PTTG1IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.80436607
2Golgi transport vesicle coating (GO:0048200)5.80436607
3protein retention in ER lumen (GO:0006621)5.19106516
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.11471437
5cysteine metabolic process (GO:0006534)4.62106034
6sulfur amino acid catabolic process (GO:0000098)4.61042825
7serine family amino acid catabolic process (GO:0009071)4.53741729
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.47177310
9L-phenylalanine catabolic process (GO:0006559)4.47177310
10L-phenylalanine metabolic process (GO:0006558)4.43913210
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.43913210
12vitamin transmembrane transport (GO:0035461)4.12934618
13cell adhesion mediated by integrin (GO:0033627)4.11726731
14homocysteine metabolic process (GO:0050667)4.09532514
15barbed-end actin filament capping (GO:0051016)4.09363357
16skin morphogenesis (GO:0043589)4.07255861
17aromatic amino acid family catabolic process (GO:0009074)4.05893757
18basement membrane organization (GO:0071711)4.03586046
19alpha-linolenic acid metabolic process (GO:0036109)4.01781367
20urate metabolic process (GO:0046415)3.97796337
21amino-acid betaine metabolic process (GO:0006577)3.95451589
22glyoxylate metabolic process (GO:0046487)3.93906555
23protein localization to endosome (GO:0036010)3.92980672
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.91906049
25peptidyl-glutamic acid carboxylation (GO:0017187)3.90931087
26protein carboxylation (GO:0018214)3.90931087
27protein maturation by protein folding (GO:0022417)3.88427723
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.86896162
29glycine metabolic process (GO:0006544)3.85474047
30biotin metabolic process (GO:0006768)3.77827188
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.76150118
32pantothenate metabolic process (GO:0015939)3.76101079
33serine family amino acid metabolic process (GO:0009069)3.75487843
34tryptophan catabolic process (GO:0006569)3.73346683
35indole-containing compound catabolic process (GO:0042436)3.73346683
36indolalkylamine catabolic process (GO:0046218)3.73346683
37pinocytosis (GO:0006907)3.72922331
38negative regulation of fibrinolysis (GO:0051918)3.70816950
39regulation of protein activation cascade (GO:2000257)3.68440494
40lysine metabolic process (GO:0006553)3.63799586
41lysine catabolic process (GO:0006554)3.63799586
42peptidyl-proline hydroxylation (GO:0019511)3.63153318
43tryptophan metabolic process (GO:0006568)3.62769400
44kynurenine metabolic process (GO:0070189)3.62212688
45regulation of complement activation (GO:0030449)3.59022239
46bile acid biosynthetic process (GO:0006699)3.54729525
47regulation of cholesterol homeostasis (GO:2000188)3.49451756
48serine family amino acid biosynthetic process (GO:0009070)3.48552455
49complement activation, alternative pathway (GO:0006957)3.44073111
50valine metabolic process (GO:0006573)3.40835481
51actin filament depolymerization (GO:0030042)3.37975453
52protein hydroxylation (GO:0018126)3.36181381
53epithelial cell-cell adhesion (GO:0090136)3.33378928
54folic acid transport (GO:0015884)3.33173457
55hemidesmosome assembly (GO:0031581)3.32478993
56extracellular fibril organization (GO:0043206)3.31062467
57regulation of extracellular matrix disassembly (GO:0010715)3.27264994
58high-density lipoprotein particle remodeling (GO:0034375)3.26892098
59apoptotic cell clearance (GO:0043277)3.26093482
60cellular glucuronidation (GO:0052695)3.25503147
61regulation of fibrinolysis (GO:0051917)3.25045809
62plasma lipoprotein particle clearance (GO:0034381)3.23086543
63urea cycle (GO:0000050)3.22899948
64urea metabolic process (GO:0019627)3.22899948
65reverse cholesterol transport (GO:0043691)3.20804572
66aromatic amino acid family metabolic process (GO:0009072)3.20324381
67fatty acid beta-oxidation (GO:0006635)3.17369265
68positive regulation of triglyceride lipase activity (GO:0061365)3.16960733
69positive regulation of lipoprotein lipase activity (GO:0051006)3.16960733
70folic acid metabolic process (GO:0046655)3.15144653
71bile acid metabolic process (GO:0008206)3.14977988
72vitamin transport (GO:0051180)3.14977504
73regulation of triglyceride catabolic process (GO:0010896)3.14795653
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12139552
752-oxoglutarate metabolic process (GO:0006103)3.10257366
76triglyceride homeostasis (GO:0070328)3.10101632
77acylglycerol homeostasis (GO:0055090)3.10101632
78UDP-N-acetylglucosamine metabolic process (GO:0006047)3.10021811
79drug transmembrane transport (GO:0006855)3.09660301
80fatty acid oxidation (GO:0019395)3.08765226
81uronic acid metabolic process (GO:0006063)3.06924599
82glucuronate metabolic process (GO:0019585)3.06924599
83adhesion of symbiont to host (GO:0044406)3.06584115
84alpha-amino acid catabolic process (GO:1901606)3.06254474
85lipid oxidation (GO:0034440)3.05951737
86bile acid and bile salt transport (GO:0015721)3.05396401
87carnitine metabolic process (GO:0009437)3.04204596
88stress fiber assembly (GO:0043149)3.03941409
89modified amino acid transport (GO:0072337)3.03126482
90cell-substrate junction assembly (GO:0007044)3.02865507
91regulation of cholesterol esterification (GO:0010872)3.02113752
92fibrinolysis (GO:0042730)3.01192141
93membrane protein ectodomain proteolysis (GO:0006509)3.00974523
94cellular amino acid catabolic process (GO:0009063)2.98403403
95positive regulation of receptor recycling (GO:0001921)2.98270113
96low-density lipoprotein particle clearance (GO:0034383)2.96020503
97S-adenosylmethionine metabolic process (GO:0046500)2.95281945
98fibril organization (GO:0097435)2.94715328
99endodermal cell differentiation (GO:0035987)2.94272434
100regulation of cholesterol metabolic process (GO:0090181)2.93979529
101nitrogen cycle metabolic process (GO:0071941)2.93165878
102proline biosynthetic process (GO:0006561)2.92437315
103desmosome organization (GO:0002934)2.92428531
