PTTG4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)9.87603958
2regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)9.60813179
3regulation of podosome assembly (GO:0071801)9.21068309
4regulation of vitamin D biosynthetic process (GO:0060556)8.72234052
5positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)8.71412459
6negative regulation of interleukin-17 production (GO:0032700)8.63179384
7regulation of MHC class II biosynthetic process (GO:0045346)8.49938142
8negative regulation of metanephros development (GO:0072217)8.19166262
9regulation of isotype switching to IgG isotypes (GO:0048302)8.09834119
10positive regulation of chemokine biosynthetic process (GO:0045080)6.95806763
11negative regulation of neurological system process (GO:0031645)6.83980420
12regulation of vitamin metabolic process (GO:0030656)6.78744962
13regulation of smooth muscle cell apoptotic process (GO:0034391)6.31014482
14regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)6.20019972
15positive regulation of muscle cell apoptotic process (GO:0010661)6.10662098
16defense response to protozoan (GO:0042832)5.52928475
17regulation of interleukin-6 biosynthetic process (GO:0045408)5.52337607
18positive regulation of isotype switching (GO:0045830)5.44497234
19positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.21353656
20positive regulation of osteoclast differentiation (GO:0045672)5.15911383
21regulation of chemokine biosynthetic process (GO:0045073)5.11683384
22alpha-beta T cell differentiation involved in immune response (GO:0002293)5.10552647
23alpha-beta T cell activation involved in immune response (GO:0002287)5.10552647
24T cell differentiation involved in immune response (GO:0002292)5.10552647
25positive regulation of steroid biosynthetic process (GO:0010893)5.10077192
26regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.01088376
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.98293610
28positive regulation of DNA recombination (GO:0045911)4.96032252
29regulation of interleukin-17 production (GO:0032660)4.76658100
30negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.70876344
31modulation of growth of symbiont involved in interaction with host (GO:0044144)4.70876344
32regulation of growth of symbiont in host (GO:0044126)4.70876344
33negative regulation of growth of symbiont in host (GO:0044130)4.70876344
34positive regulation of interleukin-1 beta secretion (GO:0050718)4.68009056
35myeloid dendritic cell differentiation (GO:0043011)4.58605545
36response to protozoan (GO:0001562)4.54268108
37positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.53047206
38regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.47011937
39negative regulation of kidney development (GO:0090185)4.44567434
40monoubiquitinated protein deubiquitination (GO:0035520)4.38543127
41positive regulation of interleukin-1 secretion (GO:0050716)4.37447169
42positive regulation of phosphatase activity (GO:0010922)4.31613050
43regulation of interleukin-1 beta secretion (GO:0050706)4.28088690
44regulation of cytokine production involved in inflammatory response (GO:1900015)4.24404994
45regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.22162625
46leukocyte apoptotic process (GO:0071887)4.21685774
47positive regulation of alcohol biosynthetic process (GO:1902932)4.14939695
48myeloid dendritic cell activation (GO:0001773)4.01474576
49regulation of protein kinase A signaling (GO:0010738)3.86488040
50positive regulation of interleukin-12 production (GO:0032735)3.84564703
51regulation of interleukin-1 secretion (GO:0050704)3.76406334
52alpha-beta T cell differentiation (GO:0046632)3.73052765
53regulation of isotype switching (GO:0045191)3.71590472
54positive regulation of organelle assembly (GO:1902117)3.61528843
55regulation of response to interferon-gamma (GO:0060330)3.52932658
56regulation of membrane protein ectodomain proteolysis (GO:0051043)3.51917355
57positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.51552897
58regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.50351524
59protein import into nucleus, translocation (GO:0000060)3.45260708
60C4-dicarboxylate transport (GO:0015740)3.32373766
61regulation of metanephros development (GO:0072215)3.31434358
