abnormal_head_morphology0.46003890
141MP0000678_abnormal_parathyroid_gland0.45990869
142MP0002938_white_spotting0.45254825
143MP0001986_abnormal_taste_sensitivity0.45192919
144MP0001286_abnormal_eye_development0.43163060

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.33939429
2Birth length less than 3rd percentile (HP:0003561)5.29947965
3Septo-optic dysplasia (HP:0100842)5.00468238
4Breast hypoplasia (HP:0003187)4.92802631
5Chromsome breakage (HP:0040012)4.90184559
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.72909748
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.39986204
8Abnormality of abdominal situs (HP:0011620)3.96656973
9Abdominal situs inversus (HP:0003363)3.96656973
10Patellar aplasia (HP:0006443)3.77573713
11Aplasia/Hypoplasia of the patella (HP:0006498)3.51298578
12Median cleft lip (HP:0000161)3.50671673
13Supernumerary spleens (HP:0009799)3.45888746
14Abnormal respiratory motile cilium physiology (HP:0012261)3.41474177
15Adrenal hypoplasia (HP:0000835)3.33589323
16Pancreatic fibrosis (HP:0100732)3.28252766
17Hypoplasia of the fovea (HP:0007750)3.27534988
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.27534988
19Short tibia (HP:0005736)3.24987517
20Oligodactyly (HP:0012165)3.21392089
21Abnormality of the labia minora (HP:0012880)3.20105096
22Meckel diverticulum (HP:0002245)3.08482975
23Abnormality of the preputium (HP:0100587)3.03572310
24Abnormality of the fovea (HP:0000493)3.00676435
25Pancreatic cysts (HP:0001737)2.95043590
26Absent radius (HP:0003974)2.94357549
27Abnormality of the ileum (HP:0001549)2.89919701
28Azoospermia (HP:0000027)2.89877076
29Rhinitis (HP:0012384)2.89477037
30Maternal diabetes (HP:0009800)2.88526054
31Abnormality of chromosome stability (HP:0003220)2.87058040
32Carpal bone hypoplasia (HP:0001498)2.86030529
33Premature ovarian failure (HP:0008209)2.84065009
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.81386447
35Papillary thyroid carcinoma (HP:0002895)2.80945384
36Absent forearm bone (HP:0003953)2.79220795
37Aplasia involving forearm bones (HP:0009822)2.79220795
38Stillbirth (HP:0003826)2.77026525
39Gonadotropin excess (HP:0000837)2.76577172
40Oral leukoplakia (HP:0002745)2.76016106
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.74626975
42Secondary amenorrhea (HP:0000869)2.73882355
43Osteomalacia (HP:0002749)2.72486493
44Chronic bronchitis (HP:0004469)2.71876302
45True hermaphroditism (HP:0010459)2.69611476
46Flat capital femoral epiphysis (HP:0003370)2.69449212
47Enlarged penis (HP:0000040)2.69133988
48Abnormal ciliary motility (HP:0012262)2.64110611
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.63072550
50Aplasia/Hypoplasia of the breasts (HP:0010311)2.62864888
51Wrist flexion contracture (HP:0001239)2.62859269
52Breast aplasia (HP:0100783)2.62743594
53Cerebral hypomyelination (HP:0006808)2.61653549
54Hypophosphatemic rickets (HP:0004912)2.60433341
55Duodenal stenosis (HP:0100867)2.56305353
56Small intestinal stenosis (HP:0012848)2.56305353
57Reticulocytopenia (HP:0001896)2.55626790
58Prostate neoplasm (HP:0100787)2.45335354
59Infertility (HP:0000789)2.44597649
60Parakeratosis (HP:0001036)2.43566463
61Sloping forehead (HP:0000340)2.40242008
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36485146
63Lip pit (HP:0100267)2.34829367
64Hypergonadotropic hypogonadism (HP:0000815)2.33036765
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32889258
66Volvulus (HP:0002580)2.32477470
67Cortical dysplasia (HP:0002539)2.32260682
68Type 2 muscle fiber atrophy (HP:0003554)2.32085996
69Abnormality of the phalanges of the hallux (HP:0010057)2.31219807
