PTTG3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.85838925
2substrate-independent telencephalic tangential migration (GO:0021826)6.85838925
3ribosomal small subunit assembly (GO:0000028)6.28142992
4negative regulation of execution phase of apoptosis (GO:1900118)5.65890712
5DNA deamination (GO:0045006)5.02715873
6maturation of SSU-rRNA (GO:0030490)4.85122812
7cardiovascular system development (GO:0072358)4.70214105
8ribonucleoprotein complex disassembly (GO:0032988)4.66255048
9negative regulation of telomere maintenance (GO:0032205)4.61050051
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.57094274
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.29522256
12negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.20681976
13gonadal mesoderm development (GO:0007506)4.05024451
14protein neddylation (GO:0045116)3.97332340
15proteasome assembly (GO:0043248)3.95993066
16regulation of retinoic acid receptor signaling pathway (GO:0048385)3.94480848
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93769386
18ATP synthesis coupled proton transport (GO:0015986)3.93769386
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76497040
20protein-cofactor linkage (GO:0018065)3.68305093
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64641994
22piRNA metabolic process (GO:0034587)3.62488300
23ketone body metabolic process (GO:1902224)3.59822152
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58101616
25ribosomal small subunit biogenesis (GO:0042274)3.57538682
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55927201
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54267564
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54267564
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.53516421
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49303067
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49303067
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49303067
33regulation of telomere maintenance via telomerase (GO:0032210)3.49057526
34rRNA methylation (GO:0031167)3.44294565
35rRNA modification (GO:0000154)3.42445308
36cerebral cortex radially oriented cell migration (GO:0021799)3.41734404
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39019596
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.37459825
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37459825
40mannosylation (GO:0097502)3.33640083
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.32778517
42positive regulation of translational initiation (GO:0045948)3.26505752
43negative regulation of systemic arterial blood pressure (GO:0003085)3.25775406
44DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.24182071
45viral transcription (GO:0019083)3.22264297
46platelet dense granule organization (GO:0060155)3.22108679
47kinetochore assembly (GO:0051382)3.21280879
48translational termination (GO:0006415)3.19106890
49regulation of cilium movement (GO:0003352)3.18641214
50mitotic metaphase plate congression (GO:0007080)3.17880202
51protein localization to chromosome (GO:0034502)3.15093297
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14891578
53cotranslational protein targeting to membrane (GO:0006613)3.12785029
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12478000
55deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11509249
56kinetochore organization (GO:0051383)3.07898850
57dopamine transport (GO:0015872)3.06578128
58positive regulation of mitochondrial fission (GO:0090141)3.04466032
59spliceosomal complex assembly (GO:0000245)3.04404464
60anterograde synaptic vesicle transport (GO:0048490)3.04257482
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03909465
62transmission of nerve impulse (GO:0019226)3.02608438
63myoblast migration (GO:0051451)3.01565795
64protein targeting to ER (GO:0045047)3.01334641
65ventricular cardiac muscle cell development (GO:0055015)3.00258970
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98182875
67tongue development (GO:0043586)2.96191361
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94782284
69auditory receptor cell differentiation (GO:0042491)2.94140540
70translational initiation (GO:0006413)2.93412888