62positive regulation of monooxygenase activity (GO:0032770)3.26179529
63positive regulation of interleukin-1 beta production (GO:0032731)3.25886091
64alpha-beta T cell activation (GO:0046631)3.16631660
65macrophage activation (GO:0042116)3.10311610
66cellular response to interleukin-15 (GO:0071350)3.08513749
67regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.05749320
68positive regulation of immunoglobulin mediated immune response (GO:0002891)3.03017778
69positive regulation of B cell mediated immunity (GO:0002714)3.03017778
70positive regulation of interleukin-1 production (GO:0032732)2.96456696
71protein-cofactor linkage (GO:0018065)2.94817325
72retinal cone cell development (GO:0046549)2.88719455
73positive regulation of JAK-STAT cascade (GO:0046427)2.87795721
74regulation of regulatory T cell differentiation (GO:0045589)2.84852569
75regulation of the force of heart contraction (GO:0002026)2.81056815
76negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.79441390
77response to pheromone (GO:0019236)2.75228805
78dopamine transport (GO:0015872)2.75053632
79regulation of interleukin-12 production (GO:0032655)2.72619233
80DNA double-strand break processing (GO:0000729)2.69094244
81regulation of clathrin-mediated endocytosis (GO:2000369)2.65351858
82positive regulation of immunoglobulin production (GO:0002639)2.63562572
83ether lipid metabolic process (GO:0046485)2.59748982
84fucose catabolic process (GO:0019317)2.58631902
85L-fucose metabolic process (GO:0042354)2.58631902
86L-fucose catabolic process (GO:0042355)2.58631902
87cornea development in camera-type eye (GO:0061303)2.58583061
88embryonic placenta development (GO:0001892)2.58470637
89T cell activation involved in immune response (GO:0002286)2.58292844
90dendritic cell differentiation (GO:0097028)2.54369347
91neurotransmitter uptake (GO:0001504)2.54048877
92positive regulation of myeloid leukocyte differentiation (GO:0002763)2.53369468
93positive regulation of steroid metabolic process (GO:0045940)2.51767012
94regulation of macrophage derived foam cell differentiation (GO:0010743)2.48871425
95retinal rod cell development (GO:0046548)2.47913439
96behavioral response to pain (GO:0048266)2.47715101
97response to interleukin-15 (GO:0070672)2.45550245
98positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)13.4480577
99regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)13.4480577
100regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:000333911.4146991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse5.00809771
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.92853478
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.38042337
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.18599641
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08102489
6GBX2_23144817_ChIP-Seq_PC3_Human2.86534794
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.81818860
8IGF1R_20145208_ChIP-Seq_DFB_Human2.60761059
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46102974
10ZNF274_21170338_ChIP-Seq_K562_Hela2.45419413
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43126532
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21077859
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.18792658
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18521346
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.18521346
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03316990
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99521287
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96368566
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.95639305
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.94560574
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90034028
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88488305
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78446276
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76795154
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76671170
26ELK1_19687146_ChIP-ChIP_HELA_Human1.74951267
27SMAD4_21799915_ChIP-Seq_A2780_Human1.72367887
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72062391
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70052388
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68631962
