PTTG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.06466485
2positive thymic T cell selection (GO:0045059)4.39078677
3cellular extravasation (GO:0045123)4.26839637
4immunoglobulin mediated immune response (GO:0016064)4.23449724
5iron-sulfur cluster assembly (GO:0016226)4.12782465
6metallo-sulfur cluster assembly (GO:0031163)4.12782465
7positive regulation of toll-like receptor signaling pathway (GO:0034123)4.10594423
8positive regulation of prostaglandin secretion (GO:0032308)4.09666556
9sleep (GO:0030431)4.09638629
10negative thymic T cell selection (GO:0045060)4.01482151
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00198755
12negative regulation of cell killing (GO:0031342)4.00198755
13DNA deamination (GO:0045006)3.93471111
14tyrosine phosphorylation of STAT protein (GO:0007260)3.92685084
15microglial cell activation (GO:0001774)3.88228178
16negative T cell selection (GO:0043383)3.86499148
17neutrophil activation involved in immune response (GO:0002283)3.80379690
18positive regulation of heat generation (GO:0031652)3.78665230
19adult feeding behavior (GO:0008343)3.76965053
20positive regulation of mast cell activation involved in immune response (GO:0033008)3.68783991
21positive regulation of mast cell degranulation (GO:0043306)3.68783991
22positive regulation of mast cell activation (GO:0033005)3.68612438
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64668120
24leukocyte degranulation (GO:0043299)3.63019211
25mast cell activation (GO:0045576)3.54272667
26retinal cone cell development (GO:0046549)3.53096607
27mast cell activation involved in immune response (GO:0002279)3.51997901
28mast cell degranulation (GO:0043303)3.51997901
29natural killer cell activation involved in immune response (GO:0002323)3.51535921
30positive regulation of gamma-delta T cell activation (GO:0046645)3.50493605
31cellular response to interleukin-15 (GO:0071350)3.48285556
32negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.48162547
33respiratory burst (GO:0045730)3.45489574
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38401896
35regulation of prostaglandin secretion (GO:0032306)3.37022304
36positive T cell selection (GO:0043368)3.36902476
37regulation of fever generation (GO:0031620)3.36371075
38regulation of mast cell activation (GO:0033003)3.34870297
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29365425
40positive regulation of interleukin-8 secretion (GO:2000484)3.28958789
41lymph node development (GO:0048535)3.27552516
42detection of molecule of bacterial origin (GO:0032490)3.25126692
43interferon-gamma-mediated signaling pathway (GO:0060333)3.24797884
44antigen processing and presentation of endogenous antigen (GO:0019883)3.24284235
45regulation of gamma-delta T cell differentiation (GO:0045586)3.22101199
46negative regulation of B cell proliferation (GO:0030889)3.20218063
47neutrophil activation (GO:0042119)3.19377773
48T cell migration (GO:0072678)3.17986718
49myeloid cell activation involved in immune response (GO:0002275)3.15514892
50positive regulation of T cell differentiation in thymus (GO:0033089)3.13838249
51B cell mediated immunity (GO:0019724)3.08015463
52defense response to protozoan (GO:0042832)3.07745061
53lymphocyte chemotaxis (GO:0048247)3.07618496
54response to interleukin-15 (GO:0070672)3.03200650
55regulation of gamma-delta T cell activation (GO:0046643)3.01328952
56sequestering of actin monomers (GO:0042989)2.97483363
57thrombin receptor signaling pathway (GO:0070493)2.97113596
58purine deoxyribonucleotide catabolic process (GO:0009155)2.96889017
59regulation of alpha-beta T cell proliferation (GO:0046640)2.96099396
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91924539
61regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.91745773
62positive regulation of antigen processing and presentation (GO:0002579)2.91569225
63protein neddylation (GO:0045116)2.87142248
64negative regulation of T cell mediated immunity (GO:0002710)2.85849943
65positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84846506
66T cell receptor signaling pathway (GO:0050852)2.82660684
67tolerance induction (GO:0002507)2.82344628
