PTX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.04132940
2collagen fibril organization (GO:0030199)5.82216864
3wound healing, spreading of epidermal cells (GO:0035313)5.28212329
4virion attachment to host cell (GO:0019062)4.67509535
5adhesion of symbiont to host cell (GO:0044650)4.67509535
6negative regulation of nitric oxide biosynthetic process (GO:0045019)4.55392855
7regulation of vitamin D biosynthetic process (GO:0060556)4.49054940
8regulation of T-helper 1 cell differentiation (GO:0045625)4.48270109
9cellular response to interferon-alpha (GO:0035457)4.42646465
10positive regulation of chemokine biosynthetic process (GO:0045080)4.40540933
11skin morphogenesis (GO:0043589)4.37859866
12endodermal cell differentiation (GO:0035987)4.36004026
13bone trabecula formation (GO:0060346)4.30352687
14sequestering of extracellular ligand from receptor (GO:0035581)4.21773963
15regulation of chronic inflammatory response (GO:0002676)4.11461890
16regulation of cytokine secretion involved in immune response (GO:0002739)4.09215493
17branching involved in labyrinthine layer morphogenesis (GO:0060670)4.08178846
18positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.08113147
19adhesion of symbiont to host (GO:0044406)4.04276076
20positive regulation of natural killer cell differentiation (GO:0032825)4.04009495
21wound healing, spreading of cells (GO:0044319)3.94746270
22regulation of vitamin metabolic process (GO:0030656)3.94525225
23regulation of mononuclear cell migration (GO:0071675)3.82831943
24positive regulation of endothelial cell apoptotic process (GO:2000353)3.75701258
25collagen metabolic process (GO:0032963)3.73849223
26negative regulation of interleukin-12 production (GO:0032695)3.73465409
27chondrocyte proliferation (GO:0035988)3.72843415
28collagen catabolic process (GO:0030574)3.71009240
29cell adhesion mediated by integrin (GO:0033627)3.70229624
30positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.52220894
31regulation of chemokine biosynthetic process (GO:0045073)3.49875840
32* regulation of nitric oxide biosynthetic process (GO:0045428)3.48699523
33apoptotic cell clearance (GO:0043277)3.46334053
34multicellular organismal macromolecule metabolic process (GO:0044259)3.45246659
35eosinophil chemotaxis (GO:0048245)3.43109566
36mesenchymal-epithelial cell signaling (GO:0060638)3.43008877
37regulation of chemokine-mediated signaling pathway (GO:0070099)3.41693831
38peptidyl-proline hydroxylation (GO:0019511)3.40989374
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38798664
40regulation of fever generation (GO:0031620)3.38076434
41multicellular organismal catabolic process (GO:0044243)3.35591104
42positive regulation of heat generation (GO:0031652)3.34910855
43regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.29009305
44neutrophil activation involved in immune response (GO:0002283)3.28312200
45extracellular matrix assembly (GO:0085029)3.27203597
46chronic inflammatory response (GO:0002544)3.26914279
47dermatan sulfate biosynthetic process (GO:0030208)3.26536849
48multicellular organismal metabolic process (GO:0044236)3.25951713
49axon extension involved in axon guidance (GO:0048846)3.24770711
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.24770711
51regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.23068722
52cell migration involved in heart development (GO:0060973)3.21821922
53regulation of monocyte chemotaxis (GO:0090025)3.21516538
54regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.17196413
55epoxygenase P450 pathway (GO:0019373)3.17057333
56positive regulation of monocyte chemotaxis (GO:0090026)3.16992634
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16811936
58blood vessel maturation (GO:0001955)3.16104519
59response to interferon-alpha (GO:0035455)3.15696742
60type I interferon signaling pathway (GO:0060337)3.15618131
61cellular response to type I interferon (GO:0071357)3.15618131
62endothelial cell morphogenesis (GO:0001886)3.10535497
63positive regulation of astrocyte differentiation (GO:0048711)3.10523292
64response to type I interferon (GO:0034340)3.09966130
65tooth mineralization (GO:0034505)3.09942236
66* positive regulation of nitric oxide biosynthetic process (GO:0045429)3.07989060
67fibril organization (GO:0097435)3.07942957
68extracellular matrix disassembly (GO:0022617)3.05532169
69positive regulation vascular endothelial growth factor production (GO:0010575)3.03838663
70eosinophil migration (GO:0072677)3.01844854
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.01427646
72response to peptidoglycan (GO:0032494)3.01169338
73hydrogen peroxide biosynthetic process (GO:0050665)3.00887680
74extracellular fibril organization (GO:0043206)2.99027757
75positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.98832971
76regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98364337