71translational elongation (GO:0006414)2.93308430
72protein complex biogenesis (GO:0070271)2.91961102
73negative regulation of potassium ion transmembrane transport (GO:1901380)2.91098771
74microtubule severing (GO:0051013)2.88799326
75negative regulation of cell cycle arrest (GO:0071157)2.86149677
76respiratory electron transport chain (GO:0022904)2.85949461
77regulation of execution phase of apoptosis (GO:1900117)2.85862386
78regulation of cellular amino acid metabolic process (GO:0006521)2.85722460
79establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85467679
80cellular ketone body metabolic process (GO:0046950)2.84695722
81electron transport chain (GO:0022900)2.83002393
82response to pheromone (GO:0019236)2.82797701
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82216097
84negative regulation of ligase activity (GO:0051352)2.82216097
85protein localization to endoplasmic reticulum (GO:0070972)2.80187270
86mitochondrial respiratory chain complex assembly (GO:0033108)2.80122609
87regulation of penile erection (GO:0060405)2.77946076
88peptidyl-histidine modification (GO:0018202)2.77062675
89purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.76868338
90DNA double-strand break processing (GO:0000729)2.76155348
91regulation of transcription from RNA polymerase I promoter (GO:0006356)2.76021888
92nucleotide transmembrane transport (GO:1901679)2.75031256
93translation (GO:0006412)2.74784419
94protein polyglutamylation (GO:0018095)2.71714039
95water-soluble vitamin biosynthetic process (GO:0042364)2.70133476
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64546752
97anterograde axon cargo transport (GO:0008089)2.61615945
98cellular protein complex disassembly (GO:0043624)2.61599118
99signal transduction in response to DNA damage (GO:0042770)2.61453823
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59748582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse7.41660646
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74098561
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71326971
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.45770936
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.23866948
6EZH2_22144423_ChIP-Seq_EOC_Human4.14547794
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.90136071
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.45153401
9VDR_22108803_ChIP-Seq_LS180_Human3.24369563
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79116529
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.55566138
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.51547954
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50882618
14IGF1R_20145208_ChIP-Seq_DFB_Human2.37940827
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28194931
16VDR_23849224_ChIP-Seq_CD4+_Human2.10626883
17ZNF274_21170338_ChIP-Seq_K562_Hela1.96979000
18EWS_26573619_Chip-Seq_HEK293_Human1.93280752
19FOXP3_21729870_ChIP-Seq_TREG_Human1.84468813
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.82066177
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80339487
22ELK1_19687146_ChIP-ChIP_HELA_Human1.79911649
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76228445
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75861741
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63602300
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57923493
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55948545
28FUS_26573619_Chip-Seq_HEK293_Human1.54267279
29MYC_18940864_ChIP-ChIP_HL60_Human1.53885877
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46773615
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46220653
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45839552
33E2F7_22180533_ChIP-Seq_HELA_Human1.45283759
34GABP_19822575_ChIP-Seq_HepG2_Human1.43293498
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40490245
36P300_19829295_ChIP-Seq_ESCs_Human1.38962457
37GATA1_22025678_ChIP-Seq_K562_Human1.36279632
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35422838
39ER_23166858_ChIP-Seq_MCF-7_Human1.33207037
40TP53_22573176_ChIP-Seq_HFKS_Human1.32303456
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31045194