104protein-lipid complex remodeling (GO:0034368)2.91362294
105macromolecular complex remodeling (GO:0034367)2.91362294
106plasma lipoprotein particle remodeling (GO:0034369)2.91362294
107regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91012890
108dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90102768
109fatty acid catabolic process (GO:0009062)2.88928702
110regulation of early endosome to late endosome transport (GO:2000641)2.87117486
111sulfur amino acid metabolic process (GO:0000096)2.86827678
1124-hydroxyproline metabolic process (GO:0019471)2.85611805
113drug transport (GO:0015893)2.85110793
114semaphorin-plexin signaling pathway (GO:0071526)2.84988397
115response to mercury ion (GO:0046689)2.84830830
116negative regulation of cholesterol transport (GO:0032375)2.84813735
117negative regulation of sterol transport (GO:0032372)2.84813735
118L-serine metabolic process (GO:0006563)2.83788222
119positive regulation of triglyceride metabolic process (GO:0090208)2.82825334
120lipoprotein metabolic process (GO:0042157)2.82728166
121vesicle coating (GO:0006901)2.82232721
122substrate-dependent cell migration (GO:0006929)2.81287487
123organic acid catabolic process (GO:0016054)2.81272386
124carboxylic acid catabolic process (GO:0046395)2.81272386
125ethanol oxidation (GO:0006069)2.80839549
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79858497
127branched-chain amino acid catabolic process (GO:0009083)2.79834129
128positive regulation of extracellular matrix organization (GO:1903055)2.79257232
129cellular copper ion homeostasis (GO:0006878)2.78554361
130amyloid precursor protein catabolic process (GO:0042987)2.77970855
131fructose metabolic process (GO:0006000)2.77478321
132cellular ketone body metabolic process (GO:0046950)2.77106054
133regulation of plasminogen activation (GO:0010755)2.76269034
134cholesterol homeostasis (GO:0042632)2.75912569
135platelet degranulation (GO:0002576)2.75086792
136sterol homeostasis (GO:0055092)2.74508469
137cellular modified amino acid catabolic process (GO:0042219)2.74358429
138regulation of cholesterol biosynthetic process (GO:0045540)2.73818037
139monocarboxylic acid catabolic process (GO:0072329)2.73736250
140positive regulation of fatty acid beta-oxidation (GO:0032000)2.73304966
141type B pancreatic cell proliferation (GO:0044342)2.73259248
142cofactor transport (GO:0051181)2.72677192
143muscle cell migration (GO:0014812)2.72101197
144activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.71321455
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.70099601
146hypotonic response (GO:0006971)2.69483911
147adherens junction assembly (GO:0034333)2.67127495
148adhesion of symbiont to host cell (GO:0044650)2.65040521
149virion attachment to host cell (GO:0019062)2.65040521
150endocardial cushion development (GO:0003197)2.64080916
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63903983
152positive regulation of osteoblast proliferation (GO:0033690)2.62788043
153hyaluronan catabolic process (GO:0030214)2.62076116
154vascular endothelial growth factor signaling pathway (GO:0038084)2.61060977
155negative regulation of chondrocyte differentiation (GO:0032331)2.60828520
156regulation of extracellular matrix organization (GO:1903053)2.60106492
157positive regulation of nuclease activity (GO:0032075)2.57026418
158regulation of apoptotic cell clearance (GO:2000425)2.56977531
159chondrocyte proliferation (GO:0035988)2.56951780
160regulation of integrin-mediated signaling pathway (GO:2001044)2.54496577
161endothelial cell morphogenesis (GO:0001886)2.51701678
162positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50016945
163negative regulation of fatty acid transport (GO:2000192)2.49816046
164vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49587872
165cell-substrate adherens junction assembly (GO:0007045)2.49025330
166focal adhesion assembly (GO:0048041)2.49025330
167regulation of metalloenzyme activity (GO:0048552)2.48894712
168melanin biosynthetic process (GO:0042438)2.48855707
169mesodermal cell differentiation (GO:0048333)2.48349474
170regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45479828
171very-low-density lipoprotein particle assembly (GO:0034379)2.44660395
172endoplasmic reticulum unfolded protein response (GO:0030968)2.44402448
173embryo implantation (GO:0007566)2.43781742
174wound healing, spreading of cells (GO:0044319)2.42335826
175wound healing, spreading of epidermal cells (GO:0035313)2.42152459
176cell-cell junction maintenance (GO:0045217)2.39816293
177negative regulation of protein localization to plasma membrane (GO:1903077)2.39381624
178negative regulation of anoikis (GO:2000811)2.38819513
179negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38410617
180positive regulation of endothelial cell apoptotic process (GO:2000353)2.38308924
181positive regulation of pseudopodium assembly (GO:0031274)2.37934109
182COPII vesicle coating (GO:0048208)2.37036653
183glucose 6-phosphate metabolic process (GO:0051156)2.36892295
184positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.35374918
185pentose-phosphate shunt (GO:0006098)2.34848083
186cortical actin cytoskeleton organization (GO:0030866)2.32095054
187membrane raft organization (GO:0031579)2.31539104
188extracellular matrix disassembly (GO:0022617)2.31050854
189collagen fibril organization (GO:0030199)2.30432836
190glucose catabolic process (GO:0006007)2.30033321
191endothelial cell chemotaxis (GO:0035767)2.29609111
192ER-nucleus signaling pathway (GO:0006984)2.28242805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.94270601
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.12188748
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75766736
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.62735147
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.96116558
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.44931472
7CLOCK_20551151_ChIP-Seq_293T_Human3.18826908