68granulocyte activation (GO:0036230)2.81156994
69positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.80091445
70killing of cells of other organism (GO:0031640)2.79736969
71disruption of cells of other organism (GO:0044364)2.79736969
72neutrophil mediated immunity (GO:0002446)2.79508932
73negative regulation of cAMP-mediated signaling (GO:0043951)2.77759367
74regulation of interleukin-6 biosynthetic process (GO:0045408)2.76483784
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76095945
76negative regulation of T-helper cell differentiation (GO:0045623)2.76095945
77adenosine metabolic process (GO:0046085)2.75983658
78antigen receptor-mediated signaling pathway (GO:0050851)2.74293969
79regulation of heat generation (GO:0031650)2.74132671
80negative regulation of alpha-beta T cell differentiation (GO:0046639)2.73434363
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.72829690
82modulation by symbiont of host immune response (GO:0052553)2.72829690
83positive regulation by symbiont of host defense response (GO:0052509)2.72829690
84modulation by symbiont of host defense response (GO:0052031)2.72829690
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.72829690
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.72829690
87regulation of mast cell activation involved in immune response (GO:0033006)2.72708752
88B cell receptor signaling pathway (GO:0050853)2.72194591
89positive regulation of fatty acid transport (GO:2000193)2.71598543
90T cell costimulation (GO:0031295)2.71256082
91regulation of interleukin-8 secretion (GO:2000482)2.71156044
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.70221367
93negative regulation of NF-kappaB import into nucleus (GO:0042347)2.70038850
94negative regulation of alpha-beta T cell activation (GO:0046636)2.70004993
95tumor necrosis factor-mediated signaling pathway (GO:0033209)2.69260057
96lymphocyte costimulation (GO:0031294)2.67713682
97macrophage activation (GO:0042116)2.67642800
98negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67188911
99positive regulation of icosanoid secretion (GO:0032305)2.66212876
100regulation of B cell proliferation (GO:0030888)2.64639100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.50342417
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.37272096
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.12402074
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.01075800
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83132986
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21767660
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09286500
8EZH2_22144423_ChIP-Seq_EOC_Human3.05479074
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83976831
10* RUNX_20019798_ChIP-Seq_JUKART_Human2.76892744
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.36711171
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.32869031
13MYB_26560356_Chip-Seq_TH2_Human2.29319571
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.26350746
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25364472
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16308695
17GATA3_26560356_Chip-Seq_TH2_Human2.08683371
18SPI1_23547873_ChIP-Seq_NB4_Human2.08004956
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02879495
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99806883
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90469966
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88032554
23GATA3_27048872_Chip-Seq_THYMUS_Human1.78428225
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75924360
25IRF1_19129219_ChIP-ChIP_H3396_Human1.73580823
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72453999
27GATA1_22025678_ChIP-Seq_K562_Human1.63974755
28MYB_26560356_Chip-Seq_TH1_Human1.58519408
29VDR_23849224_ChIP-Seq_CD4+_Human1.54745422
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53645986
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50600763
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50298428
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45705041
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45098089
35TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.43105007