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27202374
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24973676
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22607631
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15729066
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13368515
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13365771
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.12519465
49TTF2_22483619_ChIP-Seq_HELA_Human1.12258356
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.11256022
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11017718
52AR_21572438_ChIP-Seq_LNCaP_Human1.10297198
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07620287
54ELF5_23300383_ChIP-Seq_T47D_Human1.06534059
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05897699
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.05486420
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.02140213
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02140213
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02104286
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01273801
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.01031767
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00392854
63POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99864383
64KDM5A_27292631_Chip-Seq_BREAST_Human0.99227332
65HOXB7_26014856_ChIP-Seq_BT474_Human0.98776136
66MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98539007
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96364280
68FLI1_27457419_Chip-Seq_LIVER_Mouse0.95956445
69MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94323607
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94069937
71HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93099507
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92778912
73TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92596020
74NFE2_27457419_Chip-Seq_LIVER_Mouse0.91714650
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89827715
76PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89592048
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87466490
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87073269
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86546780
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86427479
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.86201136
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84588815
83XRN2_22483619_ChIP-Seq_HELA_Human0.84053254
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84032670
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83557469
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83509373
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.83432665
88* NANOG_19829295_ChIP-Seq_ESCs_Human0.81692702
89* SOX2_19829295_ChIP-Seq_ESCs_Human0.81692702
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.81038393
91AR_20517297_ChIP-Seq_VCAP_Human0.80471648
92ERG_20517297_ChIP-Seq_VCAP_Human0.79770143
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78898046
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78813125
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78449492
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77916083
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77695825
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77091955
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76163171
100NANOG_20526341_ChIP-Seq_ESCs_Human0.75454685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.68100721
2MP0010030_abnormal_orbit_morphology3.93447314
3MP0003136_yellow_coat_color3.57743400
4MP0009379_abnormal_foot_pigmentation2.94671409
5MP0002653_abnormal_ependyma_morphology2.85558551
6MP0002102_abnormal_ear_morphology2.74844045
7MP0000015_abnormal_ear_pigmentation2.70064023
8MP0004147_increased_porphyrin_level2.62712420
9MP0005645_abnormal_hypothalamus_physiol2.41633464
10MP0003646_muscle_fatigue2.38849030
11MP0005171_absent_coat_pigmentation2.38533536
12MP0000569_abnormal_digit_pigmentation2.28330613
13MP0002138_abnormal_hepatobiliary_system2.22881511