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18024235
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98802277
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.91943097
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.81292642
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62798490
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.61906219
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33350194
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17618386
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16728097
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.01161133
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.94068069
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91109658
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90693310
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.86401764
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85947379
23ZNF263_19887448_ChIP-Seq_K562_Human1.79084703
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75505990
25GATA1_22025678_ChIP-Seq_K562_Human1.71858780
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69079487
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61156410
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60645824
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59840068
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59310629
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56945690
32AR_21909140_ChIP-Seq_LNCAP_Human1.56444113
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56376136
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53609375
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.53270547
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.51264945
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49529958
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47854251
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47595071
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47049994
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43796635
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43399125
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38961255
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38789495
45TP53_22127205_ChIP-Seq_IMR90_Human1.36001511
46* KDM2B_26808549_Chip-Seq_K562_Human1.33522314
47* GATA4_25053715_ChIP-Seq_YYC3_Human1.33416682
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31693568
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30186874
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29354662
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27751355
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26999972
53* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25716300
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25421909
55* TBX20_22328084_ChIP-Seq_HEART_Mouse1.23097400
56* TBX20_22080862_ChIP-Seq_HEART_Mouse1.23097400
57ATF3_27146783_Chip-Seq_COLON_Human1.21502282
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20220505
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.19526881
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16214510
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15813633
62* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15486851
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12391508
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.11466221
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11202113
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10409916
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09569867
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09025694
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08083934
70VDR_21846776_ChIP-Seq_THP-1_Human1.07923103
71* RACK7_27058665_Chip-Seq_MCF-7_Human1.07344739
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.07091893
73SOX2_20726797_ChIP-Seq_SW620_Human1.05906912
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.05835448
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05641451
76TCF7_22412390_ChIP-Seq_EML_Mouse1.05586091
77* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05042144
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04963861
79SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04861190
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04460692
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04187025
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03281037
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03128550
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02554523
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02436836
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02148039
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01681107
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01296185
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99712584
90RUNX1_27514584_Chip-Seq_MCF-7_Human0.99683334
91* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99241422
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97853077
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97431706
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97397461
95EGR1_19374776_ChIP-ChIP_THP-1_Human0.95547543
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95360485
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95017088
98MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94960858
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94542659
100WT1_19549856_ChIP-ChIP_CCG9911_Human0.94468243
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93075051
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92983005
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92520395
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91199310
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.91081087
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91060740