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39220199
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38887786
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.38727468
39AR_21572438_ChIP-Seq_LNCaP_Human1.38436582
40* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36967640
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36250961
42MAF_26560356_Chip-Seq_TH1_Human1.36236021
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.33576038
44TP53_22573176_ChIP-Seq_HFKS_Human1.32885776
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.32628625
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32416861
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30976791
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29565215
49FOXH1_21741376_ChIP-Seq_EPCs_Human1.29002650
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24518782
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22399144
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.21975448
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.21470743
54ER_23166858_ChIP-Seq_MCF-7_Human1.20719835
55VDR_24787735_ChIP-Seq_THP-1_Human1.19745883
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.18911087
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18911087
58GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.16681471
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.16437390
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16359162
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16155230
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13122019
63* SOX2_19829295_ChIP-Seq_ESCs_Human1.10033483
64* NANOG_19829295_ChIP-Seq_ESCs_Human1.10033483
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08857799
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.08685137
67ZNF274_21170338_ChIP-Seq_K562_Hela1.06985473
68RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05426325
69CIITA_25753668_ChIP-Seq_RAJI_Human1.05281259
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05038330
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04959472
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.04881047
73AR_20517297_ChIP-Seq_VCAP_Human1.03839899
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03696569
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03662984
76SALL4_22934838_ChIP-ChIP_CD34+_Human1.03612113
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03575216
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.01386117
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01125342
80FOXP3_21729870_ChIP-Seq_TREG_Human1.00681624
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98271830
82* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97121527
83GBX2_23144817_ChIP-Seq_PC3_Human0.96869412
84* P300_19829295_ChIP-Seq_ESCs_Human0.96655329
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95248317
86BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95096662
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95042742
88SCL_19346495_ChIP-Seq_HPC-7_Human0.93231927
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93099384
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92696568
91* BCAT_22108803_ChIP-Seq_LS180_Human0.91827884
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90963814
93GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90796918
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88646937
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86916071
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.86419226
97VDR_24763502_ChIP-Seq_THP-1_Human0.86100446
98* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86003003
99* CDX2_22108803_ChIP-Seq_LS180_Human0.85242720
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84958730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.81946586
2MP0003724_increased_susceptibility_to3.84394005
3MP0000569_abnormal_digit_pigmentation3.49787341
4MP0005671_abnormal_response_to3.43123752
5MP0000685_abnormal_immune_system2.83456607
6MP0002138_abnormal_hepatobiliary_system2.73389993
7MP0001800_abnormal_humoral_immune2.70399230