14MP0000372_irregular_coat_pigmentation2.18406933
15MP0001293_anophthalmia2.14655846
16MP0002277_abnormal_respiratory_mucosa2.14347670
17MP0005174_abnormal_tail_pigmentation2.10527795
18MP0001485_abnormal_pinna_reflex2.10246460
19MP0003693_abnormal_embryo_hatching2.09124467
20MP0000566_synostosis2.03955025
21MP0002736_abnormal_nociception_after2.03166211
22MP0002876_abnormal_thyroid_physiology1.95818971
23MP0008995_early_reproductive_senescence1.92292464
24MP0002095_abnormal_skin_pigmentation1.87968888
25MP0008058_abnormal_DNA_repair1.87513933
26MP0001968_abnormal_touch/_nociception1.78698483
27MP0003718_maternal_effect1.73714991
28MP0002837_dystrophic_cardiac_calcinosis1.71988892
29MP0003938_abnormal_ear_development1.67198358
30MP0004133_heterotaxia1.60449527
31MP0002163_abnormal_gland_morphology1.58756261
32MP0002938_white_spotting1.57400144
33MP0008789_abnormal_olfactory_epithelium1.56458495
34MP0002234_abnormal_pharynx_morphology1.54300758
35MP0003221_abnormal_cardiomyocyte_apopto1.54103798
36MP0000049_abnormal_middle_ear1.51878788
37MP0003878_abnormal_ear_physiology1.43208105
38MP0005377_hearing/vestibular/ear_phenot1.43208105
39MP0005408_hypopigmentation1.37841848
40MP0004142_abnormal_muscle_tone1.37434275
41MP0001986_abnormal_taste_sensitivity1.34792379
42MP0002233_abnormal_nose_morphology1.34569585
43MP0001984_abnormal_olfaction1.32908068
44MP0005084_abnormal_gallbladder_morpholo1.29532630
45MP0005075_abnormal_melanosome_morpholog1.28734517
46MP0002272_abnormal_nervous_system1.27821533
47MP0010094_abnormal_chromosome_stability1.26921059
48MP0003806_abnormal_nucleotide_metabolis1.26023664
49MP0002127_abnormal_cardiovascular_syste1.25293499
50MP0004145_abnormal_muscle_electrophysio1.14461267
51MP0000631_abnormal_neuroendocrine_gland1.13045630
52MP0008932_abnormal_embryonic_tissue1.11276172
53MP0000778_abnormal_nervous_system1.09982685
54MP0009046_muscle_twitch1.09615515
55MP0001286_abnormal_eye_development1.09535467
56MP0003122_maternal_imprinting1.07189278
57MP0000026_abnormal_inner_ear1.03845718
58MP0001348_abnormal_lacrimal_gland1.03350778
59MP0005394_taste/olfaction_phenotype1.02926514
60MP0005499_abnormal_olfactory_system1.02926514
61MP0001324_abnormal_eye_pigmentation1.01500010
62MP0005379_endocrine/exocrine_gland_phen1.00861665
63MP0001486_abnormal_startle_reflex0.98837161
64MP0004885_abnormal_endolymph0.97297471
65MP0005551_abnormal_eye_electrophysiolog0.95491766
66MP0003077_abnormal_cell_cycle0.93945492
67MP0008877_abnormal_DNA_methylation0.93659665
68MP0003186_abnormal_redox_activity0.93072295
69MP0006036_abnormal_mitochondrial_physio0.92770024
70MP0002282_abnormal_trachea_morphology0.91507764
71MP0002177_abnormal_outer_ear0.91322159
72MP0003880_abnormal_central_pattern0.90979223
73MP0004957_abnormal_blastocyst_morpholog0.90493732
74MP0001905_abnormal_dopamine_level0.90039721
75MP0002928_abnormal_bile_duct0.86643094
76MP0003567_abnormal_fetal_cardiomyocyte0.84182381
77MP0000639_abnormal_adrenal_gland0.83858902
78MP0005395_other_phenotype0.80754256
79MP0003385_abnormal_body_wall0.80667659
80MP0002735_abnormal_chemical_nociception0.80067044
81MP0002210_abnormal_sex_determination0.80046441
82MP0003755_abnormal_palate_morphology0.76006797
83MP0002166_altered_tumor_susceptibility0.73356938
84MP0003183_abnormal_peptide_metabolism0.69548390
85MP0005195_abnormal_posterior_eye0.69047824
86MP0008872_abnormal_physiological_respon0.67963676
87MP0002752_abnormal_somatic_nervous0.67760923
88MP0001529_abnormal_vocalization0.66385617
89MP0005266_abnormal_metabolism0.65129216
90MP0003937_abnormal_limbs/digits/tail_de0.64854416
91MP0005167_abnormal_blood-brain_barrier0.64476940
92MP0009053_abnormal_anal_canal0.63977860
93MP0003786_premature_aging0.63095547
94MP0001963_abnormal_hearing_physiology0.62619349
95MP0002822_catalepsy0.62016362
96MP0000685_abnormal_immune_system0.61109119
97MP0001929_abnormal_gametogenesis0.60754755
98MP0008775_abnormal_heart_ventricle0.60286223
99MP0003195_calcinosis0.60127868
100MP0004811_abnormal_neuron_physiology0.58603346

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.82407315
2Reticulocytopenia (HP:0001896)4.48235320