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90099161
108* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89561515
109PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88681058
110* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88094721
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87610872
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86244107
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86244107
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.85427413
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85118507
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85044532
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84456331
118FOXA2_19822575_ChIP-Seq_HepG2_Human0.83691555
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.83240486
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82745233
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81785402
122* GATA3_24758297_ChIP-Seq_MCF-7_Human0.81287859
123BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79807384
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78712104
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.76135252
126* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76089592
127* UBF1/2_26484160_Chip-Seq_HMECs_Human0.74946375
128KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74796617
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74697864
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73794080
131SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.71173215
132BCOR_27268052_Chip-Seq_Bcells_Human0.70517138
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70189940
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70141250
135* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69720242
136* NCOR1_26117541_ChIP-Seq_K562_Human0.69714932
137IRF8_27001747_Chip-Seq_BMDM_Mouse0.69346688
138LXR_22292898_ChIP-Seq_THP-1_Human0.68890668
139* CJUN_26792858_Chip-Seq_BT549_Human0.68624378
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68572578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.86644453
2MP0005360_urolithiasis4.51387079
3MP0005365_abnormal_bile_salt3.81729461
4MP0009840_abnormal_foam_cell3.62998004
5MP0005257_abnormal_intraocular_pressure3.62624038
6MP0005085_abnormal_gallbladder_physiolo3.55855498
7MP0008875_abnormal_xenobiotic_pharmacok2.93969377
8MP0003806_abnormal_nucleotide_metabolis2.60694744
9MP0003252_abnormal_bile_duct2.58076907
10MP0010329_abnormal_lipoprotein_level2.43832424
11MP0008438_abnormal_cutaneous_collagen2.43585083
12MP0005332_abnormal_amino_acid2.37480428
13MP0003191_abnormal_cellular_cholesterol2.32934787
14MP0005171_absent_coat_pigmentation2.30246104
15MP0003705_abnormal_hypodermis_morpholog2.29185353
16MP0004858_abnormal_nervous_system2.20376036
17MP0002138_abnormal_hepatobiliary_system2.09019834
18MP0005409_darkened_coat_color2.06902716
19MP0004019_abnormal_vitamin_homeostasis2.06453911
20MP0003195_calcinosis2.05179854
21MP0003091_abnormal_cell_migration1.96650645
22MP0001666_abnormal_nutrient_absorption1.86610554
23MP0010368_abnormal_lymphatic_system1.77678571
24MP0005623_abnormal_meninges_morphology1.73269951
25MP0001849_ear_inflammation1.72999367
26MP0000609_abnormal_liver_physiology1.71923066
27MP0009643_abnormal_urine_homeostasis1.70947729
28MP0005058_abnormal_lysosome_morphology1.69752328
29MP0003329_amyloid_beta_deposits1.67222227
30MP0000751_myopathy1.66826125
31MP0003186_abnormal_redox_activity1.66427367
32MP0005083_abnormal_biliary_tract1.65896920
33MP0005319_abnormal_enzyme/_coenzyme1.63145294
34MP0003724_increased_susceptibility_to1.62594475
35MP0003950_abnormal_plasma_membrane1.56838202
36MP0002896_abnormal_bone_mineralization1.54164116
37MP0002118_abnormal_lipid_homeostasis1.52481725
38MP0010030_abnormal_orbit_morphology1.51203326
39MP0001958_emphysema1.45550212
40MP0004272_abnormal_basement_membrane1.44724274
41MP0001915_intracranial_hemorrhage1.43493779
42MP0009780_abnormal_chondrocyte_physiolo1.41185740
43MP0001756_abnormal_urination1.37320435
44MP0000537_abnormal_urethra_morphology1.37138248
45MP0010234_abnormal_vibrissa_follicle1.35416953
46MP0005275_abnormal_skin_tensile1.33285969
47MP0004233_abnormal_muscle_weight1.30352554
48MP0003279_aneurysm1.29685538
49MP0009384_cardiac_valve_regurgitation1.29209460
50MP0000534_abnormal_ureter_morphology1.26885534
51MP0000858_altered_metastatic_potential1.23574230
52MP0005197_abnormal_uvea_morphology1.23141899
53MP0006054_spinal_hemorrhage1.23027718
54MP0001542_abnormal_bone_strength1.20170241
55MP0005670_abnormal_white_adipose1.19331757
56MP0005377_hearing/vestibular/ear_phenot1.19132416
57MP0003878_abnormal_ear_physiology1.19132416
58MP0001661_extended_life_span1.18931023
59MP0003656_abnormal_erythrocyte_physiolo1.15872036
60MP0003172_abnormal_lysosome_physiology1.12673078
61MP0000598_abnormal_liver_morphology1.12187757
62MP0003718_maternal_effect1.11841810
63MP0002089_abnormal_postnatal_growth/wei1.10916797
64MP0005451_abnormal_body_composition1.10857082
65MP0003566_abnormal_cell_adhesion1.10182628
66MP0001764_abnormal_homeostasis1.07471137
67MP0003123_paternal_imprinting1.06812751
68MP0005503_abnormal_tendon_morphology1.05146399
69MP0005167_abnormal_blood-brain_barrier1.03074264
70MP0000762_abnormal_tongue_morphology1.02601753
71MP0002136_abnormal_kidney_physiology1.02500648
72MP0000003_abnormal_adipose_tissue1.00761285
73MP0005023_abnormal_wound_healing0.99688049
74MP0005636_abnormal_mineral_homeostasis0.98216380
75MP0009053_abnormal_anal_canal0.96696608
76MP0008004_abnormal_stomach_pH0.94844875
77MP0005395_other_phenotype0.94172425
78MP0005076_abnormal_cell_differentiation0.94142571
79MP0005584_abnormal_enzyme/coenzyme_acti0.94135255
80MP0008469_abnormal_protein_level0.93806316
81MP0003183_abnormal_peptide_metabolism0.93112446
82MP0005084_abnormal_gallbladder_morpholo0.93026363
83MP0003385_abnormal_body_wall0.92803552
84MP0003300_gastrointestinal_ulcer0.92717679