77positive regulation of blood vessel endothelial cell migration (GO:0043536)2.98125347
78hyaluronan catabolic process (GO:0030214)2.95940545
79cellular response to vitamin (GO:0071295)2.95882369
80dermatan sulfate metabolic process (GO:0030205)2.94590175
81cellular response to amino acid stimulus (GO:0071230)2.94088510
82regulation of plasminogen activation (GO:0010755)2.93179139
83omega-hydroxylase P450 pathway (GO:0097267)2.92239297
84regulation of membrane protein ectodomain proteolysis (GO:0051043)2.92218239
85positive regulation by symbiont of host defense response (GO:0052509)2.90650889
86modulation by symbiont of host defense response (GO:0052031)2.90650889
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90650889
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90650889
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.90650889
90modulation by symbiont of host immune response (GO:0052553)2.90650889
91regulation of immunoglobulin secretion (GO:0051023)2.90643756
92protein localization to endosome (GO:0036010)2.90352043
93positive regulation of interferon-alpha production (GO:0032727)2.89766859
94positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.89149236
95regulation of vascular endothelial growth factor production (GO:0010574)2.89067177
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.89034673
97regulation of T-helper 2 cell differentiation (GO:0045628)2.88565354
98cellular response to vitamin D (GO:0071305)2.87477733
99keratan sulfate catabolic process (GO:0042340)2.87335722
100regulation of heat generation (GO:0031650)2.86734404
101regulation of heterotypic cell-cell adhesion (GO:0034114)2.85966691
102detection of molecule of bacterial origin (GO:0032490)2.85403652
103negative regulation of biomineral tissue development (GO:0070168)2.84979473
104production of molecular mediator involved in inflammatory response (GO:0002532)2.82619292
105removal of superoxide radicals (GO:0019430)2.78733641
106cellular response to superoxide (GO:0071451)2.78733641
107cellular response to oxygen radical (GO:0071450)2.78733641
108positive regulation of extracellular matrix organization (GO:1903055)2.76548912
109negative regulation of lipid storage (GO:0010888)2.75277015
110respiratory burst (GO:0045730)2.73902214
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73360025
112monocyte chemotaxis (GO:0002548)2.73068850
113negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.72870196
114positive regulation of chemokine production (GO:0032722)2.71924243
115regulation of interferon-alpha production (GO:0032647)2.71889937
116retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71868859
117superoxide anion generation (GO:0042554)2.71574010
118response to muramyl dipeptide (GO:0032495)2.68863323
119response to magnesium ion (GO:0032026)2.68593078
120decidualization (GO:0046697)2.68420923
121negative regulation of homotypic cell-cell adhesion (GO:0034111)2.68131970
122negative regulation of smooth muscle cell migration (GO:0014912)2.67283906
123regulation of lymphocyte chemotaxis (GO:1901623)2.67159033
124substrate-dependent cell migration (GO:0006929)2.66900207
125negative regulation of monooxygenase activity (GO:0032769)2.65401400
126barbed-end actin filament capping (GO:0051016)2.64926693
127regulation of endothelial cell apoptotic process (GO:2000351)2.64556988
128regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63390173
129positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.62964389
130cellular response to lipopolysaccharide (GO:0071222)2.62788044
131activation of MAPKKK activity (GO:0000185)2.62271783
132regulation of extracellular matrix disassembly (GO:0010715)2.59948278
133positive regulation of acute inflammatory response (GO:0002675)2.58843121
134type B pancreatic cell proliferation (GO:0044342)2.58636198
135reactive oxygen species biosynthetic process (GO:1903409)2.57901486
136vascular endothelial growth factor signaling pathway (GO:0038084)2.56775688
137negative regulation of fatty acid transport (GO:2000192)2.55024491
138metanephric mesenchyme development (GO:0072075)2.54976538
139kidney mesenchyme development (GO:0072074)2.54886142
140regulation of podosome assembly (GO:0071801)2.54350857
141negative regulation of platelet activation (GO:0010544)2.54025522
142protein hydroxylation (GO:0018126)2.53012950
143negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.52849593
144positive regulation of interleukin-6 production (GO:0032755)2.52498226
145positive regulation of fibroblast migration (GO:0010763)2.52486028
146NIK/NF-kappaB signaling (GO:0038061)2.52482320
147positive regulation of p38MAPK cascade (GO:1900745)2.51320276
148positive regulation of smooth muscle cell migration (GO:0014911)2.51310203
149regulation of macrophage cytokine production (GO:0010935)2.51286703