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.64393122
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.61153950
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54598044
34FLI1_21867929_ChIP-Seq_TH2_Mouse1.54402732
35P300_19829295_ChIP-Seq_ESCs_Human1.54050413
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.51437853
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.50016029
38TCF4_23295773_ChIP-Seq_U87_Human1.49620302
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.46993764
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.44599785
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42627301
42CBP_20019798_ChIP-Seq_JUKART_Human1.42627301
43EWS_26573619_Chip-Seq_HEK293_Human1.41014528
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.40649841
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36878245
46VDR_23849224_ChIP-Seq_CD4+_Human1.35422927
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35165025
48BCAT_22108803_ChIP-Seq_LS180_Human1.35100904
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33236959
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30622241
51FUS_26573619_Chip-Seq_HEK293_Human1.30505527
52STAT3_23295773_ChIP-Seq_U87_Human1.29489596
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28454108
54OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27781429
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27377583
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26946339
57AR_21572438_ChIP-Seq_LNCaP_Human1.26244404
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24966120
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23388648
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22478789
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.20325674
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19012034
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.18334000
64STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17817155
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14812000
66LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14599696
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12683633
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12374652
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.11643675
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11596836
71RUNX2_22187159_ChIP-Seq_PCA_Human1.10416610
72RUNX_20019798_ChIP-Seq_JUKART_Human1.08279444
73P300_18555785_Chip-Seq_ESCs_Mouse1.07567063
74VDR_24787735_ChIP-Seq_THP-1_Human1.07052419
75ER_23166858_ChIP-Seq_MCF-7_Human1.06719764
76GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.06166541
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06122441
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03801802
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03792010
80MYB_26560356_Chip-Seq_TH2_Human1.03173364
81TCF4_22108803_ChIP-Seq_LS180_Human1.02944872
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.02047055
83TP53_16413492_ChIP-PET_HCT116_Human1.01565224
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.00631389
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98748889
86TP53_22573176_ChIP-Seq_HFKS_Human0.98012136
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97356662
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96809126
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96395554
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95307251
91AR_25329375_ChIP-Seq_VCAP_Human0.92965381
92LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92608794
93JUN_21703547_ChIP-Seq_K562_Human0.90396550
94STAT1_17558387_ChIP-Seq_HELA_Human0.89994040
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.89468418
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89181134
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.88492702
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.88435068
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88336230
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87941987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation7.51547229
2MP0001835_abnormal_antigen_presentation6.09620666
3MP0004782_abnormal_surfactant_physiolog4.94002205
4MP0010307_abnormal_tumor_latency4.40948019
5MP0001958_emphysema4.13400435