85MP0005220_abnormal_exocrine_pancreas0.92281324
86MP0002060_abnormal_skin_morphology0.91157193
87MP0003075_altered_response_to0.89733431
88MP0001879_abnormal_lymphatic_vessel0.89329253
89MP0003941_abnormal_skin_development0.89324039
90MP0009764_decreased_sensitivity_to0.89271001
91MP0002998_abnormal_bone_remodeling0.88177299
92MP0005501_abnormal_skin_physiology0.87169439
93MP0005666_abnormal_adipose_tissue0.87124651
94MP0003634_abnormal_glial_cell0.85269964
95MP0001533_abnormal_skeleton_physiology0.84476094
96MP0000343_altered_response_to0.84278909
97MP0000733_abnormal_muscle_development0.82812825
98MP0005330_cardiomyopathy0.82449782
99MP0001614_abnormal_blood_vessel0.81638109
100MP0005193_abnormal_anterior_eye0.81524832
101MP0008260_abnormal_autophagy0.81254214
102MP0003868_abnormal_feces_composition0.80552382
103MP0002254_reproductive_system_inflammat0.80052976
104MP0000467_abnormal_esophagus_morphology0.79099250
105MP0003942_abnormal_urinary_system0.78830889
106MP0002295_abnormal_pulmonary_circulatio0.78688768
107MP0003115_abnormal_respiratory_system0.76663925
108MP0005621_abnormal_cell_physiology0.75996185
109MP0005397_hematopoietic_system_phenotyp0.75963387
110MP0001545_abnormal_hematopoietic_system0.75963387
111MP0002796_impaired_skin_barrier0.75768358
112MP0005595_abnormal_vascular_smooth0.74887624
113MP0000767_abnormal_smooth_muscle0.74239987
114MP0004782_abnormal_surfactant_physiolog0.73814112
115MP0004130_abnormal_muscle_cell0.72655683
116MP0001299_abnormal_eye_distance/0.72559548
117MP0002092_abnormal_eye_morphology0.72177800
118MP0000013_abnormal_adipose_tissue0.71997977
119MP0004264_abnormal_extraembryonic_tissu0.71771789
120MP0001853_heart_inflammation0.71739035
121MP0005164_abnormal_response_to0.71398863
122MP0000249_abnormal_blood_vessel0.71337363
123MP0009763_increased_sensitivity_to0.70672174
124MP0002128_abnormal_blood_circulation0.70605501
125MP0003828_pulmonary_edema0.70570420
126MP0000462_abnormal_digestive_system0.69981752
127MP0003011_delayed_dark_adaptation0.69113767
128MP0003436_decreased_susceptibility_to0.69013671
129MP0002168_other_aberrant_phenotype0.68996663
130MP0006082_CNS_inflammation0.68671617
131MP0009642_abnormal_blood_homeostasis0.68413158
132MP0003315_abnormal_perineum_morphology0.67835135
133MP0010630_abnormal_cardiac_muscle0.67313157
134MP0000747_muscle_weakness0.66563210
135MP0010352_gastrointestinal_tract_polyps0.65799228
136MP0005508_abnormal_skeleton_morphology0.65628846
137MP0002135_abnormal_kidney_morphology0.64506580
138MP0000371_diluted_coat_color0.64471742
139MP0002113_abnormal_skeleton_development0.63973215
140MP0000604_amyloidosis0.63811731
141MP0000750_abnormal_muscle_regeneration0.63795775
142MP0006138_congestive_heart_failure0.63689148
143MP0003453_abnormal_keratinocyte_physiol0.62777759
144MP0005390_skeleton_phenotype0.62356785
145MP0004947_skin_inflammation0.62054583
146MP0000681_abnormal_thyroid_gland0.61723176
147MP0000163_abnormal_cartilage_morphology0.61696139
148MP0001243_abnormal_dermal_layer0.61094089
149MP0005408_hypopigmentation0.61048560
150MP0005464_abnormal_platelet_physiology0.60220306
151MP0005165_increased_susceptibility_to0.59817057
152MP0009278_abnormal_bone_marrow0.59649166
153MP0002971_abnormal_brown_adipose0.59365513
154MP0005647_abnormal_sex_gland0.58641854
155MP0002877_abnormal_melanocyte_morpholog0.57158077
156MP0009115_abnormal_fat_cell0.56740948

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.74010716
2Hyperglycinemia (HP:0002154)4.46392650
3Xanthomatosis (HP:0000991)4.39289041
4Deep venous thrombosis (HP:0002625)4.34168957
5Gout (HP:0001997)4.28419025
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.16998189
7Abnormality of serine family amino acid metabolism (HP:0010894)4.14867786
8Abnormality of glycine metabolism (HP:0010895)4.14867786
9Intrahepatic cholestasis (HP:0001406)3.83945004
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79911421
11Premature rupture of membranes (HP:0001788)3.55074625
12Hyperlipoproteinemia (HP:0010980)3.46580248
13Arterial tortuosity (HP:0005116)3.34708287
14Abnormality of fatty-acid metabolism (HP:0004359)3.33061803
15Hypobetalipoproteinemia (HP:0003563)3.29927783
16Vascular tortuosity (HP:0004948)3.28322547
17Hyperammonemia (HP:0001987)3.27389755
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23281998
19Prolonged partial thromboplastin time (HP:0003645)3.20951811
20Complement deficiency (HP:0004431)3.15956460
21Hypoalphalipoproteinemia (HP:0003233)3.10015337
22Hypoglycemic coma (HP:0001325)3.06320199
23Hypolipoproteinemia (HP:0010981)3.05744898
24Abnormality of purine metabolism (HP:0004352)3.05641328
25Polycythemia (HP:0001901)2.97508456
26Abnormality of the intrinsic pathway (HP:0010989)2.97231041
27Flat acetabular roof (HP:0003180)2.87695808
28Distal upper limb amyotrophy (HP:0007149)2.87619658
29Upper limb amyotrophy (HP:0009129)2.87619658
30Atrophic scars (HP:0001075)2.85432390
31Aortic dissection (HP:0002647)2.83946162
32Protrusio acetabuli (HP:0003179)2.81621487
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79462896
34Abnormality of the common coagulation pathway (HP:0010990)2.79092655
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.76562206
36Abnormality of serum amino acid levels (HP:0003112)2.72987709
37Increased purine levels (HP:0004368)2.72015030
38Hyperuricemia (HP:0002149)2.72015030
39Wormian bones (HP:0002645)2.71883413
40Myocardial infarction (HP:0001658)2.70945780
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67435938
42Nonimmune hydrops fetalis (HP:0001790)2.60274162
43Systemic lupus erythematosus (HP:0002725)2.60169613
44Spinal rigidity (HP:0003306)2.59141724
45Distal lower limb amyotrophy (HP:0008944)2.57617885
46Osteolytic defects of the hand bones (HP:0009699)2.57047563
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.57047563
48Ketosis (HP:0001946)2.56487441
49Abnormality of carpal bone ossification (HP:0006257)2.55862228