150positive regulation of leukocyte chemotaxis (GO:0002690)2.51236770
151negative regulation of cytokine secretion (GO:0050710)2.50101668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.85275323
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.92799665
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.56247470
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.21758130
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.05614195
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.85077600
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.43568323
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.27638589
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.13846901
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08963237
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.05724557
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92708446
13* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.85812612
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.82476001
15* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.80837439
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72614950
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.58753367
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.57519981
19* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.54172078
20* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.54172078
21CJUN_26792858_Chip-Seq_BT549_Human2.48393733
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36195117
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.29637715
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.25455813
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23225287
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22401846
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08144871
28CLOCK_20551151_ChIP-Seq_293T_Human2.04477205
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00864954
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00722314
31* BRD4_25478319_ChIP-Seq_HGPS_Human1.83758729
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82884521
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72188085
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69956751
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66762852
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66582222
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64835147
38JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58812504
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58649918
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58649918
41TP53_18474530_ChIP-ChIP_U2OS_Human1.53801021
42JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52546561
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.50465370
44SOX2_20726797_ChIP-Seq_SW620_Human1.50149728
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49665884
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.47771063
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45433783
48ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.43705332
49VDR_24787735_ChIP-Seq_THP-1_Human1.43111996
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37606421
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37483058
52SMC1_22415368_ChIP-Seq_MEFs_Mouse1.36463786
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33393501
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30991713
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30937357
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29345993
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25179096
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24444906
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22221255
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19912100
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.17693099
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15157661
63* EP300_21415370_ChIP-Seq_HL-1_Mouse1.14871466
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.13810448
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12438931
66TP53_16413492_ChIP-PET_HCT116_Human1.09511036
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09472198
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09307269
69VDR_24763502_ChIP-Seq_THP-1_Human1.07391944
70TP53_22127205_ChIP-Seq_IMR90_Human1.04755015
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03352248
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02975484
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02800193
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02293389
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.01748812
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.01748812
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00821315