6MP0005671_abnormal_response_to3.51639686
7MP0008877_abnormal_DNA_methylation2.87516912
8MP0002405_respiratory_system_inflammati2.81207059
9MP0009333_abnormal_splenocyte_physiolog2.68041314
10MP0003186_abnormal_redox_activity2.64211268
11MP0003950_abnormal_plasma_membrane2.40319648
12MP0009785_altered_susceptibility_to2.33817851
13MP0003436_decreased_susceptibility_to2.21290796
14MP0005000_abnormal_immune_tolerance2.02145196
15MP0002148_abnormal_hypersensitivity_rea1.94623878
16MP0004142_abnormal_muscle_tone1.86278763
17MP0004885_abnormal_endolymph1.78523820
18MP0008057_abnormal_DNA_replication1.76889198
19MP0009780_abnormal_chondrocyte_physiolo1.75464137
20MP0000569_abnormal_digit_pigmentation1.70425275
21MP0002933_joint_inflammation1.61284674
22MP0002102_abnormal_ear_morphology1.58036992
23MP0004859_abnormal_synaptic_plasticity1.56138816
24MP0002254_reproductive_system_inflammat1.55633966
25MP0004145_abnormal_muscle_electrophysio1.52141045
26MP0005387_immune_system_phenotype1.51878670
27MP0001790_abnormal_immune_system1.51878670
28MP0001529_abnormal_vocalization1.51403136
29MP0001800_abnormal_humoral_immune1.46004746
30MP0005551_abnormal_eye_electrophysiolog1.44640031
31MP0001663_abnormal_digestive_system1.38577334
32MP0001881_abnormal_mammary_gland1.37190933
33MP0003724_increased_susceptibility_to1.31520058
34MP0001764_abnormal_homeostasis1.20898258
35MP0003221_abnormal_cardiomyocyte_apopto1.20774805
36MP0008569_lethality_at_weaning1.18936437
37MP0009765_abnormal_xenobiotic_induced1.18915428
38MP0002396_abnormal_hematopoietic_system1.15286619
39MP0004742_abnormal_vestibular_system1.08706612
40MP0010155_abnormal_intestine_physiology1.06194568
41MP0002736_abnormal_nociception_after1.03472182
42MP0000372_irregular_coat_pigmentation1.02851587
43MP0005501_abnormal_skin_physiology1.02479274
44MP0005423_abnormal_somatic_nervous1.02032601
45MP0005253_abnormal_eye_physiology0.98751864
46MP0009745_abnormal_behavioral_response0.96650077
47MP0001968_abnormal_touch/_nociception0.96294412
48MP0008058_abnormal_DNA_repair0.96086424
49MP0000383_abnormal_hair_follicle0.92302745
50MP0003787_abnormal_imprinting0.92038325
51MP0003448_altered_tumor_morphology0.91941671
52MP0010094_abnormal_chromosome_stability0.89118292
53MP0001485_abnormal_pinna_reflex0.83749673
54MP0005310_abnormal_salivary_gland0.83336893
55MP0000685_abnormal_immune_system0.81185447
56MP0002723_abnormal_immune_serum0.80945793
57MP0002722_abnormal_immune_system0.78841256
58MP0000689_abnormal_spleen_morphology0.77981176
59MP0005381_digestive/alimentary_phenotyp0.77477352
60MP0009697_abnormal_copulation0.76289504
61MP0003567_abnormal_fetal_cardiomyocyte0.76147484
62MP0001533_abnormal_skeleton_physiology0.75432711
63MP0005166_decreased_susceptibility_to0.74078995
64MP0003656_abnormal_erythrocyte_physiolo0.73579770
65MP0002419_abnormal_innate_immunity0.72880834
66MP0005076_abnormal_cell_differentiation0.72631268
67MP0008873_increased_physiological_sensi0.71844062
68MP0003195_calcinosis0.70631063
69MP0006035_abnormal_mitochondrial_morpho0.70352202
70MP0003763_abnormal_thymus_physiology0.67737138
71MP0002420_abnormal_adaptive_immunity0.67506352
72MP0010678_abnormal_skin_adnexa0.66521800
73MP0001853_heart_inflammation0.65627507
74MP0001661_extended_life_span0.64387600
75MP0001819_abnormal_immune_cell0.63973980
76MP0004484_altered_response_of0.63069637
77MP0001845_abnormal_inflammatory_respons0.62886744
78MP0008770_decreased_survivor_rate0.62356353
79MP0000703_abnormal_thymus_morphology0.61533461
80MP0005171_absent_coat_pigmentation0.59275313
81MP0003045_fibrosis0.58014258
82MP0002693_abnormal_pancreas_physiology0.56967921
83MP0001324_abnormal_eye_pigmentation0.56767516
84MP0003880_abnormal_central_pattern0.56685978
85MP0005319_abnormal_enzyme/_coenzyme0.56551649
86MP0003635_abnormal_synaptic_transmissio0.55923012
87MP0003091_abnormal_cell_migration0.55715807
88MP0000015_abnormal_ear_pigmentation0.54098867
89MP0002452_abnormal_antigen_presenting0.53558351
90MP0005025_abnormal_response_to0.53510565
91MP0000631_abnormal_neuroendocrine_gland0.52972927
92MP0001119_abnormal_female_reproductive0.52183915
93MP0005084_abnormal_gallbladder_morpholo0.52163252
94MP0006036_abnormal_mitochondrial_physio0.51337607
95MP0002136_abnormal_kidney_physiology0.50955837