50Abnormality of nucleobase metabolism (HP:0010932)2.55769352
51Abnormal cartilage morphology (HP:0002763)2.54253016
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54194980
53Dicarboxylic aciduria (HP:0003215)2.54194980
54Joint hemorrhage (HP:0005261)2.52363707
55Cardiovascular calcification (HP:0011915)2.51384725
56Vascular calcification (HP:0004934)2.50972489
57Hand muscle atrophy (HP:0009130)2.50936179
58Fat malabsorption (HP:0002630)2.50406411
59Hyperacusis (HP:0010780)2.49656128
60Abnormality of complement system (HP:0005339)2.49645563
61Abnormality of the acetabulum (HP:0003170)2.48133621
62Generalized aminoaciduria (HP:0002909)2.45719432
63Esophageal varix (HP:0002040)2.45599596
64Distal lower limb muscle weakness (HP:0009053)2.44727760
65Abnormality of dentin (HP:0010299)2.37725162
66Abnormal ossification of hand bones (HP:0005921)2.35477119
67Shallow orbits (HP:0000586)2.35202601
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34099573
69Ankle contracture (HP:0006466)2.34008446
70Ulnar bowing (HP:0003031)2.32729214
71Pustule (HP:0200039)2.32292519
72Bladder diverticulum (HP:0000015)2.30831112
73Alopecia of scalp (HP:0002293)2.28946081
74Nausea (HP:0002018)2.27749885
75Vacuolated lymphocytes (HP:0001922)2.26638821
76Neurofibrillary tangles (HP:0002185)2.26389757
77Blue sclerae (HP:0000592)2.26345216
78Abnormality of proline metabolism (HP:0010907)2.26143849
79Hydroxyprolinuria (HP:0003080)2.26143849
80Back pain (HP:0003418)2.24204214
81Fragile skin (HP:0001030)2.23753838
82Neonatal short-limb short stature (HP:0008921)2.22407939
83Increased connective tissue (HP:0009025)2.20859949
84Mitral regurgitation (HP:0001653)2.19530921
85Cervical subluxation (HP:0003308)2.18357039
86Amyloidosis (HP:0011034)2.18182889
87Menorrhagia (HP:0000132)2.18035218
88Broad face (HP:0000283)2.17584151
89Urinary glycosaminoglycan excretion (HP:0003541)2.17184917
90Hyperglycemia (HP:0003074)2.16097159
91Coxa vara (HP:0002812)2.15489030
92Proximal tubulopathy (HP:0000114)2.15283476
93Achilles tendon contracture (HP:0001771)2.15169439
94Hypercholesterolemia (HP:0003124)2.14704142
95Short nail (HP:0001799)2.14303591
96Glomerulonephritis (HP:0000099)2.13671215
97Epidermoid cyst (HP:0200040)2.13349775
98Hepatocellular carcinoma (HP:0001402)2.11806885
99Abnormality of the Achilles tendon (HP:0005109)2.11183365
100Cerebral inclusion bodies (HP:0100314)2.09875645
101Lethargy (HP:0001254)2.06628737
102Abnormality of the distal phalanges of the toes (HP:0010182)2.04037991
103Axonal loss (HP:0003447)2.02721322
104Abnormality of polysaccharide metabolism (HP:0011012)2.00031772
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00031772
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00031772
107Irritability (HP:0000737)1.99463595
108Aneurysm (HP:0002617)1.98287761
109Abnormality of methionine metabolism (HP:0010901)1.97602002
110Nephritis (HP:0000123)1.97245944
111Ketoacidosis (HP:0001993)1.96298035
112Abnormality of glycosphingolipid metabolism (HP:0004343)1.95732760
113Abnormality of glycolipid metabolism (HP:0010969)1.95732760
114Abnormality of liposaccharide metabolism (HP:0010968)1.95732760
115Steatorrhea (HP:0002570)1.95477900
116Chondrocalcinosis (HP:0000934)1.94411588
117Mildly elevated creatine phosphokinase (HP:0008180)1.93629907
118Malnutrition (HP:0004395)1.92939323
119Right ventricular cardiomyopathy (HP:0011663)1.92855892
120Mitral stenosis (HP:0001718)1.92215182
121Dilatation of the ascending aorta (HP:0005111)1.90967209
122Abnormal enzyme/coenzyme activity (HP:0012379)1.90165130
123Asymmetry of the thorax (HP:0001555)1.89479919
124Atrioventricular block (HP:0001678)1.89314859
125Elbow flexion contracture (HP:0002987)1.87694972
126Beaking of vertebral bodies (HP:0004568)1.87060740
127Natal tooth (HP:0000695)1.87037992
128Delayed CNS myelination (HP:0002188)1.86910048
129Interstitial pulmonary disease (HP:0006530)1.86458533
130Aortic aneurysm (HP:0004942)1.86399707
131Disproportionate tall stature (HP:0001519)1.85832633
132J-shaped sella turcica (HP:0002680)1.85572923
133Abnormal hand bone ossification (HP:0010660)1.85232494
134Joint laxity (HP:0001388)1.85222528
135Abnormal delivery (HP:0001787)1.84407395
136Skin nodule (HP:0200036)1.84372023
137Multiple enchondromatosis (HP:0005701)1.83564578
138Biconcave vertebral bodies (HP:0004586)1.83416452
139Hypoplasia of the iris (HP:0007676)1.82833607
140Vertebral compression fractures (HP:0002953)1.82622156
141Protuberant abdomen (HP:0001538)1.81540208
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80584967
143Vertebral hypoplasia (HP:0008417)1.80584967
144Spastic diplegia (HP:0001264)1.80113214
145Muscle fiber splitting (HP:0003555)1.79914567
146Hemorrhage of the eye (HP:0011885)1.79101095
147Nuclear cataract (HP:0100018)1.78896669
148Soft skin (HP:0000977)1.77570496
149Peritonitis (HP:0002586)1.77539477
150Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76872549
151Lower limb amyotrophy (HP:0007210)1.76710730
152Abnormality of alkaline phosphatase activity (HP:0004379)1.76497812
153Cupped ribs (HP:0000887)1.76275135
154Cerebral aneurysm (HP:0004944)1.75197175
155Joint stiffness (HP:0001387)1.75007854
156Conjugated hyperbilirubinemia (HP:0002908)1.74963597
157Dysostosis multiplex (HP:0000943)1.74689292
158Hyperbilirubinemia (HP:0002904)1.72750408
159Abnormality of Sharpey fibers (HP:0100685)1.72224751
160Metabolic acidosis (HP:0001942)1.71845649
161Stroke (HP:0001297)1.70810988
162Thin bony cortex (HP:0002753)1.70414309
163Hyperextensible skin (HP:0000974)1.70388334
164Mucopolysacchariduria (HP:0008155)1.70045395
165Long toe (HP:0010511)1.69952630
166Difficulty climbing stairs (HP:0003551)1.69860543
167Purpura (HP:0000979)1.69116042
168Flattened epiphyses (HP:0003071)1.69110298
169Vertebral arch anomaly (HP:0008438)1.69032444
170Ovoid vertebral bodies (HP:0003300)1.68536296
171Growth hormone excess (HP:0000845)1.66031963
172Spondylolisthesis (HP:0003302)1.65435916