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00537435
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99905186
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99681387
81TP53_20018659_ChIP-ChIP_R1E_Mouse0.99614033
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99066634
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99066634
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99066634
85* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98920134
86* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96859931
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95734706
88NFI_21473784_ChIP-Seq_ESCs_Mouse0.92920438
89SA1_22415368_ChIP-Seq_MEFs_Mouse0.92735039
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92152354
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.91772047
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91127009
93* EED_16625203_ChIP-ChIP_MESCs_Mouse0.90363343
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.90202522
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89285710
96* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89181525
97EGR1_19032775_ChIP-ChIP_M12_Human0.88494504
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87970205
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85449559
100PU_27001747_Chip-Seq_BMDM_Mouse0.85433323
101KDM2B_26808549_Chip-Seq_K562_Human0.84803468
102ATF3_27146783_Chip-Seq_COLON_Human0.83965307
103* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83041174
104TP53_23651856_ChIP-Seq_MEFs_Mouse0.82632371
105* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81853173
106* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81561446
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80437539
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80040013
109* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79120769
110TP63_23658742_ChIP-Seq_EP156T_Human0.78172746
111LXR_22292898_ChIP-Seq_THP-1_Human0.77157279
112* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76982338
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76516094
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75685733
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74108337
116* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.72523527
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72343391
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69919492
119RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69919492
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.69817350
121KLF5_25053715_ChIP-Seq_YYC3_Human0.69632522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.68855824
2MP0005275_abnormal_skin_tensile5.44513726
3MP0005503_abnormal_tendon_morphology5.33950382
4MP0003705_abnormal_hypodermis_morpholog4.72096859
5MP0003279_aneurysm4.43944118
6MP0001958_emphysema3.66327894
7MP0009384_cardiac_valve_regurgitation2.89713641
8MP0003724_increased_susceptibility_to2.53182852
9MP0006054_spinal_hemorrhage2.44732584
10MP0005257_abnormal_intraocular_pressure2.40277524
11MP0003436_decreased_susceptibility_to2.17988252
12MP0003950_abnormal_plasma_membrane2.08169360
13MP0001533_abnormal_skeleton_physiology2.02131800
14MP0002295_abnormal_pulmonary_circulatio2.01773119
15MP0001542_abnormal_bone_strength1.97052198
16MP0002933_joint_inflammation1.96667024
17MP0005508_abnormal_skeleton_morphology1.85389172
18MP0005390_skeleton_phenotype1.83101565
19MP0010352_gastrointestinal_tract_polyps1.80114228
20MP0006082_CNS_inflammation1.78575662
21MP0002148_abnormal_hypersensitivity_rea1.73168733
22MP0002060_abnormal_skin_morphology1.70015809
23MP0003303_peritoneal_inflammation1.69223871
24MP0002998_abnormal_bone_remodeling1.69214340
25MP0002332_abnormal_exercise_endurance1.68729576
26MP0005171_absent_coat_pigmentation1.64218253
27MP0005023_abnormal_wound_healing1.63587945
28MP0009785_altered_susceptibility_to1.61796048
29MP0004272_abnormal_basement_membrane1.55937010
30MP0004858_abnormal_nervous_system1.51016491
31MP0005000_abnormal_immune_tolerance1.48560326
32MP0003448_altered_tumor_morphology1.46304663
33MP0003566_abnormal_cell_adhesion1.45413729
34MP0003091_abnormal_cell_migration1.43220047
35MP0002254_reproductive_system_inflammat1.39007851
36MP0009840_abnormal_foam_cell1.38830659
37MP0005623_abnormal_meninges_morphology1.37337440
38MP0001835_abnormal_antigen_presentation1.37047975
39* MP0002419_abnormal_innate_immunity1.34950183
40MP0001243_abnormal_dermal_layer1.34917807
41MP0002108_abnormal_muscle_morphology1.34404348
42MP0003941_abnormal_skin_development1.25265278
43MP0003385_abnormal_body_wall1.18007779
44MP0000767_abnormal_smooth_muscle1.17237306
45MP0009764_decreased_sensitivity_to1.13433094
46MP0002282_abnormal_trachea_morphology1.12136535
47MP0002896_abnormal_bone_mineralization1.11995893