8MP0005075_abnormal_melanosome_morpholog2.61024499
9MP0005000_abnormal_immune_tolerance2.57153622
10MP0009379_abnormal_foot_pigmentation2.55175534
11MP0003436_decreased_susceptibility_to2.55118723
12MP0003195_calcinosis2.51957712
13MP0002723_abnormal_immune_serum2.33509891
14MP0002452_abnormal_antigen_presenting2.28287876
15MP0001819_abnormal_immune_cell2.25549271
16MP0009785_altered_susceptibility_to2.22416889
17MP0006082_CNS_inflammation2.19727796
18MP0002420_abnormal_adaptive_immunity2.17552216
19MP0002419_abnormal_innate_immunity2.15975796
20MP0003183_abnormal_peptide_metabolism2.08244001
21MP0006292_abnormal_olfactory_placode2.05152721
22MP0008877_abnormal_DNA_methylation2.02825260
23MP0001790_abnormal_immune_system1.96435962
24MP0005387_immune_system_phenotype1.96435962
25MP0002277_abnormal_respiratory_mucosa1.95328718
26MP0003763_abnormal_thymus_physiology1.92746330
27MP0005025_abnormal_response_to1.86292392
28MP0009764_decreased_sensitivity_to1.84889301
29MP0003283_abnormal_digestive_organ1.80531553
30MP0002148_abnormal_hypersensitivity_rea1.78428792
31MP0002405_respiratory_system_inflammati1.69109770
32MP0002653_abnormal_ependyma_morphology1.69076342
33MP0000716_abnormal_immune_system1.68786167
34MP0002166_altered_tumor_susceptibility1.68773423
35MP0002102_abnormal_ear_morphology1.67435170
36MP0002396_abnormal_hematopoietic_system1.60524121
37MP0002398_abnormal_bone_marrow1.59629254
38MP0005171_absent_coat_pigmentation1.59624883
39MP0005464_abnormal_platelet_physiology1.58161925
40MP0001533_abnormal_skeleton_physiology1.55967599
41MP0003866_abnormal_defecation1.51840671
42MP0000689_abnormal_spleen_morphology1.49404441
43MP0003878_abnormal_ear_physiology1.49146336
44MP0005377_hearing/vestibular/ear_phenot1.49146336
45MP0003656_abnormal_erythrocyte_physiolo1.49099942
46MP0000465_gastrointestinal_hemorrhage1.44531377
47MP0002722_abnormal_immune_system1.41161241
48MP0003787_abnormal_imprinting1.39619648
49MP0004043_abnormal_pH_regulation1.38858784
50MP0000566_synostosis1.33136524
51MP0002933_joint_inflammation1.32065475
52MP0001853_heart_inflammation1.31416093
53MP0002429_abnormal_blood_cell1.29263940
54MP0004510_myositis1.26356008
55MP0008961_abnormal_basal_metabolism1.25436308
56MP0002006_tumorigenesis1.20497233
57MP0001845_abnormal_inflammatory_respons1.20443582
58MP0003303_peritoneal_inflammation1.16455295
59MP0002009_preneoplasia1.08544381
60MP0001529_abnormal_vocalization1.07331102
61MP0000703_abnormal_thymus_morphology1.06220770
62MP0004885_abnormal_endolymph1.03240418
63MP0003646_muscle_fatigue0.99478917
64MP0002822_catalepsy0.98327498
65MP0003252_abnormal_bile_duct0.97613985
66MP0001851_eye_inflammation0.96954648
67MP0006072_abnormal_retinal_apoptosis0.95011778
68MP0002998_abnormal_bone_remodeling0.90624009
69MP0004883_abnormal_blood_vessel0.90203091
70MP0004484_altered_response_of0.87450941
71MP0010155_abnormal_intestine_physiology0.85743996
72MP0003075_altered_response_to0.84607945
73MP0001663_abnormal_digestive_system0.83313470
74MP0006054_spinal_hemorrhage0.79860090
75MP0008469_abnormal_protein_level0.79677993
76MP0004947_skin_inflammation0.76208675
77MP0006276_abnormal_autonomic_nervous0.76049099
78MP0005084_abnormal_gallbladder_morpholo0.74585683
79MP0002332_abnormal_exercise_endurance0.74034549
80MP0001324_abnormal_eye_pigmentation0.73823234
81MP0005390_skeleton_phenotype0.72682989
82MP0003950_abnormal_plasma_membrane0.72480464
83MP0000372_irregular_coat_pigmentation0.72101123
84MP0004381_abnormal_hair_follicle0.71424812
85MP0008057_abnormal_DNA_replication0.70993969
86MP0001873_stomach_inflammation0.70818399
87MP0005174_abnormal_tail_pigmentation0.69872856
88MP0001501_abnormal_sleep_pattern0.69340756
89MP0003828_pulmonary_edema0.65855124
90MP0002132_abnormal_respiratory_system0.65249477
91MP0003186_abnormal_redox_activity0.64881063
92MP0003011_delayed_dark_adaptation0.63930690
93MP0001293_anophthalmia0.62946284
94MP0002938_white_spotting0.61460915
95MP0009765_abnormal_xenobiotic_induced0.60754889
96MP0005310_abnormal_salivary_gland0.60060065
97MP0002928_abnormal_bile_duct0.59078321
98MP0002234_abnormal_pharynx_morphology0.58856174
99MP0005253_abnormal_eye_physiology0.58586869