173Renal duplication (HP:0000075)1.65227132
174Insomnia (HP:0100785)1.65153106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.87393821
2TRIB33.75370645
3BCKDK3.40591972
4TESK13.20653087
5EPHA22.81675692
6ICK2.60270657
7TIE12.58569936
8KDR2.26545537
9LIMK12.24259744
10TGFBR22.14338706
11LMTK22.13431234
12FGFR42.11601836
13NME22.08206694
14TESK22.00263583
15MAP3K31.94772121
16NTRK11.92860701
17BUB11.89486261
18LATS11.87279553
19STK38L1.83971614
20PDK21.83257928
21SIK11.81738770
22ACVR1B1.75215492
23MST1R1.75159489
24NEK91.69945466
25PKN21.68091715
26AKT31.65795088
27STK31.63124990
28SCYL21.62251980
29PIM21.57866645
30IRAK31.56110099
31SMG11.50838946
32PRPF4B1.45830522
33PDK41.41077811
34PDK31.41077811
35TTN1.36997381
36RPS6KA41.31850967
37PTK61.31273793
38TBK11.28457511
39WEE11.27940081
40LRRK21.25717987
41MAP2K21.18064232
42DDR21.17425322
43MAP2K31.15191282
44PDGFRA1.15036153
45MAP3K61.09340006
46TYK21.09264802
47PAK41.08935847
48TAOK21.08426519
49MYLK1.05620859
50EPHB11.05036772
51ABL21.02589270
52EIF2AK11.00640608
53FLT31.00118645
54STK380.99929865
55PTK20.98460543
56BRSK20.98420665
57MET0.97404337
58NUAK10.96611551
59STK100.95831874
60FRK0.95039376
61RIPK10.91617852
62ERBB40.88620196
63TGFBR10.88053818
64RET0.86888293
65PAK20.82666492
66ROCK20.82441144
67NEK20.81730511
68LATS20.81296952
69TSSK60.79159111
70PRKD20.77245553
71KSR20.76882180
72ILK0.75901123
73CDK120.75269012
74CDC42BPA0.74901912
75PIK3CG0.74649248
76MAP3K20.73290286
77PINK10.73195552
78PDGFRB0.72919161
79TAOK30.72071245
80EPHB20.69685596
81MAPK110.69090525
82MAPKAPK30.68642156
83PBK0.67225597
84MAP2K10.66739488
85KIT0.66061567
86JAK10.66013979
87DMPK0.65256029
88RPS6KA20.64663873
89ZAK0.63326754
90ZAP700.63232529
91MAP3K10.60908104
92JAK20.59261004
93EEF2K0.59200912
94WNK40.58814337
95NEK10.58390319
96CDK60.58289037
97CDK70.58281234
98GSK3A0.57651423
99MAP3K80.57509628
100FGFR30.57119863
101FER0.56209592
102JAK30.55392001
103MTOR0.54064182
104TYRO30.54000903
105WNK30.53046158
106MAP3K110.52874506
107MAPK150.52321576
108EPHA30.50216162
109EIF2AK30.49886013
110DYRK30.49391787
111BMX0.48987810
112PLK40.47724953
113STK240.47333696
114TRPM70.46798865
115DYRK1B0.45432157
116MAP3K120.45129600
117PRKD30.44524782
118CSK0.43919115
119CDK80.43227943
120SRC0.42867563
121PIM10.42850215
122PRKD10.42030171
123ARAF0.41452824
124MOS0.40875639
125PRKAA10.40669096
126CDK140.40543430
127PRKAA20.40201120
128ROCK10.39537749
129GRK10.39396528
130IKBKB0.39224979
131PDPK10.39001951
132PAK10.38904310
133PRKG20.38474034
134CDK40.38106789
135CAMK2G0.37483746
136CDK90.37008662
137MARK20.35780896
138CDK150.35753348
139INSRR0.35722561
140NLK0.35475036
141CDK11A0.34807728
142AKT20.34697411
143TAOK10.34444376
144CDK180.34085320
145MAPKAPK20.33756165
146CHUK0.32577571
147PAK60.31615463
148DAPK30.31143922

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.14914418
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.97418104
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92026186
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58034801
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54056462
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.51553583
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49698978
8Fatty acid degradation_Homo sapiens_hsa000712.48186760
9Nitrogen metabolism_Homo sapiens_hsa009102.48063965
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37276523
11Folate biosynthesis_Homo sapiens_hsa007902.26303219
12Complement and coagulation cascades_Homo sapiens_hsa046102.17544084
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.11078960
14Tryptophan metabolism_Homo sapiens_hsa003802.06389417
15Arginine biosynthesis_Homo sapiens_hsa002201.95360126
16Vitamin digestion and absorption_Homo sapiens_hsa049771.94759099
17PPAR signaling pathway_Homo sapiens_hsa033201.91009037
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.87409587
19Fatty acid metabolism_Homo sapiens_hsa012121.86423321
20Peroxisome_Homo sapiens_hsa041461.80132376
21Butanoate metabolism_Homo sapiens_hsa006501.80109674
22Sulfur metabolism_Homo sapiens_hsa009201.75520147
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.75040333
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72561798
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72271867
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71857279
27Selenocompound metabolism_Homo sapiens_hsa004501.70694361
28Propanoate metabolism_Homo sapiens_hsa006401.70054754
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69236735
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63047798
31Adherens junction_Homo sapiens_hsa045201.59708735
32Chemical carcinogenesis_Homo sapiens_hsa052041.57333189
33Vibrio cholerae infection_Homo sapiens_hsa051101.53982880
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.53466638
35beta-Alanine metabolism_Homo sapiens_hsa004101.51858383
36Staphylococcus aureus infection_Homo sapiens_hsa051501.50992446
37Caffeine metabolism_Homo sapiens_hsa002321.45360927
38Histidine metabolism_Homo sapiens_hsa003401.42943472
39Proteoglycans in cancer_Homo sapiens_hsa052051.41949923
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39448252
41Retinol metabolism_Homo sapiens_hsa008301.39441522
42N-Glycan biosynthesis_Homo sapiens_hsa005101.39369943
43Sulfur relay system_Homo sapiens_hsa041221.38013734
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37931981
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36635530
46Chronic myeloid leukemia_Homo sapiens_hsa052201.34460034
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.28521172
48Pentose phosphate pathway_Homo sapiens_hsa000301.27673214
49Carbon metabolism_Homo sapiens_hsa012001.27365092
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.26480449
51Biosynthesis of amino acids_Homo sapiens_hsa012301.25530046
52Starch and sucrose metabolism_Homo sapiens_hsa005001.23812687
53Notch signaling pathway_Homo sapiens_hsa043301.22538447