48MP0005165_increased_susceptibility_to1.11274351
49MP0005164_abnormal_response_to1.10532338
50MP0000858_altered_metastatic_potential1.09177251
51MP0005076_abnormal_cell_differentiation1.08495738
52MP0000343_altered_response_to1.06960621
53MP0000604_amyloidosis1.05807495
54MP0009250_abnormal_appendicular_skeleto1.05794708
55MP0002115_abnormal_skeleton_extremities1.05104246
56MP0001299_abnormal_eye_distance/1.05103462
57MP0005451_abnormal_body_composition1.05035543
58MP0010386_abnormal_urinary_bladder1.04473868
59MP0004947_skin_inflammation1.03775657
60MP0004134_abnormal_chest_morphology1.02708493
61* MP0005025_abnormal_response_to0.99830606
62MP0009278_abnormal_bone_marrow0.98545367
63MP0003795_abnormal_bone_structure0.97163013
64MP0000163_abnormal_cartilage_morphology0.94102584
65MP0004510_myositis0.93871832
66MP0000733_abnormal_muscle_development0.90682442
67MP0000685_abnormal_immune_system0.90329598
68MP0002168_other_aberrant_phenotype0.88968773
69MP0001853_heart_inflammation0.88634671
70* MP0002452_abnormal_antigen_presenting0.87785366
71MP0002113_abnormal_skeleton_development0.87127548
72MP0002877_abnormal_melanocyte_morpholog0.86372808
73MP0003075_altered_response_to0.85502391
74MP0001545_abnormal_hematopoietic_system0.82609009
75MP0005397_hematopoietic_system_phenotyp0.82609009
76MP0008469_abnormal_protein_level0.82083733
77MP0008004_abnormal_stomach_pH0.81651899
78MP0003191_abnormal_cellular_cholesterol0.81625927
79MP0002133_abnormal_respiratory_system0.76920634
80MP0005388_respiratory_system_phenotype0.76920634
81MP0005197_abnormal_uvea_morphology0.76109050
82MP0010155_abnormal_intestine_physiology0.75156560
83MP0001348_abnormal_lacrimal_gland0.74324897
84MP0001790_abnormal_immune_system0.74231566
85MP0005387_immune_system_phenotype0.74231566
86MP0002006_tumorigenesis0.73729941
87MP0004233_abnormal_muscle_weight0.71372856
88MP0002723_abnormal_immune_serum0.71156233
89MP0009763_increased_sensitivity_to0.69172368
90MP0005167_abnormal_blood-brain_barrier0.68932031
91* MP0002405_respiratory_system_inflammati0.68642302
92MP0003045_fibrosis0.68398059
93MP0005058_abnormal_lysosome_morphology0.66200756
94MP0000750_abnormal_muscle_regeneration0.65729298
95MP0000013_abnormal_adipose_tissue0.64863213
96MP0001915_intracranial_hemorrhage0.64385421
97MP0003300_gastrointestinal_ulcer0.64197485
98MP0001845_abnormal_inflammatory_respons0.63268803
99MP0005166_decreased_susceptibility_to0.63013987
100MP0000249_abnormal_blood_vessel0.61907200
101MP0009053_abnormal_anal_canal0.61718396
102MP0001849_ear_inflammation0.61474243
103MP0002932_abnormal_joint_morphology0.60928748
104MP0005464_abnormal_platelet_physiology0.60783310
105MP0001851_eye_inflammation0.60698412
106MP0005595_abnormal_vascular_smooth0.60215387
107MP0010030_abnormal_orbit_morphology0.60004761
108MP0000751_myopathy0.58952370
109MP0010368_abnormal_lymphatic_system0.58765157
110MP0001614_abnormal_blood_vessel0.58763409
111MP0003828_pulmonary_edema0.57586425
112MP0001879_abnormal_lymphatic_vessel0.57175782
113MP0005671_abnormal_response_to0.56993839
114MP0002128_abnormal_blood_circulation0.56522760
115MP0004808_abnormal_hematopoietic_stem0.56377280
116MP0000428_abnormal_craniofacial_morphol0.56212295
117* MP0001819_abnormal_immune_cell0.54318231
118MP0003453_abnormal_keratinocyte_physiol0.53944443
119MP0001177_atelectasis0.53235269
120MP0004883_abnormal_blood_vessel0.52715933

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.10399217
2Premature rupture of membranes (HP:0001788)8.41868063
3Peritonitis (HP:0002586)6.75502079
4Soft skin (HP:0000977)5.28041529
5Aortic dissection (HP:0002647)5.06373749
6Vertebral compression fractures (HP:0002953)4.82731441
7Dilatation of the ascending aorta (HP:0005111)4.37049740
8Atrophic scars (HP:0001075)4.36654959
9Bladder diverticulum (HP:0000015)4.31230690
10Aortic aneurysm (HP:0004942)4.19524911
11Genu recurvatum (HP:0002816)4.19066303
12Shallow orbits (HP:0000586)4.18250755
13Abnormality of dentin (HP:0010299)4.16707150
14Biconcave vertebral bodies (HP:0004586)4.13472063
15Ankle contracture (HP:0006466)4.04983578
16Abnormality of glycolipid metabolism (HP:0010969)3.99205159
17Abnormality of liposaccharide metabolism (HP:0010968)3.99205159
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.99205159
19Wormian bones (HP:0002645)3.73340898
20Fragile skin (HP:0001030)3.67226670
21Neonatal short-limb short stature (HP:0008921)3.61405897
22Vascular tortuosity (HP:0004948)3.54209670
23Wrist flexion contracture (HP:0001239)3.45650596
24Follicular hyperkeratosis (HP:0007502)3.44711792
25Broad metatarsal (HP:0001783)3.40841510
26Blue sclerae (HP:0000592)3.38803289
27Arterial tortuosity (HP:0005116)3.22822982
28Mitral valve prolapse (HP:0001634)3.21135042
29Eczematoid dermatitis (HP:0000976)3.19962548
30Overgrowth (HP:0001548)3.15722850
31Abnormal delivery (HP:0001787)3.06729875