96MP0002019_abnormal_tumor_incidence0.50822798
97MP0006072_abnormal_retinal_apoptosis0.50724639
98MP0002063_abnormal_learning/memory/cond0.49612831
99MP0004197_abnormal_fetal_growth/weight/0.49245055
100MP0003936_abnormal_reproductive_system0.47900534

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.11092639
2IgA deficiency (HP:0002720)4.37680342
3Cutaneous melanoma (HP:0012056)4.04888628
4Abnormality of the labia minora (HP:0012880)3.92459658
5Abnormal hair whorl (HP:0010721)3.50668829
6Hyperventilation (HP:0002883)3.38379937
7Carpal bone hypoplasia (HP:0001498)3.37637682
8Hypoplastic pelvis (HP:0008839)3.34157570
9Attenuation of retinal blood vessels (HP:0007843)3.26781748
10T lymphocytopenia (HP:0005403)3.26126084
11Atonic seizures (HP:0010819)3.21824633
12Abnormality of T cell number (HP:0011839)3.11512480
13Delayed epiphyseal ossification (HP:0002663)2.96518724
14Progressive inability to walk (HP:0002505)2.93251208
15Increased density of long bones (HP:0006392)2.91515549
16IgG deficiency (HP:0004315)2.87987381
17Abnormality of the metopic suture (HP:0005556)2.86630503
18Difficulty running (HP:0009046)2.80183442
19Hepatoblastoma (HP:0002884)2.75439626
20Poor head control (HP:0002421)2.74926738
21Recurrent fungal infections (HP:0002841)2.70227374
22Hypothermia (HP:0002045)2.68846194
23Hypoplastic labia majora (HP:0000059)2.64589965
24Entropion (HP:0000621)2.63120232
25Decreased lacrimation (HP:0000633)2.62685342
26Pelvic girdle muscle weakness (HP:0003749)2.45171826
27Inability to walk (HP:0002540)2.44352228
28Abnormality of the labia majora (HP:0012881)2.44018475
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43861409
30Abnormality of the pons (HP:0007361)2.42744506
31Abnormality of macular pigmentation (HP:0008002)2.42611073
32Impaired vibration sensation in the lower limbs (HP:0002166)2.41394534
33Limb dystonia (HP:0002451)2.39830543
34Abnormality of T cells (HP:0002843)2.36869708
35Abnormality of the hip-girdle musculature (HP:0001445)2.34284303
36Abnormality of the musculature of the pelvis (HP:0001469)2.34284303
37Type 2 muscle fiber atrophy (HP:0003554)2.33163214
38Increased IgM level (HP:0003496)2.24970795
39Cholecystitis (HP:0001082)2.23280487
40Abnormal gallbladder physiology (HP:0012438)2.23280487
41Keratoconjunctivitis (HP:0001096)2.21951898
42Colon cancer (HP:0003003)2.21264904
43Pancreatic cysts (HP:0001737)2.18952009
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.18573967
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18573967
46Chronic diarrhea (HP:0002028)2.16780832
47Prominent metopic ridge (HP:0005487)2.15709259
48Long clavicles (HP:0000890)2.11074914
49Biconcave vertebral bodies (HP:0004586)2.09274762
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.09241636
51IgM deficiency (HP:0002850)2.09096926
52Scotoma (HP:0000575)2.04764246
53Muscle fiber atrophy (HP:0100295)2.00349563
54Hypoplasia of the pons (HP:0012110)2.00240407
55Opisthotonus (HP:0002179)2.00038506
56Autoamputation (HP:0001218)1.99933835
57Chromsome breakage (HP:0040012)1.98312280
58Enlarged epiphyses (HP:0010580)1.97795657
59Tubulointerstitial fibrosis (HP:0005576)1.95539661
60Broad-based gait (HP:0002136)1.95345901
61Gaze-evoked nystagmus (HP:0000640)1.95001464
62Chronic mucocutaneous candidiasis (HP:0002728)1.93840632
63Recurrent cutaneous fungal infections (HP:0011370)1.93840632
64Abnormality of chromosome stability (HP:0003220)1.92239247
65Small epiphyses (HP:0010585)1.92204996
66Xerostomia (HP:0000217)1.90683772
67Cystic hygroma (HP:0000476)1.89881913
68Urinary bladder sphincter dysfunction (HP:0002839)1.89261055
69Stomach cancer (HP:0012126)1.86457494
70Cholelithiasis (HP:0001081)1.85198418
71Abnormality of B cell number (HP:0010975)1.82512453
72Optic disc pallor (HP:0000543)1.82480091
73Hypoplastic female external genitalia (HP:0012815)1.81588054
74Keratitis (HP:0000491)1.81346543
75Constricted visual fields (HP:0001133)1.80494281
76Joint swelling (HP:0001386)1.79169599
77Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79104835
78Facial hemangioma (HP:0000329)1.77988075
79Labial hypoplasia (HP:0000066)1.77557646
80Glucose intolerance (HP:0000833)1.76567169
81Irregular vertebral endplates (HP:0003301)1.76413460
82Abnormality of the corticospinal tract (HP:0002492)1.76006322