70Sensory axonal neuropathy (HP:0003390)2.29865305
71Abnormality of placental membranes (HP:0011409)2.27487907
72Amniotic constriction ring (HP:0009775)2.27487907
73Abnormal lung lobation (HP:0002101)2.26330458
74Abnormal gallbladder physiology (HP:0012438)2.25817832
75Cholecystitis (HP:0001082)2.25817832
76Optic nerve hypoplasia (HP:0000609)2.24318572
77Colon cancer (HP:0003003)2.24155505
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20837352
79Abnormality of alanine metabolism (HP:0010916)2.20837352
80Hyperalaninemia (HP:0003348)2.20837352
81Ankle contracture (HP:0006466)2.20793001
82Muscle fiber atrophy (HP:0100295)2.19536407
83Pulmonary fibrosis (HP:0002206)2.18204430
84Nephroblastoma (Wilms tumor) (HP:0002667)2.15666461
85Clubbing of toes (HP:0100760)2.15651459
86Capillary hemangiomas (HP:0005306)2.11565891
87Ectopic kidney (HP:0000086)2.11468912
88Increased nuchal translucency (HP:0010880)2.11089470
89Bone marrow hypocellularity (HP:0005528)2.10968649
90Fair hair (HP:0002286)2.10856302
91Shawl scrotum (HP:0000049)2.10220534
92Horseshoe kidney (HP:0000085)2.09558042
93Aplasia/Hypoplasia of the sternum (HP:0006714)2.07980225
94Impulsivity (HP:0100710)2.06603700
95Rhabdomyosarcoma (HP:0002859)2.04600052
96Megaloblastic anemia (HP:0001889)2.04414202
97Myelodysplasia (HP:0002863)2.04014517
98Duplicated collecting system (HP:0000081)2.02449706
99Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.02413749
100Short thumb (HP:0009778)2.01918602
101Abnormal spermatogenesis (HP:0008669)2.01152194
102Aplasia/Hypoplasia of the macula (HP:0008059)2.00761782
103Macrocytic anemia (HP:0001972)1.99569435
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99422310
105Embryonal renal neoplasm (HP:0011794)1.97571885
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96785909
107Facial hemangioma (HP:0000329)1.96088236
108Rough bone trabeculation (HP:0100670)1.96076264
109Microretrognathia (HP:0000308)1.95961524
110Abnormality of the carotid arteries (HP:0005344)1.95290082
111Abnormality of the renal collecting system (HP:0004742)1.95074423
112Occipital encephalocele (HP:0002085)1.94946336
113Aplastic anemia (HP:0001915)1.94056200
114Molar tooth sign on MRI (HP:0002419)1.93454980
115Abnormality of midbrain morphology (HP:0002418)1.93454980
116Cleft eyelid (HP:0000625)1.92946557
117Abnormality of the duodenum (HP:0002246)1.91781434
118Anterior segment dysgenesis (HP:0007700)1.90692385
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89695466
120Abnormal respiratory epithelium morphology (HP:0012253)1.89586659
121Abnormal respiratory motile cilium morphology (HP:0005938)1.89586659
122Bronchiectasis (HP:0002110)1.89111086
123Hypokinesia (HP:0002375)1.89042678
124Abnormality of the septum pellucidum (HP:0007375)1.88431907
125Triphalangeal thumb (HP:0001199)1.88029131
126Bile duct proliferation (HP:0001408)1.87906387
127Abnormal biliary tract physiology (HP:0012439)1.87906387
128Bifid tongue (HP:0010297)1.87265610
129Limb hypertonia (HP:0002509)1.86913319
130Abnormality of lateral ventricle (HP:0030047)1.85654099
131Fibular aplasia (HP:0002990)1.85522287
132Bicornuate uterus (HP:0000813)1.84821394
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.84709088
134Tracheoesophageal fistula (HP:0002575)1.84452178
135Exertional dyspnea (HP:0002875)1.83527404
136Sparse eyelashes (HP:0000653)1.83509484
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82497079
138Generalized aminoaciduria (HP:0002909)1.82466761
139Premature graying of hair (HP:0002216)1.81687836
140Absent septum pellucidum (HP:0001331)1.81178303