32Hyperextensible skin (HP:0000974)3.04481044
33Abnormality of the peritoneum (HP:0002585)3.03723282
34Cervical subluxation (HP:0003308)3.03210891
35Bowel diverticulosis (HP:0005222)2.97242327
36Cerebral aneurysm (HP:0004944)2.97215919
37Dysostosis multiplex (HP:0000943)2.96449997
38Infantile muscular hypotonia (HP:0008947)2.90684382
39Nuclear cataract (HP:0100018)2.84094513
40Coxa vara (HP:0002812)2.83146830
41Ectopia lentis (HP:0001083)2.80366686
42Type 1 muscle fiber predominance (HP:0003803)2.79762789
43Orchitis (HP:0100796)2.74899608
44Spondylolisthesis (HP:0003302)2.63272554
45Recurrent gram-negative bacterial infections (HP:0005420)2.62757118
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59620303
47Abnormality of polysaccharide metabolism (HP:0011012)2.59620303
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59620303
49Breech presentation (HP:0001623)2.59089829
50Systemic lupus erythematosus (HP:0002725)2.58079174
51Mucopolysacchariduria (HP:0008155)2.57919002
52Urinary glycosaminoglycan excretion (HP:0003541)2.57919002
53Elbow flexion contracture (HP:0002987)2.57409187
54Elevated erythrocyte sedimentation rate (HP:0003565)2.55063756
55Hematochezia (HP:0002573)2.53930719
56Osteoarthritis (HP:0002758)2.51802944
57Spinal rigidity (HP:0003306)2.51058344
58Slender build (HP:0001533)2.48521417
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.47788973
60Osteolytic defects of the hand bones (HP:0009699)2.47788973
61Optic neuritis (HP:0100653)2.47700598
62Retrobulbar optic neuritis (HP:0100654)2.47700598
63Abnormality of the acetabulum (HP:0003170)2.46730882
64Aortic valve stenosis (HP:0001650)2.45692112
65Broad ribs (HP:0000885)2.43910718
66Ovoid vertebral bodies (HP:0003300)2.43012995
67Mitral stenosis (HP:0001718)2.40533858
68Recurrent abscess formation (HP:0002722)2.40416343
69Joint stiffness (HP:0001387)2.38921075
70Thin bony cortex (HP:0002753)2.38229680
71Increased variability in muscle fiber diameter (HP:0003557)2.33497192
72Tibial bowing (HP:0002982)2.32617384
73Aneurysm (HP:0002617)2.25486698
74Recurrent bacterial skin infections (HP:0005406)2.25478768
75Vacuolated lymphocytes (HP:0001922)2.24687449
76Nonimmune hydrops fetalis (HP:0001790)2.22061109
77Myositis (HP:0100614)2.20966079
78Joint laxity (HP:0001388)2.19822406
79Flared iliac wings (HP:0002869)2.19343207
80Femoral bowing (HP:0002980)2.13354207
81Beaking of vertebral bodies (HP:0004568)2.12661689
82Autoimmune thrombocytopenia (HP:0001973)2.10186572
83Coronal craniosynostosis (HP:0004440)2.08231594
84Limited elbow extension (HP:0001377)2.06258665
85Deviation of the hallux (HP:0010051)2.05688781
86Spinal cord lesions (HP:0100561)2.05066216
87Syringomyelia (HP:0003396)2.05066216
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04756032
89Loss of speech (HP:0002371)2.02097026
90Mild short stature (HP:0003502)2.01587514
91Hallux valgus (HP:0001822)2.00649376
92Wide anterior fontanel (HP:0000260)1.99278726
93Round ear (HP:0100830)1.97376880
94Mediastinal lymphadenopathy (HP:0100721)1.94934149
95Abnormality of skeletal muscle fiber size (HP:0012084)1.93461186
96Ulnar bowing (HP:0003031)1.92880382
97Increased connective tissue (HP:0009025)1.91060733
98Hypoplasia of the iris (HP:0007676)1.90391469
99Decreased skull ossification (HP:0004331)1.90322861
100Venous abnormality (HP:0002624)1.90043532
101Camptodactyly of toe (HP:0001836)1.89540732
102Platyspondyly (HP:0000926)1.88424157
103Mildly elevated creatine phosphokinase (HP:0008180)1.88027463
104Emphysema (HP:0002097)1.87011461
105Venous insufficiency (HP:0005293)1.85419409
106Abnormality of skull ossification (HP:0002703)1.84832522
107Abnormality of the anterior chamber (HP:0000593)1.84364078
108Delayed closure of the anterior fontanelle (HP:0001476)1.83272636
109Abnormality of the pericardium (HP:0001697)1.82842396
110Striae distensae (HP:0001065)1.82390478
111Poor head control (HP:0002421)1.82223149
112Asymmetric septal hypertrophy (HP:0001670)1.81673900
113Thoracolumbar scoliosis (HP:0002944)1.81585330
114Conjunctival telangiectasia (HP:0000524)1.81504301
115Cellulitis (HP:0100658)1.81288429
116Interstitial pulmonary disease (HP:0006530)1.81215830
117Congenital glaucoma (HP:0001087)1.80993224
118Myocardial infarction (HP:0001658)1.80333079
119Generalized amyotrophy (HP:0003700)1.78634587
120Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.78176236
121Hypoventilation (HP:0002791)1.77998287
122Mitral regurgitation (HP:0001653)1.77263245
123Absent frontal sinuses (HP:0002688)1.77011477
124Inguinal hernia (HP:0000023)1.75681211
125Flexion contracture of toe (HP:0005830)1.75610996
126Joint contractures involving the joints of the feet (HP:0100492)1.75610996
127Abnormality of macrophages (HP:0004311)1.73558291
128Achilles tendon contracture (HP:0001771)1.73510189