83Basal cell carcinoma (HP:0002671)1.75933746
84Focal seizures (HP:0007359)1.75699772
85Abnormality of the septum pellucidum (HP:0007375)1.75446294
86Febrile seizures (HP:0002373)1.75351275
87Abnormal gallbladder morphology (HP:0012437)1.75000400
88Ureteral obstruction (HP:0006000)1.74112572
89Hemiplegia (HP:0002301)1.73730076
90Muscular dystrophy (HP:0003560)1.73219713
91Severe visual impairment (HP:0001141)1.73078437
92Limb hypertonia (HP:0002509)1.72258444
93Hypoplastic nipples (HP:0002557)1.71176539
94Shoulder girdle muscle weakness (HP:0003547)1.71115909
95Fair hair (HP:0002286)1.70209676
96Abnormality of T cell physiology (HP:0011840)1.68707090
97Alacrima (HP:0000522)1.68628445
98Urinary urgency (HP:0000012)1.68343191
99Eosinophilia (HP:0001880)1.67486963
100Metaphyseal irregularity (HP:0003025)1.67484616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.40220068
2NME14.59490099
3MAP3K64.56718448
4MAP3K44.21144057
5MAP2K73.70122941
6EIF2AK33.47281449
7BMPR1B2.62701595
8PIK3CG2.52785165
9MAP3K52.31217055
10MAP2K42.14140603
11WNK32.06694942
12FRK1.91688146
13CAMKK21.85797777
14EIF2AK11.73168535
15AKT31.70035207
16CASK1.68093549
17ERBB31.52944204
18PLK41.51640493
19BRSK21.50877960
20BRD41.49849480
21ACVR1B1.43844809
22MARK11.41578199
23PDK21.35725885
24GRK71.28749939
25WNK11.21973492
26TNK21.21370543
27PINK11.16488181
28MAP3K71.10989922
29PKN21.06871151
30MAP3K121.01454474
31MST41.00054127
32PKN10.96345751
33CLK10.96225474
34MAPK130.93563511
35MKNK20.89665661
36EIF2AK20.88260408
37TSSK60.87776488
38PAK30.82523221
39JAK20.81960682
40FGFR20.81042310
41MAP4K10.80606975
42SRPK10.79111154
43DYRK20.77586515
44FLT30.76311867
45IRAK10.74787541
46NUAK10.72656123
47ADRBK20.69819289
48STK380.66937180
49NEK60.64318167
50PLK20.63123943
51OXSR10.61959931
52FER0.61572237
53TAOK30.60802966
54MAP3K140.59931359
55FGFR10.59569425
56VRK10.59221492
57VRK20.58611483
58ADRBK10.57145339
59CAMK40.55336107
60TRIM280.52080686
61RET0.51169228
62GRK10.50669667
63PRKCQ0.49971902
64CAMK10.49710940
65BLK0.49476344
66CAMK1D0.48796747
67PLK30.47952742
68NTRK20.47529379
69TLK10.47328969
70BRSK10.45281091
71PDGFRB0.44533720
72CAMK1G0.43287782
73ZAK0.43162103
74PIK3CA0.40408095
75PAK60.38904546
76DYRK1A0.37313852
77MAP2K60.37234388
78ATM0.36944349
79MARK20.36849922
80SGK20.36048455
81SYK0.35211383
82WNK40.35198603
83TEC0.33149446
84UHMK10.32538777
85STK100.31940878
86TGFBR10.31481250
87YES10.30625047
88PTK2B0.28408508
89HCK0.27294462
90TNIK0.27222571
91GRK60.26404213
92CAMKK10.25143470
93GRK50.22825709
94NLK0.22331557
95CDC70.20780885
96ZAP700.18339770
97CDK50.18179098
98STK110.17336635
99PRKG10.17156696
100JAK10.17137568

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.93652106
2Regulation of autophagy_Homo sapiens_hsa041404.19949107
3African trypanosomiasis_Homo sapiens_hsa051433.34637199
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.15915123
5Allograft rejection_Homo sapiens_hsa053303.10956421
6Rheumatoid arthritis_Homo sapiens_hsa053233.02196787
7Malaria_Homo sapiens_hsa051442.64404637
8T cell receptor signaling pathway_Homo sapiens_hsa046602.63286473
9Non-homologous end-joining_Homo sapiens_hsa034502.49994107
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.34785046
11Jak-STAT signaling pathway_Homo sapiens_hsa046302.32082906
12Salmonella infection_Homo sapiens_hsa051322.10953805
13Graft-versus-host disease_Homo sapiens_hsa053321.99840334
14Protein export_Homo sapiens_hsa030601.92993882
15Phototransduction_Homo sapiens_hsa047441.91679068
16Type I diabetes mellitus_Homo sapiens_hsa049401.85229711
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78548683
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.72310246
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65579077
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63849256
21Fanconi anemia pathway_Homo sapiens_hsa034601.61218435
22Fatty acid biosynthesis_Homo sapiens_hsa000611.55171424
23Amoebiasis_Homo sapiens_hsa051461.48317537
24TNF signaling pathway_Homo sapiens_hsa046681.35705432
25Measles_Homo sapiens_hsa051621.20225536
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17336750
27Hematopoietic cell lineage_Homo sapiens_hsa046401.17053521
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15834337