54Fat digestion and absorption_Homo sapiens_hsa049751.22206975
55Pancreatic cancer_Homo sapiens_hsa052121.20644658
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19880976
57Thyroid cancer_Homo sapiens_hsa052161.18700926
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16068192
59Glutathione metabolism_Homo sapiens_hsa004801.14102031
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.13817348
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.11737404
62Bile secretion_Homo sapiens_hsa049761.09925207
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09665096
64Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08089233
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06820165
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06037434
67Shigellosis_Homo sapiens_hsa051311.03273171
68Sphingolipid metabolism_Homo sapiens_hsa006001.01760562
69Arginine and proline metabolism_Homo sapiens_hsa003301.00929548
70Endometrial cancer_Homo sapiens_hsa052131.00154728
71Fatty acid elongation_Homo sapiens_hsa000620.99831898
72Endocytosis_Homo sapiens_hsa041440.98452308
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95873316
74Dilated cardiomyopathy_Homo sapiens_hsa054140.95246681
75Pyruvate metabolism_Homo sapiens_hsa006200.94998492
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93238485
77Steroid biosynthesis_Homo sapiens_hsa001000.92942837
78Salmonella infection_Homo sapiens_hsa051320.92264209
79Glycerolipid metabolism_Homo sapiens_hsa005610.92112648
80Lysosome_Homo sapiens_hsa041420.92008180
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90776848
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90168796
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89539614
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88863567
85Phenylalanine metabolism_Homo sapiens_hsa003600.87918259
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86689149
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81932355
88Fructose and mannose metabolism_Homo sapiens_hsa000510.78603956
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78517936
90Non-small cell lung cancer_Homo sapiens_hsa052230.78252297
91Hippo signaling pathway_Homo sapiens_hsa043900.76215208
92Renal cell carcinoma_Homo sapiens_hsa052110.75777882
93Tight junction_Homo sapiens_hsa045300.72840222
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71492672
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.70778878
96ABC transporters_Homo sapiens_hsa020100.70511424
97Tyrosine metabolism_Homo sapiens_hsa003500.69431855
98Phagosome_Homo sapiens_hsa041450.69365973
99Regulation of autophagy_Homo sapiens_hsa041400.67262792
100Other glycan degradation_Homo sapiens_hsa005110.67121588
101Axon guidance_Homo sapiens_hsa043600.65724811
102Galactose metabolism_Homo sapiens_hsa000520.64937842
103Pertussis_Homo sapiens_hsa051330.64416364
104VEGF signaling pathway_Homo sapiens_hsa043700.63503383
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.62605113
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.62541413
107MicroRNAs in cancer_Homo sapiens_hsa052060.62474786
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.62316512
109Insulin signaling pathway_Homo sapiens_hsa049100.59852966
110HIF-1 signaling pathway_Homo sapiens_hsa040660.59284186
111Thyroid hormone synthesis_Homo sapiens_hsa049180.58655622
112ECM-receptor interaction_Homo sapiens_hsa045120.58537397
113Pathways in cancer_Homo sapiens_hsa052000.58233554
114Acute myeloid leukemia_Homo sapiens_hsa052210.58040266
115Glioma_Homo sapiens_hsa052140.57755714
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57252469
117Gap junction_Homo sapiens_hsa045400.55787099
118ErbB signaling pathway_Homo sapiens_hsa040120.54692764
119Hepatitis C_Homo sapiens_hsa051600.54114693
120Mineral absorption_Homo sapiens_hsa049780.52713343
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51403170
122Apoptosis_Homo sapiens_hsa042100.51249059
123Metabolic pathways_Homo sapiens_hsa011000.49565892
124Prostate cancer_Homo sapiens_hsa052150.48367628
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.48177549
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47781196
127Renin-angiotensin system_Homo sapiens_hsa046140.47742664
128Fatty acid biosynthesis_Homo sapiens_hsa000610.46942332
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.45116493
130Protein digestion and absorption_Homo sapiens_hsa049740.44414567
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.44214584
132Rap1 signaling pathway_Homo sapiens_hsa040150.42233154
133Lysine degradation_Homo sapiens_hsa003100.41218991
134Melanogenesis_Homo sapiens_hsa049160.40749540
135Legionellosis_Homo sapiens_hsa051340.40563742
136Insulin resistance_Homo sapiens_hsa049310.39386922
137Colorectal cancer_Homo sapiens_hsa052100.39207420
138Malaria_Homo sapiens_hsa051440.37491112
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36605668
140One carbon pool by folate_Homo sapiens_hsa006700.34745412
141Arachidonic acid metabolism_Homo sapiens_hsa005900.32745565
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32562210
143Prion diseases_Homo sapiens_hsa050200.30766786
144Small cell lung cancer_Homo sapiens_hsa052220.27658982
145p53 signaling pathway_Homo sapiens_hsa041150.25755769
146Bladder cancer_Homo sapiens_hsa052190.23709348
147Amoebiasis_Homo sapiens_hsa051460.22863277
148Linoleic acid metabolism_Homo sapiens_hsa005910.20883660
149Proteasome_Homo sapiens_hsa030500.18866452
150Focal adhesion_Homo sapiens_hsa045100.18000537
151Pyrimidine metabolism_Homo sapiens_hsa002400.14889568
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13948887
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13546134
154Antigen processing and presentation_Homo sapiens_hsa046120.12878702
155AMPK signaling pathway_Homo sapiens_hsa041520.12327655
156RNA polymerase_Homo sapiens_hsa030200.10472305

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