129Protruding ear (HP:0000411)1.71631333
130Basal ganglia calcification (HP:0002135)1.71208050
131Short nail (HP:0001799)1.71008120
132Abnormality of complement system (HP:0005339)1.69630417
133Cupped ribs (HP:0000887)1.69315468
134Aortic regurgitation (HP:0001659)1.69248974
135Radial bowing (HP:0002986)1.68808070
136Mesomelia (HP:0003027)1.68779608
137Morphological abnormality of the middle ear (HP:0008609)1.67799302
138Osteopenia (HP:0000938)1.66710504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.77820143
2DDR24.39990908
3ERN13.78004023
4RIPK43.06489982
5LATS23.05292077
6TTN2.87884380
7MAP3K142.79558253
8GRK72.77648076
9BLK2.76326589
10BMX2.68231154
11NME22.41239589
12TBK12.40697732
13PDGFRA2.38576920
14PIM22.36263132
15TRIB32.16833079
16JAK32.01331127
17MAP3K31.91665182
18EPHA31.88069899
19MST1R1.87747460
20TYK21.87400570
21PRPF4B1.87214870
22CDC42BPA1.84373343
23SIK11.80627549
24NEK91.77625751
25IKBKB1.72177072
26JAK11.70136229
27ABL21.69884681
28RPS6KA41.55217528
29EPHB21.49563742
30MYLK1.49444794
31ADRBK21.46720487
32TRPM71.46495618
33MOS1.33669139
34MAP3K131.32173860
35KIT1.30729081
36CLK11.29845228
37TIE11.25865287
38MAP2K31.23753164
39MET1.16292734
40ARAF1.10541554
41ERBB31.08837398
42IKBKE1.07621655
43PAK61.06566276
44PLK21.02351191
45STK30.97728363
46TESK10.93995329
47PDGFRB0.93353327
48ERBB40.91389903
49MAP3K110.90665044
50TAOK10.90440141
51LATS10.88042326
52PKN20.84415032
53RIPK10.82884784
54PRKD20.81404827
55PAK30.79538850
56CHUK0.79076995
57LRRK20.75314834
58PAK20.74879604
59HCK0.74073782
60TYRO30.72602969
61IRAK30.72151175
62CSK0.71232684
63PIM10.70306206
64KSR20.70145631
65BMPR20.69301940
66MARK30.68177175
67EIF2AK20.67939507
68IRAK20.67352250
69NTRK10.66914566
70FER0.66653500
71JAK20.65501614
72IRAK40.64874906
73DAPK30.64066075
74MAPK70.62720589
75FGR0.61451477
76INSR0.59976302
77MAP2K10.57509666
78PIK3CG0.57343675
79ABL10.57065055
80ZAP700.55231431
81LYN0.54006353
82PTK20.53966255
83GRK50.53579766
84MAP3K50.52632456
85GSK3A0.52625504
86MAPK40.51434901
87FGFR40.49732298
88TGFBR20.48812450
89STK40.48479988
90TXK0.48022420
91MAP3K100.47984356
92RPS6KA20.47654828
93ROCK20.47291310
94FLT30.47131714
95STK100.47071508
96HIPK20.46692623
97ROCK10.46531924
98PTK2B0.46208946
99MAP3K10.45574082
100FGFR30.45568183
101LCK0.45433057
102SCYL20.45217049
103CDK60.45210357
104PAK40.45027997
105ADRBK10.44997261
106DYRK30.44688209
107EPHB10.44411470
108FGFR10.44171996
109PKN10.43985585
110PIK3CA0.43518705
111PAK10.42395847
112RPS6KA60.41509317
113PRKCH0.40998782
114PRKCD0.40199134
115CDK150.39726092
116CDK140.38674077
117TEC0.37906269
118EGFR0.37262365
119MELK0.36910254
120RPS6KC10.36859446
121RPS6KL10.36859446
122CDK11A0.35369142
123LIMK10.35011339
124CDK180.34123679
125TGFBR10.33288506
126STK380.32925060
127TAOK20.32732717
128IGF1R0.32641818
129MATK0.32577187
130SRC0.32136500
131MAP3K60.32071958
132SIK30.31411305
133ICK0.31297046
134DYRK1B0.30478095
135MTOR0.30337227
136PTK60.30301622
137IRAK10.30228502
138YES10.29541375
139AKT30.25484327
140BRAF0.25013376

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.57349234
2Graft-versus-host disease_Homo sapiens_hsa053323.24141151
3Leishmaniasis_Homo sapiens_hsa051402.75064266
4Rheumatoid arthritis_Homo sapiens_hsa053232.55212142
5ECM-receptor interaction_Homo sapiens_hsa045122.53072192
6TNF signaling pathway_Homo sapiens_hsa046682.50146043
7Legionellosis_Homo sapiens_hsa051342.49132676
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.25421677
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22191681
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19207459
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11314912
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.99606494
13Pertussis_Homo sapiens_hsa051331.97764608
14Salmonella infection_Homo sapiens_hsa051321.97221895
15Type I diabetes mellitus_Homo sapiens_hsa049401.95545400
16Allograft rejection_Homo sapiens_hsa053301.91540886
17Phagosome_Homo sapiens_hsa041451.91384418
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90872458
19Amoebiasis_Homo sapiens_hsa051461.89885739
20Osteoclast differentiation_Homo sapiens_hsa043801.88745089
21Tuberculosis_Homo sapiens_hsa051521.88093289
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77812299
23Focal adhesion_Homo sapiens_hsa045101.66329069
24African trypanosomiasis_Homo sapiens_hsa051431.55842489
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41143668
26Staphylococcus aureus infection_Homo sapiens_hsa051501.40592368
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37801036
28Protein digestion and absorption_Homo sapiens_hsa049741.37486803
29Asthma_Homo sapiens_hsa053101.36956717
30Measles_Homo sapiens_hsa051621.36940307
31Proteoglycans in cancer_Homo sapiens_hsa052051.36821453
32Shigellosis_Homo sapiens_hsa051311.36478130
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36214757