141Abnormality of chromosome segregation (HP:0002916)1.79863468
142Male pseudohermaphroditism (HP:0000037)1.79522173
143Oligodactyly (hands) (HP:0001180)1.77972375
144Urethral obstruction (HP:0000796)1.77015016
145Acute myeloid leukemia (HP:0004808)1.74418292
146Posterior subcapsular cataract (HP:0007787)1.73142231
147Absent hand (HP:0004050)1.73103931
148Absent thumb (HP:0009777)1.72960568
149Cafe-au-lait spot (HP:0000957)1.72520412
150Acute necrotizing encephalopathy (HP:0006965)1.72079314
151Renal Fanconi syndrome (HP:0001994)1.71796385
152Increased hepatocellular lipid droplets (HP:0006565)1.70558521
153Combined immunodeficiency (HP:0005387)1.70287232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.34453515
2PLK43.87751750
3LATS13.84536133
4STK38L3.72864050
5BMPR23.57551424
6MOS3.48731580
7MAP3K63.44689112
8LATS23.37787254
9TTK3.20161884
10CDC72.97594805
11VRK22.44857141
12MUSK2.34261390
13WEE12.34154012
14TAOK32.10655646
15EIF2AK12.08965013
16CDK82.05585553
17PLK11.98945876
18BRAF1.98058775
19ERBB41.85481574
20SRPK11.84565528
21NEK21.83118213
22ARAF1.78393749
23PBK1.64468437
24CHEK21.64361883
25STK101.62988210
26MET1.60584537
27VRK11.57810309
28DYRK21.57756438
29BRSK21.55293515
30STK31.47711667
31TRIM281.40161577
32PRKCI1.36625996
33AURKB1.34197387
34NEK11.23161262
35PLK31.22462422
36TNIK1.21545655
37AURKA1.20987684
38ACVR1B1.19711907
39MELK1.18304113
40MAP3K81.15129280
41RAF11.07523627
42PINK11.04889357
43BRSK10.98245199
44MAP3K130.96078125
45KSR20.94940624
46KSR10.94689505
47ABL20.89914524
48CDK70.88729982
49NLK0.87066492
50CDK90.81823293
51MAP3K90.80894574
52BMPR1B0.80012450
53STK240.71259875
54NUAK10.71018348
55TSSK60.70376106
56CHEK10.69383265
57MKNK20.68715317
58EIF2AK20.61998572
59ATR0.61803386
60TIE10.61663701
61MAPKAPK30.60624197
62STK390.59380017
63TLK10.57735237
64CDK40.57576101
65CCNB10.56978468
66CDK30.56461583
67STK40.56329188
68DMPK0.56049160
69ATM0.55940100
70NEK60.54785405
71STK160.53655202
72STK380.53121617
73EIF2AK30.52181746
74CSNK1G10.52127754
75ZAK0.51908272
76TESK20.50878245
77NTRK20.50711891
78MKNK10.49998348
79LRRK20.47101227
80MAP2K70.45135020
81MAPK130.44685349
82RPS6KB20.43865256
83WNK30.39528638
84OBSCN0.39323716
85EPHA20.38757896
86DYRK30.38297446
87TAF10.37773797
88TGFBR10.37535163
89PAK10.37257150
90CSNK2A20.36727130
91NME20.36555443
92CSNK2A10.35823523
93CSNK1G30.34018198
94* CDK10.33957628
95CSNK1E0.33720544
96MAPKAPK50.33045666
97RPS6KA40.32673675
98PRKAA10.31711270
99NEK90.29841542
100* CDK20.29378457
101CLK10.29345945
102PNCK0.29281259
103IRAK30.29230249
104PKN10.27882421
105PRKD30.27741039
106PIM10.27619655
107CDK150.26868795
108CDK11A0.26461677
109PRKG10.26295762
110CDK180.25712226
111CSNK1D0.25564242
112MAP3K50.24580799
113NME10.23969272
114CDK140.22302207
115MARK30.22137096
116CSNK1A1L0.21894645
117TYK20.21479416
118PRKACB0.21038852
119MST40.20182085
120TRPM70.20170246
121SGK20.18685720
122MAP3K40.18652282
123OXSR10.18274230
124CAMK2A0.18274221
125PLK20.18193572
126CDK190.17689985
127ABL10.17419412
128AKT20.17259121
129PRKAA20.16915012
130PDK20.14618478
131CSNK1G20.13835007
132CHUK0.13667311

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.13638287
2Basal transcription factors_Homo sapiens_hsa030223.84300137
3Homologous recombination_Homo sapiens_hsa034403.51768481
4DNA replication_Homo sapiens_hsa030303.40097380
5* Cell cycle_Homo sapiens_hsa041103.39909711
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31224266
7RNA degradation_Homo sapiens_hsa030183.21597125
8Mismatch repair_Homo sapiens_hsa034303.03421932
9Proteasome_Homo sapiens_hsa030503.01714936