29Primary immunodeficiency_Homo sapiens_hsa053401.11837089
30Nicotine addiction_Homo sapiens_hsa050331.10317090
31Homologous recombination_Homo sapiens_hsa034401.02756612
32Linoleic acid metabolism_Homo sapiens_hsa005911.02480914
33Colorectal cancer_Homo sapiens_hsa052100.98954495
34Taste transduction_Homo sapiens_hsa047420.96637931
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96136733
36Vitamin B6 metabolism_Homo sapiens_hsa007500.96052676
37Butanoate metabolism_Homo sapiens_hsa006500.93698709
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91179811
39Basal transcription factors_Homo sapiens_hsa030220.87254294
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86140485
41HIF-1 signaling pathway_Homo sapiens_hsa040660.84003688
42Antigen processing and presentation_Homo sapiens_hsa046120.83911148
43TGF-beta signaling pathway_Homo sapiens_hsa043500.82774635
44One carbon pool by folate_Homo sapiens_hsa006700.81730165
45Toxoplasmosis_Homo sapiens_hsa051450.81062391
46Steroid biosynthesis_Homo sapiens_hsa001000.78244757
47Tuberculosis_Homo sapiens_hsa051520.77271639
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76917631
49Leishmaniasis_Homo sapiens_hsa051400.75258811
50RNA polymerase_Homo sapiens_hsa030200.70802805
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69242968
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67316975
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65485696
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63796900
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63055230
56Type II diabetes mellitus_Homo sapiens_hsa049300.61777178
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60636723
58Ether lipid metabolism_Homo sapiens_hsa005650.60182568
59Osteoclast differentiation_Homo sapiens_hsa043800.58796794
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58066139
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57755368
62Morphine addiction_Homo sapiens_hsa050320.56862886
63Fructose and mannose metabolism_Homo sapiens_hsa000510.53858582
64Circadian rhythm_Homo sapiens_hsa047100.52067397
65Prolactin signaling pathway_Homo sapiens_hsa049170.51335366
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50567825
67Inositol phosphate metabolism_Homo sapiens_hsa005620.48679256
68Epstein-Barr virus infection_Homo sapiens_hsa051690.47399262
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.46388111
70Hedgehog signaling pathway_Homo sapiens_hsa043400.45799751
71Glutamatergic synapse_Homo sapiens_hsa047240.38809495
72Systemic lupus erythematosus_Homo sapiens_hsa053220.38400077
73Glycerolipid metabolism_Homo sapiens_hsa005610.38000698
74Autoimmune thyroid disease_Homo sapiens_hsa053200.37263648
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36573363
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35637054
77Influenza A_Homo sapiens_hsa051640.35024937
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34484644
79Ras signaling pathway_Homo sapiens_hsa040140.34077054
80Choline metabolism in cancer_Homo sapiens_hsa052310.31692931
81Wnt signaling pathway_Homo sapiens_hsa043100.30600506
82Viral myocarditis_Homo sapiens_hsa054160.30550037
83Dorso-ventral axis formation_Homo sapiens_hsa043200.30170981
84Pyrimidine metabolism_Homo sapiens_hsa002400.29611171
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29047520
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28132693
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25482786
88Dopaminergic synapse_Homo sapiens_hsa047280.25062345
89Herpes simplex infection_Homo sapiens_hsa051680.22162696
90RNA transport_Homo sapiens_hsa030130.20593102
91Serotonergic synapse_Homo sapiens_hsa047260.20339285
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.19020122
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16459081
94GABAergic synapse_Homo sapiens_hsa047270.15540159
95Chemokine signaling pathway_Homo sapiens_hsa040620.15300193
96Pancreatic cancer_Homo sapiens_hsa052120.14586772
97RNA degradation_Homo sapiens_hsa030180.14530168
98Cholinergic synapse_Homo sapiens_hsa047250.14108182
99Apoptosis_Homo sapiens_hsa042100.13297109
100FoxO signaling pathway_Homo sapiens_hsa040680.13262034

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