3Abnormality of cells of the erythroid lineage (HP:0012130)3.85738177
4Aplasia/Hypoplasia of the sacrum (HP:0008517)3.82145669
5Septo-optic dysplasia (HP:0100842)3.79374791
6Tubulointerstitial nephritis (HP:0001970)3.71721293
7Stenosis of the external auditory canal (HP:0000402)3.68239982
8Absent thumb (HP:0009777)3.52848004
9Abnormality of the labia minora (HP:0012880)3.36938033
10Colon cancer (HP:0003003)3.24727353
11Hip dysplasia (HP:0001385)3.23064328
12Supernumerary spleens (HP:0009799)3.17459053
13Increased CSF lactate (HP:0002490)3.13172785
14Congenital stationary night blindness (HP:0007642)3.05144195
15Cerebral hypomyelination (HP:0006808)3.04378653
16Flat capital femoral epiphysis (HP:0003370)2.98405288
17Acute necrotizing encephalopathy (HP:0006965)2.94438449
18Anterior segment dysgenesis (HP:0007700)2.90764473
19Absent septum pellucidum (HP:0001331)2.83904996
20Abnormal number of erythroid precursors (HP:0012131)2.78884149
21Mitochondrial inheritance (HP:0001427)2.78094527
22Tubular atrophy (HP:0000092)2.73920070
23Abnormal mitochondria in muscle tissue (HP:0008316)2.64268196
24Abnormality of glycolysis (HP:0004366)2.64162488
25Maternal diabetes (HP:0009800)2.61868738
26Molar tooth sign on MRI (HP:0002419)2.60495105
27Abnormality of midbrain morphology (HP:0002418)2.60495105
28Optic nerve hypoplasia (HP:0000609)2.56764191
29Hepatic necrosis (HP:0002605)2.47628849
30Renal Fanconi syndrome (HP:0001994)2.46459615
31Myokymia (HP:0002411)2.41446068
32Pancreatic cysts (HP:0001737)2.40048466
33Nephronophthisis (HP:0000090)2.39105922
34B lymphocytopenia (HP:0010976)2.38597297
35Neoplasm of the adrenal cortex (HP:0100641)2.37788082
36Failure to thrive in infancy (HP:0001531)2.36286172
37Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34356937
38Progressive macrocephaly (HP:0004481)2.34177352
39Abnormality of the septum pellucidum (HP:0007375)2.33737280
40Oligodactyly (HP:0012165)2.32561046
41Synostosis involving the elbow (HP:0003938)2.31672389
42Humeroradial synostosis (HP:0003041)2.31672389
43Small hand (HP:0200055)2.31634688
44Concave nail (HP:0001598)2.29868273
45Increased serum lactate (HP:0002151)2.28575123
46Hepatocellular necrosis (HP:0001404)2.26476340
47Sclerocornea (HP:0000647)2.25837426
48Acute encephalopathy (HP:0006846)2.25429429
49Thyroid-stimulating hormone excess (HP:0002925)2.22511960
50Focal motor seizures (HP:0011153)2.20790227
51Retinal dysplasia (HP:0007973)2.18615651
52Chromsome breakage (HP:0040012)2.15336309
53Hypoplasia of the ulna (HP:0003022)2.15228569
54Hypoplasia of the fovea (HP:0007750)2.14349122
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.14349122
563-Methylglutaconic aciduria (HP:0003535)2.13705528
57Gonadotropin excess (HP:0000837)2.11615648
58Aplasia/Hypoplasia of the ulna (HP:0006495)2.09821684
59Abnormality of the diencephalon (HP:0010662)2.08467067
60IgG deficiency (HP:0004315)2.08001575
61Symphalangism affecting the phalanges of the hand (HP:0009773)2.07069985
62Missing ribs (HP:0000921)2.06033251
63Abnormality of B cell number (HP:0010975)2.05469037
64Poor head control (HP:0002421)2.05358712
65Adrenal hypoplasia (HP:0000835)2.03765745
66Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.03639171
67Abnormality of the renal collecting system (HP:0004742)2.01286005
68Premature ovarian failure (HP:0008209)2.00032194
69Carpal bone hypoplasia (HP:0001498)1.99775958
70Increased IgM level (HP:0003496)1.99691630
71CNS hypomyelination (HP:0003429)1.97131340
72Pallor (HP:0000980)1.96230798
73Abnormality of the renal medulla (HP:0100957)1.94007737
74Macrocytic anemia (HP:0001972)1.93854812
75Partial duplication of thumb phalanx (HP:0009944)1.92621064
76Rhabdomyosarcoma (HP:0002859)1.91440129
77Abnormal lung lobation (HP:0002101)1.90379949
78Generalized aminoaciduria (HP:0002909)1.87852918
79Esophageal atresia (HP:0002032)1.87163878
80Increased hepatocellular lipid droplets (HP:0006565)1.86572446
81Duplicated collecting system (HP:0000081)1.85889623
82Ectopic kidney (HP:0000086)1.85111697
83Overriding aorta (HP:0002623)1.80272290
84Growth hormone deficiency (HP:0000824)1.79880218
85Lipid accumulation in hepatocytes (HP:0006561)1.79754369
86Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79180854
87Lissencephaly (HP:0001339)1.79109558
88Polyphagia (HP:0002591)1.78078334
89Respiratory difficulties (HP:0002880)1.77958680
90Increased serum pyruvate (HP:0003542)1.76494783
91Hemivertebrae (HP:0002937)1.76293351
92Oligodactyly (hands) (HP:0001180)1.75028605
93Iris hypopigmentation (HP:0007730)1.73036474
94CNS demyelination (HP:0007305)1.72610182
95Type II lissencephaly (HP:0007260)1.71760204
96Medial flaring of the eyebrow (HP:0010747)1.71471522
97Asplenia (HP:0001746)1.71255908
98Forearm undergrowth (HP:0009821)1.68116101
99Abnormality of the fovea (HP:0000493)1.67864300
100Atonic seizures (HP:0010819)1.67638458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41581336
2MAP3K93.67159255
3CCNB13.63742580
4MAP3K123.38681993
5MAP4K23.31406919
6STK393.14285977
7VRK23.06318664
8WNK42.65468436
9CASK2.18237484
10PDK22.16228067
11INSRR2.01984535
12STK161.69253656
13LRRK21.66930602
14EIF2AK11.54540642
15NEK11.46445407
16MAP3K131.46038801
17PAK31.43565913
18TAF11.40752231
19TSSK61.38696055
20SRPK11.34939013
21EIF2AK31.29686392
22BRAF1.25554686
23MST41.23129849
24PLK21.22741510
25LIMK11.19243018
26PLK31.18752114
27DAPK31.18592576
28MKNK11.18249396
29KSR11.14958455
30KDR1.14101408
31TRIM281.12037108
32NUAK11.09115273
33GRK11.07149617
34BRSK21.04146184
35WEE11.03532181
36PLK41.02525260
37ATR1.01353299
38MAPK131.00511599
39TESK20.98633562
40ARAF0.94991780
41PINK10.93999294
42VRK10.91549168
43MKNK20.89827542
44MAPKAPK50.87190027
45OXSR10.86847587
46KSR20.86631337
47TEC0.86360352
48EIF2AK20.82652835
49PLK10.81449305
50ADRBK20.79786989
51TGFBR20.79666381
52NEK20.79202780
53STK38L0.78246442
54FRK0.76875090
55DAPK10.76693065
56PAK60.75804496
57DYRK20.74858359
58BRSK10.74788471
59MARK30.72013163
60WNK30.67658850
61CSNK1E0.66682759
62TTK0.66424691
63TLK10.65979038
64AURKB0.64918267
65PAK20.63706045
66TIE10.63364005
67CDK80.63044550
68AKT30.62444820
69PRKCG0.60746322
70CSNK1G30.59961669
71CSNK1G10.58336698
72RPS6KA40.56849560
73FGFR20.55073303
74PIM10.54316759
75CSNK1G20.53248230
76MAP3K50.52894758
77CHEK20.51296366
78CSNK1A1L0.50739642
79BCKDK0.50083177
80CDK70.49729666
81CDK180.48528928
82NEK90.48299259
83PIK3CA0.47937657
84PRKCQ0.47602620
85PRKAA20.47471071
86CHEK10.45126497
87PKN10.44246505
88CDK150.44156263
89CSNK2A10.44068243
90GRK50.43374048
91ABL20.43126284
92CSNK2A20.42815303
93RAF10.41924293
94ZAK0.41688133
95CDK140.39537661
96CDK11A0.39138880
97ATM0.39069941
98CLK10.38936893
99DYRK1A0.38431115
100STK30.37985060

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.11618550
2Ribosome_Homo sapiens_hsa030103.93899191
3Protein export_Homo sapiens_hsa030603.84689276
4Oxidative phosphorylation_Homo sapiens_hsa001903.51847943
5Parkinsons disease_Homo sapiens_hsa050123.26710933
6RNA polymerase_Homo sapiens_hsa030203.08501028
7Homologous recombination_Homo sapiens_hsa034402.87847814
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.79151710
9Huntingtons disease_Homo sapiens_hsa050162.48263724
10Alzheimers disease_Homo sapiens_hsa050102.28891850
11Basal transcription factors_Homo sapiens_hsa030222.07100902
12RNA degradation_Homo sapiens_hsa030182.05395099
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04124950
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91280771
15Fanconi anemia pathway_Homo sapiens_hsa034601.86533869
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83600341
17Butanoate metabolism_Homo sapiens_hsa006501.74154338
18Sulfur relay system_Homo sapiens_hsa041221.71900307
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64888387
20One carbon pool by folate_Homo sapiens_hsa006701.63519872
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63176954
22Spliceosome_Homo sapiens_hsa030401.57357262
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.47618589
24Propanoate metabolism_Homo sapiens_hsa006401.44488222
25RNA transport_Homo sapiens_hsa030131.32861646
26Pyruvate metabolism_Homo sapiens_hsa006201.29210203
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28063357
28Sulfur metabolism_Homo sapiens_hsa009201.19308206
29Pyrimidine metabolism_Homo sapiens_hsa002401.17609138