100MP0005166_decreased_susceptibility_to0.58009173

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)5.01128069
2Chronic obstructive pulmonary disease (HP:0006510)4.14010548
3Obstructive lung disease (HP:0006536)4.14010548
4Hemoptysis (HP:0002105)3.98822488
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.79726108
6Absent/shortened dynein arms (HP:0200106)3.79726108
7Abnormality of the prostate (HP:0008775)3.79511549
8Chronic mucocutaneous candidiasis (HP:0002728)3.75921769
9Recurrent cutaneous fungal infections (HP:0011370)3.75921769
10Elevated erythrocyte sedimentation rate (HP:0003565)3.73316249
11Myositis (HP:0100614)3.68425812
12T lymphocytopenia (HP:0005403)3.57772664
13Vasculitis (HP:0002633)3.46315059
14Retrobulbar optic neuritis (HP:0100654)3.44692679
15Optic neuritis (HP:0100653)3.44692679
16Recurrent fungal infections (HP:0002841)3.42551758
17Abnormality of T cell number (HP:0011839)3.32443184
18Orchitis (HP:0100796)3.31498392
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.29755729
20Constricted visual fields (HP:0001133)3.23811722
21Recurrent bacterial skin infections (HP:0005406)3.23749205
22Stomatitis (HP:0010280)3.20791082
23Meningitis (HP:0001287)3.20117393
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01572887
25Panhypogammaglobulinemia (HP:0003139)2.94630655
26Absent thumb (HP:0009777)2.89434132
27Abnormality of T cells (HP:0002843)2.89018436
28Stomach cancer (HP:0012126)2.87098144
29Glomerulopathy (HP:0100820)2.84008495
30Mediastinal lymphadenopathy (HP:0100721)2.80671780
31Hypomagnesemia (HP:0002917)2.80107120
32Gangrene (HP:0100758)2.77866784
33Recurrent bronchitis (HP:0002837)2.77648318
34Peritonitis (HP:0002586)2.76764611
35Recurrent skin infections (HP:0001581)2.71929191
36Chest pain (HP:0100749)2.70544745
37Abnormality of the pleura (HP:0002103)2.67300648
38Abnormality of transition element cation homeostasis (HP:0011030)2.64166975
39Pulmonary infiltrates (HP:0002113)2.60180006
40Abnormality of iron homeostasis (HP:0011031)2.59020178
41Hypothermia (HP:0002045)2.56852245
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56801784
43Prostate neoplasm (HP:0100787)2.53275626
44IgG deficiency (HP:0004315)2.50879492
45Keratoconjunctivitis (HP:0001096)2.50452248
46Anorexia (HP:0002039)2.46684269
47Periorbital edema (HP:0100539)2.46225252
48Pancytopenia (HP:0001876)2.44419777
49Keratoconjunctivitis sicca (HP:0001097)2.43654513
50Recurrent abscess formation (HP:0002722)2.43311315
51Pulmonary embolism (HP:0002204)2.42996833
52Encephalitis (HP:0002383)2.41914167
53Arterial thrombosis (HP:0004420)2.40708847
54Facial edema (HP:0000282)2.35798401
55Ureteral obstruction (HP:0006000)2.35509710
56Polyneuropathy (HP:0001271)2.28886118
57Reticulocytopenia (HP:0001896)2.25712323
58Pulmonary fibrosis (HP:0002206)2.23207379
59Hypoplastic nipples (HP:0002557)2.21658654
60Leukocytosis (HP:0001974)2.17818479
61Abnormality of male internal genitalia (HP:0000022)2.16401586
62Pustule (HP:0200039)2.16053878
63Eczematoid dermatitis (HP:0000976)2.14305739
64Carpal bone hypoplasia (HP:0001498)2.09920161
65Birth length less than 3rd percentile (HP:0003561)2.09881935
66Limb hypertonia (HP:0002509)2.08947409
67Abnormality of magnesium homeostasis (HP:0004921)2.08909203
68Recurrent viral infections (HP:0004429)2.08648546
69Abnormality of the pericardium (HP:0001697)2.08550068
70Spontaneous hematomas (HP:0007420)2.08420872
71Abnormality of T cell physiology (HP:0011840)2.07662474
72Papilledema (HP:0001085)2.07006430
73Abnormal ciliary motility (HP:0012262)2.03313506
74Diplopia (HP:0000651)2.02191132
75Abnormality of binocular vision (HP:0011514)2.02191132
76Recurrent pneumonia (HP:0006532)2.02040625
77Urticaria (HP:0001025)2.00429998
78Ureteral stenosis (HP:0000071)1.97540115
79Bronchitis (HP:0012387)1.95913572
80Tetany (HP:0001281)1.95075472
81Abnormal respiratory motile cilium morphology (HP:0005938)1.93086645
82Abnormal respiratory epithelium morphology (HP:0012253)1.93086645
83Delayed closure of the anterior fontanelle (HP:0001476)1.92943735
84Long clavicles (HP:0000890)1.92929509
85Joint swelling (HP:0001386)1.92816781
86Skin rash (HP:0000988)1.84458611