34Influenza A_Homo sapiens_hsa051641.32279694
35Toxoplasmosis_Homo sapiens_hsa051451.27652553
36Prion diseases_Homo sapiens_hsa050201.23971505
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23576437
38Lysosome_Homo sapiens_hsa041421.18230947
39Hepatitis B_Homo sapiens_hsa051611.17984728
40Apoptosis_Homo sapiens_hsa042101.17130052
41Hematopoietic cell lineage_Homo sapiens_hsa046401.09751930
42Chemokine signaling pathway_Homo sapiens_hsa040621.06843249
43TGF-beta signaling pathway_Homo sapiens_hsa043501.03992112
44Viral myocarditis_Homo sapiens_hsa054161.00961787
45Platelet activation_Homo sapiens_hsa046110.94826088
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.94131408
47MicroRNAs in cancer_Homo sapiens_hsa052060.93233633
48Adherens junction_Homo sapiens_hsa045200.92393784
49Chronic myeloid leukemia_Homo sapiens_hsa052200.92332586
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.90667748
51PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88415535
52Small cell lung cancer_Homo sapiens_hsa052220.87487788
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85035617
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.84525547
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84311049
56Melanoma_Homo sapiens_hsa052180.82572451
57Bladder cancer_Homo sapiens_hsa052190.78481564
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77979749
59HIF-1 signaling pathway_Homo sapiens_hsa040660.76781702
60Herpes simplex infection_Homo sapiens_hsa051680.76009760
61Sulfur metabolism_Homo sapiens_hsa009200.75562478
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73612984
63Caffeine metabolism_Homo sapiens_hsa002320.72493867
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70749990
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.70582792
66Pancreatic cancer_Homo sapiens_hsa052120.67953680
67Complement and coagulation cascades_Homo sapiens_hsa046100.67889913
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65547286
69Sphingolipid metabolism_Homo sapiens_hsa006000.65303021
70HTLV-I infection_Homo sapiens_hsa051660.64930358
71B cell receptor signaling pathway_Homo sapiens_hsa046620.63123685
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62052820
73Autoimmune thyroid disease_Homo sapiens_hsa053200.61104176
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59618164
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58223825
76Hepatitis C_Homo sapiens_hsa051600.57965688
77p53 signaling pathway_Homo sapiens_hsa041150.57617261
78Renin-angiotensin system_Homo sapiens_hsa046140.56810247
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.56734060
80Acute myeloid leukemia_Homo sapiens_hsa052210.54487186
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.54474758
82Prolactin signaling pathway_Homo sapiens_hsa049170.52377230
83Antigen processing and presentation_Homo sapiens_hsa046120.51457080
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.50390728
85Dilated cardiomyopathy_Homo sapiens_hsa054140.49275325
86MAPK signaling pathway_Homo sapiens_hsa040100.49204295
87Galactose metabolism_Homo sapiens_hsa000520.49104500
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49060253
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49039486
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48897594
91Mineral absorption_Homo sapiens_hsa049780.47630923
92Vibrio cholerae infection_Homo sapiens_hsa051100.47058447
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.46872725
94Prostate cancer_Homo sapiens_hsa052150.46313223
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45786651
96Viral carcinogenesis_Homo sapiens_hsa052030.45645771
97Other glycan degradation_Homo sapiens_hsa005110.42564888
98Rap1 signaling pathway_Homo sapiens_hsa040150.42158151
99Endocytosis_Homo sapiens_hsa041440.41749755
100Glioma_Homo sapiens_hsa052140.41452107
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38748267
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.38589815
103Notch signaling pathway_Homo sapiens_hsa043300.38527512
104Insulin resistance_Homo sapiens_hsa049310.36744702
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36427999
106Pathways in cancer_Homo sapiens_hsa052000.34989873
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34254232
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33698803
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33482701
110Hippo signaling pathway_Homo sapiens_hsa043900.33389829
111Type II diabetes mellitus_Homo sapiens_hsa049300.33350526
112FoxO signaling pathway_Homo sapiens_hsa040680.33343888
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32158018
114VEGF signaling pathway_Homo sapiens_hsa043700.31582313
115Renal cell carcinoma_Homo sapiens_hsa052110.31173037

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