30Collecting duct acid secretion_Homo sapiens_hsa049661.15100081
31Cell cycle_Homo sapiens_hsa041101.14331482
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13029548
33Primary immunodeficiency_Homo sapiens_hsa053401.12410283
34Non-homologous end-joining_Homo sapiens_hsa034501.10303235
35Cardiac muscle contraction_Homo sapiens_hsa042601.05937556
36Linoleic acid metabolism_Homo sapiens_hsa005911.05928712
37Folate biosynthesis_Homo sapiens_hsa007901.03505271
38Mismatch repair_Homo sapiens_hsa034300.97512065
39beta-Alanine metabolism_Homo sapiens_hsa004100.96799952
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95607074
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92738436
42Oocyte meiosis_Homo sapiens_hsa041140.91744729
43Nucleotide excision repair_Homo sapiens_hsa034200.90411413
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87456995
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.86062965
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86056882
47Dorso-ventral axis formation_Homo sapiens_hsa043200.86048079
48p53 signaling pathway_Homo sapiens_hsa041150.77749974
49Tryptophan metabolism_Homo sapiens_hsa003800.77302722
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75779123
51Purine metabolism_Homo sapiens_hsa002300.73751167
52Taste transduction_Homo sapiens_hsa047420.73199288
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.71749999
54DNA replication_Homo sapiens_hsa030300.71115567
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70932058
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.69345689
57Base excision repair_Homo sapiens_hsa034100.68917318
58N-Glycan biosynthesis_Homo sapiens_hsa005100.67509700
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66380844
60Fat digestion and absorption_Homo sapiens_hsa049750.66310380
61Epstein-Barr virus infection_Homo sapiens_hsa051690.64944345
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59616690
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58490348
64Metabolic pathways_Homo sapiens_hsa011000.58430341
65Ether lipid metabolism_Homo sapiens_hsa005650.58189420
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54759351
67Arachidonic acid metabolism_Homo sapiens_hsa005900.53756948
68Nicotine addiction_Homo sapiens_hsa050330.48477385
69Notch signaling pathway_Homo sapiens_hsa043300.46774039
70Asthma_Homo sapiens_hsa053100.46176012
71Fatty acid degradation_Homo sapiens_hsa000710.45993641
72Systemic lupus erythematosus_Homo sapiens_hsa053220.45975825
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45781232
74Peroxisome_Homo sapiens_hsa041460.44480638
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.44432578
76Phototransduction_Homo sapiens_hsa047440.43814047
77Olfactory transduction_Homo sapiens_hsa047400.43302387
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42031400
79Hedgehog signaling pathway_Homo sapiens_hsa043400.40184543
80Alcoholism_Homo sapiens_hsa050340.35546034
81mRNA surveillance pathway_Homo sapiens_hsa030150.30418039
82Chemical carcinogenesis_Homo sapiens_hsa052040.27556162
83Arginine and proline metabolism_Homo sapiens_hsa003300.25584827
84Autoimmune thyroid disease_Homo sapiens_hsa053200.24460273
85Fatty acid elongation_Homo sapiens_hsa000620.23688985
86TGF-beta signaling pathway_Homo sapiens_hsa043500.23653045
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23090796
88Allograft rejection_Homo sapiens_hsa053300.21658523
89Steroid biosynthesis_Homo sapiens_hsa001000.20927922
90Caffeine metabolism_Homo sapiens_hsa002320.19819220
91Amphetamine addiction_Homo sapiens_hsa050310.19462831
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19393314
93Serotonergic synapse_Homo sapiens_hsa047260.17898831
94Retinol metabolism_Homo sapiens_hsa008300.15075030
95Antigen processing and presentation_Homo sapiens_hsa046120.14919614
96Starch and sucrose metabolism_Homo sapiens_hsa005000.14815012
97Rheumatoid arthritis_Homo sapiens_hsa053230.14552212
98Tyrosine metabolism_Homo sapiens_hsa003500.14039628
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12408168
100Bladder cancer_Homo sapiens_hsa052190.12374565

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