87Septo-optic dysplasia (HP:0100842)1.82701405
88Recurrent sinusitis (HP:0011108)1.82247760
89Restrictive lung disease (HP:0002091)1.82019741
90Cerebral palsy (HP:0100021)1.81499240
91Vertigo (HP:0002321)1.80822721
92Abnormality of macrophages (HP:0004311)1.80387068
93Duplicated collecting system (HP:0000081)1.79130610
94Amaurosis fugax (HP:0100576)1.78619993
95Bilateral microphthalmos (HP:0007633)1.77799722
96Chronic diarrhea (HP:0002028)1.77358205
97Abnormality of midbrain morphology (HP:0002418)1.76918752
98Molar tooth sign on MRI (HP:0002419)1.76918752
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76638862
100Recurrent lower respiratory tract infections (HP:0002783)1.74833963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK64.14707943
2MUSK4.11334670
3ZAK3.53575867
4MAP4K13.16671919
5TXK3.16641171
6KIT3.05510364
7VRK22.79425315
8TAOK32.75844884
9TLK12.33301044
10GRK72.14697308
11TGFBR22.10090696
12IKBKE1.99106885
13BLK1.98321215
14SYK1.92032462
15JAK31.75191230
16MAP3K141.72977799
17GRK51.71746500
18CCNB11.65190875
19STK101.64605486
20CSK1.58363069
21RIPK41.56947558
22BTK1.56790994
23IRAK41.47905485
24MST41.46096648
25IKBKB1.45110484
26MOS1.43542284
27TBK11.36525034
28MAP3K111.31041758
29PASK1.30979355
30OXSR11.21176652
31CDK191.18583786
32FRK1.17443735
33TEC1.16277286
34ITK1.14686416
35FES1.14389986
36EIF2AK21.11870706
37STK161.10568126
38LRRK21.08493636
39VRK11.08387261
40ADRBK21.07082822
41PIK3CA1.06672869
42PINK11.05164108
43LYN1.01074097
44MATK1.00548908
45CAMKK20.99860207
46BMPR20.97464037
47CAMKK10.91861890
48IRAK20.90009475
49CSF1R0.89614430
50TYK20.89402781
51IRAK10.89262183
52MAP2K20.87831446
53ADRBK10.86595652
54ZAP700.86492631
55TAOK10.84448870
56PLK20.84334288
57JAK10.80679810
58MAP3K120.79825452
59MAP3K60.79033955
60PIM10.78390814
61KDR0.76114341
62PRKCQ0.75880926
63LCK0.75386931
64PIK3CG0.73898319
65PDK10.68983851
66JAK20.68390171
67HCK0.67243024
68ACVR1B0.62604708
69STK110.59935644
70MARK30.59638453
71NEK60.57466749
72TNK20.54357888
73GRK10.53648749
74MAPKAPK20.53473491
75ABL10.50529992
76MAPK70.49441108
77RPS6KA60.46523320
78ERBB20.44213705
79WNK30.42924367
80PLK30.41265400
81STK40.41009790
82EGFR0.39774101
83NUAK10.39675207
84MAP4K20.38837842
85MAP2K60.38461622
86CSNK1A1L0.38294216
87CHEK20.38052154
88CDK30.38022465
89PTK2B0.37954316
90MAPK150.35131332
91AURKA0.33778783
92PAK30.32814404
93MAPK130.31793619
94PRKCD0.30456257
95PRKCI0.29743192
96FGR0.28709941
97RPS6KC10.27633709
98RPS6KL10.27633709
99CSNK1G30.27093075
100DYRK20.27068681

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.80451597
2Graft-versus-host disease_Homo sapiens_hsa053324.70385208
3Allograft rejection_Homo sapiens_hsa053304.17695966
4Autoimmune thyroid disease_Homo sapiens_hsa053204.02503731
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.86943195
6Type I diabetes mellitus_Homo sapiens_hsa049403.26153287
7Leishmaniasis_Homo sapiens_hsa051403.14306473
8Antigen processing and presentation_Homo sapiens_hsa046123.05004709
9Staphylococcus aureus infection_Homo sapiens_hsa051502.92731866
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.81062475
11Rheumatoid arthritis_Homo sapiens_hsa053232.25427392
12Primary immunodeficiency_Homo sapiens_hsa053402.21147506
13Viral myocarditis_Homo sapiens_hsa054162.01612279
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85806371
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.52834341
16Tuberculosis_Homo sapiens_hsa051521.52169388
17Histidine metabolism_Homo sapiens_hsa003401.43920921
18Hematopoietic cell lineage_Homo sapiens_hsa046401.42411502
19Ribosome_Homo sapiens_hsa030101.35088866
20Systemic lupus erythematosus_Homo sapiens_hsa053221.34556205
21Osteoclast differentiation_Homo sapiens_hsa043801.29053922
22Fanconi anemia pathway_Homo sapiens_hsa034601.20916766
23Toxoplasmosis_Homo sapiens_hsa051451.19454945
24B cell receptor signaling pathway_Homo sapiens_hsa046621.18452922
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17832119
26Oxidative phosphorylation_Homo sapiens_hsa001901.15519515
27Herpes simplex infection_Homo sapiens_hsa051681.14872557
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13575577