10Fanconi anemia pathway_Homo sapiens_hsa034603.00354897
11RNA transport_Homo sapiens_hsa030132.90300101
12Nucleotide excision repair_Homo sapiens_hsa034202.66675779
13Base excision repair_Homo sapiens_hsa034102.63862601
14Vitamin B6 metabolism_Homo sapiens_hsa007502.58871962
15Pyrimidine metabolism_Homo sapiens_hsa002402.36557921
16Spliceosome_Homo sapiens_hsa030402.14904783
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.14553729
18Non-homologous end-joining_Homo sapiens_hsa034501.97456008
19p53 signaling pathway_Homo sapiens_hsa041151.91823964
20Caffeine metabolism_Homo sapiens_hsa002321.75562661
21Ovarian steroidogenesis_Homo sapiens_hsa049131.66123235
22Ribosome_Homo sapiens_hsa030101.56420935
23Purine metabolism_Homo sapiens_hsa002301.51107780
24* Oocyte meiosis_Homo sapiens_hsa041141.50123834
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49206182
26Huntingtons disease_Homo sapiens_hsa050161.46177312
27Circadian rhythm_Homo sapiens_hsa047101.46016312
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45005052
29mRNA surveillance pathway_Homo sapiens_hsa030151.37882783
30Linoleic acid metabolism_Homo sapiens_hsa005911.34258867
31Ether lipid metabolism_Homo sapiens_hsa005651.18282356
32Folate biosynthesis_Homo sapiens_hsa007901.18107059
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15848411
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.10191345
35One carbon pool by folate_Homo sapiens_hsa006701.08468078
36Epstein-Barr virus infection_Homo sapiens_hsa051691.07961196
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03548401
38Fatty acid elongation_Homo sapiens_hsa000621.03050700
39Pyruvate metabolism_Homo sapiens_hsa006201.02426316
40TGF-beta signaling pathway_Homo sapiens_hsa043500.98079214
41Olfactory transduction_Homo sapiens_hsa047400.97155353
42Propanoate metabolism_Homo sapiens_hsa006400.95464692
43Arachidonic acid metabolism_Homo sapiens_hsa005900.93613311
44Herpes simplex infection_Homo sapiens_hsa051680.91861884
45Oxidative phosphorylation_Homo sapiens_hsa001900.88729311
46Cardiac muscle contraction_Homo sapiens_hsa042600.78239388
47Regulation of autophagy_Homo sapiens_hsa041400.77139727
48Glutathione metabolism_Homo sapiens_hsa004800.76455775
49Protein export_Homo sapiens_hsa030600.76014594
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75647130
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72092902
52Parkinsons disease_Homo sapiens_hsa050120.69188726
53Graft-versus-host disease_Homo sapiens_hsa053320.66052638
54Steroid biosynthesis_Homo sapiens_hsa001000.66012636
55Sphingolipid metabolism_Homo sapiens_hsa006000.62990633
56MicroRNAs in cancer_Homo sapiens_hsa052060.62385913
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59639798
58Pentose phosphate pathway_Homo sapiens_hsa000300.59606188
59Pancreatic cancer_Homo sapiens_hsa052120.57948786
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56219889
61Vitamin digestion and absorption_Homo sapiens_hsa049770.55298014
62Phototransduction_Homo sapiens_hsa047440.54682790
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53838545
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51296614
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.50252021
66* HTLV-I infection_Homo sapiens_hsa051660.48094791
67Hippo signaling pathway_Homo sapiens_hsa043900.47575327
68Influenza A_Homo sapiens_hsa051640.46818281
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45359567
70Allograft rejection_Homo sapiens_hsa053300.45193944
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42997508