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13321207
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13014135
31Phagosome_Homo sapiens_hsa041451.12013787
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07842135
33RNA polymerase_Homo sapiens_hsa030201.04999674
34Parkinsons disease_Homo sapiens_hsa050121.03967856
35Malaria_Homo sapiens_hsa051441.00718136
36Influenza A_Homo sapiens_hsa051640.94554388
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90048091
38T cell receptor signaling pathway_Homo sapiens_hsa046600.88635523
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81862144
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.80772583
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79751642
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79045591
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78496502
44Alzheimers disease_Homo sapiens_hsa050100.77402343
45Sulfur metabolism_Homo sapiens_hsa009200.76807294
46beta-Alanine metabolism_Homo sapiens_hsa004100.72560419
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70256714
48Epstein-Barr virus infection_Homo sapiens_hsa051690.69856936
49Regulation of autophagy_Homo sapiens_hsa041400.68865159
50Chemokine signaling pathway_Homo sapiens_hsa040620.66320485
51Spliceosome_Homo sapiens_hsa030400.56976003
52TNF signaling pathway_Homo sapiens_hsa046680.56806659
53* HTLV-I infection_Homo sapiens_hsa051660.56296195
54Notch signaling pathway_Homo sapiens_hsa043300.56096573
55Huntingtons disease_Homo sapiens_hsa050160.55737795
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53160076
57Prolactin signaling pathway_Homo sapiens_hsa049170.51383664
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51255337
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50861527
60Legionellosis_Homo sapiens_hsa051340.50540650
61Dorso-ventral axis formation_Homo sapiens_hsa043200.49901435
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49362393
63Pertussis_Homo sapiens_hsa051330.49310567
64Linoleic acid metabolism_Homo sapiens_hsa005910.48916307
65Measles_Homo sapiens_hsa051620.48704768
66Base excision repair_Homo sapiens_hsa034100.47189476
67Platelet activation_Homo sapiens_hsa046110.46877294
68Basal transcription factors_Homo sapiens_hsa030220.46779447
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44496494
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43239618
71Shigellosis_Homo sapiens_hsa051310.42826747
72Apoptosis_Homo sapiens_hsa042100.42413091
73Arachidonic acid metabolism_Homo sapiens_hsa005900.41974561
74Ether lipid metabolism_Homo sapiens_hsa005650.40161238
75Ovarian steroidogenesis_Homo sapiens_hsa049130.38645892
76Hepatitis B_Homo sapiens_hsa051610.34416782
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34391268
78Proteasome_Homo sapiens_hsa030500.30382784
79Taste transduction_Homo sapiens_hsa047420.29805891
80African trypanosomiasis_Homo sapiens_hsa051430.27044609
81Purine metabolism_Homo sapiens_hsa002300.24087519
82RNA degradation_Homo sapiens_hsa030180.23693851
83Circadian rhythm_Homo sapiens_hsa047100.23174859
84Protein export_Homo sapiens_hsa030600.22684240
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.22666702
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21956804
87Type II diabetes mellitus_Homo sapiens_hsa049300.19180421
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.18436109
89Cardiac muscle contraction_Homo sapiens_hsa042600.18332989
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18132030
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17009599
92Pyrimidine metabolism_Homo sapiens_hsa002400.15523292
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12726732
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10373841
95Salmonella infection_Homo sapiens_hsa051320.10123510
96Olfactory transduction_Homo sapiens_hsa047400.09616341
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08674903
98Viral carcinogenesis_Homo sapiens_hsa052030.08037029
99FoxO signaling pathway_Homo sapiens_hsa040680.07943085
100Inositol phosphate metabolism_Homo sapiens_hsa005620.07544631

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