72Arginine and proline metabolism_Homo sapiens_hsa003300.42120725
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.40234173
74Gap junction_Homo sapiens_hsa045400.39966266
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.39379407
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38346430
77Metabolic pathways_Homo sapiens_hsa011000.36153350
78Viral carcinogenesis_Homo sapiens_hsa052030.36078699
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35370544
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34561705
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34502774
82Rheumatoid arthritis_Homo sapiens_hsa053230.34414265
83Notch signaling pathway_Homo sapiens_hsa043300.34207292
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33456038
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.33253505
86Colorectal cancer_Homo sapiens_hsa052100.32198179
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31076330
88FoxO signaling pathway_Homo sapiens_hsa040680.30257991
89Malaria_Homo sapiens_hsa051440.28599348
90Measles_Homo sapiens_hsa051620.28417464
91Thyroid cancer_Homo sapiens_hsa052160.27979125
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27912637
93Asthma_Homo sapiens_hsa053100.27908310
94Alcoholism_Homo sapiens_hsa050340.26066041
95Shigellosis_Homo sapiens_hsa051310.25954887
96Hematopoietic cell lineage_Homo sapiens_hsa046400.25925238
97Primary immunodeficiency_Homo sapiens_hsa053400.25114023
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24959601
99Alzheimers disease_Homo sapiens_hsa050100.23872576
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23775666
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23669952
102Biosynthesis of amino acids_Homo sapiens_hsa012300.22433750
103Dorso-ventral axis formation_Homo sapiens_hsa043200.21607014
104Hepatitis B_Homo sapiens_hsa051610.21552802
105Small cell lung cancer_Homo sapiens_hsa052220.21509737
106Nicotine addiction_Homo sapiens_hsa050330.20734910
107Selenocompound metabolism_Homo sapiens_hsa004500.20659676
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20319979
109Autoimmune thyroid disease_Homo sapiens_hsa053200.20269146
110Carbon metabolism_Homo sapiens_hsa012000.20034674
111Apoptosis_Homo sapiens_hsa042100.19923360
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19351569
113Basal cell carcinoma_Homo sapiens_hsa052170.19215379
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16534747
115Hedgehog signaling pathway_Homo sapiens_hsa043400.16339411
116Prolactin signaling pathway_Homo sapiens_hsa049170.15005121
117Adherens junction_Homo sapiens_hsa045200.14044123
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.13666792
119Sulfur relay system_Homo sapiens_hsa041220.11532837
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11496929
121Antigen processing and presentation_Homo sapiens_hsa046120.11007114
122Systemic lupus erythematosus_Homo sapiens_hsa053220.09967947
123Pathways in cancer_Homo sapiens_hsa052000.09205099
124Wnt signaling pathway_Homo sapiens_hsa043100.07453330
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.07346376
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06949834
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.03849228
128Synaptic vesicle cycle_Homo sapiens_hsa047210.02869131
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.01011232
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00430245
131N-Glycan biosynthesis_Homo sapiens_hsa005100.00174247
132Taste transduction_Homo sapiens_hsa04742-0.0144551

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